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Hiroaki Mitsuya

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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HIV-1
HIV

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Co-Publications
Name
40
Yarchoan, Robert
25
Johns, David
21
Asou, Norio
17
Matsuoka, Masao
16
Hata, Hiroyuki
14
Horikawa, Kentaro
14
Kavlick, Mark
13
Ghosh, Arun
13
Zemlicka, Jiri
12
Kodama, Eiichi
12
Marquez, Victor
12
Kohgo, Satoru
12
Pluda, James
11
Ohrui, Hiroshi
11
Nakata, Hirotomo

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Publications

TOP 3
Iwanaga Eisaku; Nakamura Miki; Nanri Tomoko; Kawakita Toshiro; Horikawa Kentaro; Mitsuya Hiroaki; Asou Norio
Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARA.
Hattori Shinichiro; Ide Kazuhiko; Nakata Hirotomo; Harada Hideki; Suzu Shinya; Ashida Noriyuki; Kohgo Satoru; Hayakawa Hiroyuki; Mitsuya Hiroaki; Okada Seiji
Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.
Ghosh Arun K; Leshchenko-Yashchuk Sofiya; Anderson David D; Baldridge Abigail; Noetzel Marcus; Miller Heather B; Tie Yunfeng; Wang Yuan-Fang; Koh Yasuhiro; Weber Irene T; Mitsuya Hiroaki
Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies.

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All Publications

2009: Iwanaga Eisaku; Nakamura Miki; Nanri Tomoko; Kawakita Toshiro; Horikawa Kentaro; Mitsuya Hiroaki; Asou Norio
Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARA.
European journal of haematology 2009;83(5):499-501.
2009: Hattori Shinichiro; Ide Kazuhiko; Nakata Hirotomo; Harada Hideki; Suzu Shinya; Ashida Noriyuki; Kohgo Satoru; Hayakawa Hiroyuki; Mitsuya Hiroaki; Okada Seiji
Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.
Antimicrobial agents and chemotherapy 2009;53(9):3887-93.
2009: Ghosh Arun K; Leshchenko-Yashchuk Sofiya; Anderson David D; Baldridge Abigail; Noetzel Marcus; Miller Heather B; Tie Yunfeng; Wang Yuan-Fang; Koh Yasuhiro; Weber Irene T; Mitsuya Hiroaki
Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies.
Journal of medicinal chemistry 2009;52(13):3902-14.
2009: Aoki Manabu; Venzon David J; Koh Yasuhiro; Aoki-Ogata Hiromi; Miyakawa Toshikazu; Yoshimura Kazuhisa; Maeda Kenji; Mitsuya Hiroaki
Non-cleavage site gag mutations in amprenavir-resistant human immunodeficiency virus type 1 (HIV-1) predispose HIV-1 to rapid acquisition of amprenavir resistance but delay development of resistance to other protease inhibitors.
Journal of virology 2009;83(7):3059-68.
2009: Iwanaga Eisaku; Nanri Tomoko; Matsuno Naofumi; Kawakita Toshiro; Mitsuya Hiroaki; Asou Norio
A JAK2-V617F activating mutation in addition to KIT and FLT3 mutations is associated with clinical outcome in patients with t(8;21)(q22;q22) acute myeloid leukemia.
Haematologica 2009;94(3):433-5.
2009: Nanri Tomoko; Iwanaga Eisaku; Fujie Satomi; Yamada Yasuhiro; Horikawa Kentaro; Mitsuya Hiroaki; Asou Norio
Micafungin-induced immune hemolysis attacks.
International journal of hematology 2009;89(2):139-41.
2009: Koh Yasuhiro; Das Debananda; Leschenko Sofiya; Nakata Hirotomo; Ogata-Aoki Hiromi; Amano Masayuki; Nakayama Maki; Ghosh Arun K; Mitsuya Hiroaki
GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitro.
Antimicrobial agents and chemotherapy 2009;53(3):997-1006.
2009: Tatetsu Hiro; Matsuno Fumihiko; Takatsu Noritaka; Miyake Hirosada; Hoshino Koyu; Nosaka Kisato; Horikawa Kentaro; Hata Hiroyuki; Mitsuya Hiroaki; Asou Norio
Treatment of therapy-related acute myeloid leukemia occurring in elderly non-Hodgkin lymphoma patients with low-dose cytarabine, aclarubicin and granulocyte colony-stimulating factor.
Leukemia research 2009;33(1):197-200.
2008: Yamada Yasuhiro; Ito Kiyoharu; Watanabe Yuko; Nosaka Kisato; Horikawa Kentaro; Hidaka Michihiro; Kawano Fumio; Sasaki Yutaka; Mitsuya Hiroaki; Asou Norio
Allogeneic bone marrow transplantation after L-asparaginase-induced pancreatitis in a patient with acute lymphoblastic leukemia.
Leukemia research 2008;32(12):1944-6.
2008: Ghosh Arun K; Chapsal Bruno D; Baldridge Abigail; Ide Kazuhiko; Koh Yashiro; Mitsuya Hiroaki
Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors.
Organic letters 2008;10(22):5135-8.
2008: Ghosh Arun K; Gemma Sandra; Takayama Jun; Baldridge Abigail; Leshchenko-Yashchuk Sofiya; Miller Heather B; Wang Yuan-Fang; Kovalevsky Andrey Y; Koh Yashiro; Weber Irene T; Mitsuya Hiroaki
Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies.
Organic & biomolecular chemistry 2008;6(20):3703-13.
2008: Kikukawa Yoshitaka; Okuno Yutaka; Tatetsu Hiro; Nakamura Miki; Harada Naoko; Ueno Shikiko; Kamizaki Yorinori; Mitsuya Hiroaki; Hata Hiroyuki
Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid.
International journal of oncology 2008;33(4):807-14.
2008: Ghosh Arun K; Gemma Sandra; Baldridge Abigail; Wang Yuan-Fang; Kovalevsky Andrey Yu; Koh Yashiro; Weber Irene T; Mitsuya Hiroaki
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies.
Journal of medicinal chemistry 2008;51(19):6021-33.
2008: Maeda Kenji; Das Debananda; Yin Philip D; Tsuchiya Kiyoto; Ogata-Aoki Hiromi; Nakata Hirotomo; Norman Rachael B; Hackney Lauren A; Takaoka Yoshikazu; Mitsuya Hiroaki
Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition.
Journal of molecular biology 2008;381(4):956-74.
2008: Hamada Akinobu; Sissung Tristan; Price Douglas K; Danesi Romano; Chau Cindy H; Sharifi Nima; Venzon David; Maeda Kenji; Nagao Keisuke; Sparreboom Alex; Mitsuya Hiroaki; Dahut William L; Figg William D
Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3312-8.
2008: Nakata Hirotomo; Steinberg Seth M; Koh Yasuhiro; Maeda Kenji; Takaoka Yoshikazu; Tamamura Hirokazu; Fujii Nobutaka; Mitsuya Hiroaki
Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs.
Antimicrobial agents and chemotherapy 2008;52(6):2111-9.
2008: Horikawa Kentaro; Kudo Hironori; Ishihara Sonoko; Miyakawa Toshikazu; Kawaguchi Tatsuya; Mitsuya Hiroaki
[Aspergillosis of masticator space including mandibular bone responding to itraconazole treatment in a diabetic adult: case report]
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 2008;82(3):220-3.
2008: Nakamura Miki; Esumi Hiroyasu; Jin Lu; Mitsuya Hiroaki; Hata Hiroyuki
Induction of necrosis in human myeloma cells by kigamicin.
Anticancer research 2008;28(1A):37-43.
2008: Ghosh Arun K; Chapsal Bruno D; Weber Irene T; Mitsuya Hiroaki
Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.
Accounts of chemical research 2008;41(1):78-86.
2008: Kawamoto Atsushi; Kodama Eiichi; Sarafianos Stefan G; Sakagami Yasuko; Kohgo Satoru; Kitano Kenji; Ashida Noriyuki; Iwai Yuko; Hayakawa Hiroyuki; Nakata Hirotomo; Mitsuya Hiroaki; Arnold Eddy; Matsuoka Masao
2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants.
The international journal of biochemistry & cell biology 2008;40(11):2410-20.
2008: Mitsuya Hiroaki; Maeda Kenji; Das Debananda; Ghosh Arun K
Development of protease inhibitors and the fight with drug-resistant HIV-1 variants.
Advances in pharmacology (San Diego, Calif.) 2008;56():169-97.
2007: Ghosh Arun K; Dawson Zachary L; Mitsuya Hiroaki
Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV.
Bioorganic & medicinal chemistry 2007;15(24):7576-80.
2007: Koh Yasuhiro; Matsumi Shintaro; Das Debananda; Amano Masayuki; Davis David A; Li Jianfeng; Leschenko Sofiya; Baldridge Abigail; Shioda Tatsuo; Yarchoan Robert; Ghosh Arun K; Mitsuya Hiroaki
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.
The Journal of biological chemistry 2007;282(39):28709-20.
2007: Maeda Kenji; Mitsuya Hiroaki
Development of therapeutics for AIDS: structure-based molecular targeting.
Tuberculosis (Edinburgh, Scotland) 2007;87 Suppl 1():S31-4.
2007: Nakata Hirotomo; Amano Masayuki; Koh Yasuhiro; Kodama Eiichi; Yang Guangwei; Bailey Christopher M; Kohgo Satoru; Hayakawa Hiroyuki; Matsuoka Masao; Anderson Karen S; Cheng Yung-Chi; Mitsuya Hiroaki
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
Antimicrobial agents and chemotherapy 2007;51(8):2701-8.
2007: Harada Shigeyoshi; Hazra Rohan; Tamiya Sadahiro; Zeichner Steven L; Mitsuya Hiroaki
Emergence of human immunodeficiency virus type 1 variants containing the Q151M complex in children receiving long-term antiretroviral chemotherapy.
Antiviral research 2007;75(2):159-66.
2007: Asou Norio; Izuno Yoshiharu; Okubo Toshiya; Ide Kazuhiko; Ueno Hiroshi; Kawakita Makoto; Mitsuya Hiroaki; Hata Hiroyuki
Oral melphalan, dexamethasone, and thalidomide for the treatment of refractory multiple myeloma.
International journal of hematology 2007;86(1):69-71.
2007: Tatetsu Hiro; Ueno Shikiko; Hata Hiroyuki; Yamada Yasuhiro; Takeya Motohiro; Mitsuya Hiroaki; Tenen Daniel G; Okuno Yutaka
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.
Cancer research 2007;67(11):5328-36.
2007: Amano Masayuki; Koh Yasuhiro; Das Debananda; Li Jianfeng; Leschenko Sofiya; Wang Yuan-Fang; Boross Peter I; Weber Irene T; Ghosh Arun K; Mitsuya Hiroaki
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.
Antimicrobial agents and chemotherapy 2007;51(6):2143-55.
2007: Mitchell Michael S; Bodine Ellen T; Hill Shawn; Princler Gerald; Lloyd Patricia; Mitsuya Hiroaki; Matsuoka Masao; Derse David
Phenotypic and genotypic comparisons of human T-cell leukemia virus type 1 reverse transcriptases from infected T-cell lines and patient samples.
Journal of virology 2007;81(9):4422-8.
2007: Asou Norio; Yanagida Masatoshi; Huang Liqun; Yamamoto Masayuki; Shigesada Katsuya; Mitsuya Hiroaki; Ito Yoshiaki; Osato Motomi
Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia.
Blood 2007;109(9):4023-7.
2007: Nishizawa Rena; Nishiyama Toshihiko; Hisaichi Katsuya; Matsunaga Naoki; Minamoto Chiaki; Habashita Hiromu; Takaoka Yoshikazu; Toda Masaaki; Shibayama Shiro; Tada Hideaki; Sagawa Kenji; Fukushima Daikichi; Maeda Kenji; Mitsuya Hiroaki
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.
Bioorganic & medicinal chemistry letters 2007;17(3):727-31.
2007: Ohrui Hiroshi; Kohgo Satoru; Hayakawa Hiroyuki; Kodama Eiichi; Matsuoka Masao; Nakata Tomohiro; Mitsuya Hiroaki
2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1543-6.
2006: Depboylu Candan; Eiden Lee E; Schäfer Martin K-H; Reinhart Todd A; Mitsuya Hiroaki; Schall Thomas J; Weihe Eberhard
Fractalkine expression in the rhesus monkey brain during lentivirus infection and its control by 6-chloro-2',3'-dideoxyguanosine.
Journal of neuropathology and experimental neurology 2006;65(12):1170-80.
2006: Miyazato Paola; Yasunaga Jun-ichirou; Taniguchi Yuko; Koyanagi Yoshio; Mitsuya Hiroaki; Matsuoka Masao
De novo human T-cell leukemia virus type 1 infection of human lymphocytes in NOD-SCID, common gamma-chain knockout mice.
Journal of virology 2006;80(21):10683-91.
2006: Davis David A; Brown Cara A; Singer Kathleen E; Wang Victoria; Kaufman Joshua; Stahl Stephen J; Wingfield Paul; Maeda Kenji; Harada Shigeyoshi; Yoshimura Kazuhisa; Kosalaraksa Pope; Mitsuya Hiroaki; Yarchoan Robert
Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.
Antiviral research 2006;72(2):89-99.
2006: Yoshimura Kazuhisa; Shibata Junji; Kimura Tetsuya; Honda Akiko; Maeda Yosuke; Koito Atsushi; Murakami Toshio; Mitsuya Hiroaki; Matsushita Shuzo
Resistance profile of a neutralizing anti-HIV monoclonal antibody, KD-247, that shows favourable synergism with anti-CCR5 inhibitors.
AIDS (London, England) 2006;20(16):2065-73.
2006: Zhou Shaoman; Kern Earl R; Gullen Elizabeth; Cheng Yung-Chi; Drach John C; Tamiya Sadahiro; Mitsuya Hiroaki; Zemlicka Jiri
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Journal of medicinal chemistry 2006;49(20):6120-8.
2006: Mitsuya Hiroaki
[Progress in AIDS therapy]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2006;95(9):1845-50.
2006: Ghosh Arun K; Ramu Sridhar Perali; Kumaragurubaran Nagaswamy; Koh Yasuhiro; Weber Irene T; Mitsuya Hiroaki
Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance.
ChemMedChem 2006;1(9):939-50.
2006: Ghosh Arun K; Sridhar Perali Ramu; Leshchenko Sofiya; Hussain Azhar K; Li Jianfeng; Kovalevsky Andrey Yu; Walters D Eric; Wedekind Joseph E; Grum-Tokars Valerie; Das Debananda; Koh Yasuhiro; Maeda Kenji; Gatanaga Hiroyuki; Weber Irene T; Mitsuya Hiroaki
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.
Journal of medicinal chemistry 2006;49(17):5252-61.
2006: Yin P D; Das D; Mitsuya H
Overcoming HIV drug resistance through rational drug design based on molecular, biochemical, and structural profiles of HIV resistance.
Cellular and molecular life sciences : CMLS 2006;63(15):1706-24.
2006: Habashita Hiromu; Kokubo Masaya; Hamano Shin-ichi; Hamanaka Nobuyuki; Toda Masaaki; Shibayama Shiro; Tada Hideaki; Sagawa Kenji; Fukushima Daikichi; Maeda Kenji; Mitsuya Hiroaki
Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.
Journal of medicinal chemistry 2006;49(14):4140-52.
2006: Tatetsu Hiro; Asou Norio; Nakamura Miki; Hanaoka Nobuyoshi; Matsuno Fumihiko; Horikawa Kentaro; Mitsuya Hiroaki
Torsades de pointes upon fluconazole administration in a patient with acute myeloblastic leukemia.
American journal of hematology 2006;81(5):366-9.
2006: Maeda Kenji; Das Debananda; Ogata-Aoki Hiromi; Nakata Hirotomo; Miyakawa Toshikazu; Tojo Yasushi; Norman Rachael; Takaoka Yoshikazu; Ding Jianping; Arnold Gail F; Arnold Eddy; Mitsuya Hiroaki
Structural and molecular interactions of CCR5 inhibitors with CCR5.
The Journal of biological chemistry 2006;281(18):12688-98.
2006: Ghosh Arun K; Schiltz Gary; Perali Ramu Sridhar; Leshchenko Sofiya; Kay Stephanie; Walters D Eric; Koh Yasuhiro; Maeda Kenji; Mitsuya Hiroaki
Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.
Bioorganic & medicinal chemistry letters 2006;16(7):1869-73.
2006: Nakamura Miki; Gotoh Tomomi; Okuno Yutaka; Tatetsu Hiro; Sonoki Takashi; Uneda Shima; Mori Masataka; Mitsuya Hiroaki; Hata Hiroyuki
Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells.
Leukemia & lymphoma 2006;47(3):531-9.
2006: Hanaoka Nobuyoshi; Kawaguchi Tatsuya; Horikawa Kentaro; Nagakura Shoichi; Mitsuya Hiroaki; Nakakuma Hideki
Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP.
Blood 2006;107(3):1184-91.
2006: Yamada Yasuhiro; Nishimoto Eishi; Mitsuya Hiroaki; Yonemura Yuji
In vitro transdifferentiation of adult bone marrow Sca-1+ cKit- cells cocultured with fetal liver cells into hepatic-like cells without fusion.
Experimental hematology 2006;34(1):97-106.
2006: Gatanaga Hiroyuki; Das Debananda; Suzuki Yasuhiro; Yeh Damaris D; Hussain Khaja A; Ghosh Arun K; Mitsuya Hiroaki
Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop.
The Journal of biological chemistry 2006;281(2):1241-50.
2006: Ohrui Hiroshi; Kohgo Satoru; Hayakawa Hiroyuki; Kodama Eiichi; Matsuoka Masao; Nakata Tomohiro; Mitsuya Hiroyuki
2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.
Nucleic acids symposium series (2004) 2006;(50):1-2.
2005: Yonemura Yuji; Miyake Hirosada; Asou Norio; Mitsuya Hiroaki
Long-term efficacy of pegylated recombinant human megakaryocyte growth and development factor in therapy of aplastic anemia.
International journal of hematology 2005;82(4):307-9.
2005: Sonoki T; Iwanaga E; Mitsuya H; Asou N
Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(11):2009-10.
2005: Depboylu Candan; Schäfer Martin K-H; Schwaeble Wilhelm J; Reinhart Todd A; Maeda Hitomi; Mitsuya Hiroaki; Damadzic Ruslan; Rausch Dianne M; Eiden Lee E; Weihe Eberhard
Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2',3'-dideoxyguanosine.
Neurobiology of disease 2005;20(1):12-26.
2005: Sonoki Takashi; Iwanaga Eisaku; Mitsuya Hiroaki; Asou Norio
Ovarian relapse seven years after bone marrow transplantation for B-cell acute lymphoblastic leukemia: an unusual Krukenberg tumor.
American journal of hematology 2005;80(1):75-6.
2005: Nanri T; Matsuno N; Kawakita T; Mitsuya H; Asou N
Imatinib mesylate for refractory acute myeloblastic leukemia harboring inv(16) and a C-KIT exon 8 mutation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(9):1673-5.
2005: Nanri T; Matsuno N; Kawakita T; Suzushima H; Kawano F; Mitsuya H; Asou N
Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(8):1361-6.
2005: Tatetsu Hiro; Okuno Yutaka; Nakamura Miki; Matsuno Fumihiko; Sonoki Takashi; Taniguchi Izumi; Uneda Shima; Umezawa Kazuo; Mitsuya Hiroaki; Hata Hiroyuki
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, induces apoptosis in multiple myeloma cells in an IkappaBalpha-independent manner.
Molecular cancer therapeutics 2005;4(7):1114-20.
2005: Matsushita Shuzo; Yoshimura Kazuhisa; Kimura Tetsuya; Kamihira Asako; Takano Misao; Eto Kenichiro; Shirasaka Takuma; Mitsuya Hiroaki; Oka Shinichi
Spontaneous recovery of hemoglobin and neutrophil levels in Japanese patients on a long-term Combivir containing regimen.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;33(3):188-93.
2005: Ghosh Arun K; Swanson Lisa M; Cho Hanna; Leshchenko Sofiya; Hussain Khaja Azhar; Kay Stephanie; Walters D Eric; Koh Yasuhiro; Mitsuya Hiroaki
Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
Journal of medicinal chemistry 2005;48(10):3576-85.
2005: Matsuno Naofumi; Hoshino Koyu; Nanri Tomoko; Kawakita Toshiro; Suzushima Hitoshi; Kawano Fumio; Mitsuya Hiroaki; Asou Norio
p15 mRNA expression detected by real-time quantitative reverse transcriptase-polymerase chain reaction correlates with the methylation density of the gene in adult acute leukemia.
Leukemia research 2005;29(5):557-64.
2005: Matsuno N; Nanri T; Kawakita T; Mitsuya H; Asou N
A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(3):480-1.
2005: Nakata Hirotomo; Maeda Kenji; Miyakawa Toshikazu; Shibayama Shiro; Matsuo Masayoshi; Takaoka Yoshikazu; Ito Mamoru; Koyanagi Yoshio; Mitsuya Hiroaki
Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model.
Journal of virology 2005;79(4):2087-96.
2004: Zhou Shaoman; Kern Earl R; Gullen Elizabeth; Cheng Yung-Chi; Drach John C; Matsumi Shintaro; Mitsuya Hiroaki; Zemlicka Jiri
(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.
Journal of medicinal chemistry 2004;47(27):6964-72.
2004: Siddiqui Maqbool A; Hughes Stephen H; Boyer Paul L; Mitsuya Hiroaki; Van Que N; George Clifford; Sarafinanos Stefan G; Marquez Victor E
A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides.
Journal of medicinal chemistry 2004;47(21):5041-8.
2004: Maeda Kenji; Nakata Hirotomo; Ogata Hiromi; Koh Yasuhiro; Miyakawa Toshikazu; Mitsuya Hiroaki
The current status of, and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection.
Current opinion in pharmacology 2004;4(5):447-52.
2004: Hachiya Atsuko; Gatanaga Hiroyuki; Kodama Eiichi; Ikeuchi Mieko; Matsuoka Masao; Harada Shigeyoshi; Mitsuya Hiroaki; Kimura Satoshi; Oka Shinichi
Novel patterns of nevirapine resistance-associated mutations of human immunodeficiency virus type 1 in treatment-naïve patients.
Virology 2004;327(2):215-24.
2004: Yasunaga Jun-Ichirou; Taniguchi Yuko; Nosaka Kisato; Yoshida Mika; Satou Yorifumi; Sakai Tatsunori; Mitsuya Hiroaki; Matsuoka Masao
Identification of aberrantly methylated genes in association with adult T-cell leukemia.
Cancer research 2004;64(17):6002-9.
2004: Maeda Kenji; Nakata Hirotomo; Koh Yasuhiro; Miyakawa Toshikazu; Ogata Hiromi; Takaoka Yoshikazu; Shibayama Shiro; Sagawa Kenji; Fukushima Daikichi; Moravek Joseph; Koyanagi Yoshio; Mitsuya Hiroaki
Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro.
Journal of virology 2004;78(16):8654-62.
2004: Hayakawa Hiroyuki; Kohgo Satoru; Kitano Kenji; Ashida Noriyuki; Kodama Eiichi; Mitsuya Hiroaki; Ohrui Hiroshi
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
Antiviral chemistry & chemotherapy 2004;15(4):169-87.
2004: Depboylu Candan; Reinhart Todd A; Takikawa Osamu; Imai Yoshinori; Maeda Hitomi; Mitsuya Hiroaki; Rausch Dianne; Eiden Lee E; Weihe Eberhard
Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosine.
The European journal of neuroscience 2004;19(11):2997-3005.
2004: Matsuno N; Hoshino K; Nanri T; Kawakita T; Mitsuya H; Asou N
Transcriptional repression of the p15 gene predicts the clinical outcome of acute myeloblastic leukemia with intermediate and adverse cytogenetics.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(6):1146-8.
2004: Kitano Kenji; Kohgo Satoru; Yamada Kohei; Sakata Shinji; Ashida Noriyuki; Hayakawa Hiroyuki; Nameki Daisuke; Kodama Eiichi; Matsuoka Masao; Mitsuya Hiroaki; Ohrui Hiroshi
Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV.
Antiviral chemistry & chemotherapy 2004;15(3):161-7.
2004: Yanada Reiko; Koh Yasuhiro; Nishimori Nobuaki; Matsumura Akira; Obika Shingo; Mitsuya Hiroaki; Fujii Nobutaka; Takemoto Yoshiji
Indium-mediated atom-transfer and reductive radical cyclizations of iodoalkynes: synthesis and biological evaluation of HIV-protease inhibitors.
The Journal of organic chemistry 2004;69(7):2417-22.
2004: Kohgo Satoru; Yamada Kohei; Kitano Kenji; Iwai Yuko; Sakata Shinji; Ashida Noriyuki; Hayakawa Hiroyuki; Nameki Daisuke; Kodama Eiichi; Matsuoka Masao; Mitsuya Hiroaki; Ohrui Hiroshi
Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides.
Nucleosides, nucleotides & nucleic acids 2004;23(4):671-90.
2003: Matsuno N; Osato M; Yamashita N; Yanagida M; Nanri T; Fukushima T; Motoji T; Kusumoto S; Towatari M; Suzuki R; Naoe T; Nishii K; Shigesada K; Ohno R; Mitsuya H; Ito Y; Asou N
Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(12):2492-9.
2003: Mitsuya Hiroaki
[Multi-drug resistant pathogens, positioning of various drugs, and their appropriate use: 1. Anti-HIV agents]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(11):2170-81.
2003: Wang Ruifang; Harada Shigeyoshi; Mitsuya Hiroaki; Zemlicka Jiri
Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
Journal of medicinal chemistry 2003;46(22):4799-802.
2003: Koh Yasuhiro; Nakata Hirotomo; Maeda Kenji; Ogata Hiromi; Bilcer Geoffrey; Devasamudram Thippeswamy; Kincaid John F; Boross Peter; Wang Yuan-Fang; Tie Yunfeng; Volarath Patra; Gaddis Laquasha; Harrison Robert W; Weber Irene T; Ghosh Arun K; Mitsuya Hiroaki
Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.
Antimicrobial agents and chemotherapy 2003;47(10):3123-9.
2003: Yoshimura Kazuhisa; Ido Eiji; Akiyama Hisashi; Kimura Tetsuya; Aoki Manabu; Suzuki Hajime; Mitsuya Hiroaki; Hayami Masanori; Matsushita Shuzo
The impact of highly active antiretroviral therapy by the oral route on the CD8 subset in monkeys infected chronically with SHIV 89.6P.
Journal of virological methods 2003;112(1-2):121-8.
2003: Tatetsu Hiro; Asou Norio; Nakamura Miki; Koh Yasuhiro; Tajiri Tetsuya; Matsuno Fumihiko; Horikawa Kentaro; Yonemura Yuji; Mitsuya Hiroaki
[Allergic reaction against an emulsifier, HCO-60, contained in multamin and enocitabine]
[Rinsho ketsueki] The Japanese journal of clinical hematology 2003;44(7):471-3.
2003: Choi Yongseok; George Clifford; Comin Maria J; Barchi Joseph J; Kim Hak Sung; Jacobson Kenneth A; Balzarini Jan; Mitsuya Hiroaki; Boyer Paul L; Hughes Stephen H; Marquez Victor E
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
Journal of medicinal chemistry 2003;46(15):3292-9.
2003: Little Richard F; Pittaluga Stefania; Grant Nicole; Steinberg Seth M; Kavlick Mark F; Mitsuya Hiroaki; Franchini Genoveffa; Gutierrez Martin; Raffeld Mark; Jaffe Elaine S; Shearer Gene; Yarchoan Robert; Wilson Wyndham H
Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology.
Blood 2003;101(12):4653-9.
2003: Kohgo Satoru; Yamada Kohei; Kitano Kenji; Sakata Shinji; Hayakawa Hiroyuki; Nameki Daisuke; Kodama Eiichi; Matsuoka Masao; Mitsuya Hiroaki; Ohrui Hiroshi
Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):887-9.
2003: Matsumi Shintaro; Kosalaraksa Pope; Tsang Hsinyi; Kavlick Mark F; Harada Shigeyoshi; Mitsuya Hiroaki
Pathways for the emergence of multi-dideoxynucleoside-resistant HIV-1 variants.
AIDS (London, England) 2003;17(8):1127-37.
2003: Tamamura Hirokazu; Koh Yasuhiro; Ueda Satoshi; Sasaki Yoshikazu; Yamasaki Tomonori; Aoki Manabu; Maeda Kenji; Watai Yoriko; Arikuni Hisashi; Otaka Akira; Mitsuya Hiroaki; Fujii Nobutaka
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.
Journal of medicinal chemistry 2003;46(9):1764-8.
2003: Kawamura Tatsuyoshi; Gatanaga Hiroyuki; Borris Debra L; Connors Mark; Mitsuya Hiroaki; Blauvelt Andrew
Decreased stimulation of CD4+ T cell proliferation and IL-2 production by highly enriched populations of HIV-infected dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4260-6.
2003: Chen Xinchao; Matsumi Shintaro; Mitsuya Hiroaki; Zemlickal Jiri
Synthesis of (Z)-(2,3-bis-hydroxymethyl)methylenecyclopropane analogues of purine nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(3):265-74.
2003: Mitsuya Hiroaki
[HIV-1 infection and its treatment]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(3):502-7.
2003: Uneda Shima; Hata Hiroyuki; Matsuno Fumihiko; Nagasaki Akitoshi; Harada Naoko; Mitsuya Yumi; Matsuzaki Hiromitsu; Mitsuya Hiroaki
A nitric oxide synthase inhibitor, N(G)-nitro-l-arginine-methyl-ester, exerts potent antiangiogenic effects on plasmacytoma in a newly established multiple myeloma severe combined immunodeficient mouse model.
British journal of haematology 2003;120(3):396-404.
2003: Uneda Shima; Hata Hiroyuki; Matsuno Fumihiko; Harada Naoko; Mitsuya Yumi; Kawano Fumio; Mitsuya Hiroaki
Macrophage inflammatory protein-1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM.
British journal of haematology 2003;120(1):53-5.
2002: Wang Ruifang; Corbett Thomas H; Cheng Yung-Chi; Drach John C; Kern Earl R; Mitsuya Hiroaki; Zemlicka Jiri
Tryptophanyl phosphoramidates as prodrugs of synadenol and its E-isomer: synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2002;12(17):2467-70.
2002: Nagakura Shoichi; Ishihara Sonoko; Dunn Daniel E; Nishimura Jun-ichi; Kawaguchi Tatsuya; Horikawa Kentaro; Hidaka Michihiro; Kagimoto Tadashi; Eto Nozomu; Mitsuya Hiroaki; Kinoshita Taroh; Young Neal S; Nakakuma Hideki
Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro.
Blood 2002;100(3):1031-7.
2002: Hoshino Koyu; Asou Norio; Okubo Toshiya; Suzushima Hitoshi; Kiyokawa Tetsuyuki; Kawano Fumio; Mitsuya Hiroaki
The absence of the p15INK4B gene alterations in adult patients with precursor B-cell acute lymphoblastic leukaemia is a favourable prognostic factor.
British journal of haematology 2002;117(3):531-40.
2002: Nakata Hirotomo; Mitsuya Hiroaki
[The current status of structured treatment interruption]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(4):807-12.
2002: Mitsuya Hiroaki
[Understanding of AIDS and its control]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(4):641-5.
2002: Kudo Hironori; Matsuoka Takako; Mitsuya Hiroaki; Nishimura Yasuharu; Matsushita Sho
Cross-linking HLA-DR molecules on Th1 cells induces anergy in association with increased level of cyclin-dependent kinase inhibitor p27(Kip1).
Immunology letters 2002;81(2):149-55.
2002: Iga Mutsunori; Okayama Akihiko; Stuver Sherri; Matsuoka Masao; Mueller Nancy; Aoki Manabu; Mitsuya Hiroaki; Tachibana Nobuyoshi; Tsubouchi Hirohito
Genetic evidence of transmission of human T cell lymphotropic virus type 1 between spouses.
The Journal of infectious diseases 2002;185(5):691-5.
2002: Yoshimura Kazuhisa; Kato Ryohei; Kavlick Mark F; Nguyen Aline; Maroun Victor; Maeda Kenji; Hussain Khaja A; Ghosh Arun K; Gulnik Sergei V; Erickson John W; Mitsuya Hiroaki
A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.
Journal of virology 2002;76(3):1349-58.
2002: Gatanaga Hiroyuki; Suzuki Yasuhiro; Tsang Hsinyi; Yoshimura Kazuhisa; Kavlick Mark F; Nagashima Kunio; Gorelick Robert J; Mardy Sek; Tang Chun; Summers Michael F; Mitsuya Hiroaki
Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors.
The Journal of biological chemistry 2002;277(8):5952-61.
2002: Miyakawa Toshikazu; Obaru Kenshi; Maeda Kenji; Harada Shigeyoshi; Mitsuya Hiroaki
Identification of amino acid residues critical for LD78beta, a variant of human macrophage inflammatory protein-1alpha, binding to CCR5 and inhibition of R5 human immunodeficiency virus type 1 replication.
The Journal of biological chemistry 2002;277(7):4649-55.
2002: Nosaka Kisato; Miyamoto Takeshi; Sakai Tatsunori; Mitsuya Hiroaki; Suda Toshio; Matsuoka Masao
Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells.
Blood 2002;99(2):634-40.
2002: Horikawa Kentaro; Kawaguchi Tatsuya; Ishihara Sonoko; Nagakura Shoichi; Hidaka Michihiro; Kagimoto Tadashi; Mitsuya Hiroaki; Nakakuma Hideki
Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria.
Blood 2002;99(1):24-9.
2002: Egron David; Périgaud Christian; Gosselin Gilles; Aubertin Anne-Marie; Gatanaga Hiroyuki; Mitsuya Hiroaki; Zemlicka Jiri; Imbach Jean-Louis
Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative.
Bioorganic & medicinal chemistry letters 2002;12(2):265-6.
2001: Nakata H; Mitsuya H
[Severe combined immunodeficiency disease and similar combined immunodeficiency disease]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 7():581-7.
2001: Suzuki Y; Rahman M; Mitsuya H
Diverse transcriptional response of CD4(+) T cells to stromal cell-derived factor (SDF)-1: cell survival promotion and priming effects of SDF-1 on CD4(+) T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3064-73.
2001: Maeda K; Yoshimura K; Shibayama S; Habashita H; Tada H; Sagawa K; Miyakawa T; Aoki M; Fukushima D; Mitsuya H
Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.
The Journal of biological chemistry 2001;276(37):35194-200.
2001: Kohgo S; Mitsuya H; Ohrui H
Synthesis of the L-enantiomer of 4'-C-ethynyl-2'-deoxycytidine.
Bioscience, biotechnology, and biochemistry 2001;65(8):1879-82.
2001: Ohrui H; Mitsuya H
4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants.
Current drug targets. Infectious disorders 2001;1(1):1-10.
2001: Yasunaga Ji; Sakai T; Nosaka K; Etoh Ki; Tamiya S; Koga S; Mita S; Uchino M; Mitsuya H; Matsuoka M
Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: its implications in the immunodeficient state.
Blood 2001;97(10):3177-83.
2001: Sakai T; Matsuoka M; Aoki M; Nosaka K; Mitsuya H
Missense mutation of the interleukin-12 receptor beta1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection.
Blood 2001;97(9):2688-94.
2001: Kodama E I; Kohgo S; Kitano K; Machida H; Gatanaga H; Shigeta S; Matsuoka M; Ohrui H; Mitsuya H
4'-Ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro.
Antimicrobial agents and chemotherapy 2001;45(5):1539-46.
2000: Ohrui H; Kohgo S; Kitano K; Sakata S; Kodama E; Yoshimura K; Matsuoka M; Shigeta S; Mitsuya H
Syntheses of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity.
Journal of medicinal chemistry 2000;43(23):4516-25.
2000: Pilon A A; Marchand C; Kavlick M F; Bajaj K; Owen J; Mitsuya H; Pommier Y
Mutations in the HIV type 1 integrase of patients receiving long-term dideoxynucleoside therapy do not confer resistance to zidovudine.
AIDS research and human retroviruses 2000;16(14):1417-22.
2000: Mitsuya H
[Molecular mechanisms for the emergence of drug-resistant HIV-1]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(12):1899-908.
2000: Mu L; Sarafianos S G; Nicklaus M C; Russ P; Siddiqui M A; Ford H; Mitsuya H; Le R; Kodama E; Meier C; Knispel T; Anderson L; Barchi J J; Marquez V E
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.
Biochemistry 2000;39(37):11205-15.
2000: Shah F S; Curr K A; Hamburgh M E; Parniak M; Mitsuya H; Arnez J G; Prasad V R
Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.
The Journal of biological chemistry 2000;275(35):27037-44.
2000: Ishihara S; Nakakuma H; Kawaguchi T; Nagakura S; Horikawa K; Hidaka M; Asou N; Mitsuya H
Two cases showing clonal progression with full evolution from aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome to myelodysplastic syndromes and leukemia.
International journal of hematology 2000;72(2):206-9.
2000: Li K; Kawaguchi T; Ishihara S; Horikawa K; Hidaka M; Sakaguchi M; Tsuruzaki R; Kawakita M; Kagimoto T; Mitsuya H; Nakakuma H
Rarity of microsatellite alterations in patients with paroxysmal nocturnal haemoglobinuria.
European journal of haematology 2000;64(6):430-2.
2000: Kudo H; Senju S; Mitsuya H; Nishimura Y
Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase.
Biochemical and biophysical research communications 2000;272(2):456-65.
2000: Sei S; Yang Q E; O'Neill D; Yoshimura K; Nagashima K; Mitsuya H
Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain.
Journal of virology 2000;74(10):4621-33.
2000: Ishihara S; Horikawa K; Kawaguchi T; Ke L; Hidaka M; Nagakura S; Mitsuya H; Sendo F; Nakakuma H
3H9, a monoclonal antibody capable of discriminating neutrophilic from basophilic and eosinophilic granulocytes.
European journal of haematology 2000;64(4):275-6.
2000: Ito H; Matsushita S; Tokano Y; Nishimura H; Tanaka Y; Fujisao S; Mitsuya H; Hashimoto H; Nishimura Y
Analysis of T cell responses to the beta 2-glycoprotein I-derived peptide library in patients with anti-beta 2-glycoprotein I antibody-associated autoimmunity.
Human immunology 2000;61(4):366-77.
2000: Nosaka K; Maeda M; Tamiya S; Sakai T; Mitsuya H; Matsuoka M
Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia.
Cancer research 2000;60(4):1043-8.
2000: Falloon J; Piscitelli S; Vogel S; Sadler B; Mitsuya H; Kavlick M F; Yoshimura K; Rogers M; LaFon S; Manion D J; Lane H C; Masur H
Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;30(2):313-8.
2000: Kodama E N; McCaffrey R P; Yusa K; Mitsuya H
Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells.
Biochemical pharmacology 2000;59(3):273-81.
2000: Gao W Y; Johns D G; Mitsuya H
Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):371-7.
2000: Kawaguchi T; Koga S; Hongo H; Komiyama Y; Li K; Ishihara S; Horikawa K; Hidaka M; Mitsuya H; Nakakuma H
A novel type of factor XI deficiency showing compound genetic abnormalities: a nonsense mutation and an impaired transcription.
International journal of hematology 2000;71(1):84-9.
2000: Shimomura T; Yonemura Y; Miyazoe T; Miyake H; Kato T; Miyazaki H; Mitsuya H; Kawakita M
Thrombopoietin stimulates murine lineage negative, Sca-1+, C-Kit+, CD34- cells: comparative study with stem cell factor or interleukin-3.
International journal of hematology 2000;71(1):33-9.
2000: Asou N; Suzushima H; Nishimura S; Okubo T; Yamasaki H; Osato M; Hoshino K; Takatsuki K; Mitsuya H
Long-term remission in an elderly patient with mantle cell leukemia treated with low-dose cyclophosphamide.
American journal of hematology 2000;63(1):35-7.
2000: Kitano K; Sakata S; Kohgo S; Matsuoka M; Kodama E; Mitsuya H; Ohrui H
Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity.
Nucleic acids symposium series 2000;(44):105-6.
2000: Harada N; Nagasaki A; Hata H; Matsuzaki H; Matsuno F; Mitsuya H
Down-regulation of CD98 in melphalan-resistant myeloma cells with reduced drug uptake.
Acta haematologica 2000;103(3):144-51.
1999: Fujiwara M; Kodama E N; Okamoto M; Tokuhisa K; Ide T; Hanasaki Y; Katsuura K; Takayama H; Aimi N; Mitsuya H; Shigeta S; Konno K; Yokota T; Baba M
Characterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217.
Antiviral chemistry & chemotherapy 1999;10(6):315-20.
1999: Yoshimura K; Feldman R; Kodama E; Kavlick M F; Qiu Y L; Zemlicka J; Mitsuya H
In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues.
Antimicrobial agents and chemotherapy 1999;43(10):2479-83.
1999: Harada N; Hata H; Matsuno F; Sonoki T; Kuribayashi N; Matsuzaki H; Mitsuya H
Absence of Kaposi's sarcoma-associated herpesvirus (KSHV) in bone marrow cells from Japanese myeloma patients.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(9):1465-6.
1999: Yoshimura K; Kato R; Yusa K; Kavlick M F; Maroun V; Nguyen A; Mimoto T; Ueno T; Shintani M; Falloon J; Masur H; Hayashi H; Erickson J; Mitsuya H
JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8675-80.
1999: Kosalaraksa P; Kavlick M F; Maroun V; Le R; Mitsuya H
Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an In vitro competitive HIV-1 replication assay.
Journal of virology 1999;73(7):5356-63.
1999: Uchida H; Kodama E N; Yoshimura K; Maeda Y; Kosalaraksa P; Maroun V; Qiu Y L; Zemlicka J; Mitsuya H
In vitro anti-human immunodeficiency virus activities of Z- and E-methylenecyclopropane nucleoside analogues and their phosphoro-L-alaninate diesters.
Antimicrobial agents and chemotherapy 1999;43(6):1487-90.
1999: Sonoki T; Matsuzaki H; Nagasaki A; Hata H; Yoshida M; Matsuoka M; Kuribayashi N; Kimura T; Harada N; Takatsuki K; Mitsuya H; Mori M
Detection of inducible nitric oxide synthase (iNOS) mRNA by RT-PCR in ATL patients and HTLV-I infected cell lines: clinical features and apoptosis by NOS inhibitor.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(5):713-8.
1999: Mitsuya H
[Recent challenges and progress in AIDS therapy--emergence of drug resistant HIV-1 variants]
[Rinsho ketsueki] The Japanese journal of clinical hematology 1999;40(4):249-54.
1999: Okamoto M; Fujiwara M; Kodama E; Yamamoto O; Shigeta S; Mitsuya H; Konno K; Yokota T; Baba M
Inhibition of human immunodeficiency virus replication by RD6-Y664, a novel benzylhydroxylamine derivative.
Antiviral chemistry & chemotherapy 1999;10(2):71-7.
1999: Sonoki T; Hata H; Kuribayashi N; Yoshida M; Harada N; Nagasaki A; Kimura T; Matsuno F; Mitsuya H; Matsuzaki H
Expression of PRAD1/cyclin D1 in plasma cell malignancy: incidence and prognostic aspects.
British journal of haematology 1999;104(3):614-7.
1999: Rabkin C S; Yang Q; Goedert J J; Nguyen G; Mitsuya H; Sei S
Chemokine and chemokine receptor gene variants and risk of non-Hodgkin's lymphoma in human immunodeficiency virus-1-infected individuals.
Blood 1999;93(6):1838-42.
1999: Gao W Y; Johns D G; Tanaka M; Mitsuya H
Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine.
Molecular pharmacology 1999;55(3):535-40.
1999: Humphrey R W; Wyvill K M; Nguyen B Y; Shay L E; Kohler D R; Steinberg S M; Ueno T; Fukasawa T; Shintani M; Hayashi H; Mitsuya H; Yarchoan R
A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection.
Antiviral research 1999;41(1):21-33.
1999: Davis D A; Yusa K; Gillim L A; Newcomb F M; Mitsuya H; Yarchoan R
Conserved cysteines of the human immunodeficiency virus type 1 protease are involved in regulation of polyprotein processing and viral maturation of immature virions.
Journal of virology 1999;73(2):1156-64.
1999: Sonoki T; Matsuzaki H; Satterwhite E; Nakazawa N; Hata H; Tucker P W; Taniwaki M; Kuribayashi N; Harada N; Matsuno F; Mitsuya H
A plasma cell leukemia patient showing bialleic 14q translocations: t(2;14) and t(11;14).
Acta haematologica 1999;101(4):197-201.
1998: Sonoki T; Nakazawa N; Hata H; Taniwaki M; Nagasaki A; Seto M; Yoshida M; Kuribayashi N; Kimura T; Harada N; Mitsuya H; Matsuzaki H
Amplification and overexpression of the PRAD1/Cyclin D1 gene in a multiple myeloma cell line.
International journal of hematology 1998;68(4):459-61.
1998: Harada N; Hata H; Yoshida M; Soniki T; Nagasaki A; Kuribayashi N; Kimura T; Matsuzaki H; Mitsuya H
Expression of Bcl-2 family of proteins in fresh myeloma cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(11):1817-20.
1998: Roth J S; Ford H; Tanaka M; Mitsuya H; Kelley J A
Determination of 2'-beta-fluoro-2',3'-dideoxyadenosine, an experimental anti-AIDS drug, in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1998;712(1-2):199-210.
1998: Gao W Y; Zhou B S; Johns D G; Mitsuya H; Yen Y
Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2',3'-dideoxyinosine.
Biochemical pharmacology 1998;56(1):105-12.
1998: Mueller B U; Anderson B D; Farley M Q; Murphy R; Zuckerman J; Jarosinski P; Godwin K; McCully C L; Mitsuya H; Pizzo P A; Balis F M
Pharmacokinetics of the protease inhibitor KNI-272 in plasma and cerebrospinal fluid in nonhuman primates after intravenous dosing and in human immunodeficiency virus-infected children after intravenous and oral dosing.
Antimicrobial agents and chemotherapy 1998;42(7):1815-8.
1998: Kavlick M F; Wyvill K; Yarchoan R; Mitsuya H
Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy.
The Journal of infectious diseases 1998;177(6):1506-13.
1998: Maeda Y; Venzon D J; Mitsuya H
Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance.
The Journal of infectious diseases 1998;177(5):1207-13.
1998: Rezende L F; Curr K; Ueno T; Mitsuya H; Prasad V R
The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity.
Journal of virology 1998;72(4):2890-5.
1998: Obaru K; Mitsuya H
[Anti-HIV drugs and drug delivery system]
Nippon rinsho. Japanese journal of clinical medicine 1998;56(3):769-75.
1997: Mitsuya H
[Chemotherapy of AIDS--recent progress]
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 1997;20(6):465-70.
1997: Yusa K; Kavlick M F; Kosalaraksa P; Mitsuya H
HIV-1 acquires resistance to two classes of antiviral drugs through homologous recombination.
Antiviral research 1997;36(3):179-89.
1997: Uchida H; Maeda Y; Mitsuya H
HIV-1 protease does not play a critical role in the early stages of HIV-1 infection.
Antiviral research 1997;36(2):107-13.
1997: Winter H; Maeda Y; Uchida H; Mitsuya H; Zemlicka J
Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity.
Journal of medicinal chemistry 1997;40(14):2191-5.
1997: Tanaka M; Srinivas R V; Ueno T; Kavlick M F; Hui F K; Fridland A; Driscoll J S; Mitsuya H
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine.
Antimicrobial agents and chemotherapy 1997;41(6):1313-8.
1997: Humphrey R W; Ohagen A; Davis D A; Fukazawa T; Hayashi H; Höglund S; Mitsuya H; Yarchoan R
Removal of human immunodeficiency virus type 1 (HIV-1) protease inhibitors from preparations of immature HIV-1 virions does not result in an increase in infectivity or the appearance of mature morphology.
Antimicrobial agents and chemotherapy 1997;41(5):1017-23.
1997: Mitsuya H
Telling the truth to cancer patients and patients with HIV-1 infection in Japan.
Annals of the New York Academy of Sciences 1997;809():279-89.
1997: Ueno T; Mitsuya H
Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay.
Biochemistry 1997;36(5):1092-9.
1997: Brouwers P; Hendricks M; Lietzau J A; Pluda J M; Mitsuya H; Broder S; Yarchoan R
Effect of combination therapy with zidovudine and didanosine on neuropsychological functioning in patients with symptomatic HIV disease: a comparison of simultaneous and alternating regimens.
AIDS (London, England) 1997;11(1):59-66.
1996: Foli A; Sogocio K M; Anderson B; Kavlick M; Saville M W; Wainberg M A; Gu Z; Cherrington J M; Mitsuya H; Yarchoan R
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Antiviral research 1996;32(2):91-8.
1996: Winter H; Maeda Y; Mitsuya H; Zemlicka J
Phosphodiester amidates of allenic nucleoside analogues: anti-HIV activity and possible mechanism of action.
Journal of medicinal chemistry 1996;39(17):3300-6.
1996: Ahluwalia G S; Gao W Y; Mitsuya H; Johns D G
2',3'-Didehydro-3'-deoxythymidine: regulation of its metabolic activation by modulators of thymidine-5'-triphosphate biosynthesis.
Molecular pharmacology 1996;50(1):160-5.
1996: Driscoll J S; Siddiqui M A; Ford H; Kelley J A; Roth J S; Mitsuya H; Tanaka M; Marquez V E
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-Amino prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
Journal of medicinal chemistry 1996;39(8):1619-25.
1995: Shirasaka T; Chokekijchai S; Yamada A; Gosselin G; Imbach J L; Mitsuya H
Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells.
Antimicrobial agents and chemotherapy 1995;39(11):2555-9.
1995: Kavlick M F; Shirasaka T; Kojima E; Pluda J M; Hui F; Yarchoan R; Mitsuya H
Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (--)-2',3'-dideoxy-3'-thiacytidine.
Antiviral research 1995;28(2):133-46.
1995: Ueno T; Shirasaka T; Mitsuya H
Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates.
The Journal of biological chemistry 1995;270(40):23605-11.
1995: Chokekijchai S; Shirasaka T; Weinstein J N; Mitsuya H
In vitro anti-HIV-1 activity of HIV protease inhibitor KNI-272 in resting and activated cells: implications for its combined use with AZT or ddI.
Antiviral research 1995;28(1):25-38.
1995: Gao W Y; Johns D G; Chokekuchai S; Mitsuya H
Disparate actions of hydroxyurea in potentiation of purine and pyrimidine 2',3'-dideoxynucleoside activities against replication of human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8333-7.
1995: Gao W Y; Mitsuya H; Driscoll J S; Johns D G
Enhancement by hydroxyurea of the anti-human immunodeficiency virus type 1 potency of 2'-beta-fluoro-2',3'-dideoxyadenosine in peripheral blood mononuclear cells.
Biochemical pharmacology 1995;50(2):274-6.
1995: Baldwin E T; Bhat T N; Gulnik S; Liu B; Topol I A; Kiso Y; Mimoto T; Mitsuya H; Erickson J W
Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine.
Structure (London, England : 1993) 1995;3(6):581-90.
1995: Husson R N; Lan Y; Kojima E; Venzon D; Mitsuya H; McIntosh K
Vertical transmission of human immunodeficiency virus type 1: autologous neutralizing antibody, virus load, and virus phenotype.
The Journal of pediatrics 1995;126(6):865-71.
1995: Hawkins M E; Mitsuya H; McCully C M; Godwin K S; Murakami K; Poplack D G; Balis F M
Pharmacokinetics of dideoxypurine nucleoside analogs in plasma and cerebrospinal fluid of rhesus monkeys.
Antimicrobial agents and chemotherapy 1995;39(6):1259-64.
1995: Nguyen B Y; Yarchoan R; Wyvill K M; Venzon D J; Pluda J M; Mitsuya H; Broder S
Five-year follow-up of a phase I study of didanosine in patients with advanced human immunodeficiency virus infection.
The Journal of infectious diseases 1995;171(5):1180-9.
1995: Kojima E; Shirasaka T; Anderson B D; Chokekijchai S; Steinberg S M; Broder S; Yarchoan R; Mitsuya H
Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy.
The Journal of infectious diseases 1995;171(5):1152-8.
1995: Jones B C; Silverton J V; Simons C; Megati S; Nishimura H; Maeda Y; Mitsuya H; Zemlicka J
Synthesis, absolute configuration, and enantioselectivity of antiretroviral effect of (R)-(-)- and (S)-(+)-cytallene. Lipase-catalyzed enantioselective acylations of (+/-)-N4-acylcytallenes.
Journal of medicinal chemistry 1995;38(8):1397-405.
1995: Ford H; Siddiqui M A; Driscoll J S; Marquez V E; Kelley J A; Mitsuya H; Shirasaka T
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 2. 6-Halo and 6-alkoxy prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
Journal of medicinal chemistry 1995;38(7):1189-95.
1995: Xu Z Q; Qiu Y L; Chokekijchai S; Mitsuya H; Zemlicka J
Unsaturated acyclic analogues of 2'-deoxyadenosine and thymidine containing fluorine: synthesis and biological activity.
Journal of medicinal chemistry 1995;38(6):875-82.
1995: O'Brien M C; Ueno T; Jahan N; Zajac-Kaye M; Mitsuya H
HIV-1 expression induced by anti-cancer agents in latently HIV-1-infected ACH2 cells.
Biochemical and biophysical research communications 1995;207(3):903-9.
1995: Baldwin E T; Bhat T N; Gulnik S; Liu B; Kiso Y; Mitsuya H; Erickson J W
Structure of HIV-1 protease with KNI-272: a transition state mimetic inhibitor containing allophenylnorstatine.
Advances in experimental medicine and biology 1995;362():445-9.
1994: Anderson B D; Shirasaka T; Kojima E; Yarchoan R; Mitsuya H
Identification of drug-related genotypic changes in HIV-1 from serum using the selective polymerase chain reaction.
Antiviral research 1994;25(3-4):245-58.
1994: Ahluwalia G S; Cooney D A; Shirasaka T; Mitsuya H; Driscoll J S; Johns D G
Enhancement by 2'-deoxycoformycin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of 2',3'-dideoxyadenosine and 2'-beta-fluoro-2',3'-dideoxyadenosine.
Molecular pharmacology 1994;46(5):1002-8.
1994: Gao W Y; Johns D G; Mitsuya H
Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosides.
Molecular pharmacology 1994;46(4):767-72.
1994: Gao W Y; Johns D G; Mitsuya H
Enzymatic assay for quantification of deoxynucleoside triphosphates in human cells exposed to antiretroviral 2',3'-dideoxynucleosides.
Analytical biochemistry 1994;222(1):116-22.
1994: Rodriguez J B; Marquez V E; Nicklaus M C; Mitsuya H; Barchi J J
Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.
Journal of medicinal chemistry 1994;37(20):3389-99.
1994: Sei S; Kleiner D E; Kopp J B; Chandra R; Klotman P E; Yarchoan R; Pizzo P A; Mitsuya H
Quantitative analysis of viral burden in tissues from adults and children with symptomatic human immunodeficiency virus type 1 infection assessed by polymerase chain reaction.
The Journal of infectious diseases 1994;170(2):325-33.
1994: Kageyama S; Hoekzema D T; Murakawa Y; Kojima E; Shirasaka T; Kempf D J; Norbeck D W; Erickson J; Mitsuya H
A C2 symmetry-based HIV protease inhibitor, A77003, irreversibly inhibits infectivity of HIV-1 in vitro.
AIDS research and human retroviruses 1994;10(6):735-43.
1994: Kageyama S; Anderson B D; Hoesterey B L; Hayashi H; Kiso Y; Flora K P; Mitsuya H
Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins.
Antimicrobial agents and chemotherapy 1994;38(5):1107-11.
1994: Gao W Y; Agbaria R; Driscoll J S; Mitsuya H
Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2',3'-dideoxynucleoside analogs in resting and activated human cells.
The Journal of biological chemistry 1994;269(17):12633-8.
1994: Yarchoan R; Lietzau J A; Nguyen B Y; Brawley O W; Pluda J M; Saville M W; Wyvill K M; Steinberg S M; Agbaria R; Mitsuya H
A randomized pilot study of alternating or simultaneous zidovudine and didanosine therapy in patients with symptomatic human immunodeficiency virus infection.
The Journal of infectious diseases 1994;169(1):9-17.
1993: Kojima E; Shirasaka T; Anderson B; Chokekijchai S; Sei S; Yarchoan R; Mitsuya H
Monitoring the activity of antiviral therapy for HIV infection using a polymerase chain reaction method coupled with reverse transcription.
AIDS (London, England) 1993;7 Suppl 2():S101-5.
1993: Johns D G; Ahluwalia G S; Cooney D A; Mitsuya H; Driscoll J S
Enhanced stimulation by ribavirin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of purine 2'-beta-fluoro-2',3'-dideoxynucleosides.
Molecular pharmacology 1993;44(3):519-23.
1993: Husson R N; Shirasaka T; Butler K M; Pizzo P A; Mitsuya H
High-level resistance to zidovudine but not to zalcitabine or didanosine in human immunodeficiency virus from children receiving antiretroviral therapy.
The Journal of pediatrics 1993;123(1):9-16.
1993: Yarchoan R; Mitsuya H; Broder S
Challenges in the therapy of HIV infection.
Immunology today 1993;14(6):303-9.
1993: Gao W Y; Shirasaka T; Johns D G; Broder S; Mitsuya H
Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells.
The Journal of clinical investigation 1993;91(5):2326-33.
1993: Yarchoan R; Mitsuya H; Broder S
Challenges in the therapy of HIV infection.
Trends in pharmacological sciences 1993;14(5):196-202.
1993: Ahluwalia G; Cooney D A; Hartman N R; Mitsuya H; Yarchoan R; Fridland A; Broder S; Johns D G
Anomalous accumulation and decay of 2',3'-dideoxyadenosine-5'-triphosphate in human T-cell cultures exposed to the anti-HIV drug 2',3'-dideoxyinosine.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):369-76.
1993: Shirasaka T; Yarchoan R; O'Brien M C; Husson R N; Anderson B D; Kojima E; Shimada T; Broder S; Mitsuya H
Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):562-6.
1992: Megati S; Goren Z; Silverton J V; Orlina J; Nishimura H; Shirasaki T; Mitsuya H; Zemlicka J
(R)-(-)- and (S)-(+)-adenallene: synthesis, absolute configuration, enantioselectivity of antiretroviral effect, and enzymic deamination.
Journal of medicinal chemistry 1992;35(22):4098-104.
1992: Kelly K; Davis P; Mitsuya H; Irving S; Wright J; Grassmann R; Fleckenstein B; Wano Y; Greene W; Siebenlist U
A high proportion of early response genes are constitutively activated in T cells by HTLV-I.
Oncogene 1992;7(8):1463-70.
1992: Aoki-Sei S; Yarchoan R; Kageyama S; Hoekzema D T; Pluda J M; Wyvill K M; Broder S; Mitsuya H
Plasma HIV-1 viremia in HIV-1 infected individuals assessed by polymerase chain reaction.
AIDS research and human retroviruses 1992;8(7):1263-70.
1992: Yarchoan R; Mitsuya H; Broder S
The immunology of HIV infection: implications for therapy.
AIDS research and human retroviruses 1992;8(6):1023-31.
1992: Siddiqui M A; Driscoll J S; Marquez V E; Roth J S; Shirasaka T; Mitsuya H; Barchi J J; Kelley J A
Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines.
Journal of medicinal chemistry 1992;35(12):2195-201.
1992: Kageyama S; Weinstein J N; Shirasaka T; Kempf D J; Norbeck D W; Plattner J J; Erickson J; Mitsuya H
In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations.
Antimicrobial agents and chemotherapy 1992;36(5):926-33.
1991: Aoki-Sei S; O'Brien M C; Ford H; Fujii H; Gilbert D A; Cooney D A; Johns D G; Broder S; Mitsuya H
In vitro inhibition of hepatitis B virus replication by 2',3'-dideoxyguanosine, 2',3'-dideoxyinosine, and 3'-azido-2',3'-dideoxythymidine in 2.2.15 (PR) cells.
The Journal of infectious diseases 1991;164(5):843-51.
1991: Mitsuya H
[Inhibitors of HIV-1 reverse transcriptase and protease as chemotherapeutics for AIDS]
Nippon rinsho. Japanese journal of clinical medicine 1991;49(9):2062-9.
1991: Yarchoan R; Pluda J M; Perno C F; Mitsuya H; Broder S
Anti-retroviral therapy of human immunodeficiency virus infection: current strategies and challenges for the future.
Blood 1991;78(4):859-84.
1991: Mitsuya H; Yarchoan R; Kageyama S; Broder S
Targeted therapy of human immunodeficiency virus-related disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(10):2369-81.
1991: Hartman N R; Ahluwalia G S; Cooney D A; Mitsuya H; Kageyama S; Fridland A; Broder S; Johns D G
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.
Molecular pharmacology 1991;40(1):118-24.
1991: Barchi J J; Marquez V E; Driscoll J S; Ford H; Mitsuya H; Shirasaka T; Aoki S; Kelley J A
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs.
Journal of medicinal chemistry 1991;34(5):1647-55.
1991: Murakami K; Shirasaka T; Yoshioka H; Kojima E; Aoki S; Ford H; Driscoll J S; Kelley J A; Mitsuya H
Escherichia coli mediated biosynthesis and in vitro anti-HIV activity of lipophilic 6-halo-2',3'-dideoxypurine nucleosides.
Journal of medicinal chemistry 1991;34(5):1606-12.
1991: Pluda J M; Mitsuya H; Yarchoan R
Hematologic effects of AIDS therapies.
Hematology/oncology clinics of North America 1991;5(2):229-48.
1991: Tseng C K; Marquez V E; Milne G W; Wysocki R J; Mitsuya H; Shirasaki T; Driscoll J S
A ring-enlarged oxetanocin A analogue as an inhibitor of HIV infectivity.
Journal of medicinal chemistry 1991;34(1):343-9.
1991: Bondoc L L; Robbins B L; Ahluwalia G S; Mitsuya H; Johns D G; Fridland A
Modulation of metabolism and anti-HIV-1 activity of purine 2',3'-dideoxynucleosides by IMP dehydrogenase inhibitors.
Advances in experimental medicine and biology 1991;309A():49-53.
1991: Kojima E; Shirasaka T; Machida M; Yoshioka H; Murakami K; Mitsuya H
Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents.
Nucleic acids symposium series 1991;(25):91-2.
1990: Shirasaka T; Murakami K; Ford H; Kelley J A; Yoshioka H; Kojima E; Aoki S; Broder S; Mitsuya H
Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9426-30.
1990: Aoki S; Yarchoan R; Thomas R V; Pluda J M; Marczyk K; Broder S; Mitsuya H
Quantitative analysis of HIV-1 proviral DNA in peripheral blood mononuclear cells from patients with AIDS or ARC: decrease of proviral DNA content following treatment with 2',3'-dideoxyinosine (ddI).
AIDS research and human retroviruses 1990;6(11):1331-9.
1990: Broder S; Mitsuya H; Yarchoan R; Pavlakis G N
NIH conference. Antiretroviral therapy in AIDS.
Annals of internal medicine 1990;113(8):604-18.
1990: Shiraska T; Yarchoan R; Mitsuya H
[Antiviral chemotherapy for AIDS: dideoxynucleosides and clinical application]
Nippon rinsho. Japanese journal of clinical medicine 1990;48(9):2141-50.
1990: Ahluwalia G; Cooney D A; Bondoc L L; Currens M J; Ford H; Johns D G; Mitsuya H; Fridland A
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine.
Biochemical and biophysical research communications 1990;171(3):1297-303.
1990: Yarchoan R; Pluda J M; Thomas R V; Mitsuya H; Brouwers P; Wyvill K M; Hartman N; Johns D G; Broder S
Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex.
Lancet 1990;336(8714):526-9.
1990: Mitsuya H; Yarchoan R; Broder S
Molecular targets for AIDS therapy.
Science (New York, N.Y.) 1990;249(4976):1533-44.
1990: Yarchoan R; Mitsuya H; Broder S
Immunologic issues in anti-retroviral therapy.
Immunology today 1990;11(9):327-33.
1990: Yarchoan R; Mitsuya H; Pluda J M; Marczyk K S; Thomas R V; Hartman N R; Brouwers P; Perno C F; Allain J P; Johns D G
The National Cancer Institute phase I study of 2',3'-dideoxyinosine administration in adults with AIDS or AIDS-related complex: analysis of activity and toxicity profiles.
Reviews of infectious diseases 1990;12 Suppl 5():S522-33.
1990: Mitsuya H; Yarchoan R; Hayashi S; Broder S
Antiviral therapy against HIV infection.
Journal of the American Academy of Dermatology 1990;22(6 Pt 2):1282-94.
1990: Hartman N R; Johns D G; Mitsuya H
Pharmacokinetic analysis of dextran sulfate in rats as pertains to its clinical usefulness for therapy of HIV infection.
AIDS research and human retroviruses 1990;6(6):805-12.
1990: Wright J J; Gunter K C; Mitsuya H; Irving S G; Kelly K; Siebenlist U
Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells.
Science (New York, N.Y.) 1990;248(4955):588-91.
1990: Masood R; Ahluwalia G S; Cooney D A; Fridland A; Marquez V E; Driscoll J S; Hao Z; Mitsuya H; Perno C F; Broder S
2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosine.
Molecular pharmacology 1990;37(4):590-6.
1990: Marquez V E; Tseng C K; Mitsuya H; Aoki S; Kelley J A; Ford H; Roth J S; Broder S; Johns D G; Driscoll J S
Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV.
Journal of medicinal chemistry 1990;33(3):978-85.
1990: Hayashi S; Norbeck D W; Rosenbrook W; Fine R L; Matsukura M; Plattner J J; Broder S; Mitsuya H
Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro.
Antimicrobial agents and chemotherapy 1990;34(2):287-94.
1990: Hayashi S; Fine R L; Chou T C; Currens M J; Broder S; Mitsuya H
In vitro inhibition of the infectivity and replication of human immunodeficiency virus type 1 by combination of antiretroviral 2',3'-dideoxynucleosides and virus-binding inhibitors.
Antimicrobial agents and chemotherapy 1990;34(1):82-8.
1990: Yarchoan R; Mitsuya H; Broder S
Strategies for the combination therapy of HIV infection.
Journal of acquired immune deficiency syndromes 1990;3 Suppl 2():S99-103.
1990: Yarchoan R; Pluda J M; Perno C F; Mitsuya H; Thomas R V; Wyvill K M; Broder S
Initial clinical experience with dideoxynucleosides as single agents and in combination therapy.
Annals of the New York Academy of Sciences 1990;616():328-43.
1989: Yarchoan R; Mitsuya H; Myers C E; Broder S
Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.
The New England journal of medicine 1989;321(11):726-38.
1989: Lee S J; Hu W; Fisher A G; Looney D J; Kao V F; Mitsuya H; Ratner L; Wong-Staal F
Role of the carboxy-terminal portion of the HIV-1 transmembrane protein in viral transmission and cytopathogenicity.
AIDS research and human retroviruses 1989;5(4):441-9.
1989: Yarchoan R; Mitsuya H; Broder S
Clinical and basic advances in the antiretroviral therapy of human immunodeficiency virus infection.
The American journal of medicine 1989;87(2):191-200.
1989: Yarchoan R; Mitsuya H; Thomas R V; Pluda J M; Hartman N R; Perno C F; Marczyk K S; Allain J P; Johns D G; Broder S
In vivo activity against HIV and favorable toxicity profile of 2',3'-dideoxyinosine.
Science (New York, N.Y.) 1989;245(4916):412-5.
1989: Kohn D B; Mitsuya H; Ballow M; Selegue J E; Barankiewicz J; Cohen A; Gelfand E; Anderson W F; Blaese R M
Establishment and characterization of adenosine deaminase-deficient human T cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3971-7.
1989: Matsukura M; Zon G; Shinozuka K; Robert-Guroff M; Shimada T; Stein C A; Mitsuya H; Wong-Staal F; Cohen J S; Broder S
Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4244-8.
1989: Perno C F; Yarchoan R; Cooney D A; Hartman N R; Webb D S; Hao Z; Mitsuya H; Johns D G; Broder S
Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.
The Journal of experimental medicine 1989;169(3):933-51.
1988: Matsukura M; Zon G; Shinozuka K; Stein C A; Mitsuya H; Cohen J S; Broder S
Synthesis of phosphorothioate analogues of oligodeoxyribonucleotides and their antiviral activity against human immunodeficiency virus (HIV).
Gene 1988;72(1-2):343-7.
1988: Hayashi S; Phadtare S; Zemlicka J; Matsukura M; Mitsuya H; Broder S
Adenallene and cytallene: acyclic-nucleoside analogues that inhibit replication and cytopathic effect of human immunodeficiency virus in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):6127-31.
1988: Vidal C; Matsushita S; Colamonici O R; Trepel J B; Mitsuya H; Neckers L M
Human T lymphotropic virus I infection deregulates surface expression of the transferrin receptor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):984-8.
1988: Surbone A; Yarchoan R; McAtee N; Blum M R; Maha M; Allain J P; Thomas R V; Mitsuya H; Lehrman S N; Leuther M
Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study.
Annals of internal medicine 1988;108(4):534-40.
1988: Mitsuya H; Broder S
Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
AIDS research and human retroviruses 1988;4(2):107-13.
1988: Mitsuya H; Looney D J; Kuno S; Ueno R; Wong-Staal F; Broder S
Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.
Science (New York, N.Y.) 1988;240(4852):646-9.
1987: Matsukura M; Shinozuka K; Zon G; Mitsuya H; Reitz M; Cohen J S; Broder S
Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7706-10.
1987: Ahluwalia G; Cooney D A; Mitsuya H; Fridland A; Flora K P; Hao Z; Dalal M; Broder S; Johns D G
Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.
Biochemical pharmacology 1987;36(22):3797-800.
1987: Marquez V E; Tseng C K; Kelley J A; Mitsuya H; Broder S; Roth J S; Driscoll J S
2',3'-Dideoxy-2'-fluoro-ara-A. An acid-stable purine nucleoside active against human immunodeficiency virus (HIV).
Biochemical pharmacology 1987;36(17):2719-22.
1987: Cooney D A; Ahluwalia G; Mitsuya H; Fridland A; Johnson M; Hao Z; Dalal M; Balzarini J; Broder S; Johns D G
Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity.
Biochemical pharmacology 1987;36(11):1765-8.
1986: Cooney D A; Dalal M; Mitsuya H; McMahon J B; Nadkarni M; Balzarini J; Broder S; Johns D G
Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.
Biochemical pharmacology 1986;35(13):2065-8.
1986: Yarchoan R; Guo H G; Reitz M; Maluish A; Mitsuya H; Broder S
Alterations in cytotoxic and helper T cell function after infection of T cell clones with human T cell leukemia virus, type I.
The Journal of clinical investigation 1986;77(5):1466-73.

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