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Alain Beck

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Thierry Champion; Alain Beck
Capture of the human IgG1 antibodies by protein A for the kinetic study of h-IgG/FcγR interaction using SPR-based biosensor technology.
Marie-Claire Janin-Bussat; Christine Klinguer-Hamour; Laure Tonini; Olivier Colas; Nathalie Corvaïa; Céline Huillet; Alain Beck
Cetuximab Fab and Fc N-glycan fast characterization using IdeS digestion and liquid chromatography coupled to electrospray ionization mass spectrometry.
Elsa Wagner-Rousset; Audrey Bednarczyk; Nathalie Corvaïa; Christine Schaeffer-Reiss; Alain Van Dorsselaer; Alain Beck
NanoLC Chips MS/MS for the characterization of N-glycopeptides generated from trypsin digestion of a monoclonal antibody.

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All Publications

2013: Thierry Champion; Alain Beck
Capture of the human IgG1 antibodies by protein A for the kinetic study of h-IgG/FcγR interaction using SPR-based biosensor technology.
Methods in molecular biology (Clifton, N.J.) 2013;988():331-43.
2013: Marie-Claire Janin-Bussat; Christine Klinguer-Hamour; Laure Tonini; Olivier Colas; Nathalie Corvaïa; Céline Huillet; Alain Beck
Cetuximab Fab and Fc N-glycan fast characterization using IdeS digestion and liquid chromatography coupled to electrospray ionization mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2013;988():93-113.
2013: Elsa Wagner-Rousset; Audrey Bednarczyk; Nathalie Corvaïa; Christine Schaeffer-Reiss; Alain Van Dorsselaer; Alain Beck
NanoLC Chips MS/MS for the characterization of N-glycopeptides generated from trypsin digestion of a monoclonal antibody.
Methods in molecular biology (Clifton, N.J.) 2013;988():81-91.
2013: Nathalie Corvaia; Alain Beck; Véronique Caussanel; Liliane Goetsch
Insulin-like growth factor receptor type I as a target for cancer therapy.
Frontiers in bioscience (Scholar edition) 2013;5():439-50.
2010: Alain Beck
Antibody Engineering & Design 2010. 24-25 February 2010, Frankfurt, Germany.
IDrugs : the investigational drugs journal 2010;13(5):295-9.
2010: Marine Foucault; Katia Mayol; Veronique Receveur-Brechot; Marie-Claire Bussat; Christine Klinguer-Hamour; Bernard Verrier; Alain Beck; Richard Haser; Patrice Gouet; Christophe Guillon
UV and X-ray structural studies of a 101-residue long Tat protein from a HIV-1 primary isolate and of its mutated, detoxified, vaccine candidate.
Proteins 2010;78(6):1441-56.
2010: Alain Beck; Olivier Cochet; Thierry Wurch
GlycoFi's technology to control the glycosylation of recombinant therapeutic proteins.
Expert opinion on drug discovery 2010;5(1):95-111.
2009: Thierry Wurch; Peter Lowe; Alain Beck; Nathalie Corvaia
[Protein scaffolds as alternatives to whole antibodies: from discovery research to clinical development].
Médecine sciences : M/S 2009;25(12):1169-72.
2009: Christine Klinguer-Hamour; Véronique Caussanel; Alain Beck
[Monoclonal antibodies for treating infectious diseases].
Médecine sciences : M/S 2009;25(12):1116-20.
2009: Jean-François Haeuw; Véronique Caussanel; Alain Beck
[Immunoconjugates, drug-armed antibodies to fight against cancer].
Médecine sciences : M/S 2009;25(12):1046-52.
2009: Alain Beck; Elsa Wagner-Rousset; Thierry Wurch; Nathalie Corvaia
[Therapeutic antibodies and related products: choosing the right structure for success].
Médecine sciences : M/S 2009;25(12):1024-32.
2009: Josef Vlasak; Marie C Bussat; Shiyi Wang; Elsa Wagner-Rousset; Mark Schaefer; Christine Klinguer-Hamour; Marc Kirchmeier; Nathalie Corvaïa; Roxana Ionescu; Alain Beck
Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.
Analytical biochemistry 2009;392(2):145-54.
2008: Elsa Wagner-Rousset; Audrey Bednarczyk; Marie-Claire Bussat; Olivier Colas; Nathalie Corvaïa; Christine Schaeffer; Alain Van Dorsselaer; Alain Beck
The way forward, enhanced characterization of therapeutic antibody glycosylation: comparison of three level mass spectrometry-based strategies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;872(1-2):23-37.
2007: Alain Beck; Christine Klinguer-Hamour; Marie-Claire Bussat; Thierry Champion; Jean-François Haeuw; Liliane Goetsch; Thierry Wurch; Masae Sugawara; Alain Milon; Alain Van Dorsselaer; Thien Nguyen; Nathalie Corvaïa
Peptides as tools and drugs for immunotherapies.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(9):588-602.
2005: Alain Beck; Marie-Claire Bussat; Nathalie Zorn; Virginie Robillard; Christine Klinguer-Hamour; Stéphane Chenu; Liliane Goetsch; Nathalie Corvaïa; Alain Van Dorsselaer; Jean-François Haeuw
Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;819(2):203-18.
2005: Liliane Goetsch; Alexandra Gonzalez; Olivier Leger; Alain Beck; Petrus J Pauwels; Jean-François Haeuw; Nathalie Corvaia
A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts.
International journal of cancer. Journal international du cancer 2005;113(2):316-28.
2003: Christine Klinguer-Hamour; Marie-Claire Bussat; Hélène Plotnicky; Dominique Velin; Nathalie Corvaïa; Thien Nguyen; Alain Beck
Synthesis, refolding and protective immune responses of a potential antigen for human Respiratory Syncytial Virus vaccine.
The journal of peptide research : official journal of the American Peptide Society 2003;62(1):27-36.
2003: Hélène Plotnicky; Dominique Cyblat-Chanal; Jean-Pierre Aubry; F Derouet; Christine Klinguer-Hamour; Alain Beck; Jean-Yves Bonnefoy; Nathalie Corvaïa
The immunodominant influenza matrix T cell epitope recognized in human induces influenza protection in HLA-A2/K(b) transgenic mice.
Virology 2003;309(2):320-9.
2003: Isabelle Cognet; Amélie Benoit de Coignac; Giovanni Magistrelli; Pascale Jeannin; Jean-Pierre Aubry; Karine Maisnier-Patin; Gersende Caron; Sylvie Chevalier; Frédéric Humbert; Thien Nguyen; Alain Beck; Dominique Velin; Yves Delneste; Martine Malissard; Jean-François Gauchat
Expression of recombinant proteins in a lipid A mutant of Escherichia coli BL21 with a strongly reduced capacity to induce dendritic cell activation and maturation.
Journal of immunological methods 2003;272(1-2):199-210.
2003: Liliane Goetsch; Jean-François Haeuw; Thierry Champion; Christine Lacheny; Thien N'Guyen; Alain Beck; Nathalie Corvaia
Identification of B- and T-cell epitopes of BB, a carrier protein derived from the G protein of Streptococcus strain G148.
Clinical and diagnostic laboratory immunology 2003;10(1):125-32.
2002: Hélène Plotnicky-Gilquin; Dominique Cyblat-Chanal; Liliane Goetsch; Christine Lacheny; Christine Libon; Thierry Champion; Alain Beck; Hélène Pasche; Thien Ngoc Nguyen; Jean-Yves Bonnefoy; Nancy Bouveret-le-Cam; Nathalie Corvaïa
Passive transfer of serum antibodies induced by BBG2Na, a subunit vaccine, in the elderly protects SCID mouse lungs against respiratory syncytial virus challenge.
Virology 2002;303(1):130-7.
2002: Hélène Plotnicky-Gilquin; Dominique Cyblat-Chanal; Jean-Pierre Aubry; Thierry Champion; Alain Beck; Thien Nguyen; Jean-Yves Bonnefoy; Nathalie Corvaïa
Gamma interferon-dependent protection of the mouse upper respiratory tract following parenteral immunization with a respiratory syncytial virus G protein fragment.
Journal of virology 2002;76(20):10203-10.
2002: Christine Klinguer-Hamour; Christine Libon; Hélène Plotnicky-Gilquin; Marie-Claire Bussat; Lydie Revy; Thien Nguyen; Jean-Yves Bonnefoy; Nathalie Corvaïa; Alain Beck
DDA adjuvant induces a mixed Th1/Th2 immune response when associated with BBG2Na, a respiratory syncytial virus potential vaccine.
Vaccine 2002;20(21-22):2743-51.
2002: Aline Blaecke; Yves Delneste; Nathalie Herbault; Pascale Jeannin; Jean-Yves Bonnefoy; Alain Beck; Jean-Pierre Aubry
Measurement of nuclear factor-kappa B translocation on lipopolysaccharide-activated human dendritic cells by confocal microscopy and flow cytometry.
Cytometry 2002;48(2):71-9.
2002: Christine Libon; Jean-François Haeuw; Françoise Crouzet; Chantal Mugnier; Jean-Yves Bonnefoy; Alain Beck; Nathalie Corvaïa
Streptococcus pneumoniae polysaccharides conjugated to the outer membrane protein A from Klebsiella pneumoniae elicit protective antibodies.
Vaccine 2002;20(17-18):2174-80.
2001: Ultan F Power; Thien Ngoc Nguyen; E Rietveld; Rik de Swart; J Groen; A D Osterhaus; R de Groot; Nathalie Corvaia; Alain Beck; Nancy Bouveret-le-Cam; Jean-Yves Bonnefoy
Safety and immunogenicity of a novel recombinant subunit respiratory syncytial virus vaccine (BBG2Na) in healthy young adults.
The Journal of infectious diseases 2001;184(11):1456-60.
2001: Liliane Goetsch; A Gonzalez; Hélène Plotnicky-Gilquin; Jean-François Haeuw; Jean-Pierre Aubry; Alain Beck; Jean-Yves Bonnefoy; Nathalie Corvaïa
Targeting of nasal mucosa-associated antigen-presenting cells in vivo with an outer membrane protein A derived from Klebsiella pneumoniae.
Infection and immunity 2001;69(10):6434-44.
2001: Alain Beck; Liliane Goetsch; Thierry Champion; Marie-Claire Bussat; Jean-Pierre Aubry; Christine Klinguer-Hamour; Jean-François Haeuw; Jean-Yves Bonnefoy; Nathalie Corvaïa
Stability and CTL-activity of P40/ELA melanoma vaccine candidate.
Biologicals : journal of the International Association of Biological Standardization 2001;29(3-4):293-8.
2001: C Klinguer; Alain Beck; P De-Lys; Marie-Claire Bussat; Aline Blaecke; F Derouet; Jean-Yves Bonnefoy; Thien Ngoc Nguyen; Nathalie Corvaïa; Dominique Velin
Lipophilic quaternary ammonium salt acts as a mucosal adjuvant when co-administered by the nasal route with vaccine antigens.
Vaccine 2001;19(30):4236-44.
2001: N Dagouassat; Virginie Robillard; Jean-François Haeuw; Hélène Plotnicky-Gilquin; Ultan F Power; Nathalie Corvaïa; T Nguyen; Jean-Yves Bonnefoy; Alain Beck
A novel bipolar mode of attachment to aluminium-containing adjuvants by BBG2Na, a recombinant subunit hRSV vaccine.
Vaccine 2001;19(30):4143-52.
2001: M Lokteff; Christine Klinguer-Hamour; E Julien; D Picot; L Lannes; Thien Nguyen; Jean-Yves Bonnefoy; Alain Beck
Residual DNA quantification in clinical batches of BBG2Na, a recombinant subunit vaccine against human respiratory syncytial virus.
Biologicals : journal of the International Association of Biological Standardization 2001;29(2):123-32.
2001: Alain Beck; Marie-Claire Bussat; Christine Klinguer-Hamour; Liliane Goetsch; Jean-Pierre Aubry; Thierry Champion; E Julien; Jean-François Haeuw; Jean-Yves Bonnefoy; Nathalie Corvaia
Stability and CTL activity of N-terminal glutamic acid containing peptides.
The journal of peptide research : official journal of the American Peptide Society 2001;57(6):528-38.
2001: N Dagouassat; Jean-François Haeuw; Virginie Robillard; F Damien; Christine Libon; Nathalie Corvaïa; F Lawny; Thien Ngoc Nguyen; Jean-Yves Bonnefoy; Alain Beck
Development of a quantitative assay for residual host cell proteins in a recombinant subunit vaccine against human respiratory syncytial virus.
Journal of immunological methods 2001;251(1-2):151-9.
2001: Ultan F Power; Hélène Plotnicky-Gilquin; Liliane Goetsch; Thierry Champion; Alain Beck; Jean-François Haeuw; Thien Ngoc Nguyen; Jean-Yves Bonnefoy; Nathalie Corvaïa
Identification and characterisation of multiple linear B cell protectopes in the respiratory syncytial virus G protein.
Vaccine 2001;19(17-19):2345-51.
2000: Liliane Goetsch; Hélène Plotnicky-Gilquin; Thierry Champion; Alain Beck; Nathalie Corvaïa; S Stâhl; Jean-Yves Bonnefoy; Thien Ngoc Nguyen; Ultan F Power
Influence of administration dose and route on the immunogenicity and protective efficacy of BBG2Na, a recombinant respiratory syncytial virus subunit vaccine candidate.
Vaccine 2000;18(24):2735-42.
2000: L Goestch; Hélène Plotnicky-Gilquin; Thierry Champion; Alain Beck; Jean-François Haeuw; Thien Nguyen; Jean-Yves Bonnefoy; Nathalie Corvaïa
Influence of live respiratory syncytial virus priming on the immune response generated by a recombinant vaccine candidate, BBG2Na.
Vaccine 2000;18(24):2648-55.
2000: Hélène Plotnicky-Gilquin; Alain Robert; L Chevalet; Jean-François Haeuw; Alain Beck; Jean-Yves Bonnefoy; C Brandt; Claire-Anne Siegrist; Thien Ngoc Nguyen; Ultan F Power
CD4(+) T-cell-mediated antiviral protection of the upper respiratory tract in BALB/c mice following parenteral immunization with a recombinant respiratory syncytial virus G protein fragment.
Journal of virology 2000;74(8):3455-63.
2000: Jean-François Haeuw; Christine Libon; Laurence Zanna; Liliane Goetsch; Thierry Champion; Thien Ngoc Nguyen; Jean-Yves Bonnefoy; Nathalie Corvaia; Alain Beck
Physico-chemical characterization and immunogenicity studies of peptide and polysaccharide conjugate vaccines based on a promising new carrier protein, the recombinant Klebsiella pneumoniae OmpA.
Developments in biologicals 2000;103():245-50.
2000: Alain Beck; Nathalie Zorn; Marie-Claire Bussat; Jean-François Haeuw; Nathalie Corvaïa; Thien Ngoc Nguyen; Alain Van Dorsselaer; Jean-Yves Bonnefoy
Synthesis and characterization of respiratory syncytial virus protein G related peptides containing two disulphide bridges.
Developments in biologicals 2000;103():231-6.
2000: Alain Beck; Nathalie Zorn; Marie-Claire Bussat; Jean-François Haeuw; Nathalie Corvaïa; Thien Ngoc Nguyen; Jean-Yves Bonnefoy; Alain Van Dorsselaer
Synthesis and characterization of Respiratory Syncytial Virus protein G related peptides containing two disulfide bridges.
The journal of peptide research : official journal of the American Peptide Society 2000;55(1):24-35.
1999: Hélène Plotnicky-Gilquin; Liliane Goetsch; T Huss; Thierry Champion; Alain Beck; Jean-François Haeuw; Thien Ngoc Nguyen; Jean-Yves Bonnefoy; Nathalie Corvaïa; Ultan F Power
Identification of multiple protective epitopes (protectopes) in the central conserved domain of a prototype human respiratory syncytial virus G protein.
Journal of virology 1999;73(7):5637-45.
1999: Hélène Plotnicky-Gilquin; T Huss; Jean-Pierre Aubry; Jean-François Haeuw; Alain Beck; Jean-Yves Bonnefoy; Thien Ngoc Nguyen; Ultan F Power
Absence of lung immunopathology following respiratory syncytial virus (RSV) challenge in mice immunized with a recombinant RSV G protein fragment.
Virology 1999;258(1):128-40.
1998: Jean-François Haeuw; I Rauly; Laurence Zanna; Christine Libon; C Andreoni; Thien Ngoc Nguyen; Thierry Baussant; Jean-Yves Bonnefoy; Alain Beck
The recombinant Klebsiella pneumoniae outer membrane protein OmpA has carrier properties for conjugated antigenic peptides.
European journal of biochemistry / FEBS 1998;255(2):446-54.