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Robert Mittler
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Network (preview)
9
Foell, Juergen
9
Vella, Anthony
8
Hoffmann, Michael
7
Ledbetter, Jeffrey
6
Kiener, Peter
5
Kwon, Byoung
5
Aruffo, Alejandro
5
Bapat, Abhijit
4
Larsen, Christian
4
Myers, Lara
4
Orlikowsky, Thorsten
4
Rossi, Robert
3
Shuford, WW
3
Pearson, Thomas
3
Nadler, Steven
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Geonetwork of Robert Mittler (preview)
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All Publications
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2008: Bandyopadhyay Suman; Long Meixiao; Qui Harry Z; Hagymasi Adam T; Slaiby Aaron M; Mihalyo Marianne A; Aguila Hector L; Mittler Robert S; Vella Anthony T; Adler Adam J
Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7728-37.
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2008: McNamara James O; Kolonias Despina; Pastor Fernando; Mittler Robert S; Chen Lieping; Giangrande Paloma H; Sullenger Bruce; Gilboa Eli
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
The Journal of clinical investigation 2008;118(1):376-86.
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2007: Zhang Benyue; Maris Charles H; Foell Juergen; Whitmire Jason; Niu Liguo; Song Jing; Kwon Byoung S; Vella Anthony T; Ahmed Rafi; Jacob Joshy; Mittler Robert S
Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent.
The Journal of clinical investigation 2007;117(10):3029-41.
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2007: Polte T; Jagemann A; Foell J; Mittler R S; Hansen G
CD137 ligand prevents the development of T-helper type 2 cell-mediated allergic asthma by interferon-gamma-producing CD8+ T cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(9):1374-85.
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2007: Moens Leen; Jeurissen Axel; Mittler Robert S; Wuyts Greet; Michiels George; Boon Louis; Ceuppens Jan L; Bossuyt Xavier
Distinct approaches to investigate the importance of the murine 4-1BB 4-1BBL interaction in the antibody response to Streptococcus pneumoniae.
Journal of leukocyte biology 2007;82(3):638-44.
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2007: Lee Seung-Joo; Rossi Robert J; Lee Sun-Kyeong; Croft Michael; Kwon Byoung S; Mittler Robert S; Vella Anthony T
CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2203-14.
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2007: Niu Liguo; Strahotin Simona; Hewes Becker; Zhang Benyue; Zhang Yuanyuan; Archer David; Spencer Trent; Dillehay Dirck; Kwon Byoung; Chen Lieping; Vella Anthony T; Mittler Robert S
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4194-213.
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2007: Foell Jeurgen; Hewes Becker; Mittler Robert S
T cell costimulatory and inhibitory receptors as therapeutic targets for inducing anti-tumor immunity.
Current cancer drug targets 2007;7(1):55-70.
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2007: Irie Junichiro; Wu Yuehong; Kachapati Kritika; Mittler Robert S; Ridgway William M
Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetes.
Diabetes 2007;56(1):186-96.
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2006: Ménoret Antoine; Myers Lara M; Lee Seung-Joo; Mittler Robert S; Rossi Robert J; Vella Anthony T
TGFbeta protein processing and activity through TCR triggering of primary CD8+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6091-7.
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2006: Foell Juergen; Mittler Robert S
Costimulatory molecules as immunotherapeutic targets in systemic lupus erythematosus.
Springer seminars in immunopathology 2006;28(2):153-62.
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2006: McMillin Douglas W; Hewes Becker; Gangadharan Bagirath; Archer David R; Mittler Robert S; Spencer H Trent
Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy.
Human gene therapy 2006;17(8):798-806.
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2006: Polte Tobias; Foell Juergen; Werner Christoph; Hoymann Heinz-Gerd; Braun Armin; Burdach Stefan; Mittler Robert S; Hansen Gesine
CD137-mediated immunotherapy for allergic asthma.
The Journal of clinical investigation 2006;116(4):1025-36.
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2006: Myers Lara; Lee Seung Woo; Rossi Robert J; Lefrancois Leo; Kwon Byoung S; Mittler Robert S; Croft Michael; Vella Anthony T
Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells.
International immunology 2006;18(2):325-33.
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2005: Myers Lara; Croft Michael; Kwon Byoung S; Mittler Robert S; Vella Anthony T
Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7625-32.
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2004: Lee Seung-Joo; Myers Lara; Muralimohan Guruprasaadh; Dai Jie; Qiao Yi; Li Zihai; Mittler Robert S; Vella Anthony T
4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3002-12.
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2004: Foell Juergen L; Diez-Mendiondo Belkis I; Diez Oliver H; Holzer Ursula; Ruck Peter; Bapat Abhijit S; Hoffmann Michael K; Mittler Robert S; Dannecker Guenther E
Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance.
Immunology 2004;113(1):89-98.
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2004: Cho H R; Kwon B; Yagita H; La S; Lee E A; Kim J-E; Akiba H; Kim J; Suh J-H; Vinay D S; Ju S-A; Kim B-S; Mittler R S; Okumura K; Kwon B S
Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.
Transplant international : official journal of the European Society for Organ Transplantation 2004;17(7):351-61.
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2004: Munks Michael W; Mourich Dan V; Mittler Robert S; Weinberg Andrew D; Hill Ann B
4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.
Immunology 2004;112(4):559-66.
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2004: Mittler Robert S; Foell Juergen; McCausland Megan; Strahotin Simona; Niu Liguo; Bapat Abhijit; Hewes L Becker
Anti-CD137 antibodies in the treatment of autoimmune disease and cancer.
Immunologic research 2004;29(1-3):197-208.
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2003: Wang Jun; Guo Zhong; Dong Ying; Kim Oliver; Hart John; Adams Andrew; Larsen Christian P; Mittler Robert S; Newell Kenneth A
Role of 4-1BB in allograft rejection mediated by CD8+ T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(5):543-51.
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2003: Foell Juergen; Strahotin Simona; O'Neil Shawn P; McCausland Megan M; Suwyn Carolyn; Haber Michael; Chander Praveen N; Bapat Abhijit S; Yan Xiao-Jie; Chiorazzi Nicholas; Hoffmann Michael K; Mittler Robert S
CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice.
The Journal of clinical investigation 2003;111(10):1505-18.
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2003: Foell Juergen; McCausland Megan; Burch Jennifer; Corriazzi Nicholas; Yan Xiao-Jie; Suwyn Carolyn; O'Neil Shawn P; Hoffmann Michael K; Mittler Robert S
CD137-mediated T cell co-stimulation terminates existing autoimmune disease in SLE-prone NZB/NZW F1 mice.
Annals of the New York Academy of Sciences 2003;987():230-5.
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2003: Myers Lara; Takahashi Chikara; Mittler Robert S; Rossi Robert J; Vella Anthony T
Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5348-53.
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2003: Wu Zheng-Qi; Khan Abdul Q; Shen Yi; Wolcott Karen M; Dawicki Wojciech; Watts Tania H; Mittler Robert S; Snapper Clifford M
4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae.
Infection and immunity 2003;71(1):196-204.
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2002: Wilcox Ryan A; Chapoval Andrei I; Gorski Kevin S; Otsuji Mizuto; Shin Tahiro; Flies Dallas B; Tamada Koji; Mittler Robert S; Tsuchiya Haruo; Pardoll Drew M; Chen Lieping
Cutting edge: Expression of functional CD137 receptor by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4262-7.
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2002: Diehl Linda; van Mierlo Geertje J D; den Boer Annemieke T; van der Voort Ellen; Fransen Marieke; van Bostelen Liesbeth; Krimpenfort Paul; Melief Cornelis J M; Mittler Robert; Toes Rene E M; Offringa Rienk
In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3755-62.
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2000: Tan J T; Ha J; Cho H R; Tucker-Burden C; Hendrix R C; Mittler R S; Pearson T C; Larsen C P
Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.
Transplantation 2000;70(1):175-83.
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2000: Tan J T; Whitmire J K; Murali-Krishna K; Ahmed R; Altman J D; Mittler R S; Sette A; Pearson T C; Larsen C P
4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2320-5.
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1999: Mittler R S; Bailey T S; Klussman K; Trailsmith M D; Hoffmann M K
Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy.
The Journal of experimental medicine 1999;190(10):1535-40.
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1999: Wang Z q; Horowitz H W; Orlikowsky T; Hahn B I; Trejo V; Bapat A S; Mittler R S; Rayanade R J; Yang S Y; Hoffmann M K
Polyspecific self-reactive antibodies in individuals infected with human immunodeficiency virus facilitate T cell deletion and inhibit costimulatory accessory cell function.
The Journal of infectious diseases 1999;180(4):1072-9.
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1999: Wang Z Q; Bapat A S; Trejo V; Orlikowsky T; Mittler R S; Hoffmann M K
MHC class I molecules on CD4 T cells regulate receptor-mediated activation signals.
Cellular immunology 1999;193(1):108-14.
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1998: Melero I; Johnston J V; Shufford W W; Mittler R S; Chen L
NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.
Cellular immunology 1998;190(2):167-72.
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1998: Orlikowsky T; Wang Z; Dudhane A; Mittler R; Trejo V; Dannecker G E; Niethammer D; Hoffmann M K
Elevated major histocompatibility complex class I expression protects T cells from antibody- and macrophage-mediated deletion.
Immunology 1998;95(3):437-42.
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1998: Melero I; Bach N; Hellström K E; Aruffo A; Mittler R S; Chen L
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway.
European journal of immunology 1998;28(3):1116-21.
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1997: Shuford W W; Klussman K; Tritchler D D; Loo D T; Chalupny J; Siadak A W; Brown T J; Emswiler J; Raecho H; Larsen C P; Pearson T C; Ledbetter J A; Aruffo A; Mittler R S
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
The Journal of experimental medicine 1997;186(1):47-55.
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1997: Melero I; Shuford W W; Newby S A; Aruffo A; Ledbetter J A; Hellström K E; Mittler R S; Chen L
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.
Nature medicine 1997;3(6):682-5.
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1997: Loo D T; Chalupny N J; Bajorath J; Shuford W W; Mittler R S; Aruffo A
Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB.
The Journal of biological chemistry 1997;272(10):6448-56.
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1997: Ledbetter J A; Francisco J A; Siegall C B; Gilliland L K; Hollenbaugh D; Aruffo A; Siadak A W; Mischel-Petty N; Grosmaire L S; Gordon M L; Brown T J; Moran-Davis P; Mittler R S; Kiener P A; Nadler S G
Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.
Critical reviews in immunology 1997;17(5-6):427-35.
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1996: Cabrian K M; Berry K K; Shuford W W; Mittler R S; Rodgers J N; Linsley P S
Suppression of T-cell-dependent immune responses in monkeys by CTLA4Ig.
Transplantation proceedings 1996;28(6):3261-2.
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1996: Brown T J; Shuford W W; Wang W C; Nadler S G; Bailey T S; Marquardt H; Mittler R S
Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells.
The Journal of biological chemistry 1996;271(44):27686-95.
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1996: Winberg G; Grosmaire L S; Klussman K; Hayden M S; Fell H P; Ledbetter J A; Mittler R S
Surface expression of CD28 single chain Fv for costimulation by tumor cells.
Immunological reviews 1996;153():209-23.
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1996: Hayden M S; Grosmaire L S; Norris N A; Gilliland L K; Winberg G; Tritschler D; Tsu T T; Linsley P S; Mittler R S; Senter P D; Fell H P; Ledbetter J A
Costimulation by CD28 sFv expressed on the tumor cell surface or as a soluble bispecific molecule targeted to the L6 carcinoma antigen.
Tissue antigens 1996;48(4 Pt 1):242-54.
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1996: Linsley P S; Bradshaw J; Greene J; Peach R; Bennett K L; Mittler R S
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.
Immunity 1996;4(6):535-43.
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1996: Gilliland L K; Norris N A; Marquardt H; Tsu T T; Hayden M S; Neubauer M G; Yelton D E; Mittler R S; Ledbetter J A
Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments.
Tissue antigens 1996;47(1):1-20.
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1994: Schieven G L; Mittler R S; Nadler S G; Kirihara J M; Bolen J B; Kanner S B; Ledbetter J A
ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.
The Journal of biological chemistry 1994;269(32):20718-26.
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1994: Wang Z Q; Orlikowsky T; Dudhane A; Mittler R; Blum M; Lacy E; Riethmüller G; Hoffmann M K
Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV-gp120 and gp120-specific antibodies from AIDS patients.
European journal of immunology 1994;24(7):1553-7.
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1994: Mittler R S; Schieven G L; Dubois P M; Klussman K; O'Connell M P; Kiener P A; Herndon V
CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):84-96.
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1993: Rankin B M; Yocum S A; Mittler R S; Kiener P A
Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):605-16.
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1991: Mittler R S; Rankin B M; Kiener P A
Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3434-40.
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1990: Mittler R S; Fifer C A; Burbach P; Edinger K; Kiener P A
Evidence for a new HLA determinant that causes T cell activation without costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(3):794-803.
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1989: Kiener P A; Mittler R S
CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):23-8.
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