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Mahtab Moayeri

Research Profile

Chemicals & Drugs

Disorders

Anthrax

Living Beings

Anatomy

Co-author Network

Publications

TOP 3
Damilola D Phillips; Lacy Simons; Alexander N Wein; Yi Zhang; Devorah Crown; Rasem J Fattah; Elizabeth R Fischer; Rodolfo Ghirlando; Bryan T Hansen; Stephen H Leppla; Shihui Liu; Mahtab Moayeri; Ekaterina M Nestorovich; Clinton E Leysath
Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors.
Felice D'Agnillo; Mahtab Moayeri; Matthew C Williams; Jason M Warfel
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
Inka Sastalla; Devorah Crown; Stephen H Leppla; Seth L Masters; Andrew McKenzie; Mahtab Moayeri
Transcriptional analysis of the three Nlrp1 paralogs in mice.

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All Publications

2013: Damilola D Phillips; Lacy Simons; Alexander N Wein; Yi Zhang; Devorah Crown; Rasem J Fattah; Elizabeth R Fischer; Rodolfo Ghirlando; Bryan T Hansen; Stephen H Leppla; Shihui Liu; Mahtab Moayeri; Ekaterina M Nestorovich; Clinton E Leysath
Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors.
The Journal of biological chemistry 2013;288(13):9058-65.
2013: Felice D'Agnillo; Mahtab Moayeri; Matthew C Williams; Jason M Warfel
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
PloS one 2013;8(4):e62576.
2013: Inka Sastalla; Devorah Crown; Stephen H Leppla; Seth L Masters; Andrew McKenzie; Mahtab Moayeri
Transcriptional analysis of the three Nlrp1 paralogs in mice.
BMC genomics 2013;14():188.
2012: Jakob von Moltke; Samantha B Wang; Charles R Brown; Karsten Gronert; Alexander F Kintzer; Bryan A Krantz; Stephen H Leppla; Mahtab Moayeri; Norver J Trinidad; Nico van Rooijen; Russell E Vance
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
Nature 2012;490(7418):107-11.
2012: Mahtab Moayeri; Inka Sastalla; Stephen H Leppla
Anthrax and the inflammasome.
Microbes and infection / Institut Pasteur 2012;14(5):392-400.
2012: Guan-Sheng Jiao; Lisa Johns; Lynne Cregar-Hernandez; Devorah Crown; Seongjin Kim; Axel Lehrer; Stephen H Leppla; Stephen A Margosiak; Linda McKasson; Mahtab Moayeri; Banumathi Sankaran; April Thai; Teri Wong; Alan T Johnson
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorganic & medicinal chemistry letters 2012;22(6):2242-6.
2012: Joseph A Bellanti; German A Benavides; Chiayung Chu; Chunyan Guo; Arthur Karpas; Stephen H Leppla; Feng-Ying C Lin; Mahtab Moayeri; John B Robbins; Joseph Shiloach; Rachel Schneerson
Phase 1 study of a recombinant mutant protective antigen of Bacillus anthracis.
Clinical and vaccine immunology : CVI 2012;19(2):140-5.
2012: Inka Sastalla; Shixing Tang; Devorah Crown; Michael A Eckhaus; Indira K Hewlett; Stephen H Leppla; Shihui Liu; Mahtab Moayeri
Anthrax edema toxin impairs clearance in mice.
Infection and immunity 2012;80(2):529-38.
2012: Kristina A Hellmich; Stephen H Leppla; Jonathan L Levinsohn; Shihui Liu; Nolan Maier; Zachary L Newman; Inka Sastalla; Rasem Fattah; Mahtab Moayeri
Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages.
PloS one 2012;7(11):e49741.
2012: Jonathan L Levinsohn; Shihui Liu; Zachary L Newman; Inka Sastalla; Rasem Fattah; Matthew A Getz; Kristina A Hellmich; Stephen H Leppla; Mahtab Moayeri
Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.
PLoS pathogens 2012;8(3):e1002638.
2011: Clinton E Leysath; Mahtab Moayeri; Robert H Purcell; Kuang-Hua Chen; Zhaochun Chen; Devorah Crown; Suman Das; Rasem Fattah; Stephen H Leppla
Mouse monoclonal antibodies to anthrax edema factor protect against infection.
Infection and immunity 2011;79(11):4609-16.
2011: Andrei P Pomerantsev; Olga M Pomerantseva; Cynthia Tallant; Rasem Fattah; Mahtab Moayeri; Stephen H Leppla
A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins.
Protein expression and purification 2011;80(1):80-90.
2011: Zhaochun Chen; Mahtab Moayeri; Robert Purcell
Monoclonal antibody therapies against anthrax.
Toxins 2011;3(8):1004-19.
2011: Laith Altaweel; Zhaochun Chen; Mahtab Moayeri; Xizhong Cui; Yan Li; Junwu Su; Yvonne Fitz; Syd Johnson; Stephen H Leppla; Robert Purcell; Peter Q Eichacker
Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.
Critical care medicine 2011;39(6):1439-47.
2011: Seongjin Kim; Guan-Sheng Jiao; Mahtab Moayeri; Devorah Crown; Lynne Cregar-Hernandez; Linda McKasson; Stephen A Margosiak; Stephen H Leppla; Alan Johnson
Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy.
Bioorganic & medicinal chemistry letters 2011;21(7):2030-3.
2011: Caitlin W Hicks; Yan Li; Shu Okugawa; Steven B Solomon; Mahtab Moayeri; Stephen H Leppla; Ajana Mohanty; G. SUBRAMANIAN; Thi S Mignone; Yvonne Fitz; Xizhong Cui; Peter Q Eichacker
Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.
American journal of physiology. Heart and circulatory physiology 2011;300(3):H1108-18.
2011: Zachary L Newman; Nicole Sirianni; Christina Mawhinney; Margaret S Lee; Stephen H Leppla; Mahtab Moayeri; Lisa M Johansen
Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome.
Antimicrobial agents and chemotherapy 2011;55(3):1028-35.
2010: Shihui Liu; Sharmina Miller-Randolph; Devorah Crown; Mahtab Moayeri; Inka Sastalla; Shu Okugawa; Stephen H Leppla
Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.
Cell host & microbe 2010;8(5):455-62.
2010: Guan-Sheng Jiao; Seongjin Kim; Mahtab Moayeri; Lynne Cregar-Hernandez; Linda McKasson; Stephen A Margosiak; Stephen H Leppla; Alan Johnson
Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.
Bioorganic & medicinal chemistry letters 2010;20(22):6850-3.
2010: Zachary L Newman; Devorah Crown; Stephen H Leppla; Mahtab Moayeri
Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages.
Biochemical and biophysical research communications 2010;398(4):785-9.
2010: Zachary L Newman; Morton P Printz; Shihui Liu; Devorah Crown; Laura Breen; Sharmina Miller-Randolph; Pamela Flodman; Stephen H Leppla; Mahtab Moayeri
Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.
PLoS pathogens 2010;6(5):e1000906.
2010: Mahtab Moayeri; Devorah Crown; Zachary L Newman; Shu Okugawa; Michael Eckhaus; Christophe Cataisson; Shihui Liu; Inka Sastalla; Stephen H Leppla
Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.
PLoS pathogens 2010;6(12):e1001222.
2009: Mahtab Moayeri; Stephen H Leppla
Cellular and systemic effects of anthrax lethal toxin and edema toxin.
Molecular aspects of medicine 2009;30(6):439-55.
2009: Zachary L Newman; Stephen H Leppla; Mahtab Moayeri
CA-074Me protection against anthrax lethal toxin.
Infection and immunity 2009;77(10):4327-36.
2009: Zhaochun Chen; Mahtab Moayeri; Devorah Crown; Suzanne Emerson; Inna Gorshkova; Peter Schuck; Stephen H Leppla; Robert Purcell
Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody.
Infection and immunity 2009;77(9):3902-8.
2009: Zhaochun Chen; Mahtab Moayeri; Huaying Zhao; Devorah Crown; Stephen H Leppla; Robert Purcell
Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13487-92.
2009: Shihui Liu; Devorah Crown; Sharmina Miller-Randolph; Mahtab Moayeri; Hailun Wang; Haijing Hu; Thomas Morley; Stephen H Leppla
Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12424-9.
2009: Mahtab Moayeri; Devorah Crown; David W Dorward; Don Gardner; Jerrold M Ward; Yan Li; Xizhong Cui; Peter Eichacker; Stephen H Leppla
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).
PLoS pathogens 2009;5(5):e1000456.
2009: Yan Li; Xizhong Cui; Junwu Su; Michael Haley; Heather Macarthur; Kevin Sherer; Mahtab Moayeri; Stephen H Leppla; Yvonne Fitz; Peter Q Eichacker
Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats.
Critical care medicine 2009;37(4):1348-54.
2009: Shixing Tang; Mahtab Moayeri; Zhaochun Chen; Harri Harma; Jiangqin Zhao; Haijing Hu; Robert Purcell; Stephen H Leppla; Indira K Hewlett
Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles.
Clinical and vaccine immunology : CVI 2009;16(3):408-13.
2008: Christian J Kastrup; James Q Boedicker; Andrei P Pomerantsev; Mahtab Moayeri; Yao Bian; Rebecca R Pompano; Timothy R Kline; Patricia Sylvestre; Feng Shen; Stephen H Leppla; Wei-Jen Tang; Wenbin Du
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'.
Nature chemical biology 2008;4(12):742-50.
2008: Tera C Levin; Katherine E Wickliffe; Stephen H Leppla; Mahtab Moayeri
Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin.
Cellular microbiology 2008;10(12):2434-46.
2008: Mahtab Moayeri; Tanisha M Robinson; Stephen H Leppla; Vladimir A Karginov
In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin.
Antimicrobial agents and chemotherapy 2008;52(6):2239-41.
2008: Katherine E Wickliffe; Stephen H Leppla; Mahtab Moayeri
Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway.
Cellular microbiology 2008;10(6):1352-62.
2008: Katherine E Wickliffe; Stephen H Leppla; Mahtab Moayeri
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome.
Cellular microbiology 2008;10(2):332-43.
2008: Shihui Liu; Hailun Wang; Brooke M Currie; Alfredo A Molinolo; Howard J Leung; Mahtab Moayeri; John Basile; Randall W Alfano; J Silvio Gutkind; Arthur E Frankel; Thomas H Bugge; Stephen H Leppla
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature.
The Journal of biological chemistry 2008;283(1):529-40.
2008: Pradeep K Gupta; Mahtab Moayeri; Devorah Crown; Rasem J Fattah; Stephen H Leppla
Role of N-terminal amino acids in the potency of anthrax lethal factor.
PloS one 2008;3(9):e3130.
2007: Mahtab Moayeri; Jason F Wiggins; Stephen H Leppla
Anthrax protective antigen cleavage and clearance from the blood of mice and rats.
Infection and immunity 2007;75(11):5175-84.
2007: Kevin Sherer; Yan Li; Xizhong Cui; Xuemei Li; G. SUBRAMANIAN; Michael W Laird; Mahtab Moayeri; Stephen H Leppla; Yvonne Fitz; Junwu Su; Peter Q Eichacker
Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model.
Critical care medicine 2007;35(6):1560-7.
2007: Aaron M Firoved; Mahtab Moayeri; Jason F Wiggins; Yuequan Shen; Wei-Jen Tang; Stephen H Leppla
Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin.
Infection and immunity 2007;75(5):2120-5.
2007: Xizhong Cui; Yan Li; Xuemei Li; Michael W Laird; G. SUBRAMANIAN; Mahtab Moayeri; Stephen H Leppla; Yvonne Fitz; Junwu Su; Kevin Sherer; Peter Q Eichacker
Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model.
The Journal of infectious diseases 2007;195(4):572-80.
2006: Mahtab Moayeri; Jason F Wiggins; Robin E Lindeman; Stephen H Leppla
Cisplatin inhibition of anthrax lethal toxin.
Antimicrobial agents and chemotherapy 2006;50(8):2658-65.
2006: Mahtab Moayeri; Katherine E Wickliffe; Jason F Wiggins; Stephen H Leppla
Oxidized ATP protection against anthrax lethal toxin.
Infection and immunity 2006;74(7):3707-14.
2006: Xizhong Cui; Yan Li; Xuemei Li; Michael Haley; Mahtab Moayeri; Yvonne Fitz; Stephen H Leppla; Peter Q Eichacker
Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival.
The Journal of infectious diseases 2006;193(6):829-40.
2006: Zhaochun Chen; Mahtab Moayeri; Yi-Hua Zhou; Stephen H Leppla; Suzanne Emerson; Andrew Sebrell; Fujuan Yu; Juraj Svitel; Peter Schuck; Marisa St Claire; Robert Purcell
Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen.
The Journal of infectious diseases 2006;193(5):625-33.
2006: Yehoshua Gozes; Mahtab Moayeri; Jason F Wiggins; Stephen H Leppla
Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice.
Infection and immunity 2006;74(2):1266-72.
2005: Vijay Koya; Mahtab Moayeri; Stephen H Leppla; Henry Daniell
Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge.
Infection and immunity 2005;73(12):8266-74.
2005: Aaron M Firoved; Georgina F Miller; Mahtab Moayeri; Rahul Kakkar; Yuequan Shen; Jason F Wiggins; Elizabeth McNally; Wei-Jen Tang; Stephen H Leppla
Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice.
The American journal of pathology 2005;167(5):1309-20.
2005: Vladimir A Karginov; Ekaterina M Nestorovich; Mahtab Moayeri; Stephen H Leppla; Sergey M Bezrukov
Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15075-80.
2005: Mahtab Moayeri; Jeanette Webster Marketon; Jason F Wiggins; Stephen H Leppla; Esther M Sternberg
Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin.
Infection and immunity 2005;73(7):4238-44.
2005: Xizhong Cui; Yan Li; Mahtab Moayeri; Gil H Choi; G. SUBRAMANIAN; Xuemei Li; Michael Haley; Yvonne Fitz; Jing Feng; Steven M Banks; Stephen H Leppla; Peter Q Eichacker
Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis.
The Journal of infectious diseases 2005;191(3):422-34.
2004: Mahtab Moayeri; Nathaniel W Martinez; Jason F Wiggins; Howard A Young; Stephen H Leppla
Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity.
Infection and immunity 2004;72(8):4439-47.
2004: Jeanette Webster Marketon; Mahtab Moayeri; Esther M Sternberg
Novel repression of the glucocorticoid receptor by anthrax lethal toxin.
Annals of the New York Academy of Sciences 2004;1024():9-23.
2004: Xizhong Cui; Mahtab Moayeri; Yan Li; Xuemei Li; Michael Haley; Yvonne Fitz; Rosaly Correa-Araujo; Steven M Banks; Stephen H Leppla; Peter Q Eichacker
Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(4):R699-709.
2004: Mahtab Moayeri; Stephen H Leppla
The roles of anthrax toxin in pathogenesis.
Current opinion in microbiology 2004;7(1):19-24.
2003: Mahtab Moayeri; Diana Haines; Howard A Young; Stephen H Leppla
Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice.
The Journal of clinical investigation 2003;112(5):670-82.
2003: Jeanette Webster Marketon; Leonardo H Tonelli; Mahtab Moayeri; S Stoney Simons; Stephen H Leppla; Esther M Sternberg
Anthrax lethal factor represses glucocorticoid and progesterone receptor activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5706-11.
2002: G. Chaudry; Mahtab Moayeri; Shihui Liu; Stephen H Leppla
Quickening the pace of anthrax research: three advances point towards possible therapies.
Trends in microbiology 2002;10(2):58-62.