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Roberta Mittelstaedt

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Xiaoqing Guo; Robert H Heflich; Anita H Bigger; Lei Guo; Roberta A Mittelstaedt; Martha M Moore; Joseph G Shaddock; Nan Mei
Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells.
Yan Li; Roberta A Mittelstaedt; Jian Yan; Yongbin Zhang; Alexandru S Biris; David H Chen; Ying Chen; Robert H Heflich; Tao Chen
Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay.
Wei Ding; Daniel R Doerge; Anane Aidoo; Michelle E Bishop; Ching-Wei Chang; John R Latendresse; Mugimane G Manjanatha; Lea P McDaniel; Roberta A Mittelstaedt; Suzanne M Morris; Levan Muskhelishvili; Mason G Pearce; Dayton M Petibone; Joseph G Shaddock; Gene A White; Robert H Heflich
In vivo genotoxicity of furan in F344 rats at cancer bioassay doses.

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All Publications

2013: Xiaoqing Guo; Robert H Heflich; Anita H Bigger; Lei Guo; Roberta A Mittelstaedt; Martha M Moore; Joseph G Shaddock; Nan Mei
Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells.
Toxicology in vitro : an international journal published in association with BIBRA 2013;27(5):1496-502.
2012: Yan Li; Roberta A Mittelstaedt; Jian Yan; Yongbin Zhang; Alexandru S Biris; David H Chen; Ying Chen; Robert H Heflich; Tao Chen
Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay.
Mutation research 2012;745(1-2):4-10.
2012: Wei Ding; Daniel R Doerge; Anane Aidoo; Michelle E Bishop; Ching-Wei Chang; John R Latendresse; Mugimane G Manjanatha; Lea P McDaniel; Roberta A Mittelstaedt; Suzanne M Morris; Levan Muskhelishvili; Mason G Pearce; Dayton M Petibone; Joseph G Shaddock; Gene A White; Robert H Heflich
In vivo genotoxicity of furan in F344 rats at cancer bioassay doses.
Toxicology and applied pharmacology 2012;261(2):164-71.
2012: L Patrice McDaniel; Roberta A Mittelstaedt; Joseph G Shaddock; Wei Ding; Vasily N Dobrovolsky; Daniel R Doerge; Robert H Heflich
Genotoxicity of furan in Big Blue rats.
Mutation research 2012;742(1-2):72-8.
2012: Varsha G Desai; William S Branham; Julian E A Leakey; Taewon Lee; Sherry M Lewis; Roberta A Mittelstaedt; Carrie L Moland; James C Fuscoe
Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F(1) Mice.
AIDS research and treatment 2012;2012():317695.
2011: Rahat Ali; Roberta A Mittelstaedt; Joseph G Shaddock; Wei Ding; Javed Bhalli; Qaiser M Khan; Robert H Heflich
Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines.
Mutation research 2011;723(1):58-64.
2010: Nan Mei; Lea P McDaniel; Vasily N Dobrovolsky; Xiaoqing Guo; Joseph G Shaddock; Roberta A Mittelstaedt; Mizuo Azuma; Sharon D Shelton; Lynda J McGarrity; Daniel R Doerge; Robert H Heflich
The genotoxicity of acrylamide and glycidamide in big blue rats.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(2):412-21.
2009: Suzanne M Morris; Vasily N Dobrovolsky; Joseph G Shaddock; Roberta A Mittelstaedt; Michelle E Bishop; Mugimane G Manjanatha; Sharon D Shelton; Daniel R Doerge; Nathan C Twaddle; James J Chen; Chien-Ju Lin; Merle Paule; William Slikker; Charlotte E Hotchkiss; Dayton Petibone; James Tucker; Donald R Mattison
The genetic toxicology of methylphenidate hydrochloride in non-human primates.
Mutation research 2009;673(1):59-66.
2009: Vasily N Dobrovolsky; Joseph G Shaddock; Roberta A Mittelstaedt; Mugimane G Manjanatha; Daishiro Miura; Makoto Uchikawa; Donald R Mattison; Suzanne M Morris
Evaluation of Macaca mulatta as a model for genotoxicity studies.
Mutation research 2009;673(1):21-8.
2008: Daishiro Miura; Vasily N Dobrovolsky; Roberta A Mittelstaedt; Yoshinori Kasahara; Yasuhiro Katsuura; Robert H Heflich
Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants.
Environmental and molecular mutagenesis 2008;49(8):622-30.
2007: Vasily N Dobrovolsky; Joseph G Shaddock; Roberta A Mittelstaedt; Michelle E Bishop; Sherry M Lewis; Fei W Lee; Anane Aidoo; Julian E A Leakey; June K Dunnick; Robert H Heflich
Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC.
Environmental and molecular mutagenesis 2007;48(3-4):270-82.
2007: Linda S Von Tungeln; Lee D Williams; Daniel R Doerge; Joseph G Shaddock; Lynda J McGarrity; Suzanne M Morris; Roberta A Mittelstaedt; Robert H Heflich; Frederick A Beland
Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine.
Environmental and molecular mutagenesis 2007;48(3-4):258-69.
2006: Joseph G Shaddock; Vasily N Dobrovolsky; Roberta A Mittelstaedt; Robert H Heflich; Barbara L Parsons
Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice.
Mutation research 2006;595(1-2):69-79.
2005: Tao Chen; Roberta A Mittelstaedt; Frederick A Beland; Robert H Heflich; Martha M Moore; Barbara L Parsons
4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice.
International journal of cancer. Journal international du cancer 2005;117(2):182-7.
2005: Vasily N Dobrovolsky; Lynda J McGarrity; Linda S VonTungeln; Roberta A Mittelstaedt; Suzanne M Morris; Frederick A Beland; Robert H Heflich
Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice.
Mutation research 2005;570(2):227-35.
2004: Roberta A Mittelstaedt; Nan Mei; Peggy J Webb; Joseph G Shaddock; Vasily N Dobrovolsky; Lynda J McGarrity; Suzanne M Morris; Tao Chen; Frederick A Beland; Kevin J Greenlees; Robert H Heflich
Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice.
Mutation research 2004;561(1-2):127-38.
2004: Roberta A Mittelstaedt; Linda S Von Tungeln; Joseph G Shaddock; Vasily N Dobrovolsky; Frederick A Beland; Robert H Heflich
Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).
Mutation research 2004;547(1-2):63-9.
2003: Vasily N Dobrovolsky; Page B McKinzie; Joseph G Shaddock; Roberta A Mittelstaedt; Robert H Heflich; Barbara L Parsons
Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice.
Mutagenesis 2003;18(4):365-70.
2003: Anane Aidoo; Roberta A Mittelstaedt; Michelle E Bishop; Lascelles E Lyn-Cook; Yi-Ju Chen; Peter Duffy; Robert H Heflich
Effect of caloric restriction on Hprt lymphocyte mutation in aging rats.
Mutation research 2003;527(1-2):57-66.
2001: Tao Chen; Roberta A Mittelstaedt; Sharon D Shelton; S. Bala Dass; Mugimane G Manjanatha; Daniel A Casciano; Robert H Heflich
Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene.
Environmental and molecular mutagenesis 2001;37(3):203-14.
2001: Tao Chen; Roberta A Mittelstaedt; Anane Aidoo; L P Hamilton; Frederick A Beland; Daniel A Casciano; Robert H Heflich
Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats.
Environmental and molecular mutagenesis 2001;37(3):195-202.
1999: Daniel A Casciano; Anane Aidoo; T Chen; Roberta A Mittelstaedt; Mugimane G Manjanatha; Robert H Heflich
Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens.
Mutation research 1999;431(2):389-95.
1999: Roberta A Mittelstaedt; BA Smith; Tao Chen; Frederick A Beland; Robert H Heflich
Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene.
Mutation research 1999;431(1):167-73.
1999: Frederick A Beland; NF Fullerton; BA Smith; Roberta A Mittelstaedt; Robert H Heflich
Hprt lymphocyte mutant frequency in relation to DNA adduct formation in rats fed the hepatocarcinogen 2-acetylaminofluorene.
Cancer letters 1999;143(2):249-55.
1999: Tao Chen; Anane Aidoo; Roberta A Mittelstaedt; Daniel A Casciano; Robert H Heflich
Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa.
Carcinogenesis 1999;20(2):269-77.
1998: Tao Chen; Anane Aidoo; Mugimane G Manjanatha; Roberta A Mittelstaedt; Sharon D Shelton; Lascelles E Lyn-Cook; Daniel A Casciano; Robert H Heflich
Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats.
Mutation research 1998;403(1-2):199-214.
1998: Tao Chen; Roberta A Mittelstaedt; Robert H Heflich
DNA sequence flanking the protein coding regions of the rat Hprt gene.
Mutation research 1998;382(3-4):79-80.
1998: Roberta A Mittelstaedt; Mugimane G Manjanatha; Sharon D Shelton; Lascelles E Lyn-Cook; J B Chen; Anane Aidoo; Daniel A Casciano; Robert H Heflich
Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats.
Environmental and molecular mutagenesis 1998;31(2):149-56.
1997: BA Smith; Mugimane G Manjanatha; Igor P Pogribny; Roberta A Mittelstaedt; Tao Chen; NF Fullerton; Frederick A Beland; Robert H Heflich
Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.
Mutation research 1997;379(1):61-8.
1996: Robert H Heflich; Roberta A Mittelstaedt; Mugimane G Manjanatha; Lascelles E Lyn-Cook; Anane Aidoo
DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene.
Environmental and molecular mutagenesis 1996;28(1):5-12.
1995: Roberta A Mittelstaedt; B A Smith; Robert H Heflich
Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes.
Environmental and molecular mutagenesis 1995;26(4):261-9.
1994: Roberta A Mittelstaedt; Robert H Heflich
Analysis of in vivo mutation in exon 8 of the rat hprt gene.
Mutation research 1994;311(1):139-48.
1994: Mugimane G Manjanatha; L A Lindsey; Roberta A Mittelstaedt; Robert H Heflich
Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations.
Mutation research 1994;308(1):65-75.
1993: Mugimane G Manjanatha; R K Newton; Roberta A Mittelstaedt; G R Villani; K B Declos; Robert H Heflich
Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in Chinese hamster ovary cells.
Carcinogenesis 1993;14(9):1863-70.
1993: K B Delclos; Mugimane G Manjanatha; E E Li; R K Newton; Roberta A Mittelstaedt; Robert H Heflich
32P-postlabelling in studies of arylamine and nitroaromatic hydrocarbon activation and mutagenesis.
IARC scientific publications 1993;(124):79-86.
1992: R K Newton; Roberta A Mittelstaedt; Mugimane G Manjanatha; Robert H Heflich
DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of Chinese hamster ovary cells.
Carcinogenesis 1992;13(5):819-25.
1992: R K Newton; Roberta A Mittelstaedt; Robert H Heflich
Analysis of solvent control and 1-nitrosopyrene-induced Chinese hamster ovary cell mutants by Southern and northern blots and the polymerase chain reaction.
Environmental and molecular mutagenesis 1992;19(2):147-55.
1992: R E Neft; A L Roe; H M Schol; Peter P Fu; Roberta A Mittelstaedt; Daniel A Casciano
Nitrobenzo[a]pyrene-induced DNA amplification in SV40-transformed Chinese hamster embryo cells.
Environmental and molecular mutagenesis 1992;19(2):156-60.
1991: Ritchie J Feuers; Roberta A Mittelstaedt; J D Hunter; J Saldivar; T H Tsai; L E Scheving
Circadian variation in alloxan sensitivity of mice as indicated by mortality and blood glucose alteration.
Chronobiology international 1991;8(1):67-74.
1991: Anane Aidoo; Lascelles E Lyn-Cook; Roberta A Mittelstaedt; Robert H Heflich; Daniel A Casciano
Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide.
Environmental and molecular mutagenesis 1991;17(3):141-51.
1989: Ritchie J Feuers; Peter H Duffy; J A Leakey; Angelo Turturro; Roberta A Mittelstaedt; Ronald W Hart
Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat.
Mechanisms of ageing and development 1989;48(2):179-89.