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Sankar Mitra

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Susan Tsutakawa; Andrew S Arvai; Richard P Cunningham; Kenneth A Frankel; Kenichi Hitomi; David J Hosfield; Ivaylo N Ivanov; Tadahide Izumi; Buddhadev Maiti; Anil K Mantha; Sankar Mitra; Clifford D Mol; Mike E Pique; David S Shin; Bartosz Szczesny; John A Tainer
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
Julie Della-Maria; Tom Ellenberger; Muralidhar L Hegde; Yoshihiro Matsumoto; Daniel R McNeill; Sankar Mitra; Miaw-Sheue Tsai; David M Wilson; Alan E Tomkinson
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.
Muralidhar Hegde; Pavana Hegde; Srijita Banerjee; Larry J Bellot; Istvan Boldogh; Tapas K Hazra; Sankar Mitra
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction.

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All Publications

2013: Susan Tsutakawa; Andrew S Arvai; Richard P Cunningham; Kenneth A Frankel; Kenichi Hitomi; David J Hosfield; Ivaylo N Ivanov; Tadahide Izumi; Buddhadev Maiti; Anil K Mantha; Sankar Mitra; Clifford D Mol; Mike E Pique; David S Shin; Bartosz Szczesny; John A Tainer
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
The Journal of biological chemistry 2013;288(12):8445-55.
2012: Julie Della-Maria; Tom Ellenberger; Muralidhar L Hegde; Yoshihiro Matsumoto; Daniel R McNeill; Sankar Mitra; Miaw-Sheue Tsai; David M Wilson; Alan E Tomkinson
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.
The Journal of biological chemistry 2012;287(46):39233-44.
2012: Muralidhar Hegde; Pavana Hegde; Srijita Banerjee; Larry J Bellot; Istvan Boldogh; Tapas K Hazra; Sankar Mitra
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction.
The Journal of biological chemistry 2012;287(41):34202-11.
2012: Anil K Mantha; Regino J Perez-Polo; Giulio Taglialatela; Monisha Dhiman; Sankar Mitra
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
Journal of neuroscience research 2012;90(6):1230-9.
2012: Shiladitya Sengupta; Ranajoy Chattopadhyay; Anil K Mantha; Sankar Mitra; Kishor K Bhakat
Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex.
Journal of hypertension 2012;30(5):917-25.
2012: Muralidhar Hegde; Anil K Mantha; Sankar Mitra; Kishor K Bhakat; Tapas K Hazra; Bartosz Szczesny
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.
Mechanisms of ageing and development 2012;133(4):157-68.
2012: Muralidhar L Hegde; Tadahide Izumi; Sankar Mitra
Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.
Progress in molecular biology and translational science 2012;110():123-53.
2011: Sankar Mitra
Does evening sun increase the risk of skin cancer?
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):18857-8.
2011: Anne W Tann; Bennett Van Houten; Istvan Boldogh; Gregor Meiss; Sankar Mitra; Wei Qian; Bartosz Szczesny
Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair.
The Journal of biological chemistry 2011;286(37):31975-83.
2011: S Sengupta; A K Mantha; Sankar Mitra; Kishor K Bhakat
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1.
Oncogene 2011;30(4):482-93.
2011: Muralidhar Hegde; Pavana Hegde; K S Rao; Sankar Mitra
Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword.
Journal of Alzheimer's disease : JAD 2011;24 Suppl 2():183-98.
2010: Muralidhar Hegde; Tapas K Hazra; Sankar Mitra
Functions of disordered regions in mammalian early base excision repair proteins.
Cellular and molecular life sciences : CMLS 2010;67(21):3573-87.
2010: Corey A Theriot; Muralidhar Hegde; Tapas K Hazra; Sankar Mitra
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures.
DNA repair 2010;9(6):643-52.
2010: Bartosz Szczesny; Anne W Tann; Sankar Mitra
Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury.
Mechanisms of ageing and development 2010;131(5):330-7.
2009: Dora Bocangel; Shiladitya Sengupta; Sankar Mitra; Kishor K Bhakat
p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.
Anticancer research 2009;29(10):3741-50.
2009: Asima Bhattacharyya; Ranajoy Chattopadhyay; Brent R Burnette; Janet V Cross; Sankar Mitra; Peter B Ernst; Kishor K Bhakat; Sheila E Crowe
Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis.
Gastroenterology 2009;136(7):2258-69.
2009: Ann M O'Hara; Asima Bhattacharyya; Jie Bai; Randy C Mifflin; Peter B Ernst; Sankar Mitra; Sheila E Crowe
Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1.
Cytokine 2009;46(3):359-69.
2009: Kishor K Bhakat; Anil K Mantha; Sankar Mitra
Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.
Antioxidants & redox signaling 2009;11(3):621-38.
2008: Ranajoy Chattopadhyay; Soumita Das; Amit K Maiti; Istvan Boldogh; Jingwu Xie; Tapas K Hazra; Kimitoshi Kohno; Sankar Mitra; Kishor K Bhakat
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.
Molecular and cellular biology 2008;28(23):7066-80.
2008: Muralidhar Hegde; Corey A Theriot; Aditi Das; Pavana Hegde; Zhigang Guo; Ronald K Gary; Tapas K Hazra; Binghui Shen; Sankar Mitra
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.
The Journal of biological chemistry 2008;283(40):27028-37.
2008: Bartosz Szczesny; Anne W Tann; Matthew J Longley; William C Copeland; Sankar Mitra
Long patch base excision repair in mammalian mitochondrial genomes.
The Journal of biological chemistry 2008;283(39):26349-56.
2008: Amit K Maiti; Istvan Boldogh; Heidi Spratt; Sankar Mitra; Tapas K Hazra
Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme.
DNA repair 2008;7(8):1213-20.
2008: Anil K Mantha; Numan Oezguen; Kishor K Bhakat; Tadahide Izumi; Werner Braun; Sankar Mitra
Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.
Journal of molecular biology 2008;379(1):28-37.
2008: Amira Zaky; Carlos Busso; Tadahide Izumi; Ranajoy Chattopadhyay; Ahmad Bassiouny; Sankar Mitra; Kishor K Bhakat
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.
Nucleic acids research 2008;36(5):1555-66.
2008: Varatharasa Thiviyanathan; Anoma Somasunderam; David Volk; Tapas K Hazra; Sankar Mitra; David Gorenstein
Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil.
Biochemical and biophysical research communications 2008;366(3):752-7.
2008: Hong Dou; Corey A Theriot; Aditi Das; Muralidhar Hegde; Yoshihiro Matsumoto; Istvan Boldogh; Tapas K Hazra; Kishor K Bhakat; Sankar Mitra
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.
The Journal of biological chemistry 2008;283(6):3130-40.
2008: Muralidhar Hegde; Tapas K Hazra; Sankar Mitra
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells.
Cell research 2008;18(1):27-47.
2007: Aditi Das; Istvan Boldogh; Jae Wan Lee; Jeanine A Harrigan; Muralidhar Hegde; Jason Piotrowski; Nadja C de Souza-Pinto; William Ramos; Marc M Greenberg; Tapas K Hazra; Sankar Mitra; Vilhelm A Bohr
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1.
The Journal of biological chemistry 2007;282(36):26591-602.
2007: Sankar Mitra
MGMT: a personal perspective.
DNA repair 2007;6(8):1064-70.
2007: Sankar Mitra; Tadahide Izumi; Istvan Boldogh; Kishor K Bhakat; Ranajoy Chattopadhyay; Bartosz Szczesny
Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.
DNA repair 2007;6(4):461-9.
2007: Xin Guan; Haibo Bai; Guoli Shi; Corey A Theriot; Tapas K Hazra; Sankar Mitra; A-Lien Lu-Chang
The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase.
Nucleic acids research 2007;35(8):2463-72.
2006: Aditi Das; Lee Wiederhold; John B Leppard; Padmini Kedar; Rajendra Prasad; Huxian Wang; Istvan Boldogh; Feridoun Karimi-Busheri; Michael Weinfeld; Alan E Tomkinson; Samuel H Wilson; Sankar Mitra; Tapas K Hazra
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells.
DNA repair 2006;5(12):1439-48.
2006: Ann M O'Hara; Asima Bhattacharyya; Randy C Mifflin; Michael Smith, Jr.; Kieran A Ryan; Kevin G-E Scott; Makoto Naganuma; Antonella Casola; Tadahide Izumi; Sankar Mitra; Peter B Ernst; Sheila E Crowe
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7990-9.
2006: Attila Bacsi; Mitchell Woodberry; William R Widger; John Papaconstantinou; Sankar Mitra; Johnny W Peterson; Istvan Boldogh
Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells.
Mitochondrion 2006;6(5):235-44.
2006: Kishor K Bhakat; Sanath K Mokkapati; Istvan Boldogh; Tapas K Hazra; Sankar Mitra
Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.
Molecular and cellular biology 2006;26(5):1654-65.
2006: Tapas K Hazra; Sankar Mitra
Purification and characterization of NEIL1 and NEIL2, members of a distinct family of mammalian DNA glycosylases for repair of oxidized bases.
Methods in enzymology 2006;408():33-48.
2006: Ranajoy Chattopadhyay; Lee Wiederhold; Bartosz Szczesny; Istvan Boldogh; Tapas K Hazra; Tadahide Izumi; Sankar Mitra
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.
Nucleic acids research 2006;34(7):2067-76.
2005: Aditi Das; Tapas K Hazra; Istvan Boldogh; Sankar Mitra; Kishor K Bhakat
Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species.
The Journal of biological chemistry 2005;280(42):35272-80.
2005: Bartosz Szczesny; Sankar Mitra
Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver.
Mechanisms of ageing and development 2005;126(10):1071-8.
2005: Istvan Boldogh; Attila Bacsi; Barun K Choudhury; Nilesh Dharajiya; Rafeul Alam; Tapas K Hazra; Sankar Mitra; Randall M Goldblum; Sanjiv Sur
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation.
The Journal of clinical investigation 2005;115(8):2169-79.
2005: Tadahide Izumi; David B Brown; C V Naidu; Kishor K Bhakat; Mark A Macinnes; Hiroshi Saito; David J Chen; Sankar Mitra
Two essential but distinct functions of the mammalian abasic endonuclease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5739-43.
2005: Elias Jackson; Corey A Theriot; Ranajoy Chattopadhyay; Sankar Mitra; Tadahide Izumi
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).
Nucleic acids research 2005;33(10):3303-12.
2004: Aditi Das; Lavanya Rajagopalan; Venkatarajan S Mathura; Samuel J Rigby; Sankar Mitra; Tapas K Hazra
Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein.
The Journal of biological chemistry 2004;279(45):47132-8.
2004: Bartosz Szczesny; Kishor K Bhakat; Sankar Mitra; Istvan Boldogh
Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution.
Mechanisms of ageing and development 2004;125(10-11):755-65.
2004: Sanath K Mokkapati; Lee Wiederhold; Tapas K Hazra; Sankar Mitra
Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases.
Biochemistry 2004;43(36):11596-604.
2004: Song-Ze Ding; Ann M O'Hara; Timothy L Denning; Bernadette Dirden-Kramer; Randy C Mifflin; Victor E Reyes; Kieran A Ryan; Susan N Elliott; Tadahide Izumi; Istvan Boldogh; Sankar Mitra; Peter B Ernst; Sheila E Crowe
Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells.
Gastroenterology 2004;127(3):845-58.
2004: Lee Wiederhold; John B Leppard; Padmini Kedar; Feridoun Karimi-Busheri; Aghdass Rasouli-Nia; Michael Weinfeld; Alan E Tomkinson; Tadahide Izumi; Rajendra Prasad; Samuel H Wilson; Sankar Mitra; Tapas K Hazra
AP endonuclease-independent DNA base excision repair in human cells.
Molecular cell 2004;15(2):209-20.
2004: Kishor K Bhakat; Tapas K Hazra; Sankar Mitra
Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.
Nucleic acids research 2004;32(10):3033-9.
2004: Balazs Ribar; Tadahide Izumi; Sankar Mitra
The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe.
Nucleic acids research 2004;32(1):115-26.
2003: Hong Dou; Sankar Mitra; Tapas K Hazra
Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.
The Journal of biological chemistry 2003;278(50):49679-84.
2003: Kishor K Bhakat; Tadahide Izumi; Suk-Hoon Yang; Tapas K Hazra; Sankar Mitra
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
The EMBO journal 2003;22(23):6299-309.
2003: Istvan Boldogh; Gargi Roy; Myung Soog Lee; Attila Bacsi; Tapas K Hazra; Kishor K Bhakat; Gokul C Das; Sankar Mitra
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.
Toxicology 2003;193(1-2):137-52.
2003: Tadahide Izumi; Lee Wiederhold; Gargi Roy; Rabindra Roy; Arun Jaiswal; Kishor K Bhakat; Sankar Mitra; Tapas K Hazra
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage.
Toxicology 2003;193(1-2):43-65.
2003: Bartosz Szczesny; Tapas K Hazra; John Papaconstantinou; Sankar Mitra; Istvan Boldogh
Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10670-5.
2003: Kishor K Bhakat; Sankar Mitra
CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration.
Carcinogenesis 2003;24(8):1337-45.
2003: Tapas K Hazra; Tadahide Izumi; Yoke W Kow; Sankar Mitra
The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications.
Carcinogenesis 2003;24(2):155-7.
2003: Varatharasa Thiviyanathan; Anoma Somasunderam; Tapas K Hazra; Sankar Mitra; David Gorenstein
Solution structure of a DNA duplex containing 8-hydroxy-2'-deoxyguanosine opposite deoxyguanosine.
Journal of molecular biology 2003;325(3):433-42.
2003: Kishor K Bhakat; Suk Hoon Yang; Sankar Mitra
Acetylation of human AP-endonuclease 1, a critical enzyme in DNA repair and transcription regulation.
Methods in enzymology 2003;371():292-300.
2002: Tapas K Hazra; Yoke W Kow; Zafer Hatahet; Barry Imhoff; Istvan Boldogh; Sanath K Mokkapati; Sankar Mitra; Tadahide Izumi
Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.
The Journal of biological chemistry 2002;277(34):30417-20.
2002: Tapan Biswas; Lawrence J Clos; John SantaLucia; Sankar Mitra; Rabindra Roy
Binding of specific DNA base-pair mismatches by N-methylpurine-DNA glycosylase and its implication in initial damage recognition.
Journal of molecular biology 2002;320(3):503-13.
2002: Sankar Mitra; Tadahide Izumi; Istvan Boldogh; Kishor K Bhakat; Jeff W Hill; Tapas K Hazra
Choreography of oxidative damage repair in mammalian genomes.
Free radical biology & medicine 2002;33(1):15-28.
2002: Tapas K Hazra; Tadahide Izumi; Istvan Boldogh; Barry Imhoff; Yoke W Kow; Pawel Jaruga; Miral Dizdaroglu; Sankar Mitra
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3523-8.
2002: David Kuninger; Tadahide Izumi; John Papaconstantinou; Sankar Mitra
Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.
Nucleic acids research 2002;30(3):823-9.
2001: Tapas K Hazra; James G Muller; Raymond C Manuel; Cynthia J Burrows; R Stephen Lloyd; Sankar Mitra
Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli.
Nucleic acids research 2001;29(9):1967-74.
2001: Jeff W Hill; Tapas K Hazra; Tadahide Izumi; Sankar Mitra
Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair.
Nucleic acids research 2001;29(2):430-8.
2001: Tapas K Hazra; Jeff W Hill; Tadahide Izumi; Sankar Mitra
Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.
Progress in nucleic acid research and molecular biology 2001;68():193-205.
2001: Sankar Mitra
DNA glycosylases: specificity and mechanisms.
Progress in nucleic acid research and molecular biology 2001;68():189-92.
2000: Kishor K Bhakat; Sankar Mitra
Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300.
The Journal of biological chemistry 2000;275(44):34197-204.
2000: Tapas K Hazra; Tadahide Izumi; R Venkataraman; Yoke W Kow; Miral Dizdaroglu; Sankar Mitra
Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII.
The Journal of biological chemistry 2000;275(36):27762-7.
2000: Tadahide Izumi; Tapas K Hazra; Istvan Boldogh; Alan E Tomkinson; M S Park; S Ikeda; Sankar Mitra
Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species.
Carcinogenesis 2000;21(7):1329-34.
2000: G Wang; Tapas K Hazra; Sankar Mitra; Heung-Man Lee; Ella W Englander
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Nucleic acids research 2000;28(10):2135-40.
2000: Rabindra Roy; Tapan Biswas; J Ching Lee; Sankar Mitra
Mutation of a unique aspartate residue abolishes the catalytic activity but not substrate binding of the mouse N-methylpurine-DNA glycosylase (MPG).
The Journal of biological chemistry 2000;275(6):4278-82.
2000: Gargi Roy; Julie K Horton; R Roy; Timothy L Denning; Sankar Mitra; Istvan Boldogh
Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro- and anti-apoptotic proteins.
Oncogene 2000;19(1):141-50.
1999: Tadahide Izumi; J Malecki; M A Chaudhry; Michael Weinfeld; J H Hill; J Ching Lee; Sankar Mitra
Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease.
Journal of molecular biology 1999;287(1):47-57.
1999: Tapan Biswas; chilakamarti ramana; G Srinivasan; Istvan Boldogh; Tapas K Hazra; Z Chen; K Tano; E Brad Thompson; Sankar Mitra
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone.
Oncogene 1999;18(2):525-32.
1998: Michael Edwards; Kent Thomas; Harriett C Rea; J Wei; Michael J Quast; Tadahide Izumi; Sankar Mitra; J Regino Perez-Polo
APE/Ref-1 responses to ischemia in rat brain.
Neuroreport 1998;9(18):4015-8.
1998: Michael Edwards; David K Rassin; Tadahide Izumi; Sankar Mitra; J Regino Perez-Polo
APE/Ref-1 responses to oxidative stress in aged rats.
Journal of neuroscience research 1998;54(5):635-8.
1998: Tapas K Hazra; Tadahide Izumi; L Maidt; R A Floyd; Sankar Mitra
The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.
Nucleic acids research 1998;26(22):5116-22.
1998: Robert E Johnson; Carlos A Torres-Ramos; Tadahide Izumi; Sankar Mitra; Satya Prakash; Louise Prakash
Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.
Genes & development 1998;12(19):3137-43.
1998: Istvan Boldogh; chilakamarti ramana; Z Chen; Tapan Biswas; Tapas K Hazra; S Grösch; T Grombacher; Sankar Mitra; B Kaina
Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling.
Cancer research 1998;58(17):3950-6.
1998: S Ikeda; Tapan Biswas; Rabindra Roy; Tadahide Izumi; Istvan Boldogh; Alexander Kurosky; A H Sarker; S Seki; Sankar Mitra
Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue.
The Journal of biological chemistry 1998;273(34):21585-93.
1998: chilakamarti ramana; Istvan Boldogh; Tadahide Izumi; Sankar Mitra
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5061-6.
1998: Tadahide Izumi; Sankar Mitra
Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity.
Carcinogenesis 1998;19(3):525-7.
1998: D Bhattacharyya; T K Hazra; W D Behnke; P L Chong; A Kurosky; J C Lee; Sankar Mitra
Reversible folding of Ada protein (O6-methylguanine-DNA methyltransferase) of Escherichia coli.
Biochemistry 1998;37(6):1722-30.
1998: Rabindra Roy; Tapan Biswas; Tapas K Hazra; G Roy; D T Grabowski; Tadahide Izumi; G Srinivasan; Sankar Mitra
Specific interaction of wild-type and truncated mouse N-methylpurine-DNA glycosylase with ethenoadenine-containing DNA.
Biochemistry 1998;37(2):580-9.
1997: Tadahide Izumi; M Tatsuka; K Tano; M Asano; Sankar Mitra
Molecular cloning and characterization of the promoter of the human N-methylpurine-DNA glycosylase (MPG) gene.
Carcinogenesis 1997;18(9):1837-9.
1997: Sankar Mitra; Tapas K Hazra; Rabindra Roy; S Ikeda; Tapan Biswas; J Lock; Istvan Boldogh; Tadahide Izumi
Complexities of DNA base excision repair in mammalian cells.
Molecules and cells 1997;7(3):305-12.
1997: K Tano; W C Dunn; Firouz Darroudi; S Shiota; R J Preston; Adayapalam T Natarajan; Sankar Mitra
Amplification of the DNA repair gene O6-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line.
The Journal of biological chemistry 1997;272(20):13250-4.
1997: Tapas K Hazra; Rabindra Roy; Tapan Biswas; D T Grabowski; A E Pegg; Sankar Mitra
Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.
Biochemistry 1997;36(19):5769-76.
1997: G Roy; Rabindra Roy; Sankar Mitra
Quantitative reverse transcriptase polymerase chain reaction for measuring the N-methylpurine-DNA glycosylase mRNA level in rodent cells.
Analytical biochemistry 1997;246(1):45-51.
1996: Tadahide Izumi; W D Henner; Sankar Mitra
Negative regulation of the major human AP-endonuclease, a multifunctional protein.
Biochemistry 1996;35(47):14679-83.
1996: T Grombacher; Sankar Mitra; Bernd Kaina
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes.
Carcinogenesis 1996;17(11):2329-36.
1996: Rabindra Roy; S J Kennel; Sankar Mitra
Distinct substrate preference of human and mouse N-methylpurine-DNA glycosylases.
Carcinogenesis 1996;17(10):2177-82.
1996: Rabindra Roy; A Kumar; J Ching Lee; Sankar Mitra
The domains of mammalian base excision repair enzyme N-methylpurine-DNA glycosylase. Interaction, conformational change, and role in DNA binding and damage recognition.
The Journal of biological chemistry 1996;271(39):23690-7.
1995: Rabindra Roy; S Shiota; S J Kennel; R Raha; M von Wronski; Thomas P Brent; Sankar Mitra
A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases.
Carcinogenesis 1995;16(2):405-11.
1995: M Tatsuka; G C Ibeanu; Tadahide Izumi; S Narayan; chilakamarti ramana; N K Kim; W Kang; G Roy; Sankar Mitra
Structural organization of the mouse DNA repair gene, N-methylpurine-DNA glycosylase.
DNA and cell biology 1995;14(1):37-45.
1994: Rabindra Roy; C Brooks; Sankar Mitra
Purification and biochemical characterization of recombinant N-methylpurine-DNA glycosylase of the mouse.
Biochemistry 1994;33(50):15131-40.
1993: Sankar Mitra; Bernd Kaina
Regulation of repair of alkylation damage in mammalian genomes.
Progress in nucleic acid research and molecular biology 1993;44():109-42.
1992: G Ibeanu; B Hartenstein; W C Dunn; L Y Chang; E Hofmann; T Coquerelle; Sankar Mitra; Bernd Kaina
Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells.
Carcinogenesis 1992;13(11):1989-95.
1992: X M He; L E Ostrowski; M A von Wronski; Henry S Friedman; Carol J Wikstrand; Sandra H Bigner; A Rasheed; Surinder Batra; Sankar Mitra; Thomas P Brent
Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines.
Cancer research 1992;52(5):1144-8.
1992: S Shiota; M A von Wronski; K Tano; Darell D Bigner; Thomas P Brent; Sankar Mitra
Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli.
Biochemistry 1992;31(7):1897-903.
1992: Adayapalam T Natarajan; S Vermeulen; Firouz Darroudi; M B Valentine; Thomas P Brent; Sankar Mitra; K Tano
Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization.
Mutagenesis 1992;7(1):83-5.
1992: M A von Wronski; Linda C Harris; K Tano; Sankar Mitra; Darell D Bigner; Thomas P Brent
Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts.
Oncology research 1992;4(4-5):167-74.
1991: Linda C Harris; Philip Potter; K Tano; S Shiota; Sankar Mitra; Thomas P Brent
Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene.
Nucleic acids research 1991;19(22):6163-7.
1991: Bernd Kaina; Gerhard Fritz; Sankar Mitra; T Coquerelle
Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents.
Carcinogenesis 1991;12(10):1857-67.
1991: K Tano; S Shiota; Joanna S Remack; Thomas P Brent; Darell D Bigner; Sankar Mitra
The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA.
Mutation research 1991;255(2):175-82.
1991: L E Ostrowski; M A von Wronski; Sandra H Bigner; A Rasheed; S Clifford Schold; Thomas P Brent; Sankar Mitra; Darell D Bigner
Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.
Carcinogenesis 1991;12(9):1739-44.
1991: D Chakravarti; G C Ibeanu; K Tano; Sankar Mitra
Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase.
The Journal of biological chemistry 1991;266(24):15710-5.
1991: A Jaberaboansari; W C Dunn; R J Preston; Sankar Mitra; LC Waters
Mutations induced by ionizing radiation in a plasmid replicated in human cells. II. Sequence analysis of alpha-particle-induced point mutations.
Radiation research 1991;127(2):202-10.
1991: LC Waters; M O Sikpi; R J Preston; Sankar Mitra; A Jaberaboansari
Mutations induced by ionizing radiation in a plasmid replicated in human cells. I. Similar, nonrandom distribution of mutations in unirradiated and X-irradiated DNA.
Radiation research 1991;127(2):190-201.
1991: L E Ostrowski; Charles N Pegram; M A Von Wronski; P A Humphrey; X M He; S Shiota; Sankar Mitra; Thomas P Brent; Darell D Bigner
Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase.
Cancer research 1991;51(13):3339-44.
1991: M A von Wronski; S Shiota; K Tano; Sankar Mitra; Darell D Bigner; Thomas P Brent
Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA.
The Journal of biological chemistry 1991;266(2):1064-70.
1991: W C Dunn; K Tano; G J Horesovsky; R J Preston; Sankar Mitra
The role of O6-alkylguanine in cell killing and mutagenesis in Chinese hamster ovary cells.
Carcinogenesis 1991;12(1):83-9.
1990: D Bhattacharyya; Robert S Foote; A M Boulden; Sankar Mitra
Physicochemical studies of human O6-methylguanine-DNA methyltransferase.
European journal of biochemistry / FEBS 1990;193(2):337-43.
1990: K Tano; S Shiota; J Collier; Robert S Foote; Sankar Mitra
Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):686-90.
1990: M O Sikpi; LC Waters; K H Kraemer; R J Preston; Sankar Mitra
N-methyl-N-nitrosourea-induced mutations in a shuttle plasmid replicated in human cells.
Molecular carcinogenesis 1990;3(1):30-6.
1989: S Clifford Schold; Thomas P Brent; E von Hofe; Henry S Friedman; Sankar Mitra; Darell D Bigner; James A Swenberg; P Kleihues
O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts.
Journal of neurosurgery 1989;70(4):573-7.
1989: W J Washington; Robert S Foote; W C Dunn; Walderico M Generoso; Sankar Mitra
Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O6-methylguanine in DNA in inbred mice.
Mechanisms of ageing and development 1989;48(1):43-52.
1989: K Tano; D Bhattacharyya; Robert S Foote; RJ Mural; Sankar Mitra
Site-directed mutation of the Escherichia coli ada gene: effects of substitution of methyl acceptor cysteine-321 by histidine in Ada protein.
Journal of bacteriology 1989;171(3):1535-43.
1988: D Bhattacharyya; K Tano; Gerard J. Bunick; Edward C Uberbacher; W D Behnke; Sankar Mitra
Rapid, large-scale purification and characterization of 'Ada protein' (O6 methylguanine-DNA methyltransferase) of E. coli.
Nucleic acids research 1988;16(14A):6397-410.
1988: K Tano; Robert S Foote; Sankar Mitra
High-level expression of the cloned ada gene of Escherichia coli by deletion of its regulatory sequence.
Gene 1988;64(2):305-11.
1988: D Bhattacharyya; A M Boulden; Robert S Foote; Sankar Mitra
Effect of polyvalent metal ions on the reactivity of human O6-methylguanine-DNA methyltransferase.
Carcinogenesis 1988;9(4):683-5.
1988: W J Washington; W C Dunn; Walderico M Generoso; Sankar Mitra
Tissue-specific variation in repair activity for 3-methyladenine in DNA in two stocks of mice.
Mutation research 1988;207(3-4):165-9.
1987: Fred C Hartman; T S Soper; S K Niyogi; RJ Mural; Robert S Foote; Sankar Mitra; E H Lee; R Machanoff; Frank W Larimer
Function of Lys-166 of Rhodospirillum rubrum ribulosebisphosphate carboxylase/oxygenase as examined by site-directed mutagenesis.
The Journal of biological chemistry 1987;262(8):3496-501.
1986: S K Niyogi; Robert S Foote; RJ Mural; Frank W Larimer; Sankar Mitra; T S Soper; R Machanoff; Fred C Hartman
Nonessentiality of histidine 291 of Rhodospirillum rubrum ribulose-bisphosphate carboxylase/oxygenase as determined by site-directed mutagenesis.
The Journal of biological chemistry 1986;261(22):10087-92.
1986: W C Dunn; Robert S Foote; R E Hand; Sankar Mitra
Cell cycle-dependent modulation of O6-methylguanine-DNA methyltransferase in C3H/10T1/2 cells.
Carcinogenesis 1986;7(5):807-12.