Søren Moestrup

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Schlosser Anders; Thomsen Theresa; Moeller Jesper B; Nielsen Ole; Tornøe Ida; Mollenhauer Jan; Moestrup Søren K; Holmskov Uffe
Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin.
Nielsen Marianne Jensby; Moestrup Søren Kragh
Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging.
Vanhollebeke Benoit; De Muylder Géraldine; Nielsen Marianne J; Pays Annette; Tebabi Patricia; Dieu Marc; Raes Martine; Moestrup Soren K; Pays Etienne
A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Søren Moestrup (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Schlosser Anders; Thomsen Theresa; Moeller Jesper B; Nielsen Ole; Tornøe Ida; Mollenhauer Jan; Moestrup Søren K; Holmskov Uffe
Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3800-9.
2009: Nielsen Marianne Jensby; Moestrup Søren Kragh
Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging.
Blood 2009;114(4):764-71.
2008: Vanhollebeke Benoit; De Muylder Géraldine; Nielsen Marianne J; Pays Annette; Tebabi Patricia; Dieu Marc; Raes Martine; Moestrup Soren K; Pays Etienne
A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans.
Science (New York, N.Y.) 2008;320(5876):677-81.
2008: Gaïni S; Pedersen S S; Koldkaer O G; Pedersen C; Moestrup S K; Møller H J
New immunological serum markers in bacteraemia: anti-inflammatory soluble CD163, but not proinflammatory high mobility group-box 1 protein, is related to prognosis.
Clinical and experimental immunology 2008;151(3):423-31.
2008: Ambjørn Malene; Asmussen Johanne W; Lindstam Mats; Gotfryd Kamil; Jacobsen Christian; Kiselyov Vladislav V; Moestrup Søren K; Penkowa Milena; Bock Elisabeth; Berezin Vladimir
Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family.
Journal of neurochemistry 2008;104(1):21-37.
2007: Widener Justin; Nielsen Marianne Jensby; Shiflett April; Moestrup Søren Kragh; Hajduk Stephen
Hemoglobin is a co-factor of human trypanosome lytic factor.
PLoS pathogens 2007;3(9):1250-61.
2007: Levy Andrew P; Purushothaman K Raman; Levy Nina S; Purushothaman Meerarani; Strauss Merav; Asleh Rabea; Marsh Stuart; Cohen Osher; Moestrup Soren K; Moller Holger J; Zias Elias A; Benhayon Daniel; Fuster Valentin; Moreno Pedro R
Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.
Circulation research 2007;101(1):106-10.
2007: Fabriek Babs O; Polfliet Machteld M J; Vloet Rianka P M; van der Schors Roel C; Ligtenberg Antoon J M; Weaver Lehn K; Geest Christiaan; Matsuno Kenjiro; Moestrup Søren K; Dijkstra Christien D; van den Berg Timo K
The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor.
Blood 2007;109(12):5223-9.
2007: Vanhollebeke Benoit; Nielsen Marianne J; Watanabe Yoshihisa; Truc Philippe; Vanhamme Luc; Nakajima Kazunori; Moestrup Soren K; Pays Etienne
Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4118-23.
2007: Nielsen Marianne Jensby; Petersen Steen Vang; Jacobsen Christian; Thirup Søren; Enghild Jan Johannes; Graversen Jonas Heilskov; Moestrup Søren Kragh
A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.
The Journal of biological chemistry 2007;282(2):1072-9.
2007: Kronborg Camilla S; Knudsen Ulla Breth; Moestrup Søren K; Allen Jim; Vittinghus Erik; Møller Holger J
Serum markers of macrophage activation in pre-eclampsia: no predictive value of soluble CD163 and neopterin.
Acta obstetricia et gynecologica Scandinavica 2007;86(9):1041-6.
2006: Axelsson Jonas; Møller Holger Jon; Witasp Anna; Qureshi Abdul Rashid; Carrero Juan Jesus; Heimbürger Olof; Bárány Peter; Alvestrand Anders; Lindholm Bengt; Moestrup Søren K; Stenvinkel Peter
Changes in fat mass correlate with changes in soluble sCD163, a marker of mature macrophages, in patients with CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2006;48(6):916-25.
2006: Nielsen Lars B; Nielsen Marianne J; Moestrup Søren K
Lipid metabolism: an apolipoprotein-derived weapon combating trypanosoma infection.
Current opinion in lipidology 2006;17(6):699-701.
2006: Fedosov Sergey N; Grissom Charles B; Fedosova Natalya U; Moestrup Søren K; Nexø Ebba; Petersen Torben E
Application of a fluorescent cobalamin analogue for analysis of the binding kinetics. A study employing recombinant human transcobalamin and intrinsic factor.
The FEBS journal 2006;273(20):4742-53.
2006: Møller Holger Jon; Moestrup Søren K; Weis Nina; Wejse Christian; Nielsen Henrik; Pedersen Svend Stenvang; Attermann Jørn; Nexø Ebba; Kronborg Gitte
Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163.
Critical care medicine 2006;34(10):2561-6.
2006: Nielsen Marianne Jensby; Petersen Steen Vang; Jacobsen Christian; Oxvig Claus; Rees David; Møller Holger Jon; Moestrup Søren Kragh
Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.
Blood 2006;108(8):2846-9.
2006: Van den Steen Philippe E; Van Aelst Ilse; Hvidberg Vibeke; Piccard Helene; Fiten Pierre; Jacobsen Christian; Moestrup Soren K; Fry Simon; Royle Louise; Wormald Mark R; Wallis Russell; Rudd Pauline M; Dwek Raymond A; Opdenakker Ghislain
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
The Journal of biological chemistry 2006;281(27):18626-37.
2006: Theilgaard-Mönch Kim; Jacobsen Lars C; Nielsen Marianne J; Rasmussen Thomas; Udby Lene; Gharib Maged; Arkwright Peter D; Gombart Adrian F; Calafat Jero; Moestrup Søren K; Porse Bo T; Borregaard Niels
Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.
Blood 2006;108(1):353-61.
2006: Moestrup Søren K
New insights into carrier binding and epithelial uptake of the erythropoietic nutrients cobalamin and folate.
Current opinion in hematology 2006;13(3):119-23.
2006: Nielsen Marianne Jensby; Madsen Mette; Møller Holger J; Moestrup Søren K
The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants.
Journal of leukocyte biology 2006;79(4):837-45.
2006: Gaïni Shahin; Koldkjaer Ole G; Pedersen Svend S; Pedersen Court; Moestrup Søren K; Møller Holger J
Soluble haemoglobin scavenger receptor (sCD163) in patients with suspected community-acquired infections.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2006;114(2):103-11.
2006: Nielsen Lars B; Moestrup Søren Kragh
[Dyslipoproteinemia--a risk factor of both arterial and venous thrombosis?]
Ugeskrift for laeger 2006;168(8):802-3.
2006: Nielsen Lars B; Moestrup Søren K
Lipids metabolism: lipids and lipoproteins - effect on blood clotting and risk of venous thrombosis.
Current opinion in lipidology 2006;17(1):89-91.
2006: Aristoteli Lina Panayiota; Møller Holger Jon; Bailey Brian; Moestrup Søren Kragh; Kritharides Leonard
The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis.
Atherosclerosis 2006;184(2):342-7.
2006: Faber Kirsten; Hvidberg Vibeke; Moestrup Søren K; Dahlbäck Björn; Nielsen Lars Bo
Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.
Molecular endocrinology (Baltimore, Md.) 2006;20(1):212-8.
2006: Maniecki Maciej Bogdan; Møller Holger Jon; Moestrup Søren Kragh; Møller Bjarne Kuno
CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes.
Immunobiology 2006;211(6-8):407-17.
2005: Moestrup Søren Kragh; Møller Holger Jon
[The iron hormone hepcidin: A future diagnostic marker and therapeutic target in the treatment of anemia and hemochromatosis?]
Ugeskrift for laeger 2005;167(41):3894-5.
2005: Hvidberg Vibeke; Maniecki Maciej B; Jacobsen Christian; Højrup Peter; Møller Holger J; Moestrup Søren K
Identification of the receptor scavenging hemopexin-heme complexes.
Blood 2005;106(7):2572-9.
2005: Birn Henrik; Zhai Xiaoyue; Holm Jan; Hansen Steen I; Jacobsen Christian; Christensen Erik I; Moestrup Søren K
Megalin binds and mediates cellular internalization of folate binding protein.
The FEBS journal 2005;272(17):4423-30.
2005: Coudroy Gwénaëlle; Gburek Jakub; Kozyraki Renata; Madsen Mette; Trugnan Germain; Moestrup Søren K; Verroust Pierre J; Maurice Michèle
Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex.
Journal of the American Society of Nephrology : JASN 2005;16(8):2330-7.
2005: He Qianchuan; Madsen Mette; Kilkenney Adam; Gregory Brittany; Christensen Erik I; Vorum Henrik; Højrup Peter; Schäffer Alejandro A; Kirkness Ewen F; Tanner Stephan M; de la Chapelle Albert; Giger Urs; Moestrup Søren K; Fyfe John C
Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo.
Blood 2005;106(4):1447-53.
2005: Vogel Ida; Grove Jakob; Thorsen Poul; Moestrup Søren K; Uldbjerg Niels; Møller Holger Jon
Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery.
BJOG : an international journal of obstetrics and gynaecology 2005;112(6):737-42.
2005: Moestrup Søren K; Nielsen Lars Bo
The role of the kidney in lipid metabolism.
Current opinion in lipidology 2005;16(3):301-6.
2005: Funding Mikkel; Vorum Henrik; Nexø Ebba; Moestrup Søren Kragh; Ehlers Niels; Møller Holger Jon
Soluble CD163 and interleukin-6 are increased in aqueous humour from patients with endothelial rejection of corneal grafts.
Acta ophthalmologica Scandinavica 2005;83(2):234-9.
2005: Fagoonee Sharmila; Gburek Jakub; Hirsch Emilio; Marro Samuele; Moestrup Soren K; Laurberg Jacob M; Christensen Erik I; Silengo Lorenzo; Altruda Fiorella; Tolosano Emanuela
Plasma protein haptoglobin modulates renal iron loading.
The American journal of pathology 2005;166(4):973-83.
2005: Fedosov Sergey N; Fedosova Natalya U; Berglund Lars; Moestrup Søren K; Nexø Ebba; Petersen Torben E
Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor.
Biochemistry 2005;44(9):3604-14.
2005: Hvidberg Vibeke; Jacobsen Christian; Strong Roland K; Cowland Jack B; Moestrup Søren K; Borregaard Niels
The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake.
FEBS letters 2005;579(3):773-7.
2005: Schaer Dominik J; Schleiffenbaum Boris; Kurrer Michael; Imhof Alexander; Bächli Esther; Fehr Jörg; Moller Holger J; Moestrup Soren K; Schaffner Andreas
Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.
European journal of haematology 2005;74(1):6-10.
2004: Madsen Mette; Møller Holger J; Nielsen Marianne Jensby; Jacobsen Christian; Graversen Jonas H; van den Berg Timo; Moestrup Søren K
Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region.
The Journal of biological chemistry 2004;279(49):51561-7.
2004: Fedosov Sergey N; Fedosova Natalya U; Berglund Lars; Moestrup Søren K; Nexø Ebba; Petersen Torben E
Assembly of the intrinsic factor domains and oligomerization of the protein in the presence of cobalamin.
Biochemistry 2004;43(47):15095-102.
2004: Baeten Dominique; Møller Holger Jon; Delanghe Joris; Veys Eric M; Moestrup Søren K; De Keyser Filip
Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis.
Arthritis and rheumatism 2004;50(5):1611-23.
2004: Fyfe John C; Madsen Mette; Højrup Peter; Christensen Erik I; Tanner Stephan M; de la Chapelle Albert; He Qianchuan; Moestrup Søren K
The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.
Blood 2004;103(5):1573-9.
2004: Møller Holger Jon; de Fost Maaike; Aerts Hans; Hollak Carla; Moestrup Søren Kragh
Plasma level of the macrophage-derived soluble CD163 is increased and positively correlates with severity in Gaucher's disease.
European journal of haematology 2004;72(2):135-9.
2004: Moestrup Søren K; Møller Holger J
CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response.
Annals of medicine 2004;36(5):347-54.
2003: Horn Ivo R; Nielsen Marianne Jensby; Madsen Mette; Jacobsen Christian; Graversen Jonas Heilskov; Moestrup Søren K
Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163.
European journal of haematology 2003;71(4):289-93.
2003: Gburek Jakub; Birn Henrik; Verroust Pierre J; Goj Boguslawa; Jacobsen Christian; Moestrup Søren K; Willnow Thomas E; Christensen Erik I
Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.
American journal of physiology. Renal physiology 2003;285(3):F451-8.
2003: Fedosov Sergey N; Laursen Niels B; Nexø Ebba; Moestrup Søren K; Petersen Torben E; Jensen Erik Ø; Berglund Lars
Human intrinsic factor expressed in the plant Arabidopsis thaliana.
European journal of biochemistry / FEBS 2003;270(16):3362-7.
2003: Møller H J; Petersen P Hyltoft; Rejnmark L; Moestrup S K
Biological variation of soluble CD163.
Scandinavian journal of clinical and laboratory investigation 2003;63(1):15-21.
2002: Caterer Nigel R; Graversen Jonas H; Jacobsen Christian; Moestrup Søren K; Sigurskjold Bent W; Etzerodt Michael; Thøgersen Hans C
Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL.
Biological chemistry 2002;383(11):1743-50.
2002: Graversen Jonas Heilskov; Madsen Mette; Moestrup Søren K
CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.
The international journal of biochemistry & cell biology 2002;34(4):309-14.
2002: Birn Henrik; Willnow Thomas E; Nielsen Rikke; Norden Anthony G W; Bönsch Christian; Moestrup Søren K; Nexø Ebba; Christensen Erik I
Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).
American journal of physiology. Renal physiology 2002;282(3):F408-16.
2002: Gburek Jakub; Verroust Pierre J; Willnow Thomas E; Fyfe John C; Nowacki Wojciech; Jacobsen Christian; Moestrup Søren K; Christensen Erik I
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin.
Journal of the American Society of Nephrology : JASN 2002;13(2):423-30.
2002: Møller Holger Jon; Peterslund Niels Anker; Graversen Jonas Heilskov; Moestrup Søren Kragh
Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma.
Blood 2002;99(1):378-80.
2002: Norden Anthony G W; Lapsley Marta; Igarashi Takashi; Kelleher Catherine L; Lee Philip J; Matsuyama Takeshi; Scheinman Steven J; Shiraga Hiroshi; Sundin David P; Thakker Rajesh V; Unwin Robert J; Verroust Pierre; Moestrup Søren K
Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome.
Journal of the American Society of Nephrology : JASN 2002;13(1):125-33.
2002: Møller H J; Aerts H; Grønbaek H; Peterslund N A; Hyltoft Petersen P; Hornung N; Rejnmark L; Jabbarpour E; Moestrup S K
Soluble CD163: a marker molecule for monocyte/macrophage activity in disease.
Scandinavian journal of clinical and laboratory investigation. Supplementum 2002;237():29-33.
2002: Møller H J; Hald K; Moestrup S K
Characterization of an enzyme-linked immunosorbent assay for soluble CD163.
Scandinavian journal of clinical and laboratory investigation 2002;62(4):293-9.
2001: Andersen O M; Schwarz F P; Eisenstein E; Jacobsen C; Moestrup S K; Etzerodt M; Thøgersen H C
Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP.
Biochemistry 2001;40(50):15408-17.
2001: Nykjaer A; Fyfe J C; Kozyraki R; Leheste J R; Jacobsen C; Nielsen M S; Verroust P J; Aminoff M; de la Chapelle A; Moestrup S K; Ray R; Gliemann J; Willnow T E; Christensen E I
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13895-900.
2001: Kozyraki R; Fyfe J; Verroust P J; Jacobsen C; Dautry-Varsat A; Gburek J; Willnow T E; Christensen E I; Moestrup S K
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12491-6.
2001: Andersen O M; Petersen H H; Jacobsen C; Moestrup S K; Etzerodt M; Andreasen P A; Thøgersen H C
Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein.
The Biochemical journal 2001;357(Pt 1):289-96.
2001: Kristiansen M; Graversen J H; Jacobsen C; Sonne O; Hoffman H J; Law S K; Moestrup S K
Identification of the haemoglobin scavenger receptor.
Nature 2001;409(6817):198-201.
2001: Madsen M; Graversen J H; Moestrup S K
Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes.
Redox report : communications in free radical research 2001;6(6):386-8.
2001: Moestrup S K; Verroust P J
Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia.
Annual review of nutrition 2001;21():407-28.
2000: Sousa M M; Norden A G; Jacobsen C; Willnow T E; Christensen E I; Thakker R V; Verroust P J; Moestrup S K; Saraiva M J
Evidence for the role of megalin in renal uptake of transthyretin.
The Journal of biological chemistry 2000;275(49):38176-81.
2000: Graversen J H; Jacobsen C; Sigurskjold B W; Lorentsen R H; Moestrup S K; Thogersen H C; Etzerodt M
Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold.
The Journal of biological chemistry 2000;275(48):37390-6.
2000: Zhai X Y; Nielsen R; Birn H; Drumm K; Mildenberger S; Freudinger R; Moestrup S K; Verroust P J; Christensen E I; Gekle M
Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.
Kidney international 2000;58(4):1523-33.
2000: Andersen O M; Christensen P A; Christensen L L; Jacobsen C; Moestrup S K; Etzerodt M; Thogersen H C
Specific binding of alpha-macroglobulin to complement-type repeat CR4 of the low-density lipoprotein receptor-related protein.
Biochemistry 2000;39(35):10627-33.
2000: Kristiansen M; Aminoff M; Jacobsen C; de La Chapelle A; Krahe R; Verroust P J; Moestrup S K
Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin.
Blood 2000;96(2):405-9.
2000: Andersen O M; Christensen L L; Christensen P A; Sørensen E S; Jacobsen C; Moestrup S K; Etzerodt M; Thogersen H C
Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP.
The Journal of biological chemistry 2000;275(28):21017-24.
2000: Moestrup S K
[The iron gate is open--by a transparent zebrafish]
Ugeskrift for laeger 2000;162(25):3619.
2000: Birn H; Fyfe J C; Jacobsen C; Mounier F; Verroust P J; Orskov H; Willnow T E; Moestrup S K; Christensen E I
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
The Journal of clinical investigation 2000;105(10):1353-61.
2000: Moestrup S K; Kozyraki R
Cubilin, a high-density lipoprotein receptor.
Current opinion in lipidology 2000;11(2):133-40.
2000: Birn H; Vorum H; Verroust P J; Moestrup S K; Christensen E I
Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules.
Journal of the American Society of Nephrology : JASN 2000;11(2):191-202.
2000: Verroust P J; Kozyraki R; Hammond T G; Moestrup S K; Christensen E I
Physiopathologic role of cubilin and megalin.
Advances in nephrology from the Necker Hospital 2000;30():127-45.
1999: Kristiansen M; Kozyraki R; Jacobsen C; Nexø E; Verroust P J; Moestrup S K
Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding.
The Journal of biological chemistry 1999;274(29):20540-4.
1999: Kozyraki R; Fyfe J; Kristiansen M; Gerdes C; Jacobsen C; Cui S; Christensen E I; Aminoff M; de la Chapelle A; Krahe R; Verroust P J; Moestrup S K
The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
Nature medicine 1999;5(6):656-61.
1999: Christensen E I; Moskaug J O; Vorum H; Jacobsen C; Gundersen T E; Nykjaer A; Blomhoff R; Willnow T E; Moestrup S K
Evidence for an essential role of megalin in transepithelial transport of retinol.
Journal of the American Society of Nephrology : JASN 1999;10(4):685-95.
1999: Aminoff M; Carter J E; Chadwick R B; Johnson C; Gräsbeck R; Abdelaal M A; Broch H; Jenner L B; Verroust P J; Moestrup S K; de la Chapelle A; Krahe R
Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.
Nature genetics 1999;21(3):309-13.
1999: Munck Petersen C; Nielsen M S; Jacobsen C; Tauris J; Jacobsen L; Gliemann J; Moestrup S K; Madsen P
Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.
The EMBO journal 1999;18(3):595-604.
1998: Horn I R; van den Berg B M; Moestrup S K; Pannekoek H; van Zonneveld A J
Plasminogen activator inhibitor 1 contains a cryptic high affinity receptor binding site that is exposed upon complex formation with tissue-type plasminogen activator.
Thrombosis and haemostasis 1998;80(5):822-8.
1998: Graversen J H; Lorentsen R H; Jacobsen C; Moestrup S K; Sigurskjold B W; Thogersen H C; Etzerodt M
The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine.
The Journal of biological chemistry 1998;273(44):29241-6.
1998: Nielsen R; Birn H; Moestrup S K; Nielsen M; Verroust P; Christensen E I
Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin.
Journal of the American Society of Nephrology : JASN 1998;9(10):1767-76.
1998: Moestrup S K; Schousboe I; Jacobsen C; Leheste J R; Christensen E I; Willnow T E
beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin.
The Journal of clinical investigation 1998;102(5):902-9.
1998: Tauris J; Ellgaard L; Jacobsen C; Nielsen M S; Madsen P; Thøgersen H C; Gliemann J; Petersen C M; Moestrup S K
The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin.
FEBS letters 1998;429(1):27-30.
1998: Kozyraki R; Kristiansen M; Silahtaroglu A; Hansen C; Jacobsen C; Tommerup N; Verroust P J; Moestrup S K
The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region.
Blood 1998;91(10):3593-600.
1998: Christensen E I; Birn H; Verroust P; Moestrup S K
Megalin-mediated endocytosis in renal proximal tubule.
Renal failure 1998;20(2):191-9.
1998: Moestrup S K; Kozyraki R; Kristiansen M; Kaysen J H; Rasmussen H H; Brault D; Pontillon F; Goda F O; Christensen E I; Hammond T G; Verroust P J
The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.
The Journal of biological chemistry 1998;273(9):5235-42.
1998: Hartmann R; Norby P L; Martensen P M; Jorgensen P; James M C; Jacobsen C; Moestrup S K; Clemens M J; Justesen J
Activation of 2'-5' oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers.
The Journal of biological chemistry 1998;273(6):3236-46.
1998: Christensen E I; Birn H; Verroust P; Moestrup S K
Membrane receptors for endocytosis in the renal proximal tubule.
International review of cytology 1998;180():237-84.
1997: Petersen C M; Nielsen M S; Nykjaer A; Jacobsen L; Tommerup N; Rasmussen H H; Roigaard H; Gliemann J; Madsen P; Moestrup S K
Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.
The Journal of biological chemistry 1997;272(6):3599-605.
1996: Jacobsen L; Madsen P; Moestrup S K; Lund A H; Tommerup N; Nykjaer A; Sottrup-Jensen L; Gliemann J; Petersen C M
Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.
The Journal of biological chemistry 1996;271(49):31379-83.
1996: Cui S; Verroust P J; Moestrup S K; Christensen E I
Megalin/gp330 mediates uptake of albumin in renal proximal tubule.
The American journal of physiology 1996;271(4 Pt 2):F900-7.
1996: Petersen C M; Ellgaard L; Nykjaer A; Vilhardt F; Vorum H; Thøgersen H C; Nielsen M S; Jacobsen C; Moestrup S K; Gliemann J
The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II.
The EMBO journal 1996;15(16):4165-73.
1996: Moestrup S K; Birn H; Fischer P B; Petersen C M; Verroust P J; Sim R B; Christensen E I; Nexø E
Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8612-7.
1996: Nielsen K L; Holtet T L; Etzerodt M; Moestrup S K; Gliemann J; Sottrup-Jensen L; Thogersen H C
Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1996;271(22):12909-12.
1995: Moestrup S K; Cui S; Vorum H; Bregengård C; Bjørn S E; Norris K; Gliemann J; Christensen E I
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
The Journal of clinical investigation 1995;96(3):1404-13.
1995: Horn I R; Moestrup S K; van den Berg B M; Pannekoek H; Nielsen M S; van Zonneveld A J
Analysis of the binding of pro-urokinase and urokinase-plasminogen activator inhibitor-1 complex to the low density lipoprotein receptor-related protein using a Fab fragment selected from a phage-displayed Fab library.
The Journal of biological chemistry 1995;270(20):11770-5.
1995: Christensen E I; Nielsen S; Moestrup S K; Borre C; Maunsbach A B; de Heer E; Ronco P; Hammond T G; Verroust P
Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules.
European journal of cell biology 1995;66(4):349-64.
1995: Ellgaard L; Holtet T L; Moestrup S K; Etzerodt M; Thøgersen H C
Nested sets of protein fragments and their use in epitope mapping: characterization of the epitope for the S4D5 monoclonal antibody binding to receptor associated protein.
Journal of immunological methods 1995;180(1):53-61.
1994: Gliemann J; Nykjaer A; Petersen C M; Jørgensen K E; Nielsen M; Andreasen P A; Christensen E I; Lookene A; Olivecrona G; Moestrup S K
The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.
Annals of the New York Academy of Sciences 1994;737():20-38.
1994: Holtet T L; Nielsen K L; Etzerodt M; Moestrup S K; Gliemann J; Sottrup-Jensen L; Thøgersen H C
Recombinant alpha 2M receptor binding domain binds to the alpha 2M receptor with high affinity.
Annals of the New York Academy of Sciences 1994;737():480-2.
1994: Moestrup S K; Christensen E I; Nielsen S; Jørgensen K E; Bjørn S E; Røigaard H; Gliemann J
Binding and endocytosis of proteins mediated by epithelial gp330.
Annals of the New York Academy of Sciences 1994;737():124-37.
1994: Moestrup S K
The alpha 2-macroglobulin receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands.
Biochimica et biophysica acta 1994;1197(2):197-213.
1994: Holtet T L; Nielsen K L; Etzerodt M; Moestrup S K; Gliemann J; Sottrup-Jensen L; Thøgersen H C
Receptor-binding domain of human alpha 2-macroglobulin. Expression, folding and biochemical characterization of a high-affinity recombinant derivative.
FEBS letters 1994;344(2-3):242-6.
1994: Andreasen P A; Sottrup-Jensen L; Kjøller L; Nykjaer A; Moestrup S K; Petersen C M; Gliemann J
Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes.
FEBS letters 1994;338(3):239-45.
1993: Gliemann J; Nykjaer A; Jensen P H; Moestrup S K
[Complement activation caused by beta-amyloid in Alzheimer's dementia]
Ugeskrift for laeger 1993;155(39):3135-6.
1993: Moestrup S K; Nielsen S; Andreasen P; Jørgensen K E; Nykjaer A; Røigaard H; Gliemann J; Christensen E I
Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes.
The Journal of biological chemistry 1993;268(22):16564-70.
1993: Nykjaer A; Bengtsson-Olivecrona G; Lookene A; Moestrup S K; Petersen C M; Weber W; Beisiegel U; Gliemann J
The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase.
The Journal of biological chemistry 1993;268(20):15048-55.
1993: Moestrup S K; Holtet T L; Etzerodt M; Thøgersen H C; Nykjaer A; Andreasen P A; Rasmussen H H; Sottrup-Jensen L; Gliemann J
Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats.
The Journal of biological chemistry 1993;268(18):13691-6.
1993: Gliemann J; Nykjaer A; Jensen P H; Moestrup S K
[Low density lipoprotein (LDL) receptor-related protein internalizes and degrades uPA-PA1 complexes and is essential for embryo implantation]
Ugeskrift for laeger 1993;155(13):981.
1992: Christensen E I; Gliemann J; Moestrup S K
Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(10):1481-90.
1992: Moestrup S K; Gliemann J; Pallesen G
Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues.
Cell and tissue research 1992;269(3):375-82.
1992: Nykjaer A; Petersen C M; Møller B; Jensen P H; Moestrup S K; Holtet T L; Etzerodt M; Thøgersen H C; Munch M; Andreasen P A
Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.
The Journal of biological chemistry 1992;267(21):14543-6.
1992: Moestrup S K; Hokland P
Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells.
Leukemia research 1992;16(3):227-34.
1991: Moestrup S K; Gliemann J
Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein). Evidence that high affinity of alpha 2-macroglobulin-proteinase complex is achieved by binding to adjacent receptors.
The Journal of biological chemistry 1991;266(21):14011-7.
1990: Petersen C M; Moestrup S K
Interactions between cytokines and alpha 2 macroglobulin.
Immunology today 1990;11(12):430-1.
1990: Kristensen T; Moestrup S K; Gliemann J; Bendtsen L; Sand O; Sottrup-Jensen L
Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor.
FEBS letters 1990;276(1-2):151-5.
1990: Moestrup S K; Kaltoft K; Petersen C M; Pedersen S; Gliemann J; Christensen E I
Immunocytochemical identification of the human alpha 2-macroglobulin receptor in monocytes and fibroblasts: monoclonal antibodies define the receptor as a monocyte differentiation antigen.
Experimental cell research 1990;190(2):195-203.
1990: Munck Petersen C; Davidsen O; Moestrup S K; Sonne O; Nykjaer A; Møller B K
Cellular targets and receptors for interleukin-6. II. Characterization of IL-6 binding and receptors in peripheral blood cells and macrophages.
European journal of clinical investigation 1990;20(4):377-84.
1990: Moestrup S K; Kaltoft K; Sottrup-Jensen L; Gliemann J
The human alpha 2-macroglobulin receptor contains high affinity calcium binding sites important for receptor conformation and ligand recognition.
The Journal of biological chemistry 1990;265(21):12623-8.
1989: Jensen P H; Moestrup S K; Gliemann J
Purification of the human placental alpha 2-macroglobulin receptor.
FEBS letters 1989;255(2):275-80.
1989: Moestrup S K; Gliemann J
Purification of the rat hepatic alpha 2-macroglobulin receptor as an approximately 440-kDa single chain protein.
The Journal of biological chemistry 1989;264(26):15574-7.
1989: Gliemann J; Davidsen O; Moestrup S K
Characterization, size estimation and solubilization of alpha-macroglobulin complex receptors in liver membranes.
Biochimica et biophysica acta 1989;980(3):326-32.
1989: Petersen C M; Ejlersen E; Moestrup S K; Jensen P H; Sand O; Sottrup-Jensen L
Immunosuppressive properties of electrophoretically "slow" and "fast" form alpha 2-macroglobulin. Effects on cell-mediated cytotoxicity and (allo-) antigen-induced T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):629-35.
1988: Jensen P H; Moestrup S K; Sottrup-Jensen L; Petersen C M; Gliemann J
Receptors for alpha 2-macroglobulin- and pregnancy zone protein-proteinase complexes in the human placental syncytiotrophoblast.
Placenta 1988;9(5):463-77.
1988: Petersen C M; Christiansen B S; Jensen P H; Moestrup S K; Gliemann J; Sottrup-Jensen L; Ingerslev J
Human hepatocytes exhibit receptors for alpha 2-macroglobulin and pregnancy zone protein-proteinase complexes.
European journal of clinical investigation 1988;18(2):184-90.
1987: Moestrup S K; Christensen E I; Sottrup-Jensen L; Gliemann J
Binding and receptor-mediated endocytosis of pregnancy zone protein-proteinase complex in rat macrophages.
Biochimica et biophysica acta 1987;930(3):297-303.
1986: Gliemann J; Moestrup S; Henning Jensen P; Sottrup-Jensen L; Busk Andersen H; Munck Petersen C; Sonne O
Evidence for binding of human pregnancy zone protein-proteinase complex to alpha 2-macroglobulin receptors.
Biochimica et biophysica acta 1986;883(3):400-6.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Søren Moestrup

Research Profile (preview)

Chemicals & Drugs

Physiology

Phenomena

Living Beings

Genes & Molecular Sequences

Anatomy

Concepts & Ideas

Procedures

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Søren Moestrup (preview)

All Publications