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Jaime Modiano

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Daniel A Feeney; Michael S Henson; Brian D Husbands; Daisuke Ito; Carl R Jessen; Katherine L Bahr; Antonella Borgatti; Timothy D O'Brien; Leslie C Sharkey; Susan M Steward; Jaime F Modiano
Parenchymal signal intensity in 3-T body MRI of dogs with hematopoietic neoplasia.
Aaron L Sarver; Milcah C Scott; Anne-Marie Cleton-Jansen; Pancras Cw Hogendoorn; Jaime F Modiano; Venugopal Thayanithy; Subbaya Subramanian
MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.
Jaime F Modiano; Sibyl Munson; John Pozniak; Jerome Schaack; Milcah C Scott; Vicki L Wilke; Donald Bellgrau; Cathy S Carlson; J Brad Charles; Gary R Cutter; Ej Ehrhart; Nicole P Ehrhart; Susan E Lana; Richard C Duke
Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer.

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2013: Daniel A Feeney; Michael S Henson; Brian D Husbands; Daisuke Ito; Carl R Jessen; Katherine L Bahr; Antonella Borgatti; Timothy D O'Brien; Leslie C Sharkey; Susan M Steward; Jaime F Modiano
Parenchymal signal intensity in 3-T body MRI of dogs with hematopoietic neoplasia.
Comparative medicine 2013;63(2):174-82.
2013: Aaron L Sarver; Milcah C Scott; Anne-Marie Cleton-Jansen; Pancras Cw Hogendoorn; Jaime F Modiano; Venugopal Thayanithy; Subbaya Subramanian
MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.
Orphanet journal of rare diseases 2013;8():7.
2012: Jaime F Modiano; Sibyl Munson; John Pozniak; Jerome Schaack; Milcah C Scott; Vicki L Wilke; Donald Bellgrau; Cathy S Carlson; J Brad Charles; Gary R Cutter; Ej Ehrhart; Nicole P Ehrhart; Susan E Lana; Richard C Duke
Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(12):2234-43.
2012: Andrea Y Angstadt; Jaime F Modiano; Subbaya Subramanian; Venugopal Thayanithy; Matthew Breen
A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations.
Cancer genetics 2012;205(11):572-87.
2012: Daisuke Ito; Nicola J Mason; Timothy D O'Brien; Rachael Thomas; Christina Williams; Anne C Avery; Matthew Breen; Robert C Burnett; Aric M Frantz; Jaime F Modiano
CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies.
Leukemia & lymphoma 2012;53(7):1390-8.
2012: Greger Larson; Peter A Leegwater; Alexander I Agoulnik; Leif Andersson; Kenine E Comstock; Keith Dobney; Merete Fredholm; Simon Y W Ho; Elinor K. Karlsson; Frode Lingaas; Jaime F Modiano; Angela Perri; Joris Peters; Philip J Piper; Claude Schelling; Peter W Stahl; Jean-Denis Vigne; Carles Vilà; Matthew T Webster; Kerstin Lindblad-Toh
Rethinking dog domestication by integrating genetics, archeology, and biogeography.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):8878-83.
2012: Venugopal Thayanithy; Ashley J Graef; Reena V Kartha; Derek M Korpela; Jaime F Modiano; ChangWon Park; Aaron L Sarver; Clifford J Steer; Subbaya Subramanian
Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines.
PloS one 2012;7(9):e43720.
2011: Andrea Y Angstadt; Dawn L Duval; C Guillermo Couto; William C Kisseberth; Jaime F Modiano; Alison Motsinger-Reif; Dahlia M Nielsen; Rachael Thomas; Matthew Breen
Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart.
Genes, chromosomes & cancer 2011;50(11):859-74.
2011: Milcah C Scott; Subbaya Subramanian; Venugopal Thayanithy; Robert A Newman; Aaron L Sarver; Matthew Breen; Gary R Cutter; Katherine J Gavin; David M Getzy; Lawrence E Hunter; William C Kisseberth; Kerstin Lindblad-Toh; Jaime F Modiano
Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach.
Bone 2011;49(3):356-67.
2011: D Ito; Cristan M Jubala; William C Kisseberth; T D O'Brien; V E Valli; Anne C Avery; J S Bell; A Borgatti; K E Burgess; Robert C Burnett; Gary R Cutter; M M Endicott; K A Hahn; K M Helm; M S Henson; B D Husbands; Jaime F Modiano
A tumor-related lymphoid progenitor population supports hierarchical tumor organization in canine B-cell lymphoma.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2011;25(4):890-6.
2011: Rachael Thomas; Victor E Valli; David Argyle; Jerold Bell; Luke Borst; Kristine Burgess; Kathryn Kelley; Kerstin Lindblad-Toh; Jaime F Modiano; Alison Motsinger-Reif; Eric L Seiser; Steven E Suter; Matthew Breen
Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas.
Leukemia & lymphoma 2011;52(7):1321-35.
2010: Tatsuto Ishimaru; Jasmine Lau; Amy L Jackson; Jaime F Modiano; Robert H Weiss
Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma.
The Journal of urology 2010;184(5):2143-9.
2010: Silvia C S Oloris; Ashley A Frazer-Abel; Cristan M Jubala; Susan P Fosmire; Karen M Helm; Sally R Robinson; Derek M Korpela; Megan M Duckett; Shairaz Baksh; Jaime F Modiano
Nicotine-mediated signals modulate cell death and survival of T lymphocytes.
Toxicology and applied pharmacology 2010;242(3):299-309.
2010: Beth A Tamburini; Tzu L Phang; Susan P Fosmire; Milcah C Scott; Susan C Trapp; Megan M Duckett; Sally R Robinson; Jill E Slansky; Leslie C Sharkey; Gary R Cutter; John Wojcieszyn; Donald Bellgrau; Robert M Gemmill; Lawrence E Hunter; Jaime F Modiano
Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma.
BMC cancer 2010;10():619.
2009: Cristan M Jubala; Angela R Lamerato-Kozicki; Michelle Borakove; Julie Lang; Lori A Gardner; David Coffey; Karen M Helm; Jerome Schaack; Monika Baier; Gary R Cutter; Donald Bellgrau; Jaime F Modiano
MHC-dependent desensitization of intrinsic anti-self reactivity.
Cancer immunology, immunotherapy : CII 2009;58(2):171-85.
2009: Jamin A Willoughby; Shyam N Sundar; Mark Cheung; Antony S Tin; Jaime F Modiano; Gary L Firestone
Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.
The Journal of biological chemistry 2009;284(4):2203-13.
2009: Beth Tamburini; Susan Trapp; Tzu Lip Phang; Jill T Schappa; Lawrence Hunter; Jaime F Modiano
Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed.
PloS one 2009;4(5):e5549.
2009: Rachael Thomas; Huixia J Wang; Pei-Chien Tsai; Cordelia F Langford; Susan P Fosmire; Cristan M Jubala; Dave Getzy; Gary R Cutter; Jaime F Modiano; Matthew Breen
Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2009;17(3):365-77.
2008: Jaime F Modiano; Lisa D S Johnson; Donald Bellgrau
Negative regulators in homeostasis of naïve peripheral T cells.
Immunologic research 2008;41(2):137-53.
2008: Matthew Breen; Jaime F Modiano
Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionship.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2008;16(1):145-54.
2007: Susan P Fosmire; R Thomas; Cristan M Jubala; John Wojcieszyn; V E O Valli; Dave Getzy; T L Smith; L A Gardner; Michelle G Ritt; J S Bell; K P Freeman; B E Greenfield; Susan E Lana; William C Kisseberth; Stuart C Helfand; Gary R Cutter; Matthew Breen; Jaime F Modiano
Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma.
Veterinary pathology 2007;44(4):467-78.
2007: Pei-Yin Lin; Susan P Fosmire; See-Hyoung Park; Jin-Young Park; Shairaz Baksh; Jaime F Modiano; Robert H Weiss
Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.
Molecular cancer 2007;6():16.
2007: Jaime F Modiano; M Breen; V E O Valli; John Wojcieszyn; Gary R Cutter
Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma.
Leukemia 2007;21(1):184-7.
2006: Chand Khanna; Kerstin Lindblad-Toh; David M Vail; Cheryl London; Philip Bergman; Lisa Barber; Matthew Breen; Barbara E Kitchell; Elizabeth McNeil; Jaime F Modiano; Steven Niemi; Kenine Comstock; Elaine A Ostrander; Susan Westmoreland; Stephen Withrow
The dog as a cancer model.
Nature biotechnology 2006;24(9):1065-6.
2006: Angela R Lamerato-Kozicki; Karen M Helm; Cristan M Jubala; Gary R Cutter; Jaime F Modiano
Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation.
Experimental hematology 2006;34(7):870-8.
2005: Rachael Thomas; Allyson Scott; Cordelia F Langford; Susan P Fosmire; Cristan M Jubala; Travis D Lorentzen; Christophe Hitte; Elinor K. Karlsson; Ewen F Kirkness; Elaine A Ostrander; Francis Galibert; Kerstin Lindblad-Toh; Jaime F Modiano; Matthew Breen
Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors.
Genome research 2005;15(12):1831-7.
2005: Erin B Dickerson; R Thomas; Susan P Fosmire; A R Lamerato-Kozicki; Stacie R Bianco; John Wojcieszyn; Matthew Breen; Stuart C Helfand; Jaime F Modiano
Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
Veterinary pathology 2005;42(5):618-32.
2005: Cristan M Jubala; John Wojcieszyn; V E O Valli; Dave Getzy; Susan P Fosmire; D Coffey; Donald Bellgrau; Jaime F Modiano
CD20 expression in normal canine B cells and in canine non-Hodgkin lymphoma.
Veterinary pathology 2005;42(4):468-76.
2005: Jaime F Modiano; Matthew Breen; Robert C Burnett; Heidi G Parker; Seidu Inusah; Rachael Thomas; Paul R Avery; Kerstin Lindblad-Toh; Elaine A Ostrander; Gary R Cutter; Anne C Avery
Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk.
Cancer research 2005;65(13):5654-61.
2004: Ashley A Frazer-Abel; Shairaz Baksh; Susan P Fosmire; Derall Willis; Angela M Pierce; Heather Meylemans; Darwin S Linthicum; Steven J Burakoff; Teresa Coons; Donald Bellgrau; Jaime F Modiano
Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.
The Journal of pharmacology and experimental therapeutics 2004;311(2):758-69.
2004: Jaime F Modiano; Juan Sun; Julie Lang; Guido Vacano; David Patterson; Daniel Chan; Alex Franzusoff; Roberto Gianani; Sandra J Meech; Richard C Duke; Donald Bellgrau
Fas ligand-dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cells.
Clinical immunology (Orlando, Fla.) 2004;112(1):54-65.
2004: Susan P Fosmire; Erin B Dickerson; Allyson M Scott; Stacie R Bianco; Marilyn J Pettengill; Heather Meylemans; Marcia L Padilla; Ashley A Frazer-Abel; Nasim Akhtar; Dave Getzy; John Wojcieszyn; Matthew Breen; Stuart C Helfand; Jaime F Modiano
Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium.
Laboratory investigation; a journal of technical methods and pathology 2004;84(5):562-72.
2003: Stacie R Bianco; Juan Sun; Susan P Fosmire; Kenneth Hance; Marcia L Padilla; Michelle G Ritt; Dave Getzy; Richard C Duke; Stephen J Withrow; Susan E Lana; David T Matthiesen; Steven W Dow; Donald Bellgrau; Gary R Cutter; Stuart C Helfand; Jaime F Modiano
Enhancing antimelanoma immune responses through apoptosis.
Cancer gene therapy 2003;10(9):726-36.
2003: Jesica M McCue; Sabine Lazis; J John Cohen; Jaime F Modiano; Brian M Freed
Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phase.
Molecular immunology 2003;39(16):995-1001.
2003: Sangeeta Khare; Yona Banai; Kuppan Gokulan; Roger Smith; Darwin S Linthicum; Jaime F Modiano
Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs.
European journal of pharmacology 2003;465(1-2):23-30.
2003: Robert C Burnett; William Vernau; Jaime F Modiano; Christine S Olver; Peter F Moore; Anne C Avery
Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes.
Veterinary pathology 2003;40(1):32-41.
2002: Shairaz Baksh; Hans R Widlund; Ashley A Frazer-Abel; Jinyan Du; Susan P Fosmire; David E Fisher; James A DeCaprio; Jaime F Modiano; Steven J Burakoff
NFATc2-mediated repression of cyclin-dependent kinase 4 expression.
Molecular cell 2002;10(5):1071-81.
2002: A Koenig; Stacie R Bianco; Susan P Fosmire; John Wojcieszyn; Jaime F Modiano
Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma.
Veterinary pathology 2002;39(4):458-72.
2002: Peter J Fernandes; Jaime F Modiano; John Wojcieszyn; Jennifer S Thomas; Patricia A Benson; Roger Smith; Anne C Avery; Robert C Burnett; Laura I Boone; Mark C Johnson; Kenneth R Pierce
Use of the Cell-Dyn 3500 to predict leukemic cell lineage in peripheral blood of dogs and cats.
Veterinary clinical pathology / American Society for Veterinary Clinical Pathology 2002;31(4):167-82.
2002: Erin B Dickerson; Susan P Fosmire; Marcia L Padilla; Jaime F Modiano; Stuart C Helfand
Potential to target dysregulated interleukin-2 receptor expression in canine lymphoid and hematopoietic malignancies as a model for human cancer.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25(1):36-45.
2001: A Koenig; John Wojcieszyn; B R Weeks; Jaime F Modiano
Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma.
Veterinary pathology 2001;38(4):427-35.
2000: Jaime F Modiano; J Mayor; C Ball; M K Fuentes; Darwin S Linthicum
CDK4 expression and activity are required for cytokine responsiveness in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6693-702.
2000: Michelle G Ritt; J Mayor; John Wojcieszyn; Roger Smith; C L Barton; Jaime F Modiano
Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition.
Cancer letters 2000;158(1):73-84.
1999: Jaime F Modiano; J Mayor; C Ball; Carol Chitko-McKown; N Sakata; J Domenico-Hahn; J J Lucas; E W Gelfand
Quantitative and qualitative signals determine T-cell cycle entry and progression.
Cellular immunology 1999;197(1):19-29.
1999: Jaime F Modiano; Michelle G Ritt; John Wojcieszyn; Roger Smith
Growth arrest of melanoma cells is differentially regulated by contact inhibition and serum deprivation.
DNA and cell biology 1999;18(5):357-67.
1999: Jaime F Modiano; Michelle G Ritt; John Wojcieszyn
The molecular basis of canine melanoma: pathogenesis and trends in diagnosis and therapy.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1999;13(3):163-74.
1998: L I Boone; K W Knauer; S W Rapp; J F Stewart; Jaime F Modiano
Use of human recombinant erythropoietin and prednisone for treatment of myelodysplastic syndrome with erythroid predominance in a dog.
Journal of the American Veterinary Medical Association 1998;213(7):999-1001.
1998: Michelle G Ritt; John Wojcieszyn; Jaime F Modiano
Functional loss of p21/Waf-1 in a case of benign canine multicentric melanoma.
Veterinary pathology 1998;35(2):94-101.
1997: Carol Chitko-McKown; Jaime F Modiano
Clues to immune function and oncogenesis provided by events that activate the cell cycle machinery in normal human T cells.
Journal of leukocyte biology 1997;62(4):430-7.
1997: Jaime F Modiano; D Amran; G Lack; K Bradley; C Ball; J Domenico; Erwin W Gelfand
Posttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin.
Clinical immunology and immunopathology 1997;83(1):77-85.
1996: R M Walton; Jaime F Modiano; Mary Anna Thrall; S L Wheeler
Bone marrow cytological findings in 4 dogs and a cat with hemophagocytic syndrome.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 1996;10(1):7-14.
1995: Jaime F Modiano; J Domenico; A Szepesi; N Terada; J J Lucas; Erwin W Gelfand
Symmetry of the activation of cyclin-dependent kinases in mitogen and growth factor-stimulated T lymphocytes.
Annals of the New York Academy of Sciences 1995;766():134-48.
1995: Stuart C Helfand; Jaime F Modiano; Peter F Moore; S A Soergel; PS MacWilliams; R D Dubielzig; Jacquelyn A Hank; E W Gelfand; Paul M Sondel
Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma.
Blood 1995;86(2):636-45.
1995: J J Lucas; A Szepesi; Jaime F Modiano; J Domenico; Erwin W Gelfand
Regulation of synthesis and activity of the PLSTIRE protein (cyclin-dependent kinase 6 (cdk6)), a major cyclin D-associated cdk4 homologue in normal human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6275-84.
1995: Jaime F Modiano; Dave Getzy; K G Akol; T J Van Winkle; G L Cockerell
Retrovirus-like activity in an immunosuppressed dog: pathological and immunological findings.
Journal of comparative pathology 1995;112(2):165-83.
1994: Jaime F Modiano; J Domenico; A Szepesi; J J Lucas; Erwin W Gelfand
Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases Cdk4 and Cdk2 in human T cells.
The Journal of biological chemistry 1994;269(52):32972-8.
1994: Stuart C Helfand; S A Soergel; Jaime F Modiano; Jacquelyn A Hank; Paul M Sondel
Induction of lymphokine-activated killer (LAK) activity in canine lymphocytes with low dose human recombinant interleukin-2 in vitro.
Cancer biotherapy 1994;9(3):237-44.
1992: Stuart C Helfand; Jaime F Modiano; P C Nowell
Immunophysiological studies of interleukin-2 and canine lymphocytes.
Veterinary immunology and immunopathology 1992;33(1-2):1-16.
1991: Jaime F Modiano; R Kolp; R J Lamb; Peter C Nowell
Protein kinase C regulates both production and secretion of interleukin 2.
The Journal of biological chemistry 1991;266(16):10552-61.
1991: Jaime F Modiano; Y Kokai; David B Weiner; M J Pykett; Peter C Nowell; C R Lyttle
Progesterone augments proliferation induced by epidermal growth factor in a feline mammary adenocarcinoma cell line.
Journal of cellular biochemistry 1991;45(2):196-206.
1988: Jaime F Modiano; E Kelepouris; J A Kern; Peter C Nowell
Requirement for extracellular calcium or magnesium in mitogen-induced activation of human peripheral blood lymphocytes.
Journal of cellular physiology 1988;135(3):451-8.