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Tohru Mizushima

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Ryota Tanaka; Hiroshi Watanabe; Tohru Mizushima; Masaki Otagiri; Ken-Ichiro Tanaka; Victor Tuan Giam Chuang; Keisuke Hamasaki; Yu Ishima; Azusa Kodama; Toru Maruyama
Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression.
Naoki Yamakawa; Toru Maruyama; Masami Ohtsuka; Yoshinari Okamoto; Shintaro Suemasu; Kayoko Tahara; Ken-Ichiro Tanaka; Hiroshi Watanabe; Tohru Mizushima
Comparison of Pharmacokinetics between Loxoprofen and Its Derivative with Lower Ulcerogenic Activity, Fluoro-loxoprofen.
Minoru Matsuda; Gen Sobue; Kayoko Tahara; Naoki Yamakawa; Hiroaki Adachi; Tatsuya Hoshino; Hironobu Ihn; Daisuke Maji; Tohru Mizushima
Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice.

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2013: Ryota Tanaka; Hiroshi Watanabe; Tohru Mizushima; Masaki Otagiri; Ken-Ichiro Tanaka; Victor Tuan Giam Chuang; Keisuke Hamasaki; Yu Ishima; Azusa Kodama; Toru Maruyama
Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression.
The Journal of pharmacology and experimental therapeutics 2013;345(2):271-83.
2013: Naoki Yamakawa; Toru Maruyama; Masami Ohtsuka; Yoshinari Okamoto; Shintaro Suemasu; Kayoko Tahara; Ken-Ichiro Tanaka; Hiroshi Watanabe; Tohru Mizushima
Comparison of Pharmacokinetics between Loxoprofen and Its Derivative with Lower Ulcerogenic Activity, Fluoro-loxoprofen.
Drug metabolism and pharmacokinetics 2013;28(2):118-24.
2013: Minoru Matsuda; Gen Sobue; Kayoko Tahara; Naoki Yamakawa; Hiroaki Adachi; Tatsuya Hoshino; Hironobu Ihn; Daisuke Maji; Tohru Mizushima
Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice.
The Journal of investigative dermatology 2013;133(4):919-28.
2013: Manabu Nakashita; Hidekazu Suzuki; Takao Taki; Keita Uehara; Soichiro Miura; Tohru Mizushima; Hiroshi Nagata; Toshifumi Hibi
Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors.
Digestive diseases and sciences 2013;58(2):354-62.
2012: Shintaro Suemasu; Hidekazu Suzuki; Kayoko Tahara; Koji Takeuchi; Ken-Ichiro Tanaka; Naoki Yamakawa; Teita Asano; Tomoaki Ishihara; Hirofumi Matsui; Yoshinari Okamoto; Masami Otsuka; Tohru Mizushima
Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity.
Biochemical pharmacology 2012;84(11):1470-81.
2012: Ken-Ichiro Tanaka; Keizo Sato; Arata Azuma; Yuri Miyazaki; Tohru Mizushima
Effects of lecithinized superoxide dismutase and/or pirfenidone against bleomycin-induced pulmonary fibrosis.
Chest 2012;142(4):1011-9.
2012: Ken-Ichiro Tanaka; Naoki Yamakawa; Yosuke Ito; Takushi Namba; Ayano Shirai; Kayoko Tahara; Tohru Mizushima
Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice.
Biochemical and biophysical research communications 2012;425(4):818-24.
2012: Ken-Ichiro Tanaka; Keizo Sato; Kazutetsu Aoshiba; Arata Azuma; Tohru Mizushima
Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice.
American journal of physiology. Lung cellular and molecular physiology 2012;302(12):L1250-61.
2012: Naoki Yamakawa; Teita Asano; Tomoaki Ishihara; Keishi Miyata; Yoshinari Okamoto; Masami Otsuka; Shintaro Suemasu; Ken-Ichiro Tanaka; Tohru Mizushima
Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.
Journal of medicinal chemistry 2012;55(11):5143-50.
2012: Tohru Mizushima
[Novel pharmacological effects of NSAIDs and their molecular mechanism].
Seikagaku. The Journal of Japanese Biochemical Society 2012;84(5):365-8.
2012: Teita Asano; Shin Fukudo; Tomoaki Ishihara; Shintaro Suemasu; Hidekazu Suzuki; Toshio Suzuki; Kayoko Tahara; Ken-ichiro Tanaka; Tohru Mizushima
Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity.
Biochemical and biophysical research communications 2012;420(2):444-9.
2012: Yasuhiro Yamashita; Tatsuya Hoshino; Tsuyoshi Ikeda; Daisuke Maji; Minoru Matsuda; Tohru Mizushima
Purification and characterization of HSP-inducers from Eupatorium lindleyanum.
Biochemical pharmacology 2012;83(7):909-22.
2012: Tohru Mizushima
[Identification of a molecular mechanism for actions of existing medicines and its application for drug development].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(6):713-20.
2011: Ken-Ichiro Tanaka; Yuta Tanaka; Takushi Namba; Keizo Sato; Kazutetsu Aoshiba; Arata Azuma; Yuri Miyazaki; Tohru Mizushima
Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema.
The Journal of pharmacology and experimental therapeutics 2011;338(3):810-8.
2011: Naoki Yamakawa; Shintaro Suemasu; Masaaki Matoyama; Ken-Ichiro Tanaka; Takashi Katsu; Keishi Miyata; Yoshinari Okamoto; Masami Otsuka; Tohru Mizushima
Synthesis and biological evaluation of loxoprofen derivatives.
Bioorganic & medicinal chemistry 2011;19(11):3299-311.
2011: Tohru Mizushima
Drug discovery and development focusing on existing medicines: drug re-profiling strategy.
Journal of biochemistry 2011;149(5):499-505.
2011: Masaya Takehara; Tatsuya Hoshino; Takushi Namba; Naoki Yamakawa; Tohru Mizushima
Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice.
Biochemical pharmacology 2011;81(9):1124-35.
2011: Tatsuya Hoshino; Naoya Murao; Takushi Namba; Masaya Takehara; Hiroaki Adachi; Masahisa Katsuno; Gen Sobue; Takahide Matsushima; Toshiharu Suzuki; Tohru Mizushima
Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(14):5225-34.
2011: Takushi Namba; Ken-Ichiro Tanaka; Arata Azuma; Tatsuya Hoshino; Tohru Mizushima
Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis.
PloS one 2011;6(11):e27296.
2010: Takushi Namba; Koichi Tanaka; Y Ito; Tatsuya Hoshino; M Matoyama; N Yamakawa; Y Isohama; A Azuma; Tohru Mizushima
Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis.
Cell death and differentiation 2010;17(12):1882-95.
2010: Takushi Namba; Tatsuya Hoshino; Shintaro Suemasu; Mika Takarada-Iemata; Osamu Hori; Naomi Nakagata; Akinori Yanaka; Tohru Mizushima
Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions.
The Journal of biological chemistry 2010;285(48):37302-13.
2010: Naoki Yamakawa; Shintaro Suemasu; Masaaki Matoyama; Ayumi Kimoto; Miho Takeda; Ken-Ichiro Tanaka; Tomoaki Ishihara; Takashi Katsu; Yoshinari Okamoto; Masami Otsuka; Tohru Mizushima
Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.
Journal of medicinal chemistry 2010;53(21):7879-82.
2010: Tsutomu Ishihara; Taishi Maeda; Haruka Sakamoto; Naoko Takasaki; Masao Shigyo; Tatsuhiro Ishida; Hiroshi Kiwada; Yutaka Mizushima; Tohru Mizushima
Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.
Biomacromolecules 2010;11(10):2700-6.
2010: Ken-Ichiro Tanaka; Yuta Tanaka; Takushi Namba; Arata Azuma; Tohru Mizushima
Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice.
Biochemical pharmacology 2010;80(6):920-31.
2010: Yasuhiro Yamashita; Tatsuya Hoshino; Minoru Matsuda; Chisa Kobayashi; Aya Tominaga; Yasuhiko Nakamura; Koumei Nakashima; Kazumi Yokomizo; Tsuyoshi Ikeda; Kazutaka Mineda; Daisuke Maji; Yoshimi Niwano; Tohru Mizushima
HSP70 inducers from Chinese herbs and their effect on melanin production.
Experimental dermatology 2010;19(8):e340-2.
2010: Tomoaki Ishihara; Ken-Ichiro Tanaka; Saki Tashiro; Kosuke Yoshida; Tohru Mizushima
Protective effect of rebamipide against celecoxib-induced gastric mucosal cell apoptosis.
Biochemical pharmacology 2010;79(11):1622-33.
2010: Tatsuya Hoshino; Minoru Matsuda; Yasuhiro Yamashita; Masaya Takehara; Masayo Fukuya; Kazutaka Mineda; Daisuke Maji; Hironobu Ihn; Hiroaki Adachi; Gen Sobue; Yoko Funasaka; Tohru Mizushima
Suppression of melanin production by expression of HSP70.
The Journal of biological chemistry 2010;285(17):13254-63.
2010: Ken-Ichiro Tanaka; Tomoaki Ishihara; Arata Azuma; Shoji Kudoh; Masahito Ebina; Toshihiro Nukiwa; Yukihiko Sugiyama; Yuichi Tasaka; Takushi Namba; Tsutomu Ishihara; Keizo Sato; Yutaka Mizushima; Tohru Mizushima
Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2010;298(3):L348-60.
2010: Minoru Matsuda; Tatsuya Hoshino; Yasuhiro Yamashita; Ken-ichiro Tanaka; Daisuke Maji; Keizo Sato; Hiroaki Adachi; Gen Sobue; Hironobu Ihn; Yoko Funasaka; Tohru Mizushima
Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70.
The Journal of biological chemistry 2010;285(8):5848-58.
2010: Tsutomu Ishihara; Miyuki Takahashi; Megumu Higaki; Yutaka Mizushima; Tohru Mizushima
Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents.
International journal of pharmaceutics 2010;385(1-2):170-5.
2010: Naoki Yamakawa; Shintaro Suemasu; Ayumi Kimoto; Yasuhiro Arai; Tomoaki Ishihara; Kazumi Yokomizo; Yoshinari Okamoto; Masami Otsuka; Ken-Ichiro Tanaka; Tohru Mizushima
Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
Biological & pharmaceutical bulletin 2010;33(3):398-403.
2010: Tohru Mizushima
HSP-dependent protection against gastrointestinal diseases.
Current pharmaceutical design 2010;16(10):1190-6.
2009: Ken-Ichiro Tanaka; Tohru Mizushima
Protective role of HSF1 and HSP70 against gastrointestinal diseases.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2009;25(8):668-76.
2009: Tsutomu Ishihara; Miho Takeda; Haruka Sakamoto; Ayumi Kimoto; Chisa Kobayashi; Naoko Takasaki; Kanae Yuki; Ken-ichiro Tanaka; Mitsuko Takenaga; Rie Igarashi; Taishi Maeda; Naoki Yamakawa; Yoshinari Okamoto; Masami Otsuka; Tatsuhiro Ishida; Hiroshi Kiwada; Yutaka Mizushima; Tohru Mizushima
Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.
Pharmaceutical research 2009;26(10):2270-9.
2009: Teita Asano; Ken-Ichiro Tanaka; Naoki Yamakawa; Hiroaki Adachi; Gen Sobue; Hidemi Goto; Koji Takeuchi; Tohru Mizushima
HSP70 confers protection against indomethacin-induced lesions of the small intestine.
The Journal of pharmacology and experimental therapeutics 2009;330(2):458-67.
2009: Shintaro Suemasu; Ken-Ichiro Tanaka; Takushi Namba; Tomoaki Ishihara; Takashi Katsu; Mitsuaki Fujimoto; Hiroaki Adachi; Gen Sobue; Koji Takeuchi; Akira Nakai; Tohru Mizushima
A role for HSP70 in protecting against indomethacin-induced gastric lesions.
The Journal of biological chemistry 2009;284(29):19705-15.
2009: Tatsuya Hoshino; Takushi Namba; Masaya Takehara; Tadashi Nakaya; Yukihiko Sugimoto; Wataru Araki; Shuh Narumiya; Toshiharu Suzuki; Tohru Mizushima
Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.
The Journal of biological chemistry 2009;284(27):18493-502.
2009: Miho Takeda; Taishi Maeda; Tsutomu Ishihara; Haruka Sakamoto; Kanae Yuki; Naoko Takasaki; Fumihiro Nishimura; Takeshi Yamashita; Ken-Ichiro Tanaka; Mitsuko Takenaga; Rie Igarashi; Megumu Higaki; Naoki Yamakawa; Yoshinari Okamoto; Hisao Ogawa; Masami Otsuka; Yutaka Mizushima; Tohru Mizushima
Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles.
Pharmaceutical research 2009;26(7):1792-800.
2009: Masaya Takehara; Tomoko Nishimura; Shinji Mima; Tatsuya Hoshino; Tohru Mizushima
Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells.
Biological & pharmaceutical bulletin 2009;32(5):825-31.
2009: Takushi Namba; Ken-Ichiro Tanaka; Yosuke Ito; Tomoaki Ishihara; Tatsuya Hoshino; Tomomi Gotoh; Motoyoshi Endo; Keizo Sato; Tohru Mizushima
Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis.
The American journal of pathology 2009;174(5):1786-98.
2009: Takushi Namba; Takashi Homan; Tomoko Nishimura; Shinji Mima; Tatsuya Hoshino; Tohru Mizushima
Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in anti-tumorigenic effects.
The Journal of biological chemistry 2009;284(7):4158-67.
2009: Masaki Makise; Masaya Takehara; Akihiko Kuniyasu; Nanako Matsui; Hitoshi Nakayama; Tohru Mizushima
Linkage between phosphorylation of the origin recognition complex and its ATP binding activity in Saccharomyces cerevisiae.
The Journal of biological chemistry 2009;284(6):3396-407.
2009: Ken-Ichiro Tanaka; Shintaro Suemasu; Tomoaki Ishihara; Yuichi Tasaka; Yasuhiro Arai; Tohru Mizushima
Inhibition of both COX-1 and COX-2 and resulting decrease in the level of prostaglandins E2 is responsible for non-steroidal anti-inflammatory drug (NSAID)-dependent exacerbation of colitis.
European journal of pharmacology 2009;603(1-3):120-32.
2008: Shinji Mima; Masaya Takehara; Hiroko Takada; Tomoko Nishimura; Tatsuya Hoshino; Tohru Mizushima
NSAIDs suppress the expression of claudin-2 to promote invasion activity of cancer cells.
Carcinogenesis 2008;29(10):1994-2000.
2008: Hironori Ushijima; Miki Hiasa; Takushi Namba; Hyun-Jung Hwang; Tatsuya Hoshino; Shinji Mima; Tomofusa Tsuchiya; Yoshinori Moriyama; Tohru Mizushima
Expression and function of TETRAN, a new type of membrane transporter.
Biochemical and biophysical research communications 2008;374(2):325-30.
2008: Masaya Takehara; Masaki Makise; Hitomi Takenaka; Teita Asano; Tohru Mizushima
Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro.
The Biochemical journal 2008;413(3):535-43.
2008: Masaki Makise; Nanako Matsui; Fumiko Yamairi; Naoko Takahashi; Masaya Takehara; Teita Asano; Tohru Mizushima
Analysis of origin recognition complex in saccharomyces cerevisiae by use of Degron mutants.
Journal of biochemistry 2008;143(4):455-65.
2008: Tohru Mizushima
[Strategy for development of NSAIDs with lower risk for side effects].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(2):255-61.
2008: Taira Matsuo; Jing Chen; Yusuke Minato; Wakano Ogawa; Tohru Mizushima; Teruo Kuroda; Tomofusa Tsuchiya
SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescens.
Journal of bacteriology 2008;190(2):648-54.
2007: Taira Matsuo; Katsuhiko Hayashi; Yuji Morita; Motohiro Koterasawa; Wakano Ogawa; Tohru Mizushima; Tomofusa Tsuchiya; Teruo Kuroda
VmeAB, an RND-type multidrug efflux transporter in Vibrio parahaemolyticus.
Microbiology (Reading, England) 2007;153(Pt 12):4129-37.
2007: Kazuya Matsuda; Masaki Makise; Yoshihiro Sueyasu; Masaya Takehara; Teita Asano; Tohru Mizushima
Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
FEMS yeast research 2007;7(8):1263-9.
2007: Teita Asano; Masaki Makise; Masaya Takehara; Tohru Mizushima
Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.
FEMS yeast research 2007;7(8):1256-62.
2007: Tatsuya Hoshino; Tadashi Nakaya; Takashi Homan; Ken-ichiro Tanaka; Yukihiko Sugimoto; Wataru Araki; Masami Narita; Shuh Narumiya; Toshiharu Suzuki; Tohru Mizushima
Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo.
The Journal of biological chemistry 2007;282(45):32676-88.
2007: Tohru Mizushima
[Protection of gastrointestinal mucosa against NSAID-induced ulcer].
Nihon rinsho. Japanese journal of clinical medicine 2007;65(10):1744-7.
2007: Ken-Ichiro Tanaka; Takushi Namba; Yasuhiro Arai; Mitsuaki Fujimoto; Hiroaki Adachi; Gen Sobue; Koji Takeuchi; Akira Nakai; Tohru Mizushima
Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis.
The Journal of biological chemistry 2007;282(32):23240-52.
2007: Tomoaki Ishihara; Tatsuya Hoshino; Takushi Namba; Ken-ichiro Tanaka; Tohru Mizushima
Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis.
Biochemical and biophysical research communications 2007;356(3):711-7.
2007: Takushi Namba; Tomoaki Ishihara; Ken-ichiro Tanaka; Tatsuya Hoshino; Tohru Mizushima
Transcriptional activation of ATF6 by endoplasmic reticulum stressors.
Biochemical and biophysical research communications 2007;355(2):543-8.
2007: Shinji Mima; Hironori Ushijima; Hyun-Jung Hwang; Shinji Tsutsumi; Masaki Makise; Yoshihiro Yamaguchi; Tomofusa Tsuchiya; Hiroshi Mizushima; Tohru Mizushima
Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs.
FEBS letters 2007;581(7):1457-63.
2007: Tohru Mizushima
Various stress proteins protect gastric mucosal cells against non-steroidal anti-inflammatory drugs.
Inflammopharmacology 2007;15(2):67-73.
2007: Fereshteh Shahcheraghi; Yusuke Minato; Jing Chen; Tohru Mizushima; Wakano Ogawa; Teruo Kuroda; Tomofusa Tsuchiya
Molecular cloning and characterization of a multidrug efflux pump, SmfY, from Serratia marcescens.
Biological & pharmaceutical bulletin 2007;30(4):798-800.
2007: Ken-Ichiro Tanaka; Shinji Tsutsumi; Yasuhiro Arai; Tatsuya Hoshino; Keitarou Suzuki; Eiichi Takaki; Takaaki Ito; Koji Takeuchi; Akira Nakai; Tohru Mizushima
Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions.
Molecular pharmacology 2007;71(4):985-93.
2007: Tatsuya Hoshino; Tadashi Nakaya; Wataru Araki; Keitarou Suzuki; Toshiharu Suzuki; Tohru Mizushima
Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.
The Biochemical journal 2007;402(3):581-9.
2007: Takushi Namba; Tatsuya Hoshino; Ken-ichiro Tanaka; Shinji Tsutsumi; Tomoaki Ishihara; Shinji Mima; Keitarou Suzuki; Satoshi Ogawa; Tohru Mizushima
Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells.
Molecular pharmacology 2007;71(3):860-70.
2007: Masaki Makise; Naoko Takahashi; Kazuya Matsuda; Fumiko Yamairi; Keitarou Suzuki; Tomofusa Tsuchiya; Tohru Mizushima
Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.
The Biochemical journal 2007;402(2):397-403.
2006: Mayuko Aburaya; Ken-Ichiro Tanaka; Tatsuya Hoshino; Shinji Tsutsumi; Keitarou Suzuki; Masaki Makise; Reiko Akagi; Tohru Mizushima
Heme oxygenase-1 protects gastric mucosal cells against non-steroidal anti-inflammatory drugs.
The Journal of biological chemistry 2006;281(44):33422-32.
2006: Youichi Yamada; Sumiko Shiota; Tohru Mizushima; Teruo Kuroda; Tomofusa Tsuchiya
Functional gene cloning and characterization of MdeA, a multidrug efflux pump from Staphylococcus aureus.
Biological & pharmaceutical bulletin 2006;29(4):801-4.
2006: Shinji Tsutsumi; Takushi Namba; Ken-ichiro Tanaka; Yasuhiro Arai; Tomoaki Ishihara; Mayuko Aburaya; Shinji Mima; Tatsuya Hoshino; Tohru Mizushima
Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells.
Oncogene 2006;25(7):1018-29.
2005: Xian-Zhong Su; Jing Chen; Tohru Mizushima; Teruo Kuroda; Tomofusa Tsuchiya
AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters.
Antimicrobial agents and chemotherapy 2005;49(10):4362-4.
2005: Wataru Tomisato; Ken-Ichiro Tanaka; Shinji Tsutsumi; Tatsuya Hoshino; Kazumi Yokomizo; Keitarou Suzuki; Takashi Katsu; Tohru Mizushima; Tohru Mizushima
Low direct cytotoxicity and cytoprotective effects of nitric oxide releasing indomethacin.
Digestive diseases and sciences 2005;50(10):1927-37.
2005: Hironori Ushijima; Ken-Ichiiro Tanaka; Miho Takeda; Takashi Katsu; Shinji Mima; Tohru Mizushima
Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs.
Molecular pharmacology 2005;68(4):1156-61.
2005: Ken-Ichiro Tanaka; Wataru Tomisato; Tatsuya Hoshino; Tomoaki Ishihara; Takushi Namba; Mayuko Aburaya; Takashi Katsu; Keitarou Suzuki; Shinji Tsutsumi; Tohru Mizushima
Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis.
The Journal of biological chemistry 2005;280(35):31059-67.
2005: Yasuhiro Arai; Ken-Ichiro Tanaka; Hironori Ushijima; Wataru Tomisato; Shinji Tsutsumi; Mayuko Aburaya; Tatsuya Hoshino; Kazumi Yokomizo; Keitarou Suzuki; Takashi Katsu; Tomofusa Tsuchiya; Tohru Mizushima
Low direct cytotoxicity of nabumetone on gastric mucosal cells.
Digestive diseases and sciences 2005;50(9):1641-6.
2005: Wakano Ogawa; Dai-Wei Li; Ping Yu; Anowara Begum; Tohru Mizushima; Teruo Kuroda; Tomofusa Tsuchiya
Multidrug resistance in Klebsiella pneumoniae MGH78578 and cloning of genes responsible for the resistance.
Biological & pharmaceutical bulletin 2005;28(8):1505-8.
2005: Keitarou Suzuki; Tadashi Okawara; Tatuya Higashijima; Kazumi Yokomizo; Tohru Mizushima; Masami Otsuka
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships.
Bioorganic & medicinal chemistry letters 2005;15(8):2065-8.
2005: Shinji Mima; Shinji Tsutsumi; Hironori Ushijima; Miho Takeda; Ikue Fukuda; Kazumi Yokomizo; Keitarou Suzuki; Kuniaki Sano; Tohru Nakanishi; Wataru Tomisato; Tomofusa Tsuchiya; Tohru Mizushima
Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.
Cancer research 2005;65(5):1868-76.
2005: Takehiko Mima; Hiroshi Sekiya; Tohru Mizushima; Teruo Kuroda; Tomofusa Tsuchiya
Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.
Microbiology and immunology 2005;49(11):999-1002.
2005: Anowara Begum; M Mushfequr Rahman; Wakano Ogawa; Tohru Mizushima; Teruo Kuroda; Tomofusa Tsuchiya
Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1.
Microbiology and immunology 2005;49(11):949-57.
2005: Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Physiological roles of three Na+/H+ antiporters in the halophilic bacterium Vibrio parahaemolyticus.
Microbiology and immunology 2005;49(8):711-9.
2005: Mai Fujita; Sumiko Shiota; Teruo Kuroda; Tsutomu Hatano; Takashi Yoshida; Tohru Mizushima; Tomofusa Tsuchiya
Remarkable synergies between baicalein and tetracycline, and baicalein and beta-lactams against methicillin-resistant Staphylococcus aureus.
Microbiology and immunology 2005;49(4):391-6.
2004: Wataru Tomisato; Ken-ichiro Tanaka; Takashi Katsu; Hiroki Kakuta; Kenji Sasaki; Shinji Tsutsumi; Tatsuya Hoshino; Mayuko Aburaya; Daiwei Li; Tomofusa Tsuchiya; Keitarou Suzuki; Kazumi Yokomizo; Tohru Mizushima
Membrane permeabilization by non-steroidal anti-inflammatory drugs.
Biochemical and biophysical research communications 2004;323(3):1032-9.
2004: Shinji Tsutsumi; T Gotoh; Wataru Tomisato; Shinji Mima; T Hoshino; Hyun-Jung Hwang; H Takenaka; T Tsuchiya; M Mori; Tohru Mizushima
Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis.
Cell death and differentiation 2004;11(9):1009-16.
2004: Ken-Ichiro Tanaka; Wataru Tomisato; Shinji Tsutsumi; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Cytotoxic synergy between indomethacin and hydrochloric acid in gastric mucosal cells.
Biological & pharmaceutical bulletin 2004;27(8):1188-92.
2004: Hitomi Takenaka; Masaki Makise; Wakako Kuwae; Naoko Takahashi; Tomofusa Tsuchiya; Tohru Mizushima
ADP-binding to origin recognition complex of Saccharomyces cerevisiae.
Journal of molecular biology 2004;340(1):29-37.
2004: Naoko Takahashi; Yoshihiro Yamaguchi; Fumiko Yamairi; Masaki Makise; Hitomi Takenaka; Tomofusa Tsuchiya; Tohru Mizushima
Analysis on origin recognition complex containing Orc5p with defective Walker A motif.
The Journal of biological chemistry 2004;279(9):8469-77.
2004: Ken-Ichiro Tanaka; Kiyo Nishimoto; Wataru Tomisato; Shinji Tsutsumi; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Adaptive cytoprotection induced by pretreatment with ethanol protects against gastric cell damage by NSAIDs.
Digestive diseases and sciences 2004;49(2):210-7.
2004: Wataru Tomisato; Shinji Tsutsumi; Tatsuya Hoshino; Hyun-Jung Hwang; Mitsunobu Mio; Tomofusa Tsuchiya; Tohru Mizushima
Role of direct cytotoxic effects of NSAIDs in the induction of gastric lesions.
Biochemical pharmacology 2004;67(3):575-85.
2004: Teruo Kuroda; Naoko Fujita; Junko Utsugi; Masayuki Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
A major Li(+) extrusion system NhaB of Pseudomonas aeruginosa : comparison with the major Na(+) extrusion system NhaP.
Microbiology and immunology 2004;48(4):243-50.
2004: Gui-Xin He; Teruo Kuroda; Takehiko Mima; Yuji Morita; Tohru Mizushima; Tomofusa Tsuchiya
An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa.
Journal of bacteriology 2004;186(1):262-5.
2003: Eun-Woo Lee; Md Nazmul Huda; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
EfrAB, an ABC multidrug efflux pump in Enterococcus faecalis.
Antimicrobial agents and chemotherapy 2003;47(12):3733-8.
2003: Masaki Makise; Hitomi Takenaka; Wakako Kuwae; Naoko Takahashi; Tomofusa Tsuchiya; Tohru Mizushima
Kinetics of ATP binding to the origin recognition complex of Saccharomyces cerevisiae.
The Journal of biological chemistry 2003;278(47):46440-5.
2003: Shinji Tsutsumi; Shinji Mima; Wataru Tomisato; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Molecular mechanism of adaptive cytoprotection induced by ethanol in human gastric cells.
Experimental biology and medicine (Maywood, N.J.) 2003;228(9):1089-95.
2003: Yang Li; Takehiko Mima; Yukiko Komori; Yuji Morita; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy 2003;52(4):572-5.
2003: Hiroshi Sekiya; Takehiko Mima; Yuji Morita; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Functional cloning and characterization of a multidrug efflux pump, mexHI-opmD, from a Pseudomonas aeruginosa mutant.
Antimicrobial agents and chemotherapy 2003;47(9):2990-2.
2003: Nazmul Huda; Eun-Woo Lee; Jing Chen; Yuji Morita; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in Non-O1 Vibrio cholerae.
Antimicrobial agents and chemotherapy 2003;47(8):2413-7.
2003: Jing Chen; Teruo Kuroda; Md Nazmul Huda; Tohru Mizushima; Tomofusa Tsuchiya
An RND-type multidrug efflux pump SdeXY from Serratia marcescens.
The Journal of antimicrobial chemotherapy 2003;52(2):176-9.
2003: Tatsuya Hoshino; Shinji Tsutsumi; Wataru Tomisato; Hyun-Jung Hwang; Tomofusa Tsuchiya; Tohru Mizushima
Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation.
The Journal of biological chemistry 2003;278(15):12752-8.
2003: Yuji Morita; Takeshi Murata; Takehiko Mima; Sumiko Shiota; Teruo Kuroda; Tohru Mizushima; Naomasa Gotoh; Takeshi Nishino; Tomofusa Tsuchiya
Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1.
The Journal of antimicrobial chemotherapy 2003;51(4):991-4.
2003: Jing Chen; Eun-Woo Lee; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Multidrug resistance in Serratia marcescens and cloning of genes responsible for the resistance.
Biological & pharmaceutical bulletin 2003;26(3):391-3.
2003: Eun-Woo Lee; Jing Chen; Md Nazmul Huda; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Functional cloning and expression of emeA, and characterization of EmeA, a multidrug efflux pump from Enterococcus faecalis.
Biological & pharmaceutical bulletin 2003;26(2):266-70.
2003: Xing-Jue Xu; Xian-Zhong Su; Yuji Morita; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Molecular cloning and characterization of the HmrM multidrug efflux pump from Haemophilus influenzae Rd.
Microbiology and immunology 2003;47(12):937-43.
2003: Md Nazmul Huda; Jing Chen; Yuji Morita; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Gene cloning and characterization of VcrM, a Na+-coupled multidrug efflux pump, from Vibrio cholerae non-O1.
Microbiology and immunology 2003;47(6):419-27.
2003: Tatsuya Hoshino; Tatsunori Takano; Wataru Tomisato; Shinji Tsutsumi; Hyun-Jung Hwang; Yuko Koura; Kiyo Nishimoto; Tomofusa Tsuchiya; Tohru Mizushima
Effects of sucralfate on gastric irritant-induced necrosis and apoptosis in cultured guinea pig gastric mucosal cells.
Biological & pharmaceutical bulletin 2003;26(1):24-7.
2002: Tatsuya Hoshino; Tatsunori Takano; Shinji Tsutsumi; Wataru Tomisato; Tomofusa Tsuchiya; Tohru Mizushima
Effects of prostaglandin E2 on gastric irritant-induced apoptosis.
Digestive diseases and sciences 2002;47(10):2370-9.
2002: Masaki Makise; Shinji Mima; Takashi Katsu; Tomofusa Tsuchiya; Tohru Mizushima
Acidic phospholipids inhibit the DNA-binding activity of DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli.
Molecular microbiology 2002;46(1):245-56.
2002: Wataru Tomisato; Tatsuya Hoshino; Shinji Tsutsumi; Tomofusa Tsuchiya; Tohru Mizushima
Maturation-associated increase in sensitivity of cultured guinea pig gastric pit cells to hydrogen peroxide.
Digestive diseases and sciences 2002;47(9):2125-33.
2002: Shinji Mima; Masaki Makise; Motohiro Koterasawa; Tomofusa Tsuchiya; Tohru Mizushima
Conserved hydrophobic amino acid residues in the N-terminal region of DnaA protein are involved in DnaA-DnaA interaction.
The Biochemical journal 2002;365(Pt 3):881-7.
2002: Tatsunori Takano; Shinji Tsutsumi; Wataru Tomisato; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced apoptosis.
Digestive diseases and sciences 2002;47(7):1546-53.
2002: Motohiro Koterasawa; Shinji Mima; Masaki Makise; Tomofusa Tsuchiya; Tohru Mizushima
Mutational analysis of conserved hydrophobic amino acid residues in the N-terminal region of DnaA protein.
Biological & pharmaceutical bulletin 2002;25(7):913-5.
2002: Young-Mog Kim; Wakano Ogawa; Eiji Tamai; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Purification, reconstitution, and characterization of Na(+)/serine symporter, SstT, of Escherichia coli.
Journal of biochemistry 2002;132(1):71-6.
2002: Shinji Tsutsumi; Wataru Tomisato; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Transforming growth factor-beta1 is responsible for maturation-dependent spontaneous apoptosis of cultured gastric pit cells.
Experimental biology and medicine (Maywood, N.J.) 2002;227(6):402-11.
2002: Naoko Takahashi; Shinji Tsutsumi; Tomofusa Tsuchiya; Bruce Stillman; Tohru Mizushima
Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro.
The Journal of biological chemistry 2002;277(18):16033-40.
2002: Hitomi Takenaka; Naoko Takahashi; Jong-Ryul Lee; Masaki Makise; Yoshihiro Yamaguchi; Tomofusa Tsuchiya; Tohru Mizushima
Effects of adenine-nucleotides on the sequence-specificity of origin recognition complex-binding to DNA.
Biological & pharmaceutical bulletin 2002;25(5):652-5.
2002: Shinji Tsutsumi; Wataru Tomisato; Tatsunori Takano; Kazuhito Rokutan; Tomofusa Tsuchiya; Tohru Mizushima
Gastric irritant-induced apoptosis in guinea pig gastric mucosal cells in primary culture.
Biochimica et biophysica acta 2002;1589(2):168-80.
2002: Jong-Ryul Lee; Hitomi Takenaka; Naoko Takahashi; Masaki Makise; Yoshihiro Yamaguchi; Tomofusa Tsuchiya; Tohru Mizushima
Acidic phospholipids with unsaturated fatty acids inhibit the binding of origin recognition complex to origin DNA.
Journal of biochemistry 2002;131(4):541-6.
2002: Masaki Makise; Tomofusa Tsuchiya; Tohru Mizushima
Sequence-independent DNA binding activity of DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli.
Journal of biochemistry 2002;131(3):419-25.
2002: Masaki Makise; Shinji Mima; Motohiro Koterasawa; Tomofusa Tsuchiya; Tohru Mizushima
Biochemical analysis of DnaA protein with mutations in both Arg328 and Lys372.
The Biochemical journal 2002;362(Pt 2):453-8.
2002: Jong-Ryul Lee; Masaki Makise; Hitomi Takenaka; Naoko Takahashi; Yoshihiro Yamaguchi; Tomofusa Tsuchiya; Tohru Mizushima
Inhibitory effects of acidic phospholipids on the binding of origin-recognition complex to origin DNA.
The Biochemical journal 2002;362(Pt 2):395-9.
2002: Shinji Tsutsumi; Reiko Haruna; Wataru Tomisato; Tatsunori Takano; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Effects of prostaglandins on spontaneous apoptosis in gastric mucosal cells.
Digestive diseases and sciences 2002;47(1):84-9.
2002: Jing Chen; Yuji Morita; Md Nazmul Huda; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
VmrA, a member of a novel class of Na(+)-coupled multidrug efflux pumps from Vibrio parahaemolyticus.
Journal of bacteriology 2002;184(2):572-6.
2001: T Gouda; M Kuroda; T Hiramatsu; K Nozaki; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
nhaG Na(+)/H(+) antiporter gene of Bacillus subtilis ATCC9372, which is missing in the complete genome sequence of strain 168, and properties of the antiporter.
Journal of biochemistry 2001;130(5):711-7.
2001: M Shimizu; Sumiko Shiota; Tohru Mizushima; H Ito; Tsutomu Hatano; Takashi Yoshida; Tomofusa Tsuchiya
Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin.
Antimicrobial agents and chemotherapy 2001;45(11):3198-201.
2001: Md Nazmul Huda; Yuji Morita; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Na+-driven multidrug efflux pump VcmA from Vibrio cholerae non-O1, a non-halophilic bacterium.
FEMS microbiology letters 2001;203(2):235-9.
2001: Yuji Morita; Y Komori; T Mima; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
Construction of a series of mutants lacking all of the four major mex operons for multidrug efflux pumps or possessing each one of the operons from Pseudomonas aeruginosa PAO1: MexCD-OprJ is an inducible pump.
FEMS microbiology letters 2001;202(1):139-43.
2001: Wataru Tomisato; Shinji Tsutsumi; Tomofusa Tsuchiya; Tohru Mizushima
Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced necrosis by induction of heat-shock proteins.
Biological & pharmaceutical bulletin 2001;24(8):887-91.
2001: Masaki Makise; Shinji Mima; Tomofusa Tsuchiya; Tohru Mizushima
Molecular mechanism for functional interaction between DnaA protein and acidic phospholipids: identification of important amino acids.
The Journal of biological chemistry 2001;276(10):7450-6.
2000: Yuji Morita; A Kataoka; Sumiko Shiota; Tohru Mizushima; Tomofusa Tsuchiya
NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump.
Journal of bacteriology 2000;182(23):6694-7.
2000: Wataru Tomisato; N Takahashi; C Komoto; Kazuhito Rokutan; Tomofusa Tsuchiya; Tohru Mizushima
Geranylgeranylacetone protects cultured guinea pig gastric mucosal cells from indomethacin.
Digestive diseases and sciences 2000;45(8):1674-9.
2000: T Kondo; Shinji Mima; Nobuko Fukuma; Kazuhisa Sekimizu; Tomofusa Tsuchiya; Tohru Mizushima
Suppression of temperature-sensitivity of a dnaA46 mutant by excessive DNA supercoiling.
The Biochemical journal 2000;348 Pt 2():375-9.
2000: Y Masaoka; Y Ueno; Yuji Morita; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
A two-component multidrug efflux pump, EbrAB, in Bacillus subtilis.
Journal of bacteriology 2000;182(8):2307-10.
2000: Masaki Makise; Shinji Mima; Tomofusa Tsuchiya; Tohru Mizushima
Identification of amino acids involved in the functional interaction between DnaA protein and acidic phospholipids.
The Journal of biological chemistry 2000;275(6):4513-8.
2000: Shinji Tsutsumi; Kazuhito Rokutan; Tomofusa Tsuchiya; Tohru Mizushima
Spontaneous apoptotic DNA fragmentation in cultured guinea pig gastric mucosal cells.
Digestive diseases and sciences 2000;45(2):291-7.
2000: Tohru Mizushima
Site-directed mutational analysis of DnaA protein, the initiator of chromosomal DNA replication in E. coli.
Journal of biochemistry 2000;127(1):1-7.
1999: Sumiko Shiota; M Shimizu; Tohru Mizushima; H Ito; Tsutomu Hatano; Takashi Yoshida; Tomofusa Tsuchiya
Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis).
Biological & pharmaceutical bulletin 1999;22(12):1388-90.
1999: Masaki Makise; K Sakamoto; Tomofusa Tsuchiya; Tohru Mizushima
Identification of a high-copy-number plasmid suppressor of a lethal phenotype caused by mutant DnaA protein which has decreased intrinsic ATPase activity.
Biological & pharmaceutical bulletin 1999;22(9):904-9.
1999: Shinji Tsutsumi; Kazuhito Rokutan; Tomofusa Tsuchiya; Tohru Mizushima
Geranylgeranylacetone suppresses spontaneous apoptotic DNA fragmentation in cultured guinea pig gastric pit cells.
Biological & pharmaceutical bulletin 1999;22(8):886-7.
1999: Shinji Mima; Y Yamagachi; T Kondo; Tomofusa Tsuchiya; Tohru Mizushima
Role of the amino-terminal region of the DnaA protein in opening of the duplex DNA at the oriC region.
FEMS microbiology letters 1999;176(1):163-7.
1999: Yoshihiro Yamaguchi; M Hase; Masaki Makise; Shinji Mima; T Yoshimi; Y Ishikawa; Tomofusa Tsuchiya; Tohru Mizushima
Involvement of Arg-328, Arg-334 and Arg-342 of DnaA protein in the functional interaction with acidic phospholipids.
The Biochemical journal 1999;340 ( Pt 2)():433-8.
1999: Tohru Mizushima; Shinji Tsutsumi; Kazuhito Rokutan; Tomofusa Tsuchiya
Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells.
Digestive diseases and sciences 1999;44(3):510-4.
1999: T Mine; Yuji Morita; A Kataoka; Tohru Mizushima; Tomofusa Tsuchiya
Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 1999;43(2):415-7.
1998: Wakano Ogawa; Young-Mog Kim; Tohru Mizushima; Tomofusa Tsuchiya
Cloning and expression of the gene for the Na+-coupled serine transporter from Escherichia coli and characteristics of the transporter.
Journal of bacteriology 1998;180(24):6749-52.
1998: T Hiramatsu; K Kodama; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
A putative multisubunit Na+/H+ antiporter from Staphylococcus aureus.
Journal of bacteriology 1998;180(24):6642-8.
1998: A Ohba; R Inoue; Nobuyoshi Akimitsu; Tohru Mizushima; Kazuhisa Sekimizu
Identification of proteins whose amounts are altered by mutation in the pgsA gene of Escherichia coli.
Biological & pharmaceutical bulletin 1998;21(11):1139-41.
1998: M Hase; T Yoshimi; Y Ishikawa; A Ohba; L Guo; Shinji Mima; Masaki Makise; Y Yamaguchi; T Tsuchiya; Tohru Mizushima
Site-directed mutational analysis for the membrane binding of DnaA protein. Identification of amino acids involved in the functional interaction between DnaA protein and acidic phospholipids.
The Journal of biological chemistry 1998;273(44):28651-6.
1998: Tohru Mizushima; T Takaki; Toshio Kubota; T Tsuchiya; T Miki; Tsutomu Katayama; Kazuhisa Sekimizu
Site-directed mutational analysis for the ATP binding of DnaA protein. Functions of two conserved amino acids (Lys-178 and Asp-235) located in the ATP-binding domain of DnaA protein in vitro and in vivo.
The Journal of biological chemistry 1998;273(33):20847-51.
1998: Eiji Tamai; T Shimamoto; M Tsuda; Tohru Mizushima; Tomofusa Tsuchiya
Conversion of temperature-sensitive to -resistant gene expression due to mutations in the promoter region of the melibiose operon in Escherichia coli.
The Journal of biological chemistry 1998;273(27):16860-4.
1998: E Suzuki; T Kondo; Masaki Makise; Shinji Mima; K Sakamoto; T Tsuchiya; Tohru Mizushima
Alteration in levels of unsaturated fatty acids in mutants of Escherichia coli defective in DNA replication.
Biological & pharmaceutical bulletin 1998;21(7):657-61.
1998: Yuji Morita; K Kodama; Sumiko Shiota; T Mine; A Kataoka; Tohru Mizushima; Tomofusa Tsuchiya
NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli.
Antimicrobial agents and chemotherapy 1998;42(7):1778-82.
1998: T Mine; Yuji Morita; A Kataoka; Tohru Mizushima; Tomofusa Tsuchiya
Evidence for chloramphenicol/H+ antiport in Cmr (MdfA) system of Escherichia coli and properties of the antiporter.
Journal of biochemistry 1998;124(1):187-93.
1998: E Suzuki; T Kondo; Masaki Makise; Shinji Mima; K Sakamoto; T Tsuchiya; Tohru Mizushima
Alteration in the contents of unsaturated fatty acids in dnaA mutants of Escherichia coli.
Molecular microbiology 1998;28(1):95-102.
1998: M Hase; Y Ishikawa; Kazuhisa Sekimizu; T Tsuchiya; Tohru Mizushima
Effect of glycerol on the affinity of DnaA protein for ATP in the presence of cardiolipin.
Journal of biochemistry 1998;123(4):680-3.
1998: K Nozaki; Teruo Kuroda; Tohru Mizushima; Tomofusa Tsuchiya
A new Na+/H+ antiporter, NhaD, of Vibrio parahaemolyticus.
Biochimica et biophysica acta 1998;1369(2):213-20.
1998: K Kurokawa; Tohru Mizushima; Toshio Kubota; T Tsuchiya; Tsutomu Katayama; Kazuhisa Sekimizu
A stimulation factor for hydrolysis of ATP bound to DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli.
Biochemical and biophysical research communications 1998;243(1):90-5.
1998: K Sakamoto; Masaki Makise; Tomofusa Tsuchiya; Tohru Mizushima
Effect of environmental factors on the dominant lethality caused by expression of a mutated DnaA protein with decreased intrinsic ATPase activity.
FEMS microbiology letters 1998;159(1):93-7.
1997: Wakano Ogawa; T Kayahara; M Tsuda; Tohru Mizushima; Tomofusa Tsuchiya
Isolation and characterization of an Escherichia coli mutant lacking the major serine transporter, and cloning of a serine transporter gene.
Journal of biochemistry 1997;122(6):1241-5.
1997: G H Shah; K Kataoka; A Ueno; Y Ohtsuka; Tohru Mizushima; Kazuhisa Sekimizu
Psychotropic drugs and local anesthetics restore cardiolipin-inhibited mammalian DNA topoisomerase I activity.
Biological & pharmaceutical bulletin 1997;20(12):1233-4.
1997: Teruo Kuroda; T Shimamoto; Tohru Mizushima; Tomofusa Tsuchiya
Mutational analysis of amiloride sensitivity of the NhaA Na+/H+ antiporter from Vibrio parahaemolyticus.
Journal of bacteriology 1997;179(23):7600-2.
1997: Y Ogata; R Inoue; Tohru Mizushima; Y Kano; T Miki; Kazuhisa Sekimizu
Heat shock-induced excessive relaxation of DNA in Escherichia coli mutants lacking the histone-like protein HU.
Biochimica et biophysica acta 1997;1353(3):298-306.
1997: Tohru Mizushima; K Yokoyama; S Mima; T Tsuchiya; Kazuhisa Sekimizu
Inhibition of thymidine transport in dnaA mutants of Escherichia coli.
The Journal of biological chemistry 1997;272(34):21195-200.
1997: Tsutomu Katayama; Nobuyoshi Akimitsu; Tohru Mizushima; T Miki; Kazuhisa Sekimizu
Overinitiation of chromosome replication in the Escherichia coli dnaAcos mutant depends on activation of oriC function by the dam gene product.
Molecular microbiology 1997;25(4):661-70.
1997: H Katayama; Tohru Mizushima; T Miki; Kazuhisa Sekimizu
Molecular cloning and sequence analysis of the dnaA gene of Staphylococcus aureus.
Biological & pharmaceutical bulletin 1997;20(7):820-2.
1997: Tohru Mizushima; Satoshi Nishida; K Kurokawa; Tsutomu Katayama; T Miki; Kazuhisa Sekimizu
Negative control of DNA replication by hydrolysis of ATP bound to DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli.
The EMBO journal 1997;16(12):3724-30.
1997: S Nishida; Tohru Mizushima; T Miki; Kazuhisa Sekimizu
Immotile phenotype of an Escherichia coli mutant lacking the histone-like protein HU.
FEMS microbiology letters 1997;150(2):297-301.
1997: Y Ohtsuka; Tohru Mizushima; T Miki; Kazuhisa Sekimizu
Transient DNA relaxation in Escherichia coli induced by nalidixic acid.
Biological & pharmaceutical bulletin 1997;20(5):467-70.
1997: Tohru Mizushima; R Koyanagi; T Katayama; T Miki; Kazuhisa Sekimizu
Decrease in expression of the master operon of flagellin synthesis in a dnaA46 mutant of Escherichia coli.
Biological & pharmaceutical bulletin 1997;20(4):327-31.
1997: A Ohba; Tohru Mizushima; T Katayama; Kazuhisa Sekimizu
Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
FEBS letters 1997;404(2-3):125-8.
1997: Toshio Kubota; Tsutomu Katayama; Yushi Ito; Tohru Mizushima; Kazuhisa Sekimizu
Conformational transition of DnaA protein by ATP: structural analysis of DnaA protein, the initiator of Escherichia coli chromosome replication.
Biochemical and biophysical research communications 1997;232(1):130-5.
1997: Tohru Mizushima; K Kataoka; Y Ogata; R Inoue; Kazuhisa Sekimizu
Increase in negative supercoiling of plasmid DNA in Escherichia coli exposed to cold shock.
Molecular microbiology 1997;23(2):381-6.
1997: Tohru Mizushima; M Matsuo; Kazuhisa Sekimizu
Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.
Antimicrobial agents and chemotherapy 1997;41(1):193-5.
1996: Tohru Mizushima; Y Ohtsuka; H Mori; T Miki; Kazuhisa Sekimizu
Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli.
Molecular & general genetics : MGG 1996;253(3):297-302.
1996: Y Ogata; Tohru Mizushima; K Kataoka; Katsuhiro Kita; T Miki; Kazuhisa Sekimizu
DnaK heat shock protein of Escherichia coli maintains the negative supercoiling of DNA against thermal stress.
The Journal of biological chemistry 1996;271(46):29407-14.
1996: Tohru Mizushima; S Sasaki; H Ohishi; M Kobayashi; Tsutomu Katayama; T Miki; M Maeda; Kazuhisa Sekimizu
Molecular design of inhibitors of in vitro oriC DNA replication based on the potential to block the ATP binding of DnaA protein.
The Journal of biological chemistry 1996;271(41):25178-83.
1996: K Kataoka; Tohru Mizushima; Y Ogata; T Miki; Kazuhisa Sekimizu
Heat shock-induced DNA relaxation in vitro by DNA gyrase of Escherichia coli in the presence of ATP.
The Journal of biological chemistry 1996;271(40):24806-10.
1996: Nobuyoshi Akimitsu; Tohru Mizushima; E Suzuki; T Miki; Kazuhisa Sekimizu
Growth phenotypes of Escherichia coli carrying a mutation of acidic phospholipid synthesis.
Biological & pharmaceutical bulletin 1996;19(10):1275-8.
1996: Tohru Mizushima; T Katayama; Kazuhisa Sekimizu
Effect on DNA topology by DnaA protein, the initiation factor of chromosomal DNA replication in Escherichia coli.
Biochemistry 1996;35(35):11512-6.
1996: M Matsuo; Y Ohtsuka; K Kataoka; Tohru Mizushima; Kazuhisa Sekimizu
Transient relaxation of plasmid DNA in Escherichia coli by fluoroquinolones.
The Journal of pharmacy and pharmacology 1996;48(9):985-7.
1996: Tohru Mizushima; T Shinpuku; H Katayama; K Kataoka; L Guo; T Miki; Kazuhisa Sekimizu
Phenotypes of dnaA mutants of Escherichia coli sensitive to phenothiazine derivatives.
Molecular & general genetics : MGG 1996;252(1-2):212-5.
1996: K Kurokawa; Tohru Mizushima; T Miki; Kazuhisa Sekimizu
Influence of the linking number of template DNA on sigma 32-dependent transcription initiation in vitro of the Escherichia coli groE gene.
Biological & pharmaceutical bulletin 1996;19(7):922-31.
1996: T Kaneko; Tohru Mizushima; Y Ohtsuka; K Kurokawa; K Kataoka; T Miki; Kazuhisa Sekimizu
Co-induction of DNA relaxation and synthesis of DnaK and GroEL proteins in Escherichia coli by expression of LetD (CcdB) protein, an inhibitor of DNA gyrase encoded by the F factor.
Molecular & general genetics : MGG 1996;250(5):593-600.
1996: Tohru Mizushima; Y Ishikawa; E Obana; M Hase; Toshio Kubota; Tsutomu Katayama; T Kunitake; E Watanabe; Kazuhisa Sekimizu
Influence of cluster formation of acidic phospholipids on decrease in the affinity for ATP of DnaA protein.
The Journal of biological chemistry 1996;271(7):3633-8.
1996: Tohru Mizushima; J Tanino; T Miki; Kazuhisa Sekimizu
Decrease in the linking number of plasmid DNA in dnaA mutants of Escherichia coli.
Biochemical and biophysical research communications 1996;218(1):137-41.
1995: Tohru Mizushima; R Koyanagi; E Suzuki; A Tomura; K Kutsukake; T Miki; Kazuhisa Sekimizu
Control by phosphatidylglycerol of expression of the flhD gene in Escherichia coli.
Biochimica et biophysica acta 1995;1245(3):397-401.
1995: M Hase; Tohru Mizushima; Tsutomu Katayama; Kazuhisa Sekimizu
Isolation and characterization of inhibitory factors of DNA polymerase III holoenzyme from Escherichia coli.
FEMS microbiology letters 1995;130(2-3):215-20.
1995: T Shinpuku; Tohru Mizushima; L Guo; T Miki; Kazuhisa Sekimizu
Phenotypes of dnaA mutants of Escherichia coli sensitive to detergents and organic solvents.
Biochemical and biophysical research communications 1995;212(1):84-9.
1994: Y Ogata; Tohru Mizushima; K Kataoka; T Miki; Kazuhisa Sekimizu
Identification of DNA topoisomerases involved in immediate and transient DNA relaxation induced by heat shock in Escherichia coli.
Molecular & general genetics : MGG 1994;244(5):451-5.
1994: Tohru Mizushima; A Tomura; T Shinpuku; T Miki; Kazuhisa Sekimizu
Loss of flagellation in dnaA mutants of Escherichia coli.
Journal of bacteriology 1994;176(17):5544-6.
1994: Tohru Mizushima; Y Ohtsuka; T Miki; Kazuhisa Sekimizu
Temperature shift-up leads to simultaneous and continuous plasmid DNA relaxation and induction of DnaK and GroEL proteins in anaerobically growing Escherichia coli cells.
FEMS microbiology letters 1994;121(3):333-6.