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Shigehiko Mizutani

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Physiology

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Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani; Akihiro Nawa; Fumitaka Kikkawa
The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells.
Masakazu Ishii; Katsuhiko Naruse; Akira Hattori; Masafumi Tsujimoto; Shoichi Ishiura; Yasushi Numaguchi; Toyoaki Murohara; Hiroshi Kobayashi; Shigehiko Mizutani
Oxytocin hypersensitivity in pregnant P-LAP deficient mice.
Masakazu Ishii; Akira Hattori; Yasushi Numaguchi; Masafumi Tsujimoto; S Ishiura; Honami Kobayashi; Toyoaki Murohara; J-W Wright; Shigehiko Mizutani
The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan.

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2010: Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani; Akihiro Nawa; Fumitaka Kikkawa
The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells.
Cancer science 2010;101(2):347-54.
2009: Masakazu Ishii; Katsuhiko Naruse; Akira Hattori; Masafumi Tsujimoto; Shoichi Ishiura; Yasushi Numaguchi; Toyoaki Murohara; Hiroshi Kobayashi; Shigehiko Mizutani
Oxytocin hypersensitivity in pregnant P-LAP deficient mice.
Life sciences 2009;84(19-20):668-72.
2008: Masakazu Ishii; Akira Hattori; Yasushi Numaguchi; Masafumi Tsujimoto; S Ishiura; Honami Kobayashi; Toyoaki Murohara; J-W Wright; Shigehiko Mizutani
The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(12):887-91.
2008: Shigehiko Mizutani; Masakazu Ishii; Akira Hattori; Seiji Nomura; Yasushi Numaguchi; Masafumi Tsujimoto; Hiroshi Kobayshi; Toyoaki Murohara; John W Wright
New insights into the importance of aminopeptidase A in hypertension.
Heart failure reviews 2008;13(3):273-84.
2007: Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
Possible involvement of SDF-1alpha/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells.
Cell and tissue research 2007;330(2):221-9.
2007: Mamoru Yamashita; Hiroaki Kajiyama; Mikio Terauchi; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.
International journal of cancer. Journal international du cancer 2007;120(10):2243-50.
2007: Shigehiko Mizutani; Kiyosumi Shibata; Fumitaka Kikkawa; Akira Hattori; Masafumi Tsujimoto; Masakazu Ishii; Hiroshi Kobayashi
Essential role of placental leucine aminopeptidase in gynecologic malignancy.
Expert opinion on therapeutic targets 2007;11(4):453-61.
2007: Mikio Terauchi; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.
BMC cancer 2007;7():140.
2007: Kiyosumi Shibata; Hiroaki Kajiyama; Kazuhiko Ino; Akihiro Nawa; Seiji Nomura; Shigehiko Mizutani; Fumitaka Kikkawa
P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling.
BMC cancer 2007;7():15.
2006: Toko Harata; Hisao Ando; Akira Iwase; Tetsuro Nagasaka; Shigehiko Mizutani; Fumitaka Kikkawa
Localization of angiotensin II, the AT1 receptor, angiotensin-converting enzyme, aminopeptidase A, adipocyte-derived leucine aminopeptidase, and vascular endothelial growth factor in the human ovary throughout the menstrual cycle.
Fertility and sterility 2006;86(2):433-9.
2006: Yuji Shimomura; Hisao Ando; Kazunori Furugori; Hiroaki Kajiyama; Miyabi Suzuki; Akira Iwase; Shigehiko Mizutani; Fumitaka Kikkawa
Possible involvement of crosstalk cell-adhesion mechanism by endometrial CD26/dipeptidyl peptidase IV and embryonal fibronectin in human blastocyst implantation.
Molecular human reproduction 2006;12(8):491-5.
2006: Mikihito Takeuchi; Atsuo Itakura; Mayumi Okada; Shigehiko Mizutani; Fumitaka Kikkawa
Impaired insulin-regulated membrane aminopeptidase translocation to the plasma membrane in adipocytes of Otsuka Long Evans Tokushima Fatty rats.
Nagoya journal of medical science 2006;68(3-4):155-63.
2006: Fumi Shido; Tomomi Ito; Seiji Nomura; Eiko Yamamoto; Seiji Sumigama; Kazuhiko Ino; Atsuo Itakura; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani; Fumitaka Kikkawa
Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells.
Endocrinology 2006;147(4):1780-8.
2006: Chihiro Kondo; Kiyosumi Shibata; Mikio Terauchi; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Akihiro Nawa; Shigehiko Mizutani; Fumitaka Kikkawa
A novel role for placental leucine aminopeptidase (P-LAP) as a determinant of chemoresistance in endometrial carcinoma cells.
International journal of cancer. Journal international du cancer 2006;118(6):1390-4.
2006: Seiji Nomura; Takayasu Suganuma; Takahiro Suzuki; Tomomi Ito; Hiroaki Kajiyama; Mayumi Okada; Kiyosumi Shibata; Kazuhiko Ino; Fumitaka Kikkawa; Shigehiko Mizutani
Endometrioid adenocarcinoma arising from endometriosis during 2 years of estrogen replacement therapy after total hysterectomy and bilateral salpingo-oophorectomy.
Acta obstetricia et gynecologica Scandinavica 2006;85(8):1019-21.
2005: Eiko Yamamoto; Tomomi Ito; A Abe; F Sido; Kazuhiko Ino; Atsuo Itakura; Shigehiko Mizutani; S Dovat; Seiji Nomura; Fumitaka Kikkawa
Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion.
Molecular human reproduction 2005;11(11):825-31.
2005: Seiji Nomura; Fumitaka Kikkawa; Shigehiko Mizutani
[Placental leucine aminopeptidase (P-LAP)].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():469-71.
2005: Fumitaka Kikkawa; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Dipeptidyl peptidase IV in tumor progression.
Biochimica et biophysica acta 2005;1751(1):45-51.
2005: Seiji Nomura; Tomomi Ito; Eiko Yamamoto; Seiji Sumigama; Akira Iwase; Mayumi Okada; Kiyosumi Shibata; Hisao Ando; Kazuhiko Ino; Fumitaka Kikkawa; Shigehiko Mizutani
Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy.
Biochimica et biophysica acta 2005;1751(1):19-25.
2005: M Nishikawa; Atsuo Itakura; Mitsuaki Ito; Mikihito Takeuchi; Yuzo Sato; Hiroaki Kajiyama; Shigehiko Mizutani; Fumitaka Kikkawa
Changes in placental dipeptidyl peptidase IV in preeclampsia with intrauterine growth restriction.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(7):408-13.
2005: Michiyo Sano; Atsuo Itakura; Mitsuaki Ito; Mikihito Takeuchi; Mayumi Okada; Tomomi Kotani; Shigehiko Mizutani; Fumitaka Kikkawa
Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells.
Medical science monitor : international medical journal of experimental and clinical research 2005;11(7):BR195-9.
2005: Kiyosumi Shibata; Hiroaki Kajiyama; Yayoi Mizokami; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani; Mikio Terauchi; Fumitaka Kikkawa
Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia.
Gynecologic oncology 2005;98(1):11-8.
2005: Mami Nomura; Seiji Nomura; Takashi Mitsui; Masaki Suzuki; Honami Kobayashi; Tomomi Ito; Atsuo Itakura; Fumitaka Kikkawa; Shigehiko Mizutani
Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats.
American journal of hypertension 2005;18(4 Pt 1):538-43.
2005: Takayasu Suganuma; Kazuhiko Ino; Kiyosumi Shibata; Hiroaki Kajiyama; Tetsuro Nagasaka; Shigehiko Mizutani; Fumitaka Kikkawa
Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2686-94.
2005: Hiroaki Kajiyama; Kiyosumi Shibata; Mikio Terauchi; Takanori Morita; Kazuhiko Ino; Shigehiko Mizutani; Fumitaka Kikkawa
Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1798-808.
2005: Akira Iwase; Hisao Ando; Keiko Kuno; Shigehiko Mizutani
Use of follicle-stimulating hormone test to predict poor response in in vitro fertilization.
Obstetrics and gynecology 2005;105(3):645-52.
2005: Mikio Terauchi; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani; Fumitaka Kikkawa
Anti-progressive effect of neutral endopeptidase 24.11 (NEP/CD10) on cervical carcinoma in vitro and in vivo.
Oncology 2005;69(1):52-62.
2005: Kiyosumi Shibata; Fumitaka Kikkawa; Yayoi Mizokami; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Possible involvement of adipocyte-derived leucine aminopeptidase via angiotensin II in endometrial carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005;26(1):9-16.
2005: Yoshiaki Kotani; Akira Iwase; Hisao Ando; Shigehiko Mizutani
Oxytocin-induced prostaglandin E2 (PGE2) synthesis is regulated by progesterone via oxytocinase in Ishikawa cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(1):4-9.
2005: Yasutaka Murata; Atsuo Itakura; Katsuji Matsuzawa; Akihisa Okumura; Kenji Wakai; Shigehiko Mizutani
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia.
Brain & development 2005;27(1):17-21.
2004: Kiyosumi Shibata; Fumitaka Kikkawa; Chihiro Kondo; Yayoi Mizokami; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma.
Gynecologic oncology 2004;95(2):307-13.
2004: H Ando; S Toda; M Harada; S Yoshida; I Kondo; T Masahashi; Shigehiko Mizutani
Which infertile women should be indicated for sonohysterography?
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2004;24(5):566-71.
2004: Daijiro Shibata; Hisao Ando; Akira Iwase; Tetsuro Nagasaka; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani
Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(9):1169-75.
2004: Kazuhiko Ino; Kiyosumi Shibata; Hiroaki Kajiyama; Fumitaka Kikkawa; Shigehiko Mizutani
Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies.
Biological chemistry 2004;385(8):683-90.
2004: Seiji Sumigama; Tomomi Ito; Hiroaki Kajiyama; Kiyosumi Shibata; Koji Tamakoshi; Fumitaka Kikkawa; Trevor Williams; Michael A Tainsky; Seiji Nomura; Shigehiko Mizutani
Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha.
Oncogene 2004;23(32):5496-504.
2004: Yayoi Mizokami; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Fumitaka Kikkawa; Shigehiko Mizutani
Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma.
International journal of cancer. Journal international du cancer 2004;110(5):652-9.
2004: Takashi Mitsui; Seiji Nomura; Atsuo Itakura; Shigehiko Mizutani
Role of aminopeptidases in the blood pressure regulation.
Biological & pharmaceutical bulletin 2004;27(6):768-71.
2004: Fumitaka Kikkawa; Mika Mizuno; Kiyosumi Shibata; Hiroaki Kajiyama; Takanori Morita; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Activation of invasiveness of cervical carcinoma cells by angiotensin II.
American journal of obstetrics and gynecology 2004;190(5):1258-63.
2004: Setsuko Goto; Kazuhiko Ino; Takashi Mitsui; Fumitaka Kikkawa; Takanobu Suzuki; Seiji Nomura; Shigehiko Mizutani
Survival rates of patients with choriocarcinoma treated with chemotherapy without hysterectomy: effects of anticancer agents on subsequent births.
Gynecologic oncology 2004;93(2):529-35.
2004: Takayasu Suganuma; Kazuhiko Ino; Kiyosumi Shibata; Seiji Nomura; Hiroaki Kajiyama; Fumitaka Kikkawa; Tsuruoka Nobuo; Shigehiko Mizutani
Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor.
Laboratory investigation; a journal of technical methods and pathology 2004;84(5):639-48.
2004: Takanori Morita; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Shigehiko Mizutani
Oxytocin inhibits the progression of human ovarian carcinoma cells in vitro and in vivo.
International journal of cancer. Journal international du cancer 2004;109(4):525-32.
2004: Masayuki Nakata; Seiji Nomura; Yoko Ikoma; Seiji Sumigama; Fumi Shido; Tomomi Ito; Mayumi Okada; Fumitaka Kikkawa; Masafumi Tsujimoto; Shigehiko Mizutani
Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells.
Regulatory peptides 2004;117(3):187-93.
2004: Honami Kobayashi; Takashi Mitsui; Seiji Nomura; Yasumasa Ohno; Kenji Kadomatsu; Takashi Muramatsu; Tetsuro Nagasaka; Shigehiko Mizutani
Expression of glucose transporter 4 in the human pancreatic islet of Langerhans.
Biochemical and biophysical research communications 2004;314(4):1121-5.
2004: Norio Ito; Seiji Nomura; Akira Iwase; Tomomi Ito; Fumitaka Kikkawa; Masafumi Tsujimoto; Shoichi Ishiura; Shigehiko Mizutani
ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase.
Biochemical and biophysical research communications 2004;314(4):1008-13.
2004: Fumitaka Kikkawa; Kiyosumi Shibata; Takahiro Suzuki; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Shigehiko Mizutani
Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells.
Placenta 2004;25(2-3):176-83.
2004: Kiyosumi Shibata; Fumitaka Kikkawa; Yuka Suzuki; Yayoi Mizokami; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Tetsuro Nagasaka; Shigehiko Mizutani
Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma.
Oncology 2004;66(4):288-95.
2004: Honami Kobayashi; Seiji Nomura; Takashi Mitsui; Tomomi Ito; Naohiko Kuno; Yasumasa Ohno; Kenji Kadomatsu; Takashi Muramatsu; Tetsuro Nagasaka; Shigehiko Mizutani
Tissue distribution of placental leucine aminopeptidase/oxytocinase during mouse pregnancy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(1):113-21.
2004: Kiyosumi Shibata; Fumitaka Kikkawa; Yuka Suzuki; Mikio Terauchi; Hiroaki Kajiyama; Kazuhiko Ino; Shigehiko Mizutani
Usefulness of preoperative chemoradiation in locally advanced cervical carcinoma.
Gynecologic and obstetric investigation 2004;57(2):93-9.
2003: Yoshiteru Watanabe; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani
Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6497-503.
2003: Kazuhiko Ino; Fumitaka Kikkawa; Takahiro Suzuki; Hiroaki Kajiyama; Kiyosumi Shibata; Seiji Nomura; Atsuo Itakura; Mitsuaki Ito; Tetsuro Nagasaka; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells.
Laboratory investigation; a journal of technical methods and pathology 2003;83(12):1799-809.
2003: Yoshimitsu Niwa; Toru Nakanishi; Kazuo Kuzuya; Akihiro Nawa; Shigehiko Mizutani
Salvage treatment with docetaxel for recurrent epithelial ovarian cancer.
International journal of clinical oncology 2003;8(6):343-7.
2003: Y Tsukahara; Atsuo Itakura; Yasumasa Ohno; Hisao Ando; Shigehiko Mizutani
Umbilical plasma kininase I activity in fetal hypoxia.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(10):583-7.
2003: Minako Nishikawa; Nagao Bitoh; Fumitaka Kikkawa; Emiko Horii; Shigehiko Mizutani
Bilateral preaxial polydactyly: a possible dominant inheritant.
Archives of gynecology and obstetrics 2003;268(4):337-9.
2003: Kumi Iwanaga; Seiji Nomura; Tomomi Ito; Yoko Ikoma; Eiko Yamamoto; Mayumi Okada; Atsuo Itakura; Fumitaka Kikkawa; Masafumi Tsujimoto; Shigehiko Mizutani
Placental leucine aminopeptidase/oxytocinase gene regulation by activator protein-2 in BeWo cell model of human trophoblast differentiation.
FEBS letters 2003;552(2-3):120-4.
2003: Kiyosumi Shibata; Fumitaka Kikkawa; M Mika; Y Suzuki; Hiroaki Kajiyama; Kazuhiko Ino; Shigehiko Mizutani
Neoadjuvant chemotherapy for FIGO stage III or IV ovarian cancer: Survival benefit and prognostic factors.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2003;13(5):587-92.
2003: Takahiro Suzuki; Kazuhiko Ino; Fumitaka Kikkawa; Kiyosumi Shibata; Hiroaki Kajiyama; Takanori Morita; Tetsuro Nagasaka; Shigehiko Mizutani
Cushing's syndrome due to ovarian serous adenocarcinoma secreting multiple endocrine substances: a case report and immunohistochemical analysis.
Gynecologic oncology 2003;90(3):662-6.
2003: Hideo Kazeto; Seiji Nomura; Norio Ito; Tomomi Ito; Yoshiteru Watanabe; Hiroaki Kajiyama; Kiyosumi Shibata; Kazuhiko Ino; Koji Tamakoshi; Akira Hattori; Fumitaka Kikkawa; Tetsuro Nagasaka; Masafumi Tsujimoto; Shigehiko Mizutani
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2003;24(4):203-8.
2003: Kazuhiko Ino; Carlos Uehara; Fumitaka Kikkawa; Hiroaki Kajiyama; Kiyosumi Shibata; Takahiro Suzuki; Ei Ei Khin; Mitsuaki Ito; Mikihito Takeuchi; Atsuo Itakura; Shigehiko Mizutani
Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.
The Journal of clinical endocrinology and metabolism 2003;88(8):3973-82.
2003: Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Kiyosumi Shibata; Shigehiko Mizutani
Increased adhesion potency of ovarian carcinoma cells to mesothelial cells by overexpression of dipeptidyl peptidase IV.
International journal of cancer. Journal international du cancer 2003;105(6):779-83.
2003: Yasutaka Murata; Yasumasa Ohno; Atsuo Itakura; Mikihito Takeuchi; Yutaka Nakashima; Naohiko Kuno; Shigehiko Mizutani
Bestatin results in pathophysiological changes similar to preeclampsia in rats via induction of placental apoptosis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(6):343-8.
2003: Hisao Ando; Kazunori Furugori; Daijiro Shibata; Toko Harata; Yasutaka Murata; Shigehiko Mizutani
Dual renin-angiotensin blockade therapy in patients at high risk of early ovarian hyperstimulation syndrome receiving IVF and elective embryo cryopreservation: a case series.
Human reproduction (Oxford, England) 2003;18(6):1219-22.
2003: Atsuo Itakura; M Okamura; T Ohta; Shigehiko Mizutani
Conservative treatment of a second trimester cervicoisthmic pregnancy diagnosed by magnetic resonance imaging.
Obstetrics and gynecology 2003;101(5 Pt 2):1149-51.
2003: Yasumasa Ohno; Kumi Iwanaga; Atsuo Itakura; Shigehiko Mizutani
Increased intracranial blood flow volume in a preeclamptic woman with postpartum photophobia.
Obstetrics and gynecology 2003;101(5 Pt 2):1082-4.
2003: Yasutaka Murata; Hisao Ando; Tetsuro Nagasaka; Ikuo Takahashi; Kiyoshi Saito; Hiroyuki Fukugaki; Katsuji Matsuzawa; Shigehiko Mizutani
Successful pregnancy after bromocriptine therapy in an anovulatory woman complicated with ovarian hyperstimulation caused by follicle-stimulating hormone-producing plurihormonal pituitary microadenoma.
The Journal of clinical endocrinology and metabolism 2003;88(5):1988-93.
2003: Hiroaki Kajiyama; Fumitaka Kikkawa; Ei Ei Khin; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani
Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells.
Cancer research 2003;63(9):2278-83.
2003: Yuka Suzuki; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Seiji Nomura; Masafumi Tsujimoto; Shigehiko Mizutani
Possible role of placental leucine aminopeptidase in the antiproliferative effect of oxytocin in human endometrial adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1528-34.
2003: Mayumi Okada; Seiji Nomura; Yoko Ikoma; Eiko Yamamoto; Tomomi Ito; Takashi Mitsui; Koji Tamakoshi; Shigehiko Mizutani
Effects of postmenopausal hormone replacement therapy on HbA(1c) levels.
Diabetes care 2003;26(4):1088-92.
2003: Ei Ei Khin; Fumitaka Kikkawa; Kazuhiko Ino; Takahiro Suzuki; Kiyosumi Shibata; Hiroaki Kajiyama; Koji Tamakoshi; Shigehiko Mizutani
Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2003;22(2):175-80.
2003: Ei Ei Khin; Fumitaka Kikkawa; Kazuhiko Ino; Hiroaki Kajiyama; Takahiro Suzuki; Kiyosumi Shibata; Koji Tamakoshi; Tetsuro Nagasaka; Shigehiko Mizutani
Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade.
American journal of obstetrics and gynecology 2003;188(3):670-6.
2003: Norio Ito; Seiji Nomura; Akira Iwase; Tomomi Ito; Kazuhiko Ino; Tetsuro Nagasaka; Masafumi Tsujimoto; Miya Kobayashi; Shigehiko Mizutani
Ultrastructural localization of aminopeptidase A/angiotensinase and placental leucine aminopeptidase/oxytocinase in chorionic villi of human placenta.
Early human development 2003;71(1):29-37.
2003: Yoko Ikoma; Seiji Nomura; Tomomi Ito; Yoshinao Katsumata; Masayuki Nakata; Kumi Iwanaga; Mayumi Okada; Fumitaka Kikkawa; Koji Tamakoshi; Tetsuro Nagasaka; Masafumi Tsujimoto; Shigehiko Mizutani
Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells.
Molecular human reproduction 2003;9(2):103-10.
2003: Mika Mizuno; Fumitaka Kikkawa; Kiyosumi Shibata; Hiroaki Kajiyama; Takahiro Suzuki; Kazuhiko Ino; Michiyasu Kawai; Shigehiko Mizutani
Long-term prognosis of stage I ovarian carcinoma. Prognostic importance of intraoperative rupture.
Oncology 2003;65(1):29-36.
2003: Takashi Mitsui; Seiji Nomura; Mayumi Okada; Yasumasa Ohno; Honami Kobayashi; Yutaka Nakashima; Yasutaka Murata; Mikihito Takeuchi; Naohiko Kuno; Tetsuro Nagasaka; Jiyang O-Wang; Max D Cooper; Shigehiko Mizutani
Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice.
Molecular medicine (Cambridge, Mass.) 2003;9(1-2):57-62.
2003: Shigehiko Mizutani; Hiroaki Kajiyama; Takahiro Suzuki; Kiyosumi Shibata; Kazuhiko Ino; Fumitaka Kikkawa
Survival time and invasive activity due to dipeptidyl peptidase IV overexpression in ovarian carcinoma.
Advances in experimental medicine and biology 2003;524():253-6.
2003: Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Kiyosumi Shibata; Shigehiko Mizutani
Adhesion potency to mesothelial cells by overexpression of dipeptidyl peptidase IV.
Advances in experimental medicine and biology 2003;524():249-52.
2003: Hiroaki Kajiyama; Fumitaka Kikkawa; Kazuhiko Ino; Kiyosumi Shibata; Shigehiko Mizutani
Expression of CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma and its negative correlation with tumor grade.
Advances in experimental medicine and biology 2003;524():245-8.
2003: Tomomitsu Okamoto; Rong Niu; Shigehiko Mizutani; Satoru Yamada
Levels of placenta growth factor in gestational trophoblastic diseases.
American journal of obstetrics and gynecology 2003;188(1):135-40.
2002: Mari Ijima; Seiji Nomura; Mayumi Okada; Yoko Ikoma; Tomomi Ito; Takashi Mitsui; Osamu Maeda; Shigehiko Mizutani
Effects of age, hypertension and HRT on serum aminopeptidase A activity.
Maturitas 2002;43(3):215-21.
2002: Yutaka Nakashima; Yasumasa Ohno; Atsuo Itakura; Mikihito Takeuchi; Yasutaka Murata; Naohiko Kuno; Shigehiko Mizutani
Possible involvement of aminopeptidase A in hypertension in spontaneously hypertensive rats (SHRs) and change of refractoriness in response to angiotensin II in pregnant SHRs.
Journal of hypertension 2002;20(11):2233-8.
2002: Masao Nomura; Shin-Ichiro Tsukahara; Hisao Ando; Yoshinao Katsumata; Mayumi Okada; Atsuo Itakura; Seiji Nomura; Fumitaka Kikkawa; Tetsuro Nagasaka; Shigehiko Mizutani
Differential distribution of placental leucine aminopeptidase/oxytocinase and aminopeptidase A in human trophoblasts of normal placenta and complete hydatidiform mole.
Placenta 2002;23(8-9):631-9.
2002: Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Yoshiteru Watanabe; Mitsuaki Ito; Seiji Nomura; Atsuo Itakura; Masafumi Tsujimoto; Shigehiko Mizutani
Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.
Placenta 2002;23(6):483-9.
2002: Takahiro Suzuki; Kazuhiko Ino; Fumitaka Kikkawa; Carlos Uehara; Hiroaki Kajiyama; Kiyosumi Shibata; Shigehiko Mizutani
Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway.
Placenta 2002;23(6):475-82.
2002: Hiroaki Kajiyama; Fumitaka Kikkawa; Takahiro Suzuki; Kiyosumi Shibata; Kazuhiko Ino; Shigehiko Mizutani
Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma.
Cancer research 2002;62(10):2753-7.
2002: Hisao Ando; Tetsuro Nagasaka; Masao Nomura; Shin-Ichiro Tsukahara; Yoshiaki Kotani; Shigeru Toda; Yasutaka Murata; Atsuo Itakura; Shigehiko Mizutani
Premenstrual disappearance of aminopeptidase A in endometrial stromal cells around endometrial spiral arteries/arterioles during the decidual change.
The Journal of clinical endocrinology and metabolism 2002;87(5):2303-9.
2002: Mitsuaki Ito; Atsuo Itakura; Yasumasa Ohno; Masao Nomura; Takeshi Senga; Tetsuro Nagasaka; Shigehiko Mizutani
Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia.
The Journal of clinical endocrinology and metabolism 2002;87(4):1871-8.
2002: Atsuo Itakura; Osamu Kurauchi; Sachio Takashima; Koji Uchida; Mitsuaki Ito; Shigehiko Mizutani
Immunological detection of 4-hydroxynonenal protein adducts in developing pontine and Purkinje neurons and in karyorrhexis in pontosubicular neuronal necrosis.
Early human development 2002;67(1-2):19-28.
2002: Shigeru Toda; Hisao Ando; Tetsuro Nagasaka; Shin-Ichiro Tsukahara; Masao Nomura; Yoshiaki Kotani; Seiji Nomura; Fumitaka Kikkawa; Masafumi Tsujimoto; Shigehiko Mizutani
Existence of placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase in human endometrial epithelial cells.
The Journal of clinical endocrinology and metabolism 2002;87(3):1384-9.
2002: Tomomi Ito; Seiji Nomura; Mayumi Okada; Yoshinao Katsumata; Fumitaka Kikkawa; Tomohiro Rogi; Masafumi Tsujimoto; Shigehiko Mizutani
Ap-2 and Ikaros regulate transcription of human placental leucine aminopeptidase/oxytocinase gene.
Biochemical and biophysical research communications 2002;290(3):1048-53.
2002: Fumitaka Kikkawa; Kiyosumi Shibata; Kazuhiko Ino; Seiji Nomura; Hiroaki Kajiyama; Takahiro Suzuki; Michiyasu Kawai; Shigehiko Mizutani
Preoperative findings in non-gynecologic carcinomas metastasizing to the ovaries.
Gynecologic and obstetric investigation 2002;54(4):221-7.
2002: Hiroaki Kajiyama; Fumitaka Kikkawa; Osamu Maeda; Takahiro Suzuki; Kazuhiko Ino; Shigehiko Mizutani
Increased expression of dipeptidyl peptidase IV in human mesothelial cells by malignant ascites from ovarian carcinoma patients.
Oncology 2002;63(2):158-65.
2002: Fumitaka Kikkawa; Kazuhiko Ino; Seiji Nomura; Hisatake Ishikawa; Kazuo Kuzuya; Osamu Yamamuro; Iwao Kobayashi; Michiyasu Kawai; Shigehiko Mizutani
Prognostic factors of secondary ovarian carcinoma.
Oncology 2002;63(2):124-9.
2002: Yasumasa Ohno; Atsuo Itakura; Michiyo Sano; Shigehiko Mizutani
Pure red cell aplasia and acute hepatitis during pregnancy.
Gynecologic and obstetric investigation 2002;53(2):112-3.
2002: H Itoh; Atsuo Itakura; Osamu Kurauchi; M Okamura; H Nakamura; Shigehiko Mizutani
Hepatocyte growth factor in human breast milk acts as a trophic factor.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(1):16-20.
2002: Yasumasa Ohno; Michiyasu Kawai; Yoshitaro Arii; Shigehiko Mizutani
Effect of prostaglandin E1 on ophthalmic artery velocimetry in a pre-eclamptic woman with visual disturbance caused by retinal arterial narrowing.
Gynecologic and obstetric investigation 2002;53(1):68-70.
2001: Kazuo Kuzuya; H Ishikawa; Toru Nakanishi; Fumitaka Kikkawa; Akihiro Nawa; H Fujimura; A Iwase; Yoshitaro Arii; Michiyasu Kawai; SE Hattori; K Sakakibara; E Sasayama; Y Furuhashi; T Suzuki; Shigehiko Mizutani
Optimal doses of paclitaxel and carboplatin combination chemotherapy for ovarian cancer: a phase I modified continual reassessment method study.
International journal of clinical oncology 2001;6(6):271-8.
2001: Kazuhiko Ino; Takashi Mitsui; Seiji Nomura; Fumitaka Kikkawa; Shigehiko Mizutani
Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature.
Gynecologic oncology 2001;83(3):601-4.
2001: Koichi Akashi; T Nagasaka; N Nakashim; T Harada; Tomomitsu Okamoto; Shigehiko Mizutani; H Ishiko
Squamous cell carcinoma of the vulva and adjacent lesions treated at Nagoya University Hospital from 1965 to 1997.
Nagoya journal of medical science 2001;64(3-4):109-21.
2001: Yoshinao Katsumata; Seiji Nomura; Kazuhiko Ino; Kumi Iwanaga; Nobuyuki Kurosawa; Tomomi Ito; Mayumi Okada; Masafumi Tsujimoto; Fumitaka Kikkawa; Shigehiko Mizutani
Progesterone stimulates the expression of aminopeptidase A/angiotensinase in human choriocarcinoma cells.
Placenta 2001;22(10):831-6.
2001: Tomomi Ito; Seiji Nomura; Mayumi Okada; Yoshinao Katsumata; Akira Iwase; Fumitaka Kikkawa; Masafumi Tsujimoto; Shigehiko Mizutani
Transcriptional regulation of human placental leucine aminopeptidase/oxytocinase gene.
Molecular human reproduction 2001;7(9):887-94.
2001: Akira Iwase; Seiji Nomura; Shigehiko Mizutani
Characterization of a secretase activity for placental leucine aminopeptidase.
Archives of biochemistry and biophysics 2001;393(1):163-9.
2001: Carlos Uehara; Kazuhiko Ino; Takahiro Suzuki; Hiroaki Kajiyama; Fumitaka Kikkawa; Tetsuro Nagasaka; Shigehiko Mizutani
Upregulation of neutral endopeptidase expression and enzymatic activity during the differentiation of human choriocarcinoma cells.
Placenta 2001;22(6):540-9.
2001: H Kozaki; Atsuo Itakura; M Okamura; Yasumasa Ohno; K Wakai; Shigehiko Mizutani
Maternal serum placental leucine aminopeptidase (P-LAP)/oxytocinase and preterm delivery.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2001;73(3):207-13.
2001: Tomomitsu Okamoto; Rong Niu; K Matsuo; M Furuhashi; M Ohsawa; Shigehiko Mizutani; H Suzuki
Human chorionic gonadotropin beta-core fragment is directly produced by cancer cells.
Life sciences 2001;68(8):861-72.
2001: K Iwase; Tomomitsu Okamoto; R Nui; Shigehiko Mizutani
Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar disease.
Gynecologic and obstetric investigation 2001;51(4):228-32.
2001: Takahiro Suzuki; Fumitaka Kikkawa; Kazuhiko Ino; Tetsuro Nagasaka; Koji Tamakoshi; Shigehiko Mizutani
Imbalance between neutral endopeptidase 24.11 and endothelin-1 expression in human endometrial carcinoma.
Oncology 2001;60(3):258-67.
2000: Kazuhiko Ino; Takahiro Suzuki; Carlos Uehara; Tetsuro Nagasaka; Tomomitsu Okamoto; Fumitaka Kikkawa; Shigehiko Mizutani
The expression and localization of neutral endopeptidase 24.11/CD10 in human gestational trophoblastic diseases.
Laboratory investigation; a journal of technical methods and pathology 2000;80(11):1729-38.
2000: Y Nakanishi; Seiji Nomura; Mayumi Okada; Tomomi Ito; Yoshinao Katsumata; Fumitaka Kikkawa; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani
Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta.
Placenta 2000;21(7):628-34.
2000: Y Hariyama; Atsuo Itakura; M Okamura; Mitsuaki Ito; Yasutaka Murata; Tetsuro Nagasaka; H Nakazato; Shigehiko Mizutani
Placental aminopeptidase A as a possible barrier of angiotensin II between mother and fetus.
Placenta 2000;21(7):621-7.
2000: S Yoshida; M Shibata; S Yamamoto; M Hagihara; N Asai; M Takahashi; Shigehiko Mizutani; Takashi Muramatsu; Kenji Kadomatsu
Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain.
European journal of biochemistry / FEBS 2000;267(14):4372-80.
2000: Hisao Ando; M Kobayashi; S Toda; F Kikkawa; T Masahashi; Shigehiko Mizutani
Establishment of a ciliated epithelial cell line from human Fallopian tube.
Human reproduction (Oxford, England) 2000;15(7):1597-603.
2000: H Fujimura; Kazuhiko Ino; Tetsuro Nagasaka; N Nakashima; H Nakazato; Fumitaka Kikkawa; Shigehiko Mizutani
Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression.
Oncology 2000;58(4):342-52.
2000: E Liu; Aye Aye Thant; Fumitaka Kikkawa; H Kurata; S Tanaka; Akihiro Nawa; Shigehiko Mizutani; Satoru Matsuda; H Hanafusa; Michinari Hamaguchi
The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1.
Cancer research 2000;60(9):2361-4.
2000: N Yamahara; Seiji Nomura; Takahiro Suzuki; Atsuo Itakura; Mitsuaki Ito; Tomomitsu Okamoto; Masafumi Tsujimoto; H Nakazato; Shigehiko Mizutani
Placental leucine aminopeptidase/oxytocinase in maternal serum and placenta during normal pregnancy.
Life sciences 2000;66(15):1401-10.
2000: Rong Niu; Tomomitsu Okamoto; K Iwase; Seiji Nomura; Shigehiko Mizutani
Quantitative analysis of matrix metalloproteinases-2 and -9, and their tissue inhibitors-1 and -2 in human placenta throughout gestation.
Life sciences 2000;66(12):1127-37.
2000: Fumitaka Kikkawa; Katsuji Matsuzawa; Yoshitaro Arii; Michiyasu Kawai; Iwao Kobayashi; N Nakashima; Shigehiko Mizutani
Randomized trial of cisplatin and carboplatin versus cisplatin, vinblastine and bleomycin in ovarian cancer.
Gynecologic and obstetric investigation 2000;50(4):269-74.
2000: H Fujimura; Fumitaka Kikkawa; H Oguchi; N Nakashima; Shigehiko Mizutani
Adjuvant chemotherapy including cisplatin in endometrial carcinoma.
Gynecologic and obstetric investigation 2000;50(2):127-32.
2000: Kazuhiko Ino; Tetsuro Nagasaka; Tomomitsu Okamoto; Carlos Uehara; H Nakazato; N Nakashima; Shigehiko Mizutani
Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues.
Placenta 2000;21(1):63-72.
1999: M Okamura; Shigehiko Mizutani; A Itakura
[Human placental lactogen (hPL)].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():299-301.
1999: J Horio; Seiji Nomura; Mayumi Okada; Yoshinao Katsumata; Y Nakanishi; Y Kumano; S Takami; M Kinoshita; Masafumi Tsujimoto; H Nakazato; Shigehiko Mizutani
Structural organization of the 5'-end and chromosomal assignment of human placental leucine aminopeptidase/insulin-regulated membrane aminopeptidase gene.
Biochemical and biophysical research communications 1999;262(1):269-74.
1999: M Okamura; Osamu Kurauchi; Atsuo Itakura; S Naganawa; Yoshio Watanabe; Shigehiko Mizutani
Fetal sacrococcygeal teratoma visualized by ultra-fast T2 weighted magnetic resonance imaging.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1999;65(2):191-3.
1998: Shigehiko Mizutani
Physiological roles of placental proteases in feto-placental homeostasis.
Nagoya journal of medical science 1998;61(3-4):85-95.
1998: A Udagawa; Tomomitsu Okamoto; S Nomura; K Matsuo; H Suzuki; Shigehiko Mizutani
Human chorionic gonadotropin beta-core fragment is present in the human placenta.
Molecular and cellular endocrinology 1998;139(1-2):171-8.
1998: Naohiko Kuno; Kenji Kadomatsu; QW Fan; M Hagihara; T Senda; Shigehiko Mizutani; Takashi Muramatsu
Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily.
FEBS letters 1998;425(2):191-4.
1998: Kiyosumi Shibata; Fumitaka Kikkawa; Akihiro Nawa; Aye Aye Thant; Keiko Naruse; Shigehiko Mizutani; Michinari Hamaguchi
Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells.
Cancer research 1998;58(5):900-3.
1998: Seiji Nomura; Tomomitsu Okamoto; K Matsuo; K Iwase; T Nakanishi; H Suzuki; Shigehiko Mizutani
Serum and tissue vascular endothelial growth factor levels in hydatidiform mole.
Life sciences 1998;63(20):1793-805.
1998: M Okamura; Osamu Kurauchi; Atsuo Itakura; S Morikawa; N Suganuma; Shigehiko Mizutani; Y Tomoda
Hepatocyte growth factor in human amniotic fluid promotes the migration of fetal small intestinal epithelial cells.
American journal of obstetrics and gynecology 1998;178(1 Pt 1):175-9.
1997: Atsuo Itakura; Osamu Kurauchi; S Morikawa; M Okamura; Kazunori Furugori; Shigehiko Mizutani
Involvement of hepatocyte growth factor in formation of bronchoalveolar structures in embryonic rat lung in primary culture.
Biochemical and biophysical research communications 1997;241(1):98-103.
1997: S Morikawa; Atsuo Itakura; Fumio Hayakawa; Shigehiko Mizutani; Katsuji Matsuzawa; Osamu Kurauchi
Timing of insults causing abnormal outcome in preterm infants 1989-1992.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1997;59(1):1-6.
1997: Kazunori Furugori; Osamu Kurauchi; Atsuo Itakura; Y Kanou; Yuji Murata; Shigehiko Mizutani; Hisao Seo; Y Tomoda; T Nakamura
Levels of hepatocyte growth factor and its messenger ribonucleic acid in uncomplicated pregnancies and those complicated by preeclampsia.
The Journal of clinical endocrinology and metabolism 1997;82(8):2726-30.
1997: M Okada; A Suzuki; K Mizuno; Y Asada; Y Ino; Takehito Kuwayama; Koji Tamakoshi; Shigehiko Mizutani; Y Tomoda
Effects of 17 beta-estradiol and progesterone on migration of human monocytic THP-1 cells stimulated by minimally oxidized low-density lipoprotein in vitro.
Cardiovascular research 1997;34(3):529-35.
1997: Atsuo Itakura; Osamu Kurauchi; S Morikawa; Kazunori Furugori; Shigehiko Mizutani; Y Tomoda
Human amniotic fluid motogenic activity for fetal alveolar type II cells by way of hepatocyte growth factor.
Obstetrics and gynecology 1997;89(5 Pt 1):729-33.
1997: S Morikawa; Osamu Kurauchi; M Tanaka; M Yoneda; K Uchida; Atsuo Itakura; Kazunori Furugori; Shigehiko Mizutani; Y Tomoda
Increased mitochondrial damage by lipid peroxidation in trophoblast cells of preeclamptic placentas.
Biochemistry and molecular biology international 1997;41(4):767-75.
1997: Naohiko Kuno; Shigehiko Mizutani; Yasumasa Ohno; K Goto; Atsuo Itakura; I Kondo; Osamu Kurauchi; Fumitaka Kikkawa; Y Tomoda
Possible involvement of placental proteases in bradykinin (BK) degradation.
Reproduction, fertility, and development 1997;9(6):633-9.
1997: A Suzuki; K Mizuno; Y Asada; Y Ino; Takehito Kuwayama; M Okada; Shigehiko Mizutani; Y Tomoda
Effects of 17beta-estradiol and progesterone on the adhesion of human monocytic THP-1 cells to human female endothelial cells exposed to minimally oxidized LDL.
Gynecologic and obstetric investigation 1997;44(1):47-52.
1997: M Okamura; Atsuo Itakura; Osamu Kurauchi; Fumio Hayakawa; Shigehiko Mizutani; Y Tomoda
Fetal heart rate patterns associated with periventricular leukomalacia.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1997;56(1):13-8.
1996: Seiji Nomura; S Goto; K Ino; T Nakanishi; Tomomitsu Okamoto; H Mano; Osamu Kurauchi; Shigehiko Mizutani; Y Tomoda
Autocrine mechanism of epidermal growth factor in choriocarcinoma cell proliferation.
Molecular and cellular endocrinology 1996;124(1-2):63-9.
1996: Atsuo Itakura; Osamu Kurauchi; Fumio Hayakawa; Katsuji Matsuzawa; Shigehiko Mizutani; Y Tomoda
Timing of periventricular leukomalacia using neonatal electroencephalography.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1996;55(2):111-5.
1996: A Suzuki; K Mizuno; Y Ino; M Okada; F Kikkawa; Shigehiko Mizutani; Y Tomoda
Effects of 17 beta-estradiol and progesterone on growth-factor-induced proliferation and migration in human female aortic smooth muscle cells in vitro.
Cardiovascular research 1996;32(3):516-23.
1996: Shigehiko Mizutani; Y Tomoda
Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia.
American journal of hypertension 1996;9(6):591-7.
1996: Atsuo Itakura; Osamu Kurauchi; S Morikawa; Katsuji Matsuzawa; Shigehiko Mizutani; Y Tomoda
A prospective study on the relationship between intrapartum maternal group-B streptococcal concentration and signs of infection in neonates.
The journal of obstetrics and gynaecology research 1996;22(2):101-5.
1996: S A Mohamed; Shigehiko Mizutani; Atsuo Itakura; Naohiko Kuno; H T Salem; S A Mostafa; Osamu Kurauchi; Fumitaka Kikkawa; Y Tomoda
Relationship between the changes in maternal serum placental leucine aminopeptidase (P-LAP) activity and umbilical artery waveforms in normal pregnancy.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(3):147-9.
1996: Osamu Kurauchi; Y Ohno; Kazunori Furugori; Naohiko Kuno; S Morikawa; Atsuo Itakura; Shigehiko Mizutani; Y Tomoda
Comparative study of fetal behaviour in a case of monozygotic twins, one being anencephalic.
Gynecologic and obstetric investigation 1996;42(3):209-10.
1996: M Naruki; Shigehiko Mizutani; K Goto; M Tsujimoto; H Nakazato; Atsuo Itakura; K Mizuno; Osamu Kurauchi; Fumitaka Kikkawa; Y Tomoda
Oxytocin is hydrolyzed by an enzyme in human placenta that is identical to the oxytocinase of pregnancy serum.
Peptides 1996;17(2):257-61.
1996: Shigehiko Mizutani; K Goto; M Tsujimoto; H Nakazato; K Matsuzawa; Y Furuhashi; K Arii; Y Tomoda
Possible effects of placental leucine aminopeptidase on the regulation of brain-gut hormones in the fetoplacental unit.
Biology of the neonate 1996;69(5):307-17.
1995: Naohiko Kuno; Atsuo Itakura; Osamu Kurauchi; Shigehiko Mizutani; S Kazeto; Y Tomoda
Decrease in severity of intrauterine growth retardation in subsequent pregnancies.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1995;51(3):219-24.
1995: A Tanamura; S Nomura; Osamu Kurauchi; T Furui; Shigehiko Mizutani; Y Tomoda
Purification and characterization of 1,25(OH)2D3 receptor from human placenta.
Journal of obstetrics and gynaecology (Tokyo, Japan) 1995;21(6):631-9.
1995: Shigehiko Mizutani; M A Safwat; K Goto; M Tsujimoto; H Nakazato; Atsuo Itakura; M Mizuno; Osamu Kurauchi; Fumitaka Kikkawa; Y Tomoda
Initiating and responsible enzyme of arginine vasopressin degradation in human placenta and pregnancy serum.
Regulatory peptides 1995;59(3):371-8.
1995: Osamu Kurauchi; Y Ohno; Shigehiko Mizutani; Y Tomoda
Longitudinal monitoring of fetal behavior in twins when one is anencephalic.
Obstetrics and gynecology 1995;86(4 Pt 2):672-4.
1995: T Ishida; H Ando; S Nomura; K Ishikawa; Osamu Kurauchi; Shigehiko Mizutani; M Kobayashi; G Eguchi; Y Tomada
Establishment and characterization of human fetal liver epithelial cell line transfected with SV40 T antigen.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1995;209(3):251-6.
1995: Osamu Kurauchi; Atsuo Itakura; H Ando; Naohiko Kuno; Shigehiko Mizutani; Y Tomoda
The concentration of hepatocyte growth factor (HGF) in human amniotic fluid at second trimester: relation to fetal birth weight.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1995;27(7):335-8.
1995: O Kurauchi; T Furui; M Tanaka; Shigehiko Mizutani; T Ozawa; Y Tomoda
The study of mitochondrial gene modifications in human placenta.
Placenta 1995;16(5):461-7.
1995: Atsuo Itakura; Osamu Kurauchi; Shigehiko Mizutani; Y Tomoda; Katsuji Matsuzawa
[The levels of aztreonam in the cord bloods and tissues after administration to pregnant women].
The Japanese journal of antibiotics 1995;48(6):749-53.
1995: Atsuo Itakura; Osamu Kurauchi; S Morikawa; Katsuji Matsuzawa; Shigehiko Mizutani; Y Tomoda
[Neonatal EEG findings soon after birth in the intrauterine growth retarded infant].
Nihon Sanka Fujinka Gakkai zasshi 1995;47(2):109-14.
1995: Shigehiko Mizutani; G N Than; S Stock; N D Binder; S Mancuso; H S Wang; U Grundmann; Keiichi Isaka; M Takayama
Recent advances in placental peptide research: workshop report.
Reproduction, fertility, and development 1995;7(6):1443-50.
1995: Shigehiko Mizutani; K Goto; K Mizuno; Atsuo Itakura; Osamu Kurauchi; Fumitaka Kikkawa; Y Tomoda
Interaction between pregnancy-induced bioactive peptides and the placental proteases.
Reproduction, fertility, and development 1995;7(6):1431-6.
1995: Osamu Kurauchi; T Ishida; Y Ohno; H Ando; S Nomura; Shigehiko Mizutani; Y Tomoda
Serial fetal heart rate monitoring in monozygotic twin, one of which was anencephalic.
Archives of gynecology and obstetrics 1995;256(1):53-6.
1994: H Yagami; Osamu Kurauchi; Y Murata; T Okamoto; Shigehiko Mizutani; Y Tomoda
Expression of angiotensin-converting enzyme in human placenta and its physiologic role in the fetal circulation.
Obstetrics and gynecology 1994;84(3):453-7.
1994: K Ino; S Goto; Tomomitsu Okamoto; Seiji Nomura; Akihiro Nawa; Ken-Ichi Isobe; Shigehiko Mizutani; Y Tomoda
Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity.
Japanese journal of cancer research : Gann 1994;85(9):927-33.
1994: Shigehiko Mizutani
[Possible role of placental proteases via degradation of vasoactive peptides in the maternal and fetal blood pressure].
Nihon Sanka Fujinka Gakkai zasshi 1994;46(8):729-34.
1994: T Furui; Osamu Kurauchi; M Tanaka; Shigehiko Mizutani; T Ozawa; Y Tomoda
Decrease in cytochrome c oxidase and cytochrome oxidase subunit I messenger RNA levels in preeclamptic pregnancies.
Obstetrics and gynecology 1994;84(2):283-8.
1994: Y Ohno; M Kasugai; Osamu Kurauchi; Shigehiko Mizutani; Y Tomoda
Effect of interleukin 2 on the production of progesterone and prostaglandin E2 in human fetal membranes and its consequences for preterm uterine contractions.
European journal of endocrinology / European Federation of Endocrine Societies 1994;130(5):478-84.
1994: Atsuo Itakura; Osamu Kurauchi; Shigehiko Mizutani; Y Tomoda
Intrauterine growth retardation and fetal distress associated with the excessively long (160 cm) umbilical cord.
Archives of gynecology and obstetrics 1994;255(2):99-100.
1994: Y Ohno; H Ando; A Tanamura; Osamu Kurauchi; Shigehiko Mizutani; Y Tomoda
The value of Doppler ultrasound in the diagnosis and management of twin-to-twin transfusion syndrome.
Archives of gynecology and obstetrics 1994;255(1):37-42.
1993: H Yagami; Osamu Kurauchi; T Furui; Y Ohno; H Ando; S Nomura; A Tanamura; Shigehiko Mizutani; Y Tomoda; M Kasugai
[Determination of intrauterine pressure using catheter-tip transducer inserted outside fetal membranes].
Nihon Sanka Fujinka Gakkai zasshi 1993;45(12):1399-403.
1993: Shigehiko Mizutani; K Goto; Seiji Nomura; K Ino; S Goto; F Kikkawa; Osamu Kurauchi; G Goldstein; Y Tomoda
Possible action of human placental aminopeptidase N in feto-placental unit.
Research communications in chemical pathology and pharmacology 1993;82(1):65-80.
1993: Shigehiko Mizutani; Y Tomoda
Plasma angiotensin I concentration and serum placental leucine aminopeptidase (P-LAP) activities in puerperal hypertension.
Research communications in chemical pathology and pharmacology 1993;81(3):271-91.
1993: T Furui; Osamu Kurauchi; H Oguchi; S Nomura; Shigehiko Mizutani; Y Tomoda
Pregnancy and successful delivery in a patient with triple heart valve prosthesis.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1993;41(1):89-92.
1993: Shigehiko Mizutani; Seiji Nomura; R Hirose; M Kasugai; T Ishizuka; Y Tomoda
Intra-uterine fetal death due to pre-eclampsia which was misdiagnosed to be complicating with hepatitis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1993;25(3):187-9.
1993: H Ando; M Kasugai; Y Ishihara; Osamu Kurauchi; Nobuhiko Suganuma; Shigehiko Mizutani; Y Tomoda
Enhanced proliferation of fetal rat hepatocytes in primary culture induced by ritodrine.
American journal of obstetrics and gynecology 1993;168(2):693-7.
1992: Y Asada; Shigehiko Mizutani; M Kasugai; Osamu Kurauchi; Y Tomoda
Relationship between the changes in placental blood flow resistance assessed by Doppler technique and maternal serum placental aminopeptidases, which degrade vaso-active peptides, in pre-eclampsia.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(7):342-4.
1992: Shigehiko Mizutani; H Yokosawa; Y Tomoda
Degradation of oxytocin by the human placenta: effect of selective inhibitors.
Acta endocrinologica 1992;127(1):76-80.
1992: Y Yasuda; Shigehiko Mizutani; Osamu Kurauchi; M Kasugai; O Narita; Y Tomoda
Induction by cortisol of aminopeptidases production from the human placenta in tissue culture.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(3):110-4.
1992: Osamu Kurauchi; H Yagami; M Kasugai; Shigehiko Mizutani; Y Tomoda
Rapid determination of fetal sex using amniotic fluid cells and the polymerase chain reaction.
Archives of gynecology and obstetrics 1992;251(3):145-8.
1991: A Yamada; M Kasugai; Y Ohno; T Ishizuka; Shigehiko Mizutani; Y Tomoda
Antenatal diagnosis of twin-twin transfusion syndrome by Doppler ultrasound.
Obstetrics and gynecology 1991;78(6):1058-61.
1991: S Nomura; H Tokumitsu; Shigehiko Mizutani; O Narita; Y Tomada; H Hidaka
Identification of two subtypes of protein kinase C in human placenta.
Placenta 1991;12(6):605-13.
1991: Shigehiko Mizutani; Seiji Nomura; Osamu Kurauchi; M Kasugai; K Ino; S Goto; Y Tomoda
Aminopeptidases in the soluble fraction of human placenta.
Clinica chimica acta; international journal of clinical chemistry 1991;201(1-2):151-3.
1991: Y Nagata; Shigehiko Mizutani; Seiji Nomura; Osamu Kurauchi; M Kasugai; Y Tomoda
Purification and properties of human placental aminopeptidase B.
Enzyme 1991;45(4):165-73.
1991: K Ino; S Goto; A Kosaki; Seiji Nomura; E Asada; T Misawa; Y Furuhashi; Shigehiko Mizutani; Y Tomoda
Growth inhibitory effect of bestatin on choriocarcinoma cell lines in vitro.
Biotherapy (Dordrecht, Netherlands) 1991;3(4):351-7.
1990: Seiji Nomura; Shigehiko Mizutani; Osamu Kurauchi; M Kasugai; O Narita; Y Tomoda
Effects of low molecular weight peptides and divalent cations on degradation and binding of angiotensin II.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(8):444-8.
1990: Koichi Miyamura; K Imai; Shigehiko Mizutani
[Application of polymerase chain reaction for bone marrow transplantation].
[Rinshō ketsueki] The Japanese journal of clinical hematology 1990;31(5):597-602.
1990: Y Ito; Shigehiko Mizutani; Seiji Nomura; Osamu Kurauchi; M Kasugai; O Narita; Y Tomoda
Increased serum kininase I activity in pregnancy complicated by pre-eclampsia.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(4):252-5.
1990: Osamu Kurauchi; Shigehiko Mizutani; Seiji Nomura; M Kasugai; O Narita; Y Tomoda
A comparison of the binding of angiotensin II to human placenta between normal and severe pre-eclamptic pregnancy.
Journal of medicine 1990;21(3-4):209-16.
1989: Osamu Kurauchi; Shigehiko Mizutani; Seiji Nomura; Madoka Furuhashi; M Kasugai; Y Tomoda
Changes in the binding of angiotensin II to rat placental receptor by estrogen and progesterone.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1989;21(10):558-60.
1989: Y Kinoshita; Shigehiko Mizutani; Y Tomoda; T Maruyama; S Hattori; N Mano
[Pharmacokinetic and clinical study on cefodizime in obstetrics and gynecological field].
The Japanese journal of antibiotics 1989;42(10):2090-7.
1989: Madoka Furuhashi; Hisao Seo; Shigehiko Mizutani; O Narita; Y Tomoda; N Matsui
Expression of low density lipoprotein receptor gene in human placenta during pregnancy.
Molecular endocrinology (Baltimore, Md.) 1989;3(8):1252-6.
1989: Madoka Furuhashi; Shigehiko Mizutani; Osamu Kurauchi; M Kasugai; Y Tomoda
Effects of bestatin on intrauterine growth of rat fetuses.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1989;21(7):366-8.
1989: Shigehiko Mizutani; Y Ito; Seiji Nomura; Osamu Kurauchi; M Kasugai; O Narita; Y Tomoda
Increased sensitivity to bradykinin in pregnant rats.
Research communications in chemical pathology and pharmacology 1989;64(3):373-80.
1989: I Kondo; Nobuhiko Suganuma; T Kimura; Katsuji Matsuzawa; M Osawa; T Masahashi; Shigehiko Mizutani; O Narita; Y Tomoda
Effects of pregnancy, delivery and lactation in hyperprolactinemia with prolactin producing pituitary adenoma.
Nihon Sanka Fujinka Gakkai zasshi 1989;41(5):595-600.
1989: Seiji Nomura; Shigehiko Mizutani; Osamu Kurauchi; Madoka Furuhashi; M Kasugai; O Narita; Y Tomoda
A comparison of the hypotensive effects of Met-enkephalin in normotensive and spontaneously hypertensive rats.
Research communications in chemical pathology and pharmacology 1989;64(1):169-72.
1989: Osamu Kurauchi; Shigehiko Mizutani; Seiji Nomura; R Hotta; Y Ito; Y Asada; Madoka Furuhashi; M Kasugai; Y Tomoda
Effects of progesterone and estradiol on aminopeptidase A (AAP) and leucine aminopeptidase (LAP) activities in the pregnancy serum and placenta of the rat.
Experimental and clinical endocrinology 1989;93(1):90-4.
1989: Y Ito; Shigehiko Mizutani; Osamu Kurauchi; M Kasugai; O Narita; Y Tomoda
Purification and properties of microsomal carboxypeptidase N (kininase I) in human placenta.
Enzyme 1989;42(1):8-14.
1988: Shigehiko Mizutani; Osamu Kurauchi; Y Ito; O Narita; Y Tomoda
Positive effect of estradiol and progesterone in severe pre-eclampsia.
Experimental and clinical endocrinology 1988;92(2):161-70.
1988: Madoka Furuhashi; Shigehiko Mizutani; Osamu Kurauchi; M Kasugai; O Narita; Y Tomoda
In vitro degradation of opioid peptides by human placental aminopeptidase M.
Experimental and clinical endocrinology 1988;92(2):235-7.
1988: R Yamada; Shigehiko Mizutani; Osamu Kurauchi; K Okano; H Imaizumi; O Narita; Y Tomoda
Purification and characterization of human placental aminopeptidase A.
Enzyme 1988;40(4):223-30.
1987: Shigehiko Mizutani; H Taira; Osamu Kurauchi; Y Ito; H Imaizumi; Madoka Furuhashi; O Narita; Y Tomoda
Effect of microsomal leucine aminopeptidase from human placenta (microsomal P-LAP) on pressor response to infused angiotensin II (A-II) in rat.
Experimental and clinical endocrinology 1987;90(2):206-12.
1986: M Hori; F Kikkawa; Nobuhiko Suganuma; M Ohsawa; T Masahashi; M Asai; Shigehiko Mizutani; O Narita; Y Tomoda
Conservative surgery of infertile patients with pelvic endometriosis--factors affecting the pregnancy rate and expectancy.
Nihon Sanka Fujinka Gakkai zasshi 1986;38(10):1763-9.
1986: T Masahashi; M C Wu; M Ohsawa; M Asai; Y Ichikawa; K Hanai; H Kikkawa; Shigehiko Mizutani; O Narita; Y Tomoda
Spironolactone therapy for hyperandrogenic anovulatory women--clinical and endocrinological study.
Nihon Sanka Fujinka Gakkai zasshi 1986;38(1):95-101.
1985: O Narita; T Kimura; Nobuhiko Suganuma; M Osawa; Shigehiko Mizutani; T Masahashi; M Asai; Y Tomoda
Relationship between maternal prolactin levels during pregnancy and lactation in women with pituitary adenoma.
Nihon Sanka Fujinka Gakkai zasshi 1985;37(5):758-62.
1985: M Ohsawa; O Narita; Y Ichikawa; T Masahashi; M C Wu; Nobuhiko Suganuma; M Asai; Shigehiko Mizutani; Y Tomoda; N Matsui
Binding capacity of sex-hormone-binding globulin and free testosterone determination in evaluation of hirsute women.
Nihon Sanka Fujinka Gakkai zasshi 1985;37(3):416-20.