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Sibylle Mittnacht

Research Profile

Chemicals & Drugs

Phenomena

Living Beings

Human Herpesvirus 8

Anatomy

Tumor Cells, Cultured

Concepts & Ideas

Physiology

Enzyme Activation

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Publications

TOP 3
Ekaterina P Lamber; Edward P Morris; Dmitri I Svergun; Fabienne Beuron; Sibylle Mittnacht
Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein.
Georgia Zoumpoulidou; George Thomas; Demelza Bird; Cristina Broceño; He Li; Sibylle Mittnacht
Role of the tripartite motif protein 27 in cancer development.
Elizabeth Richardson; Simon Stockwell; Wynne Aherne; Maria Emanuela Cuomo; He Li; Sibylle Mittnacht
Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.

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All Publications

2013: Ekaterina P Lamber; Edward P Morris; Dmitri I Svergun; Fabienne Beuron; Sibylle Mittnacht
Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein.
PloS one 2013;8(3):e58463.
2012: Georgia Zoumpoulidou; George Thomas; Demelza Bird; Cristina Broceño; He Li; Sibylle Mittnacht
Role of the tripartite motif protein 27 in cancer development.
Journal of the National Cancer Institute 2012;104(12):941-52.
2012: Elizabeth Richardson; Simon Stockwell; Wynne Aherne; Maria Emanuela Cuomo; He Li; Sibylle Mittnacht
Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.
PloS one 2012;7(2):e31627.
2012: Simon Stockwell; Robert H Te Poele; Mathilde Venet; Stuart C Wilson; Paul Workman; Georgia Zoumpoulidou; G Wynne Aherne; S Elaine Barrie; Julian Blagg; Frédéric Elustondo; Michelle D Garrett; Edward McDonald; Georgina Platt; Laurent Rigoreau; Peter Sheldrake; Christelle Soudy; Sibylle Mittnacht
Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
PloS one 2012;7(1):e28568.
2011: Maria Emanuela Cuomo; Georgina M Platt; Laurence H Pearl; Sibylle Mittnacht
Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition.
The Journal of biological chemistry 2011;286(11):9713-25.
2008: Francisco Sánchez-Sánchez; Sibylle Mittnacht
Nonsense-mediated decay: paving the road for genome diversification.
BioEssays : news and reviews in molecular, cellular and developmental biology 2008;30(10):926-8.
2008: Maria Emanuela Cuomo; Axel Knebel; Nick Morrice; Hugh Paterson; Philip Cohen; Sibylle Mittnacht
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation.
Nature cell biology 2008;10(6):723-30.
2007: Markus Hassler; Shradha Singh; Wyatt W Yue; Maciej Luczynski; Rachid Lakbir; Francisco Sanchez-Sanchez; Thomas Bader; Laurence H Pearl; Sibylle Mittnacht
Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.
Molecular cell 2007;28(3):371-85.
2007: Francisco Sánchez-Sánchez; Carmen Ramírez-Castillejo; Daniel B Weekes; Magdalena Beneyto; Félix Prieto; Carmen Nájera; Sibylle Mittnacht
Attenuation of disease phenotype through alternative translation initiation in low-penetrance retinoblastoma.
Human mutation 2007;28(2):159-67.
2006: Antony Oliver; Angela Paul; Kathy Boxall; S Elaine Barrie; G Wynne Aherne; Michelle D Garrett; Sibylle Mittnacht; Laurence H Pearl
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
The EMBO journal 2006;25(13):3179-90.
2006: Michele Vietri; Mariarita Bianchi; John W Ludlow; Sibylle Mittnacht; Emma Villa-Moruzzi
Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb.
Cancer cell international 2006;6():3.
2005: Maria Emanuela Cuomo; Axel Knebel; Georgina Platt; Nick Morrice; Philip Cohen; Sibylle Mittnacht
Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon.
The Journal of biological chemistry 2005;280(43):35844-58.
2005: Maja Krützfeldt; Mark Ellis; Daniel B Weekes; Jonathan J Bull; Martin Eilers; Maria d M Vivanco; William R Sellers; Sibylle Mittnacht
Selective ablation of retinoblastoma protein function by the RET finger protein.
Molecular cell 2005;18(2):213-24.
2005: Sibylle Mittnacht
The retinoblastoma protein--from bench to bedside.
European journal of cell biology 2005;84(2-3):97-107.
2005: Francisco Sánchez-Sánchez; Maja Kruetzfeldt; Carmen Nájera; Sibylle Mittnacht
A novel constitutional mutation affecting splicing of retinoblastoma tumor suppressor gene intron 23 causes partial loss of pRB activity.
Human mutation 2005;25(2):223.
2003: S Elaine Barrie; Ebun Eno-Amooquaye; Anthea Hardcastle; Georgina Platt; Juliet Richards; David Bedford; Paul Workman; Wynne Aherne; Sibylle Mittnacht; Michelle D Garrett
High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.
Analytical biochemistry 2003;320(1):66-74.
2003: Bing Xiao; James Spencer; Adrienne Clements; Nadeem Ali-Khan; Sibylle Mittnacht; Cristina Broceño; Manfred Burghammer; Anastassis Perraks; Ronen Marmorstein; Steven J Gamblin
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2363-8.
2002: Cristina Broceño; Scott Wilkie; Sibylle Mittnacht
RB activation defect in tumor cell lines.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14200-5.
2002: Georgina Platt; Antonino Carbone; Sibylle Mittnacht
p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma.
Oncogene 2002;21(12):1823-31.
2000: Georgina Platt; E Cannell; M E Cuomo; S Singh; Sibylle Mittnacht
Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines.
Virology 2000;272(2):257-66.
1999: Georgina Platt; Guy R Simpson; Sibylle Mittnacht; Thomas F Schulz
Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) gene.
Journal of virology 1999;73(12):9789-95.
1999: E Cannell; Sibylle Mittnacht
Viral encoded cyclins.
Seminars in cancer biology 1999;9(3):221-9.
1999: Mark Ellis; Y P Chew; L Fallis; S Freddersdorf; C Boshoff; Robin A Weiss; X Lu; Sibylle Mittnacht
Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.
The EMBO journal 1999;18(3):644-53.
1998: Y P Chew; Mark Ellis; S Wilkie; Sibylle Mittnacht
pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.
Oncogene 1998;17(17):2177-86.
1998: Sibylle Mittnacht
Control of pRB phosphorylation.
Current opinion in genetics & development 1998;8(1):21-7.
1997: D Godden-Kent; S J Talbot; C Boshoff; Yuan Chang; Patrick S Moore; Robin A Weiss; Sibylle Mittnacht
The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1.
Journal of virology 1997;71(6):4193-8.
1997: T Zarkowska; Sibylle Mittnacht
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases.
The Journal of biological chemistry 1997;272(19):12738-46.
1997: T Zarkowska; S U; E Harlow; Sibylle Mittnacht
Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs.
Oncogene 1997;14(2):249-54.
1996: Yuan Chang; Patrick S Moore; Simon J Talbot; C H Boshoff; T Zarkowska; Hugh F Paterson; Robin A Weiss; Sibylle Mittnacht
Cyclin encoded by KS herpesvirus.
Nature 1996;382(6590):410.
1996: A Belbrahem; D Godden-Kent; Sibylle Mittnacht
Regulation and activity of the retinoblastoma protein family in growth factor-deprived and TGF(beta)-treated keratinocytes.
Experimental cell research 1996;225(2):286-93.
1995: P Steiner; A Philipp; J Lukas; D Godden-Kent; M Pagano; Sibylle Mittnacht; J Bartek; Martin Eilers
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.
The EMBO journal 1995;14(19):4814-26.