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Ihor Misko

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Human Herpesvirus 4

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John J Miles; Sharon L Silins; Andrew G Brooks; Joanne E Davis; Ihor Misko; Scott R Burrows
T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years.
Sharon L Silins; Martina A Sherritt; J M Silleri; SM Cross; Suzanne L Elliott; Mandvi Bharadwaj; T T Le; Leanne E Morrison; Rajiv Khanna; Denis Moss; A Suhrbier; Ihor Misko
Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load.
Kevin Spring; S Cross; C Li; Dianne Watters; L Ben-Senior; P Waring; F Ahangari; S L Lu; Philip Chen; Ihor Misko; C Paterson; G Kay; Nechama I Smorodinsky; Yosef Shiloh; Martin F Lavin
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.

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All Publications

2005: John J Miles; Sharon L Silins; Andrew G Brooks; Joanne E Davis; Ihor Misko; Scott R Burrows
T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years.
Blood 2005;106(13):4412-3.
2001: Sharon L Silins; Martina A Sherritt; J M Silleri; SM Cross; Suzanne L Elliott; Mandvi Bharadwaj; T T Le; Leanne E Morrison; Rajiv Khanna; Denis Moss; A Suhrbier; Ihor Misko
Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load.
Blood 2001;98(13):3739-44.
2001: Kevin Spring; S Cross; C Li; Dianne Watters; L Ben-Senior; P Waring; F Ahangari; S L Lu; Philip Chen; Ihor Misko; C Paterson; G Kay; Nechama I Smorodinsky; Yosef Shiloh; Martin F Lavin
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.
Cancer research 2001;61(11):4561-8.
2001: Denis Moss; Scott R Burrows; Sharon L Silins; Ihor Misko; Rajiv Khanna
The immunology of Epstein-Barr virus infection.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1408):475-88.
1999: Toshiyuki Fukao; Hideo Kaneko; Geoff W Birrell; Magtouf Gatei; H Tashita; T Yoshida; S Cross; Padmini Kedar; Dianne Watters; K K Khana; Ihor Misko; Naomi Kondo; Martin F Lavin
ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells.
Blood 1999;94(6):1998-2006.
1999: Ihor Misko; SM Cross; Rajiv Khanna; Suzanne L Elliott; C Schmidt; SJ Pye; Sharon L Silins
Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2279-84.
1998: Sharon L Silins; SM Cross; Kenia G Krauer; Denis Moss; Christopher W Schmidt; Ihor Misko
A functional link for major TCR expansions in healthy adults caused by persistent Epstein-Barr virus infection.
The Journal of clinical investigation 1998;102(8):1551-8.
1998: E G Zhao; Q Song; S Cross; Ihor Misko; Susan Lees-Miller; Martin F Lavin
Resistance to etoposide-induced apoptosis in a Burkitt's lymphoma cell line.
International journal of cancer. Journal international du cancer 1998;77(5):755-62.
1998: Scott A Thomson; Scott R Burrows; Ihor Misko; Denis Moss; Barbara E H Coupar; Rajiv Khanna
Targeting a polyepitope protein incorporating multiple class II-restricted viral epitopes to the secretory/endocytic pathway facilitates immune recognition by CD4+ cytotoxic T lymphocytes: a novel approach to vaccine design.
Journal of virology 1998;72(3):2246-52.
1998: Kay A O Ellem; Christopher W Schmidt; C L Li; Ihor Misko; A Kelso; G Sing; G Macdonald; Michael G E O'Rourke
The labyrinthine ways of cancer immunotherapy--T cell, tumor cell encounter: "how do I lose thee? Let me count the ways".
Advances in cancer research 1998;75():203-49.
1997: Sharon L Silins; SM Cross; Suzanne L Elliott; SJ Pye; Jacqueline M Burrows; Denis Moss; Ihor Misko
Selection of a diverse TCR repertoire in response to an Epstein-Barr virus-encoded transactivator protein BZLF1 by CD8+ cytotoxic T lymphocytes during primary and persistent infection.
International immunology 1997;9(11):1745-55.
1997: Suzanne L Elliott; SJ Pye; C Schmidt; SM Cross; Sharon L Silins; Ihor Misko
Dominant cytotoxic T lymphocyte response to the immediate-early trans-activator protein, BZLF1, in persistent type A or B Epstein-Barr virus infection.
The Journal of infectious diseases 1997;176(4):1068-72.
1997: Norbert Kienzle; S Cross; DB Young; Ihor Misko; Tom Sculley; C S Abrams
Evidence that the expression and phosphorylation status of pleckstrin is modulated by Epstein-Barr virus in human B lymphocytes.
Blood 1997;89(9):3488-90.
1997: Kay A O Ellem; Michael G E O'Rourke; G R Johnson; G Parry; Ihor Misko; Christopher W Schmidt; Peter G Parsons; Scott R Burrows; S Cross; AH Fell; C L Li; J R Bell; P J Dubois; Denis Moss; Michael F Good; A Kelso; LK Cohen; Glenn Dranoff; Richard C Mulligan
A case report: immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy.
Cancer immunology, immunotherapy : CII 1997;44(1):10-20.
1996: Sharon L Silins; SM Cross; Suzanne L Elliott; SJ Pye; Scott R Burrows; Jacqueline M Burrows; Denis Moss; V P Argaet; Ihor Misko
Development of Epstein-Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis.
The Journal of experimental medicine 1996;184(5):1815-24.
1996: C A White; SM Cross; Michael Kurilla; B M Kerr; C Schmidt; Ihor Misko; Rajiv Khanna; Denis Moss
Recruitment during infectious mononucleosis of CD3+CD4+CD8+ virus-specific cytotoxic T cells which recognise Epstein-Barr virus lytic antigen BHRF1.
Virology 1996;219(2):489-92.
1995: Christopher W Schmidt; Ihor Misko
The ecology and pathology of Epstein-Barr virus.
Immunology and cell biology 1995;73(6):489-504.
1995: Scott R Burrows; Sharon L Silins; Denis Moss; Rajiv Khanna; Ihor Misko; V P Argaet
T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen.
The Journal of experimental medicine 1995;182(6):1703-15.
1994: V P Argaet; Christopher W Schmidt; Scott R Burrows; Sharon L Silins; Michael Kurilla; D L Doolan; Andreas Suhrbier; Denis Moss; Elliott Kieff; Tom Sculley; Ihor Misko
Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.
The Journal of experimental medicine 1994;180(6):2335-40.
1993: Rajiv Khanna; Scott R Burrows; Andreas Suhrbier; C A Jacob; H Griffin; Ihor Misko; Tom Sculley; Martin Rowe; A B Rickinson; Denis Moss
EBV peptide epitope sensitization restores human cytotoxic T cell recognition of Burkitt's lymphoma cells. Evidence for a critical role for ICAM-2.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5154-62.
1992: Rajiv Khanna; Scott R Burrows; Michael Kurilla; C A Jacob; Ihor Misko; Tom Sculley; Elliott Kieff; Denis Moss
Localization of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development.
The Journal of experimental medicine 1992;176(1):169-76.
1992: Denis Moss; Scott R Burrows; Rajiv Khanna; Ihor Misko; Tom Sculley
Immune surveillance against Epstein-Barr virus.
Seminars in immunology 1992;4(2):97-104.
1992: Ihor Misko; C Schmidt; Margo Honeyman; T D Soszynski; Tom Sculley; Scott R Burrows; Denis Moss; K Burman
Failure of Epstein-Barr virus-specific cytotoxic T lymphocytes to lyse B cells transformed with the B95-8 strain is mapped to an epitope that associates with the HLA-B8 antigen.
Clinical and experimental immunology 1992;87(1):65-70.
1992: A Apolloni; D Moss; R Stumm; S Burrows; A Suhrbier; Ihor Misko; C Schmidt; Tom Sculley
Sequence variation of cytotoxic T cell epitopes in different isolates of Epstein-Barr virus.
European journal of immunology 1992;22(1):183-9.
1991: Rajiv Khanna; C A Jacob; Scott R Burrows; Michael Kurilla; Elliott Kieff; Ihor Misko; Tom Sculley; Denis Moss
Expression of Epstein-Barr virus nuclear antigens in anti-IgM-stimulated B cells following recombinant vaccinia infection and their recognition by human cytotoxic T cells.
Immunology 1991;74(3):504-10.
1991: C Schmidt; Scott R Burrows; Tom Sculley; Denis Moss; Ihor Misko
Nonresponsiveness to an immunodominant Epstein-Barr virus-encoded cytotoxic T-lymphocyte epitope in nuclear antigen 3A: implications for vaccine strategies.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9478-82.
1991: C Schmidt; Scott R Burrows; Denis Moss; Tom Sculley; Ihor Misko
Oligopeptide induction of a secondary cytotoxic T-cell response to Epstein-Barr virus in vitro.
Scandinavian journal of immunology 1991;33(4):411-20.
1991: Ihor Misko; Tom Sculley; C Schmidt; Denis Moss; T Soszynski; K Burman
Composite response of naive T cells to stimulation with the autologous lymphoblastoid cell line is mediated by CD4 cytotoxic T cell clones and includes an Epstein-Barr virus-specific component.
Cellular immunology 1991;132(2):295-307.
1991: Ihor Misko; C Schmidt; Denis Moss; Scott R Burrows; Tom Sculley
Cytotoxic T lymphocyte discrimination between type A Epstein-Barr virus transformants is mapped to an immunodominant epitope in EBNA 3.
The Journal of general virology 1991;72 ( Pt 2)():405-9.
1991: Denis Moss; Ihor Misko; Tom Sculley; A Apolloni; Rajiv Khanna; Scott R Burrows
Immune regulation of Epstein-Barr virus (EBV): EBV nuclear antigen as a target for EBV-specific T cell lysis.
Springer seminars in immunopathology 1991;13(2):147-56.
1990: Ihor Misko; C Schmidt; N Martin; Denis Moss; Tom Sculley; S Burrows; K J Burman
Lymphokine-activated killer (LAK) cells discriminate between Epstein-Barr virus (EBV)-positive Burkitt's lymphoma cells.
International journal of cancer. Journal international du cancer 1990;46(3):399-404.
1990: Scott R Burrows; Ihor Misko; Tom Sculley; C Schmidt; Denis Moss
An Epstein-Barr virus-specific cytotoxic T-cell epitope present on A- and B-type transformants.
Journal of virology 1990;64(8):3974-6.
1990: Scott R Burrows; Ihor Misko; Tom Sculley; C Schmidt; D Gang; Denis Moss
Patterns of reactivity of Epstein-Barr virus-specific T cells in A-type donor cultures after reactivation with autologous A- or B-type transformants.
Cellular immunology 1990;127(1):47-55.
1990: Scott R Burrows; Tom Sculley; Ihor Misko; C Schmidt; Denis Moss
An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3).
The Journal of experimental medicine 1990;171(1):345-9.
1989: C Schmidt; K Burman; D J Moss; J Ryan; Scott R Burrows; Ihor Misko
Interleukin-2 receptors in infectious mononucleosis.
Immunology letters 1989;23(2):139-42.
1989: Tom Sculley; A Apolloni; R Stumm; Denis Moss; N Mueller-Lantczh; Ihor Misko; David A Cooper
Expression of Epstein-Barr virus nuclear antigens 3, 4, and 6 are altered in cell lines containing B-type virus.
Virology 1989;171(2):401-8.
1989: Ihor Misko; Scott R Burrows; C Schmidt; C J Bishop; J M Ryan; J A Staples; Denis Moss
T lymphocytes in infectious mononucleosis; effect of IL-2 on the outgrowth of Epstein-Barr virus-infected cells.
Immunology and cell biology 1989;67 ( Pt 1)():49-55.
1988: Denis Moss; Ihor Misko; Scott R Burrows; K Burman; R McCarthy; Tom Sculley
Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr virus transformants.
Nature 1988;331(6158):719-21.
1984: Ihor Misko; T D Soszynski; R G Kane; J H Pope
Factors influencing the human cytotoxic T cell response to autologous lymphoblastoid cell lines in vitro.
Clinical immunology and immunopathology 1984;32(3):285-97.
1984: Ihor Misko; J H Pope; R Hütter; T D Soszynski; R G Kane
HLA-DR-antigen-associated restriction of EBV-specific cytotoxic T-cell colonies.
International journal of cancer. Journal international du cancer 1984;33(2):239-43.
1982: Ihor Misko; J H Pope; R G Kane; H Bashir; T Doran
Evidence for the involvement of HLA-DR antigens in restricted cytotoxicity by fetal calf serum-specific human T cells.
Human immunology 1982;5(3):183-97.
1982: Ihor Misko; R G Kane; J H Pope
Generation in vitro of HLA-restricted EB virus-specific cytotoxic human T cells by autologous lymphoblastoid cell lines: the role of previous EB virus infection and foetal calf serum.
International journal of cancer. Journal international du cancer 1982;29(1):41-8.
1981: A B Rickinson; D J Moss; L E Wallace; M Rowe; Ihor Misko; M A Epstein; J H Pope
Long-term T-cell-mediated immunity to Epstein-Barr virus.
Cancer research 1981;41(11 Pt 1):4216-21.
1981: Ihor Misko; R G Kane; J H Pope
Restriction of foetal calf serum-induced cytotoxicity by human T-cells.
Immunology letters 1981;3(2):81-5.
1981: Ihor Misko; R G Kane; J H Pope
Generation in vitro of EBV-induced specific cytotoxic T cells in autologous serum avoids complications due to self-preferred foetal calf serum-specific T-cell cytotoxicity.
International journal of cancer. Journal international du cancer 1981;27(4):513-9.
1980: Ihor Misko; D J Moss; J H Pope
HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):4247-50.