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Yoshiyuki Mizushina

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Kazuaki Shiomi; Hiromi Yoshida; Isoko Kuriyama; Yoshiyuki Mizushina
Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation.
Yoshiyuki Mizushina; Masayuki Nishida; Shin Nishiumi; Hiromi Yoshida; Takeshi Azuma; Masaru Yoshida
Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity (Review).
Hiroaki Akasaka; Ryohei Sasaki; Izumi Takayama; Toyofumi Yamaguchi; Hiromi Yoshida; Kenji Yoshida; Yoshiyuki Mizushina
Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells.

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2013: Kazuaki Shiomi; Hiromi Yoshida; Isoko Kuriyama; Yoshiyuki Mizushina
Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation.
Food chemistry 2013;139(1-4):910-8.
2013: Yoshiyuki Mizushina; Masayuki Nishida; Shin Nishiumi; Hiromi Yoshida; Takeshi Azuma; Masaru Yoshida
Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity (Review).
International journal of oncology 2013;42(3):793-802.
2013: Hiroaki Akasaka; Ryohei Sasaki; Izumi Takayama; Toyofumi Yamaguchi; Hiromi Yoshida; Kenji Yoshida; Yoshiyuki Mizushina
Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells.
Biochimica et biophysica acta 2013;1830(3):2517-25.
2013: Naoko Yoshida; Hiromi Yoshida; Isoko Kuriyama; Yoshiyuki Mizushina
Inhibitory effects of catechin derivatives on mammalian DNA polymerase and topoisomerase activities and mouse one-cell zygote development.
Journal of bioscience and bioengineering 2013;115(3):303-9.
2013: Isoko Kuriyama; Anna Miyazaki; Yuko Tsuda; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β.
Bioorganic & medicinal chemistry 2013;21(2):403-11.
2013: Hiromi Yoshida; Naoko Yoshida; Isoko Kuriyama; Yuka Tomiyama-Sakamoto; Yoshiyuki Mizushina
Profiles of lipid components, fatty acid distributions of triacylglycerols and phospholipids in Jack beans (Canavalia gladiata DC.).
Food chemistry 2013;136(2):807-12.
2012: Mai Mitoshi; Hironari Miyazato; Hiroto Nakayama; Keiichiro Sugimoto; Hiromi Yoshida; Tomoko Jippo; Kazuki Kanazawa; Yuko Kobayashi; Isoko Kuriyama; Yoshiyuki Mizushina
Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities.
Journal of agricultural and food chemistry 2012;60(45):11343-50.
2012: Yoshiyuki Mizushina; Fumio Sugawara; Toshifumi Takeuchi; Hiromi Yoshida
Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid.
Mini reviews in medicinal chemistry 2012;12(11):1135-43.
2012: Toshifumi Takeuchi; Satoshi Takaichi; Kenji Takemoto; Shogo Endo; Natsuki Inoue; Shinji Kamisuki; Yuri Katayama; Kouji Kuramochi; Yoshiyuki Mizushina; Yusuke Myobatake; Satomi Shimura; Fumio Sugawara
Total synthesis of (+)-Sch 725680: inhibitor of mammalian A-, B-, and Y-family DNA polymerases.
Organic letters 2012;14(17):4303-5.
2012: Yoshiyuki Mizushina; Takahiko Hada; Hiromi Yoshida
In vivo antitumor effect of liposomes with sialyl Lewis X including monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach.
Oncology reports 2012;28(3):821-8.
2012: Yuka Miyano; Yoshiyuki Mizushina; Atsuo Nakazaki; Keisuke Ohta; Mami Okado; Shinji Kamisuki; Susumu Kobayashi; Kouji Kuramochi; Tomoe Kusayanagi; Yuki Matsumoto; Masahiko Miura; Ippei Sakimoto; Satomi Shimura; Fumio Sugawara; Noriyuki Takahashi; Kaori Takakusagi; Yoichi Takakusagi; Ryo Takeuchi; Toshifumi Takeuchi; Senko Tsukuda; Kengo Sakaguchi
Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.
Bioorganic & medicinal chemistry 2012;20(13):3985-90.
2012: Yoshifumi Takao; Tasuku Yamada; Hiromi Yoshida; Isoko Kuriyama; Haruhiko Mizoguchi; Yoshiyuki Mizushina
Antifungal properties of Japanese cedar essential oil from waste wood chips made from used sake barrels.
Molecular medicine reports 2012;5(5):1163-8.
2012: Yusuke Myobatake; Fumio Sugawara; Toshifumi Takeuchi; Hiromi Yoshida; Ken Hirano; Tomomi Ishido; Kouji Kuramochi; Isoko Kuriyama; Yoshiyuki Mizushina
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
Journal of natural products 2012;75(2):135-41.
2012: Tsukasa Ishida; Yasuyuki Kondo; Ikuya Miki; Shigeto Mizuno; Yoshiyuki Mizushina; Shin Nishiumi; Saori Yagi; Hiromi Yoshida; Takeshi Azuma; Yasuhiro Irino; Masaru Yoshida
Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():650514.
2011: Aoganghua Aoganghua; Takeshi Azuma; Midori Hirai; Kazuki Kobayashi; Kouji Kuramochi; Yoshiyuki Mizushina; Masayuki Nishida; Shin Nishiumi; Shinwa Tanaka; Kazunori Tsubaki; Hiromi Yoshida; Masaru Yoshida
Inhibitory effects of vitamin K₃ derivatives on DNA polymerase and inflammatory activity.
International journal of molecular medicine 2011;28(6):937-45.
2011: Yoshiyuki Mizushina; Isoko Kuriyama; Naoki Maeda; Hiromi Yoshida
Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α.
Expert opinion on investigational drugs 2011;20(11):1523-34.
2011: Sayako Maruo; Kouji Kuramochi; Isoko Kuriyama; Kazunori Tsubaki; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.
Bioorganic & medicinal chemistry 2011;19(19):5803-12.
2011: Kouji Kuramochi; Yoshiyuki Mizushina; Kengo Sakaguchi; Fumio Sugawara; Takashi Sunoki; Kazunori Tsubaki; Masahiko Ikekita; Susumu Kobayashi
Transformation of thiols to disulfides by epolactaene and its derivatives.
Bioorganic & medicinal chemistry 2011;19(14):4162-72.
2011: Hiromi Yoshida; Naoko Yoshida; Isoko Kuriyama; Takaaki Tanigawa; Yuka Tomiyama; Yoshiyuki Mizushina
Variation in fatty acid distribution of different acyl lipids in rice (Oryza sativa L.) brans.
Nutrients 2011;3(4):505-14.
2011: Mi-Jin Yim; Masashi Hosokawa; Yoshiyuki Mizushina; Hiromi Yoshida; Yasunori Saito; Kazuo Miyashita
Suppressive effects of Amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression.
Journal of agricultural and food chemistry 2011;59(5):1646-52.
2011: Masaharu Takemura; Kurumi Sakuma; Tomoko Kazama; Yoshiyuki Mizushina; Teruyoshi Oshima
Growth inhibition and chromosomal instability of cultured marsupial (opossum) cells after treatment with DNA polymerase α inhibitor.
Bioscience, biotechnology, and biochemistry 2011;75(7):1349-53.
2011: Yoshiyuki Mizushina; Akiko Saito; Keiko Horikawa; Noriyuki Nakajima; Akira Tanaka; Hiromi Yoshida; Kiminori Matsubara
Acylated catechin derivatives: inhibitors of DNA polymerase and angiogenesis.
Frontiers in bioscience (Elite edition) 2011;3():1337-48.
2011: Yoshiyuki Mizushina; Jun Maeda; Yasuhiro Irino; Masayuki Nishida; Shin Nishiumi; Yasuyuki Kondo; Kazuyuki Nishio; Kouji Kuramochi; Kazunori Tsubaki; Isoko Kuriyama; Takeshi Azuma; Hiromi Yoshida; Masaru Yoshida
Effects of Intermediates between Vitamins K(2) and K(3) on Mammalian DNA Polymerase Inhibition and Anti-Inflammatory Activity.
International journal of molecular sciences 2011;12(2):1115-32.
2011: Kazuki Kobayashi; Shin Nishiumi; Masayuki Nishida; Midori Hirai; Takeshi Azuma; Hiromi Yoshida; Yoshiyuki Mizushina; Masaru Yoshida
Effects of quinone derivatives, such as 1,4-naphthoquinone, on DNA polymerase inhibition and anti-inflammatory action.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2011;7(1):37-44.
2011: Kanako Okusada; Kazuo Nakamoto; Mikako Nishida; Wakako Fujita-Hamabe; Kohei Kamiya; Yoshiyuki Mizushina; Toshiko Satake; Shogo Tokuyama
The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia.
Biological & pharmaceutical bulletin 2011;34(1):103-7.
2011: Naoki Maeda; K Matsubara; Hiromi Yoshida; Yoshiyuki Mizushina
Anti-cancer effect of spinach glycoglycerolipids as angiogenesis inhibitors based on the selective inhibition of DNA polymerase activity.
Mini reviews in medicinal chemistry 2011;11(1):32-8.
2010: Isoko Kuriyama; Anna Miyazaki; Yuko Tsuda; Toshio Yokoi; Yoshio Okada; Toshifumi Takeuchi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of somatostatin Peptide analogues on DNA polymerase activity and human cancer cell proliferation.
Anticancer research 2010;30(12):4841-9.
2010: Jun Maeda; Masayuki Nishida; Hirosato Takikawa; Hiromi Yoshida; Takeshi Azuma; Masaru Yoshida; Yoshiyuki Mizushina
Inhibitory effects of sulfobacin B on DNA polymerase and inflammation.
International journal of molecular medicine 2010;26(5):751-8.
2010: Yoshiyuki Mizushina; Jinhui Zhang; Angelo Pugliese; Sung-Hoon Kim; Junxuan Lü
Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases.
Biochemical pharmacology 2010;80(8):1125-32.
2010: Ken Hirano; Yuichiro Yoshida; Tomomi Ishido; Yukihisa Wada; Naoji Moriya; Naoshi Yamazaki; Yoshiyuki Mizushina; Yoshinobu Baba; Mitsuru Ishikawa
Consecutive incorporation of fluorophore-labeled nucleotides by mammalian DNA polymerase beta.
Analytical biochemistry 2010;405(2):160-7.
2010: Yoshiyuki Mizushina; Katsumi Nishimura; Yukiko Takenaka; Toshifumi Takeuchi; Fumio Sugawara; Hiromi Yoshida; Takao Tanahashi
Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth.
International journal of oncology 2010;37(4):993-1000.
2010: Shinichi Harada; Wakako Fujita-Hamabe; Kohei Kamiya; Yoshiyuki Mizushina; Toshiko Satake; Shogo Tokuyama
Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance.
Journal of natural medicines 2010;64(4):468-73.
2010: Tomoko Kayashima; Masaharu Mori; Ryo Mizutani; Kazuyuki Nishio; Kouji Kuramochi; Kazunori Tsubaki; Hiromi Yoshida; Yoshiyuki Mizushina; Kiminori Matsubara
Synthesis and biological evaluation of vitamin K derivatives as angiogenesis inhibitor.
Bioorganic & medicinal chemistry 2010;18(17):6305-9.
2010: Sho Horie; Chiaki Okuda; Takatoshi Yamashita; Kenichi Watanabe; Kouji Kuramochi; Masashi Hosokawa; Toshifumi Takeuchi; Makiko Kakuda; Kazuo Miyashita; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response.
Lipids 2010;45(8):713-21.
2010: Chisato Ishimaru; Toshifumi Takeuchi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effects of diacylglyceride phospholipids on DNA polymerase and topoisomerase activities, and human cancer cell growth.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2010;6(3):114-22.
2010: Masayuki Nishida; Shin Nishiumi; Yoshiyuki Mizushina; Yoshimi Fujishima; Koji Yamamoto; Atsuhiro Masuda; Shigeto Mizuno; Tsuyoshi Fujita; Yoshinori Morita; Hiromu Kutsumi; Hiromi Yoshida; Takeshi Azuma; Masaru Yoshida
Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-kappaB activation.
International journal of molecular medicine 2010;25(5):761-7.
2010: S Tanaka; Shin Nishiumi; M Nishida; Yoshiyuki Mizushina; Kazuyuki Kobayashi; A Masuda; Tsunenori Fujita; Yoshinori Morita; S Mizuno; H Kutsumi; Takeshi Azuma; M Yoshida
Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation.
Clinical and experimental immunology 2010;160(2):283-92.
2010: Yuko Kumamoto-Yonezawa; Ryohei Sasaki; Yoko Suzuki; Yuki Matsui; Takahiko Hada; Keisuke Uryu; Kazuro Sugimura; Hiromi Yoshida; Yoshiyuki Mizushina
Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor.
International journal of oncology 2010;36(3):577-84.
2010: Hiromi Yoshida; Naoko Yoshida; Kyoko Shibata; Yuka Tomiyama; Yoshiyuki Mizushina
Regiospecific profiles of fatty acids in triacylglycerols and phospholipids from Adzuki beans (Vigna angularis).
Nutrients 2010;2(1):49-59.
2010: Helfi Amalia; Ryohei Sasaki; Yoko Suzuki; Yusuke Demizu; Toshinori Bito; Hideki Nishimura; Yoshiaki Okamoto; Kenji Yoshida; Daisuke Miyawaki; Tetsuya Kawabe; Yoshiyuki Mizushina; Kazuro Sugimura
Vitamin K2-derived compounds induce growth inhibition in radioresistant cancer cells.
The Kobe journal of medical sciences 2010;56(2):E38-49.
2010: Sho Horie; Chiaki Okuda; Takatoshi Yamashita; Kenichi Watanabe; Yoshihiro Sato; Yasuhiro Yamaguchi; Toshifumi Takeuchi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
β-Sitosteryl (6'-O-linoleoyl)-glucoside of soybean (Glycine max L.) crude extract inhibits Y-family DNA polymerases.
Journal of oleo science 2010;59(11):621-30.
2010: Yasuhiro Yamaguchi; Daisuke Manita; Toshifumi Takeuchi; Kouji Kuramochi; Isoko Kuriyama; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases.
Bioscience, biotechnology, and biochemistry 2010;74(4):793-801.
2009: Kouji Kuramochi; Keishi Fukudome; Isoko Kuriyama; Toshifumi Takeuchi; Yoshihiro Sato; Shinji Kamisuki; Kazunori Tsubaki; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.
Bioorganic & medicinal chemistry 2009;17(20):7227-38.
2009: Yuki Matsui; Takahiko Hada; Naoki Maeda; Yoshihiro Sato; Yasuhiro Yamaguchi; Toshifumi Takeuchi; Masaharu Takemura; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Yoshiyuki Mizushina
Structure and activity relationship of monogalactosyl diacylglycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth.
Cancer letters 2009;283(1):101-7.
2009: Tomoko Kayashima; Masaharu Mori; Hiromi Yoshida; Yoshiyuki Mizushina; Kiminori Matsubara
1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis.
Cancer letters 2009;278(1):34-40.
2009: Yoshiyuki Mizushina
Specific inhibitors of mammalian DNA polymerase species.
Bioscience, biotechnology, and biochemistry 2009;73(6):1239-51.
2009: Katsumi Nishimura; Yukiko Takenaka; Manami Kishi; Takao Tanahashi; Hiromi Yoshida; Chiaki Okuda; Yoshiyuki Mizushina
Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds.
Chemical & pharmaceutical bulletin 2009;57(5):476-80.
2009: Yuko Kumamoto-Yonezawa; Ryohei Sasaki; Yosuke Ota; Yoko Suzuki; Shoji Fukushima; Takahiko Hada; Keisuke Uryu; Kazuro Sugimura; Hiromi Yoshida; Yoshiyuki Mizushina
Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression.
Biochimica et biophysica acta 2009;1790(5):339-46.
2009: Takuma Kimura; Toshifumi Takeuchi; Yuko Kumamoto-Yonezawa; Eiji Ohashi; Haruo Ohmori; Chikahide Masutani; Fumio Hanaoka; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases.
Bioorganic & medicinal chemistry 2009;17(5):1811-6.
2009: Yoshiyuki Mizushina; Hirohisa Motoshima; Yasuhiro Yamaguchi; Toshifumi Takeuchi; Ken Hirano; Fumio Sugawara; Hiromi Yoshida
3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain.
Marine drugs 2009;7(4):624-39.
2009: Yoshiyuki Mizushina; Daisuke Manita; Toshifumi Takeuchi; Fumio Sugawara; Yuko Kumamoto-Yonezawa; Yuki Matsui; Masaharu Takemura; Mitsuru Sasaki; Hiromi Yoshida; Hirosato Takikawa
The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta.
Molecules (Basel, Switzerland) 2009;14(1):102-21.
2008: Isoko Kuriyama; Keishi Fukudome; Shinji Kamisuki; Kouji Kuramochi; Kazunori Tsubaki; Kengo Sakaguchi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
The specific inhibitory effect of demethoxydehydroaltenusin, a derivative of dehydroaltenusin, on mammalian DNA polymerase alpha.
International journal of molecular medicine 2008;22(6):793-9.
2008: Hirosato Takikawa; Naoki Kamatani; Kohei Nakanishi; Takuya Tashiro; Mitsuru Sasaki; Hiromi Yoshida; Yoshiyuki Mizushina
Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A.
Bioscience, biotechnology, and biochemistry 2008;72(11):3071-4.
2008: Kiminori Matsubara; Tomoko Kayashima; Masaharu Mori; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis.
International journal of molecular medicine 2008;22(3):381-7.
2008: Naoki Maeda; Yasuo Kokai; Seiji Ohtani; Hiroeki Sahara; Yuko Kumamoto-Yonezawa; Isoko Kuriyama; Takahiko Hada; Noriyuki Sato; Hiromi Yoshida; Yoshiyuki Mizushina
Anti-tumor effect of orally administered spinach glycolipid fraction on implanted cancer cells, colon-26, in mice.
Lipids 2008;43(8):741-8.
2008: Yoshiyuki Mizushina; Toshifumi Takeuchi; Takahiko Hada; Naoki Maeda; Fumio Sugawara; Hiromi Yoshida; Masatoshi Fujita
The inhibitory action of SQDG (sulfoquinovosyl diacylglycerol) from spinach on Cdt1-geminin interaction.
Biochimie 2008;90(6):947-56.
2008: Kouji Kuramochi; Shunsuke Yukizawa; Seiki Ikeda; Takashi Sunoki; Satoshi Arai; Rie Matsui; Akinori Morita; Yoshiyuki Mizushina; Kengo Sakaguchi; Fumio Sugawara; Masahiko Ikekita; Susumu Kobayashi
Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation.
Bioorganic & medicinal chemistry 2008;16(9):5039-49.
2008: Masayuki Nishida; Noriko Ida; Mao Horio; Toshifumi Takeuchi; Shinji Kamisuki; Hiroshi Murata; Kouji Kuramochi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp.
Bioorganic & medicinal chemistry 2008;16(9):5115-22.
2008: Ryohei Sasaki; Yoko Suzuki; Yuko Yonezawa; Yosuke Ota; Yoshiaki Okamoto; Yusuke Demizu; Peng Huang; Hiromi Yoshida; Kazuro Sugimura; Yoshiyuki Mizushina
DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells.
Cancer science 2008;99(5):1040-8.
2008: Takuma Kimura; Masayuki Nishida; Kouji Kuramochi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases beta and lambda from Talaromyces sp.
Bioorganic & medicinal chemistry 2008;16(8):4594-9.
2008: Chisato Ishimaru; Yuko Yonezawa; Isoko Kuriyama; Masayuki Nishida; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth.
Lipids 2008;43(4):373-82.
2008: Mitsuki Naganuma; Masayuki Nishida; Kouji Kuramochi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae.
Bioorganic & medicinal chemistry 2008;16(6):2939-44.
2008: Yoshiyuki Mizushina; Toshifumi Takeuchi; Yoichi Takakusagi; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Masatoshi Fujita
Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction.
International journal of molecular medicine 2008;21(3):281-90.
2008: Shunya Takahashi; Yuko Yonezawa; Akemi Kubota; Narihito Ogawa; Katsuya Maeda; Hiroyuki Koshino; Tadashi Nakata; Hiromi Yoshida; Yoshiyuki Mizushina
Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth.
International journal of oncology 2008;32(2):451-8.
2008: Yoshiyuki Mizushina; Toshifumi Takeuchi; Yoichi Takakusagi; Yuko Yonezawa; Takeshi Mizuno; Ken-Ichiro Yanagi; Naoko Imamoto; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Masatoshi Fujita
Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction.
Biochimica et biophysica acta 2008;1780(2):203-13.
2008: Isoko Kuriyama; Takeshi Mizuno; Keishi Fukudome; Kouji Kuramochi; Kazunori Tsubaki; Takeo Usui; Naoko Imamoto; Kengo Sakaguchi; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells.
Molecules (Basel, Switzerland) 2008;13(12):2948-61.
2007: Ryoichi Nakamura; Ryo Takeuchi; Kouji Kuramochi; Yoshiyuki Mizushina; Chisato Ishimaru; Yoichi Takakusagi; Masaharu Takemura; Susumu Kobayashi; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi
Chemical properties of fatty acid derivatives as inhibitors of DNA polymerases.
Organic & biomolecular chemistry 2007;5(24):3912-21.
2007: Hiromi Yoshida; Yuka Tomiyama; Megumi Tanaka; Yoshiyuki Mizushina
Distribution of fatty acids in triacylglycerols and phospholipids from peas (Pisum sativum L.).
Journal of the science of food and agriculture 2007;87(14):2709-14.
2007: Yuko Yonezawa; Takahiko Hada; Keisuke Uryu; Tsuyoshi Tsuzuki; Kiyotaka Nakagawa; Teruo Miyazawa; Hiromi Yoshida; Yoshiyuki Mizushina
Mechanism of cell cycle arrest and apoptosis induction by conjugated eicosapentaenoic acid, which is a mammalian DNA polymerase and topoisomerase inhibitor.
International journal of oncology 2007;30(5):1197-204.
2007: Yoshiyuki Mizushina; Issei Dairaku; Noriyuki Yanaka; Toshifumi Takeuchi; Chisato Ishimaru; Fumio Sugawara; Hiromi Yoshida; Norihisa Kato
Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase.
Biochimie 2007;89(5):581-90.
2007: Shinji Kamisuki; Chisato Ishimaru; Kadohiro Onoda; Isoko Kuriyama; Noriko Ida; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp.
Bioorganic & medicinal chemistry 2007;15(9):3109-14.
2007: Kiminori Matsubara; Akiko Saito; Akira Tanaka; Noriyuki Nakajima; Reiko Akagi; Masaharu Mori; Yoshiyuki Mizushina
Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis.
Life sciences 2007;80(17):1578-85.
2007: Chisato Ishimaru; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Kengo Sakaguchi; Ikuo Kato; Hiromi Yoshida; Yoshiyuki Mizushina
Cholesterol hemisuccinate: a selective inhibitor of family X DNA polymerases.
Biochemical and biophysical research communications 2007;354(2):619-25.
2007: Naoki Maeda; Yasuo Kokai; Seiji Ohtani; Hiroeki Sahara; Isoko Kuriyama; Shinji Kamisuki; Shunya Takahashi; Kengo Sakaguchi; Fumio Sugawara; Hiromi Yoshida; Noriyuki Sato; Yoshiyuki Mizushina
Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha.
Biochemical and biophysical research communications 2007;352(2):390-6.
2007: Naoki Maeda; Yasuo Kokai; Seiji Ohtani; Hiroeki Sahara; Takahiko Hada; Chisato Ishimaru; Isoko Kuriyama; Yuko Yonezawa; Hiroshi Iijima; Hiromi Yoshida; Noriyuki Sato; Yoshiyuki Mizushina
Anti-tumor effects of the glycolipids fraction from spinach which inhibited DNA polymerase activity.
Nutrition and cancer 2007;57(2):216-23.
2007: Naoki Maeda; Takahiko Hada; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach.
Current medicinal chemistry 2007;14(9):955-67.
2007: Hiroshi Iijima; Nobuyuki Kasai; Hiroyuki Chiku; Toshifumi Takeuchi; Kouji Kuramochi; Shinya Hanashima; Susumu Kobayashi; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Yoshiyuki Mizushina
Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53.
International journal of molecular medicine 2007;19(1):41-8.
2006: Shizuka Murakami; Shinji Kamisuki; Kei-ichi Takata; Nobuyuki Kasai; Seisuke Kimura; Yoshiyuki Mizushina; Keisuke Ohta; Fumio Sugawara; Kengo Sakaguchi
Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta.
Biochemical and biophysical research communications 2006;350(1):7-16.
2006: Yuko Yonezawa; Takahiko Hada; Keisuke Uryu; Hiroshi Iijima; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases.
International journal of molecular medicine 2006;18(4):583-8.
2006: Yuko Yonezawa; Isoko Kuriyama; Atsushi Fukuoh; Tatsushi Muta; Dongchon Kang; Masaharu Takemura; Ikuo Kato; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line.
Cancer science 2006;97(8):716-23.
2006: Hiroshi Iijima; Nobuyuki Kasai; Hiroyuki Chiku; Shizuka Murakami; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Yoshiyuki Mizushina
The inhibitory action of long-chain fatty acids on the DNA binding activity of p53.
Lipids 2006;41(6):521-7.
2006: Yoshiyuki Mizushina; Rumi Nakanishi; Isoko Kuriyama; Kohei Kamiya; Toshiko Satake; Noriko Shimazaki; Osamu Koiwai; Yukinobu Uchiyama; Yuko Yonezawa; Masaharu Takemura; Kengo Sakaguchi; Hiromi Yoshida
Beta-sitosterol-3-O-beta-D-glucopyranoside: a eukaryotic DNA polymerase lambda inhibitor.
The Journal of steroid biochemistry and molecular biology 2006;99(2-3):100-7.
2006: Kouji Kuramochi; Rie Matsui; Yasuaki Matsubara; Junko Nakai; Takashi Sunoki; Satoshi Arai; Seigo Nagata; Yukitoshi Nagahara; Yoshiyuki Mizushina; Masahiko Ikekita; Susumu Kobayashi
Apoptosis-inducing effect of epolactaene derivatives on BALL-1 cells.
Bioorganic & medicinal chemistry 2006;14(7):2151-61.
2006: Hiroshi Iijima; Keiichi Musumi; Takahiko Hada; Naoki Maeda; Yuko Yonezawa; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of monogalactosyldiacylglycerol, extracted from spinach using supercritical CO2, on mammalian DNA polymerase activity.
Journal of agricultural and food chemistry 2006;54(5):1627-32.
2006: Toshifumi Takeuchi; Tomomi Ishidoh; Hiroshi Iijima; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Kouji Kuramochi; Susumu Kobayashi; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Yoshiyuki Mizushina
Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(3):223-35.
2006: Kiminori Matsubara; Akiko Saito; Akira Tanaka; Noriyuki Nakajima; Reiko Akagi; Masaharu Mori; Yoshiyuki Mizushina
Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis.
DNA and cell biology 2006;25(2):95-103.
2006: Yoshiyuki Mizushina; Etsuko Yagita; Kouji Kuramochi; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Yukinobu Uchiyama; Yuko Yomezawa; Fumio Sugawara; Susumu Kobayashi; Kengo Sakaguchi; Hiromi Yoshida
5-(Hydroxymethyl)-2-furfural: a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase.
Archives of biochemistry and biophysics 2006;446(1):69-76.
2006: Yoshiyuki Mizushina; Kiyotaka Nakagawa; Akira Shibata; Yasutoshi Awata; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Yukinobu Uchiyama; Kengo Sakaguchi; Teruo Miyazawa; Hiromi Yoshida
Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
Biochemical and biophysical research communications 2006;339(3):949-55.
2006: TOMOYUKI FURUKAWA; Masayuki Nishida; Takahiko Hada; Kouji Kuramochi; Fumio Sugawara; Susumu Kobayashi; Hiroshi Iijima; Hiroaki Shimada; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic DNA polymerase I activity and cell growth of Escherichia coli.
Journal of oleo science 2006;56(1):43-7.
2005: Yoshiyuki Mizushina; Tomomi Ishidoh; Toshifumi Takeuchi; Noriko Shimazaki; Osamu Koiwai; Kouji Kuramochi; Susumu Kobayashi; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida
Monoacetylcurcumin: a new inhibitor of eukaryotic DNA polymerase lambda and a new ligand for inhibitor-affinity chromatography.
Biochemical and biophysical research communications 2005;337(4):1288-95.
2005: Yoshiyuki Mizushina; Nobuyuki Kasai; Hiroshi Iijima; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi
Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent.
Current medicinal chemistry. Anti-cancer agents 2005;5(6):613-25.
2005: Ikuo Kato; Isoko Kuriyama; Naoki Asano; Kyoko Ikeda; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of dipeptide alcohol derivatives containing mercapto group on eukaryotic DNA polymerase alpha.
International journal of molecular medicine 2005;16(4):653-9.
2005: Isoko Kuriyama; Keiichi Musumi; Yuko Yonezawa; Masaharu Takemura; Naoki Maeda; Hiroshi Iijima; Takahiko Hada; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation.
The Journal of nutritional biochemistry 2005;16(10):594-601.
2005: Yoshiyuki Mizushina; Toshihiro Akihisa; Motohiko Ukiya; Yusuke Hamasaki; Chikako Murakami-Nakai; Isoko Kuriyama; Toshifumi Takeuchi; Fumio Sugawara; Hiromi Yoshida
Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors.
Life sciences 2005;77(17):2127-40.
2005: Nobuyuki Kasai; Yoshiyuki Mizushina; Hiroshi Murata; Takayuki Yamazaki; Tadayasu Ohkubo; Kengo Sakaguchi; Fumio Sugawara
Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase beta.
The FEBS journal 2005;272(17):4349-61.
2005: Yoshiyuki Mizushina; Hirosato Takikawa; Yusuke Imamura; Mitsuru Sasaki; Kenji Mori; Hiromi Yoshida
Inhibitory effect of mispyric acid on mammalian DNA polymerases.
Bioscience, biotechnology, and biochemistry 2005;69(8):1534-8.
2005: Yuko Yonezawa; Takahiko Hada; Keisuke Uryu; Tsuyoshi Tsuzuki; Takahiro Eitsuka; Teruo Miyazawa; Chikako Murakami-Nakai; Hiromi Yoshida; Yoshiyuki Mizushina
Inhibitory effect of conjugated eicosapentaenoic acid on mammalian DNA polymerase and topoisomerase activities and human cancer cell proliferation.
Biochemical pharmacology 2005;70(3):453-60.
2005: Yoshiyuki Mizushina; Akiko Saito; Akira Tanaka; Noriyuki Nakajima; Isoko Kuriyama; Masaharu Takemura; Toshifumi Takeuchi; Fumio Sugawara; Hiromi Yoshida
Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors.
Biochemical and biophysical research communications 2005;333(1):101-9.
2005: Kiminori Matsubara; Hiroaki Matsumoto; Yoshiyuki Mizushina; Masaharu Mori; Nobuyoshi Nakajima; Michiko Fuchigami; Hiromi Yoshida; Takahiko Hada
Inhibitory effect of glycolipids from spinach on in vitro and ex vivo angiogenesis.
Oncology reports 2005;14(1):157-60.
2005: Atsuko Itoh; Tomoko Kumashiro; Machiko Yamaguchi; Naotaka Nagakura; Yoshiyuki Mizushina; Toyoyuki Nishi; Takao Tanahashi
Indole alkaloids and other constituents of Rauwolfia serpentina.
Journal of natural products 2005;68(6):848-52.
2005: Yoshiyuki Mizushina; Kouji Kuramochi; Hiroshi Ikawa; Isoko Kuriyama; Noriko Shimazaki; Masaharu Takemura; Masahiko Oshige; Hiromi Yoshida; Osamu Koiwai; Fumio Sugawara; Susumu Kobayashi; Kengo Sakaguchi
Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds.
International journal of molecular medicine 2005;15(5):785-93.
2005: Akiko Saito; Yoshiyuki Mizushina; Hiroshi Ikawa; Hiromi Yoshida; Yuki Doi; Akira Tanaka; Noriyuki Nakajima
Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases.
Bioorganic & medicinal chemistry 2005;13(8):2759-71.
2005: Isoko Kuriyama; Naoki Asano; Ikuo Kato; Kyoko Ikeda; Masaharu Takemura; Hiromi Yoshida; Kengo Sakaguchi; Yoshiyuki Mizushina
Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase alpha.
Bioorganic & medicinal chemistry 2005;13(6):2187-96.
2005: Yuko Yonezawa; Tsuyoshi Tsuzuki; Takahiro Eitsuka; Teruo Miyazawa; Takahiko Hada; Keisuke Uryu; Chikako Murakami-Nakai; Hiroshi Ikawa; Isoko Kuriyama; Masaharu Takemura; Masahiko Oshige; Hiromi Yoshida; Kengo Sakaguchi; Yoshiyuki Mizushina
Inhibitory effect of conjugated eicosapentaenoic acid on human DNA topoisomerases I and II.
Archives of biochemistry and biophysics 2005;435(1):197-206.
2005: Naoki Maeda; Takahiko Hada; Chikako Murakami-Nakai; Isoko Kuriyama; Hideki Ichikawa; Yoshinobu Fukumori; Junichi Hiratsuka; Hiromi Yoshida; Kengo Sakaguchi; Yoshiyuki Mizushina
Effects of DNA polymerase inhibitory and antitumor activities of lipase-hydrolyzed glycolipid fractions from spinach.
The Journal of nutritional biochemistry 2005;16(2):121-8.
2004: Shinji Kamisuki; Shunya Takahashi; Yoshiyuki Mizushina; Kengo Sakaguchi; Tadashi Nakata; Fumio Sugawara
Precise structural elucidation of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha.
Bioorganic & medicinal chemistry 2004;12(20):5355-9.
2004: Yoshiyuki Mizushina; Tsuyoshi Tsuzuki; Takahiro Eitsuka; Teruo Miyazawa; Kanako Kobayashi; Hiroshi Ikawa; Isoko Kuriyama; Yuko Yonezawa; Masaharu Takemura; Hiromi Yoshida; Kengo Sakaguchi
Inhibitory action of conjugated C18-fatty acids on DNA polymerases and DNA topoisomerases.
Lipids 2004;39(10):977-83.
2004: Chikako Murakami-Nakai; Naoki Maeda; Yuko Yonezawa; Isoko Kuriyama; Shinji Kamisuki; Shunya Takahashi; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi; Yoshiyuki Mizushina
The effects of dehydroaltenusin, a novel mammalian DNA polymerase alpha inhibitor, on cell proliferation and cell cycle progression.
Biochimica et biophysica acta 2004;1674(2):193-9.
2004: Tetsuhiro Tsuruma; Hiroeki Sahara; Mika Takenouchi; Atsuhito Yagihashi; Yuji Iwayama; Hiroaki Shima; Tomohisa Furuhata; Toshihiko Torigoe; Shinya Hanashima; Takayuki Yamazaki; Fumio Sugawara; Yoshiyuki Mizushina; Keisuke Ohta; Kengo Sakaguchi; Noriyuki Sato; Koichi Hirata
Synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats.
Transplantation proceedings 2004;36(7):1965-9.
2004: Yoshiyuki Mizushina; Nobuyuki Kasai; Katsumi Miura; Shinya Hanashima; Masaharu Takemura; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi
Structural relationship of lithocholic acid derivatives binding to the N-terminal 8-kDa domain of DNA polymerase beta.
Biochemistry 2004;43(33):10669-77.
2004: Akitsu Ogawa; Chikako Murakami; Shinji Kamisuki; Isoko Kuriyama; Hiromi Yoshida; Fumio Sugawara; Yoshiyuki Mizushina
Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin.
Bioorganic & medicinal chemistry letters 2004;14(13):3539-43.
2004: Kouji Kuramochi; Yoshiyuki Mizushina; Seigo Nagata; Fumio Sugawara; Kengo Sakaguchi; Susumu Kobayashi
Structure-activity relationships of epolactaene analogs as DNA polymerases inhibitors.
Bioorganic & medicinal chemistry 2004;12(9):1983-9.
2004: Yoshiyuki Mizushina; Toshihiro Akihisa; Motohiko Ukiya; Chikako Murakami; Isoko Kuriyama; Xianai Xu; Hiromi Yoshida; Kengo Sakaguchi
A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos.
Cancer science 2004;95(4):354-60.
2004: Chikako Murakami; Takeshi Miuzno; Fumio Hanaoka; Hiromi Yoshida; Kengo Sakaguchi; Yoshiyuki Mizushina
Mechanism of cell cycle arrest by sulfoquinovosyl monoacylglycerol with a C18-saturated fatty acid (C18-SQMG).
Biochemical pharmacology 2004;67(7):1373-80.
2004: Isoko Kuriyama; Naoki Asano; Ikuo Kato; Masahiko Oshige; Akio Sugino; Yasuhiro Kadota; Kazuyuki Kuchitsu; Hiromi Yoshida; Kengo Sakaguchi; Yoshiyuki Mizushina
L-Homoserylaminoethanol, a novel dipeptide alcohol inhibitor of eukaryotic DNA polymerase from a plant cultured cells, Nicotina tabacum L.
Bioorganic & medicinal chemistry 2004;12(5):957-62.
2004: Toshihiro Akihisa; Yoshiyuki Mizushina; Motohiko Ukiya; Manabu Oshikubo; Seizo Kondo; Yumiko Kimura; Takashi Suzuki; Takaaki Tai
Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta.
Bioscience, biotechnology, and biochemistry 2004;68(2):448-50.
2004: Kiminori Matsubara; Masaharu Mori; Yoshiyuki Mizushina
Petasiphenol which inhibits DNA polymerase lambda activity is an inhibitor of in vitro angiogenesis.
Oncology reports 2004;11(2):447-51.
2003: Yoshiyuki Mizushina; Xianai Xu; Kiminori Matsubara; Chikako Murakami; Isoko Kuriyama; Masahiko Oshige; Masaharu Takemura; Norihisa Kato; Hiromi Yoshida; Kengo Sakaguchi
Pyridoxal 5'-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon.
Biochemical and biophysical research communications 2003;312(4):1025-32.
2003: Yoshiyuki Mizushina; Mitsuru Hirota; Chikako Murakami; Tomomi Ishidoh; Shinji Kamisuki; Noriko Shimazaki; Masaharu Takemura; Marinela Perpelescu; Motoshi Suzuki; Hiromi Yoshida; Fumio Sugawara; Osamu Koiwai; Kengo Sakaguchi
Some anti-chronic inflammatory compounds are DNA polymerase lambda-specific inhibitors.
Biochemical pharmacology 2003;66(10):1935-44.
2003: Yoshiyuki Mizushina; Naoki Maeda; Miho Kawasaki; Hideki Ichikawa; Chikako Murakami; Masaharu Takemura; Xianai Xu; Fumio Sugawara; Yoshinobu Fukumori; Hiromi Yoshida; Kengo Sakaguchi
Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases.
Lipids 2003;38(10):1065-74.
2003: Chikako Murakami; Masaharu Takemura; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Yoshiyuki Mizushina
Analysis of cell cycle regulation by 1-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride (SQMG), an inhibitor of eukaryotic DNA polymerases.
Biochemical pharmacology 2003;66(4):541-50.
2003: Yoshiyuki Mizushina; Xianai Xu; Chikako Murakami; Toshio Okano; Masaharu Takemura; Hiromi Yoshida; Kengo Sakaguchi
Selective inhibition of mammalian DNA polymerase alpha by vitamin D2 and D3.
Journal of pharmacological sciences 2003;92(3):283-90.
2003: Kiminori Matsubara; Hiroaki Matsumoto; Yoshiyuki Mizushina; Jung Sup Lee; Norihisa Kato
Inhibitory effect of pyridoxal 5'-phosphate on endothelial cell proliferation, replicative DNA polymerase and DNA topoisomerase.
International journal of molecular medicine 2003;12(1):51-5.
2003: Yoshiyuki Mizushina; Chikako Murakami; Kentaro Yogi; Katsuhiro Ueda; Tomomi Ishidoh; Masaharu Takemura; Marinela Perpelescu; Motoshi Suzuki; Masahiko Oshige; Toyofumi Yamaguchi; Mineo Saneyoshi; Hiromi Yoshida; Kengo Sakaguchi
Kohamaic acid A, a novel sesterterpenic acid, inhibits activities of DNA polymerases from deuterostomes.
Biochimica et biophysica acta 2003;1648(1-2):55-61.
2003: Yoshiyuki Mizushina; Akira Ikuta; Kenji Endoh; Masahiko Oshige; Nobuyuki Kasai; Kohei Kamiya; Toshiko Satake; Hiroshi Takazawa; Hiromasa Morita; Hiroaki Tomiyasu; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi
Inhibition of DNA polymerases and DNA topoisomerase II by triterpenes produced by plant callus.
Biochemical and biophysical research communications 2003;305(2):365-73.
2003: Yoshiyuki Mizushina; Xianai Xu; Naoki Asano; Nobuyuki Kasai; Atsushi Kato; Masaharu Takemura; Hitomi Asahara; Stuart Linn; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi
The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-D-ribitol, on eukaryotic DNA polymerases.
Biochemical and biophysical research communications 2003;304(1):78-85.
2003: Yoshiyuki Mizushina; Chikako Murakami; Hirosato Takikawa; Nobuyuki Kasai; Xianai Xu; Kenji Mori; Masahiko Oshige; Toyofumi Yamaguchi; Mineo Saneyoshi; Noriko Shimazaki; Osamu Koiwai; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi
Molecular action mode of Hippospongic acid A, an inhibitor of gastrulation of starfish embryos.
Journal of biochemistry 2003;133(4):541-52.
2003: Yoshiyuki Mizushina; Xianai Xu; Hitomi Asahara; Ryo Takeuchi; Masahiko Oshige; Noriko Shimazaki; Masaharu Takemura; Toyofumi Yamaguchi; Kazufumi Kuroda; Stuart Linn; Hiromi Yoshida; Osamu Koiwai; Mineo Saneyoshi; Fumio Sugawara; Kengo Sakaguchi
A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor.
The Biochemical journal 2003;370(Pt 1):299-305.
2003: Yoshiyuki Mizushina; Tomomi Ishidoh; Shinji Kamisuki; Satoshi Nakazawa; Masaharu Takemura; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi
Flavonoid glycoside: a new inhibitor of eukaryotic DNA polymerase alpha and a new carrier for inhibitor-affinity chromatography.
Biochemical and biophysical research communications 2003;301(2):480-7.
2003: Chikako Murakami; Takayuki Yamazaki; Shinya Hanashima; Shunya Takahashi; Masaharu Takemura; Shonen Yoshida; Keisuke Ohta; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Yoshiyuki Mizushina
A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid.
Biochimica et biophysica acta 2003;1645(1):72-80.
2003: Chikako Murakami; Taeko Kumagai; Takahiko Hada; Ui Kanekazu; Satoshi Nakazawa; Shinji Kamisuki; Naoki Maeda; Xianai Xu; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Yoshiyuki Mizushina
Effects of glycolipids from spinach on mammalian DNA polymerases.
Biochemical pharmacology 2003;65(2):259-67.
2002: Yoshiyuki Mizushina; Shinji Kamisuki; Nobuyuki Kasai; Tomomi Ishidoh; Noriko Shimazaki; Masaharu Takemura; Hitomi Asahara; Stuart Linn; Shonen Yoshida; Osamu Koiwai; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi
Petasiphenol: a DNA polymerase lambda inhibitor.
Biochemistry 2002;41(49):14463-71.
2002: Nobuyuki Kasai; Yoshiyuki Mizushina; Fumio Sugawara; Kengo Sakaguchi
Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase.
Journal of biochemistry 2002;132(5):819-28.
2002: Masako Oda; Takamasa Ueno; Nobuyuki Kasai; Hirotada Takahashi; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Hideya Hayashi; Yoshiyuki Mizushina
Inhibition of telomerase by linear-chain fatty acids: a structural analysis.
The Biochemical journal 2002;367(Pt 2):329-34.
2002: Yoshitaka Matsumoto; Hiroeki Sahara; Tatsuya Fujita; Kumiko Shimozawa; Mika Takenouchi; Toshihiko Torigoe; Shinya Hanashima; Takeyuki Yamazaki; Shunya Takahashi; Fumio Sugawara; Yoshiyuki Mizushina; Keisuke Ohta; Nobuaki Takahashi; Shinsei Gasa; Kowichi Jimbow; Kengo Sakaguchi; Noriyuki Sato
An immunosuppressive effect by synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin.
Transplantation 2002;74(2):261-7.
2002: Chikako Murakami; Takayuki Yamazaki; Shinya Hanashima; Shunya Takahashi; Keisuke Ohta; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Yoshiyuki Mizushina
Structure-function relationship of synthetic sulfoquinovosyl-acylglycerols as mammalian DNA polymerase inhibitors.
Archives of biochemistry and biophysics 2002;403(2):229-36.
2002: Yoshiyuki Mizushina; Nobuyuki Kasai; Fumio Sugawara; Kengo Sakaguchi
[Structural homology between molecular probes binding site of DNA polymerase beta and DNA topoisomerase II].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(6):708-14.
2002: Chikako Murakami; Kiyomi Ishijima; Mitsuru Hirota; Kengo Sakaguchi; Hiromi Yoshida; Yoshiyuki Mizushina
Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases.
Biochimica et biophysica acta 2002;1596(2):193-200.
2002: Kengo Sakaguchi; Fumio Sugawara; Yoshiyuki Mizushina
[Inhibitors of eukaryotic DNA polymerases].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(3):244-51.
2002: Chikako Murakami; Masaharu Takemura; Yuichi Sugiyama; Shinji Kamisuki; Hitomi Asahara; Miho Kawasaki; Tomomi Ishidoh; Stuart Linn; Shonen Yoshida; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi; Yoshiyuki Mizushina
Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases.
Biochimica et biophysica acta 2002;1574(1):85-92.
2002: Madoka Watanabe; Shinya Hanashima; Yoshiyuki Mizushina; Hiromi Yoshida; Masahiko Oshige; Kengo Sakaguchi; Fumio Sugawara
Biotinylated lithocholic acids for affinity chromatography of mammalian DNA polymerases alpha and beta.
Bioorganic & medicinal chemistry letters 2002;12(3):287-90.
2002: Shinji Kamisuki; Chikako Murakami; Keisuke Ohta; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Yoshiyuki Mizushina
Actions of derivatives of dehydroaltenusin, a new mammalian DNA polymerase alpha-specific inhibitor.
Biochemical pharmacology 2002;63(3):421-7.
2002: Yoshiyuki Mizushina; Chikako Murakami; Keisuke Ohta; Hirosato Takikawa; Kenji Mori; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi
Selective inhibition of the activities of both eukaryotic DNA polymerases and DNA topoisomerases by elenic acid.
Biochemical pharmacology 2002;63(3):399-407.
2002: Yoshiyuki Mizushina; Shinji Kamisuki; Nobuyuki Kasai; Noriko Shimazaki; Masaharu Takemura; Hitomi Asahara; Stuart Linn; Shonen Yoshida; Akio Matsukage; Osamu Koiwai; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi
A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda.
The Journal of biological chemistry 2002;277(1):630-8.
2002: Hiroeki Sahara; Shinya Hanashima; Takayuki Yamazaki; Shunya Takahashi; Fumio Sugawara; Seiji Ohtani; Masako Ishikawa; Yoshiyuki Mizushina; Keisuke Ohta; Kumiko Shimozawa; Shinsei Gasa; Kowichi Jimbow; Kengo Sakaguchi; Noriyuki Sato; Nobuaki Takahashi
Anti-tumor effect of chemically synthesized sulfolipids based on sea urchin's natural sulfonoquinovosylmonoacylglycerols.
Japanese journal of cancer research : Gann 2002;93(1):85-92.
2001: Keisuke Ohta; Yoshiyuki Mizushina; T Yamazaki; S Hanashima; Fumio Sugawara; Kengo Sakaguchi
Specific interaction between an oligosaccharide on the tumor cell surface and the novel antitumor agents, sulfoquinovosylacylglycerols.
Biochemical and biophysical research communications 2001;288(4):893-900.
2001: Yoshiyuki Mizushina; Nobuyuki Kasai; Fumio Sugawara; A Iida; Hiromi Yoshida; Kengo Sakaguchi
Three-dimensional structural model analysis of the binding site of lithocholic acid, an inhibitor of DNA polymerase beta and DNA topoisomerase II.
Journal of biochemistry 2001;130(5):657-64.
2001: Yoshiyuki Mizushina; Y Sugiyama; H Yoshida; S Hanashima; T Yamazaki; Shinji Kamisuki; Keisuke Ohta; M Takemura; T Yamaguchi; Akio Matsukage; S Yoshida; Mineo Saneyoshi; Fumio Sugawara; K Sakagauchi
Galactosyldiacylglycerol, a mammalian DNA polymerase alpha-specific inhibitor from a sea alga, Petalonia bingbamiae.
Biological & pharmaceutical bulletin 2001;24(9):982-7.
2001: Shinya Hanashima; Yoshiyuki Mizushina; Takayuki Yamazaki; Keisuke Ohta; Shunya Takahashi; Hiroeki Sahara; Kengo Sakaguchi; F Sugawar
Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta.
Bioorganic & medicinal chemistry 2001;9(2):367-76.
2000: Yoshiyuki Mizushina; Fumio Sugawara; A Iida; Kengo Sakaguchi
Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II.
Journal of molecular biology 2000;304(3):385-95.
2000: Yoshitaka Matsumoto; Hiroeki Sahara; Tatsuya Fujita; Shinya Hanashima; Takayuki Yamazaki; Shunya Takahashi; Fumio Sugawara; Yoshiyuki Mizushina; Keisuke Ohta; Nobuaki Takahashi; Kowichi Jimbow; Kengo Sakaguchi; Noriyuki Sato
A novel immunosuppressive agent, SQDG, derived from sea urchin.
Transplantation proceedings 2000;32(7):2051-3.
2000: Yoshiyuki Mizushina; Shinji Kamisuki; T Mizuno; Masaharu Takemura; Hitomi Asahara; Stuart Linn; T Yamaguchi; Akio Matsukage; F Hanaoka; Shonen Yoshida; Mineo Saneyoshi; Fumio Sugawara; Kengo Sakaguchi
Dehydroaltenusin, a mammalian DNA polymerase alpha inhibitor.
The Journal of biological chemistry 2000;275(43):33957-61.
2000: Yoshiyuki Mizushina; T Ueno; M Oda; T Yamaguchi; Mineo Saneyoshi; Kengo Sakaguchi
The biochemical mode of inhibition of DNA polymerase beta by alpha-rubromycin.
Biochimica et biophysica acta 2000;1523(2-3):172-81.
2000: Yoshiyuki Mizushina; T Ohkubo; Fumio Sugawara; Kengo Sakaguchi
Structure of lithocholic acid binding to the N-terminal 8-kDa domain of DNA polymerase beta.
Biochemistry 2000;39(41):12606-13.
2000: S Hanashima; Yoshiyuki Mizushina; Keisuke Ohta; T Yamazaki; Fumio Sugawara; Kengo Sakaguchi
Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols.
Japanese journal of cancer research : Gann 2000;91(10):1073-83.
2000: Yoshiyuki Mizushina; A Iida; Keisuke Ohta; Fumio Sugawara; Kengo Sakaguchi
Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase.
The Biochemical journal 2000;350 Pt 3():757-63.
2000: Yoshiyuki Mizushina; M Sagisaka; H Sakaib; M Abeb; Kengo Sakaguchi
Mode analysis of binding of fatty acids to mammalian DNA polymerases.
Biochimica et biophysica acta 2000;1486(2-3):211-8.
2000: Yoshiyuki Mizushina; Susumu Kobayashi; Kouji Kuramochi; S Nagata; Fumio Sugawara; Kengo Sakaguchi
Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II.
Biochemical and biophysical research communications 2000;273(2):784-8.
2000: Yoshiyuki Mizushina; S Miyazaki; Keisuke Ohta; M Hirota; Kengo Sakaguchi
Novel anti-inflammatory compounds from Myrsine seguinii, terpeno-benzoic acids, are inhibitors of mammalian DNA polymerases.
Biochimica et biophysica acta 2000;1475(1):1-4.
2000: Keisuke Ohta; S Hanashima; Yoshiyuki Mizushina; T Yamazaki; Mineo Saneyoshi; Fumio Sugawara; Kengo Sakaguchi
Studies on a novel DNA polymerase inhibitor group, synthetic sulfoquinovosylacylglycerols: inhibitory action on cell proliferation.
Mutation research 2000;467(2):139-52.
1999: Yoshiyuki Mizushina; T Ohkubo; T Date; T Yamaguchi; Mineo Saneyoshi; Fumio Sugawara; Kengo Sakaguchi
Mode analysis of a fatty acid molecule binding to the N-terminal 8-kDa domain of DNA polymerase beta. A 1:1 complex and binding surface.
The Journal of biological chemistry 1999;274(36):25599-607.
1999: Yoshiyuki Mizushina; N Takahashi; L Hanashima; Hiroyuki Koshino; Yasuaki Esumi; Jun Uzawa; Fumio Sugawara; Kengo Sakaguchi
Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum.
Bioorganic & medicinal chemistry 1999;7(9):2047-52.
1999: Yoshiyuki Mizushina; N Takahashi; A Ogawa; K Tsurugaya; Hiroyuki Koshino; Masaharu Takemura; Shonen Yoshida; Akio Matsukage; Fumio Sugawara; Kengo Sakaguchi
The cyanogenic glucoside, prunasin (D-mandelonitrile-beta-D-glucoside), is a novel inhibitor of DNA polymerase beta.
Journal of biochemistry 1999;126(2):430-6.
1999: Keisuke Ohta; Yoshiyuki Mizushina; N Hirata; Masaharu Takemura; Fumio Sugawara; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
Action of a new mammalian DNA polymerase inhibitor, sulfoquinovosyldiacylglycerol.
Biological & pharmaceutical bulletin 1999;22(2):111-6.
1998: Yoshiyuki Mizushina; T Ueno; Y Goto; Y Isobe; M Sako; T Fujita; K Hirota; H Hayashi; Kengo Sakaguchi
Carboxyflavins, novel inhibitors of Taq DNA polymerase.
International journal of molecular medicine 1998;2(3):283-6.
1998: H Togashi; Yoshiyuki Mizushina; Masaharu Takemura; Fumio Sugawara; Hiroyuki Koshino; Yasuaki Esumi; Jun Uzawa; H Kumagai; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
4-Hydroxy-17-methylincisterol, an inhibitor of DNA polymerase-alpha activity and the growth of human cancer cells in vitro.
Biochemical pharmacology 1998;56(5):583-90.
1998: Yoshiyuki Mizushina; L Hanashima; T Yamaguchi; Masaharu Takemura; Fumio Sugawara; Mineo Saneyoshi; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases.
Biochemical and biophysical research communications 1998;249(1):17-22.
1998: H Seto; M Hatanaka; Seisuke Kimura; Masahiko Oshige; Y Tsuya; Yoshiyuki Mizushina; Tomoyuki Sawado; N Aoyagi; T Matsumoto; J Hashimoto; Kengo Sakaguchi
Purification and characterization of a 100 kDa DNA polymerase from cauliflower inflorescence.
The Biochemical journal 1998;332 ( Pt 2)():557-63.
1998: Yoshiyuki Mizushina; Akio Matsukage; Kengo Sakaguchi
The biochemical inhibition mode of bredinin-5'-monophosphate on DNA polymerase beta.
Biochimica et biophysica acta 1998;1403(1):5-11.
1998: Yoshiyuki Mizushina; I Watanabe; H Togashi; L Hanashima; Masaharu Takemura; Keisuke Ohta; Fumio Sugawara; Hiroyuki Koshino; Yasuaki Esumi; Jun Uzawa; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta.
Biological & pharmaceutical bulletin 1998;21(5):444-8.
1998: Keisuke Ohta; Yoshiyuki Mizushina; N Hirata; Masaharu Takemura; Fumio Sugawara; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella.
Chemical & pharmaceutical bulletin 1998;46(4):684-6.
1998: Yoshiyuki Mizushina; N Tanaka; A Kitamura; K Tamai; M Ikeda; Masaharu Takemura; Fumio Sugawara; T Arai; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
The inhibitory effect of novel triterpenoid compounds, fomitellic acids, on DNA polymerase beta.
The Biochemical journal 1998;330 ( Pt 3)():1325-32.
1998: Yoshiyuki Mizushina; I Watanabe; Keisuke Ohta; Masaharu Takemura; Hiroeki Sahara; N Takahashi; Shinsei Gasa; Fumio Sugawara; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
Studies on inhibitors of mammalian DNA polymerase alpha and beta: sulfolipids from a pteridophyte, Athyrium niponicum.
Biochemical pharmacology 1998;55(4):537-41.
1998: N Tanaka; A Kitamura; Yoshiyuki Mizushina; Fumio Sugawara; Kengo Sakaguchi
Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea.
Journal of natural products 1998;61(2):193-7.
1998: T Horie; Yoshiyuki Mizushina; Masaharu Takemura; Fumio Sugawara; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
A 5'-monophosphate form of bredinin selectively inhibits the activities of mammalian DNA polymerases in vitro.
International journal of molecular medicine 1998;1(1):83-90.
1997: Yoshiyuki Mizushina; Shonen Yoshida; Akio Matsukage; Kengo Sakaguchi
The inhibitory action of fatty acids on DNA polymerase beta.
Biochimica et biophysica acta 1997;1336(3):509-21.
1996: Yoshiyuki Mizushina; N Tanaka; H Yagi; T Kurosawa; M Onoue; H Seto; T Horie; N Aoyagi; M Yamaoka; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro.
Biochimica et biophysica acta 1996;1308(3):256-62.
1996: Yoshiyuki Mizushina; H Yagi; N Tanaka; T Kurosawa; H Seto; K Katsumi; M Onoue; H Ishida; A Iseki; T Nara; K Morohashi; T Horie; Y Onomura; M Narusawa; N Aoyagi; K Takami; M Yamaoka; Y Inoue; Akio Matsukage; Shonen Yoshida; Kengo Sakaguchi
Screening of inhibitor of eukaryotic DNA polymerases produced by microorganisms.
The Journal of antibiotics 1996;49(5):491-2.