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Norisato Mitsutake

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Chernobyl Nuclear Accident

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Kazuya Kashiyama; Alan R Lehmann; Susan O Lewin; Tao-Sheng Li; David McGibbon; Norisato Mitsutake; Yuji Nagayama; Yuka Nakazawa; Tiziana Nardo; Daniela T Pilz; Robert Sarkany; Kensaku Sasaki; Mayuko Shimada; Miria Stefanini; Yoshito Takahashi; Atsushi Utani; Jonathan F Wing; Shunichi Yamashita; Koh-ichiro Yoshiura; Lucinda Carr; Hiva Fassihi; Heather Fawcett; Danielle Greenblatt; Chaowan Guo; Akiyoshi Hirano; Tomoo Ogi
Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia.
Michiko Matsuse; Norisato Mitsutake; Akira Miyauchi; Eijun Nishihara; Tomoo Ogi; Vladimir A Saenko; Keiji Suzuki; Susumu Tanimura; Cesar S Fuziwara; Mitsuyoshi Hirokawa; Shunichi Yamashita
Functional characterization of the novel BRAF complex mutation, BRAF(V600delinsYM) , identified in papillary thyroid carcinoma.
Rodrigo Hamuy; Kenji Hayashida; Akiyoshi Hirano; Seiji Houbara; Kazuya Kashiyama; Naoshi Kinoshita; Norisato Mitsutake; Zhanna Mussazhanova; Masahiro Nakashima; Keiji Suzuki; Hiroshi Yoshimoto; sadanori akita
One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation.

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2013: Kazuya Kashiyama; Alan R Lehmann; Susan O Lewin; Tao-Sheng Li; David McGibbon; Norisato Mitsutake; Yuji Nagayama; Yuka Nakazawa; Tiziana Nardo; Daniela T Pilz; Robert Sarkany; Kensaku Sasaki; Mayuko Shimada; Miria Stefanini; Yoshito Takahashi; Atsushi Utani; Jonathan F Wing; Shunichi Yamashita; Koh-ichiro Yoshiura; Lucinda Carr; Hiva Fassihi; Heather Fawcett; Danielle Greenblatt; Chaowan Guo; Akiyoshi Hirano; Tomoo Ogi
Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia.
American journal of human genetics 2013;92(5):807-19.
2013: Michiko Matsuse; Norisato Mitsutake; Akira Miyauchi; Eijun Nishihara; Tomoo Ogi; Vladimir A Saenko; Keiji Suzuki; Susumu Tanimura; Cesar S Fuziwara; Mitsuyoshi Hirokawa; Shunichi Yamashita
Functional characterization of the novel BRAF complex mutation, BRAF(V600delinsYM) , identified in papillary thyroid carcinoma.
International journal of cancer. Journal international du cancer 2013;132(3):738-43.
2013: Rodrigo Hamuy; Kenji Hayashida; Akiyoshi Hirano; Seiji Houbara; Kazuya Kashiyama; Naoshi Kinoshita; Norisato Mitsutake; Zhanna Mussazhanova; Masahiro Nakashima; Keiji Suzuki; Hiroshi Yoshimoto; sadanori akita
One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2013;21(1):141-54.
2012: EunSook Kim; Michiko Matsuse; Norisato Mitsutake; Akira Ohtsuru; Vladimir Saenko; Keiji Suzuki; Shunichi Yamashita
Imatinib enhances docetaxel-induced apoptosis through inhibition of nuclear factor-κB activation in anaplastic thyroid carcinoma cells.
Thyroid : official journal of the American Thyroid Association 2012;22(7):717-24.
2012: Kazuya Kashiyama; Michiko Matsuse; Norisato Mitsutake; Tomoo Ogi; Vladimir A Saenko; Kenta Ujifuku; Atsushi Utani; Akiyoshi Hirano; Shunichi Yamashita
miR-196a downregulation increases the expression of type I and III collagens in keloid fibroblasts.
The Journal of investigative dermatology 2012;132(6):1597-604.
2012: Yuka Nakazawa; Tiziana Nardo; Masayo Nomura; Kosei Ito; Akira Kinoshita; Takashi Kudo; Alan R Lehmann; Ritsuko Masuyama; Michiko Matsuse; Hiroyuki Mishima; Norisato Mitsutake; Kaname Ohyama; Shinji Ono; Kensaku Sasaki; Mayuko Shimada; Hanoch Slor; Miria Stefanini; Yoshito Takahashi; Katsuya Takenaka; Satoshi Tateishi; Atsushi Utani; Shunichi Yamashita; Koh-ichiro Yoshiura; Tomoo Ogi
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.
Nature genetics 2012;44(5):586-92.
2012: Julio C Ricarte-Filho; Mabel Ryder; Shunichi Yamashita; Ronald A Ghossein; Marc Ladanyi; Christopher Lau; Michiko Matsuse; Norisato Mitsutake; Eijun Nishihara; James A Fagin
Absence of common activating mutations of the epidermal growth factor receptor gene in thyroid cancers from American and Japanese patients.
International journal of cancer. Journal international du cancer 2012;130(9):2215-7; author reply 2217-8.
2012: Tomoo Ogi; Katrina Prescott; Grant S Stewart; Tom Stiff; Mohnish Suri; A Malcolm R Taylor; Pradeep Vasudevan; Sarah Walker; Margaret Barrow; Philip J Byrd; Gillian Carpenter; Emma Hobson; Siripan Limsirichaikul; Michiko Matsuse; Norisato Mitsutake; Yuka Nakazawa; Mark O'Driscoll; Penny A Jeggo
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.
PLoS genetics 2012;8(11):e1002945.
2012: Michiko Matsuse; Shigeki Minami; Norisato Mitsutake; Eijun Nishihara; Vladimir Saenko; Kensaku Sasaki; Keiji Suzuki; Chisa Hayashida; Hisayoshi Kondo; Koh-ichiro Yoshiura; Shunichi Yamashita
Copy number alteration and uniparental disomy analysis categorizes Japanese papillary thyroid carcinomas into distinct groups.
PloS one 2012;7(4):e36063.
2011: Michiko Matsuse; Norisato Mitsutake; Akira Miyauchi; Eijun Nishihara; Tatiana Rogounovitch; Vladimir Saenko; Keiji Suzuki; Kazuo Tajima; Meiko Takahashi; Ryo Yamada; Andrey Bychkov; Mitsuyoshi Hirokawa; Takahisa Kawaguchi; Fumihiko Matsuda; Keitaro Matsuo; Shunichi Yamashita
The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population.
Journal of medical genetics 2011;48(9):645-8.
2011: Yasuyoshi Oka; Keiji Suzuki; Norisato Mitsutake; Motohiro Yamauchi; Shunichi Yamashita
Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells.
Biochemical and biophysical research communications 2011;411(4):762-7.
2011: Norisato Mitsutake
[Molecular-targeted therapy for thyroid cancer: from bench to bedside].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 2():376-80.
2011: Pavel O Rumyantsev; Vladimir A Saenko; Alexey A Ilyin; Valery F Stepanenko; Ulyana V Rumyantseva; Alexander Abrosimov; Eugeny Lushnikov; Tatiana Rogounovitch; Yoshisada Shibata; Norisato Mitsutake; Anatoly F Tsyb; Shunichi Yamashita
Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer.
The Journal of clinical endocrinology and metabolism 2011;96(2):385-93.
2011: Keiji Suzuki; Norisato Mitsutake; Vladimir Saenko; Masatoshi Suzuki; Michiko Matsuse; Akira Ohtsuru; Atsushi Kumagai; Tatsuya Uga; Hiroshi Yano; Yuji Nagayama; Shunichi Yamashita
Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction.
PloS one 2011;6(4):e19354.
2011: Boban Stanojevic; Radan Dzodic; Vladimir Saenko; Zorka Milovanovic; Gordana Pupic; Ognjen Zivkovic; Ivan Markovic; Igor Djurisic; Marko Buta; Bogomir Dimitrijevic; Tatiana Rogounovitch; Norisato Mitsutake; Mariko Mine; Yoshisada Shibata; Masahiro Nakashima; Shunichi Yamashita
Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia.
Endocrine journal 2011;58(5):381-93.
2011: Kayoko Matsushima; Hajime Isomoto; Naoyuki Yamaguchi; Naoki Inoue; Haruhisa Machida; Toshiyuki Nakayama; Tomayoshi Hayashi; Masaki Kunizaki; Shigekazu Hidaka; Takeshi Nagayasu; Masahiro Nakashima; Kenta Ujifuku; Norisato Mitsutake; Akira Ohtsuru; Shunichi Yamashita; Manav Korpal; Yibin Kang; Philip A Gregory; Gregory J Goodall; Shigeru Kohno; Kazuhiko Nakao
MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells.
Journal of translational medicine 2011;9():30.
2010: Kenta Ujifuku; Norisato Mitsutake; Shu Takakura; Michiko Matsuse; Vladimir Saenko; Keiji Suzuki; Kentaro Hayashi; Takayuki Matsuo; Kensaku Kamada; Izumi Nagata; Shunichi Yamashita
miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells.
Cancer letters 2010;296(2):241-8.
2010: Mami Nakahara; Norisato Mitsutake; Hikaru Sakamoto; Chun-Rong Chen; Basil Rapoport; Sandra M McLachlan; Yuji Nagayama
Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice.
Endocrinology 2010;151(8):4047-54.
2010: Meiko Takahashi; Vladimir A Saenko; Tatiana Rogounovitch; Takahisa Kawaguchi; Valentina M Drozd; Hisako Takigawa-Imamura; Natallia M Akulevich; Chanavee Ratanajaraya; Norisato Mitsutake; Noboru Takamura; Larisa I Danilova; Maxim L Lushchik; Yuri E Demidchik; Simon Heath; Ryo Yamada; Mark Lathrop; Fumihiko Matsuda; Shunichi Yamashita
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
Human molecular genetics 2010;19(12):2516-23.
2010: Norisato Mitsutake; Shunichi Yamashita
[Radiation exposure and development of thyroid cancer].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2010;99(4):786-91.
2009: Norisato Mitsutake; Shunichi Yamashita
[The role of cancer genes in thyroid cancer and molecular targeted therapy].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2009;98(8):1999-2005.
2009: Michiko Matsuse; Norisato Mitsutake; Eijun Nishihara; Tatiana Rogounovitch; Vladimir Saenko; Pavel Rumyantsev; Eugeny Lushnikov; Keiji Suzuki; Akira Miyauchi; Shunichi Yamashita
Lack of GNAQ hotspot mutation in papillary thyroid carcinomas.
Thyroid : official journal of the American Thyroid Association 2009;19(8):921-2.
2009: Ohki Saitoh; Norisato Mitsutake; Toshiyuki Nakayama; Yuji Nagayama
Fibroblast-mediated in vivo and in vitro growth promotion of tumorigenic rat thyroid carcinoma cells but not normal Fisher rat thyroid follicular cells.
Thyroid : official journal of the American Thyroid Association 2009;19(7):735-42.
2009: Natallia M Akulevich; Vladimir A Saenko; Tatiana Rogounovitch; Valentina M Drozd; Eugeny Lushnikov; Victor K Ivanov; Norisato Mitsutake; Ryo Kominami; Shunichi Yamashita
Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma.
Endocrine-related cancer 2009;16(2):491-503.
2009: Xu Chen; Norisato Mitsutake; Krista LaPerle; Nagako Akeno; Pat Zanzonico; Valerie A Longo; Shin Mitsutake; Edna T Kimura; Hartmut Geiger; Eugenio Santos; Hans-Guido Wendel; Aime Franco; Jeffrey A Knauf; James A Fagin
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7979-84.
2009: Michiko Matsuse; Norisato Mitsutake; Tatiana Rogounovitch; Vladimir Saenko; Yuka Nakazawa; Pavel Rumyantsev; Eugeny Lushnikov; Keiji Suzuki; Shunichi Yamashita
Mutation analysis of RAP1 gene in papillary thyroid carcinomas.
Endocrine journal 2009;56(1):161-4.
2008: Zhaowei Meng; Norisato Mitsutake; Masahiro Nakashima; Dmitriy Starenki; Michiko Matsuse; Shu Takakura; Hiroyuki Namba; Vladimir Saenko; Kazuo Umezawa; Akira Ohtsuru; Shunichi Yamashita
Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.
Endocrinology 2008;149(11):5357-65.
2008: Sachio Makino; Norisato Mitsutake; Masahiro Nakashima; Vladimir Saenko; Akira Ohtsuru; Kazuo Umezawa; Katsumi Tanaka; Akiyoshi Hirano; Shunichi Yamashita
DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts.
Journal of dermatological science 2008;51(3):171-80.
2008: Yuka Nakazawa; Vladimir Saenko; Tatiana Rogounovitch; Keiji Suzuki; Norisato Mitsutake; Michiko Matsuse; Shunichi Yamashita
Reciprocal paracrine interactions between normal human epithelial and mesenchymal cells protect cellular DNA from radiation-induced damage.
International journal of radiation oncology, biology, physics 2008;71(2):567-77.
2008: Shu Takakura; Norisato Mitsutake; Masahiro Nakashima; Hiroyuki Namba; Vladimir Saenko; Tatiana Rogounovitch; Yuka Nakazawa; Tomayoshi Hayashi; Akira Ohtsuru; Shunichi Yamashita
Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells.
Cancer science 2008;99(6):1147-54.
2008: Michiko Matsuse; Vladimir Saenko; Ilya Sedliarou; Tatiana Rogounovitch; Yuka Nakazawa; Norisato Mitsutake; Natallia Akulevich; Hiroyuki Namba; Shunichi Yamashita
A novel role for thyroid hormone receptor beta in cellular radiosensitivity.
Journal of radiation research 2008;49(1):17-27.
2007: Ilya Sedliarou; Michiko Matsuse; Vladimir Saenko; Tatiana Rogounovitch; Yuka Nakazawa; Norisato Mitsutake; Hiroyuki Namba; Y Nagayama; Shunichi Yamashita
Overexpression of wild-type THRbeta1 suppresses the growth and invasiveness of human papillary thyroid cancer cells.
Anticancer research 2007;27(6B):3999-4009.
2007: Shunichi Yamashita; Norisato Mitsutake
[Molecular mechanism of thyroid carcinogenesis].
Nihon rinsho. Japanese journal of clinical medicine 2007;65(11):1959-65.
2007: Norisato Mitsutake; Atsuhiko Iwao; Kazuhiro Nagai; Hiroyuki Namba; Akira Ohtsuru; Vladimir Saenko; Shunichi Yamashita
Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively.
Endocrinology 2007;148(4):1797-803.
2007: Alexander Abrosimov; Vladimir Saenko; Serik Meirmanov; Masahiro Nakashima; Tatiana Rogounovitch; Olesya Shkurko; Eugeny Lushnikov; Norisato Mitsutake; Hiroyuki Namba; Shunichi Yamashita
The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression.
Endocrine pathology 2007;18(2):68-75.
2007: Alexander Abrosimov; Vladimir Saenko; Tatiana Rogounovitch; Hiroyuki Namba; Eugeny Lushnikov; Norisato Mitsutake; Shunichi Yamashita
Different structural components of conventional papillary thyroid carcinoma display mostly identical BRAF status.
International journal of cancer. Journal international du cancer 2007;120(1):196-200.
2006: Iryna Palona; Hiroyuki Namba; Norisato Mitsutake; Dmitriy Starenki; Alexei Podtcheko; Ilya Sedliarou; Akira Ohtsuru; Vladimir Saenko; Yuji Nagayama; Kazuo Umezawa; Shunichi Yamashita
BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activation.
Endocrinology 2006;147(12):5699-707.
2006: Cleo Mesa; mana mirza; Norisato Mitsutake; Maureen Sartor; Mario Medvedovic; Craig R Tomlinson; Jeffrey A Knauf; Georg F Weber; James A Fagin
Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling.
Cancer research 2006;66(13):6521-9.
2006: Atsushi Kumagai; Hiroyuki Namba; Norisato Mitsutake; Vladimir Saenko; Akira Ohtsuru; Masahiro Ito; Jaeduk Yoshimura Noh; Kiminori Sugino; Koichi Ito; Shunichi Yamashita
Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation.
Oncology reports 2006;16(1):123-6.
2006: Dmitry Bulgin; Alexei Podtcheko; Shu Takakura; Norisato Mitsutake; Hiroyuki Namba; Vladimir Saenko; Akira Ohtsuru; Tatiana Rogounovitch; Iryna Palona; Shunichi Yamashita
Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest.
Thyroid : official journal of the American Thyroid Association 2006;16(3):217-24.
2006: Norisato Mitsutake; Makoto Miyagishi; Shin Mitsutake; Nagako Akeno; Cleo Mesa; Jeffrey A Knauf; Lei Zhang; Kazunari Taira; James A Fagin
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis.
Endocrinology 2006;147(2):1014-9.
2005: Efisio Puxeddu; Jeffrey A Knauf; Maureen Sartor; Norisato Mitsutake; Eric P Smith; Mario Medvedovic; Craig R Tomlinson; Sonia Moretti; James A Fagin
RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response.
Endocrine-related cancer 2005;12(2):319-34.
2005: Jeffrey A Knauf; Xiaolan Ma; Eric P Smith; Lei Zhang; Norisato Mitsutake; Xiao-Hui Liao; Samuel Refetoff; Yuri E Nikiforov; James A Fagin
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
Cancer research 2005;65(10):4238-45.
2005: Norisato Mitsutake; Jeffrey A Knauf; Shin Mitsutake; Cleo Mesa; Lei Zhang; James A Fagin
Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells.
Cancer research 2005;65(6):2465-73.
2003: Efisio Puxeddu; Norisato Mitsutake; Jeffrey A Knauf; Sonia Moretti; Hei W Kim; Karen A Seta; Diane E Brockman; Leslie Myatt; David E Millhorn; James A Fagin
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway.
The Journal of biological chemistry 2003;278(52):52131-8.
2003: Alexei Podtcheko; Akira Ohtsuru; Satoshi Tsuda; Hiroyuki Namba; Vladimir Saenko; Masahiro Nakashima; Norisato Mitsutake; Shigeru Kanda; Junichi Kurebayashi; Shunichi Yamashita
The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells.
The Journal of clinical endocrinology and metabolism 2003;88(4):1889-96.
2002: Katsu Ishigaki; Hiroyuki Namba; Masahiro Nakashima; Toshiyuki Nakayama; Norisato Mitsutake; Tomayoshi Hayashi; Shigeto Maeda; Makoto Ichinose; Takashi Kanematsu; Shunichi Yamashita
Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer.
The Journal of clinical endocrinology and metabolism 2002;87(7):3433-40.
2002: Norisato Mitsutake; Hiroyuki Namba; K Takahara; Katsu Ishigaki; J Ishigaki; H Ayabe; Shunichi Yamashita
Tie-2 and angiopoietin-1 expression in human thyroid tumors.
Thyroid : official journal of the American Thyroid Association 2002;12(2):95-9.
2001: SS Shklyaev; Hiroyuki Namba; Sautin Yuri; Norisato Mitsutake; Y Nagayama; N Ishikawa; K Ito; K Zeki; Shunichi Yamashita
Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells.
Anticancer research 2001;21(4A):2569-75.
2001: SS Shklyaev; Hiroyuki Namba; Norisato Mitsutake; GK Alipov; Y Nagayama; S Maeda; Akira Ohtsuru; H Tsubouchi; Shunichi Yamashita
Transient activation of c-Jun NH2-terminal kinase by growth factors influences survival but not apoptosis of human thyrocytes.
Thyroid : official journal of the American Thyroid Association 2001;11(7):629-36.
2001: Norisato Mitsutake; Hiroyuki Namba; SS Shklyaev; T Tsukazaki; Akira Ohtsuru; M Ohba; T Kuroki; H Ayabe; Shunichi Yamashita
PKC delta mediates ionizing radiation-induced activation of c-Jun NH(2)-terminal kinase through MKK7 in human thyroid cells.
Oncogene 2001;20(8):989-96.