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Thomas Mitchell

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Wiley A Schell; P Brian Smith; Barbara D Alexander; Daniel K Benjamin; J L Benton; D J Boles; Allen E Eckhardt; M D Johnson; Vamsee K Pamula; John R Perfect; M G Pollack; M Poore; J L Rouse; Thomas G Mitchell
Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.
Anastasia P Litvintseva; Thomas G Mitchell
Population genetic analyses reveal the African origin and strain variation of Cryptococcus neoformans var. grubii.
Guanggan Hu; Won Hee Jung; Rajeev Aurora; Tihana Bicanic; Jaehyuk Choi; Anastasia P Litvintseva; Iris Liu; Thomas G Mitchell; John R Perfect; Joyce Wang; James W Kronstad
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

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All Publications

2012: Wiley A Schell; P Brian Smith; Barbara D Alexander; Daniel K Benjamin; J L Benton; D J Boles; Allen E Eckhardt; M D Johnson; Vamsee K Pamula; John R Perfect; M G Pollack; M Poore; J L Rouse; Thomas G Mitchell
Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2012;31(9):2237-45.
2012: Anastasia P Litvintseva; Thomas G Mitchell
Population genetic analyses reveal the African origin and strain variation of Cryptococcus neoformans var. grubii.
PLoS pathogens 2012;8(2):e1002495.
2011: Guanggan Hu; Won Hee Jung; Rajeev Aurora; Tihana Bicanic; Jaehyuk Choi; Anastasia P Litvintseva; Iris Liu; Thomas G Mitchell; John R Perfect; Joyce Wang; James W Kronstad
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.
BMC genomics 2011;12():526.
2011: Anastasia P Litvintseva; Ignazio Carbone; Jenny Rossouw; Rameshwari Thakur; Nelesh P Govender; Thomas G Mitchell
Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa.
PloS one 2011;6(5):e19688.
2011: Kathleen J Miglia; Nelesh P Govender; Jenny Rossouw; Susan Taryn Meiring; Thomas G Mitchell
Analyses of pediatric isolates of Cryptococcus neoformans from South Africa.
Journal of clinical microbiology 2011;49(1):307-14.
2010: Elizabeth Wulff-Burchfield; Wiley A Schell; Allen E Eckhardt; Michael G Pollack; Zhishan Hua; Jeremy L Rouse; Vamsee K Pamula; Vijay Srinivasan; Jonathan L Benton; Barbara D Alexander; David A Wilfret; Monica Kraft; Charles B Cairns; John R Perfect; Thomas G Mitchell
Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens.
Diagnostic microbiology and infectious disease 2010;67(1):22-9.
2010: Zhishan Hua; Jeremy L Rouse; Allen E Eckhardt; Vijay Srinivasan; Vamsee K Pamula; Wiley A Schell; Jonathan L Benton; Thomas G Mitchell; Michael G Pollack
Multiplexed real-time polymerase chain reaction on a digital microfluidic platform.
Analytical chemistry 2010;82(6):2310-6.
2009: Anastasia P Litvintseva; Thomas G Mitchell
Most environmental isolates of Cryptococcus neoformans var. grubii (serotype A) are not lethal for mice.
Infection and immunity 2009;77(8):3188-95.
2009: Edmond J Byrnes; Robert J Bildfell; Sheryl A Frank; Thomas G Mitchell; Kieren Marr; Joseph Heitman
Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States.
The Journal of infectious diseases 2009;199(7):1081-6.
2009: Popchai Ngamskulrungroj; Felix Gilgado; Josiane Faganello; Anastasia P Litvintseva; Ana Lusia Leal; Kin Ming Tsui; Thomas G Mitchell; Marilene Henning Vainstein; Wieland Meyer
Genetic diversity of the Cryptococcus species complex suggests that Cryptococcus gattii deserves to have varieties.
PloS one 2009;4(6):e5862.
2009: Wieland Meyer; David M Aanensen; Teun Boekhout; Massimo Cogliati; Mara R Diaz; Maria Carmela Esposto; Matthew Fisher; Felix Gilgado; Ferry Hagen; Sirada Kaocharoen; Anastasia P Litvintseva; Thomas G Mitchell; Sitali P Simwami; Luciana Trilles; Maria Anna Viviani; June Kwon-Chung
Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2009;47(6):561-70.
2009: Xiaorong Lin; Sweta Patel; Anastasia P Litvintseva; Anna Floyd; Thomas G Mitchell; Joseph Heitman
Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating.
PLoS pathogens 2009;5(1):e1000283.
2007: Xiaorong Lin; Anastasia P Litvintseva; Kirsten Nielsen; Sweta Patel; Anna Floyd; Thomas G Mitchell; Joseph Heitman
alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness.
PLoS genetics 2007;3(10):1975-90.
2007: Anastasia P Litvintseva; Xiaorong Lin; Irka Templeton; Joseph Heitman; Thomas G Mitchell
Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa.
PLoS pathogens 2007;3(8):e114.
2006: Xiaorong Lin; Johnny C Huang; Thomas G Mitchell; Joseph Heitman
Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation.
PLoS genetics 2006;2(11):e187.
2006: Anastasia P Litvintseva; Rameshwari Thakur; Rytas Vilgalys; Thomas G Mitchell
Multilocus sequence typing reveals three genetic subpopulations of Cryptococcus neoformans var. grubii (serotype A), including a unique population in Botswana.
Genetics 2006;172(4):2223-38.
2005: Kirsten Nielsen; Robert E Marra; Ferry Hagen; Teun Boekhout; Thomas G Mitchell; Gary M Cox; Joseph Heitman
Interaction between genetic background and the mating-type locus in Cryptococcus neoformans virulence potential.
Genetics 2005;171(3):975-83.
2005: Harish C Gugnani; Thomas G Mitchell; Anastasia P Litvintseva; K B Lengeler; Joseph Heitman; A Kumar; Somansu Basu; Anubha Paliwal-Joshi
Isolation of Cryptococcus gattii and Cryptococcus neoformans var. grubii from the flowers and bark of Eucalyptus trees in India.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(6):565-9.
2005: Anastasia P Litvintseva; Rameshwari Thakur; L Barth Reller; Thomas G Mitchell
Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa.
The Journal of infectious diseases 2005;192(5):888-92.
2005: Kirsten Nielsen; Gary M Cox; Anastasia P Litvintseva; Eleftherios Mylonakis; Stephanie D Malliaris; Daniel K Benjamin; Steven S Giles; Thomas G Mitchell; Arturo Casadevall; John R Perfect; Joseph Heitman
Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection.
Infection and immunity 2005;73(8):4922-33.
2005: James A Fraser; Johnny C Huang; Read Pukkila-Worley; J Andrew Alspaugh; Thomas G Mitchell; Joseph Heitman
Chromosomal translocation and segmental duplication in Cryptococcus neoformans.
Eukaryotic cell 2005;4(2):401-6.
2005: Anastasia P Litvintseva; Lori Kestenbaum; Rytas Vilgalys; Thomas G Mitchell
Comparative analysis of environmental and clinical populations of Cryptococcus neoformans.
Journal of clinical microbiology 2005;43(2):556-64.
2004: Stephanie Diezmann; Cymon J Cox; Gabriele Schönian; Rytas Vilgalys; Thomas G Mitchell
Phylogeny and evolution of medical species of Candida and related taxa: a multigenic analysis.
Journal of clinical microbiology 2004;42(12):5624-35.
2004: Robert E Marra; Johnny C Huang; Eula Fung; Kirsten Nielsen; Joseph Heitman; Rytas Vilgalys; Thomas G Mitchell
A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans).
Genetics 2004;167(2):619-31.
2003: William J Steinbach; Thomas G Mitchell; Wiley A Schell; Ana Espinel-Ingroff; Richard Coico; THOMAS WALSH; John R Perfect
Status of medical mycology education.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2003;41(6):457-67.
2003: Anastasia P Litvintseva; Robert E Marra; Kirsten Nielsen; Joseph Heitman; Rytas Vilgalys; Thomas G Mitchell
Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa.
Eukaryotic cell 2003;2(6):1162-8.
2003: Jianping Xu; Thomas G Mitchell
Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformans.
Microbiology (Reading, England) 2003;149(Pt 8):2147-54.
2003: Jianping Xu; Thomas G Mitchell
Geographical differences in human oral yeast flora.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003;36(2):221-4.
2002: Guizhen Luo; Thomas G Mitchell
Rapid identification of pathogenic fungi directly from cultures by using multiplex PCR.
Journal of clinical microbiology 2002;40(8):2860-5.
2002: Jianping Xu; Guizhen Luo; Rytas Vilgalys; Mary E Brandt; Thomas G Mitchell
Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD.
Microbiology (Reading, England) 2002;148(Pt 1):203-12.
2001: Jianping Xu; Chiatogu Onyewu; H J Yoell; R Y Ali; Rytas Vilgalys; Thomas G Mitchell
Dynamic and heterogeneous mutations to fluconazole resistance in Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2001;45(2):420-7.
2000: A Forche; Jianping Xu; Rytas Vilgalys; Thomas G Mitchell
Development and characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms and other markers.
Fungal genetics and biology : FG & B 2000;31(3):189-203.
2000: Jianping Xu; Rytas Vilgalys; Thomas G Mitchell
Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans.
Molecular ecology 2000;9(10):1471-81.
2000: Thomas G Mitchell
Overview of basic medical mycology.
Otolaryngologic clinics of North America 2000;33(2):237-49.
2000: Jianping Xu; R Y Ali; D A Gregory; D Amick; S E Lambert; H J Yoell; Rytas Vilgalys; Thomas G Mitchell
Uniparental mitochondrial transmission in sexual crosses in Cryptococcus neoformans.
Current microbiology 2000;40(4):269-73.
2000: M Pinto de Andrade; Gabriele Schönian; A Forche; L Rosado; I Costa; M Müller; Wolfgang Presber; Thomas G Mitchell; HJ Tietz
Assessment of genetic relatedness of vaginal isolates of Candida albicans from different geographical origins.
International journal of medical microbiology : IJMM 2000;290(1):97-104.
2000: Jianping Xu; A R Ramos; Rytas Vilgalys; Thomas G Mitchell
Clonal and spontaneous origins of fluconazole resistance in Candida albicans.
Journal of clinical microbiology 2000;38(3):1214-20.
2000: Gabriele Schönian; A Forche; HJ Tietz; M Müller; Yvonne Gräser; Rytas Vilgalys; Thomas G Mitchell; Wolfgang Presber
[Genetic structure of geographically different populations of candida albicans].
Mycoses 2000;43 Suppl 2():51-6.
2000: Juan G McEwen; John W Taylor; D Carter; J Xu; M S Felipe; Rytas Vilgalys; Thomas G Mitchell; T Kasuga; T White; T Bui; C M Soares
Molecular typing of pathogenic fungi.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2000;38 Suppl 1():189-97.
1999: Jianping Xu; Cynthia M Boyd; Elizabeth Livingston; W Meyer; John F Madden; Thomas G Mitchell
Species and genotypic diversities and similarities of pathogenic yeasts colonizing women.
Journal of clinical microbiology 1999;37(12):3835-43.
1999: A Forche; Gabriele Schönian; Yvonne Gräser; Rytas Vilgalys; Thomas G Mitchell
Genetic structure of typical and atypical populations of Candida albicans from Africa.
Fungal genetics and biology : FG & B 1999;28(2):107-25.
1999: J Xu; Rytas Vilgalys; Thomas G Mitchell
Lack of genetic differentiation between two geographically diverse samples of Candida albicans isolated from patients infected with human immunodeficiency virus.
Journal of bacteriology 1999;181(4):1369-73.
1999: Jianping Xu; Thomas G Mitchell; Rytas Vilgalys
PCR-restriction fragment length polymorphism (RFLP) analyses reveal both extensive clonality and local genetic differences in Candida albicans.
Molecular ecology 1999;8(1):59-73.
1998: Jianping Xu; Rytas Vilgalys; Thomas G Mitchell
Colony size can be used to determine the MIC of fluconazole for pathogenic yeasts.
Journal of clinical microbiology 1998;36(8):2383-5.
1997: G Nicolas Latouche; Heide-Marie Daniel; Ok Cha Lee; Thomas G Mitchell; Tania C Sorrell; Wieland Meyer
Comparison of use of phenotypic and genotypic characteristics for identification of species of the anamorph genus Candida and related teleomorph yeast species.
Journal of clinical microbiology 1997;35(12):3171-80.
1997: R K Li; Thomas G Mitchell
Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1997;35(5):327-34.
1997: Wieland Meyer; G Nicolas Latouche; Heide-Marie Daniel; M Thanos; Thomas G Mitchell; D Yarrow; Gabriele Schönian; Tania C Sorrell
Identification of pathogenic yeasts of the imperfect genus Candida by polymerase chain reaction fingerprinting.
Electrophoresis 1997;18(9):1548-59.
1996: Yvonne Gräser; M Volovsek; J Arrington; Gabriele Schönian; Wolfgang Presber; Thomas G Mitchell; Rytas Vilgalys
Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12473-7.
1996: M Thanos; G Schonian; Wieland Meyer; C Schweynoch; Y Graser; Thomas G Mitchell; Wolfgang Presber; HJ Tietz
Rapid identification of Candida species by DNA fingerprinting with PCR.
Journal of clinical microbiology 1996;34(3):615-21.
1995: Thomas G Mitchell; John R Perfect
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.
Clinical microbiology reviews 1995;8(4):515-48.
1995: W Meyer; Thomas G Mitchell
Polymerase chain reaction fingerprinting in fungi using single primers specific to minisatellites and simple repetitive DNA sequences: strain variation in Cryptococcus neoformans.
Electrophoresis 1995;16(9):1648-56.
1995: J W Spatafora; Thomas G Mitchell; Rytas Vilgalys
Analysis of genes coding for small-subunit rRNA sequences in studying phylogenetics of dematiaceous fungal pathogens.
Journal of clinical microbiology 1995;33(5):1322-6.
1994: Thomas G Mitchell; E Z Freedman; T J White; J W Taylor
Unique oligonucleotide primers in PCR for identification of Cryptococcus neoformans.
Journal of clinical microbiology 1994;32(1):253-5.
1994: Thomas G Mitchell; R L Sandin; B H Bowman; W Meyer; William G Merz
Molecular mycology: DNA probes and applications of PCR technology.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1994;32 Suppl 1():351-66.
1993: W Meyer; Thomas G Mitchell; E Z Freedman; Rytas Vilgalys
Hybridization probes for conventional DNA fingerprinting used as single primers in the polymerase chain reaction to distinguish strains of Cryptococcus neoformans.
Journal of clinical microbiology 1993;31(9):2274-80.
1993: Gabriele Schönian; O Meusel; HJ Tietz; W Meyer; Yvonne Gräser; I Tausch; Wolfgang Presber; Thomas G Mitchell
Identification of clinical strains of Candida albicans by DNA fingerprinting with the polymerase chain reaction.
Mycoses 1993;36(5-6):171-9.
1993: W Meyer; E Lieckfeldt; Katrin Kuhls; E Z Freedman; Thomas Börner; Thomas G Mitchell
DNA- and PCR-fingerprinting in fungi.
EXS 1993;67():311-20.
1992: Thomas G Mitchell; T J White; J W Taylor
Comparison of 5.8S ribosomal DNA sequences among the basidiomycetous yeast genera Cystofilobasidium, Filobasidium and Filobasidiella.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1992;30(3):207-18.
1991: M F Miller; Thomas G Mitchell
Killing of Cryptococcus neoformans strains by human neutrophils and monocytes.
Infection and immunity 1991;59(1):24-8.
1990: M F Miller; Thomas G Mitchell; Walter J Storkus; Jeffrey R Dawson
Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody.
Infection and immunity 1990;58(3):639-45.
1989: B Bolaños; Thomas G Mitchell
Phagocytosis and killing of Cryptococcus neoformans by rat alveolar macrophages in the absence of serum.
Journal of leukocyte biology 1989;46(6):521-8.
1989: J M Small; Thomas G Mitchell
Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A.
Infection and immunity 1989;57(12):3751-6.
1989: B Bolaños; Thomas G Mitchell
Killing of Cryptococcus neoformans by rat alveolar macrophages.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1989;27(4):219-28.
1989: B Bolaños; Thomas G Mitchell
Phagocytosis of Cryptococcus neoformans by rat alveolar macrophages.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1989;27(4):203-17.
1988: B J Ferguson; Thomas G Mitchell; R Moon; Enrico M Camporesi; J Farmer
Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis.
Reviews of infectious diseases 1988;10(3):551-9.
1986: J M Small; Thomas G Mitchell
Binding of purified and radioiodinated capsular polysaccharides from Cryptococcus neoformans serotype A strains to capsule-free mutants.
Infection and immunity 1986;54(3):742-50.
1986: J M Small; Thomas G Mitchell; R W Wheat
Strain variation in composition and molecular size of the capsular polysaccharide of Cryptococcus neoformans serotype A.
Infection and immunity 1986;54(3):735-41.