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Robert Mittler

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Kritika Kachapati; Robert S Mittler; Dan Rainbow; Charles A Steward; Linda S Wicker; Yuehong Wu; David E Adams; William M Ridgway
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model.
Hye J Kim; Ahra Kim; Jong S Lee; Sun K Lee; Robert S Mittler; Jung D Kim; Hee J Cha; Hong R Cho; Byoung S Kwon; Sang C Lee; Byungsuk Kwon
Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation.
Juyang Kim; Sohye Park; Hye-Jung Choi; Hong R Cho; Wongyoung Kim; Hyun-A Kim; Sang J Park; Daehee Jung; Hyun J Kim; Robert S Mittler; Byungsuk Kwon
Host CD25+CD4+Foxp3+ regulatory T cells primed by anti-CD137 mAbs inhibit graft-versus-host disease.

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2012: Kritika Kachapati; Robert S Mittler; Dan Rainbow; Charles A Steward; Linda S Wicker; Yuehong Wu; David E Adams; William M Ridgway
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):5001-15.
2012: Hye J Kim; Ahra Kim; Jong S Lee; Sun K Lee; Robert S Mittler; Jung D Kim; Hee J Cha; Hong R Cho; Byoung S Kwon; Sang C Lee; Byungsuk Kwon
Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(1):E13-22.
2012: Juyang Kim; Sohye Park; Hye-Jung Choi; Hong R Cho; Wongyoung Kim; Hyun-A Kim; Sang J Park; Daehee Jung; Hyun J Kim; Robert S Mittler; Byungsuk Kwon
Host CD25+CD4+Foxp3+ regulatory T cells primed by anti-CD137 mAbs inhibit graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012;18(1):44-54.
2011: Harry Z Qui; Raghunath Ramanarasimhaiah; Steven L Reiner; Marie-Clare St Rose; Anthony T Vella; Suman Bandyopadhyay; Scott M Gordon; Adam T Hagymasi; Antoine Ménoret; Robert S Mittler; Adam J. Adler
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3555-64.
2011: Vaiva Vezys; Daniel L Barber; Gordon J Freeman; Sang-Jun Ha; Bogumila T Konieczny; Robert S Mittler; Pablo Penaloza-MacMaster; Rafi Ahmed
4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1634-42.
2010: Jessica C Engram; Barbara Cervasi; Jose A M Borghans; Nichole R Klatt; Shari N Gordon; Ann Chahroudi; James ELSE; Robert S Mittler; Donald L Sodora; Rob J de Boer; Jason M Brenchley; Guido Silvestri; Mirko Paiardini
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.
Blood 2010;116(5):748-58.
2010: Ioanna Skountzou; Dimitrios G Koutsonanos; Jin Hyang Kim; Ryan Powers; Lakshmipriyadarshini Satyabhama; Feda Masseoud; William C Weldon; Maria Del Pilar Martin; Robert S Mittler; Richard W Compans; Joshy Jacob
Immunity to pre-1950 H1N1 influenza viruses confers cross-protection against the pandemic swine-origin 2009 A (H1N1) influenza virus.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1642-9.
2010: Benyue Zhang; Yuanyuan Zhang; Liguo Niu; Anthony T Vella; Robert S Mittler
Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(9):4770-8.
2010: Sumita Ganguly; Jinyan Liu; Vinod B Pillai; Robert S Mittler; Rama Rao Amara
Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: different effects on cellular and humoral immunity.
Vaccine 2010;28(5):1300-9.
2009: Rich-Henry Schabowsky; Kutlu G Elpek; shravan madireddi; Rajesh Kumar Sharma; Esma S Yolcu; Laura Bandura-Morgan; Robert Miller; Kathryn J MacLeod; Robert S Mittler; Haval Shirwan
A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity.
Vaccine 2009;28(2):512-22.
2009: Seung-Woo Lee; Shahram Salek-Ardakani; Robert S Mittler; Michael Croft
Hypercostimulation through 4-1BB distorts homeostasis of immune cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6753-62.
2009: Young H Kim; Beom K Choi; Ho S Oh; Woo J Kang; Robert S Mittler; Byoung S Kwon
Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy.
Molecular cancer therapeutics 2009;8(2):469-78.
2009: Mirko Paiardini; Barbara Cervasi; Jessica C Engram; Shari N Gordon; Nichole R Klatt; Alagarraju Muthukumar; James ELSE; Robert S Mittler; Silvija I Staprans; Donald L Sodora; Guido Silvestri
Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.
Blood 2009;113(3):612-21.
2009: Tamaki Sumi; Waka Ishida; Robert S Mittler; Hideo Yagita; Osamu Taguchi; Atsuki Fukushima
Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis.
International archives of allergy and immunology 2009;148(4):305-10.
2009: Seung-Joo Lee; Meixiao Long; Adam J. Adler; Robert S Mittler; Anthony T Vella
The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death.
Journal of leukocyte biology 2009;85(1):175-85.
2008: Suman Bandyopadhyay; Meixiao Long; Harry Z Qui; Adam T Hagymasi; Aaron M Slaiby; Marianne A Mihalyo; Hector L Aguila; Robert S Mittler; Anthony T Vella; Adam J. Adler
Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7728-37.
2008: Seung-Woo Lee; Yunji Park; Takanori So; Byoung S Kwon; Hilde Cheroutre; Robert S Mittler; Michael Croft
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Nature immunology 2008;9(8):917-26.
2008: Shelly J Robertson; Ronald J Messer; Aaron B Carmody; Robert S Mittler; Christopher Burlak; Kim J Hasenkrug
CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5267-74.
2008: James O McNamara; Despina Kolonias; Fernando Pastor; Robert S Mittler; Lieping Chen; Paloma H Giangrande; Bruce A Sullenger; Eli Gilboa
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
The Journal of clinical investigation 2008;118(1):376-86.
2007: Benyue Zhang; Charles H Maris; Juergen Foell; Jason K Whitmire; Liguo Niu; Jing Song; Byoung S Kwon; Anthony T Vella; Rafi Ahmed; Joshy Jacob; Robert S Mittler
Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent.
The Journal of clinical investigation 2007;117(10):3029-41.
2007: Tobias Polte; A Jagemann; Juergen Foell; Robert S Mittler; Gesine Hansen
CD137 ligand prevents the development of T-helper type 2 cell-mediated allergic asthma by interferon-gamma-producing CD8+ T cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(9):1374-85.
2007: Leen Moens; Axel Jeurissen; Robert S Mittler; Greet Wuyts; George Michiels; Louis Boon; Jan L Ceuppens; Xavier Bossuyt
Distinct approaches to investigate the importance of the murine 4-1BB 4-1BBL interaction in the antibody response to Streptococcus pneumoniae.
Journal of leukocyte biology 2007;82(3):638-44.
2007: Seung-Joo Lee; Robert J Rossi; Sun-Kyeong Lee; Michael Croft; Byoung S Kwon; Robert S Mittler; Anthony T Vella
CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2203-14.
2007: Liguo Niu; Simona Strahotin; Becker Hewes; Benyue Zhang; Yuanyuan Zhang; David Archer; H Trent Spencer; Dirck L Dillehay; Byungsuk Kwon; Lieping Chen; Anthony T Vella; Robert S Mittler
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4194-213.
2007: Elsa M Laughlin; Joseph D Miller; Eddie James; Dimitri Fillos; Chris C Ibegbu; Robert S Mittler; Rama Akondy; William Kwok; Rafi Ahmed; Gerald Nepom
Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.
Infection and immunity 2007;75(4):1852-60.
2007: Juergen Foell; Becker Hewes; Robert S Mittler
T cell costimulatory and inhibitory receptors as therapeutic targets for inducing anti-tumor immunity.
Current cancer drug targets 2007;7(1):55-70.
2007: Junichiro Irie; Yuehong Wu; Kritika Kachapati; Robert S Mittler; William M Ridgway
Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetes.
Diabetes 2007;56(1):186-96.
2006: Antoine Ménoret; Lara M Myers; Seung-Joo Lee; Robert S Mittler; Robert J Rossi; Anthony T Vella
TGFbeta protein processing and activity through TCR triggering of primary CD8+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6091-7.
2006: Juergen Foell; Robert S Mittler
Costimulatory molecules as immunotherapeutic targets in systemic lupus erythematosus.
Springer seminars in immunopathology 2006;28(2):153-62.
2006: Douglas W McMillin; Becker Hewes; Bagirath Gangadharan; David R Archer; Robert S Mittler; H Trent Spencer
Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy.
Human gene therapy 2006;17(8):798-806.
2006: Tomoyasu Uno; Kazuyoshi Takeda; Yuko Kojima; Hirohisa Yoshizawa; Hisaya Akiba; Robert S Mittler; Fumitake Gejyo; Ko Okumura; Hideo Yagita; Mark J Smyth
Eradication of established tumors in mice by a combination antibody-based therapy.
Nature medicine 2006;12(6):693-8.
2006: Tobias Polte; Juergen Foell; Christoph Werner; Heinz G Hoymann; Armin Braun; Stefan Burdach; Robert S Mittler; Gesine Hansen
CD137-mediated immunotherapy for allergic asthma.
The Journal of clinical investigation 2006;116(4):1025-36.
2006: Elizabeth A Wohlfert; Leonid Gorelik; Robert S Mittler; Richard A Flavell; Robert B Clark
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1316-20.
2006: Lara Myers; Seung Woo Lee; Robert J Rossi; Leo Lefrancois; Byoung S Kwon; Robert S Mittler; Michael Croft; Anthony T Vella
Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells.
International immunology 2006;18(2):325-33.
2005: Hajime Nishimoto; Seung-Woo Lee; Hong Hong; Karen G Potter; Mari Maeda-Yamamoto; Tatsuya Kinoshita; Yuko Kawakami; Robert S Mittler; Byoung S Kwon; Carl Ware; Michael Croft; Toshiaki Kawakami
Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor.
Blood 2005;106(13):4241-8.
2005: Atsuki Fukushima; Tomoko Yamaguchi; Waka Ishida; Kazuyo Fukata; Robert S Mittler; Hideo Yagita; Hisayuki Ueno
Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):4897-903.
2005: Camilo Cuadros; Ana Lucia Dominguez; Pier-Luigi Lollini; Michael Croft; Robert S Mittler; Per Borgström; Joseph Lustgarten
Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice.
International journal of cancer. Journal international du cancer 2005;116(6):934-43.
2005: Lara Myers; Michael Croft; Byoung S Kwon; Robert S Mittler; Anthony T Vella
Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7625-32.
2004: Robert S Mittler
Suppressing the self in rheumatoid arthritis.
Nature medicine 2004;10(10):1047-9.
2004: Seung-Joo Lee; Lara Myers; Guruprasaadh Muralimohan; Jie Dai; Yi Qiao; Zihai Li; Robert S Mittler; Anthony T Vella
4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3002-12.
2004: Juergen Foell; Belkis I Diez-Mendiondo; Oliver H Diez; Ursula Holzer; Peter Ruck; Abhijit S Bapat; Michael K Hoffmann; Robert S Mittler; Guenther E Dannecker
Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance.
Immunology 2004;113(1):89-98.
2004: Hong Rae Cho; Byungsuk Kwon; Hideo Yagita; Soojin La; Eun-A Lee; Jeong-Eun Kim; H Akiba; Juyang Kim; Jae-Hee Suh; Dass S Vinay; Seong-A Ju; Byung-Sam Kim; Robert S Mittler; K Okumura; Byoung S Kwon
Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.
Transplant international : official journal of the European Society for Organ Transplantation 2004;17(7):351-61.
2004: Michael W Munks; Dan V Mourich; Robert S Mittler; Andrew D Weinberg; Ann B Hill
4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.
Immunology 2004;112(4):559-66.
2004: Robert S Mittler; Juergen Foell; Megan McCausland; Simona Strahotin; Liguo Niu; Abhijit S Bapat; L Becker Hewes
Anti-CD137 antibodies in the treatment of autoimmune disease and cancer.
Immunologic research 2004;29(1-3):197-208.
2003: Jun Wang; Zhong Guo; Ying Dong; Oliver Kim; John Hart; Andrew Adams; Christian P Larsen; Robert S Mittler; Kenneth A Newell
Role of 4-1BB in allograft rejection mediated by CD8+ T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(5):543-51.
2003: Juergen Foell; Simona Strahotin; Shawn P O'Neil; Megan McCausland; Carolyn Suwyn; Michael Haber; Praveen N Chander; Abhijit S Bapat; Joy (Xiao-Jie) Yan; Nicholas Chiorazzi; Michael K Hoffmann; Robert S Mittler
CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice.
The Journal of clinical investigation 2003;111(10):1505-18.
2003: Lara Myers; Chikara Takahashi; Robert S Mittler; Robert J Rossi; Anthony T Vella
Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5348-53.
2003: Juergen Foell; Megan McCausland; Jennifer Burch; Nicholas Corriazzi; Joy (Xiao-Jie) Yan; Carolyn Suwyn; Shawn P O'Neil; Michael K Hoffmann; Robert S Mittler
CD137-mediated T cell co-stimulation terminates existing autoimmune disease in SLE-prone NZB/NZW F1 mice.
Annals of the New York Academy of Sciences 2003;987():230-5.
2003: Zheng-Qi Wu; Abdul Q Khan; Yi Shen; Karen M Wolcott; Wojciech Dawicki; Tania H Watts; Robert S Mittler; Clifford M Snapper
4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae.
Infection and immunity 2003;71(1):196-204.
2002: Diego Laderach; Mojgan Movassagh; Anthony Johnson; Robert S Mittler; Anne Galy
4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells.
International immunology 2002;14(10):1155-67.
2002: Ryan A Wilcox; Andrei I Chapoval; Kevin Gorski; Mizuto Otsuji; Tae Kwang Shin; Dallas B Flies; Koji Tamada; Robert S Mittler; Haruo Tsuchiya; Drew M Pardoll; Lieping Chen
Cutting edge: Expression of functional CD137 receptor by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4262-7.
2002: Linda Diehl; Geertje J D van Mierlo; Annemieke Th den Boer; Ellen I H van der Voort; Marieke F Fransen; Liesbeth van Bostelen; Paul Krimpenfort; Cornelis J M Melief; Robert S Mittler; René E M Toes; Rienk Offringa
In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3755-62.
2001: C Takahashi; Robert S Mittler; Anthony T Vella
Differential clonal expansion of CD4 and CD8 T cells in response to 4-1BB ligation: contribution of 4-1BB during inflammatory responses.
Immunology letters 2001;76(3):183-91.
2000: Joyce T Tan; Jongwon Ha; Hong Rae Cho; Carol Tucker-Burden; Rose Hendrix; Robert S Mittler; Thomas C Pearson; Christian P Larsen
Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.
Transplantation 2000;70(1):175-83.
2000: Shu-Hsia Chen; KB Pham-Nguyen; Olivier Martinet; Y Huang; W Yang; Swan N Thung; Li Chen; Robert S Mittler; Savio L C Woo
Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(1):39-46.
2000: Joyce T Tan; Jason K Whitmire; Kaja Murali-Krishna; Rafi Ahmed; John D Altman; Robert S Mittler; Alessandro Sette; Thomas C Pearson; Christian P Larsen
4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2320-5.
1999: Robert S Mittler; T S Bailey; K Klussman; MD TrailSmith; Michael K Hoffmann
Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy.
The Journal of experimental medicine 1999;190(10):1535-40.
1999: Z q Wang; Harold W Horowitz; Thorsten W Orlikowsky; B I Hahn; V Trejo; Abhijit S Bapat; Robert S Mittler; RJ Rayanade; S Y Yang; Michael K Hoffmann
Polyspecific self-reactive antibodies in individuals infected with human immunodeficiency virus facilitate T cell deletion and inhibit costimulatory accessory cell function.
The Journal of infectious diseases 1999;180(4):1072-9.
1999: C Takahashi; Robert S Mittler; Anthony T Vella
Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5037-40.
1999: zhi-qin wang; Abhijit S Bapat; V Trejo; Thorsten W Orlikowsky; Robert S Mittler; Michael K Hoffmann
MHC class I molecules on CD4 T cells regulate receptor-mediated activation signals.
Cellular immunology 1999;193(1):108-14.
1998: I Melero; J V Johnston; W W Shufford; Robert S Mittler; L Chen
NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.
Cellular immunology 1998;190(2):167-72.
1998: Thorsten W Orlikowsky; Z Wang; A Dudhane; Robert S Mittler; V Trejo; Guenther E Dannecker; Dietrich Niethammer; Michael K Hoffmann
Elevated major histocompatibility complex class I expression protects T cells from antibody- and macrophage-mediated deletion.
Immunology 1998;95(3):437-42.
1998: I Melero; N Bach; Karl Erik Hellström; Alejandro Aruffo; Robert S Mittler; L Chen
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway.
European journal of immunology 1998;28(3):1116-21.
1997: WW Shuford; K Klussman; D D Tritchler; DT Loo; J Chalupny; Anthony W Siadak; T J Brown; John Emswiler; H Raecho; Christian P Larsen; Thomas C Pearson; Jeffrey A Ledbetter; Alejandro Aruffo; Robert S Mittler
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
The Journal of experimental medicine 1997;186(1):47-55.
1997: I Melero; WW Shuford; S A Newby; Alejandro Aruffo; Jeffrey A Ledbetter; Karl Erik Hellström; Robert S Mittler; L Chen
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.
Nature medicine 1997;3(6):682-5.
1997: DT Loo; N J Chalupny; J Bajorath; WW Shuford; Robert S Mittler; Alejandro Aruffo
Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB.
The Journal of biological chemistry 1997;272(10):6448-56.
1997: Jeffrey A Ledbetter; Joseph A Francisco; Clay B Siegall; L K Gilliland; Diane L Hollenbaugh; Alejandro Aruffo; Anthony W Siadak; N Mischel-Petty; LS Grosmaire; M L Gordon; T J Brown; P Moran-Davis; Robert S Mittler; Peter Kiener; Steven G Nadler
Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.
Critical reviews in immunology 1997;17(5-6):427-35.
1996: K M Cabrian; K K Berry; W W Shuford; Robert S Mittler; J N Rodgers; Peter Linsley
Suppression of T-cell-dependent immune responses in monkeys by CTLA4Ig.
Transplantation proceedings 1996;28(6):3261-2.
1996: T J Brown; W W Shuford; W C Wang; Steven G Nadler; T S Bailey; H Marquardt; Robert S Mittler
Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells.
The Journal of biological chemistry 1996;271(44):27686-95.
1996: G Winberg; LS Grosmaire; K Klussman; MS Hayden; H P Fell; Jeffrey A Ledbetter; Robert S Mittler
Surface expression of CD28 single chain Fv for costimulation by tumor cells.
Immunological reviews 1996;153():209-23.
1996: MS Hayden; LS Grosmaire; N A Norris; L K Gilliland; G Winberg; D Tritschler; T T Tsu; Peter Linsley; Robert S Mittler; Peter D Senter; H P Fell; Jeffrey A Ledbetter
Costimulation by CD28 sFv expressed on the tumor cell surface or as a soluble bispecific molecule targeted to the L6 carcinoma antigen.
Tissue antigens 1996;48(4 Pt 1):242-54.
1996: Peter Linsley; J Bradshaw; J Greene; Robert Peach; KL Bennett; Robert S Mittler
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.
Immunity 1996;4(6):535-43.
1996: Dario A A Vignali; RT Carson; B Chang; Robert S Mittler; Jack L Strominger
The two membrane proximal domains of CD4 interact with the T cell receptor.
The Journal of experimental medicine 1996;183(5):2097-107.
1996: L K Gilliland; N A Norris; H Marquardt; T T Tsu; MS Hayden; M G Neubauer; D E Yelton; Robert S Mittler; Jeffrey A Ledbetter
Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments.
Tissue antigens 1996;47(1):1-20.
1994: G L Schieven; Robert S Mittler; Steven G Nadler; J M Kirihara; J B Bolen; Steven B Kanner; Jeffrey A Ledbetter
ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.
The Journal of biological chemistry 1994;269(32):20718-26.
1994: zhi-qin wang; Thorsten W Orlikowsky; A Dudhane; Robert S Mittler; M Blum; Elizabeth Lacy; G Riethmüller; Michael K Hoffmann
Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV-gp120 and gp120-specific antibodies from AIDS patients.
European journal of immunology 1994;24(7):1553-7.
1994: Robert S Mittler; G L Schieven; P M Dubois; K Klussman; M P O'Connell; Peter Kiener; V Herndon
CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):84-96.
1993: B M Rankin; S A Yocum; Robert S Mittler; Peter Kiener
Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):605-16.
1992: T L Collins; S Uniyal; J Shin; Jack L Strominger; Robert S Mittler; Steven J Burakoff
p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2159-62.
1991: Robert S Mittler; B M Rankin; Peter Kiener
Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3434-40.
1990: Robert S Mittler; C A Fifer; P Burbach; K Edinger; Peter Kiener
Evidence for a new HLA determinant that causes T cell activation without costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(3):794-803.
1990: S Mecheri; Michael Edidin; Guenther E Dannecker; Robert S Mittler; Michael K Hoffmann
Immunogenic Ia-binding peptides immobilize the Ia molecule and facilitate its aggregation on the B cell membrane. Control by the M1s-1 gene.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1361-8.
1989: Robert S Mittler; S J Goldman; G L Spitalny; S J Burakoff
T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8531-5.
1989: Robert S Mittler; Michael K Hoffmann
Synergism between HIV gp120 and gp120-specific antibody in blocking human T cell activation.
Science (New York, N.Y.) 1989;245(4924):1380-2.
1989: Peter Kiener; Robert S Mittler
CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):23-8.
1987: Robert S Mittler; R S Greenfield; B Z Schacter; N F Richard; Michael K Hoffmann
Antibodies to the common leukocyte antigen (T200) inhibit an early phase in the activation of resting human B cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(10):3159-66.
1985: Robert S Mittler; P Rao; G Olini; E Westberg; W Newman; M Hoffmann; G Goldstein
Activated human B cells display a functional IL 2 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(4):2393-9.
1984: D M Knowles; B Tolidjian; C C Marboe; Robert S Mittler; M A Talle; G Goldstein
Distribution of antigens defined by OKB monoclonal antibodies on benign and malignant lymphoid cells and on nonlymphoid tissues.
Blood 1984;63(4):886-96.
1983: Robert S Mittler; M A Talle; K Carpenter; P E Rao; G Goldstein
Generation and characterization of monoclonal antibodies reactive with human B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(4):1754-61.
1983: Robert S Mittler; P E Rao; M A Talle; R Look; G Goldstein
Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens.
The Journal of experimental medicine 1983;158(1):99-111.
1983: M A Talle; P E Rao; E Westberg; N Allegar; M Makowski; Robert S Mittler; G Goldstein
Patterns of antigenic expression on human monocytes as defined by monoclonal antibodies.
Cellular immunology 1983;78(1):83-99.
1983: Robert S Mittler; R Look; B Sheffler; M A Talle; P E Rao; G Goldstein
Resting and activation antigens of T cells: studies with OKT10 and OKT20 monoclonal antibodies.
Diagnostic immunology 1983;1(3):120-8.
1983: D M Knowles; L D Dodson; R Raab; Robert S Mittler; M A Talle; G Goldstein
The application of monoclonal antibodies to the characterization and diagnosis of lymphoid neoplasms: a review of recent studies.
Diagnostic immunology 1983;1(3):142-9.
1983: Alison Estabrook; Robert S Mittler; P LoGerfo; M Hardy; R L Edelson; C L Berger
Antigenic modulation of pan-T-cell and T-cell subset-specific markers.
Diagnostic immunology 1983;1(3):199-204.
1983: M A Talle; N Allegar; M Makowski; P E Rao; Robert S Mittler; G Goldstein
Classification of human lymphocytes and monocytes with the OK series of monoclonal antibodies.
Diagnostic immunology 1983;1(3):129-35.
1982: Michael K Hoffmann; S Pollack; Susan E Krown; Robert S Mittler
Deletion of active human suppressor T lymphocytes from peripheral blood by Sephadex G-10 filtration.
Journal of immunological methods 1982;55(3):327-36.
1982: E Fernández-Repollet; Robert S Mittler; S Tiffany; A Schwartz
In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1982;30(5):466-70.
1981: I Nachamkin; Janne Cannon; Robert S Mittler
Monoclonal antibodies against Neisseria gonorrhoeae: production of antibodies directed against a strain-specific cell surface antigen.
Infection and immunity 1981;32(2):641-8.
1979: M K Hoffmann; S Koenig; Robert S Mittler; H F Oettgen; P Ralph; C Galanos; Ulrich Hammerling
Macrophage factor controlling differentiation of B cells.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(2):497-502.
1978: M K Hoffmann; H F Oettgen; Lloyd J Old; Robert S Mittler; Ulrich Hammerling
Induction and immunological properties of tumor necrosis factor.
Journal of the Reticuloendothelial Society 1978;23(4):307-19.