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Kenichi Mishima

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Nobuaki Egashira; Moe Abe; Katsunori Iwasaki; Kenichi Mishima; Tomiko Niki; Ryozo Oishi; Atsunori Shirakawa; Michihiro Fujiwara
Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system.
Masayuki Fujioka; Michihiro Fujiwara; Kazuhide Hayakawa; Keiichi Irie; Katsunori Iwasaki; Koichi Kokame; Kenichi Mishima; Toshiyuki Miyata; Carl Muroi; Takafumi Nakano; Kenji Nishio; Kazuo Okuchi; Yuya Sakamoto; Yoshiharu Akitake; Fumiaki Banno; Yasuhiro Yonekawa; Bo K Siesjö
ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury.
Carl Muroi; Martin Seule; Kenichi Mishima; Emanuela Keller
Novel treatments for vasospasm after subarachnoid hemorrhage.

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2013: Nobuaki Egashira; Moe Abe; Katsunori Iwasaki; Kenichi Mishima; Tomiko Niki; Ryozo Oishi; Atsunori Shirakawa; Michihiro Fujiwara
Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system.
Psychopharmacology 2013;226(2):295-305.
2012: Masayuki Fujioka; Michihiro Fujiwara; Kazuhide Hayakawa; Keiichi Irie; Katsunori Iwasaki; Koichi Kokame; Kenichi Mishima; Toshiyuki Miyata; Carl Muroi; Takafumi Nakano; Kenji Nishio; Kazuo Okuchi; Yuya Sakamoto; Yoshiharu Akitake; Fumiaki Banno; Yasuhiro Yonekawa; Bo K Siesjö
ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2012;33(5):1107-15.
2012: Carl Muroi; Martin Seule; Kenichi Mishima; Emanuela Keller
Novel treatments for vasospasm after subarachnoid hemorrhage.
Current opinion in critical care 2012;18(2):119-26.
2012: Nobuaki Egashira; Katsunori Iwasaki; Naomi Manome; Kenichi Mishima; Ryozo Oishi; Michihiro Fujiwara
Involvement of opioid system in cognitive deficits induced by ∆⁹-tetrahydrocannabinol in rats.
Psychopharmacology 2012;219(4):1111-8.
2012: Taro Shindo; Kotaro Takasaki; Kanako Uchida; Naoki Uchida; Shutaro Katsurabayashi; Kaori Kubota; Kenichi Mishima; Ryoji Nishimura; Rika Onimura; Michihiro Fujiwara; Keiichi Irie; Katsunori Iwasaki
Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors.
Biological & pharmaceutical bulletin 2012;35(12):2141-7.
2012: Hiroyuki Kawano; Masafumi Kubo; Natsuko Kubo; Kaori Kubota; Kenichi Mishima; Hideto Okuda; Kotaro Takasaki; Yuta Yamashita; Michihiro Fujiwara; N Charles Harata; Yasuhiro Kakazu; Shutaro Katsurabayashi; Katsunori Iwasaki
Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.
PloS one 2012;7(10):e48034.
2012: Sei Higuchi; Keiichi Irie; Katsunori Iwasaki; Mai Katsuki; Kiyoshi Matsuyama; Kenji Mishima; Kenichi Mishima; Shohei Mishima; Makiko Ohji; Ryuji Yamaguchi; Yoshiharu Akitake; Maiko Araki; Kazuhide Hayakawa; Michihiro Fujiwara
Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.
PloS one 2012;7(6):e38609.
2012: Yuki Fukumitsu; Keiichi Irie; Nobuhiro Kashige; Abu Hassan Ahmad; Hitoshi Aonuma; Hamady Dieng; Kenichi Mishima; Yukihiko Nakashima; Tomomitsu Satho; Fumio Miake
Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus.
Parasites & vectors 2012;5():92.
2012: Nobuaki Egashira; Moe Abe; Katsunori Iwasaki; Kenichi Mishima; Tomiko Niki; Ryozo Oishi; Atsunori Shirakawa; Michihiro Fujiwara
N-acetyl-L-cysteine inhibits marble-burying behavior in mice.
Journal of pharmacological sciences 2012;119(1):97-101.
2012: Nobuaki Egashira; Katsunori Iwasaki; Kenichi Mishima; Masaki Nagao; Ryozo Oishi; Ryoko Okuno; Atsunori Shirakawa; Michihiro Fujiwara
Role of 5-hydroxytryptamine2C receptors in marble-burying behavior in mice.
Biological & pharmaceutical bulletin 2012;35(3):376-9.
2011: Nobuaki Egashira; Atsunori Shirakawa; Ryoko Okuno; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara
Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice.
Pharmacology, biochemistry, and behavior 2011;99(1):52-8.
2011: Ai Nogami; Yuri Sakata; Naoki Uchida; Kazuko Yamaguchi; Chihiro Kawasaki; Taro Shindo; Kaori Kubota; Shutaro Katsurabayashi; Kotaro Takasaki; Kenichi Mishima; Ryoji Nishimura; Michihiro Fujiwara; Katsunori Iwasaki
Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia.
Journal of natural medicines 2011;65(2):275-81.
2011: Nobuaki Egashira; Ayumi Ishibashi; Katsunori Iwasaki; Kenichi Mishima; Ryoji Nishimura; Ai Nogami; Ryozo Oishi; Kotaro Takasaki; Naoki Uchida; Michihiro Fujiwara
Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: possible involvement of GABA(A)-benzodiazepine receptor complex.
Journal of pharmacological sciences 2011;116(3):316-20.
2011: Kotaro Takasaki; Kanako Uchida; Kazuko Yamaguchi; Risako Fujikawa; Michihiro Fujiwara; Shutaro Katsurabayashi; Chihiro Kawasaki; Kaori Kubota; Kenichi Mishima; Koji Morishita; Masahiko Morita; Kazuya Nakamura; Ai Nogami; Katsunori Iwasaki
Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia.
Journal of pharmacological sciences 2011;116(2):232-7.
2011: Sei Higuchi; Makiko Ohji; Maiko Araki; Riyo Furuta; Mai Katsuki; Ryuji Yamaguchi; Yoshiharu Akitake; Kiyoshi Matsuyama; Keiichi Irie; Kenichi Mishima; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.
Behavioural brain research 2011;216(1):477-80.
2010: Masahiro Tsuji; Naoya Aoo; Kazuhiro Harada; Yuya Sakamoto; Yoshiharu Akitake; Keiichi Irie; Kenichi Mishima; Tomoaki Ikeda; Michihiro Fujiwara
Sex differences in the benefits of rehabilitative training during adolescence following neonatal hypoxia-ischemia in rats.
Experimental neurology 2010;226(2):285-92.
2010: Shin Ishikane; Kenichi Yamahara; Masaharu Sada; Kazuhiko Harada; Makoto Kodama; Hatsue Ishibashi-Ueda; Kazuhide Hayakawa; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara; Kenji Kangawa; Tomoaki Ikeda
Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats.
Journal of molecular and cellular cardiology 2010;49(5):753-61.
2010: Tamami Haraguchi; Katsunori Iwasaki; Kotaro Takasaki; Kanako Uchida; Tetsuya Naito; Ai Nogami; Kaori Kubota; Taro Shindo; Naoki Uchida; Shutaro Katsurabayashi; Kenichi Mishima; Ryoji Nishimura; Michihiro Fujiwara
Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia.
Brain research 2010;1353():125-32.
2010: Takuya Watanabe; Katsunori Iwasaki; Kotaro Takasaki; Norito Yamagata; Mutsumi Fujino; Ai Nogami; Miyuki Ii; Shutaro Katsurabayashi; Kenichi Mishima; Michihiro Fujiwara
Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Journal of neuroscience research 2010;88(9):1908-17.
2010: Nobuaki Egashira; Emi Koushi; Ryoko Okuno; Atsunori Shirakawa; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara
Depression-like behavior and reduced plasma testosterone levels in the senescence-accelerated mouse.
Behavioural brain research 2010;209(1):142-7.
2010: Fengling Pu; Tomohiro Kaneko; Makiko Enoki; Keiichi Irie; Takuya Okamoto; Yasuo Sei; Nobuaki Egashira; Ryozo Oishi; Kenichi Mishima; Hidetoshi Kamimura; Katsunori Iwasaki; Michihiro Fujiwara
Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia.
Journal of natural medicines 2010;64(2):167-74.
2010: Sei Higuchi; Keiichi Irie; Takafumi Nakano; Yuya Sakamoto; Yoshiharu Akitake; Maiko Araki; Makiko Ohji; Riyo Furuta; Mai Katsuki; Ryuji Yamaguchi; Kiyoshi Matsuyama; Kenichi Mishima; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Reducing acyl migration during purification of 2-arachidonoylglycerol from biological samples before gas chromatography mass spectrometry analysis.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2010;26(11):1199-202.
2010: Sei Higuchi; Keiichi Irie; Shohei Mishima; Maiko Araki; Makiko Ohji; Atsunori Shirakawa; Yoshiharu Akitake; Kiyoshi Matsuyama; Kenichi Mishima; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
The cannabinoid 1-receptor silent antagonist O-2050 attenuates preference for high-fat diet and activated astrocytes in mice.
Journal of pharmacological sciences 2010;112(3):369-72.
2009: Kazunori Sano; Emi Koushi; Keiichi Irie; Sei Higuchi; Ryota Tsuchihashi; Junei Kinjo; Nobuaki Egashira; Ryozo Oishi; Naoki Uchida; Hiroshi Nagai; Ryoji Nishimura; Hiroyuki Tanaka; Satoshi Morimoto; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress.
Biological & pharmaceutical bulletin 2009;32(12):2065-7.
2009: Tamami Haraguchi; Kotaro Takasaki; Tetsuya Naito; Kazuhide Hayakawa; Shutaro Katsurabayashi; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism.
Neuroscience letters 2009;464(3):151-5.
2009: Kazuhide Hayakawa; Keiichi Irie; Kazunori Sano; Takuya Watanabe; Sei Higuchi; Makiko Enoki; Takafumi Nakano; Kazuhiko Harada; Shin Ishikane; Tomoaki Ikeda; Masayuki Fujioka; Kensuke Orito; Katsunori Iwasaki; Kenichi Mishima; Michihiro Fujiwara
Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism.
Biological & pharmaceutical bulletin 2009;32(9):1538-44.
2009: Fengling Pu; Kyoko Motohashi; Tomohiro Kaneko; Yurika Tanaka; Naomi Manome; Keiichi Irie; Jiro Takata; Nobuaki Egashira; Ryozo Oishi; Takuya Okamoto; Yasuo Sei; Takako Yokozawa; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats.
Journal of pharmacological sciences 2009;109(3):424-30.
2009: Naoki Uchida; Nobuaki Egashira; Katsunori Iwasaki; Ayumi Ishibashi; Ryosuke Tashiro; Ai Nogami; Naomi Manome; Moe Abe; Kotaro Takasaki; Kenichi Mishima; Jiro Takata; Ryozo Oishi; Ryoji Nishimura; Michihiro Fujiwara
Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents.
Biological & pharmaceutical bulletin 2009;32(3):372-5.
2009: Takuya Watanabe; Norito Yamagata; Kotaro Takasaki; Kazunori Sano; Kazuhide Hayakawa; Shutaro Katsurabayashi; Nobuaki Egashira; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease.
Brain research 2009;1249():222-8.
2009: Nobuaki Egashira; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara
New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in psychological and cognitive functions.
Journal of pharmacological sciences 2009;109(1):44-9.
2008: Kazuhide Hayakawa; Kenichi Mishima; Keiichi Irie; Mai Hazekawa; Shohei Mishima; Masayuki Fujioka; Kensuke Orito; Nobuaki Egashira; Shutaro Katsurabayashi; Kotaro Takasaki; Katsunori Iwasaki; Michihiro Fujiwara
Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism.
Neuropharmacology 2008;55(8):1280-6.
2008: Nobuaki Egashira; Ryoko Okuno; Michihiko Matsushita; Moe Abe; Kenichi Mishima; Katsunori Iwasaki; Ryoji Nishimura; Ryozo Oishi; Michihiro Fujiwara
Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms.
European journal of pharmacology 2008;592(1-3):103-8.
2008: Nobuaki Egashira; Ryoko Okuno; Moe Abe; Michihiko Matsushita; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Ryoji Nishimura; Yoshiaki Matsumoto; Michihiro Fujiwara
Calcium-channel antagonists inhibit marble-burying behavior in mice.
Journal of pharmacological sciences 2008;108(1):140-3.
2008: Nobuaki Egashira; Katsunori Iwasaki; Ayumi Ishibashi; Kazuhide Hayakawa; Ryoko Okuno; Moe Abe; Naoki Uchida; Kenichi Mishima; Kotaro Takasaki; Ryoji Nishimura; Ryozo Oishi; Michihiro Fujiwara
Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex.
Progress in neuro-psychopharmacology & biological psychiatry 2008;32(6):1516-20.
2008: Nobuaki Egashira; Tomomi Matsuda; Emi Koushi; Fuminori Higashihara; Kenichi Mishima; Shozo Chidori; Nobuyoshi Hasebe; Katsunori Iwasaki; Ryoji Nishimura; Ryozo Oishi; Michihiro Fujiwara
Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system.
European journal of pharmacology 2008;589(1-3):117-21.
2008: Nobuaki Egashira; Ryoko Okuno; Satoko Harada; Michihiko Matsushita; Kenichi Mishima; Katsunori Iwasaki; Ryoji Nishimura; Ryozo Oishi; Michihiro Fujiwara
Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder.
European journal of pharmacology 2008;586(1-3):164-70.
2008: Kazuhide Hayakawa; Kenichi Mishima; Masanori Nozako; Mai Hazekawa; Shohei Mishima; Masayuki Fujioka; Kensuke Orito; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism.
Stroke; a journal of cerebral circulation 2008;39(3):951-8.
2008: Nobuaki Egashira; Noriko Ishigami; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara
Delta9-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats.
Progress in neuro-psychopharmacology & biological psychiatry 2008;32(2):499-506.
2008: Kazunori Sano; Kenichi Mishima; Emi Koushi; Kensuke Orito; Nobuaki Egashira; Keiichi Irie; K Takasaki; Shutaro Katsurabayashi; Katsunori Iwasaki; N Uchida; Takashi Egawa; Y Kitamura; Ryoji Nishimura; Michihiro Fujiwara
Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons.
Neuroscience 2008;151(2):320-8.
2008: Kazuhide Hayakawa; Kenichi Mishima; Mai Hazekawa; Kazunori Sano; Keiichi Irie; Kensuke Orito; Takashi Egawa; Yoshihisa Kitamura; Naoki Uchida; Ryoji Nishimura; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism.
Brain research 2008;1188():157-64.
2008: Takuya Watanabe; Katsunori Iwasaki; Shin Ishikane; Tetsuya Naitou; Yoshitaka Yoshimitsu; Norito Yamagata; Mehmeto Bülent Ozdemir; Kotaro Takasaki; Nobuaki Egashira; Kenichi Mishima; Michihiro Fujiwara
Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats.
Journal of pharmacological sciences 2008;106(1):84-91.
2008: Nobuaki Egashira; Noriko Ishigami; Fengling Pu; Kenichi Mishima; Katsunori Iwasaki; Kensuke Orito; Ryozo Oishi; Michihiro Fujiwara
Theanine prevents memory impairment induced by repeated cerebral ischemia in rats.
Phytotherapy research : PTR 2008;22(1):65-8.
2008: Nobuaki Egashira; Kouji Kurauchi; Katsunori Iwasaki; Kenichi Mishima; Kensuke Orito; Ryozo Oishi; Michihiro Fujiwara
Schizandrin reverses memory impairment in rats.
Phytotherapy research : PTR 2008;22(1):49-52.
2007: Nobuaki Egashira; Emi Koushi; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara
2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.
Journal of pharmacological sciences 2007;105(4):361-6.
2007: Nobuaki Egashira; Kazuhide Hayakawa; Megumi Osajima; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara
Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice.
Journal of pharmacological sciences 2007;105(2):211-4.
2007: Kazuhide Hayakawa; Kenichi Mishima; Masanori Nozako; Mai Hazekawa; Keiichi Irie; Masayuki Fujioka; Kensuke Orito; Kohji Abe; Nobuyoshi Hasebe; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism.
Journal of neurochemistry 2007;102(5):1488-96.
2007: Fengling Pu; Kenichi Mishima; Keiichi Irie; Kyouko Motohashi; Yurika Tanaka; Kensuke Orito; Takashi Egawa; Yoshihisa Kitamura; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats.
Journal of pharmacological sciences 2007;104(4):329-34.
2007: Nobuaki Egashira; Satoko Harada; Ryoko Okuno; Michihiko Matsushita; Ryoji Nishimura; Kenichi Mishima; Katsunori Iwasaki; Kensuke Orito; Michihiro Fujiwara
Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine.
European journal of pharmacology 2007;563(1-3):149-54.
2007: Katsunori Iwasaki; Nobuaki Egashira; Yuki Takagaki; Yoshitaka Yoshimitsu; izzettin hatip-al-khatib; Kenichi Mishima; Michihiro Fujiwara
Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats.
Biological & pharmaceutical bulletin 2007;30(4):698-701.
2007: Kazuhide Hayakawa; Kenichi Mishima; Masanori Nozako; Mai Hazekawa; Ayumi Ogata; Masayuki Fujioka; Kazuhiko Harada; Shohei Mishima; Kensuke Orito; Nobuaki Egashira; Katunori Iwasaki; Michihiro Fujiwara
Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.
Life sciences 2007;80(16):1466-71.
2007: Nobuaki Egashira; Akito Tanoue; Tomomi Matsuda; Emi Koushi; Satoko Harada; Yukio Takano; Gozoh Tsujimoto; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice.
Behavioural brain research 2007;178(1):123-7.
2007: Kazuhide Hayakawa; Kenichi Mishima; Masanori Nozako; Mai Hazekawa; Yo Aoyama; Ayumi Ogata; Kazuhiko Harada; Masayuki Fujioka; Kohji Abe; Nobuaki Egashira; Katunori Iwasaki; Michihiro Fujiwara
High-cholesterol feeding aggravates cerebral infarction via decreasing the CB1 receptor.
Neuroscience letters 2007;414(2):183-7.
2007: Kazuhide Hayakawa; Kenichi Mishima; Masanori Nozako; Ayumi Ogata; Mai Hazekawa; An-Xin Liu; Masayuki Fujioka; Kohji Abe; Nobuyoshi Hasebe; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance.
Neuropharmacology 2007;52(4):1079-87.
2007: izzettin hatip-al-khatib; Funda Bölukbaşi Hatip; Yoshitaka Yoshimitsu; Katsunori Iwasaki; Nobuaki Egashira; An-Xin Liu; Kenichi Mishima; Michihiro Fujiwara
Effect of Toki-shakuyaku-san on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats.
Phytotherapy research : PTR 2007;21(3):291-4.
2007: Nobuaki Egashira; Naomi Manome; Kouji Kurauchi; Yoshiaki Matsumoto; Katsunori Iwasaki; Kenichi Mishima; Yukihiro Shoyama; Michihiro Fujiwara
Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats.
Phytotherapy research : PTR 2007;21(2):126-9.
2007: izzettin hatip-al-khatib; Katsunori Iwasaki; Nobuaki Egashira; Daisuke Ishibashi; Kenichi Mishima; Michihiro Fujiwara
Comparison of single- and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion.
Journal of pharmacological sciences 2007;103(1):83-91.
2006: Kenta Umeda; Katsuya Suemaru; Nobuko Todo; Nobuaki Egashira; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara; Hiroaki Araki
Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice.
European journal of pharmacology 2006;553(1-3):157-62.
2006: Nobuaki Egashira; Tomomi Matsuda; Emi Koushi; Kenichi Mishima; Katsunori Iwasaki; Yukihiro Shoyama; Michihiro Fujiwara
Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.
European journal of pharmacology 2006;550(1-3):117-22.
2006: Katsunori Iwasaki; Nobuaki Egashira; izzettin hatip-al-khatib; Yuki Akiyoshi; Takashi Arai; Yuki Takagaki; Takuya Watanabe; Kenichi Mishima; Michihiro Fujiwara
Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats.
Brain research 2006;1097(1):216-23.
2006: Hiroshi Nagai; Nobuaki Egashira; Kazunori Sano; Ayumi Ogata; Ai Mizuki; Kenichi Mishima; Katsunori Iwasaki; Yukihiro Shoyama; Ryoji Nishimura; Michihiro Fujiwara
Antipsychotics improve Delta9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice.
Pharmacology, biochemistry, and behavior 2006;84(2):330-6.
2006: Nobuaki Egashira; Jian-Chen Li; Ai Mizuki; Keita Yamauchi; Tomoko Matsuda; Megumi Osajima; Michihiko Matsushita; Kenichi Mishima; Katsunori Iwasaki; Shuji Hara; Nobuhumi Ono; Ryoji Nishimura; Toshihiro Nohara; Michihiro Fujiwara
Antagonistic effects of methanolic extract of Polygala telephioides on morphine responses in mice.
Journal of ethnopharmacology 2006;104(1-2):193-8.
2006: Nobuaki Egashira; Akiko Yano; Noriko Ishigami; Kenichi Mishima; Katsunori Iwasaki; Masayuki Fujioka; Michihiko Matsushita; Ryoji Nishimura; Michihiro Fujiwara
Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats.
Brain research 2006;1069(1):54-62.
2006: Nobuaki Egashira; Yoshiaki Matsumoto; Kenichi Mishima; Katsunori Iwasaki; Masayuki Fujioka; Michihiko Matsushita; Yukihiro Shoyama; Ryoji Nishimura; Michihiro Fujiwara
Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization.
Pharmacology, biochemistry, and behavior 2006;83(1):161-7.
2006: Tomoaki Ikeda; Kenichi Mishima; Naoya Aoo; Kazuhiko Harada; An Xin Liu; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara; Tsuyomu Ikenoue
Rehabilitative training tasks improve spatial learning impairment in the water maze following hypoxic-ischemic insult in neonatal rats.
Pediatric research 2006;59(1):61-5.
2005: Jesmin I Noor; Tomoaki Ikeda; Kenichi Mishima; Naoya Aoo; Sumie Ohta; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara; Tsuyomu Ikenoue
Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy.
Stroke; a journal of cerebral circulation 2005;36(11):2468-74.
2005: Nobuaki Egashira; Akito Tanoue; Fuminori Higashihara; Hiroko Fuchigami; Kazunori Sano; Kenichi Mishima; Yoshihiko Fukue; Hiroshi Nagai; Yukio Takano; Gozoh Tsujimoto; Jeanne Stemmelin; Guy Griebel; Katsunori Iwasaki; Tomoaki Ikeda; Ryoji Nishimura; Michihiro Fujiwara
Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(11):1996-2005.
2005: Nobuaki Egashira; Katsunori Iwasaki; Akihiko Takashima; Takuya Watanabe; Hideyuki Kawabe; Tomomi Matsuda; Kenichi Mishima; Shozo Chidori; Ryoji Nishimura; Michihiro Fujiwara
Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice.
Brain research 2005;1059(1):7-12.
2005: Michihiko Matsushita; Nobuaki Egashira; Satoko Harada; Ryoko Okuno; Kenichi Mishima; Katsunori Iwasaki; Ryoji Nishimura; Michihiro Fujiwara
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.
Journal of pharmacological sciences 2005;99(2):154-9.
2005: izzettin hatip-al-khatib; Katsunori Iwasaki; Yoshitaka Yoshimitsu; Takashi Arai; Nobuaki Egashira; Kenichi Mishima; Tomoaki Ikeda; Michihiro Fujiwara
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
British journal of pharmacology 2005;145(8):1035-44.
2005: Nobuaki Egashira; Katsunori Iwasaki; Yuki Akiyoshi; Yuki Takagaki; izzettin hatip-al-khatib; Kenichi Mishima; Kouji Kurauchi; Tomoaki Ikeda; Michihiro Fujiwara
Protective effect of Toki-shakuyaku-san on amyloid beta25-35-induced neuronal damage in cultured rat cortical neurons.
Phytotherapy research : PTR 2005;19(5):450-3.
2005: Kenichi Mishima; Kazuhide Hayakawa; Kohji Abe; Tomoaki Ikeda; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism.
Stroke; a journal of cerebral circulation 2005;36(5):1077-82.
2005: Shinji Katsuragi; Tomoaki Ikeda; Isao Date; Tetsuro Shingo; Takao Yasuhara; Kenichi Mishima; Naoya Aoo; Kazuhiko Harada; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara; Tsuyomu Ikenoue
Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats.
American journal of obstetrics and gynecology 2005;192(4):1028-37.
2005: Kenichi Mishima; Tomoaki Ikeda; Naoya Aoo; Nobuhiko Takai; Sentaro Takahashi; Nobuaki Egashira; Tsuyomu Ikenoue; Katsunori Iwasaki; Michihiro Fujiwara
Hypoxia-ischemic insult in neonatal rats induced slowly progressive brain damage related to memory impairment.
Neuroscience letters 2005;376(3):194-9.
2005: Tomoaki Ikeda; Kenichi Mishima; Naoya Aoo; An Xin Liu; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara; Tsuyomu Ikenoue
Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide and hypoxia-ischemia in neonatal rats.
American journal of obstetrics and gynecology 2005;192(3):719-26.
2005: Fengling Pu; Kenichi Mishima; Nobuaki Egashira; Yuki Akiyoshi; An-Xin Liu; Kazunori Sano; Keiichi Irie; Daisuke Ishibashi; izzettin hatip-al-khatib; Katsunori Iwasaki; Kouji Kurauchi; Katsunori Iwasaki; Michihiro Fujiwara
Post-ischemic treatment with toki-shakuyaku-san (tang-gui-shao-yao-san) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats.
The American journal of Chinese medicine 2005;33(3):475-89.
2004: Tomoaki Ikeda; Kenichi Mishima; Naoya Aoo; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara; Tsuyomu Ikenoue
Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage.
American journal of obstetrics and gynecology 2004;191(6):2132-41.
2004: Kazuhide Hayakawa; Kenichi Mishima; Kohji Abe; Nobuyoshi Hasebe; Fumie Takamatsu; Hiromi Yasuda; Tomoaki Ikeda; Keiichiro Inui; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.
Neuroreport 2004;15(15):2381-5.
2004: izzettin hatip-al-khatib; Katsunori Iwasaki; Eun-hee Chung; Nobuaki Egashira; Kenichi Mishima; Michihiro Fujiwara
Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.
Life sciences 2004;75(16):1967-78.
2004: izzettin hatip-al-khatib; Nobuaki Egashira; Kenichi Mishima; Katsunori Iwasaki; Kiyo Iwasaki; Kouji Kurauchi; Keiichiro Inui; Tomoaki Ikeda; Michihiro Fujiwara
Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test.
Journal of pharmacological sciences 2004;96(1):33-41.
2004: Kenichi Mishima; Akito Tanoue; Masakazu Tsuda; Nobuyoshi Hasebe; Yoshihiko Fukue; Nobuaki Egashira; Yukio Takano; Hiro-O Kamiya; Gozoh Tsujimoto; Katsunori Iwasaki; Michihiro Fujiwara
Characteristics of behavioral abnormalities in alpha1d-adrenoceptors deficient mice.
Behavioural brain research 2004;152(2):365-73.
2004: Nobuaki Egashira; Kazuhide Hayakawa; Kenichi Mishima; Hitomi Kimura; Katsunori Iwasaki; Michihiro Fujiwara
Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice.
Neuroscience letters 2004;363(1):58-61.
2004: Kenichi Mishima; Tomoaki Ikeda; Tetsuya Yoshikawa; Naoya Aoo; Nobuaki Egashira; Yi X Xia; Tsuyomu Ikenoue; Katsunori Iwasaki; Michihiro Fujiwara
Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats.
Behavioural brain research 2004;151(1-2):209-17.
2004: Fengling Pu; Kenichi Mishima; Nobuaki Egashira; Katsunori Iwasaki; Tomohiro Kaneko; Tomoko Uchida; Keiichi Irie; Daisuke Ishibashi; Hajime Fujii; Kenichi Kosuna; Michihiro Fujiwara
Protective effect of buckwheat polyphenols against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia.
Journal of pharmacological sciences 2004;94(4):393-402.
2004: Nobuaki Egashira; Akito Tanoue; Fuminori Higashihara; Kenichi Mishima; Yoshihiko Fukue; Yukio Takano; Gozoh Tsujimoto; Katsunori Iwasaki; Michihiro Fujiwara
V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze.
Neuroscience letters 2004;356(3):195-8.
2004: Nobuaki Egashira; Kenichi Mishima; Tomoko Uchida; Nobuyoshi Hasebe; Hiroshi Nagai; Ai Mizuki; Katsunori Iwasaki; Hisanori Ishii; Ryoji Nishimura; Yukihiro Shoyama; Michihiro Fujiwara
Anandamide inhibits the DOI-induced head-twitch response in mice.
Psychopharmacology 2004;171(4):382-9.
2004: Katsunori Iwasaki; Eun-hee Chung; Nobuaki Egashira; izzettin hatip-al-khatib; Kenichi Mishima; Takashi Egawa; Keiichi Irie; Michihiro Fujiwara
Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats.
Brain research 2004;995(1):131-9.
2004: Katsunori Iwasaki; izzettin hatip-al-khatib; Nobuaki Egashira; Yuki Akiyoshi; Takashi Arai; Kenichi Mishima; Yuki Takagaki; Keiichiro Inui; Michihiro Fujiwara
Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats.
Neurotoxicity research 2004;6(4):299-309.
2004: Keiichrio Inui; Nobuaki Egashira; Kenichi Mishima; Akiko Yano; Yoshiaki Matsumoto; Nobuyoshi Hasebe; Kohji Abe; Kazuhide Hayakawa; Tomoaki Ikeda; Katsunori Iwasaki; Michihiro Fujiwara
The serotonin1A receptor agonist 8-OHDPAT reverses delta 9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats.
Neurotoxicity research 2004;6(2):153-8.
2003: Katsunori Iwasaki; Kenichi Mishima; Nobuaki Egashira; Izzettin Hatip Al-Khatib; Daisuke Ishibashi; Keiichi Irie; Hirotoshi Kobayashi; Takashi Egawa; Michihiro Fujiwara
Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats.
Journal of pharmacological sciences 2003;93(2):188-96.
2003: Hidenobu Ochiai; Tomoaki Ikeda; Kenichi Mishima; Naoya Aoo; Katsunori Iwasaki; Michihiro Fujiwara; Shinichi Nakano; Tsuyomu Ikenoue; Shinichiro Wakisaka
Local administration of glial cell line-derived neurotrophic factor improves behavioral and histological deficit of neonatal Erb's palsy in rats.
Neurosurgery 2003;53(4):973-7; discussion 977-8.
2003: Kenichi Mishima; H Tsukikawa; I Miura; K Inada; Kohji Abe; Yoshiaki Matsumoto; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.
Neuropharmacology 2003;44(4):541-52.
2003: Kenichi Mishima; Fengling Pu; T Kaneko; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Post-ischemic administration [correction of administeration] but not pre-ischemic administration [correction of administeration] of NG-nitro-L-arginine prevents spatial memory impairments and apoptosis by an inhibition of a delayed increase in NOx- in the hippocampus following repeated cerebral ischemia.
Neuropharmacology 2003;44(4):533-40.
2003: Kiwamu Yamagishi; Kenichi Mishima; Yusuke Ohgami; Katsunori Iwasaki; Masayuki Jimbo; Hiroyuki Masuda; Yasuyuki Igarashi; Jin-ichi Inokuchi; Michihiro Fujiwara
A synthetic ceramide analog ameliorates spatial cognition deficit and stimulates biosynthesis of brain gangliosides in rats with cerebral ischemia.
European journal of pharmacology 2003;462(1-3):53-60.
2003: Kenichi Mishima; Takamitsu Tanaka; Fengling Pu; Nobuaki Egashira; Katsunori Iwasaki; Ryoji Hidaka; Kazuhisa Matsunaga; Jiro Takata; Yoshiharu Karube; Michihiro Fujiwara
Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice.
Neuroscience letters 2003;337(1):56-60.
2002: Keiichi Irie; Kenichi Mishima; Daisuke Ishibashi; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia.
Life sciences 2002;72(4-5):621-9.
2002: Eun hee Chung; Katsunori Iwasaki; Kenichi Mishima; Nobuaki Egashira; Michihiro Fujiwara
Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat.
Life sciences 2002;72(4-5):609-19.
2002: Kenichi Mishima; Nobuaki Egashira; Yoshiaki Matsumoto; Katsunori Iwasaki; Michihiro Fujiwara
Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze.
Life sciences 2002;72(4-5):397-407.
2002: Nobuaki Egashira; Katsunori Iwasaki; Motoki Ishibashi; izzettin hatip-al-khatib; Benjamin Wolozin; Kenichi Mishima; Keiichi Irie; Michihiro Fujiwara
Hypoxia enhances beta-amyloid-induced apoptosis in rat cultured hippocampal neurons.
Japanese journal of pharmacology 2002;90(4):321-7.
2002: Kenichi Mishima; Megumi Fujii; Naoya Aoo; Tetsuya Yoshikawa; Yoshihiko Fukue; Yoko Honda; Nobuaki Egashira; Katsunori Iwasaki; Yukihiro Shoyama; Michihiro Fujiwara
The pharmacological characterization of attentional processes using a two-lever choice reaction time task in rats.
Biological & pharmaceutical bulletin 2002;25(12):1570-6.
2002: Nobuaki Egashira; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Intracerebral microinjections of delta 9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats.
Brain research 2002;952(2):239-45.
2002: Tomoaki Ikeda; Kenichi Mishima; Tetsuya Yoshikawa; Katsunori Iwasaki; Michihiro Fujiwara; Yi X Xia; Tsuyomu Ikenoue
Dexamethasone prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats.
Behavioural brain research 2002;136(1):161-70.
2002: Hidenobu Ochiai; Tomoaki Ikeda; Kenichi Mishima; Tetsuya Yoshikawa; Naoya Aoo; Katsunori Iwasaki; Michihiro Fujiwara; Tsuyomu Ikenoue; Shinichi Nakano; Shinichiro Wakisaka
Development of a novel experimental rat model for neonatal pre-ganglionic upper brachial plexus injury.
Journal of neuroscience methods 2002;119(1):51-7.
2002: Nobuaki Egashira; Kenichi Mishima; Shutaro Katsurabayashi; Tomohiro Yoshitake; Yoshiaki Matsumoto; Junichi Ishida; Masatoshi Yamaguchi; Katsunori Iwasaki; Michihiro Fujiwara
Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.
European journal of pharmacology 2002;445(3):221-9.
2002: Takashi Egawa; Kenichi Mishima; Nobuaki Egashira; Misa Fukuzawa; Kohji Abe; Tetsuji Yae; Katsunori Iwasaki; Michihiro Fujiwara
Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the hippocampal cholinergic and noradrenergic contents.
Behavioural brain research 2002;129(1-2):31-9.
2001: Kenichi Mishima; Nobuaki Egashira; N Hirosawa; M Fujii; Yoshiaki Matsumoto; Katsunori Iwasaki; Michihiro Fujiwara
Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats.
Japanese journal of pharmacology 2001;87(4):297-308.
2001: I Hatip-Al-khati; F Bölükbasi; Kenichi Mishima; Nobuaki Egashira; Katsunori Iwasaki; Michihiro Fujiwara
Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study.
Japanese journal of pharmacology 2001;87(4):277-87.
2001: Kenichi Mishima; H Tsukikawa; K Inada; M Fujii; Katsunori Iwasaki; Yoshiaki Matsumoto; Kohji Abe; Takashi Egawa; Michihiro Fujiwara
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
European journal of pharmacology 2001;427(1):43-52.
2001: izzettin hatip-al-khatib; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.
Brain research 2001;902(1):108-18.
2001: Tomoaki Ikeda; Kenichi Mishima; T Yoshikawa; Katsunori Iwasaki; Michihiro Fujiwara; Yi X Xia; Tsuyomu Ikenoue
Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats.
Behavioural brain research 2001;118(1):17-25.
2000: Kenichi Mishima; Katsunori Iwasaki; H Tsukikawa; Yoshiaki Matsumoto; Nobuaki Egashira; Kohji Abe; Takashi Egawa; Michihiro Fujiwara
The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.
Japanese journal of pharmacology 2000;84(2):163-73.
1997: Takashi Egawa; Kenichi Mishima; Yoshiaki Matsumoto; Katsunori Iwasaki; K Iwasaki; Michihiro Fujiwara
Rolipram and its optical isomers, phosphodiesterase 4 inhibitors, attenuated the scopolamine-induced impairments of learning and memory in rats.
Japanese journal of pharmacology 1997;75(3):275-81.