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John Mitcheson

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TOP 3
Frederick W Muskett; John S Mitcheson
Resonance assignment and secondary structure prediction of the N-terminal domain of hERG (Kv11.1).
Frederick W Muskett; Samrat Thouta; Steven J Thomson; Alexander Bowen; Phillip J Stansfeld; John S Mitcheson
Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.
Matthew Perry; Michael Sanguinetti; John S Mitcheson
Revealing the structural basis of action of hERG potassium channel activators and blockers.

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All Publications

2011: Frederick W Muskett; John S Mitcheson
Resonance assignment and secondary structure prediction of the N-terminal domain of hERG (Kv11.1).
Biomolecular NMR assignments 2011;5(1):15-7.
2011: Frederick W Muskett; Samrat Thouta; Steven J Thomson; Alexander Bowen; Phillip J Stansfeld; John S Mitcheson
Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.
The Journal of biological chemistry 2011;286(8):6184-91.
2010: Matthew Perry; Michael Sanguinetti; John S Mitcheson
Revealing the structural basis of action of hERG potassium channel activators and blockers.
The Journal of physiology 2010;588(Pt 17):3157-67.
2008: Phillip J Stansfeld; Alessandro Grottesi; Zara A Sands; Mark S P Sansom; Peter Gedeck; Martin Gosling; Brian Cox; Peter R Stanfield; John S Mitcheson; Michael J Sutcliffe
Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.
Biochemistry 2008;47(28):7414-22.
2008: John S Mitcheson
hERG potassium channels and the structural basis of drug-induced arrhythmias.
Chemical research in toxicology 2008;21(5):1005-10.
2007: Rachael M Hardman; Phillip J Stansfeld; Sarah Dalibalta; Michael J Sutcliffe; John S Mitcheson
Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.
The Journal of biological chemistry 2007;282(44):31972-81.
2007: Phillip J Stansfeld; Peter Gedeck; Martin Gosling; Brian Cox; John S Mitcheson; Michael J Sutcliffe
Drug block of the hERG potassium channel: insight from modeling.
Proteins 2007;68(2):568-80.
2007: S L Cockerill; Andrew B Tobin; Ignacio Torrecilla; Gary B Willars; Nicholas B Standen; John S Mitcheson
Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits.
The Journal of physiology 2007;581(Pt 2):479-93.
2006: Jules C Hancox; John S Mitcheson
Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology.
British journal of pharmacology 2006;149(5):457-9.
2006: Kaichiro Kamiya; Ryoko Niwa; John S Mitcheson; Michael C Sanguinetti
Molecular determinants of HERG channel block.
Molecular pharmacology 2006;69(5):1709-16.
2006: Phillip J Stansfeld; Michael J Sutcliffe; John S Mitcheson
Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.
Expert opinion on drug metabolism & toxicology 2006;2(1):81-94.
2006: Matthew Perry; Phillip J Stansfeld; Joanne L Leaney; Claire Wood; Marcel J de Groot; Derek Leishman; Michael J Sutcliffe; John S Mitcheson
Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.
Molecular pharmacology 2006;69(2):509-19.
2006: S L Cockerill; John S Mitcheson
Direct block of human ether-a-go-go-related gene potassium channels by caffeine.
The Journal of pharmacology and experimental therapeutics 2006;316(2):860-8.
2005: Michael C Sanguinetti; John S Mitcheson
Predicting drug-hERG channel interactions that cause acquired long QT syndrome.
Trends in pharmacological sciences 2005;26(3):119-24.
2005: Michael C Sanguinetti; Jun Chen; David Fernandez; Kaichiro Kamiya; John S Mitcheson; Jose A Sanchez-Chapula
Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.
Novartis Foundation symposium 2005;266():159-66; discussion 166-70.
2005: John S Mitcheson; Matthew Perry; Phillip J Stansfeld; Michael C Sanguinetti; Harry Witchel; Jules Hancox
Structural determinants for high-affinity block of hERG potassium channels.
Novartis Foundation symposium 2005;266():136-50; discussion 150-8.
2004: Christina Davie; Jean Pierre-Valentin; Chris Pollard; Nick Standen; John S Mitcheson; Paul Alexander; Bob Thong
Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
Journal of cardiovascular electrophysiology 2004;15(11):1302-9.
2004: Harry J Witchel; Christopher E Dempsey; Richard B Sessions; Matthew Perry; James T Milnes; Jules C Hancox; John S Mitcheson
The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.
Molecular pharmacology 2004;66(5):1201-12.
2004: Matthew Perry; Marcel J de Groot; Ray Helliwell; Derek Leishman; Martin Tristani-Firouzi; Michael C Sanguinetti; John S Mitcheson
Structural determinants of HERG channel block by clofilium and ibutilide.
Molecular pharmacology 2004;66(2):240-9.
2003: John S Mitcheson; Matthew D Perry
Molecular determinants of high-affinity drug binding to HERG channels.
Current opinion in drug discovery & development 2003;6(5):667-74.
2003: John S Mitcheson
Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamine.
British journal of pharmacology 2003;139(5):883-4.
2002: Vijay K Pabbathi; Yin Hua Zhang; John S Mitcheson; Annabel K Hinde; L Perchenet; Lesley A Arberry; AJ Levi; Jules C Hancox
Comparison of Na(+)/Ca(2+) exchanger current and of its response to isoproterenol between acutely isolated and short-term cultured adult ventricular myocytes.
Biochemical and biophysical research communications 2002;297(2):302-8.
2002: Harry J Witchel; James T Milnes; John S Mitcheson; Jules C Hancox
Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes.
Journal of pharmacological and toxicological methods 2002;48(2):65-80.
2001: Jun Chen; John S Mitcheson; Martin Tristani-Firouzi; M Lin; Michael C Sanguinetti
The S4-S5 linker couples voltage sensing and activation of pacemaker channels.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11277-82.
2001: Kaichiro Kamiya; John S Mitcheson; Kenji Yasui; Itsuo Kodama; Michael C Sanguinetti
Open channel block of HERG K(+) channels by vesnarinone.
Molecular pharmacology 2001;60(2):244-53.
2001: Martin Tristani-Firouzi; Jun Chen; John S Mitcheson; Michael C Sanguinetti
Molecular biology of K(+) channels and their role in cardiac arrhythmias.
The American journal of medicine 2001;110(1):50-9.
2000: Jun Chen; John S Mitcheson; M Lin; Michael C Sanguinetti
Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel.
The Journal of biological chemistry 2000;275(46):36465-71.
2000: John S Mitcheson; Jun Chen; M Lin; Chris Culberson; Michael C Sanguinetti
A structural basis for drug-induced long QT syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12329-33.
2000: John S Mitcheson; Jun Chen; Michael C Sanguinetti
Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.
The Journal of general physiology 2000;115(3):229-40.
1999: John S Mitcheson; Jules C Hancox
An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes.
Pflügers Archiv : European journal of physiology 1999;438(6):843-50.
1999: John S Mitcheson; Jules C Hancox
Characteristics of a transient outward current (sensitive to 4-aminopyridine) in Ca2+-tolerant myocytes isolated from the rabbit atrioventricular node.
Pflügers Archiv : European journal of physiology 1999;438(1):68-78.
1999: John S Mitcheson; Michael C Sanguinetti
Biophysical properties and molecular basis of cardiac rapid and slow delayed rectifier potassium channels.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1999;9(4-5):201-16.
1998: John S Mitcheson; Jules C Hancox; AJ Levi
Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties.
Cardiovascular research 1998;39(2):280-300.
1997: Jules C Hancox; John S Mitcheson
Ion channel and exchange currents in single myocytes isolated from the rabbit atrioventricular node.
The Canadian journal of cardiology 1997;13(12):1175-82.
1997: John S Mitcheson; Jules C Hancox
Modulation by mexiletine of action potentials, L-type Ca current and delayed rectifier K current recorded from isolated rabbit atrioventricular nodal myocytes.
Pflügers Archiv : European journal of physiology 1997;434(6):855-8.
1997: John S Mitcheson; Jules C Hancox; AJ Levi
Cultured adult rabbit myocytes: effect of adding supplements to the medium, and response to isoprenaline.
Journal of cardiovascular electrophysiology 1997;8(9):1020-30.
1997: AJ Levi; GR Dalton; Jules C Hancox; John S Mitcheson; J Issberner; J A Bates; SJ Evans; Frank Christopher Howarth; IA Hobai; JV Jones
Role of intracellular sodium overload in the genesis of cardiac arrhythmias.
Journal of cardiovascular electrophysiology 1997;8(6):700-21.
1997: Jules C Hancox; John S Mitcheson
Inhibition of L-type calcium current by propafenone in single myocytes isolated from the rabbit atrioventricular node.
British journal of pharmacology 1997;121(1):7-14.
1997: John S Mitcheson; Jules C Hancox; AJ Levi
Voltage dependence of the Fura-2 transient in rabbit left atrial myocytes at 37 degrees C.
Pflügers Archiv : European journal of physiology 1997;433(6):817-26.
1996: John S Mitcheson; Jules C Hancox; AJ Levi
Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture.
Pflügers Archiv : European journal of physiology 1996;431(6):814-27.
1996: AJ Levi; John S Mitcheson; Jules C Hancox
The effect of internal sodium and caesium on phasic contraction of patch-clamped rabbit ventricular myocytes.
The Journal of physiology 1996;492 ( Pt 1)():1-19.