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Kyriacos Mitrophanous

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Heather M Guy; Gary J Lye; Laura McCloskey; Kyriacos A Mitrophanous; Tarit K Mukhopadhyay
Characterization of Lentiviral Vector Production Using Microwell Suspension Cultures of HEK293T-Derived Producer Cells.
Daniel C Farley; Marie A Leroux-Carlucci; James E Miskin; Richard Bannister; Nerys E Evans; Kyriacos A Mitrophanous
Development of an equine-tropic replication-competent lentivirus assay for equine infectious anemia virus-based lentiviral vectors.
Katie Binley; Marie Carlucci; Daniel Chipchase; Jackie de Belin; Scott Ellis; M Esapa; Georgina Ferrige; Michelle Kelleher; Julie Loader; Paul Miller; James Miskin; Kyriacos A Mitrophanous; Diana Angell-Manning; Vlad Bantseev; T Michael Nork; Peter S Widdowson; Stuart Naylor
Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat(®), for age-related macular degeneration.

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2013: Heather M Guy; Gary J Lye; Laura McCloskey; Kyriacos A Mitrophanous; Tarit K Mukhopadhyay
Characterization of Lentiviral Vector Production Using Microwell Suspension Cultures of HEK293T-Derived Producer Cells.
Human gene therapy methods 2013;24(2):125-39.
2012: Daniel C Farley; Marie A Leroux-Carlucci; James E Miskin; Richard Bannister; Nerys E Evans; Kyriacos A Mitrophanous
Development of an equine-tropic replication-competent lentivirus assay for equine infectious anemia virus-based lentiviral vectors.
Human gene therapy methods 2012;23(5):309-23.
2012: Katie Binley; Marie Carlucci; Daniel Chipchase; Jackie de Belin; Scott Ellis; M Esapa; Georgina Ferrige; Michelle Kelleher; Julie Loader; Paul Miller; James Miskin; Kyriacos A Mitrophanous; Diana Angell-Manning; Vlad Bantseev; T Michael Nork; Peter S Widdowson; Stuart Naylor
Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat(®), for age-related macular degeneration.
Human gene therapy 2012;23(9):980-91.
2012: Scott Ellis; Liang Fong-Wong; Sharifah Iqball; Kyriacos A Mitrophanous; Vinay Thoree; Katie Binley
Assessment of Integration-defective HIV-1 and EIAV Vectors In Vitro and In Vivo.
Molecular therapy. Nucleic acids 2012;1():e60.
2011: Hannah J Stewart; Liang Fong-Wong; Iain Strickland; Daniel Chipchase; Michelle Kelleher; Laura Stevenson; Vinay Thoree; Janine McCarthy; G Scott Ralph; Kyriacos A Mitrophanous; Pippa A Radcliffe
A stable producer cell line for the manufacture of a lentiviral vector for gene therapy of Parkinson's disease.
Human gene therapy 2011;22(3):357-69.
2009: Béchir Jarraya; Sabrina Boulet; G Scott Ralph; Caroline Jan; Gilles Bonvento; Mimoun Azzouz; James E Miskin; Masahiro Shin; thierry delzescaux; Xavier Drouot; Anne-Sophie Hérard; Denise M Day; Emmanuel Brouillet; Susan M Kingsman; Philippe Hantraye; Kyriacos A Mitrophanous; Nicholas D Mazarakis; Stéphane Palfi
Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.
Science translational medicine 2009;1(2):2ra4.
2009: H J Stewart; M A Leroux-Carlucci; C J M Sion; Kyriacos A Mitrophanous; Pippa A Radcliffe
Development of inducible EIAV-based lentiviral vector packaging and producer cell lines.
Gene therapy 2009;16(6):805-14.
2008: Michael J McGrew; Adrian Sherman; Simon G Lillico; Fiona M Ellard; Pippa A Radcliffe; Hazel J Gilhooley; Kyriacos A Mitrophanous; Noemí Cambray; Valerie Wilson; Helen Sang
Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity.
Development (Cambridge, England) 2008;135(13):2289-99.
2008: Pippa A Radcliffe; C J M Sion; Fraser wilkes; E J Custard; G L Beard; Susan M Kingsman; Kyriacos A Mitrophanous
Analysis of factor VIII mediated suppression of lentiviral vector titres.
Gene therapy 2008;15(4):289-97.
2007: J L Howarth; S Kelly; M P Keasey; Colin P J Glover; Y-B Lee; Kyriacos A Mitrophanous; J Paul Chapple; Jean-Marc Gallo; Michael Cheetham; James B Uney
Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(6):1100-5.
2007: Daniel C Farley; Sharifah Iqball; Joanne C Smith; James E Miskin; Susan M Kingsman; Kyriacos A Mitrophanous
Factors that influence VSV-G pseudotyping and transduction efficiency of lentiviral vectors-in vitro and in vivo implications.
The journal of gene medicine 2007;9(5):345-56.
2007: Simon G Lillico; A Sherman; Michael J McGrew; C D Robertson; J Smith; C Haslam; P Barnard; Pippa A Radcliffe; Kyriacos A Mitrophanous; E A Elliot; H M Sang
Oviduct-specific expression of two therapeutic proteins in transgenic hens.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1771-6.
2006: Caroline V Hacker; Conrad A Vink; Theresa W Wardell; Sheena Lee; Peter Treasure; Susan M Kingsman; Kyriacos A Mitrophanous; James E Miskin
The integration profile of EIAV-based vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(4):536-45.
2006: J Miskin; D Chipchase; J Rohll; G Beard; T Wardell; D Angell; H Roehl; D Jolly; Susan M Kingsman; Kyriacos A Mitrophanous
A replication competent lentivirus (RCL) assay for equine infectious anaemia virus (EIAV)-based lentiviral vectors.
Gene therapy 2006;13(3):196-205.
2006: Liang-Fong Wong; Lucy Goodhead; Christine Prat; Kyriacos A Mitrophanous; Susan M Kingsman; Nicholas D Mazarakis
Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications.
Human gene therapy 2006;17(1):1-9.
2005: Elena K Siapati; Brian W Bigger; James Miskin; Daniel Chipchase; Kathryn L Parsley; Kyriacos A Mitrophanous; Michael Themis; Adrian J Thrasher; Dominique Bonnet
Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):537-46.
2005: G Scott Ralph; Pippa A Radcliffe; Denise M Day; Janine M Carthy; Marie A Leroux; Debbie C P Lee; Liang-Fong Wong; Lynsey G Bilsland; Linda Greensmith; Susan M Kingsman; Kyriacos A Mitrophanous; Nicholas D Mazarakis; Mimoun Azzouz
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.
Nature medicine 2005;11(4):429-33.
2005: Susan M Kingsman; Kyriacos A Mitrophanous; John C Olsen
Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE).
Gene therapy 2005;12(1):3-4.
2004: Mimoun Azzouz; Thanh Le; G Scott Ralph; Lucy E Walmsley; Umrao R Monani; Debbie C P Lee; Fraser wilkes; Kyriacos A Mitrophanous; Susan M Kingsman; Arthur H M Burghes; Nicholas D Mazarakis
Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy.
The Journal of clinical investigation 2004;114(12):1726-31.
2004: Simon Waddington; Megha Nivsarkar; Ajay R Mistry; Suzanne Buckley; Geoffrey Kemball-Cook; Karen L Mosley; Kyriacos A Mitrophanous; Pippa Radcliffe; Maxine V Holder; Mairi Brittan; Anastasios Georgiadis; Faisal Al-Allaf; Brian W Bigger; Lisa G Gregory; H Terence Cook; Robin R Ali; Adrian J Thrasher; Edward G D Tuddenham; Michael Themis; Charles Coutelle
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.
Blood 2004;104(9):2714-21.
2004: C Bruce A Whitelaw; Pippa A Radcliffe; William A Ritchie; Ailsa Carlisle; Fiona M Ellard; Romi N Pena; Jo Rowe; A John Clark; Tim J King; Kyriacos A Mitrophanous
Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector.
FEBS letters 2004;571(1-3):233-6.
2004: Michael J McGrew; Adrian Sherman; Fiona M Ellard; Simon G Lillico; Hazel J Gilhooley; Alan J Kingsman; Kyriacos A Mitrophanous; Helen Sang
Efficient production of germline transgenic chickens using lentiviral vectors.
EMBO reports 2004;5(7):728-33.
2004: Lisa G Gregory; Simon Waddington; Maxine V Holder; Kyriacos A Mitrophanous; Suzanne Buckley; Karen L Mosley; Brian W Bigger; Fiona M Ellard; Lucy E Walmsley; Lorraine Lawrence; Faisal Al-Allaf; Susan M Kingsman; Charles Coutelle; Michael Themis
Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.
Gene therapy 2004;11(14):1117-25.
2004: Mimoun Azzouz; G Scott Ralph; Erik Storkebaum; Lucy E Walmsley; Kyriacos A Mitrophanous; Susan M Kingsman; Peter Carmeliet; Nicholas D Mazarakis
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model.
Nature 2004;429(6990):413-7.
2004: Mimoun Azzouz; Scott Ralph; Liang-Fong Wong; Denise Day; Zoe Askham; Robert D Barber; Kyriacos A Mitrophanous; Susan M Kingsman; Nicholas D Mazarakis
Neuroprotection in a rat Parkinson model by GDNF gene therapy using EIAV vector.
Neuroreport 2004;15(6):985-90.
2004: Liang-Fong Wong; Mimoun Azzouz; Lucy E Walmsley; Zoe Askham; Fraser wilkes; Kyriacos A Mitrophanous; Susan M Kingsman; Nicholas D Mazarakis
Transduction patterns of pseudotyped lentiviral vectors in the nervous system.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):101-11.
2003: Catherine S Adamson; Adam Davies; Yuko Soneoka; Milan V Nermut; Kyriacos A Mitrophanous; Ian M Jones
A block in virus-like particle maturation following assembly of murine leukaemia virus in insect cells.
Virology 2003;314(2):488-96.
2003: Simon Waddington; Kyriacos A Mitrophanous; Fiona M Ellard; Suzanne Buckley; Megha Nivsarkar; Lorraine Lawrence; H Terence Cook; Faisal Al-Allaf; Brian W Bigger; Susan M Kingsman; Charles Coutelle; Michael Themis
Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.
Gene therapy 2003;10(15):1234-40.
2003: Alison S Bienemann; Enca Martin-Rendon; A Siobhan Cosgrave; Colin P J Glover; Liang-Fong Wong; Susan M Kingsman; Kyriacos A Mitrophanous; Nicholas D Mazarakis; James B Uney
Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(5 Pt 1):588-96.
2003: Yasuhiro Ikeda; Yasuhiro Takeuchi; Francisco Martin; François-Loïc Cosset; Kyriacos A Mitrophanous; Mary Collins
Continuous high-titer HIV-1 vector production.
Nature biotechnology 2003;21(5):569-72.
2002: Mimoun Azzouz; Enca Martin-Rendon; Robert D Barber; Kyriacos A Mitrophanous; Emma E Carter; Jonathan B Rohll; Susan M Kingsman; Alan J Kingsman; Nicholas D Mazarakis
Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(23):10302-12.
2002: Jonathan Corcoran; Po-Lin So; Robert D Barber; Karen J Vincent; Nicholas D Mazarakis; Kyriacos A Mitrophanous; Susan M Kingsman; Malcolm Maden
Retinoic acid receptor beta2 and neurite outgrowth in the adult mouse spinal cord in vitro.
Journal of cell science 2002;115(Pt 19):3779-86.
2002: Y Ikeda; Mary K Collins; Pippa A Radcliffe; Kyriacos A Mitrophanous; Yasuhiro Takeuchi
Gene transduction efficiency in cells of different species by HIV and EIAV vectors.
Gene therapy 2002;9(14):932-8.
2002: Enca Martin-Rendon; Linda J White; Anna Olsen; Kyriacos A Mitrophanous; Nicholas D Mazarakis
New methods to titrate EIAV-based lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(5 Pt 1):566-70.
2002: Jonathan B Rohll; Kyriacos A Mitrophanous; Enca Martin-Rendon; Fiona M Ellard; Pippa A Radcliffe; Nicholas D Mazarakis; Susan M Kingsman
Design, production, safety, evaluation, and clinical applications of nonprimate lentiviral vectors.
Methods in enzymology 2002;346():466-500.
2001: Nicholas D Mazarakis; Mimoun Azzouz; Jonathan B Rohll; Fiona M Ellard; Fraser wilkes; A L Olsen; E E Carter; Robert D Barber; DF Baban; Susan M Kingsman; Alan J Kingsman; K O'Malley; Kyriacos A Mitrophanous
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery.
Human molecular genetics 2001;10(19):2109-21.
2000: S Yoon; Susan M Kingsman; Alan J Kingsman; SA Wilson; Kyriacos A Mitrophanous
Characterization of the equine infectious anaemia virus S2 protein.
The Journal of general virology 2000;81(Pt 9):2189-94.
2000: L A King; Kyriacos A Mitrophanous; L A Clark; VN Kim; Jonathan B Rohll; Alan J Kingsman; Raymond J Colello
Growth factor enhanced retroviral gene transfer to the adult central nervous system.
Gene therapy 2000;7(13):1103-11.
2000: E Kotsopoulou; VN Kim; Alan J Kingsman; Susan M Kingsman; Kyriacos A Mitrophanous
A Rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimized HIV-1 gag-pol gene.
Journal of virology 2000;74(10):4839-52.
1999: Kyriacos A Mitrophanous; S Yoon; J Rohll; D Patil; Fraser wilkes; VN Kim; Susan M Kingsman; Alan J Kingsman; Nicholas D Mazarakis
Stable gene transfer to the nervous system using a non-primate lentiviral vector.
Gene therapy 1999;6(11):1808-18.
1998: VN Kim; Kyriacos A Mitrophanous; Susan M Kingsman; Alan J Kingsman
Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1.
Journal of virology 1998;72(1):811-6.