Mizuo Miyazaki

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Takai Shinji; Jin Denan; Ikeda Hironobu; Sakonjo Hiroshi; Miyazaki Mizuo
Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats.
Takai Shinji; Jin Denan; Kawashima Hiroshi; Kimura Maki; Shiraishi-Tateishi Akiko; Tanaka Takao; Kakutani Saki; Tanaka Kazuhiko; Kiso Yoshinobu; Miyazaki Mizuo
Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.
Takai Shinji; Jin Denan; Ohzu Mariko; Tanaka Kazuhiko; Miyazaki Mizuo
Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes.

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All Publications

2009: Takai Shinji; Jin Denan; Ikeda Hironobu; Sakonjo Hiroshi; Miyazaki Mizuo
Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(10):853-60.
2009: Takai Shinji; Jin Denan; Kawashima Hiroshi; Kimura Maki; Shiraishi-Tateishi Akiko; Tanaka Takao; Kakutani Saki; Tanaka Kazuhiko; Kiso Yoshinobu; Miyazaki Mizuo
Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.
Journal of atherosclerosis and thrombosis 2009;16(4):480-9.
2009: Takai Shinji; Jin Denan; Ohzu Mariko; Tanaka Kazuhiko; Miyazaki Mizuo
Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes.
Journal of pharmacological sciences 2009;110(4):459-65.
2009: Inoue Nao; Muramatsu Michiko; Jin Denan; Takai Shinji; Hayashi Tetsuya; Katayama Hiroshi; Kitaura Yasushi; Tamai Hiroshi; Miyazaki Mizuo
Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice.
Journal of atherosclerosis and thrombosis 2009;16(3):164-71.
2009: Inoue Nao; Muramatsu Michiko; Jin Denan; Takai Shinji; Hayashi Tetsuya; Katayama Hiroshi; Kitaura Yasushi; Tamai Hiroshi; Miyazaki Mizuo
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice.
Atherosclerosis 2009;204(2):359-64.
2009: Amano Nobuyuki; Takai Shinji; Jin Denan; Ueda Koichi; Miyazaki Mizuo
Possible roles of mast cell-derived chymase for skin rejuvenation.
Lasers in medical science 2009;24(2):223-9.
2009: Jin Denan; Takai Shinji; Sugiyama Tetsuya; Hayashi Tetsuya; Fukumoto Masanori; Oku Hidehiro; Kitaura Yasushi; Ikeda Tsunehiko; Miyazaki Mizuo
Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis.
Journal of pharmacological sciences 2009;109(2):275-84.
2008: Fukumoto Masanori; Takai Shinji; Ishizaki Eisuke; Sugiyama Tetsuya; Oku Hidehiro; Jin Denan; Sakaguchi Masato; Sakonjo Hiroshi; Ikeda Tsunehiko; Miyazaki Mizuo
Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model.
Current eye research 2008;33(10):885-91.
2008: Yamamoto Daisuke; Takai Shinji; Miyazaki Mizuo
Inhibitory profiles of captopril on matrix metalloproteinase-9 activity.
European journal of pharmacology 2008;588(2-3):277-9.
2008: Komeda Koji; Jin Denan; Takai Shinji; Hayashi Michihiro; Takeshita Atsushi; Shibayama Yuro; Tanigawa Nobuhiko; Miyazaki Mizuo
Significance of chymase-dependent angiotensin II formation in the progression of human liver fibrosis.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(5):501-10.
2008: Ishida Kumi; Takai Shinji; Murano Mitsuyuki; Nishikawa Takashi; Inoue Takuya; Murano Naoko; Inoue Nao; Jin Denan; Umegaki Eiji; Higuchi Kazuhide; Miyazaki Mizuo
Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis.
The Journal of pharmacology and experimental therapeutics 2008;324(2):422-6.
2008: Furubayashi Keiichi; Takai Shinji; Jin Denan; Miyazaki Mizuo; Katsumata Takahiro; Inagaki Sachiko; Kimura Maki; Tanaka Kazuhiko; Nishimoto Masayoshi; Fukumoto Hitoshi
Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm.
Clinica chimica acta; international journal of clinical chemistry 2008;388(1-2):214-6.
2007: Takai Shinji; Jin Denan; Kimura Maki; Kirimura Kazuyoshi; Sakonjo Hiroshi; Tanaka Kazuhiko; Miyazaki Mizuo
Inhibition of vascular angiotensin-converting enzyme by telmisartan via the peroxisome proliferator-activated receptor gamma agonistic property in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(12):1231-7.
2007: Takai Shinji; Jin Denan; Inagaki Sachiko; Yamamoto Daisuke; Tanaka Kazuhiko; Miyazaki Mizuo
Significance of matrix metalloproteinase-9 in cardiac dysfunction during the very acute phase after myocardial infarction in hamsters.
European journal of pharmacology 2007;572(1):57-60.
2007: Jin Denan; Ueda Haruhiko; Takai Shinji; Muramatsu Michiko; Furubayashi Keiichi; Ibaraki Toshihiko; Kishi Kanta; Katsuoka Yoji; Miyazaki Mizuo
Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations.
Life sciences 2007;81(16):1291-300.
2007: Takai Shinji; Yamamoto Daisuke; Jin Denan; Inagaki Sachiko; Yoshikawa Katsuhiro; Tanaka Kazuhiko; Miyazaki Mizuo
Inhibition of matrix metalloproteinase-9 activity by lisinopril after myocardial infarction in hamsters.
European journal of pharmacology 2007;568(1-3):231-3.
2007: Furubayashi Keiichi; Takai Shinji; Jin Denan; Muramatsu Michiko; Ibaraki Toshihiko; Nishimoto Masayoshi; Fukumoto Hitoshi; Katsumata Takahiro; Miyazaki Mizuo
The significance of chymase in the progression of abdominal aortic aneurysms in dogs.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(4):349-57.
2007: Kishi Kanta; Muramatsu Michiko; Jin Denan; Furubayashi Keiichi; Takai Shinji; Tamai Hiroshi; Miyazaki Mizuo
The effects of chymase on matrix metalloproteinase-2 activation in neointimal hyperplasia after balloon injury in dogs.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(1):77-83.
2006: Miyazaki Mizuo; Takai Shinji; Jin Denan; Muramatsu Michiko
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.
Pharmacology & therapeutics 2006;112(3):668-76.
2006: Takai Shinji; Miyazaki Mizuo
[Anti-atherosclerotic effect]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():518-23.
2006: Takai Shinji; Miyazaki Mizuo
[Tumor suppressive effect]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():512-7.
2006: Miyazaki Mizuo
[Tissue angiotensin II generating system]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():57-62.
2006: Kishi Kanta; Jin Denan; Takai Shinji; Muramatsu Michiko; Katayama Hiroshi; Tamai Hiroshi; Miyazaki Mizuo
Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.
Pediatric research 2006;60(1):77-82.
2006: Takai Shinji; Miyazaki Mizuo
Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2006;6(6):363-6.
2006: Miyazaki Mizuo; Takai Shinji
Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase.
Journal of pharmacological sciences 2006;100(5):391-7.
2005: Takai Shinji; Jin Denan; Muramatsu Michiko; Kirimura Kazuyoshi; Sakonjo Hiroshi; Miyazaki Mizuo
Eplerenone inhibits atherosclerosis in nonhuman primates.
Hypertension 2005;46(5):1135-9.
2005: Takai Shinji; Jin Denan; Sakaguchi Masato; Muramatsu Michiko; Miyazaki Mizuo
The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet.
Journal of hypertension 2005;23(10):1879-86.
2005: Ibaraki Toshihiko; Muramatsu Michiko; Takai Shinji; Jin Denan; Maruyama Hiroshi; Orino Tatsuhiko; Katsumata Takahiro; Miyazaki Mizuo
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2005;28(4):617-21.
2005: Takai Shinji; Kirimura Kazuyoshi; Jin Denan; Muramatsu Michiko; Yoshikawa Katsuhiro; Mino Yoshiki; Miyazaki Mizuo
Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(7):593-600.
2005: Kirimura Kazuyoshi; Takai Shinji; Jin Denan; Muramatsu Michiko; Kishi Kanta; Yoshikawa Katsuhiro; Nakabayashi Mika; Mino Yoshiki; Miyazaki Mizuo
Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(5):457-64.
2005: Jin Denan; Ueda Haruhiko; Takai Shinji; Okamoto Yukiko; Muramatsu Michiko; Sakaguchi Masato; Shibahara Nobuhisa; Katsuoka Yoji; Miyazaki Mizuo
Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs.
Journal of the American Society of Nephrology : JASN 2005;16(4):1024-34.
2004: Takai Shinji; Jin Denan; Muramatsu Michiko; Okamoto Yukiko; Miyazaki Mizuo
Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis.
European journal of pharmacology 2004;501(1-3):1-8.
2004: Takai Shinji; Jin Denan; Muramatsu Michiko; Miyazaki Mizuo
Chymase as a novel target for the prevention of vascular diseases.
Trends in pharmacological sciences 2004;25(10):518-22.
2004: Jin Denan; Takai Shinji; Okamoto Yukiko; Muramatsu Michiko; Miyazaki Mizuo
Chymase-derived angiotensin II and arrhythmias after myocardial infarction.
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2004;124(2):77-82.
2004: Takai Shinji; Jin Denan; Sakaguchi Masato; Muramatsu Michiko; Ishii Kenji; Kirimura Kazuyoshi; Sakonjo Hiroshi; Miyazaki Mizuo
Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(7):517-22.
2004: Maruichi Midori; Takai Shinji; Sugiyama Tetsuya; Ueki Mari; Oku Hidehiro; Sakaguchi Masato; Okamoto Yukiko; Muramatsu Michiko; Ikeda Tsunehiko; Miyazaki Mizuo
Role of chymase on growth of cultured canine Tenon's capsule fibroblasts and scarring in a canine conjunctival flap model.
Experimental eye research 2004;79(1):111-8.
2004: Sakaguchi Masato; Takai Shinji; Jin Denan; Okamoto Yukiko; Muramatsu Michiko; Kim Shokei; Miyazaki Mizuo
A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters.
European journal of pharmacology 2004;493(1-3):173-6.
2004: Tsunemi Koutaro; Takai Shinji; Nishimoto Masayoshi; Jin Denan; Sakaguchi Masato; Muramatsu Michiko; Yuda Atsushi; Sasaki Shinjiro; Miyazaki Mizuo
A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters.
The Journal of pharmacology and experimental therapeutics 2004;309(3):879-83.
2004: Jin Denan; Takai Shinji; Sakaguchi Masato; Okamoto Yukiko; Muramatsu Michiko; Miyazaki Mizuo
An antiarrhythmic effect of a chymase inhibitor after myocardial infarction.
The Journal of pharmacology and experimental therapeutics 2004;309(2):490-7.
2004: Takai Shinji; Jin Denan; Sakaguchi Masato; Miyazaki Mizuo
A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins.
Journal of pharmacological sciences 2004;94(4):443-8.
2004: Takai Shinji; Jin Denan; Sakaguchi Masato; Miyazaki Mizuo
Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(3):213-9.
2004: Okamoto Yukiko; Takai Shinji; Miyazaki Mizuo
Significance of chymase inhibition for prevention of adhesion formation.
European journal of pharmacology 2004;484(2-3):357-9.
2004: Miyazaki Mizuo
[Angiotensin II in organ organopathy]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(1):21-7.
2004: Okamoto Yukiko; Takai Shinji; Miyazaki Mizuo
Effect of chymase-dependent transforming growth factor beta on peritoneal adhesion formation in a rat model.
Surgery today 2004;34(10):865-7.
2003: Jin Denan; Takai Shinji; Yamada Mayumi; Sakaguchi Masato; Kamoshita Keiichi; Ishida Koichi; Sukenaga Yoshikazu; Miyazaki Mizuo
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction.
Cardiovascular research 2003;60(2):413-20.
2003: Takai Shinji; Miyazaki Mizuo
A novel therapeutic strategy against vascular disorders with chymase inhibitor.
Current vascular pharmacology 2003;1(2):217-24.
2003: Takai Shinji; Jin Denan; Sakaguchi Masato; Katayama Satoru; Muramatsu Michiko; Sakaguchi Minoru; Matsumura Eiko; Kim Shokei; Miyazaki Mizuo
A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters.
The Journal of pharmacology and experimental therapeutics 2003;305(1):17-23.
2003: Muramatsu Michiko; Takai Shinji; Miyazaki Mizuo
[Detections of matrix metalloproteinases activities and localization by film in situ zymography (FIZ)]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;121(2):113-8.
2003: Takai Shinji; Kim Shokei; Sakonjo Hiroshi; Miyazaki Mizuo
Mechanisms of angiotensin II type 1 receptor blocker for anti-atherosclerotic effect in monkeys fed a high-cholesterol diet.
Journal of hypertension 2003;21(2):361-9.
2003: Takai Shinji; Sakonjo Hiroshi; Fukuda Kohzo; Jin Denan; Sakaguchi Masato; Kamoshita Keiichi; Ishida Koichi; Sukenaga Yoshikazu; Miyazaki Mizuo
A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[,4-dioxo-1-phenyl-7-(2-pyridyloxy)]2-heptyl]acetamide (NK3201), suppressed intimal hyperplasia after balloon injury.
The Journal of pharmacology and experimental therapeutics 2003;304(2):841-4.
2003: Takai Shinji; Miyazaki Mizuo
Application of a chymase inhibitor, NK3201, for prevention of vascular proliferation.
Cardiovascular drug reviews 2003;21(3):185-98.
2002: Takai Shinji; Miyazaki Mizuo
Effect of chymase inhibitor on vascular proliferation.
Japanese journal of pharmacology 2002;90(3):223-7.
2002: Sukenaga Yoshikazu; Kamoshita Keiichi; Takai Shinji; Miyazaki Mizuo
Development of the chymase inhibitor as an anti-tissue-remodeling drug: myocardial infarction and some other possibilities.
Japanese journal of pharmacology 2002;90(3):218-22.
2002: Tsunemi Koutaro; Takai Shinji; Nishimoto Masayoshi; Yuda Atsushi; Hasegawa Shigeto; Sawada Yoshihide; Fukumoto Hitoshi; Sasaki Shinjiro; Miyazaki Mizuo
Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):817-22.
2002: Okamoto Yukiko; Takai Shinji; Miyazaki Mizuo
Chymase inhibitor, BCEAB, suppressed peritoneal adhesion formation in hamster.
The Journal of surgical research 2002;107(2):219-22.
2002: Miyazaki Mizuo; Takai Shinji
[Involvement of angiotensin II in development of atherosclerosis]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(10):1904-10.
2002: Muramatsu Michiko; Yamada Mayumi; Takai Shinji; Miyazaki Mizuo
Suppression of basic fibroblast growth factor-induced angiogenesis by a specific chymase inhibitor, BCEAB, through the chymase-angiotensin-dependent pathway in hamster sponge granulomas.
British journal of pharmacology 2002;137(4):554-60.
2002: Okamoto Yukiko; Takai Shinji; Miyazaki Mizuo
Oral administration of a novel chymase inhibitor, NK3201, prevents peritoneal adhesion formation in hamsters.
Japanese journal of pharmacology 2002;90(1):94-6.
2002: Nishimoto Masayoshi; Takai Shinji; Fukumoto Hitoshi; Tsunemi Koutaro; Yuda Atsushi; Sawada Yoshihide; Yamada Mayumi; Jin Denan; Sakaguchi Masato; Nishimoto Yasuhisa; Sasaki Shinjiro; Miyazaki Mizuo
Increased local angiotensin II formation in aneurysmal aorta.
Life sciences 2002;71(18):2195-205.
2002: Tsunemi Koutaro; Takai Shinji; Nishimoto Masayoshi; Yuda Atsushi; Jin Denan; Sakaguchi Masato; Sawada Yoshihide; Asada Kunio; Kondo Keiichiro; Sasaki Shinjiro; Miyazaki Mizuo
Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins.
The Journal of thoracic and cardiovascular surgery 2002;124(3):621-5.
2002: Okamoto Ken; Takai Shinji; Sasaki Shinjiro; Miyazaki Mizuo
Trandolapril reduces infarction area after middle cerebral artery occlusion in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(4):583-8.
2002: Jin Denan; Takai Shinji; Yamada Mayumi; Sakaguchi Masato; Miyazaki Mizuo
Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction.
Life sciences 2002;71(4):437-46.
2002: Okamoto Yukiko; Takai Shinji; Yamada Mayumi; Miyazaki Mizuo
Chymase inhibitors may prevent postoperative adhesion formation.
Fertility and sterility 2002;77(5):1044-8.
2002: Miyazaki M; Takai S
Anti-atherosclerotic efficacy of olmesartan.
Journal of human hypertension 2002;16 Suppl 2():S7-12.
2002: Okumura Kenichi; Jin Denan; Takai Shinji; Miyazaki Mizuo
Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters.
Japanese journal of pharmacology 2002;88(2):183-8.
2002: Okamoto Yukiko; Takai Shinji; Miyazaki Mizuo
Chymase inhibitor suppresses adhesion formation in a hamster experimental model.
European journal of pharmacology 2002;435(2-3):265-7.
2001: Takai S; Sakonjo H; Miyazaki M
Beneficial effect of trandolapril on the lifespan of a severe hypertensive model.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(5):559-64.
2001: Nishimoto M; Takai S; Kim S; Jin D; Yuda A; Sakaguchi M; Yamada M; Sawada Y; Kondo K; Asada K; Iwao H; Sasaki S; Miyazaki M
Significance of chymase-dependent angiotensin II-forming pathway in the development of vascular proliferation.
Circulation 2001;104(11):1274-9.
2001: Takai S; Jin D; Nishimoto M; Yuda A; Sakaguchi M; Kamoshita K; Ishida K; Sukenaga Y; Sasaki S; Miyazaki M
Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein.
Life sciences 2001;69(15):1725-32.
2001: Jin D; Takai S; Yamada M; Sakaguchi M; Yao Y; Miyazaki M
Possible roles of cardiac chymase after myocardial infarction in hamster hearts.
Japanese journal of pharmacology 2001;86(2):203-14.
2001: Takai S; Jin D; Sakaguchi M; Kirimura K; Miyazaki M
An orally active chymase inhibitor, BCEAB, suppresses heart chymase activity in the hamster.
Japanese journal of pharmacology 2001;86(1):124-6.
2001: Miyazaki M; Takai S
Local angiotensin II-generating system in vascular tissues: the roles of chymase.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(3):189-93.
2001: Takai S; Jin D; Kirimura K; Fujimoto Y; Miyazaki M
12-Hydroxyeicosatetraenoic acid potentiates angiotensin II-induced pressor response in rats.
European journal of pharmacology 2001;418(1-2):R1-2.
2001: Nishimoto M; Takai S; Sawada Y; Yuda A; Kondo K; Yamada M; Jin D; Sakaguchi M; Asada K; Sasaki S; Miyazaki M
Chymase-dependent angiotensin II formation in the saphenous vein versus the internal thoracic artery.
The Journal of thoracic and cardiovascular surgery 2001;121(4):729-34.
2001: Yamada M; Ueda M; Naruko T; Tanabe S; Han Y S; Ikura Y; Ogami M; Takai S; Miyazaki M
Mast cell chymase expression and mast cell phenotypes in human rejected kidneys.
Kidney international 2001;59(4):1374-81.
2001: Takai S; Sakaguchi M; Jin D; Yamada M; Kirimura K; Miyazaki M
Different angiotensin II-forming pathways in human and rat vascular tissues.
Clinica chimica acta; international journal of clinical chemistry 2001;305(1-2):191-5.
2001: Takao K; Takai S; Ishihara T; Mita S; Miyazaki M
Isolation of chymase complexed with physiological inhibitor similar to secretory leukocyte protease inhibitor (SLPI) from hamster cheek pouch tissues.
Biochimica et biophysica acta 2001;1545(1-2):146-52.
2001: Tsunemi K; Nishimoto M; Takai S; Yuda A; Nishimoto Y; Hasegawa S; Asada K; Sawada Y; Kondo K; Fukumoto H; Miyazaki M; Sasaki S
[Role of angiotensin II-forming pathway in ruptured aortic aneurysms]
Nippon Geka Gakkai zasshi 2001;102(2):243.
2001: Takai S; Jin D; Nishimoto M; Sakaguchi M; Kirimura K; Yuda A; Miyazaki M
Cilostazol suppresses intimal formation in dog grafted veins with reduction of angiotensin II-forming enzymes.
European journal of pharmacology 2001;411(3):301-4.
2000: Jin D; Takai S; Yamada M; Sakaguchi M; Miyazaki M
The functional ratio of chymase and angiotensin converting enzyme in angiotensin I-induced vascular contraction in monkeys, dogs and rats.
Japanese journal of pharmacology 2000;84(4):449-54.
2000: Sakaguchi M; Takai S; Jin D; Yamada M; Miyazaki M
Characteristics of monkey tryptase purified from cheek pouch vascular tissues.
Japanese journal of pharmacology 2000;84(4):375-80.
2000: Yuda A; Takai S; Jin D; Sawada Y; Nishimoto M; Matsuyama N; Asada K; Kondo K; Sasaki S; Miyazaki M
Angiotensin II receptor antagonist, L-158,809, prevents intimal hyperplasia in dog grafted veins.
Life sciences 2000;68(1):41-8.
2000: Takai S; Sakaguchi M; Jin D; Miyazaki M
A new method for simultaneous measurements of mast cell proteases in human vascular tissue.
Clinical and experimental pharmacology & physiology 2000;27(9):700-4.
2000: Takai S; Sumi S; Aoike M; Sakaguchi M; Itoh Y; Jin D; Matsumura E; Miyazaki M
Characterization of recombinant human chymase expressed in Escherichia coli.
Japanese journal of pharmacology 2000;82(2):144-9.
2000: Takai S; Yuda A; Jin D; Nishimoto M; Sakagichi M; Sasaki S; Miyazaki M
Inhibition of chymase reduces vascular proliferation in dog grafted veins.
FEBS letters 2000;467(2-3):141-4.
2000: Miyazaki M
[Renin gene]
Nippon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():502-6.
1999: Takao K; Takai S; Ishihara T; Mita S; Miyazaki M
Inhibition of human chymase by suramin.
Japanese journal of pharmacology 1999;81(4):404-7.
1999: Takai S; Jin D; Miyazaki M
[Pathophysiological roles of chymase and effects of chymase inhibitor]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():41P-47P.
1999: Miyazaki M; Sakonjo H; Takai S
Anti-atherosclerotic effects of an angiotensin converting enzyme inhibitor and an angiotensin II antagonist in Cynomolgus monkeys fed a high-cholesterol diet.
British journal of pharmacology 1999;128(3):523-9.
1999: Takai S; Jin D; Sakaguchi M; Miyazaki M
Chymase-dependent angiotensin II formation in human vascular tissue.
Circulation 1999;100(6):654-8.
1999: Takai S; Jin D; Kirimura K; Ikeda J; Sakaguchi M; Baba K; Fujita T; Miyazaki M
Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II.
Japanese journal of pharmacology 1999;80(1):89-92.
1999: Takai S; Miyazaki M
[Role of angiotensin II-forming enzymes, angiotensin-converting enzyme and chymase]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(5):1078-83.
1999: Miyazaki M; Shiota N; Sakonjo H; Takai S
Angiotensin II type 1 receptor antagonist, TCV-116, prevents neointima formation in injured arteries in the dog.
Japanese journal of pharmacology 1999;79(4):455-60.
1999: Miyazaki M; Takai S
Antiatherosclerotic effect of alacepril, an angiotensin-converting enzyme inhibitor, in monkeys fed a high-cholesterol diet.
Hypertension research : official journal of the Japanese Society of Hypertension 1999;22(1):49-54.
1999: Takao K; Takai S; Shiota N; Song K; Nishimura K; Ishihara T; Miyazaki M
Lack of effect of carbohydrate depletion on some properties of human mast cell chymase.
Biochimica et biophysica acta 1999;1427(1):74-81.
1999: Shiota N; Okunishi H; Takai S; Mikoshiba I; Sakonjo H; Shibata N; Miyazaki M
Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery.
Circulation 1999;99(8):1084-90.
1999: Takai S; Jin D; Sakaguchi M; Kirimura K; Ikeda J; Baba K; Fujita T; Miyazaki M
Effects of a new 12-lipoxygenase inhibitor, daphnodorin A, on angiotensin II-induced vascular contraction in hamster.
Prostaglandins, leukotrienes, and essential fatty acids 1999;60(2):135-8.
1999: Song K; Kanehara H; Takai S; Shiota N; Wada T; Inada Y; Miyazaki M
Inhibition of the angiotensin II Type 1 receptor by TCV-116: quantitation by in vitro autoradiography.
Japanese journal of pharmacology 1999;79(2):131-9.
1999: Miyazaki M; Wada T; Shiota N; Takai S
Effect of an angiotensin II receptor antagonist, candesartan cilexetil, on canine intima hyperplasia after balloon injury.
Journal of human hypertension 1999;13 Suppl 1():S21-5; discussion S33-4.
1999: Takai S; Sakaguchi M; Jin D; Baba K; Miyazaki M
Effects of daphnodorin A, daphnodorin B and daphnodorin C on human chymase-dependent angiotensin II formation.
Life sciences 1999;64(21):1889-96.
1998: Jin D; Takai S; Shiota N; Miyazaki M
Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.
European journal of pharmacology 1998;361(2-3):199-205.
1998: Takai S; Shiota N; Jin D; Miyazaki M
Functional role of chymase in angiotensin II formation in human vascular tissue.
Journal of cardiovascular pharmacology 1998;32(5):826-33.
1998: Takai S; Shiota N; Jin D; Miyazaki M
Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea.
European journal of pharmacology 1998;358(3):229-33.
1998: Takai S; Jin D; Hara K; Takami H; Fujita T; Miyazaki M
12-Hydroxyeicosatetraenoic acid directly potentiates angiotensin II-induced vascular contraction.
European journal of pharmacology 1998;358(2):161-4.
1998: Kanehara H; Song K; Hirai K; Ueda H; Shiota N; Azuma H; Katsuoka Y; Miyazaki H; Miyazaki M
Involvement of angiotensin II receptor subtypes during testicular development in rats.
International journal of andrology 1998;21(4):186-95.
1998: Hirai K; Song K; Kanehara H; Shiota N; Ueda H; Kim S; Miyazaki H; Katsuoka Y; Miyazaki M
Pituitary-dependent expression of the testicular angiotensin II receptor and its subtypes in rats.
International journal of andrology 1998;21(4):177-85.
1998: Shiota N; Fukamizu A; Okunishi H; Takai S; Murakami K; Miyazaki M
Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts.
The Biochemical journal 1998;333 ( Pt 2)():417-24.
1998: Jin D; Takai S; Shiota N; Miyazaki M
Roles of vascular angiotensin converting enzyme and chymase in two-kidney, one clip hypertensive hamsters.
Journal of hypertension 1998;16(5):657-64.
1998: Song K; Shiota N; Takai S; Takashima H; Iwasaki H; Kim S; Miyazaki M
Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys.
Atherosclerosis 1998;138(1):171-82.
1997: Jin D; Song K; Oka Y; Takai S; Shiota N; Miyazaki M
Pharmacological profiles of a novel non-peptide angiotensin II type I receptor antagonist HR720 in vitro and in vivo.
Japanese journal of pharmacology 1997;75(3):259-66.
1997: Takai S; Shiota N; Sakaguchi M; Muraguchi H; Matsumura E; Miyazaki M
Characterization of chymase from human vascular tissues.
Clinica chimica acta; international journal of clinical chemistry 1997;265(1):13-20.
1997: Takai S; Shiota N; Kobayashi S; Matsumura E; Miyazaki M
Induction of chymase that forms angiotensin II in the monkey atherosclerotic aorta.
FEBS letters 1997;412(1):86-90.
1997: Shiota N; Fukamizu A; Takai S; Okunishi H; Murakami K; Miyazaki M
Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart.
Journal of hypertension 1997;15(4):431-40.
1997: Shiota N; Jin D; Takai S; Kawamura T; Koyama M; Nakamura N; Miyazaki M
Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension.
FEBS letters 1997;406(3):301-4.
1997: Shiota N; Saegusa Y; Nishimura K; Miyazaki M
Angiotensin II-generating system in dog and monkey ocular tissues.
Clinical and experimental pharmacology & physiology 1997;24(3-4):243-8.
1996: Takai S; Song K; Tanaka T; Okunishi H; Miyazaki M
Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice.
Life sciences 1996;59(21):PL331-6.
1996: Takai S; Shiota N; Yamamoto D; Okunishi H; Miyazaki M
Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch.
Life sciences 1996;58(7):591-7.
1995: Song K; Kurobe Y; Kanehara H; Wada T; Inada Y; Nishikawa K; Miyazaki M
Mapping of angiotensin II receptor subtypes in peripheral tissues of spontaneously hypertensive rats by in vitro autoradiography.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S17-9.
1995: Miyazaki M; Kawamoto T; Okunishi H
Vascular affinity of trandolapril.
American journal of hypertension 1995;8(10 Pt 2):63S-67S.
1994: Miyazaki M
Antihypertensive, antiatherosclerotic, and plasma lipid-lowering effects of monatepil, a novel calcium antagonist with alpha 1-adrenoceptor-blocking activity in experimental animals.
American journal of hypertension 1994;7(10 Pt 2):131S-40S.
1994: Song K; Miyazaki M; Okunishi H; Ishii K; Takai S; Shiota N; Kim S; Mendelsohn F A
Localization and quantitation of active renin in monkey kidney by radioinhibitor binding and in vitro autoradiography.
American journal of hypertension 1994;7(6):529-35.
1994: Saitoh H; Etoh Y; Murakami M; Kubota T; Miyazaki M
[Hypotensive action of human renin inhibitor KRI-1314 in the common marmoset]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1994;103(4):161-73.
1994: Miyazaki M; Hosoki K; Okunishi H; Ishii K; Ikeno A; Okazaki Y
Anti-atherosclerotic and plasma lipid lowering effects of the novel calcium blocker with alpha 1-adrenoceptor antagonistic activity, monatepil, in high cholesterol diet-fed Japanese Macaca fuscata monkeys.
Arzneimittel-Forschung 1994;44(3):288-97.
1994: Song K; Kurobe Y; Kanehara H; Okunishi H; Wada T; Inada Y; Nishikawa K; Miyazaki M
Quantitative localization of angiotensin II receptor subtypes in spontaneously hypertensive rats.
Blood pressure. Supplement 1994;5():21-6.
1993: Etoh Y; Miyazaki M; Saitoh H; Toda N
KRI-1314: an orally effective inhibitor of human renin.
Japanese journal of pharmacology 1993;63(1):109-19.
1993: Okunishi H; Song K; Oka Y; Kobayashi T; Kawamoto T; Ishihara H; Mori N; Miyazaki M
In vitro pharmacology of a novel non-peptide angiotensin II-receptor antagonist, E4177.
Japanese journal of pharmacology 1993;62(3):239-44.
1993: Okunishi H; Oka Y; Shiota N; Kawamoto T; Song K; Miyazaki M
Marked species-difference in the vascular angiotensin II-forming pathways: humans versus rodents.
Japanese journal of pharmacology 1993;62(2):207-10.
1993: Shiota N; Okunishi H; Fukamizu A; Sakonjo H; Kikumori M; Nishimura T; Nakagawa T; Murakami K; Miyazaki M
Activation of two angiotensin-generating systems in the balloon-injured artery.
FEBS letters 1993;323(3):239-42.
1992: Shiota N; Miyazaki M; Okunishi H
Increase of angiotensin converting enzyme gene expression in the hypertensive aorta.
Hypertension 1992;20(2):168-74.
1992: Song K; Shiota N; Okunishi H; Miyazaki M
Nephrectomy and a newly identified binding site for angiotensin II in the rat adrenal cortex.
Life sciences 1992;51(18):PL165-70.
1991: Morishita R; Higaki J; Okunishi H; Kawamoto T; Ishii K; Nakamura F; Katahira K; Nagano M; Mikami H; Miyazaki M
Effect of long-term treatment with an angiotensin-converting enzyme inhibitor on the renin-angiotensin system in spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 1991;18(10):685-90.
1991: Morishita R; Higaki J; Nagano M; Mikami H; Ogihara T; Tanaka T; Ishii K; Okunishi H; Miyazaki M
Consistent activation of prorenin mRNA in renal hypertensive rats.
Canadian journal of physiology and pharmacology 1991;69(9):1364-6.
1991: Okunishi H; Kawamoto T; Kurobe Y; Oka Y; Ishii K; Tanaka T; Miyazaki M
Pathogenetic role of vascular angiotensin-converting enzyme in the spontaneously hypertensive rat.
Clinical and experimental pharmacology & physiology 1991;18(9):649-59.
1991: Morishita R; Higaki J; Okunishi H; Tanaka T; Ishii K; Nagano M; Mikami H; Ogihara T; Murakami K; Miyazaki M
Changes in gene expression of the renin-angiotensin system in two-kidney, one clip hypertensive rats.
Journal of hypertension 1991;9(2):187-92.
1989: Miyazaki M; Etoh Y; Iizuka K; Toda N
An orally active renin inhibitor: cyclohexylnorstatine-containing dipeptide (KRI-1314).
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1989;7(2):S25-7.
1988: Miyazaki M; Okamura T; Toda N
Role of vascular angiotensin converting enzyme in hypertension.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(3):S13-5.

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