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Ramzi Mohammad

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TOP 3
Osama M Alian; Momin Mohammad; Minjel Shah; Ramzi M Mohammad
Network pharmacology: reigning in drug attrition?
Asfar S Azmi; Ginny W Bao; Jiankun Gao; Ramzi M Mohammad; Fazlul H Sarkar
Network insights into the genes regulated by hepatocyte nuclear factor 4 in response to drug induced perturbations: a review.
Asfar S Azmi; Ramzi M Mohammad; Fazlul H Sarkar
Can network pharmacology rescue neutraceutical cancer research?

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All Publications

2013: Osama M Alian; Momin Mohammad; Minjel Shah; Ramzi M Mohammad
Network pharmacology: reigning in drug attrition?
Current drug discovery technologies 2013;10(2):155-9.
2013: Asfar S Azmi; Ginny W Bao; Jiankun Gao; Ramzi M Mohammad; Fazlul H Sarkar
Network insights into the genes regulated by hepatocyte nuclear factor 4 in response to drug induced perturbations: a review.
Current drug discovery technologies 2013;10(2):147-54.
2012: Asfar S Azmi; Ramzi M Mohammad; Fazlul H Sarkar
Can network pharmacology rescue neutraceutical cancer research?
Drug discovery today 2012;17(15-16):807-9.
2012: Ramazan Ulu; Mehmet Tuzcu; Mustafa Ulas; Ayhan Dogukan; hasan gencoglu; Necip Ilhan; Omer Kucuk; Ramzi M Mohammad; Irfana Muqbil; Kazim Sahin
Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(5):1675-9.
2012: Uzma Shamim; Sheikh M Hadi; Sarmad Hanif; Fazlul H Sarkar; Bin Bao; Abdulmajeed Albanyan; Ramzi M Mohammad; Zhiwei Wang; Frances W J Beck; Sanjeev Banerjee; Asfar S Azmi
Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer.
Journal of cellular physiology 2012;227(4):1493-500.
2012: Osama M Alian; Asfar S Azmi; Ramzi M Mohammad
Network insights on oxaliplatin anti-cancer mechanisms.
Clinical and translational medicine 2012;1(1):26.
2012: Guan Wang; Chengzhi Xie; Wenting Yun; Jianyun Zhao; Yingjie Guo; Jing He; Wei Kong; Ramzi M Mohammad; Jeffrey W Taub; ASFAR AZMI; Yan Dong; Yubin Ge
Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer.
PloS one 2012;7(12):e52095.
2012: Saba Haq; Ramzi M Mohammad; Shadan Ali; Fazlul H Sarkar
The complexities of epidemiology and prevention of gastrointestinal cancers.
International journal of molecular sciences 2012;13(10):12556-72.
2012: Angela M Sosin; Judith Abrams; Angelika Burger; Ramzi M Mohammad; Aisha Siddiqi; Ayad Al-Katib
HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas.
Journal of hematology & oncology 2012;5():57.
2012: Irfana Muqbil; Fazlul H Sarkar; Bin Bao; Frances W J Beck; S M Hadi; Ramzi M Mohammad; Asfar S Azmi
Old wine in a new bottle: the Warburg effect and anticancer mechanisms of resveratrol.
Current pharmaceutical design 2012;18(12):1645-54.
2011: Asfar S Azmi; Bin Bao; Frances W J Beck; Ramzi M Mohammad; Fazlul H Sarkar
Aberrant epigenetic grooming of miRNAs in pancreatic cancer: a systems biology perspective.
Epigenomics 2011;3(6):747-59.
2011: Asfar S Azmi; Sanjeev Banerjee; Bin Bao; Mai N Maitah; Ramzi M Mohammad; Subhash Padhye; Philip A Philip; Shadan Ali; Fazlul H Sarkar
Network modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism.
American journal of translational research 2011;3(4):374-82.
2011: Edi Levi; Liyue Zhang; Amro Aboukameel; Sunny Rishi; Ramzi M Mohammad; Lisa Anne Polin ; James S Hatfield; Arun K Rishi
Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel, adriamycin-inducible, diffuse large B-cell lymphoma (DLBL) growth suppressor.
Cancer chemotherapy and pharmacology 2011;67(6):1401-13.
2011: Asfar S Azmi; Sanjeev Banerjee; Bin Bao; Frances W J Beck; Minsig Choi; Main Maitah; Philip A Philip; Fazlul H Sarkar; Tony F Shields; Zhiwei Wang; Shadan Ali; Ramzi M Mohammad
Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors.
Oncotarget 2011;2(5):378-92.
2011: ASFAR AZMI; Zhiwei Wang; Philip A Philip; Ramzi M Mohammad; Asfar S Azmi
Emerging Bcl-2 inhibitors for the treatment of cancer.
Expert opinion on emerging drugs 2011;16(1):59-70.
2011: Asfar S Azmi; Philip A Philip; F W J Beck; Z Wang; S Banerjee; Shaomeng Wang; D Yang; Fazlul H Sarkar; Ramzi M Mohammad
MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy.
Oncogene 2011;30(1):117-26.
2011: Zhiwei Wang; Aamir Ahmad; Shadan Ali; Asfar S Azmi; Sanjeev Banerjee; Bin Bao; Jiankun Gao; Jason R Gunn; Dejuan Kong; Murray Korc; Yiwei Li; Lucio Miele; Ramzi M Mohammad; Fazlul H Sarkar
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways.
PloS one 2011;6(6):e20537.
2011: ASFAR AZMI; Frances W J Beck; Asfar S Azmi; Ramzi M Mohammad
Network perspectives on HDM2 inhibitor chemotherapy combinations.
Current pharmaceutical design 2011;17(6):640-52.
2010: ASFAR AZMI; Zhiwei Wang; Philip A Philip; Ramzi M Mohammad; Asfar S Azmi
Proof of concept: network and systems biology approaches aid in the discovery of potent anticancer drug combinations.
Molecular cancer therapeutics 2010;9(12):3137-44.
2010: Lulu Farhana; Marcia I Dawson; Zebin Xia; Amro Aboukameel; Liping Xu; Gang Liu; Jayanta K Das; James Hatfield; Edi Levi; Ramzi M Mohammad; Joseph A Fontana
Adamantyl-substituted retinoid-related molecules induce apoptosis in human acute myelogenous leukemia cells.
Molecular cancer therapeutics 2010;9(11):2903-13.
2010: Jyoti Nautiyal; Yingjie Yu; Amro Aboukameel; Shailender S Kanwar; Jayanta K Das; Jianhua Du; Bhaumik B Patel; Asfar S Azmi; Arun K Rishi; Ramzi M Mohammad; Adhip N Majumdar
ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cells.
Molecular cancer therapeutics 2010;9(6):1503-14.
2010: ASFAR AZMI; Philip A Philip; Syed F Zafar; Asfar S Azmi; Ramzi M Mohammad
PAR-4 as a possible new target for pancreatic cancer therapy.
Expert opinion on therapeutic targets 2010;14(6):611-20.
2010: Sanjeev Banerjee; ASFAR AZMI; Subhash Padhye; Marjit W Singh; Jubaraj B Baruah; Philip A Philip; Asfar S Azmi; Ramzi M Mohammad
Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.
Pharmaceutical research 2010;27(6):1146-58.
2010: ASFAR AZMI; Philip A Philip; Khaldoun Almhanna; Frances W Beck; Asfar S Azmi; Ramzi M Mohammad
MDM2 inhibitors for pancreatic cancer therapy.
Mini reviews in medicinal chemistry 2010;10(6):518-26.
2010: ASFAR AZMI; Philip A Philip; Amro Aboukameel; Zhiwei Wang; Sanjeev Banerjee; Syed F Zafar; Anton Goustin; Khaldoun Almhanna; Dajun Yang; Asfar S Azmi; Ramzi M Mohammad
Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy.
Current cancer drug targets 2010;10(3):319-31.
2010: ASFAR AZMI; Amro Aboukameel; Sanjeev Banerjee; Zhiwei Wang; Momin Mohammad; Jack Wu; Shaomeng Wang; Dajun Yang; Philip A Philip; Asfar S Azmi; Ramzi M Mohammad
MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function.
European journal of cancer (Oxford, England : 1990) 2010;46(6):1122-31.
2010: Sanjeev Banerjee; Minsig Choi; Amro Aboukameel; Zhiwei Wang; Mussop Mohammad; Jianyong Chen; Dajun Yang; Asfar S Azmi; Ramzi M Mohammad
Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells.
Pancreas 2010;39(3):323-31.
2010: Sanjeev Banerjee; Subhash Padhye; ASFAR AZMI; Zhiwei Wang; Philip A Philip; Omer Kucuk; Asfar S Azmi; Ramzi M Mohammad
Review on molecular and therapeutic potential of thymoquinone in cancer.
Nutrition and cancer 2010;62(7):938-46.
2010: Ayad Al-Katib; Alan A Arnold; Amro Aboukameel; Angela Sosin; Peter Smith; Anwar N Mohamed; Frances W J Beck; Ramzi M Mohammad
I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma.
Molecular cancer 2010;9():228.
2009: NAZEEM SHAMSUDDIN; ASFAR AZMI; SARMAD HANIF; Aamir Ahmad; Ramzi M Mohammad; Sheikh Mumtaz Hadi; K Sateesh Kumar
Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells.
Mutagenesis 2009;24(5):413-8.
2009: Sanjeev Banerjee; Ahmed O Kaseb; Zhiwei Wang; Deujan Kong; Mussop Mohammad; Subhash Padhye; Asfar S Azmi; Ramzi M Mohammad
Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer.
Cancer research 2009;69(13):5575-83.
2009: Ayad Al-Katib; Amro Aboukameel; Ramzi M Mohammad; MC Bissery; Claudia Zuany-Amorim
Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4038-45.
2009: Zhiwei Wang; ASFAR AZMI; Aamir Ahmad; Sanjeev Banerjee; Shaomeng Wang; Asfar S Azmi; Ramzi M Mohammad
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway.
Cancer research 2009;69(7):2757-65.
2009: Nishant Tageja; Subhash Padheye; Prasad Dandawate; Ayad Al-Katib; Ramzi M Mohammad
New targets for the treatment of follicular lymphoma.
Journal of hematology & oncology 2009;2():50.
2009: Ramzi M Mohammad; Jack Wu; ASFAR AZMI; Amro Aboukameel; Angela Sosin; Sherwin Wu; Dajun Yang; Shaomeng Wang; Ayad Al-Katib
An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals.
Molecular cancer 2009;8():115.
2009: Ayad Al-Katib; Yuan Sun; Anton Goustin; ASFAR AZMI; Ben D Chen; Amro Aboukameel; Ramzi M Mohammad
SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status.
Journal of hematology & oncology 2009;2():8.
2009: ASFAR AZMI; Ramzi M Mohammad
Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.
Journal of cellular physiology 2009;218(1):13-21.
2008: ASFAR AZMI; Zhiwei Wang; Ravshan Burikhanov; Vivek M Rangnekar; Guoping Wang; Jianyong Chen; Shaomeng Wang; Asfar S Azmi; Ramzi M Mohammad
Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis.
Molecular cancer therapeutics 2008;7(9):2884-93.
2008: Yuan Sun; Jack Wu; Amro Aboukameel; Sanjeev Banerjee; Alan A Arnold; Jianyong Chen; Zaneta Nikolovska-Coleska; Yanqiong Lin; Xiaolan Ling; Dajun Yang; Shaomeng Wang; Ayad Al-Katib; Ramzi M Mohammad
Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.
Cancer biology & therapy 2008;7(9):1418-26.
2008: ASFAR AZMI; Aamir Ahmad; Sanjeev Banerjee; Vivek M Rangnekar; Ramzi M Mohammad; Asfar S Azmi
Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM).
Pharmaceutical research 2008;25(9):2117-24.
2008: Zhiwei Wang; Wen Song; Amro Aboukameel; Mussop Mohammad; Guoping Wang; Sanjeev Banerjee; Dejuan Kong; Shaomeng Wang; Asfar S Azmi; Ramzi M Mohammad
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer.
International journal of cancer. Journal international du cancer 2008;123(4):958-66.
2008: Sanjeev Banerjee; Zhiwei Wang; Mussop Mohammad; Asfar S Azmi; Ramzi M Mohammad
Efficacy of selected natural products as therapeutic agents against cancer.
Journal of natural products 2008;71(3):492-6.
2008: Ramzi M Mohammad; Anshu Giri; Anton Goustin
Small-molecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer.
Recent patents on anti-cancer drug discovery 2008;3(1):20-30.
2008: Alan A Arnold; Amro Aboukameel; Jianyong Chen; Dajun Yang; Shaomeng Wang; Ayad Al-Katib; Ramzi M Mohammad
Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model.
Molecular cancer 2008;7():20.
2007: Manchao Zhang; Yan Ling; Chao-Yie Yang; Hongpeng Liu; Renxiao Wang; Xihan Wu; Ke Ding; Feng Zhu; Brian N Griffith; Ramzi M Mohammad; Shaomeng Wang; Dajun Yang
A novel Bcl-2 small molecule inhibitor 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB)-induced apoptosis in leukemia cells.
Annals of hematology 2007;86(7):471-81.
2007: Liyue Zhang; Edi Levi; Pralay Majumder; Yingjie Yu; Amro Aboukameel; Jianhua Du; Hu Xu; Ramzi M Mohammad; James S Hatfield; Anil Wali; Volkan Adsay; Adhip N Majumdar; Arun K Rishi
Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo.
Molecular cancer therapeutics 2007;6(5):1661-72.
2007: Ramzi M Mohammad; Anton Goustin; Amro Aboukameel; Ben D Chen; Sanjeev Banerjee; Guoping Wang; Zaneta Nikolovska-Coleska; Shaomeng Wang; Ayad Al-Katib
Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2226-35.
2006: Zhiwei Wang; Radha Sengupta; Sanjeev Banerjee; Yiwei Li; Yuxiang Zhang; K M Wahidur Rahman; Amro Aboukameel; Ramzi M Mohammad; Adhip N Majumdar; James L Abbruzzese; Asfar S Azmi
Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer.
Cancer research 2006;66(15):7653-60.
2006: Ramzi M Mohammad; Sanjeev Banerjee; Yiwei Li; Amro Aboukameel; Omer Kucuk; Asfar S Azmi
Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts.
Cancer 2006;106(6):1260-8.
2006: Mingjun Liu; Yubin Ge; Scott G Payton; Amro Aboukameel; Stephen Buck; Robin M Flatley; Christina L Haska; Ramzi M Mohammad; Jeffrey W Taub; Larry H Matherly
Transcriptional regulation of the human reduced folate carrier in childhood acute lymphoblastic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):608-16.
2006: Yuxiang Zhang; Sanjeev Banerjee; Zhiwei Wang; Hu Xu; Liyue Zhang; Ramzi M Mohammad; Amro Aboukameel; N Volkan Adsay; Mingxin Che; James L Abbruzzese; Adhip N Majumdar; Asfar S Azmi
Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer.
Cancer research 2006;66(2):1025-32.
2005: Ramzi M Mohammad; Shaomeng Wang; Sanjeev Banerjee; Xihan Wu; Jianyong Chen; Asfar S Azmi
Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line.
Pancreas 2005;31(4):317-24.
2005: Mingjun Liu; Yubin Ge; Diane C Cabelof; Amro Aboukameel; Ahmad R Heydari; Ramzi M Mohammad; Larry H Matherly
Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates.
The Journal of biological chemistry 2005;280(7):5588-97.
2005: Ramzi M Mohammad; Shaomeng Wang; Amro Aboukameel; Ben D Chen; Xihan Wu; Jianyong Chen; Ayad Al-Katib
Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma.
Molecular cancer therapeutics 2005;4(1):13-21.
2004: Edi Levi; Ramzi M Mohammad; Udayini Kodali; Dorota J Marciniak; Sudha Reddy; Amro Aboukameel; Asfar S Azmi; Omer Kucuk; Arun K Rishi; Adhip N Majumdar
EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo.
Anticancer research 2004;24(5A):2885-91.
2004: Claire Quiney; Daniel Dauzonne; Catherine Kern; Jean-Dominique Fourneron; Jean-Claude Izard; Ramzi M Mohammad; Jean-Pierre Kolb; Christian Billard
Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells.
Leukemia research 2004;28(8):851-61.
2004: Frances W J Beck; David Eilender; Mahmoud H Dandashi; Fauzia Siddiq; Diane C Snell; Michele A Godmere; Ayad Al-Katib; Ramzi M Mohammad
Factors affecting bryostatin 1-enhanced 2-CdA cytotoxicity in resistant B-cell chronic lymphocytic leukemia.
International journal of molecular medicine 2004;14(1):113-9.
2003: Ramzi M Mohammad; Ayad Al-Katib; Amro Aboukameel; Daniel R Doerge; Asfar S Azmi; Omer Kucuk
Genistein sensitizes diffuse large cell lymphoma to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy.
Molecular cancer therapeutics 2003;2(12):1361-8.
2003: Edith J Mensah-Osman; Ayad Al-Katib; Mahmoud H Dandashi; Ramzi M Mohammad
XK469, a topo IIbeta inhibitor, induces apoptosis in Waldenstrom's macroglobulinemia through multiple pathways.
International journal of oncology 2003;23(6):1637-44.
2003: Edith J Mensah-Osman; Ayad Al-Katib; Ramzi M Mohammad
Preclinical evaluation of 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid as a modulator of etoposide in human Waldenstrom's macroglobulinemia xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5794-7.
2003: Yuxiang Zhang; Marcia I Dawson; Yangmin Ning; Lisa Anne Polin ; Ralph E Parchment; Thomas H Corbett; Anwar N Mohamed; Kai-Chia Feng; Lulu Farhana; Arun K Rishi; Donna Hogge; Mark Leid; Valerie J Peterson; Xiao-kun Zhang; Ramzi M Mohammad; Jin-Song Lu; Cheryl L Willman; Eric VanBuren; Sandra Biggar; Mark Edelstein; David Eilender; Joseph A Fontana
Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog.
Blood 2003;102(10):3743-52.
2003: Arun K Rishi; Liyue Zhang; Madanamohan Boyanapalli; Anil Wali; Ramzi M Mohammad; Yingjie Yu; Joseph A Fontana; James S Hatfield; Marcia I Dawson; Adhip N Majumdar; Uwe Reichert
Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.
The Journal of biological chemistry 2003;278(35):33422-35.
2003: Dorota J Marciniak; Lathika Moragoda; Ramzi M Mohammad; Yingjie Yu; Kiran K Nagothu; Amro Aboukameel; Asfar S Azmi; Volkan Adsay; Arun K Rishi; Adhip N Majumdar
Epidermal growth factor receptor-related protein: a potential therapeutic agent for colorectal cancer.
Gastroenterology 2003;124(5):1337-47.
2003: Ayad Al-Katib; Edith J Mensah-Osman; Amro Aboukameel; Ramzi M Mohammad
The Wayne State University Waldenstrom's Macroglobulinemia preclinical model for Waldenstrom's macroglobulinemia.
Seminars in oncology 2003;30(2):313-7.
2002: Edith J Mensah-Osman; Ayad Al-Katib; Hai-Young Wu; Nadir I Osman; Ramzi M Mohammad
2-[4-(7-chloro-2-quinoxalinyloxyphenoxy]-propionic acid (XK469), an inhibitor of topoisomerase (Topo) IIbeta, up-regulates Topo IIalpha and enhances Topo IIalpha-mediated cytotoxicity.
Molecular cancer therapeutics 2002;1(14):1321-6.
2002: Edith J Mensah-Osman; Ayad Al-Katib; Mahmoud H Dandashi; Ramzi M Mohammad
2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model.
Molecular cancer therapeutics 2002;1(14):1315-20.
2002: Yuxiang Zhang; Marcia I Dawson; Ramzi M Mohammad; Arun K Rishi; Lulu Farhana; Kai-Chia Feng; Mark Leid; Valerie J Peterson; Xiao-kun Zhang; Mark Edelstein; David Eilander; Sandra Biggar; Nathan Wall; Uwe Reichert; Joseph A Fontana
Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog.
Blood 2002;100(8):2917-25.
2002: Ramzi M Mohammad; Amro Aboukameel; Sanaa M Nabha; Dina Ibrahim; Ayad Al-Katib
Rituximab, Cyclophosphamide, Dexamethasone (RCD) regimen induces cure in WSU-WM xenograft model and a partial remission in previously treated Waldenstrom's macroglobulinemia patient.
Journal of drug targeting 2002;10(5):405-10.
2002: Sanaa M Nabha; Ramzi M Mohammad; Mahmoud H Dandashi; Brigitte Coupaye-Gerard; Amro Aboukameel; George R Pettit; Ayad Al-Katib
Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2735-41.
2002: Viviana Roman; Christian Billard; Catherine Kern; helene ferry dumazet; Jean-Claude Izard; Ramzi M Mohammad; Djavad M Mossalayi; Jean-Pierre Kolb
Analysis of resveratrol-induced apoptosis in human B-cell chronic leukaemia.
British journal of haematology 2002;117(4):842-51.
2002: Ramzi M Mohammad; Yousif Abubakr; Maria Dan; Amro Aboukameel; Christine S Chow; Anwar N Mohamed; Nayera Hamdy; Ayad Al-Katib
Bcl-2 antisense oligonucleotides are effective against systemic but not central nervous system disease in severe combined immunodeficient mice bearing human t(14;18) follicular lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1277-83.
2001: Nathan Wall; Ramzi M Mohammad; Ayad Al-Katib
Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(12):641-7.
2001: Ramzi M Mohammad; N Volkan Adsay; Philip A Philip; George R Pettit; Vainutis K Vaitkevicius; Asfar S Azmi
Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model.
Anti-cancer drugs 2001;12(9):735-40.
2001: Kambiz Merati; M said Siadaty; Aleodor Andea; Asfar S Azmi; Edgar Ben-Josef; Ramzi M Mohammad; Philip A Philip; Anthony F Shields; Vainutis K Vaitkevicius; David Grignon; N Volkan Adsay
Expression of inflammatory modulator COX-2 in pancreatic ductal adenocarcinoma and its relationship to pathologic and clinical parameters.
American journal of clinical oncology 2001;24(5):447-52.
2001: Nathan Wall; Frances W J Beck; Ayad Al-Katib; Ramzi M Mohammad
Treatment-induced expression of anti-apoptotic proteins in WSU-CLL, a human chronic lymphocytic leukemia cell line.
Journal of drug targeting 2001;9(5):329-39.
2001: Sanaa M Nabha; Ramzi M Mohammad; Nathan Wall; JA Dutcher; B M Salkini; George R Pettit; Ayad Al-Katib
Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy.
Anti-cancer drugs 2001;12(1):57-63.
2000: Ramzi M Mohammad; Nathan Wall; JA Dutcher; Ayad Al-Katib
The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4950-6.
2000: Jeffrey W Taub; Xi Huang; Yubin Ge; JA Dutcher; Mark L Stout; Ramzi M Mohammad; Yaddanapudi Ravindranath; Larry H Matherly
Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome.
Cancer research 2000;60(22):6421-6.
2000: Z He; Jeffrey L Evelhoch; Ramzi M Mohammad; N Volkan Adsay; George R Pettit; Vainutis K Vaitkevicius; Asfar S Azmi
Magnetic resonance imaging to measure therapeutic response using an orthotopic model of human pancreatic cancer.
Pancreas 2000;21(1):69-76.
2000: Sanaa M Nabha; Nathan Wall; Ramzi M Mohammad; George R Pettit; Ayad Al-Katib
Effects of combretastatin A-4 prodrug against a panel of malignant human B-lymphoid cell lines.
Anti-cancer drugs 2000;11(5):385-92.
2000: I Ahmad; Ayad Al-Katib; Frances W J Beck; Ramzi M Mohammad
Sequential treatment of a resistant chronic lymphocytic leukemia patient with bryostatin 1 followed by 2-chlorodeoxyadenosine: case report.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1328-32.
2000: Frances W J Beck; Ayad Al-Katib; I Ahmad; Nathan Wall; Kan-Zhi Liu; Henry H Mantsch; Ramzi M Mohammad
Bryostatin 1-induced modulation of nucleoside transporters and 2-chlorodeoxyadenosine influx in WSU-CLL cells.
International journal of molecular medicine 2000;5(4):341-7.
2000: Mary Varterasian; Ramzi M Mohammad; M S Shurafa; K Hulburd; Pamela Pemberton; DH Rodriguez; V Spadoni; David Eilender; A Murgo; Nathan Wall; Maria Dan; Ayad Al-Katib
Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):825-8.
2000: Nathan Wall; Ramzi M Mohammad; Kaladhar B Reddy; Ayad Al-Katib
Bryostatin 1 induces ubiquitination and proteasome degradation of Bcl-2 in the human acute lymphoblastic leukemia cell line, Reh.
International journal of molecular medicine 2000;5(2):165-71.
1999: Nathan Wall; Ramzi M Mohammad; Sanaa M Nabha; George R Pettit; Ayad Al-Katib
Modulation of cIAP-1 by novel antitubulin agents when combined with bryostatin 1 results in increased apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh.
Biochemical and biophysical research communications 1999;266(1):76-80.
1999: Amr Aref; Mark Yudelev; Ramzi M Mohammad; R Choudhuri; Colin G Orton; Ayad Al-Katib
Neutron and photon clonogenic survival curves of two chemotherapy resistant human intermediate-grade non-Hodgkin lymphoma cell lines.
International journal of radiation oncology, biology, physics 1999;45(4):999-1003.
1999: Ramzi M Mohammad; Yiwei Li; Anwar N Mohamed; George R Pettit; Volkan Adsay; Vainutis K Vaitkevicius; Ayad Al-Katib; Asfar S Azmi
Clonal preservation of human pancreatic cell line derived from primary pancreatic adenocarcinoma.
Pancreas 1999;19(4):353-61.
1999: Nathan Wall; Ramzi M Mohammad; Ayad Al-Katib
Bax:Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh.
Leukemia research 1999;23(10):881-8.
1999: Kan-Zhi Liu; CP Schultz; JB Johnston; Frances W J Beck; Ayad Al-Katib; Ramzi M Mohammad; Henry H Mantsch
Infrared spectroscopic study of bryostatin 1-induced membrane alterations in a B-CLL cell line.
Leukemia 1999;13(8):1273-80.
1999: Ramzi M Mohammad; C Limvarapuss; Nathan Wall; Nayera Hamdy; Frances W J Beck; George R Pettit; Ayad Al-Katib
A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model.
International journal of oncology 1999;15(2):367-72.
1999: Ramzi M Mohammad; C Limvarapuss; Nayera Hamdy; B S Dutcher; Frances W J Beck; Nathan Wall; Ayad Al-Katib
Treatment of a de novo fludarabine resistant-CLL xenograft model with bryostatin 1 followed by fludarabine.
International journal of oncology 1999;14(5):945-50.
1999: Amr Aref; Ramzi M Mohammad; Mark Yudelev; R Choudhuri; A Strowbridge; Colin G Orton; Ayad Al-Katib
Radiobiological characterization of two human chemotherapy-resistant intermediate grade non-Hodgkin's lymphoma cell lines.
Radiation oncology investigations 1999;7(3):158-62.
1998: Yiwei Li; Mohammad Bhuiyan; Ramzi M Mohammad; Asfar S Azmi
Induction of apoptosis in breast cancer cells by TPA.
Oncogene 1998;17(22):2915-20.
1998: Ramzi M Mohammad; Frances W J Beck; K Katato; Nayera Hamdy; Nathan Wall; Ayad Al-Katib
Potentiation of 2-chlorodeoxyadenosine activity by bryostatin 1 in the resistant chronic lymphocytic leukemia cell line (WSU-CLL): association with increased ratios of dCK/5'-NT and Bax/Bcl-2.
Biological chemistry 1998;379(10):1253-61.
1998: H Wang; Ramzi M Mohammad; J Werdell; Malathy Puthan Veedu Shekhar
p53 and protein kinase C independent induction of growth arrest and apoptosis by bryostatin 1 in a highly metastatic mammary epithelial cell line: In vitro versus in vivo activity.
International journal of molecular medicine 1998;1(6):915-23.
1998: Kan-Zhi Liu; CP Schultz; Ramzi M Mohammad; Ayad Al-Katib; JB Johnston; Henry H Mantsch
Similarities between the sensitivity to 2-chlorodeoxyadenosine of lymphocytes from CLL patients and bryostatin 1-treated WSU-CLL cells: an infrared spectroscopic study.
Cancer letters 1998;127(1-2):185-93.
1998: Ramzi M Mohammad; Mary Varterasian; VP Almatchy; G N Hannoudi; George R Pettit; Ayad Al-Katib
Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1337-43.
1998: Ayad Al-Katib; Mitchell R Smith; W S Kamanda; George R Pettit; M Hamdan; Anwar N Mohamed; B Chelladurai; Ramzi M Mohammad
Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1305-14.
1998: Ramzi M Mohammad; Ayad Al-Katib; George R Pettit; Vainutis K Vaitkevicius; US Joshi; Volkan Adsay; Adhip N Majumdar; Asfar S Azmi
An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: potential application for preclinical studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):887-94.
1998: Ramzi M Mohammad; K Katato; VP Almatchy; Nathan Wall; Kan-Zhi Liu; CP Schultz; Henry H Mantsch; Mary Varterasian; Ayad Al-Katib
Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine: preclinical studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(2):445-53.
1998: Ramzi M Mohammad; George R Pettit; VP Almatchy; Nathan Wall; Mary Varterasian; Ayad Al-Katib
Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma.
Anti-cancer drugs 1998;9(2):149-56.
1998: Mary Varterasian; Ramzi M Mohammad; David Eilender; K Hulburd; DH Rodriguez; Pamela Pemberton; J M Pluda; Maria Dan; George R Pettit; Ben D Chen; Ayad Al-Katib
Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(1):56-62.
1998: Ramzi M Mohammad; Michael C Dugan; Anwar N Mohamed; VP Almatchy; T M Flake; ST Dergham; Anthony F Shields; Ayad Al-Katib; Vainutis K Vaitkevicius; Asfar S Azmi
Establishment of a human pancreatic tumor xenograft model: potential application for preclinical evaluation of novel therapeutic agents.
Pancreas 1998;16(1):19-25.
1997: A König; Gary K Schwartz; Ramzi M Mohammad; Ayad Al-Katib; JL Gabrilove
The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines.
Blood 1997;90(11):4307-12.
1997: Y Li; Ramzi M Mohammad; Ayad Al-Katib; Mary Varterasian; Ben D Chen
Bryostatin 1 (bryo1)-induced monocytic differentiation in THP-1 human leukemia cells is associated with enhanced c-fyn tyrosine kinase and M-CSF receptors.
Leukemia research 1997;21(5):391-7.
1996: A Maki; Ramzi M Mohammad; S Raza; M Saleh; K D Govindaraju; George R Pettit; Ayad Al-Katib
Effect of dolastatin 10 on human non-Hodgkin's lymphoma cell lines.
Anti-cancer drugs 1996;7(3):344-50.
1996: A Maki; Ramzi M Mohammad; M Smith; Ayad Al-Katib
Role of ubiquitin carboxyl terminal hydrolase in the differentiation of human acute lymphoblastic leukemia cell line, Reh.
Differentiation; research in biological diversity 1996;60(1):59-66.
1996: Ramzi M Mohammad; A Maki; George R Pettit; Ayad Al-Katib
Bryostatin 1 induces ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia cells.
Enzyme & protein 1996;49(5-6):262-72.
1996: Ramzi M Mohammad; Anwar N Mohamed; M Y Hamdan; T Vo; Ben D Chen; K Katato; Y A Abubakr; Michael C Dugan; Ayad Al-Katib
Establishment of a human B-CLL xenograft model: utility as a preclinical therapeutic model.
Leukemia 1996;10(1):130-7.
1995: M R Smith; Y Abubakr; Ramzi M Mohammad; T Xie; M Hamdan; Ayad Al-Katib
Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL.
Cancer gene therapy 1995;2(3):207-12.
1995: Ramzi M Mohammad; H Diwakaran; A Maki; M A Emara; George R Pettit; Bruce G Redman; Ayad Al-Katib
Bryostatin 1 induces apoptosis and augments inhibitory effects of vincristine in human diffuse large cell lymphoma.
Leukemia research 1995;19(9):667-73.
1995: A Maki; H Diwakaran; Bruce G Redman; S al-Asfar; George R Pettit; Ramzi M Mohammad; Ayad Al-Katib
The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.
Anti-cancer drugs 1995;6(3):392-7.
1995: Ayad Al-Katib; Ramzi M Mohammad; A Maki; M R Smith
Induced expression of a ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(2):211-7.
1994: Ramzi M Mohammad; A Maki; K Vistisen; Ayad Al-Katib
Protein studies of human non-Hodgkin's B-lymphoma: appraisal by two-dimensional gel electrophoresis.
Electrophoresis 1994;15(12):1566-72.
1994: Ramzi M Mohammad; K Vistisen; Ayad Al-Katib
Protein study of T and B acute lymphoblastic leukemia cell lines.
Electrophoresis 1994;15(8-9):1218-24.
1994: Ramzi M Mohammad; Ayad Al-Katib; George R Pettit; L L Sensenbrenner
Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents.
Cancer research 1994;54(1):165-8.
1994: Ramzi M Mohammad; M Y Hamdan; Ayad Al-Katib
Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma.
Enzyme & protein 1994;48(1):37-44.
1993: Ramzi M Mohammad; Anwar N Mohamed; Mitchell R Smith; N S Jawadi; Ayad Al-Katib
A unique EBV-negative low-grade lymphoma line (WSU-FSCCL) exhibiting both t(14;18) and t(8;11).
Cancer genetics and cytogenetics 1993;70(1):62-7.
1993: Mitchell R Smith; Ayad Al-Katib; Ramzi M Mohammad; Ann L. Silverman; P Szabo; S Khilnani; W Kohler; R Nath; Milton G Mutchnick
Prothymosin alpha gene expression correlates with proliferation, not differentiation, of HL-60 cells.
Blood 1993;82(4):1127-32.
1993: Ayad Al-Katib; Ramzi M Mohammad; K Khan; M E Dan; George R Pettit; L L Sensenbrenner
Bryostatin 1-induced modulation of the acute lymphoblastic leukemia cell line Reh.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(1):33-42.
1993: Ayad Al-Katib; Ramzi M Mohammad; M Hamdan; Anwar N Mohamed; M Dan; Mitchell R Smith
Propagation of Waldenström's macroglobulinemia cells in vitro and in severe combined immune deficient mice: utility as a preclinical drug screening model.
Blood 1993;81(11):3034-42.
1993: Ramzi M Mohammad; Ayad Al-Katib; George R Pettit; L L Sensenbrenner
Differential effects of bryostatin 1 on human non-Hodgkin's B-lymphoma cell lines.
Leukemia research 1993;17(1):1-8.
1993: Ayad Al-Katib; Ramzi M Mohammad; M Dan; M E Hussein; A Akhtar; George R Pettit; L L Sensenbrenner
Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.
Experimental hematology 1993;21(1):61-5.
1992: Ramzi M Mohammad; Anwar N Mohamed; M KuKuruga; Mitchell R Smith; Ayad Al-Katib
A human B-cell lymphoma line with a de novo multidrug resistance phenotype.
Cancer 1992;69(6):1468-74.
1990: Ayad Al-Katib; Ramzi M Mohammad; Anwar N Mohamed; George R Pettit; L L Sensenbrenner
Conversion of high grade lymphoma tumor cell line to intermediate grade with TPA and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis.
Hematological oncology 1990;8(2):81-9.
1990: B Patel; Ramzi M Mohammad; J Blaustein; Ayad Al-Katib
Induced expression of a monocytoid B lymphocyte antigen phenotype on the REH cell line.
American journal of hematology 1990;33(3):153-9.
1989: Anwar N Mohamed; Ramzi M Mohammad; B F Koop; Ayad Al-Katib
Establishment and characterization of a new human Burkitt's lymphoma cell line (WSU-BL).
Cancer 1989;64(5):1041-8.
1988: Anwar N Mohamed; Alexander Nakeff; Ramzi M Mohammad; M KuKuruga; Ayad Al-Katib
Modulation of c-myc oncogene expression by phorbol ester and interferon-gamma: appraisal by flow cytometry.
Oncogene 1988;3(4):429-35.