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Nico Mitro

Research Profile

Chemicals & Drugs

Physiology

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Publications

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Andrea Galmozzi; Elise Gers; Federica Gilardi; Cristina Godio; Alice Gualerzi; Uliano Guerrini; Antonello Mai; Nico Mitro; dante rotili; Enrique Saez; Sergio Valente; Donatella Caruso; Gaia Cermenati; Emma De Fabiani; Elena Donetti; Alessandra Ferrari; Maurizio Crestani
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue.
Nico Mitro; Cristina Godio; Maurizio Crestani
Fluorescence resonance energy transfer techniques to study ligand-mediated interactions of PPARs with coregulators.
Nico Mitro; Elena Scotti; Federica Gilardi; Marco Giudici; Cristina Godio; Maurizio Crestani
Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.

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All Publications

2013: Andrea Galmozzi; Elise Gers; Federica Gilardi; Cristina Godio; Alice Gualerzi; Uliano Guerrini; Antonello Mai; Nico Mitro; dante rotili; Enrique Saez; Sergio Valente; Donatella Caruso; Gaia Cermenati; Emma De Fabiani; Elena Donetti; Alessandra Ferrari; Maurizio Crestani
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue.
Diabetes 2013;62(3):732-42.
2013: Nico Mitro; Cristina Godio; Maurizio Crestani
Fluorescence resonance energy transfer techniques to study ligand-mediated interactions of PPARs with coregulators.
Methods in molecular biology (Clifton, N.J.) 2013;952():219-27.
2013: Nico Mitro; Elena Scotti; Federica Gilardi; Marco Giudici; Cristina Godio; Maurizio Crestani
Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.
Methods in molecular biology (Clifton, N.J.) 2013;952():137-44.
2012: Alessandra Ferrari; Erika Fiorino; Andrea Galmozzi; Federica Gilardi; Marco Giudici; Cristina Godio; Nico Mitro; Donatella Caruso; Gaia Cermenati; Emma De Fabiani; Maurizio Crestani
Linking epigenetics to lipid metabolism: focus on histone deacetylases.
Molecular membrane biology 2012;29(7):257-66.
2012: Nico Mitro; Marzia Pesaresi; Federico Abbiati; Donato Calabrese; Donatella Caruso; Gaia Cermenati; Luis Miguel Garcia-Segura; Silvia Giatti; Roberto C Melcangi
LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals.
Neurochemistry international 2012;60(6):616-21.
2011: Roberto Cosimo Melcangi; Nico Mitro; Marzia Pesaresi; Donato Calabrese; Donatella Caruso; Silvia Giatti; Luis Miguel Garcia-Segura
Role of neuroactive steroids in the peripheral nervous system.
Frontiers in endocrinology 2011;2():104.
2010: Gaia Cermenati; Silvia Giatti; Guido Cavaletti; Roberto Bianchi; Omar Maschi; Marzia Pesaresi; Federico Abbiati; Alessandro Volonterio; Enrique Saez; Donatella Caruso; Roberto Cosimo Melcangi; Nico Mitro
Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(36):11896-901.
2010: Giorgio Pochetti; Nico Mitro; Antonio Lavecchia; Federica Gilardi; Neva Besker; Elena Scotti; Massimiliano Aschi; Nazzareno Re; Giuseppe Fracchiolla; Antonio Laghezza; Paolo Tortorella; Roberta Montanari; Ettore Novellino; Fernando Mazza; Maurizio Crestani; Fulvio Loiodice
Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis.
Journal of medicinal chemistry 2010;53(11):4354-66.
2010: Emma De Fabiani; Donatella Caruso; Andrea Galmozzi; Federica Gilardi; Nico Mitro; Maurizio Crestani
When food meets man: the contribution of epigenetics to health.
Nutrients 2010;2(5):551-71.
2008: Luigi Sironi; Nico Mitro; Mauro Cimino; Paolo Gelosa; Uliano Guerrini; Elena Tremoli; Enrique Saez
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage.
FEBS letters 2008;582(23-24):3396-400.
2008: Chunlei Wu; David L Delano; Nico Mitro; Stephen V Su; Jeff Janes; Phillip McClurg; Serge Batalov; Genevieve L Welch; Jie Zhang; Anthony P Orth; John R Walker; Richard J Glynne; Michael P Cooke; Joseph S Takahashi; Kazuhiro Shimomura; Akira Kohsaka; Joseph Bass; Enrique Saez; Timothy Wiltshire; Andrew Su
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
PLoS genetics 2008;4(5):e1000070.
2008: Nico Mitro; Federica Gilardi; Cristina Godio; Elena Scotti; Emma De Fabiani; Donatella Caruso; Maurizio Crestani
Bile acids and gene regulation: from nuclear receptors to chromatin.
Frontiers in bioscience : a journal and virtual library 2008;13():6276-88.
2007: Federica Gilardi; Nico Mitro; Cristina Godio; Elena Scotti; Donatella Caruso; Maurizio Crestani; Emma De Fabiani
The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.
Pharmacology & therapeutics 2007;116(3):449-72.
2007: S Renee Commerford; Leo Vargas; Suzanne E Dorfman; Nico Mitro; Erik C Rocheford; Puiying A Mak; Xue Li; Patrick Kennedy; Tara L Mullarkey; Enrique Saez
Dissection of the insulin-sensitizing effect of liver X receptor ligands.
Molecular endocrinology (Baltimore, Md.) 2007;21(12):3002-12.
2007: Elena Scotti; Federica Gilardi; Cristina Godio; E Gers; J Krneta; Nico Mitro; Emma De Fabiani; Donatella Caruso; Maurizio Crestani
Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions.
Cellular and molecular life sciences : CMLS 2007;64(19-20):2477-91.
2007: Nico Mitro; Cristina Godio; Emma De Fabiani; Elena Scotti; Andrea Galmozzi; Federica Gilardi; Donatella Caruso; Ana Belen Vigil Chacon; Maurizio Crestani
Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.
Hepatology (Baltimore, Md.) 2007;46(3):885-97.
2007: Valentina Molteni; Xiaolin Li; Juliet Nabakka; Fang Liang; John Wityak; Alan Koder; Leo Vargas; Russell Romeo; Nico Mitro; Puiying A Mak; H Martin Seidel; Jennifer A Haslam; Donald Chow; Tove tuntland; Tracy A Spalding; Ansgar Brock; Michelle Bradley; Antonio Castrillo; Peter Tontonoz; Enrique Saez
N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
Journal of medicinal chemistry 2007;50(17):4255-9.
2007: Giorgio Pochetti; Cristina Godio; Nico Mitro; Donatella Caruso; Andrea Galmozzi; Silvia Scurati; Fulvio Loiodice; Giuseppe Fracchiolla; Paolo Tortorella; Antonio Laghezza; Antonio Lavecchia; Ettore Novellino; Fernando Mazza; Maurizio Crestani
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
The Journal of biological chemistry 2007;282(23):17314-24.
2007: Marco Bertolotti; Chiara Gabbi; Claudia Anzivino; Maurizio Crestani; Nico Mitro; Marina Del Puppo; Cristina Godio; Emma De Fabiani; D Macchioni; Lucia Carulli; A Rossi; Matteo Ricchi; Paola Loria; Nicola Carulli
Age-related changes in bile acid synthesis and hepatic nuclear receptor expression.
European journal of clinical investigation 2007;37(6):501-8.
2007: Hironori Waki; Kye Won Park; Nico Mitro; Liming Pei; Robert Damoiseaux; DAMIEN WILPITZ; Karen Reue; Enrique Saez; Peter Tontonoz
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.
Cell metabolism 2007;5(5):357-70.
2007: Nico Mitro; Leo Vargas; Russell Romeo; Alan Koder; Enrique Saez
T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR.
FEBS letters 2007;581(9):1721-6.
2007: Nico Mitro; Puiying A Mak; Leo Vargas; Cristina Godio; Eric Hampton; Valentina Molteni; Andreas Kreusch; Enrique Saez
The nuclear receptor LXR is a glucose sensor.
Nature 2007;445(7124):219-23.
2006: Mario Dell'Agli; Rossana Fagnani; Nico Mitro; Silvia Scurati; Maura Masciadri; Luciana Mussoni; Giovanni Galli; Enrica Bosisio; Maurizio Crestani; Emma De Fabiani; Elena Tremoli; Donatella Caruso
Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation.
Journal of agricultural and food chemistry 2006;54(9):3259-64.
2006: Marco Bertolotti; Chiara Gabbi; Claudia Anzivino; Nico Mitro; Cristina Godio; Emma De Fabiani; Maurizio Crestani; Marina Del Puppo; Matteo Ricchi; Lucia Carulli; A Rossi; Paola Loria; Nicola Carulli
Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis.
European journal of clinical investigation 2006;36(3):170-5.
2005: Arnaldo Pinelli; Cristina Godio; Antonio Laghezza; Nico Mitro; Giuseppe Fracchiolla; Vincenzo Tortorella; Antonio Lavecchia; Ettore Novellino; Jean-Charles Fruchart; Bart Staels; Maurizio Crestani; Fulvio Loiodice
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Journal of medicinal chemistry 2005;48(17):5509-19.
2005: Donatella Caruso; Maurizio Crestani; Nico Mitro; Luca Da Riva; Roberta Mozzi; S Sarpau; C Merlotti; Carlo Franzini
High pressure liquid chromatography and electrospray ionization mass spectrometry are advantageously integrated into a two-levels approach to detection and identification of haemoglobin variants.
Clinical and laboratory haematology 2005;27(2):111-9.
2004: Emma De Fabiani; Nico Mitro; Cristina Godio; Federica Gilardi; Donatella Caruso; Maurizio Crestani
Bile acid signaling to the nucleus: finding new connections in the transcriptional regulation of metabolic pathways.
Biochimie 2004;86(11):771-8.
2004: Donatella Caruso; Maurizio Crestani; Luca Da Riva; Nico Mitro; Flavio Giavarini; Roberta Mozzi; Carlo Franzini
Mass spectrometry and DNA sequencing are complementary techniques for characterizing hemoglobin variants: the example of hemoglobin J-Oxford.
Haematologica 2004;89(5):608-9.
2004: Maurizio Crestani; Emma De Fabiani; Donatella Caruso; Nico Mitro; Federica Gilardi; A B Vigil Chacon; R Patelli; Cristina Godio; Giovanni Galli
LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.
Biochemical Society transactions 2004;32(Pt 1):92-6.
2003: Emma De Fabiani; Nico Mitro; Federica Gilardi; Donatella Caruso; Giovanni Galli; Maurizio Crestani
Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle.
The Journal of biological chemistry 2003;278(40):39124-32.
2003: Stefano Bellosta; Mario Dell'Agli; Monica Canavesi; Nico Mitro; Mara Monetti; Maurizio Crestani; Luisella Verotta; N Fuzzati; Franco Bernini; Enrica Bosisio
Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae).
Cellular and molecular life sciences : CMLS 2003;60(7):1440-8.
2001: Emma De Fabiani; Nico Mitro; A C Anzulovich; Arnaldo Pinelli; Giovanni Galli; Maurizio Crestani
The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors.
The Journal of biological chemistry 2001;276(33):30708-16.