FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Clint Mitchell

Research Profile

Anatomy

Tumor Cell Line

Chemicals & Drugs

Physiology

Living Beings

Phenomena

Blotting, Western

Co-author Network

Publications

TOP 3
Margaret A Park; Hossein A Hamed; Clint Mitchell; Nichola Cruickshanks; Rupesh Dash; Jeremy C Allegood; Igor P Dmitriev; Gary Tye; Besim Ogretmen; Sarah Spiegel; Adly Yacoub; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
Clint Mitchell; Adly Yacoub; Hamed Hossein; Aditi Pandya Martin; M Danielle Bareford; Patrick Eulitt; Chen Yang; Kenneth P Nephew; Paul Dent
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Clint Mitchell; Margaret Park; Patrick Eulitt; Chen Yang; Adly Yacoub; Paul Dent
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Clint Mitchell (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Margaret A Park; Hossein A Hamed; Clint Mitchell; Nichola Cruickshanks; Rupesh Dash; Jeremy C Allegood; Igor P Dmitriev; Gary Tye; Besim Ogretmen; Sarah Spiegel; Adly Yacoub; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
Molecular pharmacology 2011;79(3):368-80.
2010: Clint Mitchell; Adly Yacoub; Hamed Hossein; Aditi Pandya Martin; M Danielle Bareford; Patrick Eulitt; Chen Yang; Kenneth P Nephew; Paul Dent
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Cancer biology & therapy 2010;10(9):903-17.
2010: Clint Mitchell; Margaret Park; Patrick Eulitt; Chen Yang; Adly Yacoub; Paul Dent
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
Molecular pharmacology 2010;78(5):909-17.
2010: Anindita Das; David Durrant; Clint Mitchell; Eric Mayton; Nicholas N Hoke; Fadi Salloum; Margaret A Park; Ian Qureshi; Ray Lee; Paul Dent; Rakesh C Kukreja
Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18202-7.
2010: Teneille Walker; Clint Mitchell; Margaret A Park; Adly Yacoub; Mohamed Rahmani; Dieter Häussinger; Roland Reinehr; Christina Voelkel Johnson; Paul B Fisher; Steven Grant; Paul Dent
17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.
Molecular cancer therapeutics 2010;9(5):1378-95.
2010: Adly Yacoub; Hossein A Hamed; Jeremy C Allegood; Clint Mitchell; Sarah Spiegel; Maciej S Lesniak; Besim Ogretmen; Rupesh Dash; Devanand Sarkar; William C Broaddus; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Cancer research 2010;70(3):1120-9.
2009: Aditi Pandya Martin; Clint Mitchell; Mohamed Rahmani; Kenneth P Nephew; Steven Grant; Paul Dent
Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.
Cancer biology & therapy 2009;8(21):2084-96.
2009: Dmitri Kapitonov; Jeremy C Allegood; Clint Mitchell; Nitai C Hait; Jorge A Almenara; Jeffrey K Adams; Robert E Zipkin; Paul Dent; Tomasz Kordula; Sheldon Milstien; Sarah Spiegel
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Cancer research 2009;69(17):6915-23.
2009: Aditi Pandya Martin; Margaret A Park; Clint Mitchell; Teneille Walker; Mohamed Rahmani; Andrew Thorburn; Dieter Häussinger; Roland Reinehr; Steven Grant; Paul Dent
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Molecular pharmacology 2009;76(2):327-41.
2009: Teneille Walker; Clint Mitchell; Margaret A Park; Adly Yacoub; Martin Graf; Mohamed Rahmani; Peter J Houghton; Christina Voelkel Johnson; Steven Grant; Paul Dent
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Molecular pharmacology 2009;76(2):342-55.
2009: Martin R Graf; Wentao Jia; Ross S Johnson; Paul Dent; Clint Mitchell; Roger M Loria
Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3beta androstene 17alpha diol neuro-steroid on malignant glioma cells.
The Journal of steroid biochemistry and molecular biology 2009;115(3-5):137-45.
2008: Margaret A Park; Guo Zhang; Aditi Pandya Martin; Hossein Hamed; Clint Mitchell; Phillip B Hylemon; Martin Graf; Mohamed Rahmani; Kevin Ryan; Xiang Liu; Sarah Spiegel; James Norris; Paul B Fisher; Steven Grant; Paul Dent
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.
Cancer biology & therapy 2008;7(10):1648-62.
2008: Guo Zhang; Margaret A Park; Clint Mitchell; Teneille Walker; Hossein Hamed; Elaine Studer; Martin Graf; Mohamed Rahmani; Seema Gupta; Phillip B Hylemon; Paul B Fisher; Steven Grant; Paul Dent
Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.
The Journal of biological chemistry 2008;283(36):24343-58.
2008: Margaret A Park; Guo Zhang; Clint Mitchell; Mohamed Rahmani; Hossein Hamed; Michael P Hagan; Adly Yacoub; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Molecular cancer therapeutics 2008;7(9):2633-48.
2008: Guo Zhang; Margaret A Park; Clint Mitchell; Hossein Hamed; Mohamed Rahmani; Aditi Pandya Martin; David T Curiel; Adly Yacoub; Martin Graf; Ray Lee; John D Roberts; Paul B Fisher; Steven Grant; Paul Dent
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5385-99.
2008: Aditi Pandya Martin; Anna Miller; Luni Emad; Mohamed Rahmani; Teneille Walker; Clint Mitchell; Michael P Hagan; Margaret A Park; Adly Yacoub; Paul B Fisher; Steven Grant; Paul Dent
Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation.
Molecular pharmacology 2008;74(3):807-22.
2008: Hossein Hamed; Clint Mitchell; Margaret A Park; David Hanna; Aditi Pandya Martin; Benjamin Harrison; William Hawkins; David A Curiel; Paul B Fisher; Steven Grant; Adly Yacoub; Michael P Hagan; Paul Dent
Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo.
Cancer biology & therapy 2008;7(4):587-93.
2008: Hossein Hamed; William Hawkins; Clint Mitchell; Donna Gilfor; Guo Zhang; Xin-Yan Pei; Yun Dai; Michael P Hagan; John D Roberts; Adly Yacoub; Steven Grant; Paul Dent
Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.
Molecular cancer therapeutics 2008;7(3):616-29.
2007: Clint Mitchell; Margaret A Park; Guo Zhang; Adly Yacoub; David T Curiel; Paul B Fisher; John D Roberts; Steven Grant; Paul Dent
Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.
Molecular cancer therapeutics 2007;6(12 Pt 1):3101-12.
2007: Clint Mitchell; Peyman Kabolizadeh; John Ryan; John D Roberts; Adly Yacoub; David T Curiel; Paul B Fisher; Michael P Hagan; Nicholas Farrell; Steven Grant; Paul Dent
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
Molecular pharmacology 2007;72(3):704-14.
2007: Youwen Fang; Elaine Studer; Clint Mitchell; Steven Grant; William M Pandak; Phillip B Hylemon; Paul Dent
Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
Molecular pharmacology 2007;71(4):1122-8.
2007: Clint Mitchell; Margaret A Park; Guo Zhang; Song Iy Han; Hisashi Harada; Richard A Franklin; Adly Yacoub; Pin-Lan Li; Phillip B Hylemon; Steven Grant; Paul Dent
17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.
Molecular cancer therapeutics 2007;6(2):618-32.
2006: Adly Yacoub; Margaret A Park; David Hanna; Young Hong; Clint Mitchell; Aditi P Pandya; Hisashi Harada; Garth Powis; Ching-Shih Chen; Constantinos Koumenis; Steven Grant; Paul Dent
OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells.
Molecular pharmacology 2006;70(2):589-603.
2005: Paul Dent; Youwen Fang; Seema Gupta; Elaine Studer; Clint Mitchell; Sarah Spiegel; Phillip B Hylemon
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(6):1291-9.
2005: Paul Dent; Song Iy Han; Clint Mitchell; Elaine Studer; Adly Yacoub; Jennifer Rubin Grandis; Steven Grant; Geoffrey W Krystal; Phillip B Hylemon
Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.
Biochemical pharmacology 2005;70(11):1685-96.
2005: William Hawkins; Clint Mitchell; Robert McKinstry; Donna Gilfor; James Starkey; Yun Dai; Kathy Dawson; Viswanathan Ramakrishnan; John D Roberts; Adly Yacoub; Steven Grant; Paul Dent
Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
Cancer biology & therapy 2005;4(11):1275-84.
2005: Rubén W Carón; Adly Yacoub; Clint Mitchell; Xiaoyu Zhu; Young Hong; Takehiko Sasazuki; Senji Shirasawa; Michael P Hagan; Steven Grant; Paul Dent
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Cell cycle (Georgetown, Tex.) 2005;4(3):456-64.
2005: Yun Dai; Mohamed Rahmani; Xin-Yan Pei; Payal Khanna; Song Iy Han; Clint Mitchell; Paul Dent; Steven Grant
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Blood 2005;105(4):1706-16.
2005: Rubén W Carón; Adly Yacoub; Min Li; Xiaoyu Zhu; Clint Mitchell; Young Hong; William Hawkins; Takehiko Sasazuki; Senji Shirasawa; Alan P Kozikowski; Philip A Dennis; Michael P Hagan; Steven Grant; Paul Dent
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
Molecular cancer therapeutics 2005;4(2):257-70.
2005: Rubén W Carón; Adly Yacoub; Xiaoyu Zhu; Clint Mitchell; Song Iy Han; Takehiko Sasazuki; Senji Shirasawa; Michael P Hagan; Steven Grant; Paul Dent
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Molecular cancer therapeutics 2005;4(2):243-55.
2004: Youwen Fang; Song Iy Han; Clint Mitchell; Seema Gupta; Elaine Studer; Steven Grant; Phillip B Hylemon; Paul Dent
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(4):961-71.
2004: Adly Yacoub; Clint Mitchell; Young Hong; Rahul V Gopalkrishnan; Zao-Zhong Su; Pankaj Gupta; Moria Sauane; Irina Lebedeva; David T Curiel; Parameshwar J Mahasreshti; Myrna R Rosenfeld; William C Broaddus; C David James; Steven Grant; Paul B Fisher; Paul Dent
MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
Cancer biology & therapy 2004;3(8):739-51.
2003: Adly Yacoub; Clint Mitchell; Andrea Lister; Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Carter Sigmon; Robert McKinstry; Viswanathan Ramakrishnan; Liang Qiao; William C Broaddus; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3272-81.
2003: Adly Yacoub; Clint Mitchell; Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Robert McKinstry; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.
Cancer biology & therapy 2003;2(4):347-53.
2003: Adly Yacoub; Clint Mitchell; Jessica Brannon; Elizabeth Rosenberg; Liang Qiao; Robert McKinstry; W Marston Linehan; Zao-shong Su; Devanand Sarkar; Irina Lebedeva; Kristoffer Valerie; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.
Molecular cancer therapeutics 2003;2(7):623-32.