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Yutaka Mishima

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Boron Neutron Capture Therapy

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Hiroshi Fukuda; Junichi Hiratsuka; T Kobayashi; Y Sakurai; K Yoshino; H Karashima; K Turu; K Araki; Yutaka Mishima; M Ichihashi
Boron neutron capture therapy (BNCT) for malignant melanoma with special reference to absorbed doses to the normal skin and tumor.
Masaki Iwakura; Hirohumi Kondoh; Junichi Hiratsuka; Kazumasa Ehara; Norihiko Tamaki; Yutaka Mishima
Effect of boron neutron capture therapy for melanotic and amelanotic melanoma transplanted into mouse brain.
Yutaka Mishima
New era of cell re-discovery led to the control of melanogenesis/melanoma: a scientific journey into terra incognita.

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2003: Hiroshi Fukuda; Junichi Hiratsuka; T Kobayashi; Y Sakurai; K Yoshino; H Karashima; K Turu; K Araki; Yutaka Mishima; M Ichihashi
Boron neutron capture therapy (BNCT) for malignant melanoma with special reference to absorbed doses to the normal skin and tumor.
Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine 2003;26(3):97-103.
2002: Masaki Iwakura; Hirohumi Kondoh; Junichi Hiratsuka; Kazumasa Ehara; Norihiko Tamaki; Yutaka Mishima
Effect of boron neutron capture therapy for melanotic and amelanotic melanoma transplanted into mouse brain.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2002;15(1):67-75.
2001: Yutaka Mishima
New era of cell re-discovery led to the control of melanogenesis/melanoma: a scientific journey into terra incognita.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2001;14(1):47-70.
2000: Junichi Hiratsuka; Hirohumi Kondoh; T Tsuboi; K Yoshino; Yoshinari Imajo; Yutaka Mishima
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene.
Melanoma research 2000;10(3):297-302.
2000: Junichi Hiratsuka; K Yoshino; Hirohumi Kondoh; Yoshinari Imajo; Yutaka Mishima
Biodistribution of boron concentration on melanoma-bearing hamsters after administration of p-, m-, o-boronophenylalanine.
Japanese journal of cancer research : Gann 2000;91(4):446-50.
2000: Yutaka Mishima; Hirohumi Kondoh
Dual control of melanogenesis and melanoma growth: overview molecular to clinical level and the reverse.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2000;13 Suppl 8():10-22.
1999: Eri Nishioka; Yoko Funasaka; Hirohumi Kondoh; Ashok K Chakraborty; Yutaka Mishima; Masamitsu Ichihashi
Expression of tyrosinase, TRP-1 and TRP-2 in ultraviolet-irradiated human melanomas and melanocytes: TRP-2 protects melanoma cells from ultraviolet B induced apoptosis.
Melanoma research 1999;9(5):433-43.
1999: Tatsuya Horikawa; Yutaka Mishima; K Nishino; Masamitsu Ichihashi
Horizontal and vertical pigment spread into surrounding piebald epidermis and hair follicles after suction blister epidermal grafting.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1999;12(3):175-80.
1999: Hiroshi Fukuda; C Honda; N Wadabayashi; T Kobayashi; K Yoshino; Junichi Hiratsuka; J Takahashi; T Akaizawa; Y Abe; M Ichihashi; Yutaka Mishima
Pharmacokinetics of 10B-p-boronophenylalanine in tumours, skin and blood of melanoma patients: a study of boron neutron capture therapy for malignant melanoma.
Melanoma research 1999;9(1):75-83.
1998: T Tsuboi; Hirohumi Kondoh; Junichi Hiratsuka; Yutaka Mishima
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1998;11(5):275-82.
1997: Yutaka Mishima; Yoshio Imahori; C Honda; Junichi Hiratsuka; S Ueda; Tatsuo Ido
In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue.
Journal of neuro-oncology 1997;33(1-2):163-9.
1996: H Kondoh; A Wilczek; S Narimizu; Yutaka Mishima
Mouse fibroblast expressing human tyrosinase with DHICA-oxidase activity produces predominantly pheomelanin deposit in lysosome.
Zoological science 1996;13(6):825-31.
1996: Junichi Hiratsuka; H Fukuda; T Kobayashi; K Kanda; C Honda; Masamitsu Ichihashi; Yutaka Mishima
Human melanoma treated by boron neutron capture therapy: comparison of the clinical response with the predicted response.
Radiation medicine 1996;14(5):257-63.
1996: A Wilczek; H Kondoh; Yutaka Mishima
Composition of mammalian eumelanins: analyses of DHICA-derived units in pigments from hair and melanoma cells.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1996;9(2):63-7.
1995: H Ando; A Itoh; Yutaka Mishima; Masamitsu Ichihashi
Correlation between the number of melanosomes, tyrosinase mRNA levels, and tyrosinase activity in cultured murine melanoma cells in response to various melanogenesis regulatory agents.
Journal of cellular physiology 1995;163(3):608-14.
1994: Yutaka Mishima
Melanogenesis investigation leading to selective melanoma neutron capture therapy and diagnosis.
The Journal of dermatology 1994;21(11):907-14.
1994: N Wadabayashi; C Honda; Yutaka Mishima; Masamitsu Ichihashi
Selective boron accumulation in human ocular melanoma vs surrounding eye components after 10B1-p-boronophenylalanine administration. Prerequisite for clinical trial of neutron-capture therapy.
Melanoma research 1994;4(3):185-90.
1994: Masato Ueda; Yoko Funasaka; Masamitsu Ichihashi; Yutaka Mishima
Stable and strong expression of basic fibroblast growth factor in naevus cell naevus contrasts with aberrant expression in melanoma.
The British journal of dermatology 1994;130(3):320-4.
1994: H Tsukamoto; K Hayashibe; Yutaka Mishima; Masamitsu Ichihashi
The altered expression of alpha-smooth muscle actin in basal cell epithelioma and its surrounding stroma: with special reference to proliferating cell nuclear antigen expression and adenoid differentiation.
The British journal of dermatology 1994;130(2):189-94.
1993: O Ando; Yutaka Mishima; S Hanada; Y Suemoto; J Atobe; Masashi Kurimoto
Analyses of mixed melanogenesis in tyrosinase cDNA-transfected human amelanotic melanoma cells.
The Journal of investigative dermatology 1993;101(6):864-70.
1993: A Wilczek; Yutaka Mishima
Regulatory factors for polymerization of melanin monomers within coated vesicles and premelanosomes in melanoma cells.
Melanoma research 1993;3(4):255-62.
1993: M Kondoh; Masato Ueda; Masamitsu Ichihashi; Yutaka Mishima
Decreased expression of human melanoma-associated antigen ME491 along the progression of melanoma pre-canceroses to invasive and metastatic melanomas.
Melanoma research 1993;3(4):241-5.
1993: Yutaka Mishima
The diagnosis and treatment of malignant melanoma with special reference to neutron capture therapy.
Melanoma research 1993;3(4):225-6.
1993: Y Ohyama; Yutaka Mishima
Isolation and characterization of high molecular weight melanogenic inhibitors naturally occurring in melanoma cells.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1993;6(1):7-12.
1993: Masahiro Oka; K Ogita; Naoaki Saito; Yutaka Mishima
Selective increase of the alpha subspecies of protein kinase C and inhibition of melanogenesis induced by retinoic acid in melanoma cells.
The Journal of investigative dermatology 1993;100(2 Suppl):204S-208S.
1993: M Inazu; Yutaka Mishima
Detection of eumelanogenic and pheomelanogenic melanosomes in the same normal human melanocyte.
The Journal of investigative dermatology 1993;100(2 Suppl):172S-175S.
1993: S Ando; O Ando; Y Suemoto; Yutaka Mishima
Tyrosinase gene transcription and its control by melanogenic inhibitors.
The Journal of investigative dermatology 1993;100(2 Suppl):150S-155S.
1992: M Tani; N Ishii; M Kumagai; M Ban; A Sasase; Yutaka Mishima
Malignant Langerhans cell tumour.
The British journal of dermatology 1992;126(4):398-403.
1992: T Jimbo; Masamitsu Ichihashi; Yutaka Mishima; Y Fujiwara
Role of excision repair in UVB-induced depletion and recovery of human epidermal Langerhans cells.
Archives of dermatology 1992;128(1):61-7.
1992: H Tsukamoto; Yutaka Mishima; K Hayashibe; A Sasase
Alpha-smooth muscle actin expression in tumor and stromal cells of benign and malignant human pigment cell tumors.
The Journal of investigative dermatology 1992;98(1):116-20.
1992: A Komura; T Nakagawa; Masamitsu Ichihashi; Yutaka Mishima
Thermal neutron capture therapy of malignant melanoma using 10B-monoclonal antibodies: in vitro and in vivo analysis.
Melanoma research 1992;1(5-6):397-403.
1992: Yutaka Mishima
A post melanosomal era: control of melanogenesis and melanoma growth.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1992;Suppl 2():3-16.
1991: A Ito; C Tanaka; T Takeuchi; Yutaka Mishima
Glucocorticoid stimulates melanogenesis and tyrosinase gene expression in B16 melanoma cells.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1991;4(5-6):247-51.
1991: Junichi Hiratsuka; H Fukuda; T Kobayashi; H Karashima; K Yoshino; Y Imajo; Yutaka Mishima
The relative biological effectiveness of 10B-neutron capture therapy for early skin reaction in the hamster.
Radiation research 1991;128(2):186-91.
1991: K Yamamura; S Takasaki; Masamitsu Ichihashi; Yutaka Mishima; Akira Kobata
Increase of sialylated tetraantennary sugar chains in parallel to the higher lung-colonizing abilities of mouse melanoma clones.
The Journal of investigative dermatology 1991;97(4):735-41.
1991: Ashok K Chakraborty; Masamitsu Ichihashi; Yutaka Mishima
Effect of dopa-loading on glutathione metabolising enzymes and tyrosinase in relation to 5-S-cysteinyl-dopa genesis in cultured B-16 melanoma cells.
Journal of dermatological science 1991;2(5):329-35.
1991: Tatsuya Horikawa; K Nishino; Yutaka Mishima
Melanocyte growth factor in normal human skin.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1991;4(1):48-51.
1990: H Ando; Masahiro Oka; Masamitsu Ichihashi; Yutaka Mishima
Protein kinase C and linoleic acid-induced inhibition of melanogenesis.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1990;3(4):200-6.
1990: K Yamamura; Yutaka Mishima
Antigen dynamics in melanocytic and nevocytic melanoma oncogenesis: anti-ganglioside and anti-ras p21 antibodies as markers of tumor progression.
The Journal of investigative dermatology 1990;94(2):174-82.
1990: C Honda; Yutaka Mishima; Masamitsu Ichihashi; S Hatta
In situ detection of cutaneous melanoma by prompt gamma-ray spectrometry using melanoma-seeking 10B-dopa analogue.
Journal of dermatological science 1990;1(1):23-31.
1989: T Hiramoto; T Matsunaga; Masamitsu Ichihashi; O Nikaido; Y Fujiwara; Yutaka Mishima
Repair of 254 nm ultraviolet-induced (6-4) photoproducts: monoclonal antibody recognition and differential defects in xeroderma pigmentosum complementation groups A, D, and variant.
The Journal of investigative dermatology 1989;93(5):703-6.
1989: Ashok K Chakraborty; Yutaka Mishima; M Inazu; S Hatta; Masamitsu Ichihashi
Melanogenic regulatory factors in coated vesicles from melanoma cells.
The Journal of investigative dermatology 1989;93(5):616-20.
1989: A Sasase; Yutaka Mishima; Masamitsu Ichihashi; S Taniguchi
Biochemical analysis of metastasis-related Ax actin in B16 mouse melanoma cells after chemical reversional modulation and of tumor progression-related A' actin in the ontogeny of human malignant melanoma.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(6):493-501.
1989: Yutaka Mishima; C Honda; Masamitsu Ichihashi; Hidefumi Obara; Junichi Hiratsuka; H Fukuda; H Karashima; T Kobayashi; K Kanda; K Yoshino
Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound.
Lancet 1989;2(8659):388-9.
1989: H Fukuda; T Kobayashi; Junichi Hiratsuka; H Karashima; C Honda; K Yamamura; Masamitsu Ichihashi; K Kanda; Yutaka Mishima
Estimation of absorbed dose in the covering skin of human melanoma treated by neutron capture therapy.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):365-9.
1989: Junichi Hiratsuka; M Kono; Yutaka Mishima
RBEs of thermal neutron capture therapy and 10B(n, alpha)7 Li reaction on melanoma-bearing hamsters.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):352-5.
1989: J Shirakawa; Hidefumi Obara; S Iwai; S Hatta; C Honda; Yutaka Mishima
Distant anesthetic management for neutron capture therapy.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):349-51.
1989: Masamitsu Ichihashi; A Sasase; T Hiramoto; Yoko Funasaka; S Hatta; Yutaka Mishima; T Kobayashi; H Fukuda; K Yoshino
Relative biological effectiveness (RBE) of thermal neutron capture therapy of cultured B-16 melanoma cells preincubated with 10B-paraboronophenylalanine.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):325-9.
1989: T Kobayashi; S Hatta; C Honda; K Yamamura; T Akiyoshi; K Kanda; Yutaka Mishima
Estimation of absorbed doses in human malignant melanoma treated by neutron capture therapy with special references to vertical direction.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):361-4.
1989: H Fukuda; Masamitsu Ichihashi; T Kobayashi; D Matsuzawa; K Kanda; Yutaka Mishima
Review: biological effectiveness of thermal neutrons and 10B(n,alpha)7Li reaction on cultured cells.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):333-6.
1989: Yutaka Mishima; Masamitsu Ichihashi; S Hatta; C Honda; K Yamamura; T Nakagawa
New thermal neutron capture therapy for malignant melanoma: melanogenesis-seeking 10B molecule-melanoma cell interaction from in vitro to first clinical trial.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):226-34.
1989: A Komura; T Tokuhisa; T Nakagawa; A Sasase; Masamitsu Ichihashi; S Ferrone; Yutaka Mishima
Specific killing of human melanoma cells with an efficient 10B-compound on monoclonal antibodies.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1989;2(4):259-63.
1989: Yutaka Mishima; Masamitsu Ichihashi; M Tsuji; S Hatta; Masato Ueda; C Honda; T Suzuki
Treatment of malignant melanoma by selective thermal neutron capture therapy using melanoma-seeking compound.
The Journal of investigative dermatology 1989;92(5 Suppl):321S-325S.
1989: Yutaka Mishima; Masamitsu Ichihashi; S Hatta; C Honda; K Yamamura; T Nakagawa; Hidefumi Obara; J Shirakawa; Junichi Hiratsuka; K Taniyama
First human clinical trial of melanoma neutron capture. Diagnosis and therapy.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1989;165(2-3):251-4.
1989: Masamitsu Ichihashi; A Sasase; T Hiramoto; Yutaka Mishima; H Fukuda; T Kobayashi
RBE of thermal neutron capture therapy using 10B1-para-boronophenylalanine for human and B-16 melanoma cells.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1989;165(2-3):198-201.
1989: Yutaka Mishima; Masamitsu Ichihashi; S Hatta; C Honda; A Sasase; K Yamamura; K Kanda; T Kobayashi; H Fukuda
Selective thermal neutron capture therapy and diagnosis of malignant melanoma: from basic studies to first clinical treatment.
Basic life sciences 1989;50():251-60.
1988: S Hatta; Yutaka Mishima; Masamitsu Ichihashi; S Ito
Melanin monomers within coated vesicles and premelanosomes in melanin synthesizing cells.
The Journal of investigative dermatology 1988;91(2):181-4.
1988: C Chakraborty; S Hatta; Masamitsu Ichihashi; K Hayashibe; Yutaka Mishima
Effects of L-glutamine on tyrosinase and gamma-glutamyl transpeptidase of B-16 melanoma cells in culture.
The Journal of dermatology 1988;15(1):1-6.
1988: Yutaka Mishima; Masamitsu Ichihashi; K Hayashibe; Masato Ueda; S Hatta; Yoko Funasaka; G Imokawa
Control of melanogenesis and melanoma oncogenesis.
Progress in clinical and biological research 1988;256():127-41.
1988: Yutaka Mishima; S Hatta; Y Ohyama; M Inazu
Induction of melanogenesis suppression: cellular pharmacology and mode of differential action.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1988;1(6):367-74.
1988: Yoko Funasaka; Yutaka Mishima; Masamitsu Ichihashi; T Sugiyama
Comparative analysis of oncogene expression and chromosome abnormalities between metastatic and nonmetastatic B16 melanoma clones.
Dermatologica 1988;177(4):200-11.