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Robert Modlin

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Adam J Friedman; Karin Blecher-Paz; Jackson Champer; Phil T Liu; Robert L Modlin; Ami Oren; Jenny Phan; Aslan Pirouz; Min Qin; David O Schairer; Jenny Kim
Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens.
Rosane M B Teles; Dennis Montoya; Stephen J Popper; Thomas H Rea; David A Relman; Euzenir N Sarno; Mirjam Schenk; Steffen Stenger; John S Adams; Barry R Bloom; Genhong Cheng; Rene Chun; Thomas G Graeber; Martin Hewison; Shankar S Iyer; Kindra Kelly-Scumpia; Evangelia Komisopoulou; Stephan R Krutzik; Delphine J Lee; Robert L Modlin
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.
Deborah Jacobs-Sera; Laura J Marinelli; Robert L Modlin; Zaritza O Petrova; Welkin H Pope; Charles Bowman; Michelle M Boyle; Gregory W Broussard; Rebekah M Dedrick; Carlos Guerrero Bustamante; Roger W Hendrix; Graham F Hatfull
On the nature of mycobacteriophage diversity and host preference.

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2013: Adam J Friedman; Karin Blecher-Paz; Jackson Champer; Phil T Liu; Robert L Modlin; Ami Oren; Jenny Phan; Aslan Pirouz; Min Qin; David O Schairer; Jenny Kim
Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens.
The Journal of investigative dermatology 2013;133(5):1231-9.
2013: Rosane M B Teles; Dennis Montoya; Stephen J Popper; Thomas H Rea; David A Relman; Euzenir N Sarno; Mirjam Schenk; Steffen Stenger; John S Adams; Barry R Bloom; Genhong Cheng; Rene Chun; Thomas G Graeber; Martin Hewison; Shankar S Iyer; Kindra Kelly-Scumpia; Evangelia Komisopoulou; Stephan R Krutzik; Delphine J Lee; Robert L Modlin
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.
Science (New York, N.Y.) 2013;339(6126):1448-53.
2012: Deborah Jacobs-Sera; Laura J Marinelli; Robert L Modlin; Zaritza O Petrova; Welkin H Pope; Charles Bowman; Michelle M Boyle; Gregory W Broussard; Rebekah M Dedrick; Carlos Guerrero Bustamante; Roger W Hendrix; Graham F Hatfull
On the nature of mycobacteriophage diversity and host preference.
Virology 2012;434(2):187-201.
2012: Kislay Parvatiyar; Mirjam Schenk; Rosane M B Teles; Shivam A Zaver; Shang Zeng; Zhiqiang Zhang; Wenwan Zhong; Shankar S Iyer; Yan Jiang; Yong-jun Liu; Zhi-Jie Liu; Robert L Modlin; Songying Ouyang; Genhong Cheng
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.
Nature immunology 2012;13(12):1155-61.
2012: Jordi B Torrelles; Nannan Zhang; John T Belisle; Patrick J Brennan; Mark A Keen; Michael R McNeil; Robert L Modlin; Peter Allan Sieling; Delphi Chatterjee
Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells.
Glycobiology 2012;22(8):1118-27.
2012: Mirjam Schenk; Peter Allan Sieling; Rosane M B Teles; Maria Teresa Ochoa; Thomas H Rea; Euzenir N Sarno; Genhong Cheng; Thomas G Graeber; Soohyun Kim; Evangelia Komisopoulou; Stephan R Krutzik; Delphine J Lee; Robert L Modlin
NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.
Nature medicine 2012;18(4):555-63.
2012: Robert L Modlin
Innate immunity: ignored for decades, but not forgotten.
The Journal of investigative dermatology 2012;132(3 Pt 2):882-6.
2012: Philip T Liu; Manali D Mehta; Kristina Edfeldt; Benjamin Ferguson; Thomas G Graeber; Evangelia Komisopoulou; Thomas H Rea; Euzenir N Sarno; Rosane M B Teles; Aria Vazirnia; Matthew Wheelwright; Robert L Modlin
MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy.
Nature medicine 2012;18(2):267-73.
2012: Laura J Marinelli; Jeff F Miller; Matteo Pellegrini; Daniel A Russell; Charles Bowman; Shawn Cokus; Sorel Fitz-Gibbon; Graham F Hatfull; Clarmyra Hayes; Megan Inkeles; Deborah Jacobs-Sera; Jenny Kim; Anya Loncaric; Robert L Modlin
Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates.
mBio 2012;3(5):.
2011: Susan Realegeno; Robert L Modlin
Shedding light on the vitamin D-tuberculosis-HIV connection.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):18861-2.
2011: Mario Fabri; Martin Hewison; Bruce W Hollis; Shankar S Iyer; Eun-Kyeong Jo; Stephan R Krutzik; Hye-Mi Lee; David M Lewinsohn; Philip T Liu; Dennis Montoya; Susan Realegeno; Mirjam Schenk; Dong-Min Shin; Peter Allan Sieling; Andreas Steinmeyer; Steffen Stenger; Rosane M B Teles; Jae-Min Yuk; Ulrich Zügel; John S Adams; Barry R Bloom; Heiko Bruns; Genhong Cheng; Robert L Modlin
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.
Science translational medicine 2011;3(104):104ra102.
2011: John S Cho; Jamie Zussman; Niles P Donegan; Romela Irene Ramos; Nairy C Garcia; Daniel Z Uslan; Yoichiro Iwakura; Scott I Simon; Ambrose L Cheung; Robert L Modlin; Jenny Kim; Lloyd S Miller
Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections.
The Journal of investigative dermatology 2011;131(4):907-15.
2011: Mario Fabri; Susan E Realegeno; Eun-Kyeong Jo; Robert L Modlin
Role of autophagy in the host response to microbial infection and potential for therapy.
Current opinion in immunology 2011;23(1):65-70.
2010: Kristina Edfeldt; Philip T Liu; Rene Chun; Mario Fabri; Mirjam Schenk; Matthew Wheelwright; Caroline Keegan; Stephan R Krutzik; John S Adams; Martin Hewison; Robert L Modlin
T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22593-8.
2010: Rosane M B Teles; Stephan R Krutzik; Maria Teresa Ochoa; Rosane Barbosa de Oliveira; Euzenir N Sarno; Robert L Modlin
Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy.
Infection and immunity 2010;78(11):4634-43.
2010: Maria T Ochoa; Rosane M B Teles; Blake E Haas; Danny Zaghi; Huiying Li; Euzenir N Sarno; Thomas H Rea; Robert L Modlin; Delphine J Lee
A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy.
Immunology 2010;131(3):405-14.
2010: Rene F Chun; Anna L Lauridsen; Lizabeth Suon; Lee A Zella; J Wesley Pike; Robert L Modlin; Adrian R Martineau; Robert J Wilkinson; John Adams; Martin Hewison
Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D.
The Journal of clinical endocrinology and metabolism 2010;95(7):3368-76.
2010: John S Cho; Eric M Pietras; Nairy C Garcia; Romela Irene Ramos; David M Farzam; Holly R Monroe; Julie E Magorien; Andrew Blauvelt; Jay K Kolls; Ambrose L Cheung; Genhong Cheng; Robert L Modlin; Lloyd S Miller
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
The Journal of clinical investigation 2010;120(5):1762-73.
2010: Delphine J Lee; Huiying Li; Maria T Ochoa; Motoyuki Tanaka; Ryan J Carbone; Robert Damoiseaux; Anne E Burdick; Euzenir N Sarno; Thomas H Rea; Robert L Modlin
Integrated pathways for neutrophil recruitment and inflammation in leprosy.
The Journal of infectious diseases 2010;201(4):558-69.
2010: Robert L Modlin
The innate immune response in leprosy.
Current opinion in immunology 2010;22(1):48-54.
2010: Dennis Montoya; Robert L Modlin
Learning from leprosy: insight into the human innate immune response.
Advances in immunology 2010;105():1-24.
2009: Mirjam Schenk; John T Belisle; Robert L Modlin
TLR2 looks at lipoproteins.
Immunity 2009;31(6):847-9.
2009: Dennis Montoya; Daniel Cruz; Rosane M B Teles; Delphine J Lee; Maria Teresa Ochoa; Stephan R Krutzik; Rene Chun; Mirjam Schenk; Xiaoran Zhang; Benjamin G Ferguson; Anne E Burdick; Euzenir N Sarno; Thomas H Rea; Martin Hewison; John S Adams; Genhong Cheng; Robert L Modlin
Divergence of macrophage phagocytic and antimicrobial programs in leprosy.
Cell host & microbe 2009;6(4):343-53.
2009: Mario Fabri; Robert L Modlin
A vitamin for autophagy.
Cell host & microbe 2009;6(3):201-3.
2009: Motoyuki Tanaka; Stephan R Krutzik; Peter Allan Sieling; Delphine J Lee; Thomas H Rea; Robert L Modlin
Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2349-55.
2009: Robert L Modlin; Michael B Brenner
T cell responses in microbial infection.
Current opinion in immunology 2009;21(4):365-6.
2009: Valencia P Walker; Robert L Modlin
The vitamin D connection to pediatric infections and immune function.
Pediatric research 2009;65(5 Pt 2):106R-113R.
2009: John S Adams; Songyang Ren; Philip T Liu; Rene Chun; Venu Lagishetty; Adrian F Gombart; Niels Borregaard; Robert L Modlin; Martin Hewison
Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4289-95.
2009: Philip T Liu; Mirjam Schenk; Valencia P Walker; Paul W Dempsey; Melissa Kanchanapoomi; Matthew Wheelwright; Aria Vazirnia; Xiaoran Zhang; Andreas Steinmeyer; Ulrich Zügel; Bruce W Hollis; Genhong Cheng; Robert L Modlin
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.
PloS one 2009;4(6):e5810.
2008: Delphine J Lee; Robert L Modlin
DNA transportation authority.
Nature medicine 2008;14(12):1319-20.
2008: Stephan R Krutzik; Martin Hewison; Philip T Liu; Juan Antonio Robles; Steffen Stenger; John S Adams; Robert L Modlin
IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7115-20.
2008: Maria Teresa Ochoa; Anya Loncaric; Stephan R Krutzik; Todd C Becker; Robert L Modlin
"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages.
The Journal of investigative dermatology 2008;128(9):2225-31.
2008: Daniel Cruz; Andrew D Watson; Christopher S Miller; Dennis Montoya; Maria Teresa Ochoa; Peter Allan Sieling; Miguel A Gutierrez; Mohamad Navab; Srinivasa T Reddy; Joseph L Witztum; Alan M Fogelman; Thomas H Rea; David Eisenberg; Judith A Berliner; Robert L Modlin
Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.
The Journal of clinical investigation 2008;118(8):2917-28.
2008: Philip T Liu; Robert L Modlin
Human macrophage host defense against Mycobacterium tuberculosis.
Current opinion in immunology 2008;20(4):371-6.
2008: Peter Allan Sieling; Preston J Hill; Karen M Dobos; Kerry Brookman; Andrew M Kuhlman; Mario Fabri; Stephan R Krutzik; Thomas H Rea; Darragh G Heaslip; John Belisle; Robert L Modlin
Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5833-42.
2007: Delphine J Lee; Peter Allan Sieling; Maria Teresa Ochoa; Stephan R Krutzik; Beichu Guo; Maristela Hernandez; Thomas H Rea; Genhong Cheng; Marco COLONna; Robert L Modlin
LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8128-36.
2007: Kayvan R Niazi; Maria Teresa Ochoa; Peter Allan Sieling; Nanette E Rooke; Anna K Peter; Pamela Mollahan; Micah Dickey; Shahrooz Rabizadeh; Thomas H Rea; Robert L Modlin
Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences.
Immunology 2007;122(4):522-31.
2007: Lloyd S Miller; Eric M Pietras; Lawrence H Uricchio; Kathleen Hirano; Shyam Rao; Heping Lin; Ryan M O'Connell; Yoichiro Iwakura; Ambrose L Cheung; Genhong Cheng; Robert L Modlin
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6933-42.
2007: John S Adams; Philip T Liu; Rene Chun; Robert L Modlin; Martin Hewison
Vitamin D in defense of the human immune response.
Annals of the New York Academy of Sciences 2007;1117():94-105.
2007: Philip T Liu; Steffen Stenger; Dominic H Tang; Robert L Modlin
Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2060-3.
2007: Lloyd S Miller; Robert L Modlin
Toll-like receptors in the skin.
Seminars in immunopathology 2007;29(1):15-26.
2007: Peter Allan Sieling; Annaliza J Legaspi; Maria Teresa Ochoa; Thomas H Rea; Robert L Modlin
Regulation of human T-cell homing receptor expression in cutaneous bacterial infection.
Immunology 2007;120(4):518-25.
2007: Jürgen Schauber; Robert A Dorschner; Alvin Coda; Amanda S Büchau; Philip T Liu; David Kiken; Yolanda Rosi Helfrich; Sewon Kang; Hashem Z Elalieh; Andreas Steinmeyer; Ulrich Zügel; Daniel David Bikle; Robert L Modlin; Richard L Gallo
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
The Journal of clinical investigation 2007;117(3):803-11.
2007: Philip T Liu; Stephan R Krutzik; Robert L Modlin
Therapeutic implications of the TLR and VDR partnership.
Trends in molecular medicine 2007;13(3):117-24.
2007: Shereen Sabet; Maria Teresa Ochoa; Peter Allan Sieling; Thomas H Rea; Robert L Modlin
Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion.
Immunology 2007;120(3):354-61.
2007: Anna Di Nardo; Marissa H Braff; Kristen R Taylor; Changrim Na; Richard D Granstein; Jamie E McInturff; Stephan R Krutzik; Robert L Modlin; Richard L Gallo
Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1829-34.
2007: Lloyd S Miller; Robert L Modlin
Human keratinocyte Toll-like receptors promote distinct immune responses.
The Journal of investigative dermatology 2007;127(2):262-3.
2006: Edward K. Chow; Antonio Castrillo; Arash Shahangian; Liming Pei; Ryan M O'Connell; Robert L Modlin; Peter Tontonoz; Genhong Cheng
A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections.
The Journal of experimental medicine 2006;203(12):2589-602.
2006: Jin S Im; Nikos Tapinos; Gue-Tae Chae; Petr A Illarionov; Gurdyal S Besra; George Henry De Vries; Robert L Modlin; Peter Allan Sieling; Anura Rambukkana; Steven A Porcelli
Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5226-35.
2006: Belinda H Tan; Christoph Meinken; Max Bastian; Heiko Bruns; Annaliza J Legaspi; Maria Teresa Ochoa; Stephan R Krutzik; Barry R Bloom; Tomas Ganz; Robert L Modlin; Steffen Stenger
Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1864-71.
2006: Claudia N Renn; David Jesse Sanchez; Maria Teresa Ochoa; Annaliza J Legaspi; Chang-Keun Oh; Philip T Liu; Stephan R Krutzik; Peter Allan Sieling; Genhong Cheng; Robert L Modlin
TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):298-305.
2006: Philip T Liu; Steffen Stenger; Huiying Li; Linda Wenzel; Belinda H Tan; Stephan R Krutzik; Maria Teresa Ochoa; Jürgen Schauber; Kent Wu; Christoph Meinken; Diane L Kamen; Manfred Wagner; Robert Bals; Andreas Steinmeyer; Ulrich Zügel; Richard L Gallo; David Eisenberg; Martin Hewison; Bruce W Hollis; John S Adams; Barry R Bloom; Robert L Modlin
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Science (New York, N.Y.) 2006;311(5768):1770-3.
2006: Lloyd S Miller; Ryan M O'Connell; Miguel A Gutierrez; Eric M Pietras; Arash Shahangian; Catherine E Gross; Ajaykumar Thirumala; Ambrose L Cheung; Genhong Cheng; Robert L Modlin
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus.
Immunity 2006;24(1):79-91.
2005: Frank Stegelmann; Max Bastian; Kay Swoboda; Rauf Bhat; Viviane Kiessler; Alan Krensky; Martin Roellinghoff; Robert L Modlin; Steffen Stenger
Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7474-83.
2005: Jamie E McInturff; Shyh-Jeun Wang; thomas machleidt; T Richard Lin; Ami Oren; Cheryl J Hertz; Stephan R Krutzik; Scott Hart; Karin Zeh; Daniel H Anderson; Richard L Gallo; Robert L Modlin; Jenny Kim
Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes.
The Journal of investigative dermatology 2005;125(2):256-63.
2005: Robert L Modlin; Peter Allan Sieling
Immunology. Now presenting: gammadelta T cells.
Science (New York, N.Y.) 2005;309(5732):252-3.
2005: Jamie E McInturff; Robert L Modlin; Jenny Kim
The role of toll-like receptors in the pathogenesis and treatment of dermatological disease.
The Journal of investigative dermatology 2005;125(1):1-8.
2005: Stephan R Krutzik; Belinda Tan; Huiying Li; Maria Teresa Ochoa; Philip T Liu; Sarah E Sharfstein; Thomas G Graeber; Peter Allan Sieling; Yong-Jun Liu; Thomas H Rea; Barry R Bloom; Robert L Modlin
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.
Nature medicine 2005;11(6):653-60.
2005: Lloyd S Miller; Ole E Sørensen; Philip T Liu; H Ray Jalian; Deborah Eshtiaghpour; Behnaz E Behmanesh; Woosin Chung; Timothy D Starner; Jenny Kim; Peter Allan Sieling; Tomas Ganz; Robert L Modlin
TGF-alpha regulates TLR expression and function on epidermal keratinocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6137-43.
2005: Peter Allan Sieling; Jordi B Torrelles; Steffen Stenger; Woosin Chung; Anne E Burdick; Thomas H Rea; Patrick J Brennan; John Belisle; Steven A Porcelli; Robert L Modlin
The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2637-44.
2005: Philip T Liu; Stephan R Krutzik; Jenny Kim; Robert L Modlin
Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2467-70.
2005: Delphine J Lee; Robert L Modlin
Breaking tolerance--another piece added to the vitiligo puzzle.
The Journal of investigative dermatology 2005;124(1):xiii-xv.
2004: Jordi B Torrelles; Kay-Hooi Khoo; Peter Allan Sieling; Robert L Modlin; Nannan Zhang; Angela M Marques; Achim Treumann; Christopher D Rithner; Patrick J Brennan; Delphi Chatterjee
Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis.
The Journal of biological chemistry 2004;279(39):41227-39.
2004: Robert E Hunger; Peter Allan Sieling; Maria Teresa Ochoa; Makoto Sugaya; Anne E Burdick; Thomas H Rea; Patrick J Brennan; John Belisle; Andrew Blauvelt; Steven A Porcelli; Robert L Modlin
Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
The Journal of clinical investigation 2004;113(5):701-8.
2004: Stephan R Krutzik; Robert L Modlin
The role of Toll-like receptors in combating mycobacteria.
Seminars in immunology 2004;16(1):35-41.
2004: Sean E Doyle; Ryan M O'Connell; Gustavo A Miranda; Sagar A Vaidya; Edward K. Chow; Philip T Liu; Shinobu Suzuki; Nobutaka Suzuki; Robert L Modlin; Wen-Chen Yeh; Timothy F Lane; Genhong Cheng
Toll-like receptors induce a phagocytic gene program through p38.
The Journal of experimental medicine 2004;199(1):81-90.
2003: Cheryl J Hertz; Qi Wu; Edith Martin Porter; Yan J Zhang; Karl-Heinz Weismüller; Paul J Godowski; Tomas Ganz; Scott H Randell; Robert L Modlin
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6820-6.
2003: Joshua R Bleharski; Huiying Li; Christoph Meinken; Thomas G Graeber; Maria Teresa Ochoa; Masahiro Yamamura; Anne E Burdick; Euzenir N Sarno; Manfred Wagner; Martin Röllinghoff; Thomas H Rea; Marco COLONna; Steffen Stenger; Barry R Bloom; David Eisenberg; Robert L Modlin
Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
Science (New York, N.Y.) 2003;301(5639):1527-30.
2003: Kimberly A Walton; Amy L Cole; Michael Yeh; Ganesamoorthy Subbanagounder; Stephan R Krutzik; Robert L Modlin; Robert M Lucas; Junko Nakai; Eric J Smart; Devendra K Vora; Judith A Berliner
Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(7):1197-203.
2003: Stephan R Krutzik; Maria Teresa Ochoa; Peter Allan Sieling; Satoshi Uematsu; Yolanda W Ng; Annaliza J Legaspi; Philip T Liu; Stewart T Cole; Paul J Godowski; Yumi Maeda; Euzenir N Sarno; Michael V Norgard; Patrick J Brennan; Shizuo Akira; Thomas H Rea; Robert L Modlin
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
Nature medicine 2003;9(5):525-32.
2003: Joshua R Bleharski; Viviane Kiessler; Cecilia Buonsanti; Peter Allan Sieling; Steffen Stenger; Marco COLONna; Robert L Modlin
A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3812-8.
2003: Jennifer L Gansert; Viviane Kiessler; Matthias Engele; Frederick Wittke; Martin Röllinghoff; Alan Krensky; Steven A Porcelli; Robert L Modlin; Steffen Stenger
Human NKT cells express granulysin and exhibit antimycobacterial activity.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3154-61.
2003: Cheryl J Hertz; Robert L Modlin
Role of toll-like receptors in response to bacterial infection.
Contributions to microbiology 2003;10():149-63.
2003: Maria Teresa Ochoa; Annaliza J Legaspi; Zena Hatziris; Paul J Godowski; Robert L Modlin; Peter Allan Sieling
Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue.
Immunology 2003;108(1):10-5.
2003: Peter Allan Sieling; Woosin Chung; Baochau T Duong; Paul J Godowski; Robert L Modlin
Toll-like receptor 2 ligands as adjuvants for human Th1 responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):194-200.
2002: Sean Doyle; Sagar Vaidya; Ryan M O'Connell; Hajir Dadgostar; Paul W Dempsey; Ting Wu; Govinda Rao; Ren Sun; Margaret Haberland; Robert L Modlin; Genhong Cheng
IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
Immunity 2002;17(3):251-63.
2002: Kayvan R Niazi; Steven A Porcelli; Robert L Modlin
The CD1b structure: antigen presentation adapts to a high-fat diet.
Nature immunology 2002;3(8):703-4.
2002: Jenny Kim; Maria Teresa Ochoa; Stephan R Krutzik; Osamu Takeuchi; Satoshi Uematsu; Annaliza J Legaspi; Hans D Brightbill; Diana Holland; William J Cunliffe; Shizuo Akira; Peter Allan Sieling; Paul J Godowski; Robert L Modlin
Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1535-41.
2002: Steffen Stenger; Robert L Modlin
Control of Mycobacterium tuberculosis through mammalian Toll-like receptors.
Current opinion in immunology 2002;14(4):452-7.
2002: Robert L Modlin
Mammalian toll-like receptors.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2002;88(6):543-7; quiz 548-50, 583.
2002: Peter Allan Sieling; Robert L Modlin
Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders.
Current opinion in microbiology 2002;5(1):70-5.
2002: Robert L Modlin
Learning from leprosy: insights into contemporary immunology from an ancient disease.
Skin pharmacology and applied skin physiology 2002;15(1):1-6.
2001: Robert L Modlin; Barry R Bloom
Immunology. Chip shots--will functional genomics get functional?
Science (New York, N.Y.) 2001;294(5543):799-801.
2001: Robert L Modlin
Activation of toll-like receptors by microbial lipoproteins: role in host defense.
The Journal of allergy and clinical immunology 2001;108(4 Suppl):S104-6.
2001: Joshua R Bleharski; Kayvan R Niazi; Peter Allan Sieling; G Cheng; Robert L Modlin
Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3174-81.
2001: Jenny Kim; K Uyemura; M K Van Dyke; Annaliza J Legaspi; Thomas H Rea; Ke Shuai; Robert L Modlin
A role for IL-12 receptor expression and signal transduction in host defense in leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):779-86.
2001: S Thoma-Uszynski; Steffen Stenger; O Takeuchi; Maria Teresa Ochoa; Matthias Engele; Peter Allan Sieling; PF Barnes; M Rollinghoff; P L Bolcskei; Manfred Wagner; Shizuo Akira; Michael V Norgard; John Belisle; Paul J Godowski; Barry R Bloom; Robert L Modlin
Induction of direct antimicrobial activity through mammalian toll-like receptors.
Science (New York, N.Y.) 2001;291(5508):1544-7.
2001: Kayvan R Niazi; M Chiu; R Mendoza; M Degano; S Khurana; D Moody; A Melián; I Wilson; Mitchell Kronenberg; Steven A Porcelli; Robert L Modlin
The A' and F' pockets of human CD1b are both required for optimal presentation of lipid antigens to T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2562-70.
2001: Cheryl J Hertz; Sylvia M Kiertscher; Paul J Godowski; DA Bouis; Michael V Norgard; Michael D Roth; Robert L Modlin
Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2444-50.
2001: Maria Teresa Ochoa; Steffen Stenger; Peter Allan Sieling; S Thoma-Uszynski; Shereen Sabet; S Cho; Alan Krensky; M Rollinghoff; E Nunes Sarno; Anne E Burdick; Thomas H Rea; Robert L Modlin
T-cell release of granulysin contributes to host defense in leprosy.
Nature medicine 2001;7(2):174-9.
2001: Stephan R Krutzik; Peter Allan Sieling; Robert L Modlin
The role of Toll-like receptors in host defense against microbial infection.
Current opinion in immunology 2001;13(1):104-8.
2000: W A Ernst; S Thoma-Uszynski; R Teitelbaum; C Ko; DA Hanson; Carol Clayberger; Alan Krensky; M Leippe; Barry R Bloom; Tomas Ganz; Robert L Modlin
Granulysin, a T cell product, kills bacteria by altering membrane permeability.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7102-8.
2000: Maria Teresa Ochoa; S Thoma-Uszynski; Peter Allan Sieling; Shereen Sabet; S Cho; Alan Krensky; Anne E Burdick; Thomas H Rea; Robert L Modlin
Role of granulysin in immunity to leprosy.
Leprosy review 2000;71 Suppl():S115; discussion S115-6.
2000: S Thoma-Uszynski; Steffen Stenger; Robert L Modlin
CTL-mediated killing of intracellular Mycobacterium tuberculosis is independent of target cell nuclear apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5773-9.
2000: S Cho; V Mehra; S Thoma-Uszynski; Steffen Stenger; NV Serbina; RJ Mazzaccaro; J L Flynn; P F Barnes; Scott Southwood; E Celis; Barry R Bloom; Robert L Modlin; A Sette
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12210-5.
2000: A Melián; G F Watts; Abdijapar Shamshiev; Gennaro De Libero; A Clatworthy; M Vincent; Michael B Brenner; Samuel M Behar; Kayvan R Niazi; Robert L Modlin; Steven C Almo; David A Ostrov; Stanley G Nathenson; Steven A Porcelli
Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4494-504.
2000: S Thoma-Uszynski; Sylvia M Kiertscher; Maria Teresa Ochoa; DA Bouis; Michael V Norgard; K Miyake; Paul J Godowski; Michael D Roth; Robert L Modlin
Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3804-10.
2000: Hans D Brightbill; Robert L Modlin
Toll-like receptors: molecular mechanisms of the mammalian immune response.
Immunology 2000;101(1):1-10.
2000: P S Yamauchi; Joshua R Bleharski; K Uyemura; Jenny Kim; Peter Allan Sieling; A Miller; Hans D Brightbill; K Schlienger; Thomas H Rea; Robert L Modlin
A role for CD40-CD40 ligand interactions in the generation of type 1 cytokine responses in human leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1506-12.
2000: Peter Allan Sieling; Maria Teresa Ochoa; D Jullien; David S Leslie; Shereen Sabet; Jean-Pierre Rosat; Anne E Burdick; Thomas H Rea; Michael B Brenner; Steven A Porcelli; Robert L Modlin
Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4790-6.
2000: Hans D Brightbill; Scott Plevy; Robert L Modlin; Stephen T Smale
A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1940-51.
1999: Steffen Stenger; Jean-Pierre Rosat; Barry R Bloom; Alan Krensky; Robert L Modlin
Granulysin: a lethal weapon of cytolytic T cells.
Immunology today 1999;20(9):390-4.
1999: Hans D Brightbill; D H Libraty; Stephan R Krutzik; RB Yang; John Belisle; Joshua R Bleharski; M Maitland; Michael V Norgard; Scott Plevy; S T Smale; Patrick J Brennan; Barry R Bloom; Paul J Godowski; Robert L Modlin
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Science (New York, N.Y.) 1999;285(5428):732-6.
1999: Robert L Modlin; Hans D Brightbill; Paul J Godowski
The toll of innate immunity on microbial pathogens.
The New England journal of medicine 1999;340(23):1834-5.
1999: VE García; K Uyemura; Peter Allan Sieling; Maria Teresa Ochoa; Craig Morita; H Okamura; M Kurimoto; Thomas H Rea; Robert L Modlin
IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6114-21.
1999: Peter Allan Sieling; D Jullien; M Dahlem; T F Tedder; Thomas H Rea; Robert L Modlin; Steven A Porcelli
CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1851-8.
1999: Ethan P Grant; M Degano; Jean-Pierre Rosat; Steffen Stenger; Robert L Modlin; Ian A Wilson; Steven A Porcelli; Michael B Brenner
Molecular recognition of lipid antigens by T cell receptors.
The Journal of experimental medicine 1999;189(1):195-205.
1999: Steven A Porcelli; Robert L Modlin
The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids.
Annual review of immunology 1999;17():297-329.
1999: Jean-Pierre Rosat; Ethan P Grant; Evan M Beckman; Christopher Dascher; Peter Allan Sieling; Daphney Frederique; Robert L Modlin; Steven A Porcelli; Stephen T Furlong; Michael B Brenner
CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):366-71.
1998: Steffen Stenger; DA Hanson; R Teitelbaum; P Dewan; Kayvan R Niazi; C J Froelich; Tomas Ganz; S Thoma-Uszynski; A Melián; C Bogdan; Steven A Porcelli; Barry R Bloom; Alan Krensky; Robert L Modlin
An antimicrobial activity of cytolytic T cells mediated by granulysin.
Science (New York, N.Y.) 1998;282(5386):121-5.
1998: Steffen Stenger; Kayvan R Niazi; Robert L Modlin
Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3582-8.
1998: K Schlienger; K Uyemura; D Jullien; Peter Allan Sieling; Thomas H Rea; Peter Linsley; Robert L Modlin
B7-1, but not CD28, is crucial for the maintenance of the CD4+ T cell responses in human leprosy.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2407-13.
1998: Steffen Stenger; Robert L Modlin
Cytotoxic T cell responses to intracellular pathogens.
Current opinion in immunology 1998;10(4):471-7.
1998: Rick M Fairhurst; C X Wang; Peter Allan Sieling; Robert L Modlin; Jonathan Braun
CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B.
Infection and immunity 1998;66(8):3523-6.
1998: Rick M Fairhurst; C X Wang; Peter Allan Sieling; Robert L Modlin; Jonathan Braun
CD1-restricted T cells and resistance to polysaccharide-encapsulated bacteria.
Immunology today 1998;19(6):257-9.
1998: VE García; D Jullien; M Song; K Uyemura; Ke Shuai; Craig Morita; Robert L Modlin
IL-15 enhances the response of human gamma delta T cells to nonpeptide [correction of nonpetide] microbial antigens.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4322-9.
1998: S Fujieda; Peter Allan Sieling; Robert L Modlin; Andrew Saxon
CD1-restricted T-cells influence IgG subclass and IgE production.
The Journal of allergy and clinical immunology 1998;101(4 Pt 1):545-51.
1998: RM Jackman; Steffen Stenger; A Lee; D Branch Moody; Rick A Rogers; Kayvan R Niazi; Masahiko Sugita; Robert L Modlin; Peter J Peters; Steven A Porcelli
The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens.
Immunity 1998;8(3):341-51.
1998: W A Ernst; J Maher; S Cho; Kayvan R Niazi; D Chatterjee; D Branch Moody; G S Besra; Y Watanabe; P E Jensen; Steven A Porcelli; Mitchell Kronenberg; Robert L Modlin
Molecular interaction of CD1b with lipoglycan antigens.
Immunity 1998;8(3):331-40.
1998: J Gong; Steffen Stenger; J A Zack; B E Jones; Gregory Bristol; Robert L Modlin; P J Morrissey; PF Barnes
Isolation of mycobacterium-reactive CD1-restricted T cells from patients with human immunodeficiency virus infection.
The Journal of clinical investigation 1998;101(2):383-9.
1998: RJ Mazzaccaro; Steffen Stenger; K L Rock; Steven A Porcelli; Michael B Brenner; Robert L Modlin; Barry R Bloom
Cytotoxic T lymphocytes in resistance to tuberculosis.
Advances in experimental medicine and biology 1998;452():85-101.
1997: D Branch Moody; BB Reinhold; Mark R Guy; Evan M Beckman; Daphney Frederique; Stephen T Furlong; S Ye; Vernon N Reinhold; Peter Allan Sieling; Robert L Modlin; Gurdyal S Besra; Steven A Porcelli
Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells.
Science (New York, N.Y.) 1997;278(5336):283-6.
1997: VE García; Peter Allan Sieling; J Gong; P F Barnes; K Uyemura; Y Tanaka; Barry R Bloom; Craig Morita; Robert L Modlin
Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1328-35.
1997: Laurent Brossay; D Jullien; S Cardell; Beate C Sydora; N Burdin; Robert L Modlin; Mitchell Kronenberg
Mouse CD1 is mainly expressed on hemopoietic-derived cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1216-24.
1997: J Kim; Alessandro Sette; S Rodda; Scott Southwood; Peter Allan Sieling; V Mehra; J D Ohmen; J Oliveros; Ettore Appella; Y Higashimoto; Thomas H Rea; Barry R Bloom; Robert L Modlin
Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):335-43.
1997: Steffen Stenger; RJ Mazzaccaro; K Uyemura; S Cho; PF Barnes; Jean-Pierre Rosat; A Sette; Michael B Brenner; Steven A Porcelli; Barry R Bloom; Robert L Modlin
Differential effects of cytolytic T cell subsets on intracellular infection.
Science (New York, N.Y.) 1997;276(5319):1684-7.
1997: D Jullien; Steffen Stenger; W A Ernst; Robert L Modlin
CD1 presentation of microbial nonpeptide antigens to T cells.
The Journal of clinical investigation 1997;99(9):2071-4.
1997: T I Prigozy; Peter Allan Sieling; D Clemens; P L Stewart; S M Behar; Steven A Porcelli; Michael B Brenner; Robert L Modlin; Mitchell Kronenberg
The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules.
Immunity 1997;6(2):187-97.
1997: D H Libraty; L E Airan; K Uyemura; D Jullien; Brad Spellberg; Thomas H Rea; Robert L Modlin
Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy.
The Journal of clinical investigation 1997;99(2):336-41.
1997: D Jullien; Peter Allan Sieling; K Uyemura; N D Mar; Thomas H Rea; Robert L Modlin
IL-15, an immunomodulator of T cell responses in intracellular infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):800-6.
1996: E M Beckman; A Melián; S M Behar; Peter Allan Sieling; D Chatterjee; Stephen T Furlong; R Matsumoto; Jean-Pierre Rosat; Robert L Modlin; Steven A Porcelli
CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):2795-803.
1996: Steven A Porcelli; Craig Morita; Robert L Modlin
T-cell recognition of non-peptide antigens.
Current opinion in immunology 1996;8(4):510-6.
1996: D Jullien; Laurent Brossay; Peter Allan Sieling; Robert L Modlin; Mitchell Kronenberg
CD1: clues on a new antigen-presenting pathway.
Research in immunology 1996;147(5):321-8.
1996: J H Gong; M Zhang; Robert L Modlin; P S Linsley; D Iyer; Y Lin; Peter F Barnes
Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression.
Infection and immunity 1996;64(3):913-8.
1996: J D Ohmen; Robert L Modlin
Evidence for a superantigen in the pathogenesis of tuberculosis.
Springer seminars in immunopathology 1996;17(4):375-84.
1996: P F Barnes; Robert L Modlin
Human cellular immune responses to Mycobacterium tuberculosis.
Current topics in microbiology and immunology 1996;215():197-219.
1995: Steven A Porcelli; Robert L Modlin
CD1 and the expanding universe of T cell antigens.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3709-10.
1995: Robert L Modlin; Peter F Barnes
IL12 and the human immune response to mycobacteria.
Research in immunology 1995;146(7-8):526-31.
1995: J Kim; Robert L Modlin; Ronald L Moy; Steven M Dubinett; T McHugh; B J Nickoloff; K Uyemura
IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):2240-7.
1995: Robert L Modlin
Cytokine responses in leprosy lesions.
Nihon Rai Gakkai zasshi 1995;64(2):85-8.
1995: Peter Allan Sieling; L Sakimura; K Uyemura; M Yamamura; J Oliveros; B J Nickoloff; Thomas H Rea; Robert L Modlin
IL-7 in the cell-mediated immune response to a human pathogen.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2775-83.
1994: M Zhang; J Gong; D V Iyer; B E Jones; Robert L Modlin; Peter F Barnes
T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection.
The Journal of clinical investigation 1994;94(6):2435-42.
1994: J D Ohmen; Ronald L Moy; D Zovich; A Lieberman; R J Wyzykowski; L Sullivan; Robert L Modlin; K Uyemura
Selective accumulation of T cells according to T-cell receptor V beta gene usage in skin cancer.
The Journal of investigative dermatology 1994;103(6):751-7.
1994: Peter Allan Sieling; Robert L Modlin
Cytokine patterns at the site of mycobacterial infection.
Immunobiology 1994;191(4-5):378-87.
1994: Y Tanaka; S Sano; Edward Nieves; G De Libero; D Rosa; Robert L Modlin; M B Brenner; Barry R Bloom; Craig Morita
Nonpeptide ligands for human gamma delta T cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8175-9.
1994: Peter Allan Sieling; Robert L Modlin
Regulation of cytokine patterns in leprosy.
Annals of the New York Academy of Sciences 1994;730():42-52.
1994: Robert L Modlin
Th1-Th2 paradigm: insights from leprosy.
The Journal of investigative dermatology 1994;102(6):828-32.
1994: M Zhang; M K Gately; E Wang; J Gong; Stanley Wolf; S Lu; Robert L Modlin; Peter F Barnes
Interleukin 12 at the site of disease in tuberculosis.
The Journal of clinical investigation 1994;93(4):1733-9.
1994: J D Ohmen; Peter F Barnes; C L Grisso; Barry R Bloom; Robert L Modlin
Evidence for a superantigen in human tuberculosis.
Immunity 1994;1(1):35-43.
1993: X Wang; L Golkar; K Uyemura; J D Ohmen; Laarni G Villahermosa; Tranquilino T Fajardo; Roland V Cellona; Gerald P Walsh; Robert L Modlin
T cells bearing V beta 6 T cell receptors in the cell-mediated immune response to Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7105-16.
1993: K Uyemura; Claude Pirmez; Peter Allan Sieling; K Kiene; M Paes-Oliveira; Robert L Modlin
CD4+ type 1 and CD8+ type 2 T cell subsets in human leishmaniasis have distinct T cell receptor repertoires.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7095-104.
1993: Robert L Modlin; Barry R Bloom
Immune regulation: learning from leprosy.
Hospital practice (Office ed.) 1993;28(11):71-4, 77-80, 83-4.
1993: K Uyemura; M Yamamura; D F Fivenson; Robert L Modlin; B J Nickoloff
The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response.
The Journal of investigative dermatology 1993;101(5):701-5.
1993: Peter F Barnes; S Lu; J S Abrams; E Wang; M Yamamura; Robert L Modlin
Cytokine production at the site of disease in human tuberculosis.
Infection and immunity 1993;61(8):3482-9.
1993: Robert L Modlin; T B Nutman
Type 2 cytokines and negative immune regulation in human infections.
Current opinion in immunology 1993;5(4):511-7.
1993: Peter Allan Sieling; J S Abrams; M Yamamura; P Salgame; Barry R Bloom; Thomas H Rea; Robert L Modlin
Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5501-10.
1993: Claude Pirmez; M Yamamura; K Uyemura; M Paes-Oliveira; F Conceição-Silva; Robert L Modlin
Cytokine patterns in the pathogenesis of human leishmaniasis.
The Journal of clinical investigation 1993;91(4):1390-5.
1993: M Yamamura; Robert L Modlin; J D Ohmen; Ronald L Moy
Local expression of antiinflammatory cytokines in cancer.
The Journal of clinical investigation 1993;91(3):1005-10.
1993: X H Wang; J D Ohmen; K Uyemura; Thomas H Rea; Mitchell Kronenberg; Robert L Modlin
Selection of T lymphocytes bearing limited T-cell receptor beta chains in the response to a human pathogen.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):188-92.
1993: Peter F Barnes; J S Abrams; S Lu; Peter Allan Sieling; Thomas H Rea; Robert L Modlin
Patterns of cytokine production by mycobacterium-reactive human T-cell clones.
Infection and immunity 1993;61(1):197-203.
1992: K Uyemura; C T Ho; J D Ohmen; Thomas H Rea; Robert L Modlin
Selective expansion of V delta 1 + T cells from leprosy skin lesions.
The Journal of investigative dermatology 1992;99(6):848-52.
1992: K Uyemura; J D Ohmen; C L Grisso; Peter Allan Sieling; R Wyzykowski; D M Reisinger; Thomas H Rea; Robert L Modlin
Limited T-cell receptor beta-chain diversity of a T-helper cell type 1-like response to Mycobacterium leprae.
Infection and immunity 1992;60(11):4542-8.
1992: M Yamamura; X H Wang; J D Ohmen; K Uyemura; Thomas H Rea; Barry R Bloom; Robert L Modlin
Cytokine patterns of immunologically mediated tissue damage.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(4):1470-5.
1992: Peter F Barnes; D Chatterjee; J S Abrams; S Lu; E Wang; M Yamamura; Patrick J Brennan; Robert L Modlin
Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):541-7.
1992: Peter F Barnes; D Chatterjee; Patrick J Brennan; Thomas H Rea; Robert L Modlin
Tumor necrosis factor production in patients with leprosy.
Infection and immunity 1992;60(4):1441-6.
1992: Peter F Barnes; V Mehra; B Rivoire; S J Fong; Patrick J Brennan; M S Voegtline; P Minden; R A Houghten; Barry R Bloom; Robert L Modlin
Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1835-40.
1992: Peter F Barnes; C L Grisso; J S Abrams; H Band; Thomas H Rea; Robert L Modlin
Gamma delta T lymphocytes in human tuberculosis.
The Journal of infectious diseases 1992;165(3):506-12.
1992: K Uyemura; J Klotz; Claude Pirmez; J Ohmen; X H Wang; C Ho; W L Hoffman; Robert L Modlin
Microanatomic clonality of gamma delta T cells in human leishmaniasis lesions.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):1205-11.
1992: Barry R Bloom; Robert L Modlin; P Salgame
Stigma variations: observations on suppressor T cells and leprosy.
Annual review of immunology 1992;10():453-88.
1992: Robert L Modlin; J Lewis; K Uyemura; R E Tigelaar
T lymphocytes bearing gamma-delta antigen receptors in skin.
Chemical immunology 1992;53():61-74.
1992: Peter Allan Sieling; Robert L Modlin
T cell and cytokine patterns in leprosy skin lesions.
Springer seminars in immunopathology 1992;13(3-4):413-26.
1992: P Salgame; M Yamamura; Barry R Bloom; Robert L Modlin
Evidence for functional subsets of CD4+ and CD8+ T cells in human disease: lymphokine patterns in leprosy.
Chemical immunology 1992;54():44-59.
1991: G Panchamoorthy; J McLean; Robert L Modlin; Craig Morita; S Ishikawa; Michael B Brenner; Hamid Band
A predominance of the T cell receptor V gamma 2/V delta 2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3360-9.
1991: J D Ohmen; Peter F Barnes; K Uyemura; S Z Lu; C L Grisso; Robert L Modlin
The T cell receptors of human gamma delta T cells reactive to Mycobacterium tuberculosis are encoded by specific V genes but diverse V-J junctions.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3353-9.
1991: L Sullivan; S Sano; C Pirmez; P Salgame; Christoph Mueller; Florence M Hofman; K Uyemura; Thomas H Rea; Barry R Bloom; Robert L Modlin
Expression of adhesion molecules in leprosy lesions.
Infection and immunity 1991;59(11):4154-60.
1991: M Yamamura; K Uyemura; R J Deans; K Weinberg; Thomas H Rea; Barry R Bloom; Robert L Modlin
Defining protective responses to pathogens: cytokine profiles in leprosy lesions.
Science (New York, N.Y.) 1991;254(5029):277-9.
1991: P Salgame; J S Abrams; C Clayberger; Harris Goldstein; Jacinto Convit; Robert L Modlin; Barry R Bloom
Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.
Science (New York, N.Y.) 1991;254(5029):279-82.
1991: Thomas H Rea; Robert L Modlin
Immunopathology of leprosy skin lesions.
Seminars in dermatology 1991;10(3):188-93.
1991: K Uyemura; R J Deans; Hamid Band; J Ohmen; G Panchamoorthy; Craig Morita; Thomas H Rea; Robert L Modlin
Evidence for clonal selection of gamma/delta T cells in response to a human pathogen.
The Journal of experimental medicine 1991;174(3):683-92.
1991: Hamid Band; Steven A Porcelli; G Panchamoorthy; J McLean; Craig Morita; S Ishikawa; Robert L Modlin; Michael B Brenner
Antigens and antigen-presenting molecules for gamma delta T cells.
Current topics in microbiology and immunology 1991;173():229-34.
1991: K Uyemura; Hamid Band; J Ohmen; Michael B Brenner; Thomas H Rea; Robert L Modlin
Gamma delta T cells in leprosy lesions.
Current topics in microbiology and immunology 1991;173():203-7.
1990: R Hershberg; P Eghtesady; Beate C Sydora; K Brorson; Hilde Cheroutre; Robert L Modlin; Mitchell Kronenberg
Expression of the thymus leukemia antigen in mouse intestinal epithelium.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9727-31.
1990: Claude Pirmez; C Cooper; M Paes-Oliveira; Armando Schubach; V K Torigian; Robert L Modlin
Immunologic responsiveness in American cutaneous leishmaniasis lesions.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):3100-4.
1990: Hamid Band; G Panchamoorthy; J Mclean; Craig Morita; S Ishikawa; Robert L Modlin; Michael B Brenner
Recognition of mycobacterial antigens by gamma delta T cells.
Research in immunology 1990;141(7):645-51.
1990: Peter F Barnes; S J Fong; Patrick J Brennan; P E Twomey; A Mazumder; Robert L Modlin
Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):149-54.
1990: V Mehra; Robert L Modlin
T-lymphocytes in leprosy lesions.
Current topics in microbiology and immunology 1990;155():97-109.
1989: Peter F Barnes; V Mehra; G R Hirschfield; S J Fong; C Abou-Zeid; Graham Rook; S W Hunter; Patrick J Brennan; Robert L Modlin
Characterization of T cell antigens associated with the cell wall protein-peptidoglycan complex of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(8):2656-62.
1989: L Wong; P Salgame; V K Torigian; T H Fu; Thomas H Rea; Robert L Modlin
CD2 expression and function in lepromatous leprosy.
Infection and immunity 1989;57(9):2815-9.
1989: John S Adams; Robert L Modlin; M M Diz; Peter F Barnes
Potentiation of the macrophage 25-hydroxyvitamin D-1-hydroxylation reaction by human tuberculous pleural effusion fluid.
The Journal of clinical endocrinology and metabolism 1989;69(2):457-60.
1989: Robert L Modlin; C Pirmez; Florence M Hofman; V Torigian; K Uyemura; Thomas H Rea; Barry R Bloom; M B Brenner
Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions.
Nature 1989;339(6225):544-8.
1989: Peter F Barnes; Robert L Modlin; Daniel David Bikle; John S Adams
Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis.
The Journal of clinical investigation 1989;83(5):1527-32.
1989: S W Hunter; Michael McNeil; Robert L Modlin; V Mehra; Barry R Bloom; Patrick J Brennan
Isolation and characterization of the highly immunogenic cell wall-associated protein of Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2864-72.
1989: Peter F Barnes; S D Mistry; C L Cooper; C Pirmez; Thomas H Rea; Robert L Modlin
Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(4):1114-9.
1989: Barry R Bloom; P Salgame; V Mehra; H Kato; Robert L Modlin; T Rea; P Brennan; Jacinto Convit; L Lugozi; S Snapper
Vaccine development. On relating immunology to the Third World: some studies on leprosy.
Immunology. Supplement 1989;2():87-9; discussion 91-2.
1989: P Salgame; Robert L Modlin; Barry R Bloom
On the mechanism of human T cell suppression.
International immunology 1989;1(2):121-9.
1989: Thomas H Rea; Robert L Modlin
Leprosy.
Immunology series 1989;46():723-45.
1988: Peter F Barnes; John Leedom; L S Chan; S F Wong; J Shah; Linda Vachon; G D Overturf; Robert L Modlin
Predictors of short-term prognosis in patients with pulmonary tuberculosis.
The Journal of infectious diseases 1988;158(2):366-71.
1988: J Melancon-Kaplan; S W Hunter; Michael McNeil; C Stewart; Robert L Modlin; Thomas H Rea; Jacinto Convit; P Salgame; V Mehra; Barry R Bloom
Immunological significance of Mycobacterium leprae cell walls.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1917-21.
1988: Robert L Modlin; J Melancon-Kaplan; S M Young; C Pirmez; H Kino; Jacinto Convit; Thomas H Rea; Barry R Bloom
Learning from lesions: patterns of tissue inflammation in leprosy.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1213-7.
1988: Robert L Modlin; Thomas H Rea
Immunopathology of leprosy granulomas.
Springer seminars in immunopathology 1988;10(4):359-74.
1988: Barry R Bloom; V Mehra; J Melancon-Kaplan; M Castes; Jacinto Convit; Patrick J Brennan; Thomas H Rea; Robert L Modlin
Mechanisms of immunological unresponsiveness in the spectra of leprosy and leishmaniasis.
Advances in experimental medicine and biology 1988;239():263-78.
1987: Robert L Modlin; M B Brenner; M S Krangel; A D Duby; Barry R Bloom
T-cell receptors of human suppressor cells.
Nature 1987;329(6139):541-5.
1987: J Y Shen; Florence M Hofman; J R Gunter; Robert L Modlin; Thomas H Rea
In situ identification of activated Ta1+ T lymphocytes in human leprosy skin lesions.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1987;55(3):494-8.
1987: M A Fullmer; J Y Shen; Robert L Modlin; Thomas H Rea
Immunohistological evidence of lymphokine production and lymphocyte activation antigens in tuberculin reactions.
Clinical and experimental immunology 1987;67(2):383-90.
1987: E E Nelson; L Wong; K Uyemura; Thomas H Rea; Robert L Modlin
Lepromin-induced suppressor cells in lepromatous leprosy.
Cellular immunology 1987;104(1):99-104.
1986: Robert L Modlin; G M Gersuk; E E Nelson; Paul K Pattengale; J R Gunter; L Chen; C L Cooper; Barry R Bloom; Thomas H Rea
T-lymphocyte clones from leprosy skin lesions.
Leprosy review 1986;57 Suppl 2():143-7.
1986: Robert L Modlin; V Mehra; L Wong; Yoshiaki Fujimiya; W C Chang; D A Horwitz; Barry R Bloom; Thomas H Rea; Paul K Pattengale
Suppressor T lymphocytes from lepromatous leprosy skin lesions.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(9):2831-4.
1986: Thomas H Rea; J Y Shen; Robert L Modlin
Epidermal keratinocyte Ia expression, Langerhans cell hyperplasia and lymphocytic infiltration in skin lesions of leprosy.
Clinical and experimental immunology 1986;65(2):253-9.
1986: Robert L Modlin; H Kato; V Mehra; E E Nelson; X D Fan; Thomas H Rea; Paul K Pattengale; Barry R Bloom
Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions.
Nature 1986;322(6078):459-61.
1985: Robert L Modlin; F J Tapia; Barry R Bloom; M E Gallinoto; M Castes; A J Rondon; Thomas H Rea; Jacinto Convit
In situ characterization of the cellular immune response in American cutaneous leishmaniasis.
Clinical and experimental immunology 1985;60(2):241-8.