Shahriar Mobashery

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TOP 3
Gooyit Major; Lee Mijoon; Hesek Dusan; Boggess Bill; Oliver Allen G; Fridman Rafael; Mobashery Shahriar; Chang Mayland
Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.
Forbes Christopher; Shi Qicun; Fisher Jed F; Lee Mijoon; Hesek Dusan; Llarrull Leticia I; Toth Marta; Gossing Michael; Fridman Rafael; Mobashery Shahriar
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
Chen Yu; Zhang Weilie; Shi Qicun; Hesek Dusan; Lee Mijoon; Mobashery Shahriar; Shoichet Brian K
Crystal structures of penicillin-binding protein 6 from Escherichia coli.

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All Publications

2009: Gooyit Major; Lee Mijoon; Hesek Dusan; Boggess Bill; Oliver Allen G; Fridman Rafael; Mobashery Shahriar; Chang Mayland
Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.
Chemical biology & drug design 2009;74(6):535-46.
2009: Forbes Christopher; Shi Qicun; Fisher Jed F; Lee Mijoon; Hesek Dusan; Llarrull Leticia I; Toth Marta; Gossing Michael; Fridman Rafael; Mobashery Shahriar
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
Chemical biology & drug design 2009;74(6):527-34.
2009: Chen Yu; Zhang Weilie; Shi Qicun; Hesek Dusan; Lee Mijoon; Mobashery Shahriar; Shoichet Brian K
Crystal structures of penicillin-binding protein 6 from Escherichia coli.
Journal of the American Chemical Society 2009;131(40):14345-54.
2009: Tao Peng; Fisher Jed F; Shi Qicun; Vreven Thom; Mobashery Shahriar; Schlegel H Bernhard
Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue.
Biochemistry 2009;48(41):9839-47.
2009: Frase Hilary; Shi Qicun; Testero Sebastian A; Mobashery Shahriar; Vakulenko Sergei B
Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases.
The Journal of biological chemistry 2009;284(43):29509-13.
2009: Zhang Weilie; Fisher Jed F; Mobashery Shahriar
The bifunctional enzymes of antibiotic resistance.
Current opinion in microbiology 2009;12(5):505-11.
2009: Fisher Jed F; Mobashery Shahriar
Three decades of the class A beta-lactamase acyl-enzyme.
Current protein & peptide science 2009;10(5):401-7.
2009: Llarrull Leticia I; Fisher Jed F; Mobashery Shahriar
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.
Antimicrobial agents and chemotherapy 2009;53(10):4051-63.
2009: Ota Ryo; Kurihara Chie; Tsou Tsung-Ling; Young William L; Yeghiazarians Yerem; Chang Mayland; Mobashery Shahriar; Sakamoto Atsuhiro; Hashimoto Tomoki
Roles of matrix metalloproteinases in flow-induced outward vascular remodeling.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(9):1547-58.
2009: Lee Mijoon; Zhang Weilie; Hesek Dusan; Noll Bruce C; Boggess Bill; Mobashery Shahriar
Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance.
Journal of the American Chemical Society 2009;131(25):8742-3.
2009: Testero Sebastian A; O'Daniel Peter I; Shi Qicun; Lee Mijoon; Hesek Dusan; Ishiwata Akihiro; Noll Bruce C; Mobashery Shahriar
Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases.
Organic letters 2009;11(12):2515-8.
2009: Tao Peng; Fisher Jed F; Mobashery Shahriar; Schlegel H Bernhard
DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2.
Organic letters 2009;11(12):2559-62.
2009: Hesek Dusan; Lee Mijoon; Zhang Weilie; Noll Bruce C; Mobashery Shahriar
Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli.
Journal of the American Chemical Society 2009;131(14):5187-93.
2009: Hesek Dusan; Lee Mijoon; Noll Bruce C; Fisher Jed F; Mobashery Shahriar
Complications from dual roles of sodium hydride as a base and as a reducing agent.
The Journal of organic chemistry 2009;74(6):2567-70.
2009: Molina Rafael; González Ana; Stelter Meike; Pérez-Dorado Inmaculada; Kahn Richard; Morales María; Moscoso Miriam; Campuzano Susana; Campillo Nuria E; Mobashery Shahriar; García José L; García Pedro; Hermoso Juan A
Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae.
EMBO reports 2009;10(3):246-51.
2009: Toth Marta; Chow Joseph W; Mobashery Shahriar; Vakulenko Sergei B
Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.
The Journal of biological chemistry 2009;284(11):6690-6.
2009: Lee Mijoon; Celenza Giuseppe; Boggess Bill; Blase Jennifer; Shi Qicun; Toth Marta; Bernardo M Margarida; Wolter William R; Suckow Mark A; Hesek Dusan; Noll Bruce C; Fridman Rafael; Mobashery Shahriar; Chang Mayland
A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.
Chemical biology & drug design 2009;73(2):189-202.
2008: Zhao Huiren; Sohail Anjum; Sun Qing; Shi Qicun; Kim Seaho; Mobashery Shahriar; Fridman Rafael
Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25).
The Journal of biological chemistry 2008;283(50):35023-32.
2008: Suvorov Maxim; Lee Mijoon; Hesek Dusan; Boggess Bill; Mobashery Shahriar
Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall.
Journal of the American Chemical Society 2008;130(36):11878-9.
2008: Hesek Dusan; Lee Mijoon; Yamaguchi Takao; Noll Bruce C; Mobashery Shahriar
Facile preparation of a highly functionalized tetrahydropyran by catalytic hydrogenation of an oxazoline.
The Journal of organic chemistry 2008;73(18):7349-52.
2008: Bonfil R D; Fridman R; Mobashery S; Cher M L
Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis?
Current oncology (Toronto, Ont.) 2008;15(4):188-92.
2008: Martin Michelle D; Carter Kathy J; Jean-Philippe Sharon R; Chang Mayland; Mobashery Shahriar; Thiolloy Sophie; Lynch Conor C; Matrisian Lynn M; Fingleton Barbara
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.
Cancer research 2008;68(15):6251-9.
2008: Villegas-Estrada Adriel; Lee Mijoon; Hesek Dusan; Vakulenko Sergei B; Mobashery Shahriar
Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics.
Journal of the American Chemical Society 2008;130(29):9212-3.
2008: Shi Qicun; Meroueh Samy O; Fisher Jed F; Mobashery Shahriar
Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations.
Journal of the American Chemical Society 2008;130(29):9293-303.
2008: Lemaire Sandrine; Fuda Cosimo; Van Bambeke Françoise; Tulkens Paul M; Mobashery Shahriar
Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a.
The Journal of biological chemistry 2008;283(19):12769-76.
2008: Lee Mijoon; Hesek Dusan; Shi Qicun; Noll Bruce C; Fisher Jed F; Chang Mayland; Mobashery Shahriar
Conformational analyses of thiirane-based gelatinase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(10):3064-7.
2008: Totir Monica A; Cha Jooyoung; Ishiwata Akihiro; Wang Benlian; Sheri Anjaneyulu; Anderson Vernon E; Buynak John; Mobashery Shahriar; Carey Paul R
Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence.
Biochemistry 2008;47(13):4094-101.
2008: Celenza Giuseppe; Villegas-Estrada Adriel; Lee Mijoon; Boggess Bill; Forbes Christopher; Wolter William R; Suckow Mark A; Mobashery Shahriar; Chang Mayland
Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor.
Chemical biology & drug design 2008;71(3):187-96.
2008: Badarau Adriana; Shi Qicun; Chow Joseph W; Zajicek Jaroslav; Mobashery Shahriar; Vakulenko Sergei
Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus.
The Journal of biological chemistry 2008;283(12):7638-47.
2008: Kim Dae-Hee; Lilliehook Christina; Roides Breana; Chen Zhuoxun; Chang Mayland; Mobashery Shahriar; Goldman Steven A
Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(1):208-16.
2007: Rosenblum Gabriel; Meroueh Samy; Toth Marta; Fisher Jed F; Fridman Rafael; Mobashery Shahriar; Sagi Irit
Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma.
Journal of the American Chemical Society 2007;129(44):13566-74.
2007: Lee Mijoon; Villegas-Estrada Adriel; Celenza Giuseppe; Boggess Bill; Toth Marta; Kreitinger Gloria; Forbes Christopher; Fridman Rafael; Mobashery Shahriar; Chang Mayland
Metabolism of a highly selective gelatinase inhibitor generates active metabolite.
Chemical biology & drug design 2007;70(5):371-82.
2007: Brickner Steven J; Mobashery Shahriar
Prospects of therapies targeting resistant bacteria-New challenges 20 years post emergence of vancomycin-resistant enterococcus.
Current opinion in microbiology 2007;10(5):425-7.
2007: Zhang Weilie; Shi Qicun; Meroueh Samy O; Vakulenko Sergei B; Mobashery Shahriar
Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli.
Biochemistry 2007;46(35):10113-21.
2007: Pérez-Dorado Inmaculada; Campillo Nuria E; Monterroso Begoña; Hesek Dusan; Lee Mijoon; Páez Juan A; García Pedro; Martínez-Ripoll Martín; García José L; Mobashery Shahriar; Menéndez Margarita; Hermoso Juan A
Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1.
The Journal of biological chemistry 2007;282(34):24990-9.
2007: Suvorov Maxim; Vakulenko Sergei B; Mobashery Shahriar
Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance.
Antimicrobial agents and chemotherapy 2007;51(8):2937-42.
2007: Kling Dale; Hesek Dusan; Shi Qicun; Mobashery Shahriar
Design and synthesis of a structurally constrained aminoglycoside.
The Journal of organic chemistry 2007;72(14):5450-3.
2007: Fuda Cosimo; Suvorov Maxim; Shi Qicun; Hesek Dusan; Lee Mijoon; Mobashery Shahriar
Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.
Biochemistry 2007;46(27):8050-7.
2007: Cha Jooyoung; Vakulenko Sergei B; Mobashery Shahriar
Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus.
Biochemistry 2007;46(26):7822-31.
2007: Bonfil R Daniel; Dong Zhong; Trindade Filho J Carlos; Sabbota Aaron; Osenkowski Pamela; Nabha Sanaa; Yamamoto Hamilto; Chinni Sreenivasa R; Zhao Huiren; Mobashery Shahriar; Vessella Robert L; Fridman Rafael; Cher Michael L
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.
The American journal of pathology 2007;170(6):2100-11.
2007: Meroueh Samy O; Mobashery Shahriar
Conformational transition in the aminoacyl t-RNA site of the bacterial ribosome both in the presence and absence of an aminoglycoside antibiotic.
Chemical biology & drug design 2007;69(5):291-7.
2007: Cho Sangwoo; Wang Qian; Swaminathan Chittoor P; Hesek Dusan; Lee Mijoon; Boons Geert-Jan; Mobashery Shahriar; Mariuzza Roy A
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8761-6.
2007: Toth Marta; Zajicek Jaroslav; Kim Choonkeun; Chow Joseph W; Smith Clyde; Mobashery Shahriar; Vakulenko Sergei
Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib.
Biochemistry 2007;46(18):5570-8.
2007: Kim Choonkeun; Villegas-Estrada Adriel; Hesek Dusan; Mobashery Shahriar
Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa.
Biochemistry 2007;46(17):5270-82.
2007: Cha Jooyoung; Mobashery Shahriar
Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor.
Journal of the American Chemical Society 2007;129(13):3834-5.
2007: Rosenberg Gary A; Estrada Eduardo Y; Mobashery Shahriar
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents.
Brain research 2007;1133(1):186-92.
2006: Toth Marta; Sohail Anjum; Mobashery Shahriar; Fridman Rafael
MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts.
Biochemical and biophysical research communications 2006;350(2):377-84.
2006: Hesek Dusan; Toth Marta; Krchnak Viktor; Fridman Rafael; Mobashery Shahriar
Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease.
The Journal of organic chemistry 2006;71(16):5848-54.
2006: Kim Choonkeun; Hesek Dusan; Zajícek Jaroslav; Vakulenko Sergei B; Mobashery Shahriar
Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens.
Biochemistry 2006;45(27):8368-77.
2006: Thumanu Kanjana; Cha Jooyoung; Fisher Jed F; Perrins Richard; Mobashery Shahriar; Wharton Christopher
Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10630-5.
2006: Rekharsky Mikhail; Hesek Dusan; Lee Mijoon; Meroueh Samy O; Inoue Yoshihisa; Mobashery Shahriar
Thermodynamics of interactions of vancomycin and synthetic surrogates of bacterial cell wall.
Journal of the American Chemical Society 2006;128(24):7736-7.
2006: Bonfil R Daniel; Sabbota Aaron; Nabha Sanaa; Bernardo M Margarida; Dong Zhong; Meng Hong; Yamamoto Hamilto; Chinni Sreenivasa R; Lim Int Taek; Chang Mayland; Filetti Lusia C; Mobashery Shahriar; Cher Michael L; Fridman Rafael
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor.
International journal of cancer. Journal international du cancer 2006;118(11):2721-6.
2006: Hesek Dusan; Toth Marta; Meroueh Samy O; Brown Stephen; Zhao Huiren; Sakr Wael; Fridman Rafael; Mobashery Shahriar
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples.
Chemistry & biology 2006;13(4):379-86.
2006: Fuda Cosimo; Hesek Dusan; Lee Mijoon; Heilmayer Werner; Novak Rodger; Vakulenko Sergei B; Mobashery Shahriar
Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus.
The Journal of biological chemistry 2006;281(15):10035-41.
2006: Fisher Jed F; Mobashery Shahriar
Recent advances in MMP inhibitor design.
Cancer metastasis reviews 2006;25(1):115-36.
2006: Hesek Dusan; Noll Bruce C; Mobashery Shahriar
Side reaction of significance in preparation of peptide- or peptidomimetic-based hydroxamate enzyme inhibitors.
The Journal of organic chemistry 2006;71(7):2885-7.
2006: Meroueh Samy O; Bencze Krisztina Z; Hesek Dusan; Lee Mijoon; Fisher Jed F; Stemmler Timothy L; Mobashery Shahriar
Three-dimensional structure of the bacterial cell wall peptidoglycan.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4404-9.
2006: Kim Choonkeun; Cha Joo Young; Yan Honggao; Vakulenko Sergei B; Mobashery Shahriar
Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme.
The Journal of biological chemistry 2006;281(11):6964-9.
2006: Murray James B; Meroueh Samy O; Russell Rupert J M; Lentzen Georg; Haddad Jalal; Mobashery Shahriar
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site.
Chemistry & biology 2006;13(2):129-38.
2005: Meroueh Samy O; Fisher Jed F; Schlegel H Bernhard; Mobashery Shahriar
Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70.
Journal of the American Chemical Society 2005;127(44):15397-407.
2005: Fuda C C S; Fisher J F; Mobashery S
Beta-lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome.
Cellular and molecular life sciences : CMLS 2005;62(22):2617-33.
2005: Li Jie; Cross Jason B; Vreven Thom; Meroueh Samy O; Mobashery Shahriar; Schlegel H Bernhard
Lysine carboxylation in proteins: OXA-10 beta-lactamase.
Proteins 2005;61(2):246-57.
2005: Ikejiri Masahiro; Bernardo M Margarida; Bonfil R Daniel; Toth Marta; Chang Mayland; Fridman Rafael; Mobashery Shahriar
Potent mechanism-based inhibitors for matrix metalloproteinases.
The Journal of biological chemistry 2005;280(40):33992-4002.
2005: Lee Mijoon; Bernardo M Margarida; Meroueh Samy O; Brown Stephen; Fridman Rafael; Mobashery Shahriar
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.
Organic letters 2005;7(20):4463-5.
2005: Gu Zezong; Cui Jiankun; Brown Stephen; Fridman Rafael; Mobashery Shahriar; Strongin Alex Y; Lipton Stuart A
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(27):6401-8.
2005: Ikejiri Masahiro; Bernardo M Margarida; Meroueh Samy O; Brown Stephen; Chang Mayland; Fridman Rafael; Mobashery Shahriar
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.
The Journal of organic chemistry 2005;70(14):5709-12.
2005: Thomas Veena L; Golemi-Kotra Dasantila; Kim Choonkeun; Vakulenko Sergei B; Mobashery Shahriar; Shoichet Brian K
Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.
Biochemistry 2005;44(26):9330-8.
2005: Osenkowski Pamela; Meroueh Samy O; Pavel Dumitru; Mobashery Shahriar; Fridman Rafael
Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing.
The Journal of biological chemistry 2005;280(28):26160-8.
2005: Kim Choonkeun; Mobashery Shahriar
Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance.
Bioorganic chemistry 2005;33(3):149-58.
2005: Krüger Achim; Arlt Matthias J E; Gerg Michael; Kopitz Charlotte; Bernardo M Margarida; Chang Mayland; Mobashery Shahriar; Fridman Rafael
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.
Cancer research 2005;65(9):3523-6.
2005: Toth Marta; Osenkowski Pamela; Hesek Dusan; Brown Stephen; Meroueh Samy; Sakr Wael; Mobashery Shahriar; Fridman Rafael
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase.
The Biochemical journal 2005;387(Pt 2):497-506.
2005: Cross Jason B; Vreven Thom; Meroueh Samy O; Mobashery Shahriar; Schlegel H Bernhard
Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A.
The journal of physical chemistry. B 2005;109(10):4761-9.
2005: Fuda Cosimo; Hesek Dusan; Lee Mijoon; Morio Ken-ichiro; Nowak Thomas; Mobashery Shahriar
Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall.
Journal of the American Chemical Society 2005;127(7):2056-7.
2005: Fisher Jed F; Meroueh Samy O; Mobashery Shahriar
Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity.
Chemical reviews 2005;105(2):395-424.
2005: Lee Mijoon; Hesek Dusan; Mobashery Shahriar
A practical synthesis of nitrocefin.
The Journal of organic chemistry 2005;70(1):367-9.
2004: Birck Catherine; Cha Joo Young; Cross Jason; Schulze-Briese Clemens; Meroueh Samy O; Schlegel H Bernhard; Mobashery Shahriar; Samama Jean-Pierre
X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction.
Journal of the American Chemical Society 2004;126(43):13945-7.
2004: Lee Mijoon; Fridman Rafael; Mobashery Shahriar
Extracellular proteases as targets for treatment of cancer metastases.
Chemical Society reviews 2004;33(7):401-9.
2004: Fuda Cosimo; Suvorov Maxim; Vakulenko Sergei B; Mobashery Shahriar
The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.
The Journal of biological chemistry 2004;279(39):40802-6.
2004: Lim In Taek; Meroueh Samy O; Lee Mijoon; Heeg Mary Jane; Mobashery Shahriar
Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis.
Journal of the American Chemical Society 2004;126(33):10271-7.
2004: Golemi-Kotra Dasantila; Meroueh Samy O; Kim Choonkeun; Vakulenko Sergei B; Bulychev Alexey; Stemmler Ann J; Stemmler Timothy L; Mobashery Shahriar
The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins.
The Journal of biological chemistry 2004;279(33):34665-73.
2004: Solomon Ariel; Rosenblum Gabriel; Gonzales Patricia E; Leonard Jennifer D; Mobashery Shahriar; Milla Marcos E; Sagi Irit
Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity.
The Journal of biological chemistry 2004;279(30):31646-54.
2004: Lim In Taek; Brown Stephen; Mobashery Shahriar
A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent.
The Journal of organic chemistry 2004;69(10):3572-3.
2004: Cha Joo Young; Ishiwata Akihiro; Mobashery Shahriar
A novel beta-lactamase activity from a penicillin-binding protein of Treponema pallidum and why syphilis is still treatable with penicillin.
The Journal of biological chemistry 2004;279(15):14917-21.
2004: Hesek Dusan; Lee Mijoon; Morio Ken-ichiro; Mobashery Shahriar
Synthesis of a fragment of bacterial cell wall.
The Journal of organic chemistry 2004;69(6):2137-46.
2004: Kim Choonkeun; Haddad Jalal; Vakulenko Sergei B; Meroueh Samy O; Wu Yan; Yan Honggao; Mobashery Shahriar
Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria.
Biochemistry 2004;43(9):2373-83.
2004: Hesek Dusan; Suvorov Maxim; Morio Ken-Ichiro; Lee Mijoon; Brown Stephen; Vakulenko Sergei B; Mobashery Shahriar
Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria.
The Journal of organic chemistry 2004;69(3):778-84.
2004: Brown Stephen; Meroueh Samy O; Fridman Rafael; Mobashery Shahriar
Quest for selectivity in inhibition of matrix metalloproteinases.
Current topics in medicinal chemistry 2004;4(12):1227-38.
2003: Lee Mijoon; Hesek Dusan; Suvorov Maxim; Lee Wenlin; Vakulenko Sergei; Mobashery Shahriar
A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins.
Journal of the American Chemical Society 2003;125(52):16322-6.
2003: Richard John P; Mobashery Shahriar
Complex biological processes and their central chemical events.
Current opinion in chemical biology 2003;7(5):525-7.
2003: Meroueh Samy O; Minasov George; Lee Wenlin; Shoichet Brian K; Mobashery Shahriar
Structural aspects for evolution of beta-lactamases from penicillin-binding proteins.
Journal of the American Chemical Society 2003;125(32):9612-8.
2003: Vakulenko Sergei B; Mobashery Shahriar
Versatility of aminoglycosides and prospects for their future.
Clinical microbiology reviews 2003;16(3):430-50.
2003: Rosenblum Gabriel; Meroueh Samy O; Kleifeld Oded; Brown Stephen; Singson Steven P; Fridman Rafael; Mobashery Shahriar; Sagi Irit
Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2).
The Journal of biological chemistry 2003;278(29):27009-15.
2003: Fridman Rafael; Toth Marta; Chvyrkova Irina; Meroueh Samy O; Mobashery Shahriar
Cell surface association of matrix metalloproteinase-9 (gelatinase B).
Cancer metastasis reviews 2003;22(2-3):153-66.
2003: Golemi-Kotra Dasantila; Cha Joo Young; Meroueh Samy O; Vakulenko Sergei B; Mobashery Shahriar
Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus.
The Journal of biological chemistry 2003;278(20):18419-25.
2003: Russell Rupert J M; Murray James B; Lentzen Georg; Haddad Jalal; Mobashery Shahriar
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography.
Journal of the American Chemical Society 2003;125(12):3410-1.
2003: Wilkinson Alan-Shaun; Bryant Patrick K; Meroueh Samy O; Page Malcolm G P; Mobashery Shahriar; Wharton Christopher W
A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations.
Biochemistry 2003;42(7):1950-7.
2002: Kotra Lakshmi P; Zhang Li; Fridman Rafael; Orlando Ron; Mobashery Shahriar
N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9.
Bioorganic chemistry 2002;30(5):356-70.
2002: Meroueh Samy O; Roblin Pierre; Golemi Dasantila; Maveyraud Laurent; Vakulenko Sergei B; Zhang Yun; Samama Jean-Pierre; Mobashery Shahriar
Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli.
Journal of the American Chemical Society 2002;124(32):9422-30.
2002: Toth Marta; Hernandez-Barrantes Sonia; Osenkowski Pamela; Bernardo M Margarida; Gervasi David C; Shimura Yoichiro; Meroueh Oussama; Kotra Lakshmi P; Gálvez Beatriz G; Arroyo Alicia G; Mobashery Shahriar; Fridman Rafael
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme.
The Journal of biological chemistry 2002;277(29):26340-50.
2002: Vakulenko Sergei B; Golemi Dasantila; Geryk Bruce; Suvorov Maxim; Knox James R; Mobashery Shahriar; Lerner Stephen A
Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime.
Antimicrobial agents and chemotherapy 2002;46(6):1966-70.
2002: Llano-Sotelo Beatriz; Azucena Eduardo F; Kotra Lakshmi P; Mobashery Shahriar; Chow Christine S
Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site.
Chemistry & biology 2002;9(4):455-63.
2002: Haddad Jalal; Kotra Lakshmi P; Llano-Sotelo Beatriz; Kim Choonkeun; Azucena Eduardo F; Liu Meizheng; Vakulenko Sergei B; Chow Christine S; Mobashery Shahriar
Design of novel antibiotics that bind to the ribosomal acyltransfer site.
Journal of the American Chemical Society 2002;124(13):3229-37.
2002: Maveyraud Laurent; Golemi-Kotra Dasantila; Ishiwata Akihiro; Meroueh Oussama; Mobashery Shahriar; Samama Jean-Pierre
High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase.
Journal of the American Chemical Society 2002;124(11):2461-5.
2002: Bernardo M Margarida; Brown Stephen; Li Zhi-Hong; Fridman Rafael; Mobashery Shahriar
Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases.
The Journal of biological chemistry 2002;277(13):11201-7.
2001: Golemi D; Maveyraud L; Vakulenko S; Samama J P; Mobashery S
Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14280-5.
2001: Grapsas I; Lerner S A; Mobashery S
Conjoint molecules of cephalosporins and aminoglycosides.
Archiv der Pharmazie 2001;334(8-9):295-301.
2001: Petty H R; Fernando M; Kindzelskii A L; Zarewych B N; Ksebati M B; Hryhorczuk L M; Mobashery S
Identification of colchicine in placental blood from patients using herbal medicines.
Chemical research in toxicology 2001;14(9):1254-8.
2001: Kim D H; Mobashery S
Mechanism-based inhibition of zinc proteases.
Current medicinal chemistry 2001;8(8):959-65.
2001: Nagase T; Golemi D; Ishiwata A; Mobashery S
Inhibition of beta-lactamases by 6,6-bis(hydroxylmethyl)penicillanate.
Bioorganic chemistry 2001;29(3):140-5.
2001: Kridel S J; Chen E; Kotra L P; Howard E W; Mobashery S; Smith J W
Substrate hydrolysis by matrix metalloproteinase-9.
The Journal of biological chemistry 2001;276(23):20572-8.
2001: Kleifeld O; Kotra L P; Gervasi D C; Brown S; Bernardo M M; Fridman R; Mobashery S; Sagi I
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme.
The Journal of biological chemistry 2001;276(20):17125-31.
2001: Azucena E; Mobashery S
Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001;4(2):106-17.
2001: Kotra L P; Cross J B; Shimura Y; Fridman R; Schlegel H B; Mobashery S
Insight into the complex and dynamic process of activation of matrix metalloproteinases.
Journal of the American Chemical Society 2001;123(13):3108-13.
2001: Lee W; McDonough M A; Kotra L; Li Z H; Silvaggi N R; Takeda Y; Kelly J A; Mobashery S
A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1427-31.
2000: Maveyraud L; Golemi D; Kotra L P; Tranier S; Vakulenko S; Mobashery S; Samama J P
Insights into class D beta-lactamases are revealed by the crystal structure of the OXA10 enzyme from Pseudomonas aeruginosa.
Structure (London, England : 1993) 2000;8(12):1289-98.
2000: Kotra L P; Haddad J; Mobashery S
Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.
Antimicrobial agents and chemotherapy 2000;44(12):3249-56.
2000: Toth M; Bernardo M M; Gervasi D C; Soloway P D; Wang Z; Bigg H F; Overall C M; DeClerck Y A; Tschesche H; Cher M L; Brown S; Mobashery S; Fridman R
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
The Journal of biological chemistry 2000;275(52):41415-23.
2000: Liu M; Haddad J; Azucena E; Kotra L P; Kirzhner M; Mobashery S
Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3'-phosphotransferases.
The Journal of organic chemistry 2000;65(22):7422-31.
2000: Golemi D; Maveyraud L; Ishiwata A; Tranier S; Miyashita K; Nagase T; Massova I; Mourey L; Samama J P; Mobashery S
6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases.
The Journal of antibiotics 2000;53(10):1022-7.
2000: Ishiwata A; Kotra L P; Miyashita K; Nagase T; Mobashery S
Stereoselective reduction of alpha-bromopenicillanates by tributylphosphine.
Organic letters 2000;2(18):2889-92.
2000: Kotra L P; Vakulenko S; Mobashery S
From genes to sequences to antibiotics: prospects for future developments from microbial genomics.
Microbes and infection / Institut Pasteur 2000;2(6):651-8.
2000: Therrien C; Kotra L P; Sanschagrin F; Mobashery S; Levesque R C
Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors.
FEBS letters 2000;470(3):285-92.
2000: Olson M W; Bernardo M M; Pietila M; Gervasi D C; Toth M; Kotra L P; Massova I; Mobashery S; Fridman R
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1.
The Journal of biological chemistry 2000;275(4):2661-8.
2000: Lee W; Li Z H; Vakulenko S; Mobashery S
A light-inactivated antibiotic.
Journal of medicinal chemistry 2000;43(1):128-32.
1999: Massova I; Mobashery S
Structural and mechanistic aspects of evolution of beta-lactamases and penicillin-binding proteins.
Current pharmaceutical design 1999;5(11):929-37.
1999: Mourey L; Kotra L P; Bellettini J; Bulychev A; O'Brien M; Miller M J; Mobashery S; Samama J P
Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic beta-lactams.
The Journal of biological chemistry 1999;274(36):25260-5.
1999: Vakulenko S B; Taibi-Tronche P; Tóth M; Massova I; Lerner S A; Mobashery S
Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli.
The Journal of biological chemistry 1999;274(33):23052-60.
1999: Swarén P; Golemi D; Cabantous S; Bulychev A; Maveyraud L; Mobashery S; Samama J P
X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid.
Biochemistry 1999;38(30):9570-6.
1999: Bulychev A; Mobashery S
Class C beta-lactamases operate at the diffusion limit for turnover of their preferred cephalosporin substrates.
Antimicrobial agents and chemotherapy 1999;43(7):1743-6.
1999: Kotra L P; Mobashery S
Mechanistic and clinical aspects of beta-lactam antibiotics and beta-lactamases.
Archivum immunologiae et therapiae experimentalis 1999;47(4):211-6.
1998: Yang Y; Roestamadji J; Mobashery S; Orlando R
The use of neamine as a molecular template: identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa by mass spectroscopy.
Bioorganic & medicinal chemistry letters 1998;8(24):3489-94.
1998: Roestamadji J; Mobashery S
The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa.
Bioorganic & medicinal chemistry letters 1998;8(24):3483-8.
1998: Massova I; Martin P; Bulychev A; Kocz R; Doyle M; Edwards B F; Mobashery S
Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin.
Bioorganic & medicinal chemistry letters 1998;8(18):2463-6.
1998: Massova I; Kotra L P; Fridman R; Mobashery S
Matrix metalloproteinases: structures, evolution, and diversification.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(12):1075-95.
1998: Vakulenko S B; Geryk B; Kotra L P; Mobashery S; Lerner S A
Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
Antimicrobial agents and chemotherapy 1998;42(7):1542-8.
1998: Massova I; Kotra L P; Mobashery S
Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases.
Bioorganic & medicinal chemistry letters 1998;8(7):853-8.
1998: Massova I; Mobashery S
Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases.
Antimicrobial agents and chemotherapy 1998;42(1):1-17.
1998: Bush K; Mobashery S
How beta-lactamases have driven pharmaceutical drug discovery. From mechanistic knowledge to clinical circumvention.
Advances in experimental medicine and biology 1998;456():71-98.
1998: Wright G D; Berghuis A M; Mobashery S
Aminoglycoside antibiotics. Structures, functions, and resistance.
Advances in experimental medicine and biology 1998;456():27-69.
1997: Olson M W; Gervasi D C; Mobashery S; Fridman R
Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2.
The Journal of biological chemistry 1997;272(47):29975-83.
1996: McKay G A; Roestamadji J; Mobashery S; Wright G D
Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups.
Antimicrobial agents and chemotherapy 1996;40(11):2648-50.
1996: Ghosh S S; Dakoji S; Tanaka Y; Cho Y J; Mobashery S
Properties of analogues of an intermediate in the process of mechanism-based inactivation of carboxypeptidase A.
Bioorganic & medicinal chemistry 1996;4(9):1487-92.
1995: Siregar J J; Miroshnikov K; Mobashery S
Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia.
Biochemistry 1995;34(39):12681-8.
1995: Vakulenko S B; Tóth M; Taibi P; Mobashery S; Lerner S A
Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams.
Antimicrobial agents and chemotherapy 1995;39(8):1878-80.
1995: Fridman R; Toth M; Peña D; Mobashery S
Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).
Cancer research 1995;55(12):2548-55.
1994: Imtiaz U; Billings E M; Knox J R; Mobashery S
A structure-based analysis of the inhibition of class A beta-lactamases by sulbactam.
Biochemistry 1994;33(19):5728-38.
1994: Imtiaz U; Manavathu E K; Mobashery S; Lerner S A
Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime.
Antimicrobial agents and chemotherapy 1994;38(5):1134-9.
1994: Siregar J J; Lerner S A; Mobashery S
Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme.
Antimicrobial agents and chemotherapy 1994;38(4):641-7.
1993: Imtiaz U; Manavathu E K; Lerner S A; Mobashery S
Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase.
Antimicrobial agents and chemotherapy 1993;37(11):2438-42.
1993: Levy O E; Taibi P; Mobashery S; Ghosh S S
A mechanism-based inactivation study of neutral endopeptidase 24.11.
Journal of medicinal chemistry 1993;36(16):2408-11.
1992: Ghosh S S; Said-Nejad O; Roestamadji J; Mobashery S
The first mechanism-based inactivators for angiotensin-converting enzyme.
Journal of medicinal chemistry 1992;35(22):4175-9.
1992: Zafaralla G; Manavathu E K; Lerner S A; Mobashery S
Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases.
Biochemistry 1992;31(15):3847-52.
1991: Wu Y Q; Mobashery S
Targeting renal dipeptidase (dehydropeptidase I) for inactivation by mechanism-based inactivators.
Journal of medicinal chemistry 1991;34(6):1914-6.
1991: Ghosh S S; Wu Y Q; Mobashery S
Peptidic mechanism-based inactivators for carboxypeptidase A.
The Journal of biological chemistry 1991;266(14):8759-64.
1990: Mobashery S; Doughty M; Kaiser E T
Inactivation of the catalytic subunit of bovine cAMP-dependent protein kinase by a peptide-based affinity inactivator.
Biopolymers 1990;29(1):131-8.
1990: Mobashery S; Ghosh S S; Tamura S Y; Kaiser E T
Design of an effective mechanism-based inactivator for a zinc protease.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):578-82.
1989: Radziejewski C; Miller W T; Mobashery S; Goldberg A R; Kaiser E T
Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference.
Biochemistry 1989;28(23):9047-52.
1988: Mobashery S; Lerner S A; Johnston M
Monitoring beta-lactamase activity in vivo by 13C nuclear magnetic resonance spectroscopy.
Antimicrobial agents and chemotherapy 1988;32(8):1196-203.
1988: Mobashery S; Kaiser E T
Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels.
Biochemistry 1988;27(10):3691-6.
1987: Mobashery S; Johnston M
Inactivation of alanine racemase by beta-chloro-L-alanine released enzymatically from amino acid and peptide C10-esters of deacetylcephalothin.
Biochemistry 1987;26(18):5878-84.
1986: Mobashery S; Johnston M
Reactions of Escherichia coli TEM beta-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters.
The Journal of biological chemistry 1986;261(17):7879-87.

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