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Jun-ichiro Miyagawa

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Noriko Kitamura; Yoshiki Kusunoki; Masayuki Miuchi; Jun-ichiro Miyagawa; Kazuki Murai; Tomoya Hamaguchi; Tomoyuki Katsuno; Fumihiro Ochi; Masaru Tokuda; Mitsuyoshi Namba
[Case report: A case of deep coma with early diagnosed myxedema].
Jun-ichiro Miyagawa; Masayuki Miuchi; Mitsuyoshi Namba
[Incretin-based therapy in patients with type 1 diabetes mellitus].
Hiroyuki Konya; Yoshikazu Hasegawa; Tomoya Hamaguchi; Kahori Satani; Akiko Umehara; Tomoyuki Katsuno; Tetsuya Ishikawa; Masayuki Miuchi; Kousuke Kohri; Akira Suehiro; Eizo Kakishita; Jun-ichiro Miyagawa; Mitsuyoshi Namba
Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus.

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All Publications

2012: Noriko Kitamura; Yoshiki Kusunoki; Masayuki Miuchi; Jun-ichiro Miyagawa; Kazuki Murai; Tomoya Hamaguchi; Tomoyuki Katsuno; Fumihiro Ochi; Masaru Tokuda; Mitsuyoshi Namba
[Case report: A case of deep coma with early diagnosed myxedema].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(4):1066-8.
2011: Jun-ichiro Miyagawa; Masayuki Miuchi; Mitsuyoshi Namba
[Incretin-based therapy in patients with type 1 diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(5):923-9.
2010: Hiroyuki Konya; Yoshikazu Hasegawa; Tomoya Hamaguchi; Kahori Satani; Akiko Umehara; Tomoyuki Katsuno; Tetsuya Ishikawa; Masayuki Miuchi; Kousuke Kohri; Akira Suehiro; Eizo Kakishita; Jun-ichiro Miyagawa; Mitsuyoshi Namba
Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2010;59(9):1294-9.
2009: Hiroyuki Konya; M Miuchi; K Konishi; E Nagai; T Ueyama; Y Kusunoki; Y Kimura; Y Nakamura; T Ishikawa; C Inokuchi; T Katsuno; Tomoya Hamaguchi; Jun-ichiro Miyagawa; Mitsuyoshi Namba
Pleiotropic effects of mitiglinide in type 2 diabetes mellitus.
The Journal of international medical research 2009;37(6):1904-12.
2009: Yukiyoshi Okauchi; Takao Nammo; Hiromi Iwahashi; Takashi Kizu; Isao Hayashi; Kohei Okita; Kazuya Yamagata; Sae Uno; Fumie Katsube; Munehide Matsuhisa; Ken Kato; Katsuyuki Aozasa; Tonsok Kim; Keigo Osuga; Shoji Nakamori; Yasuhiro Tamaki; Tohru Funahashi; Jun-ichiro Miyagawa; Iichiro Shimomura
Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
Internal medicine (Tokyo, Japan) 2009;48(12):1025-30.
2008: Yukiyoshi Okauchi; Hiromi Iwahashi; Kohei Okita; Ming Yuan; Morihiro Matsuda; Toshiya Tanaka; Jun-ichiro Miyagawa; Tohru Funahashi; Yukio Horikawa; Iichiro Shimomura; Kazuya Yamagata
PGC-1alpha Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men.
Endocrine journal 2008;55(6):991-7.
2008: Yoko Murayama; Yasuhisa Shinomura; Kenji Oritani; Jun-ichiro Miyagawa; Hitoshi Yoshida; Makoto Nishida; Fumie Katsube; Masamichi Shiraga; Tamana Miyazaki; Taisei Nakamoto; Shusaku Tsutsui; Shinji Tamura; Shigeki Higashiyama; Iichirou Shimomura; Norio Hayashi
The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells.
Journal of cellular physiology 2008;216(1):135-43.
2008: Ayumi Tokunaga; Atsuko Miura; Yukiyoshi Okauchi; Katsumori Segawa; Atsunori Fukuhara; Kohei Okita; Masahiko Takahashi; Tohru Funahashi; Jun-ichiro Miyagawa; Iichiro Shimomura; Kazuya Yamagata
The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects.
Endocrine journal 2008;55(1):205-12.
2008: Takao Nammo; Kazuya Yamagata; Toshiya Tanaka; Tatsuhiko Kodama; Frances M Sladek; Kenji Fukui; Fumie Katsube; Yoshifumi Sato; Jun-ichiro Miyagawa; Iichiro Shimomura
Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.
Gene expression patterns : GEP 2008;8(2):96-106.
2008: Tomomi Fujisawa; Hiroshi Ikegami; Soji Kasayama; Munehide Matsuhisa; Yoshimitsu Yamasaki; Jun-ichiro Miyagawa; Tohru Funahashi; Iichiro Shimomura
Age-dependent difference in factors affecting choice of system for self-monitoring of blood glucose.
Diabetes research and clinical practice 2008;79(1):103-7.
2007: Jun Zhang; Yae Tokui; Kazuya Yamagata; Junji Kozawa; Kouichi Sayama; Hiromi Iwahashi; Kohei Okita; M Miuchi; Hiroyuki Konya; T Hamaguchi; Mitsuyoshi Namba; Iichiro Shimomura; Jun-ichiro Miyagawa
Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.
Diabetologia 2007;50(9):1900-9.
2007: S Uno; Akihisa Imagawa; Kohei Okita; Kouichi Sayama; Makoto Moriwaki; Hiromi Iwahashi; Kazuya Yamagata; Shinji Tamura; Yuji Matsuzawa; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Iichiro Shimomura
Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetes.
Diabetologia 2007;50(3):596-601.
2006: Yae Tokui; Junji Kozawa; Kazuya Yamagata; Jun Zhang; Hiroshi Ohmoto; Yoshihiro Tochino; Kohei Okita; Hiromi Iwahashi; Mitsuyoshi Namba; Iichiro Shimomura; Jun-ichiro Miyagawa
Neogenesis and proliferation of beta-cells induced by human betacellulin gene transduction via retrograde pancreatic duct injection of an adenovirus vector.
Biochemical and biophysical research communications 2006;350(4):987-93.
2006: Jun-ichiro Miyagawa; Tomoya Hamaguchi; Hiroyuki Konya; Mitsuyoshi Namba
[Glucagonoma].
Nihon rinsho. Japanese journal of clinical medicine 2006;Suppl 3():367-71.
2006: Atsuko Miura; Kazuya Yamagata; Masafumi Kakei; Hiroyasu Hatakeyama; Noriko Takahashi; Kenji Fukui; Takao Nammo; Kazue Yoneda; Yusuke Inoue; Frances M Sladek; Mark Magnuson; Haruo Kasai; Jun-ichiro Miyagawa; Frank J Gonzalez; Iichiro Shimomura
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
The Journal of biological chemistry 2006;281(8):5246-57.
2005: Kenji Fukui; Qin Yang; Yang Cao; Noriko Takahashi; Hiroyasu Hatakeyama; Haiyan Wang; Jun Wada; Yanling Zhang; Lorella Marselli; Takao Nammo; Kazue Yoneda; Mineki Onishi; Shigeki Higashiyama; Yuji Matsuzawa; Frank J Gonzalez; Gordon C Weir; Haruo Kasai; Iichiro Shimomura; Jun-ichiro Miyagawa; Claes B Wollheim; Kazuya Yamagata
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.
Cell metabolism 2005;2(6):373-84.
2005: Yumiko Nakagawa-Toyama; Ken-ichi Hirano; Ken-ichi Tsujii; Makoto Nishida; Jun-ichiro Miyagawa; Naohiko Sakai; Shizuya Yamashita
Human scavenger receptor class B type I is expressed with cell-specific fashion in both initial and terminal site of reverse cholesterol transport.
Atherosclerosis 2005;183(1):75-83.
2005: Kouichi Sayama; Akihisa Imagawa; Kohei Okita; S Uno; Makoto Moriwaki; Junji Kozawa; Hiromi Iwahashi; Kazuya Yamagata; Shinji Tamura; Yuji Matsuzawa; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Iichiro Shimomura
Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment.
Diabetologia 2005;48(8):1560-4.
2005: Junji Kozawa; Yae Tokui; Makoto Moriwaki; Ming Li; Hiroshi Ohmoto; Ming Yuan; Jun Zhang; Hiromi Iwahashi; Akihisa Imagawa; Kazuya Yamagata; Yoshihiro Tochino; Iichiro Shimomura; Shigeki Higashiyama; Jun-ichiro Miyagawa
Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction through retrograde pancreatic duct injection of adenovirus vector.
Pancreas 2005;31(1):32-42.
2005: Kouichi Yamamoto; Tatsuya Kiyohara; Yoko Murayama; Shinji Kihara; Yoshihisa Okamoto; Tohru Funahashi; Takahito Ito; Riichiro Nezu; S Tsutsui; Jun-ichiro Miyagawa; Shinji Tamura; Yuji Matsuzawa; Iichiro Shimomura; Yasuhisa Shinomura
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.
Gut 2005;54(6):789-96.
2005: Aya Ihara; Kazuya Yamagata; Takao Nammo; Atsuko Miura; Ming Yuan; Toshiya Tanaka; Frances M Sladek; Yuji Matsuzawa; Jun-ichiro Miyagawa; Iichiro Shimomura
Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.
Biochemical and biophysical research communications 2005;329(3):984-90.
2005: Keitaro Yasuda; Youichi Saitoh; Kohei Okita; Shayne Morris; Makoto Moriwaki; Jun-ichiro Miyagawa; Toshiki Yoshimine
Giant intrasellar arachnoid cyst manifesting as adrenal insufficiency due to hypothalamic dysfunction--case report--.
Neurologia medico-chirurgica 2005;45(3):164-7.
2004: Yoko Murayama; Jun-ichiro Miyagawa; Kenji Oritani; Hitoshi Yoshida; Katsumi Yamamoto; Osamu Kishida; Tamana Miyazaki; Shusaku Tsutsui; Tatsuya Kiyohara; Yoshiji Miyazaki; Shigeki Higashiyama; Yuji Matsuzawa; Yasuhisa Shinomura
CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.
Journal of cell science 2004;117(Pt 15):3379-88.
2004: Shuhei Tomimoto; Hitoshi Hashimoto; Norihito Shintani; Kyohei Yamamoto; Yuki Kawabata; Ken-Ichi Hamagami; Kazuya Yamagata; Jun-ichiro Miyagawa; Akemichi Baba
Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice.
The Journal of pharmacology and experimental therapeutics 2004;309(2):796-803.
2003: Yoshihiro Kamada; Shinji Tamura; Shinichi Kiso; Hitoshi Matsumoto; Yukiko Saji; Yuichi Yoshida; Koji Fukui; Norikazu Maeda; Hitoshi Nishizawa; Hiroyuki Nagaretani; Yoshihisa Okamoto; Shinji Kihara; Jun-ichiro Miyagawa; Yasuhisa Shinomura; Tohru Funahashi; Yuji Matsuzawa
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.
Gastroenterology 2003;125(6):1796-807.
2003: Ming Li; Jun-ichiro Miyagawa; Makoto Moriwaki; Ming Yuan; Qin Yang; Junji Kozawa; Koji Yamamoto; Akihisa Imagawa; Hiromi Iwahashi; Yoshihiro Tochino; Kazuya Yamagata; Yuji Matsuzawa
Analysis of expression profiles of islet-associated transcription and growth factors during beta-cell neogenesis from duct cells in partially duct-ligated mice.
Pancreas 2003;27(4):345-55.
2003: Ken Kishida; Makoto Moriwaki; Jun-ichiro Miyagawa; Kohei Okita; Takashi Kondo; Kimiko Itoh; Satoshi Umemura; Junji Kozawa; Hiromi Iwahashi; Tohru Yoshizumi; Akihisa Imagawa; Kazuya Yamagata; Takao Maruyama; Hiroyuki Toyoshima; Eiji Kurokawa; Tohru Funahashi; Yuji Matsuzawa
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome.
Internal medicine (Tokyo, Japan) 2003;42(10):996-1005.
2003: Hiromi Iwahashi; Tohru Funahashi; Nobuo Kurokawa; Kouichi Sayama; E Fukuda; K Okita; Akihisa Imagawa; Kazuya Yamagata; Iichiro Shimomura; Jun-ichiro Miyagawa; Yuji Matsuzawa
Plasma adiponectin levels in women with anorexia nervosa.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(9):537-40.
2003: Y Horikawa; Tomoyuki Yamasaki; Hiromu Nakajima; R Shingu; Issei Yoshiuchi; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Identification of a novel variant in the phosphoenolpyruvate carboxykinase gene promoter in Japanese patients with type 2 diabetes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(5):308-12.
2003: Kyohei Yamamoto; Hitoshi Hashimoto; Shuhei Tomimoto; Norihito Shintani; Jun-ichi Miyazaki; Fumi Tashiro; Hiroyuki Aihara; Takao Nammo; Ming Li; Kazuya Yamagata; Jun-ichiro Miyagawa; Yuji Matsuzawa; Yuki Kawabata; Yuji Fukuyama; Kazumi Koga; Wakaba Mori; Kazuhiro Tanaka; Toshio Matsuda; Akemichi Baba
Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.
Diabetes 2003;52(5):1155-62.
2003: Qian Zhu; Kazuya Yamagata; Atsuko Miura; N Shihara; Y Horikawa; Jun Takeda; Jun-ichiro Miyagawa; Yuji Matsuzawa
T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects.
Diabetologia 2003;46(4):567-73.
2003: Shinichi Kiso; Sumio Kawata; Shinji Tamura; Yoshiaki Inui; Yuichi Yoshida; Yoshiyuki Sawai; Shinobu Umeki; Nobuyuki Ito; Akira Yamada; Jun-ichiro Miyagawa; Shigeki Higashiyama; Takao Iwawaki; Michiko Saito; Naoyuki Taniguchi; Yuji Matsuzawa; Kenji Kohno
Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy.
Gastroenterology 2003;124(3):701-7.
2003: Tatsuya Kiyohara; Yasuhisa Shinomura; Koji Isozaki; Masanori Nakahara; Shusaku Tsutsui; Hiroyuki Nishibayashi; Yoshiji Miyazaki; Jun-ichiro Miyagawa; Yuji Matsuzawa
A decreased number of c- kit-expressing cells in a patient with afferent loop syndrome.
Journal of gastroenterology 2003;38(4):390-4.
2002: Ming Li; Jun-ichiro Miyagawa; Koji Yamamoto; Makoto Moriwaki; Akihisa Imagawa; Hiromi Iwahashi; Kazuya Yamagata; Yoshihiro Tochino; Toshiaki Hanafusa; Yuji Matsuzawa
Beta cell neogenesis from ducts and phenotypic conversion of residual islet cells in the adult pancreas of glucose intolerant mice induced by selective alloxan perfusion.
Endocrine journal 2002;49(5):561-72.
2002: Jun-ichiro Miyagawa
[Regenerative medicine in diabetes by beta cell therapy and promotion of beta cell growth and differentiation].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():643-9.
2002: Akihisa Imagawa; Tohru Funahashi; Tadashi Nakamura; Makoto Moriwaki; Sachiyo Tanaka; Hitoshi Nishizawa; Kouichi Sayama; Sae Uno; Hiromi Iwahashi; Kazuya Yamagata; Jun-ichiro Miyagawa; Yuji Matsuzawa
Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes.
Diabetes care 2002;25(9):1665-6.
2002: Takao Nammo; Kazuya Yamagata; R Hamaoka; Qian Zhu; T E Akiyama; Frank J Gonzalez; Jun-ichiro Miyagawa; Yuji Matsuzawa
Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas.
Diabetologia 2002;45(8):1142-53.
2002: Masanori Nakahara; Koji Isozaki; Seiichi Hirota; Jean-Marie Vanderwinden; Rena Takakura; Kazuo Kinoshita; Jun-ichiro Miyagawa; Hui Chen; Yoshiji Miyazaki; Tatsuya Kiyohara; Yasuhisa Shinomura; Yuji Matsuzawa
Deficiency of KIT-positive cells in the colon of patients with diabetes mellitus.
Journal of gastroenterology and hepatology 2002;17(6):666-70.
2002: Qin Yang; Kazuya Yamagata; Kenji Fukui; Yang Cao; Takao Nammo; Hiromi Iwahashi; Haiyan Wang; Itaru Matsumura; Toshiaki Hanafusa; Richard Bucala; Claes B Wollheim; Jun-ichiro Miyagawa; Yuji Matsuzawa
Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.
Diabetes 2002;51(6):1785-92.
2002: Shigeru Sakuda; Shinji Tamura; Akira Yamada; Jun-ichiro Miyagawa; Koji Yamamoto; Shinichi Kiso; Nobuyuki Ito; Shigeki Higashiyama; Naoyuki Taniguchi; Sumio Kawata; Yuji Matsuzawa
NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparin-binding epidermal growth factor-like growth factor.
Journal of hepatology 2002;36(4):527-33.
2002: Yoko Murayama; Jun-ichiro Miyagawa; Yasuhisa Shinomura; Shuji Kanayama; Koji Isozaki; Katsumi Yamamori; Hitoshi Mizuno; Shingo Ishiguro; Tatsuya Kiyohara; Yoshiji Miyazaki; Naoyuki Taniguchi; Shigeki Higashiyama; Yuji Matsuzawa
Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer.
International journal of cancer. Journal international du cancer 2002;98(4):505-13.
2002: Hiromi Iwahashi; Kazuya Yamagata; Issei Yoshiuchi; Jungo Terasaki; Qin Yang; Kenji Fukui; Aya Ihara; Qian Zhu; Takeshi Asakura; Yang Cao; Akihisa Imagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Yuji Matsuzawa
Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha.
Diabetes 2002;51(4):910-4.
2002: Shigeru Sakuda; Shinji Tamura; Akira Yamada; Jun-ichiro Miyagawa; Koji Yamamoto; Shinichi Kiso; Nobuyuki Ito; Kazuho Imanaka; Akira Wada; Tetsuji Naka; Tadamitsu Kishimoto; Sumio Kawata; Yuji Matsuzawa
Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats.
Journal of hepatology 2002;36(3):378-84.
2002: Katsumi Iizuka; Hiromu Nakajima; Mitsuyoshi Namba; Jun-ichiro Miyagawa; Junichi Miyazaki; Toshiaki Hanafusa; Yuji Matsuzawa
Metabolic consequence of long-term exposure of pancreatic beta cells to free fatty acid with special reference to glucose insensitivity.
Biochimica et biophysica acta 2002;1586(1):23-31.
2002: Issei Yoshiuchi; Kazuya Yamagata; Qian Zhu; I Tamada; Y Takahashi; K Onigata; Jun Takeda; Jun-ichiro Miyagawa; Yuji Matsuzawa
Identification of a gain-of-function mutation in the HNF-1beta gene in a Japanese family with MODY.
Diabetologia 2002;45(1):154-5.
2002: Kazuya Yamagata; Takao Nammo; Makoto Moriwaki; Aya Ihara; Katsumi Iizuka; Qin Yang; Tomomi Satoh; Ming Li; Rikako Uenaka; Kohei Okita; Hiromi Iwahashi; Qian Zhu; Yang Cao; Akihisa Imagawa; Yoshihiro Tochino; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Yuji Matsuzawa
Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.
Diabetes 2002;51(1):114-23.
2001: Zhongyan Zhang; Shizuya Yamashita; Kenichi Hirano; Yumiko Nakagawa-Toyama; Akifumi Matsuyama; Makoto Nishida; Norio Sakai; M Fukasawa; H Arai; Jun-ichiro Miyagawa; Yuji Matsuzawa
Expression of cholesteryl ester transfer protein in human atherosclerotic lesions and its implication in reverse cholesterol transport.
Atherosclerosis 2001;159(1):67-75.
2001: Yumiko Nakagawa-Toyama; Shizuya Yamashita; Jun-ichiro Miyagawa; Makoto Nishida; S Nozaki; Hiroyuki Nagaretani; Norio Sakai; Hisatoyo Hiraoka; Katsumi Yamamori; T Yamane; Kenichi Hirano; Yuji Matsuzawa
Localization of CD36 and scavenger receptor class A in human coronary arteries--a possible difference in the contribution of both receptors to plaque formation.
Atherosclerosis 2001;156(2):297-305.
2001: Akihisa Imagawa; Toshiaki Hanafusa; Shinji Tamura; Makoto Moriwaki; N Itoh; Kazuhiro Yamamoto; Hiromi Iwahashi; Kazuya Yamagata; M Waguri; T Nanmo; S Uno; Hiromu Nakajima; Mitsuyoshi Namba; Sumio Kawata; Jun-ichiro Miyagawa; Yuji Matsuzawa
Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity.
Diabetes 2001;50(6):1269-73.
2001: R Tamura; Jun-ichiro Miyagawa; Makoto Nishida; Shinji Kihara; R Sasada; K Igarashi; A Nakata; Katsumi Yamamori; K Kameda-Takemura; Shizuya Yamashita; Yuji Matsuzawa
Immunohistochemical localization of Betacellulin, a member of epidermal growth factor family, in atherosclerotic plaques of human aorta.
Atherosclerosis 2001;155(2):413-23.
2000: Kazuhiro Yamamoto; Jun-ichiro Miyagawa; M Waguri; R Sasada; K Igarashi; Ming Li; Takao Nammo; Makoto Moriwaki; Akihisa Imagawa; Kazuya Yamagata; Hiromu Nakajima; Mitsuyoshi Namba; Yoshihiro Tochino; Toshiaki Hanafusa; Yuji Matsuzawa
Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.
Diabetes 2000;49(12):2021-7.
2000: Sho Tokumaru; Shigeki Higashiyama; T Endo; T Nakagawa; Jun-ichiro Miyagawa; Katsumi Yamamori; Y Hanakawa; Hiroshi Ohmoto; K Yoshino; Y Shirakata; Yuji Matsuzawa; K Hashimoto; Naoyuki Taniguchi
Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing.
The Journal of cell biology 2000;151(2):209-20.
2000: M Sugimachi; Tatsuya Kiyohara; Y Murayama; T Minami; Yoshiji Miyazaki; Jun-ichiro Miyagawa; Yasuhisa Shinomura; Yuji Matsuzawa
Endogenous endothelin in a rat model of acute colonic mucosal injury.
Journal of gastroenterology and hepatology 2000;15(10):1125-31.
2000: Qian Zhu; Kazuya Yamagata; L Yu; Hideaki Tomura; S Yamada; Qin Yang; Issei Yoshiuchi; S Sumi; Jun-ichiro Miyagawa; Jun Takeda; Toshiaki Hanafusa; Yuji Matsuzawa
Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus.
Diabetologia 2000;43(9):1197-200.
2000: Hitoshi Yoshida; Yoshiaki Tomiyama; Jun Ishikawa; Kenji Oritani; Itaru Matsumura; Masamichi Shiraga; Takashi Yokota; Y Okajima; Minetaro Ogawa; Jun-ichiro Miyagawa; Tetsuo Nishiura; Yuji Matsuzawa
Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42.
Blood 2000;96(1):234-41.
2000: N Sawada-Hase; Tatsuya Kiyohara; Jun-ichiro Miyagawa; H Ueyama; Hiroyuki Nishibayashi; Yoko Murayama; T Kashihara; Masanori Nakahara; Yuji Miyazaki; Shuji Kanayama; Riichiro Nezu; Yasuhisa Shinomura; Yuji Matsuzawa
An increased number of CD40-high monocytes in patients with Crohn's disease.
The American journal of gastroenterology 2000;95(6):1516-23.
2000: Makoto Nishida; Jun-ichiro Miyagawa; Shizuya Yamashita; Shigeki Higashiyama; A Nakata; Noriyuki Ouchi; R Tamura; Katsumi Yamamori; Shinji Kihara; Naoyuki Taniguchi; Yuji Matsuzawa
Localization of CD9, an enhancer protein for proheparin-binding epidermal growth factor-like growth factor, in human atherosclerotic plaques: possible involvement of juxtacrine growth mechanism on smooth muscle cell proliferation.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(5):1236-43.
2000: Qin Yang; Kazuya Yamagata; Kazuhiro Yamamoto; Yang Cao; Jun-ichiro Miyagawa; A Fukamizu; Toshiaki Hanafusa; Yuji Matsuzawa
R127W-HNF-4alpha is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1.
Diabetologia 2000;43(4):520-4.
2000: K Iizuka; Hiromu Nakajima; A Ono; K Okita; J i Miyazaki; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Stable overexpression of the glucose-6-phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic beta-cell line.
The Journal of endocrinology 2000;164(3):307-14.
2000: Akihisa Imagawa; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Yuji Matsuzawa
A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group.
The New England journal of medicine 2000;342(5):301-7.
2000: Yoshihisa Okamoto; Yukio Arita; Makoto Nishida; Masahiro Muraguchi; Noriyuki Ouchi; Masahiko Takahashi; Takumi Igura; Yoshiaki Inui; Shinji Kihara; Tadashi Nakamura; Shizuya Yamashita; Jun-ichiro Miyagawa; Tohru Funahashi; Yuji Matsuzawa
An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(2):47-50.
1999: Qin Yang; Kazuya Yamagata; Kazuhiro Yamamoto; Jun-ichiro Miyagawa; Jun Takeda; N Iwasaki; Hiromi Iwahashi; Issei Yoshiuchi; Mitsuyoshi Namba; J i Miyazaki; Toshiaki Hanafusa; Yuji Matsuzawa
Structure/function studies of hepatocyte nuclear factor-1alpha, a diabetes-associated transcription factor.
Biochemical and biophysical research communications 1999;266(1):196-202.
1999: Jun-ichiro Miyagawa; O Hanafusa; R Sasada; Kazuhiro Yamamoto; K Igarashi; Katsumi Yamamori; Masaharu Seno; Hisato Tada; Takao Nammo; Ming Li; Kazuya Yamagata; Hiromu Nakajima; Mitsuyoshi Namba; Masamichi Kuwajima; Yuji Matsuzawa
Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells.
Endocrine journal 1999;46(6):755-64.
1999: Shinichi Kiso; Sumio Kawata; Shinji Tamura; Jun-ichiro Miyagawa; Nobuyuki Ito; H Tsushima; Akira Yamada; Shinobu Umeki; Shigeki Higashiyama; Naoyuki Taniguchi; Yuji Matsuzawa
Expression of heparin-binding epidermal growth factor-like growth factor in the hepatocytes of fibrotic rat liver during hepatocarcinogenesis.
Journal of gastroenterology and hepatology 1999;14(12):1203-9.
1999: Hideaki Kaneto; Yoshitaka Kajimoto; Jun-ichiro Miyagawa; T a Matsuoka; Yoshio Fujitani; Yutaka Umayahara; Toshiaki Hanafusa; Yuji Matsuzawa; Yoshimitsu Yamasaki; Masatsugu Hori
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Diabetes 1999;48(12):2398-406.
1999: Makoto Moriwaki; N Itoh; Jun-ichiro Miyagawa; Kazuhiro Yamamoto; Akihisa Imagawa; Kazuya Yamagata; Hiromi Iwahashi; Hiromu Nakajima; Mitsuyoshi Namba; S Nagata; Toshiaki Hanafusa; Yuji Matsuzawa
Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus.
Diabetologia 1999;42(11):1332-40.
1999: Yoko Murayama; Jun-ichiro Miyagawa; Yasuhisa Shinomura; Shuji Kanayama; Yuichi Yasunaga; Hiroyuki Nishibayashi; Katsumi Yamamori; Yuichiro Higashimoto; Yuji Matsuzawa
Morphological and functional restoration of parietal cells in helicobacter pylori associated enlarged fold gastritis after eradication.
Gut 1999;45(5):653-61.
1999: Kohei Okita; Qin Yang; Kazuya Yamagata; K A Hangenfeldt; Jun-ichiro Miyagawa; Yoshitaka Kajimoto; Hiromu Nakajima; Mitsuyoshi Namba; Claes B Wollheim; Toshiaki Hanafusa; Yuji Matsuzawa
Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.
Biochemical and biophysical research communications 1999;263(2):566-9.
1999: Kenichi Hirano; Shizuya Yamashita; Yasuhiko Nakagawa; T Ohya; Fumihiko Matsuura; Kosuke Tsukamoto; Yoshihisa Okamoto; Akifumi Matsuyama; Kunihiro Matsumoto; Jun-ichiro Miyagawa; Yuji Matsuzawa
Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions.
Circulation research 1999;85(1):108-16.
1999: R Hamaoka; Junichi Fujii; Jun-ichiro Miyagawa; Masahiko Takahashi; M Kishimoto; Makoto Moriwaki; K Yamamoto; Yoshitaka Kajimoto; Yoshimitsu Yamasaki; Toshiaki Hanafusa; Yuji Matsuzawa; Naoyuki Taniguchi
Overexpression of the aldose reductase gene induces apoptosis in pancreatic beta-cells by causing a redox imbalance.
Journal of biochemistry 1999;126(1):41-7.
1999: Shinichi Kiso; Sumio Kawata; Shinji Tamura; Shinobu Umeki; Nobuyuki Ito; H Tsushima; Akira Yamada; Jun-ichiro Miyagawa; Shigeki Higashiyama; Naoyuki Taniguchi; Yuji Matsuzawa
Effects of exogenous human heparin-binding epidermal growth factor-like growth factor on DNA synthesis of hepatocytes in normal mouse liver.
Biochemical and biophysical research communications 1999;259(3):683-7.
1999: Issei Yoshiuchi; Kazuya Yamagata; Qin Yang; Hiromi Iwahashi; Kohei Okita; Kazuhiro Yamamoto; T Oue; Akihisa Imagawa; T Hamaguchi; Tomoyuki Yamasaki; Y Horikawa; T Satoh; Hiromu Nakajima; J i Miyazaki; Shigeki Higashiyama; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.
Diabetologia 1999;42(5):621-6.
1999: Akihisa Imagawa; Toshiaki Hanafusa; N Itoh; M Waguri; Kazuhiro Yamamoto; Jun-ichiro Miyagawa; Makoto Moriwaki; Kazuya Yamagata; Hiromi Iwahashi; M Sada; T Tsuji; Shinji Tamura; Sumio Kawata; Masamichi Kuwajima; Hiromu Nakajima; Mitsuyoshi Namba; Yuji Matsuzawa
Immunological abnormalities in islets at diagnosis paralleled further deterioration of glycaemic control in patients with recent-onset Type I (insulin-dependent) diabetes mellitus.
Diabetologia 1999;42(5):574-8.
1999: A Nakata; Yasuhiko Nakagawa; Makoto Nishida; S Nozaki; Jun-ichiro Miyagawa; T Nakagawa; R Tamura; Kunihiro Matsumoto; K Kameda-Takemura; Shizuya Yamashita; Yuji Matsuzawa
CD36, a novel receptor for oxidized low-density lipoproteins, is highly expressed on lipid-laden macrophages in human atherosclerotic aorta.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1333-9.
1999: Yukio Arita; Shinji Kihara; Noriyuki Ouchi; Masahiko Takahashi; Kazuhisa Maeda; Jun-ichiro Miyagawa; Kikuko Hotta; Iichiro Shimomura; Tadashi Nakamura; K Miyaoka; Hiroshi Kuriyama; Makoto Nishida; Shizuya Yamashita; K Okubo; K Matsubara; Masahiro Muraguchi; Yasukazu Ohmoto; Tohru Funahashi; Yuji Matsuzawa
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Biochemical and biophysical research communications 1999;257(1):79-83.
1999: Jun-ichiro Miyagawa; Toshiaki Hanafusa
[Mechanism of atherosclerosis in diabetes: altered cytokine network in the vascular wall].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(3):601-6.
1999: T Nagase; Sumio Kawata; H Nakajima; Shinji Tamura; E Yamasaki; K Fukui; K Yamamoto; Jun-ichiro Miyagawa; Itaru Matsumura; Yasuo Matsuda; Yuji Matsuzawa
Effect of farnesyltransferase overexpression on cell growth and transformation.
International journal of cancer. Journal international du cancer 1999;80(1):126-33.
1999: R Hamaoka; Y Yaginuma; T Takahashi; Junichi Fujii; Masahiko Koizumi; HG Seo; Y Hatanaka; K Hashizume; K Ii; Jun-ichiro Miyagawa; Toshiaki Hanafusa; Yuji Matsuzawa; M Ishikawa; Naoyuki Taniguchi
Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers.
Journal of cancer research and clinical oncology 1999;125(6):321-6.
1998: Masanori Nakahara; Koji Isozaki; Seiichi Hirota; Jun-ichiro Miyagawa; N Hase-Sawada; Masahiko Taniguchi; Toshirou Nishida; Shuji Kanayama; Yukihiko Kitamura; Yasuhisa Shinomura; Yuji Matsuzawa
A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors.
Gastroenterology 1998;115(5):1090-5.
1998: Kazuya Yamagata; Qin Yang; Kazuhiro Yamamoto; Hiromi Iwahashi; Jun-ichiro Miyagawa; Kohei Okita; Issei Yoshiuchi; J i Miyazaki; T Noguchi; Hiromu Nakajima; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative.
Diabetes 1998;47(8):1231-5.
1998: H Ueyama; Tatsuya Kiyohara; N Sawada; Koji Isozaki; Shinji Kitamura; S Kondo; Jun-ichiro Miyagawa; Shuji Kanayama; Yasuhisa Shinomura; H Ishikawa; T Ohtani; Riichiro Nezu; S Nagata; Yuji Matsuzawa
High Fas ligand expression on lymphocytes in lesions of ulcerative colitis.
Gut 1998;43(1):48-55.
1998: Hiromi Iwahashi; N Itoh; Kazuya Yamagata; Akihisa Imagawa; Hiromu Nakajima; K Tomita; Makoto Moriwaki; M Waguri; Kazuhiro Yamamoto; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Molecular mechanisms of pancreatic beta-cell destruction in autoimmune diabetes: potential targets for preventive therapy.
Cytokines, cellular & molecular therapy 1998;4(1):45-51.
1998: Issei Yoshiuchi; R Shingu; Hiromu Nakajima; T Hamaguchi; Y Horikawa; Tomoyuki Yamasaki; T Oue; A Ono; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Mutation/polymorphism scanning of glucose-6-phosphatase gene promoter in noninsulin-dependent diabetes mellitus patients.
The Journal of clinical endocrinology and metabolism 1998;83(3):1016-9.
1997: Hideaki Kaneto; Jun-ichiro Miyagawa; Yoshitaka Kajimoto; Koji Yamamoto; Hirotaka Watada; Yutaka Umayahara; Toshiaki Hanafusa; Yuji Matsuzawa; Yoshimitsu Yamasaki; Shigeki Higashiyama; Naoyuki Taniguchi
Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation.
The Journal of biological chemistry 1997;272(46):29137-43.
1997: Shigeki Higashiyama; M Horikawa; Kiyofumi Yamada; N Ichino; N Nakano; Takatoshi Nakagawa; Jun-ichiro Miyagawa; N Matsushita; Toshiharu Nagatsu; Naoyuki Taniguchi; H Ishiguro
A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4.
Journal of biochemistry 1997;122(3):675-80.
1997: N Itoh; Akihisa Imagawa; Toshiaki Hanafusa; M Waguri; Kazuhiro Yamamoto; Hiromi Iwahashi; Makoto Moriwaki; Hiromu Nakajima; Jun-ichiro Miyagawa; Mitsuyoshi Namba; S Makino; Shigekazu Nagata; N Kono; Yuji Matsuzawa
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
The Journal of experimental medicine 1997;186(4):613-8.
1997: M Waguri; Kazuhiro Yamamoto; Jun-ichiro Miyagawa; Yoshihiro Tochino; Katsumi Yamamori; Yoshitaka Kajimoto; Hiromu Nakajima; Hirotaka Watada; Issei Yoshiuchi; N Itoh; Akihisa Imagawa; Mitsuyoshi Namba; Masamichi Kuwajima; Yoshimitsu Yamasaki; Toshiaki Hanafusa; Yuji Matsuzawa
Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan.
Diabetes 1997;46(8):1281-90.
1997: Shusaku Tsutsui; Yasuhisa Shinomura; Shigeki Higashiyama; Yuichiro Higashimoto; Yuji Miyazaki; Shuji Kanayama; Shuko Hiraoka; Takashi Minami; Shinji Kitamura; Yoko Murayama; Jun-ichiro Miyagawa; Naoyuki Taniguchi; Yuji Matsuzawa
Induction of heparin binding epidermal growth factor-like growth factor and amphiregulin mRNAs by gastrin in the rat stomach.
Biochemical and biophysical research communications 1997;235(3):520-3.
1997: Itaru Matsumura; Jun Ishikawa; Koichi Nakajima; Kenji Oritani; Yoshiaki Tomiyama; Jun-ichiro Miyagawa; Takayuki Kato; H Miyazaki; Yuji Matsuzawa; Yuzuru Kanakura
Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5.
Molecular and cellular biology 1997;17(5):2933-43.
1997: M Waguri; Toshiaki Hanafusa; N Itoh; Jun-ichiro Miyagawa; Akihisa Imagawa; Masamichi Kuwajima; N Kono; Yuji Matsuzawa
Histopathologic study of the pancreas shows a characteristic lymphocytic infiltration in Japanese patients with IDDM.
Endocrine journal 1997;44(1):23-33.
1997: Koji Isozaki; Seiichi Hirota; Jun-ichiro Miyagawa; Masahiko Taniguchi; Yasuhisa Shinomura; Yuji Matsuzawa
Deficiency of c-kit+ cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction.
The American journal of gastroenterology 1997;92(2):332-4.
1997: T Minami; Yasuhisa Shinomura; Jun-ichiro Miyagawa; H Tojo; M Okamoto; Yuji Matsuzawa
Immunohistochemical localization of group II phospholipase A2 in colonic mucosa of patients with inflammatory bowel disease.
The American journal of gastroenterology 1997;92(2):289-92.
1997: M Nishida; Jun-ichiro Miyagawa; K Tokunaga; K Yamamoto; Y Keno; T Kobatake; S Yoshida; T Nakamura; H Odaka; H Ikeda; T Hanafusa; S Yamashita; K Kameda-Takemura; Y Matsuzawa
Early morphologic changes of atherosclerosis induced by ventromedial hypothalamic lesion in the spontaneously diabetic Goto-Kakizaki rat.
The Journal of laboratory and clinical medicine 1997;129(2):200-7.
1997: T Nagase; Sumio Kawata; Shinji Tamura; Yasuo Matsuda; Yoshiaki Inui; E Yamasaki; H Ishiguro; T Ito; Jun-ichiro Miyagawa; H Mitsui; K Yamamoto; M Kinoshita; Yuji Matsuzawa
Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells.
British journal of cancer 1997;76(8):1001-10.
1996: S Kondo; Yasuhisa Shinomura; Shuji Kanayama; Yuichiro Higashimoto; Jun-ichiro Miyagawa; T Minami; Tatsuya Kiyohara; S Zushi; S Kitamura; Koji Isozaki; Yuji Matsuzawa
Over-expression of bcl-xL gene in human gastric adenomas and carcinomas.
International journal of cancer. Journal international du cancer 1996;68(6):727-30.
1996: Hiromu Nakajima; Issei Yoshiuchi; T Hamaguchi; K Tomita; Tomoyuki Yamasaki; K Iizuka; Kohei Okita; Makoto Moriwaki; A Ono; Takaharu Oue; Y Horikawa; R Shingu; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Hepatocyte nuclear factor-4 alpha gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients.
Research communications in molecular pathology and pharmacology 1996;94(3):327-30.
1996: Takumi Igura; Sumio Kawata; Jun-ichiro Miyagawa; Yoshiaki Inui; S Tamura; K Fukuda; Koji Isozaki; Katsumi Yamamori; Naoyuki Taniguchi; Shigeki Higashiyama; Yuji Matsuzawa
Expression of heparin-binding epidermal growth factor-like growth factor in neointimal cells induced by balloon injury in rat carotid arteries.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(12):1524-31.
1996: A Nakata; Jun-ichiro Miyagawa; S Yamashita; Makoto Nishida; R Tamura; Katsumi Yamamori; Tadashi Nakamura; S Nozaki; K Kameda-Takemura; Sumio Kawata; Naoyuki Taniguchi; Shigeki Higashiyama; Yuji Matsuzawa
Localization of heparin-binding epidermal growth factor-like growth factor in human coronary arteries. Possible roles of HB-EGF in the formation of coronary atherosclerosis.
Circulation 1996;94(11):2778-86.
1996: Hirotaka Watada; Yoshitaka Kajimoto; Jun-ichiro Miyagawa; Toshiaki Hanafusa; K Hamaguchi; T Matsuoka; K Yamamoto; Yuji Matsuzawa; R Kawamori; Yoshimitsu Yamasaki
PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin.
Diabetes 1996;45(12):1826-31.
1996: S Yoshida; S Yamashita; K Tokunaga; M Yamane; E Shinohara; Y Keno; Makoto Nishida; K Kotani; Iichiro Shimomura; H Kobayashi; Tadashi Nakamura; Jun-ichiro Miyagawa; K Kameda-Takemura; H Odaka; H Ikeda; Yuji Matsuzawa
Visceral fat accumulation and vascular complications associated with VMH lesioning of spontaneously non-insulin-dependent diabetic GK rat.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(10):909-16.
1996: K Yamagata; Hiromu Nakajima; K Tomita; N Itoh; Jun-ichiro Miyagawa; T Hamaguchi; Mitsuyoshi Namba; S Tamura; Sumio Kawata; Norio Kono; Masamichi Kuwajima; Toshihide Noguchi; Toshiaki Hanafusa; Yuji Matsuzawa
Dominant TCR alpha-chain clonotypes and interferon-gamma are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus.
Diabetes research and clinical practice 1996;34(1):37-46.
1996: R Shingu; Hiromu Nakajima; Y Horikawa; T Hamaguchi; Tomoyuki Yamasaki; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa
Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state.
Research communications in molecular pathology and pharmacology 1996;93(1):13-24.
1996: H Miki; Mitsuyoshi Namba; T Nishimura; I Mineo; T Matsumura; Jun-ichiro Miyagawa; Hiromu Nakajima; Masamichi Kuwajima; Toshiaki Hanafusa; Yuji Matsuzawa
Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes.
Biochimica et biophysica acta 1996;1312(2):132-6.
1996: Kikuko Hotta; Masamichi Kuwajima; A Ono; Hiromu Nakajima; Y Horikawa; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; M Horiuchi; H Nikaido; J Hayakawa; T Saheki; Norio Kono; Toshihide Noguchi; Yuji Matsuzawa
Disordered expression of glycolytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency.
Diabetes research and clinical practice 1996;32(3):117-23.
1996: Hiromi Iwahashi; Toshiaki Hanafusa; Y Eguchi; Hiromu Nakajima; Jun-ichiro Miyagawa; N Itoh; K Tomita; Mitsuyoshi Namba; Masamichi Kuwajima; Toshihide Noguchi; Yoshihide Tsujimoto; Yuji Matsuzawa
Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2.
Diabetologia 1996;39(5):530-6.
1996: Akihisa Imagawa; N Itoh; Toshiaki Hanafusa; H Katsura; A Yamaguchi; A Takeda; Hiromi Iwahashi; Hiromu Nakajima; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Masamichi Kuwajima; Yuji Matsuzawa
High prevalence of antibodies to glutamic acid decarboxylase in comparison to islet cell antibodies in patients with long-standing insulin-dependent diabetes mellitus.
Research communications in molecular pathology and pharmacology 1996;92(1):43-52.
1996: Yoshitaka Kajimoto; Jun-ichiro Miyagawa; K Ishihara; Y Okuyama; Yoshio Fujitani; M Itoh; H Yoshida; Tsuneyasu Kaisho; T Matsuoka; Hirotaka Watada; Toshiaki Hanafusa; Yoshimitsu Yamasaki; T Kamada; Yuji Matsuzawa; Toshio Hirano
Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity.
Biochemical and biophysical research communications 1996;219(3):941-6.
1996: Kikuko Hotta; Masamichi Kuwajima; A Ono; Hiromu Nakajima; R Shingu; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Toshihide Noguchi; Norio Kono; Yuji Matsuzawa
Disordered expression of hepatic glycolytic and gluconeogenic enzymes in Otsuka Long-Evans Tokushima fatty rats with spontanteous long-term hyperglycemia.
Biochimica et biophysica acta 1996;1289(1):145-9.
1996: Kikuko Hotta; Masamichi Kuwajima; A Ono; R Uenaka; Hiromu Nakajima; Jun-ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; M Horiuchi; H Nikaido; J Hayakawa; Norio Kono; T Saheki; Yuji Matsuzawa
Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis.
Biochimica et biophysica acta 1996;1289(1):131-5.
1996: T Ito; Sumio Kawata; S Tamura; Takumi Igura; T Nagase; Jun-ichiro Miyagawa; E Yamazaki; H Ishiguro; Y Matasuzawa
Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl:protein transferase inhibitor.
Japanese journal of cancer research : Gann 1996;87(2):113-6.
1995: Akihisa Imagawa; Hiromu Nakajima; N Itoh; Jun-ichiro Miyagawa; M Waguri; Y Horikawa; M Inada; S Tamura; Sumio Kawata; Masamichi Kuwajima
Mitochondrial DNA mutations in pancreatic biopsy specimens from IDDM patients.
Diabetes research and clinical practice 1995;30(2):79-87.
1995: S Nozaki; H Kashiwagi; S Yamashita; T Nakagawa; B Kostner; Yoshiaki Tomiyama; A Nakata; Masato Ishigami; Jun-ichiro Miyagawa; K Kameda-Takemura
Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects.
The Journal of clinical investigation 1995;96(4):1859-65.
1995: Yoko Murayama; Jun-ichiro Miyagawa; Shigeki Higashiyama; S Kondo; M Yabu; Koji Isozaki; Y Kayanoki; Shuji Kanayama; Yasuhisa Shinomura; Naoyuki Taniguchi
Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa.
Gastroenterology 1995;109(4):1051-9.
1995: Koji Isozaki; S Hirota; A Nakama; Jun-ichiro Miyagawa; Yasuhisa Shinomura; Z Xu; Shintaro Nomura; Y Kitamura
Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats.
Gastroenterology 1995;109(2):456-64.
1995: Akihisa Imagawa; N Itoh; Toshiaki Hanafusa; Y Oda; M Waguri; Jun-ichiro Miyagawa; Norio Kono; Masamichi Kuwajima; Yuji Matsuzawa
Autoimmune endocrine disease induced by recombinant interferon-alpha therapy for chronic active type C hepatitis.
The Journal of clinical endocrinology and metabolism 1995;80(3):922-6.
1995: Jun-ichiro Miyagawa; S Higashiyama; S Kawata; Y Inui; S Tamura; K Yamamoto; M Nishida; Tadashi Nakamura; S Yamashita; Yuji Matsuzawa
Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques.
The Journal of clinical investigation 1995;95(1):404-11.
1995: Jun-ichiro Miyagawa; Masamichi Kuwajima; Toshiaki Hanafusa; K Ozaki; Harutoshi Fujimura; A Ono; R Uenaka; I Narama; Takaharu Oue; K Yamamoto
Mitochondrial abnormalities of muscle tissue in mice with juvenile visceral steatosis associated with systemic carnitine deficiency.
Virchows Archiv : an international journal of pathology 1995;426(3):271-9.
1994: Yoshiaki Inui; Shigeki Higashiyama; Sumio Kawata; S Tamura; Jun-ichiro Miyagawa; Naoyuki Taniguchi; Yuji Matsuzawa
Expression of heparin-binding epidermal growth factor in human hepatocellular carcinoma.
Gastroenterology 1994;107(6):1799-804.
1994: Toshiaki Hanafusa; Jun-ichiro Miyagawa; Hiromu Nakajima; K Tomita; Masamichi Kuwajima; Yuji Matsuzawa; S Tarui
The NOD mouse.
Diabetes research and clinical practice 1994;24 Suppl():S307-11.
1994: M Waguri; Toshiaki Hanafusa; N Itoh; Akihisa Imagawa; Jun-ichiro Miyagawa; Sumio Kawata; Norio Kono; Masamichi Kuwajima; Yuji Matsuzawa
Occurrence of IDDM during interferon therapy for chronic viral hepatitis.
Diabetes research and clinical practice 1994;23(1):33-6.
1993: N Itoh; Toshiaki Hanafusa; A Miyazaki; Jun-ichiro Miyagawa; Kazuya Yamagata; K Yamamoto; M Waguri; Akihisa Imagawa; S Tamura; M Inada
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.
The Journal of clinical investigation 1993;92(5):2313-22.
1993: Y Oda; K Mashita; M Mori-Tanaka; K Kitajima; Jun-ichiro Miyagawa; K Tajima; Toshiaki Hanafusa; Norio Kono; Yuji Matsuzawa
The inhibitory effect of noradrenaline on thyrotrophin-stimulated 3,5,3'-tri-iodothyronine and thyroxine release is mediated through a Ca(2+)-dependent process in the thyroid gland of the mouse.
The Journal of endocrinology 1993;138(1):73-80.
1992: C Nakagawa; Toshiaki Hanafusa; Jun-ichiro Miyagawa; M Yutsudo; Hiromu Nakajima; K Yamamoto; K Tomita; Norio Kono; Akira Hakura; S Tarui
Retrovirus gag protein p30 in the islets of non-obese diabetic mice: relevance for pathogenesis of diabetes mellitus.
Diabetologia 1992;35(7):614-8.
1992: N Itoh; Toshiaki Hanafusa; Jun-ichiro Miyagawa; S Tamura; M Inada; S Kawata; Norio Kono; S Tarui
Transthyretin (prealbumin) in the pancreas and sera of newly diagnosed type I (insulin-dependent) diabetic patients.
The Journal of clinical endocrinology and metabolism 1992;74(6):1372-7.
1991: Y Oda; K Tajima; M Mori-Tanaka; I Matsui; K Kitajima; Jun-ichiro Miyagawa; Toshiaki Hanafusa; K Mashita; S Tarui
Alpha 1-adrenergic regulation of thyrotropin-stimulated release of 3, 5, 3' -triiodothyronine and thyroxine from perifused mouse thyroid.
Journal of endocrinological investigation 1991;14(10):867-73.
1991: Kazuya Yamagata; Toshiaki Hanafusa; Hiromu Nakajima; M Sada; H Amemiya; K Tomita; Jun-ichiro Miyagawa; Toshihide Noguchi; T Tanaka; Norio Kono
HLA-DP and susceptibility to insulin-dependent diabetes mellitus in Japanese.
Tissue antigens 1991;38(3):107-10.
1991: H Asakawa; Toshiaki Hanafusa; Y Oda; H Katsura; Jun-ichiro Miyagawa; K Mashita; Norio Kono; S Tarui
Human recombinant interleukin 1 inhibits TSH-stimulated morphological changes in thyroid follicles cultured as semi-organs.
Acta endocrinologica 1991;125(1):80-5.
1991: M Mori-Tanaka; K Tajima; Jun-ichiro Miyagawa; Y Oda; I Matsui; K Kitajima; Toshiaki Hanafusa; S Tarui; K Mashita
Inhibitory effects of ionophore A23187 on the release of thyroid hormone and colloid reabsorption in mouse thyroid glands.
Acta endocrinologica 1991;124(4):463-9.
1991: H Asakawa; Toshiaki Hanafusa; H Katsura; Jun-ichiro Miyagawa; A Otsuka; C Nakagawa; N Itoh; Norio Kono; S Tarui
Interferon-gamma inhibits thyroid-stimulating hormone-induced morphological changes and induces the expression of major histocompatibility complex class II antigen in thyroid follicles in suspension culture.
Endocrinology 1991;128(3):1409-13.
1990: Jun-ichiro Miyagawa; K Yamamoto; Toshiaki Hanafusa; N Itoh; C Nakagawa; A Otsuka; H Katsura; Kazuya Yamagata; A Miyazaki; Norio Kono
Preventive effect of a new immunosuppressant FK-506 on insulitis and diabetes in non-obese diabetic mice.
Diabetologia 1990;33(8):503-5.
1990: H Asakawa; Jun-ichiro Miyagawa; Toshiaki Hanafusa; H Katsura; A Miyazaki; A Otsuka; C Nakagawa; Kazuya Yamagata; K Tajima; K Mashita
Interferon-gamma reduces actin filaments and inhibits thyroid-stimulating hormone-induced formation of microvilli and pseudopods in mouse monolayer thyrocytes.
Endocrinology 1990;127(1):325-9.
1990: Toshiaki Hanafusa; A Miyazaki; Jun-ichiro Miyagawa; S Tamura; M Inada; K Yamada; Y Shinji; H Katsura; Kazuya Yamagata; N Itoh
Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients.
Diabetologia 1990;33(2):105-11.
1990: M Tsugawa; H Asakawa; Jun-ichiro Miyagawa; H Katsura; R Komatsu; S Iida; H Fujii; M Gomi; K Moriwaki; S Tarui
Rounding of cultured human carcinoid tumor cells by forskolin.
Anticancer research 1990;10(1):63-6.
1989: A Miyazaki; Toshiaki Hanafusa; N Itoh; Jun-ichiro Miyagawa; Norio Kono; S Tarui; C Kiyotaki; K Yoshizaki
Demonstration of interleukin-1 beta on perifollicular endothelial cells in the thyroid glands of patients with Graves' disease.
The Journal of clinical endocrinology and metabolism 1989;69(4):738-44.
1989: Kazuya Yamagata; Hiromu Nakajima; Toshiaki Hanafusa; Toshihide Noguchi; A Miyazaki; Jun-ichiro Miyagawa; M Sada; H Amemiya; T Tanaka; Norio Kono
Aspartic acid at position 57 of DQ beta chain does not protect against type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetologia 1989;32(10):762-4.
1988: M Mori; K Tajima; Jun-ichiro Miyagawa; M Shimizu; K Mashita; S Sugihara; Toshiyuki Hamaoka; Hiromi Fujiwara; S Tarui
Release of 3,5,3'-triiodothyronine, thyroxine and thyroglobulin from TSH-stimulated mouse thyroids in the perifusion system.
Experientia 1988;44(9):766-8.
1988: N Watanabe; T Matsuyama; Mitsuyoshi Namba; Jun-ichiro Miyagawa; H Itoh; R Komatsu; Norio Kono; S Tarui
Trophic effect of glucagon-(1-21)-peptide on the isolated rat ileal mucosal cells.
Biochemical and biophysical research communications 1988;152(3):1038-44.
1988: K Tajima; Jun-ichiro Miyagawa; M Mori; K Mashita; S Tarui
Ionophore A23187 inhibits the release of thyrotropin-stimulated 3, 5, 3'-triiodothyronine from perifused rat thyroid glands.
Journal of endocrinological investigation 1988;11(3):165-9.
1988: Toshiaki Hanafusa; S Sugihara; H Fujino-Kurihara; Jun-ichiro Miyagawa; A Miyazaki; T Yoshioka; K Yamada; Hiromu Nakajima; H Asakawa; Norio Kono
Induction of insulitis by adoptive transfer with L3T4+Lyt2- T-lymphocytes in T-lymphocyte-depleted NOD mice.
Diabetes 1988;37(2):204-8.
1987: M Tsugawa; K Moriwaki; Jun-ichiro Miyagawa; M Gomi; H Fujii; S Iida; S Tarui
Induction of differentiation of human phaeochromocytoma cells in culture by epidermal growth factor and insulin.
Anticancer research 1987;7(6):1161-3.
1987: Toshiaki Hanafusa; H Fujino-Kurihara; A Miyazaki; K Yamada; Hiromu Nakajima; Jun-ichiro Miyagawa; Norio Kono; S Tarui
Expression of class II major histocompatibility complex antigens on pancreatic B cells in the NOD mouse.
Diabetologia 1987;30(2):104-8.
1986: K Yamada; Toshiaki Hanafusa; H Fujino-Kurihara; A Miyazaki; Hiromu Nakajima; Jun-ichiro Miyagawa; Norio Kono; K Nonaka; S Tarui
Demonstration of islet cell surface antibodies in sera of New Zealand black mice and inhibitory effect on insulin release.
Diabetes 1986;35(11):1262-7.