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Aleksandra Misicka

Research Profile

Chemicals & Drugs

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Sergiusz Markowicz; Aleksandra Misicka; Zbigniew I Nowecki; Hanna Polowniak-Pracka; Piotr Rutkowski; Henryk Skurzak; Tomasz Switaj; Marzena Biernacka; Anna Jakubowska-Mucka; Andrzej W Lipkowski; Jan Walewski
Adjuvant vaccination with melanoma antigen-pulsed dendritic cells in stage III melanoma patients.
István Ilisz; Zoltán Pataj; Róbert Berkecz; Aleksandra Misicka; Dagmara Tymecka; Ferenc FüLöp; Hee Jung Choi; Myung Ho Hyun; Antal Péter
High-performance liquid chromatographic enantioseparation of beta(2)-amino acids using a long-tethered (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase.
Karolina Pulka; Debby Feytens; Aleksandra Misicka; Dirk Tourwé
New tetracyclic tetrahydro-beta-carbolines as tryptophan-derived peptidomimetics.

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All Publications

2012: Sergiusz Markowicz; Aleksandra Misicka; Zbigniew I Nowecki; Hanna Polowniak-Pracka; Piotr Rutkowski; Henryk Skurzak; Tomasz Switaj; Marzena Biernacka; Anna Jakubowska-Mucka; Andrzej W Lipkowski; Jan Walewski
Adjuvant vaccination with melanoma antigen-pulsed dendritic cells in stage III melanoma patients.
Medical oncology (Northwood, London, England) 2012;29(4):2966-77.
2010: István Ilisz; Zoltán Pataj; Róbert Berkecz; Aleksandra Misicka; Dagmara Tymecka; Ferenc FüLöp; Hee Jung Choi; Myung Ho Hyun; Antal Péter
High-performance liquid chromatographic enantioseparation of beta(2)-amino acids using a long-tethered (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase.
Journal of chromatography. A 2010;1217(7):1075-82.
2010: Karolina Pulka; Debby Feytens; Aleksandra Misicka; Dirk Tourwé
New tetracyclic tetrahydro-beta-carbolines as tryptophan-derived peptidomimetics.
Molecular diversity 2010;14(1):97-108.
2009: Zoltán Pataj; Róbert Berkecz; István Ilisz; Aleksandra Misicka; Dagmara Tymecka; Ferenc FüLöp; Daniel W Armstrong; Antal Péter
High-performance liquid chromatographic chiral separation of beta2-homoamino acids.
Chirality 2009;21(9):787-98.
2009: Róbert Berkecz; István Ilisz; Aleksandra Misicka; Dagmara Tymecka; Ferenc FüLöp; Hee Jung Choi; Myung Ho Hyun; Antal Péter
HPLC enantioseparation of beta2-homoamino acids using crown ether-based chiral stationary phase.
Journal of separation science 2009;32(7):981-7.
2008: Zoltán Pataj; István Ilisz; Róbert Berkecz; Aleksandra Misicka; Dagmara Tymecka; Ferenc FüLöp; Daniel W Armstrong; Antal Péter
Comparison of performance of Chirobiotic T, T2 and TAG columns in the separation of beta2- and beta3-homoamino acids.
Journal of separation science 2008;31(21):3688-97.
2008: Steven Ballet; Aleksandra Misicka; Piotr Kosson; Carole Lemieux; Nga N Chung; Peter W Schiller; Andrzej W Lipkowski; Dirk Tourwé
Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.
Journal of medicinal chemistry 2008;51(8):2571-4.
2008: Aneta Lukaszuk; Heidi Demaegdt; Erzsebet Szemenyei; Géza Tóth; Dagmara Tymecka; Aleksandra Misicka; Philippe Karoyan; Patrick M L Vanderheyden; Georges Vauquelin; Dirk Tourwé
Beta-homo-amino acid scan of angiotensin IV.
Journal of medicinal chemistry 2008;51(7):2291-6.
2007: Steven Ballet; Alexander V Mayorov; Minying Cai; Dagmara Tymecka; Kevin B Chandler; Erin S Palmer; Karolien Van Rompaey; Aleksandra Misicka; Dirk Tourwé; Victor J Hruby
Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold.
Bioorganic & medicinal chemistry letters 2007;17(9):2492-8.
2006: Slawomir Sek; Aleksandra Misicka; Karolina Swiatek; Elwira Maicka
Conductance of alpha-helical peptides trapped within molecular junctions.
The journal of physical chemistry. B 2006;110(39):19671-7.
2006: Marcin Karbarz; Karolina Pulka; Aleksandra Misicka; Zbigniew Stojek
pH and temperature-sensitive N-isopropylacrylamide ampholytic networks incorporating L-lysine.
Langmuir : the ACS journal of surfaces and colloids 2006;22(18):7843-7.
2005: Slawomir Sek; Karolina Swiatek; Aleksandra Misicka
Electrical behavior of molecular junctions incorporating alpha-helical peptide.
The journal of physical chemistry. B 2005;109(49):23121-4.
2005: Slawomir Sek; Anna Tolak; Aleksandra Misicka; Barbara Palys; Renata Bilewicz
Asymmetry of electron transmission through monolayers of helical polyalanine adsorbed on gold surfaces.
The journal of physical chemistry. B 2005;109(39):18433-8.
2004: Hanna Kruszewska; Aleksandra Misicka; Urszula Chmielowiec
Biodegradation of DNA and nucleotides to nucleosides and free bases.
Farmaco (Società chimica italiana : 1989) 2004;59(1):13-20.
2003: V Boguslavsky; Victor J Hruby; David F O'Brien; Aleksandra Misicka; Andrzej W Lipkowski
Effect of peptide conformation on membrane permeability.
The journal of peptide research : official journal of the American Peptide Society 2003;61(6):287-97.
2002: Vincent S Hau; Jason D Huber; Christopher R Campos; Andrzej W Lipkowski; Aleksandra Misicka; Thomas P Davis
Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II.
Journal of pharmaceutical sciences 2002;91(10):2140-9.
2002: Judith L Flippen-Anderson; Jeffrey Deschamps; Clifford George; V J Hruby; Aleksandra Misicka; Andrzej W Lipkowski
Crystal structure of biphalin sulfate: a multireceptor opioid peptide.
The journal of peptide research : official journal of the American Peptide Society 2002;59(3):123-33.
2002: Andrzej W Lipkowski; Aleksandra Misicka; Dariusz Kosson; Piotr Kosson; Magdalena Lachwa-From; Agnieszka Brodzik-Bienkowska; Victor J Hruby
Biological properties of a new fluorescent biphalin fragment analogue.
Life sciences 2002;70(8):893-7.
2001: Bozena Szaniawska; Halina Trembacz; Joanna Miloszewska; Andrzej W Lipkowski; Aleksandra Misicka; J Ostrowski; Przemyslaw Janik
Peptide analog of fibronectin that inhibits cell migration and ERK 1/2 activity.
Peptides 2001;22(12):1949-53.
2001: Andrzej W Lipkowski; Aleksandra Misicka; Keiko Hosohata; Peg Davis; Henry I Yamamura; Frank Porreca; Victor J Hruby
Biological properties of Phe(o)-opioid peptide analogues.
Life sciences 2001;68(8):969-72.
2000: Stacy E Foran; Daniel B Carr; Andrzej W Lipkowski; I Maszczynska; James E Marchand; Aleksandra Misicka; Martin Beinborn; Alan Kopin; RM Kream
Inhibition of morphine tolerance development by a substance P-opioid peptide chimera.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1142-8.
2000: Stacy E Foran; D B Carr; A W Lipkowski; I Maszczynska; J E Marchand; Aleksandra Misicka; Martin Beinborn; Alan Kopin; RM Kream
A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7621-6.
2000: Ryszard Pluta; Aleksandra Misicka; Maria Barcikowska; S Spisacka; Andrzej W Lipkowski; S Januszewski
Possible reverse transport of beta-amyloid peptide across the blood-brain barrier.
Acta neurochirurgica. Supplement 2000;76():73-7.
1999: Ryszard Pluta; Maria Barcikowska; Aleksandra Misicka; Andrzej W Lipkowski; S Spisacka; S Januszewski
Ischemic rats as a model in the study of the neurobiological role of human beta-amyloid peptide. Time-dependent disappearing diffuse amyloid plaques in brain.
Neuroreport 1999;10(17):3615-9.
1999: Andrzej W Lipkowski; Aleksandra Misicka; Peg Davis; Dagmar Stropova; J Janders; M Lachwa; Frank Porreca; Henry I Yamamura; Victor J Hruby
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin.
Bioorganic & medicinal chemistry letters 1999;9(18):2763-6.
1998: G Li; W Haq; L Xiang; B S Lou; R Hughes; I A De Leon; Peg Davis; TJ Gillespie; Marek Romanowski; Xiaoyun Zhu; Aleksandra Misicka; Andrzej W Lipkowski; Frank Porreca; Thomas P Davis; Henry I Yamamura; David F O'Brien; Victor J Hruby
Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.
Bioorganic & medicinal chemistry letters 1998;8(5):555-60.
1998: J Slaninova; Suzanne M Appleyard; Aleksandra Misicka; Andrzej W Lipkowski; Richard J Knapp; S J Weber; Thomas P Davis; Henry I Yamamura; Victor J Hruby
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
Life sciences 1998;62(14):PL199-204.
1997: Marek Romanowski; Xiaoyun Zhu; V Ramaswami; Aleksandra Misicka; Andrzej W Lipkowski; Victor J Hruby; David F O'Brien
Interaction of a highly potent dimeric enkephalin analog, biphalin, with model membranes.
Biochimica et biophysica acta 1997;1329(2):245-58.
1997: Aleksandra Misicka; S Cavagnero; R Horvath; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1997;50(1):48-54.
1997: Ryszard Pluta; Aleksandra Misicka; S Januszewski; Maria Barcikowska; Andrzej W Lipkowski
Transport of human beta-amyloid peptide through the rat blood-brain barrier after global cerebral ischemia.
Acta neurochirurgica. Supplement 1997;70():247-9.
1997: Aleksandra Misicka; Andrzej W Lipkowski; R Horvath; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.
Life sciences 1997;60(15):1263-9.
1996: V Ramaswami; X Zhu; Marek Romanowski; R C Haaseth; Aleksandra Misicka; Andrzej W Lipkowski; Victor J Hruby; David F O'Brien
Lipid membrane permeability of modified c[D-Pen2, D-Pen5]enkephalin peptides.
International journal of peptide and protein research 1996;48(1):87-94.
1996: D L Greene; Vincent S Hau; Thomas J Abbruscato; H Bartosz; Aleksandra Misicka; Andrzej W Lipkowski; S Hom; TJ Gillespie; Victor J Hruby; Thomas P Davis
Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1366-75.
1996: Ryszard Pluta; Maria Barcikowska; S Januszewski; Aleksandra Misicka; Andrzej W Lipkowski
Evidence of blood-brain barrier permeability/leakage for circulating human Alzheimer's beta-amyloid-(1-42)-peptide.
Neuroreport 1996;7(7):1261-5.
1996: Thomas J Abbruscato; S A Williams; Aleksandra Misicka; Andrzej W Lipkowski; Victor J Hruby; Thomas P Davis
Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives.
The Journal of pharmacology and experimental therapeutics 1996;276(3):1049-57.
1996: R Pluta; M Oseka; S Januszewski; Aleksandra Misicka; A W Lipkowski; Maria Barcikowska; E Koźniewska
Increase of cerebral blood flow in rats after human b-amyloid peptide infusion.
Folia morphologica 1996;55(4):420-1.
1996: R Pluta; Aleksandra Misicka; Maria Barcikowska; S Januszewski; A W Lipkowski
A promising rat model of Alzheimer's disease-like neuropathology.
Folia morphologica 1996;55(4):417-9.
1996: Aleksandra Misicka; I Maszczynska; Andrzej W Lipkowski; Dagmar Stropova; Henry I Yamamura; V J Hruby
Synthesis and biological properties of gamma-glutamyl-dermorphin, a prodrug.
Life sciences 1996;58(11):905-11.
1995: Aleksandra Misicka
Peptide and nonpeptide ligands for opioid receptors.
Acta poloniae pharmaceutica 1995;52(5):349-63.
1995: Aleksandra Misicka; Andrzej W Lipkowski; J Slaninova; P Davis; Henry I Yamamura; F Porreca; Victor J Hruby
The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2.
Life sciences 1995;57(18):1633-40.
1994: Aleksandra Misicka; Andrzej W Lipkowski; R Horvath; P Davis; F Porreca; Henry I Yamamura; Victor J Hruby
Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.
International journal of peptide and protein research 1994;44(6):607.
1994: Aleksandra Misicka; Andrzej W Lipkowski; R Horvath; P Davis; F Porreca; Henry I Yamamura; Victor J Hruby
Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.
International journal of peptide and protein research 1994;44(1):80-4.
1994: X Qian; K E Kövér; MD Shenderovich; B S Lou; Aleksandra Misicka; T Zalewska; R Horváth; P Davis; E J Bilsky; F Porreca
Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors.
Journal of medicinal chemistry 1994;37(12):1746-57.
1994: Aleksandra Misicka; Andrzej W Lipkowski; R Horvath; P Davis; Henry I Yamamura; F Porreca; Victor J Hruby
Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
Journal of medicinal chemistry 1994;37(1):141-5.
1993: S J Weber; Thomas J Abbruscato; E A Brownson; Andrzej W Lipkowski; Robin Polt; Aleksandra Misicka; R C Haaseth; H Bartosz; Victor J Hruby; Thomas P Davis
Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1649-55.
1993: K D Wild; P J Horan; Aleksandra Misicka; Andrzej W Lipkowski; R C Haaseth; T O Matsunaga; Victor J Hruby; G Toth; A Borsodi; Henry I Yamamura
Pseudoirreversible binding characteristics of [D-Ala2,Glu4]deltorphin and its Cys4 substituted derivative to delta-opioid receptors.
European journal of pharmacology 1993;246(1):25-31.
1993: P J Horan; A Mattia; E J Bilsky; S Weber; Thomas P Davis; Henry I Yamamura; Ewa Malatynska; Suzanne M Appleyard; J Slaninova; Aleksandra Misicka
Antinociceptive profile of biphalin, a dimeric enkephalin analog.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1446-54.
1993: P J Horan; K D Wild; Aleksandra Misicka; Andrzej W Lipkowski; R C Haaseth; Victor J Hruby; S J Weber; Thomas P Davis; Henry I Yamamura; F Porreca
Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.
The Journal of pharmacology and experimental therapeutics 1993;265(2):896-902.
1992: Aleksandra Misicka; Andrzej W Lipkowski; R Horvath; P Davis; T H Kramer; Henry I Yamamura; Victor J Hruby
Topographical requirements for delta opioid ligands: common structural features of dermenkephalin and deltorphin.
Life sciences 1992;51(13):1025-32.
1991: Aleksandra Misicka; Andrzej W Lipkowski; L Fang; Richard J Knapp; P Davis; T Kramer; T F Burks; Henry I Yamamura; D B Carr; Victor J Hruby
Topographical requirements for delta opioid ligands: presence of a carboxyl group in position 4 is not critical for deltorphin high delta receptor affinity and analgesic activity.
Biochemical and biophysical research communications 1991;180(3):1290-7.
1991: S Cavagnero; Aleksandra Misicka; Richard J Knapp; P Davis; L Fang; T F Burks; Henry I Yamamura; Victor J Hruby
Delta opioid receptor-selective ligands: [D-Pen2,D-Pen5]enkephalin-dermenkephalin chimeric peptides.
Life sciences 1991;49(7):495-503.
1989: A W Lipkowski; Aleksandra Misicka
[Interrelations between the enzyme system and the action of neuropeptides].
Acta physiologica Polonica 1989;40 Suppl 34():29-43.