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Edward Moczydlowski

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Chemicals & Drugs

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Publications

TOP 3
Yucheng Xiao; Jon-Paul Bingham; Weiguo Zhu; Edward Moczydlowski; Songping Liang; Theodore R Cummins
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
X Sun; Dan Zhou; P Zhang; Edward Moczydlowski; Gabriel G Haddad
Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid.
Edward Moczydlowski
The maxi K+ channel of human myometrium reveals a split personality.

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All Publications

2008: Yucheng Xiao; Jon-Paul Bingham; Weiguo Zhu; Edward Moczydlowski; Songping Liang; Theodore R Cummins
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
The Journal of biological chemistry 2008;283(40):27300-13.
2007: X Sun; Dan Zhou; P Zhang; Edward Moczydlowski; Gabriel G Haddad
Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid.
Journal of neurophysiology 2007;97(1):62-9.
2006: Edward Moczydlowski
The maxi K+ channel of human myometrium reveals a split personality.
The Journal of physiology 2006;573(Pt 2):286.
2006: Jon-Paul Bingham; Shumin Bian; Zhi-Yong Tan; Zoltan Takacs; Edward Moczydlowski
Synthesis of a biotin derivative of iberiotoxin: binding interactions with streptavidin and the BK Ca2+-activated K+ channel expressed in a human cell line.
Bioconjugate chemistry 2006;17(3):689-99.
2006: Robert M Douglas; J C K Lai; Shumin Bian; L Cummins; Edward Moczydlowski; Gabriel G Haddad
The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain.
Neuroscience 2006;139(4):1249-61.
2005: Manoj N Krishnan; Jon-Paul Bingham; Siew Hwee Lee; Patrick Trombley; Edward Moczydlowski
Functional role and affinity of inorganic cations in stabilizing the tetrameric structure of the KcsA K+ channel.
The Journal of general physiology 2005;126(3):271-83.
2005: Jon-Paul Bingham; Natalie M Broxton; Bruce G Livett; John Down; Alun Jones; Edward Moczydlowski
Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study.
Analytical biochemistry 2005;338(1):48-61.
2004: Sho-Ya Wang; Jane Mitchell; Edward Moczydlowski; Ging Kuo Wang
Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.
The Journal of general physiology 2004;124(6):691-701.
2004: Edward Moczydlowski
BK channel news: full coverage on the calcium bowl.
The Journal of general physiology 2004;123(5):471-3.
2004: Sho-Ya Wang; Edward Moczydlowski; G Wang
Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells.
Receptors & channels 2004;10(3-4):131-8.
2003: Jin Bong Park; Hee Jeong Kim; Pan Dong Ryu; Edward Moczydlowski
Effect of phosphatidylserine on unitary conductance and Ba2+ block of the BK Ca2+-activated K+ channel: re-examination of the surface charge hypothesis.
The Journal of general physiology 2003;121(5):375-97.
2001: Yan G Ni; Jie-Guang Chen; Andreas Androutsellis-Theotokis; C J Huang; Edward Moczydlowski; Gary Rudnick
A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109.
The Journal of biological chemistry 2001;276(33):30942-7.
2001: Shumin Bian; I Favre; Edward Moczydlowski
Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4776-81.
2001: C J Huang; Edward Moczydlowski
Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel.
Biophysical journal 2001;80(3):1262-79.
2001: G Krishnan; M A Morabito; Edward Moczydlowski
Expression and characterization of Flag-epitope- and hexahistidine-tagged derivatives of saxiphilin for use in detection and assay of saxitoxin.
Toxicon : official journal of the International Society on Toxinology 2001;39(2-3):291-301.
2000: Brigita Lenarcic; G Krishnan; R Borukhovich; B Ruck; Vito Turk; Edward Moczydlowski
Saxiphilin, a saxitoxin-binding protein with two thyroglobulin type 1 domains, is an inhibitor of papain-like cysteine proteinases.
The Journal of biological chemistry 2000;275(20):15572-7.
2000: C J Huang; I Favre; Edward Moczydlowski
Permeation of large tetra-alkylammonium cations through mutant and wild-type voltage-gated sodium channels as revealed by relief of block at high voltage.
The Journal of general physiology 2000;115(4):435-54.
2000: I Favre; G W Moss; D P Goldenberg; J Otlewski; Edward Moczydlowski
Structure-activity relationships for the interaction of bovine pancreatic trypsin inhibitor with an intracellular site on a large conductance Ca(2+)-activated K(+) channel.
Biochemistry 2000;39(8):2001-12.
1999: H Liu; Edward Moczydlowski; Gabriel G Haddad
O(2) deprivation inhibits Ca(2+)-activated K(+) channels via cytosolic factors in mice neocortical neurons.
The Journal of clinical investigation 1999;104(5):577-88.
1999: I Favre; Edward Moczydlowski
Simultaneous binding of basic peptides at intracellular sites on a large conductance Ca2+-activated K+ channel. Equilibrium and kinetic basis of negatively coupled ligand interactions.
The Journal of general physiology 1999;113(2):295-320.
1999: I Favre; Y M Sun; Edward Moczydlowski
Reconstitution of native and cloned channels into planar bilayers.
Methods in enzymology 1999;294():287-304.
1998: Edward Moczydlowski
Chemical basis for alkali cation selectivity in potassium-channel proteins.
Chemistry & biology 1998;5(11):R291-301.
1997: Y M Sun; I Favre; L Schild; Edward Moczydlowski
On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving.
The Journal of general physiology 1997;110(6):693-715.
1996: G W Moss; J Marshall; M Morabito; J R Howe; Edward Moczydlowski
An evolutionarily conserved binding site for serine proteinase inhibitors in large conductance calcium-activated potassium channels.
Biochemistry 1996;35(50):16024-35.
1996: G W Moss; J Marshall; Edward Moczydlowski
Hypothesis for a serine proteinase-like domain at the COOH terminus of Slowpoke calcium-activated potassium channels.
The Journal of general physiology 1996;108(6):473-84.
1996: I Favre; Edward Moczydlowski; Laurent Schild
On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel.
Biophysical journal 1996;71(6):3110-25.
1996: G W Moss; Edward Moczydlowski
Rectifying conductance substates in a large conductance Ca(2+)-activated K+ channel: evidence for a fluctuating barrier mechanism.
The Journal of general physiology 1996;107(1):47-68.
1995: M A Morabito; Lyndon E Llewellyn; Edward Moczydlowski
Expression of saxiphilin in insect cells and localization of the saxitoxin-binding site to the C-terminal domain homologous to the C-lobe of transferrins.
Biochemistry 1995;34(40):13027-33.
1995: I Favre; Edward Moczydlowski; Laurent Schild
Specificity for block by saxitoxin and divalent cations at a residue which determines sensitivity of sodium channel subtypes to guanidinium toxins.
The Journal of general physiology 1995;106(2):203-29.
1995: M A Morabito; Edward Moczydlowski
Molecular cloning of bullfrog saxiphilin: a unique relative of the transferrin family that binds saxitoxin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6651.
1994: Lyndon E Llewellyn; Edward Moczydlowski
Characterization of saxitoxin binding to saxiphilin, a relative of the transferrin family that displays pH-dependent ligand binding.
Biochemistry 1994;33(40):12312-22.
1994: M A Morabito; Edward Moczydlowski
Molecular cloning of bullfrog saxiphilin: a unique relative of the transferrin family that binds saxitoxin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2478-82.
1994: Laurent Schild; Edward Moczydlowski
Permeation of Na+ through open and Zn(2+)-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions in a multi-ion channel.
Biophysical journal 1994;66(3 Pt 1):654-66.
1993: Y Li; Lyndon E Llewellyn; Edward Moczydlowski
Biochemical and immunochemical comparison of saxiphilin and transferrin, two structurally related plasma proteins from Rana catesbeiana.
Molecular pharmacology 1993;44(4):742-8.
1993: Edward Moczydlowski
Profiles of permeation through Na-channels.
Biophysical journal 1993;64(4):1051-2.
1992: Arippa Ravindran; H Kwiecinski; Osvaldo Alvarez; G Eisenman; Edward Moczydlowski
Modeling ion permeation through batrachotoxin-modified Na+ channels from rat skeletal muscle with a multi-ion pore.
Biophysical journal 1992;61(2):494-508.
1992: Edward Moczydlowski; G W Moss; K J Lucchesi
Bovine pancreatic trypsin inhibitor as a probe of large conductance Ca(2+)-activated K+ channels at an internal site of interaction.
Biochemical pharmacology 1992;43(1):21-8.
1991: Y Li; Edward Moczydlowski
Purification and partial sequencing of saxiphilin, a saxitoxin-binding protein from the bullfrog, reveals homology to transferrin.
The Journal of biological chemistry 1991;266(23):15481-7.
1991: K J Lucchesi; Edward Moczydlowski
On the interaction of bovine pancreatic trypsin inhibitor with maxi Ca(2+)-activated K+ channels. A model system for analysis of peptide-induced subconductance states.
The Journal of general physiology 1991;97(6):1295-319.
1991: Laurent Schild; Edward Moczydlowski
Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site.
Biophysical journal 1991;59(3):523-37.
1991: J Mahar; G L Lukács; Y Li; S Hall; Edward Moczydlowski
Pharmacological and biochemical properties of saxiphilin, a soluble saxitoxin-binding protein from the bullfrog (Rana catesbeiana).
Toxicon : official journal of the International Society on Toxinology 1991;29(1):53-71.
1991: Arippa Ravindran; Laurent Schild; Edward Moczydlowski
Divalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels.
The Journal of general physiology 1991;97(1):89-115.
1991: Laurent Schild; Arippa Ravindran; Edward Moczydlowski
Zn2(+)-induced subconductance events in cardiac Na+ channels prolonged by batrachotoxin. Current-voltage behavior and single-channel kinetics.
The Journal of general physiology 1991;97(1):117-42.
1990: G L Lukács; Edward Moczydlowski
A chloride channel from lobster walking leg nerves. Characterization of single-channel properties in planar bilayers.
The Journal of general physiology 1990;96(4):707-33.
1990: K Lucchesi; Edward Moczydlowski
Subconductance behavior in a maxi Ca2(+)-activated K+ channel induced by dendrotoxin-I.
Neuron 1990;4(1):141-8.
1989: K Lucchesi; Arippa Ravindran; H Young; Edward Moczydlowski
Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-activated K+ channels.
The Journal of membrane biology 1989;109(3):269-81.
1989: Arippa Ravindran; Edward Moczydlowski
Influence of negative surface charge on toxin binding to canine heart Na channels in planar bilayers.
Biophysical journal 1989;55(2):359-65.
1988: Edward Moczydlowski; K Lucchesi; Arippa Ravindran
An emerging pharmacology of peptide toxins targeted against potassium channels.
The Journal of membrane biology 1988;105(2):95-111.
1988: Edward Moczydlowski; J Mahar; Arippa Ravindran
Multiple saxitoxin-binding sites in bullfrog muscle: tetrodotoxin-sensitive sodium channels and tetrodotoxin-insensitive sites of unknown function.
Molecular pharmacology 1988;33(2):202-11.
1987: X T Guo; A Uehara; Arippa Ravindran; S H Bryant; S Hall; Edward Moczydlowski
Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle.
Biochemistry 1987;26(24):7546-56.
1985: Edward Moczydlowski; Osvaldo Alvarez; Cecilia Vergara; Ramon Latorre
Effect of phospholipid surface charge on the conductance and gating of a Ca2+-activated K+ channel in planar lipid bilayers.
The Journal of membrane biology 1985;83(3):273-82.
1983: Ramon Latorre; Cecilia Vergara; Edward Moczydlowski
Properties of a Ca2+-activated K+ channel in a reconstituted system.
Cell calcium 1983;4(5-6):343-57.