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Michiko Miyaki

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Michiko Miyaki; Tatsuro Yamaguchi; Takeru Iijima; Keiichi Takahashi; Hiroshi Matsumoto; Takeo Mori
Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors.
Michiko Miyaki; Tatsuro Yamaguchi; Takeru Iijima; Keiichi Takahashi; Hiroshi Matsumoto; Michiya Yasutome; Nobuaki Funata; Takeo Mori
Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype.
Michiko Miyaki; Takeru Iijima; Tatsuro Yamaguchi; Keiichi Takahashi; Hiroshi Matsumoto; Michiya Yasutome; Nobuaki Funata; Takeo Mori
Mutations of the PIK3CA gene in hereditary colorectal cancers.

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All Publications

2009: Michiko Miyaki; Tatsuro Yamaguchi; Takeru Iijima; Keiichi Takahashi; Hiroshi Matsumoto; Takeo Mori
Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors.
Oncology 2009;76(6):430-4.
2008: Michiko Miyaki; Tatsuro Yamaguchi; Takeru Iijima; Keiichi Takahashi; Hiroshi Matsumoto; Michiya Yasutome; Nobuaki Funata; Takeo Mori
Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype.
International journal of cancer. Journal international du cancer 2008;122(11):2491-7.
2007: Michiko Miyaki; Takeru Iijima; Tatsuro Yamaguchi; Keiichi Takahashi; Hiroshi Matsumoto; Michiya Yasutome; Nobuaki Funata; Takeo Mori
Mutations of the PIK3CA gene in hereditary colorectal cancers.
International journal of cancer. Journal international du cancer 2007;121(7):1627-30.
2006: Tatsuro Yamaguchi; Takeru Iijima; Takeo Mori; Keiichi Takahashi; Hiroshi Matsumoto; Hidenori Miyamoto; Tsunekazu Hishima; Michiko Miyaki
Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer.
Diseases of the colon and rectum 2006;49(3):399-406.
2006: Michiko Miyaki; Tatsuro Yamaguchi; Takeru Iijima; Nobuaki Funata; Takeo Mori
Difference in the role of loss of heterozygosity at 10p15 (KLF6 locus) in colorectal carcinogenesis between sporadic and familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer patients.
Oncology 2006;71(1-2):131-5.
2005: Michiko Miyaki; Takeru Iijima; Tatsuro Yamaguchi; Tsunekazu Hishima; Kazuo Tamura; Joji Utsunomiya; Takeo Mori
Germline mutations of the MYH gene in Japanese patients with multiple colorectal adenomas.
Mutation research 2005;578(1-2):430-3.
2004: Joji Utsunomiya; Takeo Iwama; Michiko Miyaki; Kazuo Tamura; Masami Arai
A historical perspective on familial cancer: results and vision of the Polyposis Center Project.
International journal of clinical oncology 2004;9(4):215-31.
2004: Akira Tsunoda; Takeru Iijima; Yuko Tsunoda; Kentaroh Nakao; Michiko Miyaki; Mitsuo Kusano
Association of K-ras mutations with liver metastases from colorectal carcinoma.
Anticancer research 2004;24(4):2471-6.
2004: Michiko Miyaki; Takeru Iijima; Tatsuro Yamaguchi; Shuya Shirahama; Taichi Ito; Masamichi Yasuno; Takeo Mori
Novel germline hMSH2 genomic deletion and somatic hMSH2 mutations in a hereditary nonpolyposis colorectal cancer family.
Mutation research 2004;548(1-2):19-25.
2004: Chikashi Nakanishi; Tatsuro Yamaguchi; Takeru Iijima; Shigetoyo Saji; Masakazu Toi; Takeo Mori; Michiko Miyaki
Germline mutation of the LKB1/STK11 gene with loss of the normal allele in an aggressive breast cancer of Peutz-Jeghers syndrome.
Oncology 2004;67(5-6):476-9.
2004: Naoki Koshiishi; Ja-Mun Chong; Tomoki Fukasawa; Rie Ikeno; Yukiko Hayashi; Nobuaki Funata; Hideo Nagai; Michiko Miyaki; Yoshiro Matsumoto; Masashi Fukayama
p300 gene alterations in intestinal and diffuse types of gastric carcinoma.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2004;7(2):85-90.
2003: Michiko Miyaki; Takeru Iijima; M Ohue; Y Kita; Tsunekazu Hishima; Toshio Kuroki; Takeo Iwama; Takeo Mori
A novel case with germline p53 gene mutation having concurrent multiple primary colon tumours.
Gut 2003;52(2):304-6.
2002: Michiko Miyaki; Takeru Iijima; Masamichi Yasuno; Yumi Kita; Tsunekazu Hishima; Toshio Kuroki; Takeo Mori
High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas.
Oncogene 2002;21(43):6689-93.
2002: Michiko Miyaki
[Microsatellite instability in hereditary gastrointestinal polyposis].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2002;99(9):1057-62.
2002: Michiko Miyaki; Takeru Iijima; Reiko Ishii; Yumi Kita; Morio Koike; Toshio Kuroki; Takeo Mori
Increased frequency of p53 mutation in sporadic colorectal cancer from cigarette smokers.
Japanese journal of clinical oncology 2002;32(6):196-201.
2001: Michiko Miyaki; Takeru Iijima; K Shiba; T Aki; Yumi Kita; Masamichi Yasuno; Takeo Mori; Toshio Kuroki; Takeo Iwama
Alterations of repeated sequences in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome.
Oncogene 2001;20(37):5215-8.
2000: Michiko Miyaki; Takeru Iijima; R Ishii; Tsunekazu Hishima; Takeo Mori; K Yoshinaga; H Takami; T Kuroki; T Iwama
Molecular evidence for multicentric development of thyroid carcinomas in patients with familial adenomatous polyposis.
The American journal of pathology 2000;157(6):1825-7.
2000: Michiko Miyaki; Takeru Iijima; K Hosono; R Ishii; Masamichi Yasuno; Takeo Mori; M Toi; Tsunekazu Hishima; N Shitara; Kazuo Tamura; Joji Utsunomiya; N Kobayashi; Toshio Kuroki; Takeo Iwama
Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome.
Cancer research 2000;60(22):6311-3.
2000: K Kurihara; S Shimizu; J Chong; Tsunekazu Hishima; Nobuaki Funata; H Kashiwagi; H Nagai; Michiko Miyaki; Masashi Fukayama
Nuclear localization of immunoreactive beta-catenin is specific to familial adenomatous polyposis in papillary thyroid carcinoma.
Japanese journal of cancer research : Gann 2000;91(11):1100-2.
2000: Michiko Miyaki
[Peutz-Jeghers syndrome].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(7):1400-4.
2000: Michiko Miyaki; C Sato; K Sakai; M Konishi; K Tanaka; M Muraoka; R Kikuchi-Yanoshita; Y Nadaoka; H Kanda; T Kitagawa
Malignant transformation and EGFR activation of immortalized mouse liver epithelial cells caused by HBV enhancer-X from a human hepatocellular carcinoma.
International journal of cancer. Journal international du cancer 2000;85(4):518-22.
2000: M Enomoto; M Konishi; Takeo Iwama; Joji Utsunomiya; Kenichi Sugihara; Michiko Miyaki
The relationship between frequencies of extracolonic manifestations and the position of APC germline mutation in patients with familial adenomatous polyposis.
Japanese journal of clinical oncology 2000;30(2):82-8.
1999: Michiko Miyaki; Takeru Iijima; J Kimura; Masamichi Yasuno; Takeo Mori; Y Hayashi; Morio Koike; N Shitara; Takeo Iwama; Toshio Kuroki
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
Cancer research 1999;59(18):4506-9.
1999: Michiko Miyaki; Takeru Iijima; M Konishi; K Sakai; A Ishii; Masamichi Yasuno; Tsunekazu Hishima; Morio Koike; N Shitara; Takeo Iwama; Joji Utsunomiya; Toshio Kuroki; Takeo Mori
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis.
Oncogene 1999;18(20):3098-103.
1998: K Otori; M Konishi; K Sugiyama; T Hasebe; T Shimoda; R Kikuchi-Yanoshita; K Mukai; S Fukushima; Michiko Miyaki; Hiroyasu Esumi
Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue.
Cancer 1998;83(5):896-900.
1997: Michiko Miyaki; J Nishio; M Konishi; R Kikuchi-Yanoshita; K Tanaka; M Muraoka; M Nagato; Ja-Mun Chong; Morio Koike; T Terada; Yutaka Kawahara; A Fukutome; Junji Tomiyama; Yoshimichi Chuganji; Masaru Momoi; Joji Utsunomiya
Drastic genetic instability of tumors and normal tissues in Turcot syndrome.
Oncogene 1997;15(23):2877-81.
1997: Ja-Mun Chong; Masashi Fukayama; Y Hayashi; Tsunekazu Hishima; Nobuaki Funata; M Koike; S Matsuya; M Konishi; Michiko Miyaki
Microsatellite instability and loss of heterozygosity in gastric lymphoma.
Laboratory investigation; a journal of technical methods and pathology 1997;77(6):639-45.
1997: Michiko Miyaki; M Konishi; K Tanaka; R Kikuchi-Yanoshita; M Muraoka; Masamichi Yasuno; T Igari; Morio Koike; M Chiba; Takeo Mori
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
Nature genetics 1997;17(3):271-2.
1997: Ja-Mun Chong; Masashi Fukayama; Y Hayashi; Nobuaki Funata; T Takizawa; Morio Koike; M Muraoka; R Kikuchi-Yanoshita; Michiko Miyaki; S Mizuno
Expression of CD44 variants in gastric carcinoma with or without Epstein-Barr virus.
International journal of cancer. Journal international du cancer 1997;74(4):450-4.
1996: M Konishi; R Kikuchi-Yanoshita; K Tanaka; M Muraoka; A Onda; Y Okumura; N Kishi; Takeo Iwama; T Mori; M Koike; K Ushio; M Chiba; S Nomizu; F Konishi; J Utsunomiya; Michiko Miyaki
Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer.
Gastroenterology 1996;111(2):307-17.
1996: M Muraoka; M Konishi; R Kikuchi-Yanoshita; K Tanaka; N Shitara; J M Chong; Takeo Iwama; Michiko Miyaki
p300 gene alterations in colorectal and gastric carcinomas.
Oncogene 1996;12(7):1565-9.
1996: K Tanaka; R Kikuchi-Yanoshita; M Muraoka; M Konishi; M Oshimura; Michiko Miyaki
Suppression of tumorigenicity and invasiveness of colon carcinoma cells by introduction of normal chromosome 8p12-pter.
Oncogene 1996;12(2):405-10.
1995: Michiko Miyaki; K Tanaka; R Kikuchi-Yanoshita; M Muraoka; M Konishi; M Takeichi
Increased cell-substratum adhesion, and decreased gelatinase secretion and cell growth, induced by E-cadherin transfection of human colon carcinoma cells.
Oncogene 1995;11(12):2547-52.
1995: R Kikuchi-Yanoshita; K Tanaka; M Muraoka; M Konishi; I Kawashima; S Takamoto; H Hirai; Michiko Miyaki
Malignant transformation of rat embryo fibroblasts by cotransfection with eleven human mutant p53 cDNAs and activated H-ras gene.
Oncogene 1995;11(7):1339-45.
1995: Michiko Miyaki; M Konishi; M Muraoka; R Kikuchi-Yanoshita; K Tanaka; Takeo Iwama; T Mori; M Koike; K Ushio; M Chiba
Germ line mutations of hMSH2 and hMLH1 genes in Japanese families with hereditary nonpolyposis colorectal cancer (HNPCC): usefulness of DNA analysis for screening and diagnosis of HNPCC patients.
Journal of molecular medicine (Berlin, Germany) 1995;73(10):515-20.
1995: M Toyooka; M Konishi; R Kikuchi-Yanoshita; Takeo Iwama; Michiko Miyaki
Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.
Cancer research 1995;55(14):3165-70.
1995: Michiko Miyaki; K Tanaka; R Kikuchi-Yanoshita; M Muraoka; M Konishi
Familial polyposis: recent advances.
Critical reviews in oncology/hematology 1995;19(1):1-31.
1994: Ja-Mun Chong; Masashi Fukayama; Y Hayashi; T Takizawa; M Koike; M Konishi; R Kikuchi-Yanoshita; Michiko Miyaki
Microsatellite instability in the progression of gastric carcinoma.
Cancer research 1994;54(17):4595-7.
1994: Masashi Fukayama; Y Hayashi; Y Iwasaki; Ja-Mun Chong; T Ooba; T Takizawa; M Koike; S Mizutani; Michiko Miyaki; K Hirai
Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach.
Laboratory investigation; a journal of technical methods and pathology 1994;71(1):73-81.
1994: Michiko Miyaki; M Konishi; R Kikuchi-Yanoshita; M Enomoto; T Igari; K Tanaka; M Muraoka; H Takahashi; Y Amada; Masashi Fukayama
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
Cancer research 1994;54(11):3011-20.
1994: H Iino; Masashi Fukayama; Y Maeda; M Koike; T Mori; T Takahashi; R Kikuchi-Yanoshita; Michiko Miyaki; S Mizuno; S Watanabe
Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential.
Cancer 1994;73(5):1324-31.
1993: Michiko Miyaki; M Konishi; R Kikuchi-Yanoshita; M Enomoto; K Tanaka; H Takahashi; M Muraoka; T Mori; F Konishi; Takeo Iwama
Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis.
Cancer research 1993;53(21):5079-82.
1993: K Tanaka; R Yanoshita; M Konishi; M Oshimura; Y Maeda; T Mori; Michiko Miyaki
Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region.
Oncogene 1993;8(8):2253-8.
1992: R Kikuchi-Yanoshita; M Konishi; H Fukunari; K Tanaka; Michiko Miyaki
Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients.
Cancer research 1992;52(13):3801-3.
1992: M Seki; K Tanaka; R Kikuchi-Yanoshita; M Konishi; H Fukunari; Takeo Iwama; Michiko Miyaki
Loss of normal allele of the APC gene in an adrenocortical carcinoma from a patient with familial adenomatous polyposis.
Human genetics 1992;89(3):298-300.
1991: M A Yoshida; T Ikeuchi; Takeo Iwama; Michiko Miyaki; T Mori; Y Ushijima; A Hara; M Miyakita; A Tonomura
Chromosome changes in desmoid tumors developed in patients with familial adenomatous polyposis.
Japanese journal of cancer research : Gann 1991;82(8):916-21.
1991: K Tanaka; M Oshimura; R Kikuchi; M Seki; T Hayashi; Michiko Miyaki
Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18.
Nature 1991;349(6307):340-2.
1990: Michiko Miyaki; M Seki; M Okamoto; A Yamanaka; Y Maeda; K Tanaka; R Kikuchi; Takeo Iwama; T Ikeuchi; A Tonomura
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Cancer research 1990;50(22):7166-73.
1989: K Tanaka; C Sato; Y Maeda; M Koike; M Matsutani; K Yamada; Michiko Miyaki
Establishment of a human malignant meningioma cell line with amplified c-myc oncogene.
Cancer 1989;64(11):2243-9.
1989: M Sasaki; M Okamoto; C Sato; K Sugio; J Soejima; Takeo Iwama; T Ikeuchi; A Tonomura; Michiko Miyaki; Takehiko Sasazuki
Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma.
Cancer research 1989;49(16):4402-6.
1988: Michiko Miyaki; K Tanaka; C Sato; N Akamatsu; T Mori; N Tsuchida
Increased formation of unintegrated viral DNA in skin fibroblasts from patients with familial polyposis coli shortly after infection with Kirsten murine sarcoma virus.
International journal of cancer. Journal international du cancer 1988;42(5):739-43.
1988: Michiko Miyaki; N Akamatsu; C Sato; J Utsunomiya
Chemical and viral transformation of cultured skin fibroblasts from patients with familial polyposis coli.
Mutation research 1988;199(2):399-414.
1988: C Sato; Michiko Miyaki; S Oikawa; H Nakazato; G Kosaki
Differential expression of carcinoembryonic antigen and nonspecific crossreacting antigen genes in human colon adenocarcinomas and normal colon mucosa.
Japanese journal of cancer research : Gann 1988;79(4):433-7.
1988: M Okamoto; M Sasaki; K Sugio; C Sato; Takeo Iwama; T Ikeuchi; A Tonomura; Takehiko Sasazuki; Michiko Miyaki
Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli.
Nature 1988;331(6153):273-7.
1986: Y Yuasa; Michiei Oto; C Sato; Michiko Miyaki; Takeo Iwama; A Tonomura; M Namba
Colon carcinoma K-ras 2 oncogene of a familial polyposis coli patient.
Japanese journal of cancer research : Gann 1986;77(9):901-7.
1985: Michiko Miyaki; C Sato; T Matsui; M Koike; T Mori; G Kosaki; S Takai; A Tonomura; N Tsuchida
Amplification and enhanced expression of cellular oncogene c-Ki-ras-2 in a human epidermoid carcinoma of the lung.
Japanese journal of cancer research : Gann 1985;76(4):260-5.
1982: Michiko Miyaki; N Akamatsu; T Ono; A Tonomura; J Utsunomiya
Morphologic transformation and chromosomal changes induced by chemical carcinogens in skin fibroblasts from patients with familial adenomatosis coli.
Journal of the National Cancer Institute 1982;68(4):563-71.
1980: Michiko Miyaki; N Akamatsu; M Rokutanda; T Ono; H Yoshikura; M Sasaki; A Tonomura; J Utsunomiya
Increased sensitivity of fibroblasts of skin from patients with adenomatosis coli and Peutz-Jegher's syndrome to transformation by murine sarcoma virus.
Gann = Gan 1980;71(6):797-803.
1980: Michiko Miyaki; N Akamatsu; U Hirono; T Ono; A Tonomura; J Utsunomiya
Transformation of fibroblasts from a patient with adenomatosis coli by treatment with a chemical carcinogen.
Gann = Gan 1980;71(5):741-2.