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Klaus Mohr

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R Schrage; Wk Seemann; Kurt Racké; Clelia Dallanoce; Marco De Amici; Ulrike Holzgrabe; J Klöckner; Evi Kostenis; Klaus Mohr
Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.
Klaus Mohr; Jens Schmitz; Ramona Schrage; Christian Tränkle; Ulrike Holzgrabe
Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
A S Ahmedat; Uwe R Juergens; W K Seemann; Evi Kostenis; Klaus Mohr; M Warnken; Kurt Racké
Pro-fibrotic processes in human lung fibroblasts are driven by an autocrine/paracrine endothelinergic system.

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All Publications

2013: R Schrage; Wk Seemann; Kurt Racké; Clelia Dallanoce; Marco De Amici; Ulrike Holzgrabe; J Klöckner; Evi Kostenis; Klaus Mohr
Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.
British journal of pharmacology 2013;169(2):357-70.
2013: Klaus Mohr; Jens Schmitz; Ramona Schrage; Christian Tränkle; Ulrike Holzgrabe
Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
Angewandte Chemie (International ed. in English) 2013;52(2):508-16.
2013: A S Ahmedat; Uwe R Juergens; W K Seemann; Evi Kostenis; Klaus Mohr; M Warnken; Kurt Racké
Pro-fibrotic processes in human lung fibroblasts are driven by an autocrine/paracrine endothelinergic system.
British journal of pharmacology 2013;168(2):471-87.
2012: Stefanie Blättermann; Andreas Bock; Jürgen Gäb; Angel Gonzalez; Michael Gütschow; Akos Heinemann; Stephanie Hennen; Viktoria Konya; Petra Luschnig; Klaus Mohr; Philipp Aaron Ottersbach; Leonardo Pardo; Lucas Peters; Ralf Schröder; Rahul Tyagi; Trond Ulven; C David Weaver; Evi Kostenis
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.
Nature chemical biology 2012;8(7):631-8.
2012: Andreas Bock; Clelia Dallanoce; Marco De Amici; Carsten Hoffmann; Ulrike Holzgrabe; Anna Kebig; Jessica Klöckner; Evi Kostenis; Carlo Matera; Nicole Merten; Anke Müller; Lucas Peters; Jens Schmitz; Ramona Schrage; Jasmin Schrobang-Ley; Katharina Simon; Christian Tränkle; Julia Bätz; Klaus Mohr
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling.
Nature communications 2012;3():1044.
2011: Klaus Mohr; Evi Kostenis
Signaling pathways: Purinosomes under GPCR control.
Nature chemical biology 2011;7(12):860-1.
2011: Paul W Elsinghorst; Daniela Gündisch; Wolfgang Härtig; Klaus Mohr; Christian Tränkle; Michael Gütschow
A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins.
Current topics in medicinal chemistry 2011;11(22):2731-48.
2011: Ralf Schröder; Wiebke Seemann; Stefanie Blättermann; Christel Drewke; Jesus Gomeza; Manuel Grundmann; Nicole Janssen; Dorina Kaufel; Nicole Merten; Graeme Milligan; Klaus Mohr; Lucas Peters; Johannes Schmidt; Evi Kostenis
Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.
Nature protocols 2011;6(11):1748-60.
2010: Ralf Schröder; Nicole Janssen; Johannes Schmidt; Anna Kebig; Nicole Merten; Stephanie Hennen; Anke Müller; Stefanie Blättermann; Marion Mohr-Andrä; Sabine Zahn; Jörg Wenzel; Nicola J Smith; Jesús Gomeza; Christel Drewke; Graeme Milligan; Klaus Mohr; Evi Kostenis
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.
Nature biotechnology 2010;28(9):943-9.
2010: Marco De Amici; Clelia Dallanoce; Ulrike Holzgrabe; Christian Tränkle; Klaus Mohr
Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities.
Medicinal research reviews 2010;30(3):463-549.
2010: Klaus Mohr; Christian Tränkle; Evi Kostenis; Elisabetta Barocelli; Marco De Amici; Ulrike Holzgrabe
Rational design of dualsteric GPCR ligands: quests and promise.
British journal of pharmacology 2010;159(5):997-1008.
2009: Johannes Antony; Kerstin Kellershohn; Marion Mohr-Andrä; Anna Kebig; Stefanie Prilla; Mathias Muth; Eberhard Heller; Teresa Disingrini; Clelia Dallanoce; Simona Bertoni; Jasmin Schrobang; Christian Tränkle; Evi Kostenis; Arthur Christopoulos; Hans-Dieter Höltje; Elisabetta Barocelli; Marco De Amici; Ulrike Holzgrabe; Klaus Mohr
Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(2):442-50.
2009: Anna Kebig; Evi Kostenis; Klaus Mohr; Marion Mohr-Andrä
An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators.
Journal of receptor and signal transduction research 2009;29(3-4):140-5.
2008: A Kebig; Klaus Mohr
[Cinacalcet - an allosteric enhancer at the Ca2+-receptor].
Deutsche medizinische Wochenschrift (1946) 2008;133(33):1681-3.
2007: Dorothea Jäger; Caroline Schmalenbach; Stefanie Prilla; Jasmin Schrobang; Anna Kebig; Matthias Sennwitz; Eberhard Heller; Christian Tränkle; Ulrike Holzgrabe; Hans-Dieter Höltje; Klaus Mohr
Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation.
The Journal of biological chemistry 2007;282(48):34968-76.
2007: Paul W Elsinghorst; Julia S Cieslik; Klaus Mohr; Christian Tränkle; Michael Gütschow
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.
Journal of medicinal chemistry 2007;50(23):5685-95.
2007: Trond Ulven; Michael J Gallen; Mads C Nielsen; Nicole Merten; Carola Schmidt; Klaus Mohr; Christian Tränkle; Evi Kostenis
Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2.
Bioorganic & medicinal chemistry letters 2007;17(21):5924-7.
2007: Christian Fieth; Anna Kebig; Klaus Mohr
[Angiogenesis inhibitors in cancer therapy. Bevacizumab against colon carcinoma].
Pharmazie in unserer Zeit 2007;36(6):442-5.
2007: Marion Mohr-Andrä; Klaus Mohr
[Angiogenesis inhibitors for vision loss. Ranibizumab for macular degeneration].
Pharmazie in unserer Zeit 2007;36(6):437-40.
2006: Stefanie Prilla; Jasmin Schrobang; John Ellis; Hans-Dieter Höltje; Klaus Mohr
Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity.
Molecular pharmacology 2006;70(1):181-93.
2006: Ulf Sürig; Klaudia Gaal; Evi Kostenis; Christian Tränkle; Klaus Mohr; Ulrike Holzgrabe
Muscarinic allosteric modulators: atypical structure-activity-relationships in bispyridinium-type compounds.
Archiv der Pharmazie 2006;339(4):207-12.
2006: Darius P Zlotos; Christian Tränkle; Aliaa Abdelrahman; Daniela Gündisch; Krzysztof Radacki; Holger Braunschweig; Klaus Mohr
6H,13H-Pyrazino[1,2-a;4,5-a']diindole analogs: probing the pharmacophore for allosteric ligands of muscarinic M2 receptors.
Bioorganic & medicinal chemistry letters 2006;16(6):1481-5.
2006: Teresa Disingrini; Mathias Muth; Clelia Dallanoce; Elisabetta Barocelli; Simona Bertoni; Kerstin Kellershohn; Klaus Mohr; Marco De Amici; Ulrike Holzgrabe
Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors.
Journal of medicinal chemistry 2006;49(1):366-72.
2006: Ulrike Holzgrabe; Marco De Amici; Klaus Mohr
Allosteric modulators and selective agonists of muscarinic receptors.
Journal of molecular neuroscience : MN 2006;30(1-2):165-8.
2006: Maren Grossmüller; Johannes Antony; Christian Tränkle; Ulrike Holzgrabe; Klaus Mohr
Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.
Naunyn-Schmiedeberg's archives of pharmacology 2006;372(4):267-76.
2005: Christian Tränkle; Andreas Dittmann; Uwe Schulz; Oliver Weyand; Stefan Buller; Kirstin Jöhren; Eberhard Heller; Nigel J M Birdsall; Ulrike Holzgrabe; John Ellis; Hans-Dieter Höltje; Klaus Mohr
Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors.
Molecular pharmacology 2005;68(6):1597-610.
2005: Xi-Ping Huang; Stefanie Prilla; Klaus Mohr; John Ellis
Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide.
Molecular pharmacology 2005;68(3):769-78.
2005: Mathias Muth; Matthias Sennwitz; Klaus Mohr; Ulrike Holzgrabe
Muscarinic allosteric enhancers of ligand binding: pivotal pharmacophoric elements in hexamethonio-type agents.
Journal of medicinal chemistry 2005;48(6):2212-7.
2004: Darius P Zlotos; Stefan Buller; Nikolaus Stiefl; Knut Baumann; Klaus Mohr
Probing the pharmacophore for allosteric ligands of muscarinic M2 receptors: SAR and QSAR studies in a series of bisquaternary salts of caracurine V and related ring systems.
Journal of medicinal chemistry 2004;47(14):3561-71.
2004: Marion Mohr; Eberhard Heller; Ameneh Ataie; Klaus Mohr; Ulrike Holzgrabe
Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.
Journal of medicinal chemistry 2004;47(12):3324-7.
2004: Uta Voigtländer; Klaus Mohr
[Muscarinic acetylcholine receptors as target structures for drugs. Old and new mechanisms].
Medizinische Monatsschrift für Pharmazeuten 2004;27(6):184-90; quiz 191-2.
2004: Andreas Dittmann; Klaus Mohr
[H1 antihistamines: pharmacologic basis and action].
Pharmazie in unserer Zeit 2004;33(2):100-5.
2003: Markus Staudt; Christian Tränkle; Klaus Mohr; Ulrike Holzgrabe
Contribution of lateral substituents in symmetrical and non-symmetrical heptane-bisammonio compounds to the allosteric stabilization of N-methylscopolamine binding to muscarinic M2 receptors.
Archiv der Pharmazie 2003;336(8):385-9.
2003: Christian Tränkle; Oliver Weyand; Uta Voigtländer; Anita Mynett; Sebastian Lazareno; Nigel J M Birdsall; Klaus Mohr
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Molecular pharmacology 2003;64(1):180-90.
2003: Uta Voigtländer; Kirstin Jöhren; Marion Mohr; Alexandra Raasch; Christian Tränkle; Stefan Buller; John Ellis; Hans-Dieter Höltje; Klaus Mohr
Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors.
Molecular pharmacology 2003;64(1):21-31.
2003: Darius P Zlotos; Stefan Buller; Ulrike Holzgrabe; Klaus Mohr
Bisquaternary dimers of strychnine and brucine. A new class of potent enhancers of antagonist binding to muscarinic M2 receptors.
Bioorganic & medicinal chemistry 2003;11(12):2627-34.
2003: Ralf Gilsbach; Maren Grossmüller; Vildan Alptüzün; Ercin Erciyas; Christian Tränkle; Ulrike Holzgrabe; Klaus Mohr
Cooperative interactions at M2 muscarinic acetylcholine receptors: structure/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators.
Neurochemical research 2003;28(3-4):667-73.
2003: Mathias Muth; Wiebke Bender; Olaf Scharfenstein; Ulrike Holzgrabe; Edith Balatkova; Christian Tränkle; Klaus Mohr
Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding.
Journal of medicinal chemistry 2003;46(6):1031-40.
2003: Klaus Mohr; Christian Tränkle; Ulrike Holzgrabe
Structure/activity relationships of M2 muscarinic allosteric modulators.
Receptors & channels 2003;9(4):229-40.
2002: Alexandra Raasch; Olaf Scharfenstein; Christian Tränkle; Ulrike Holzgrabe; Klaus Mohr
Elevation of ligand binding to muscarinic M(2) acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators.
Journal of medicinal chemistry 2002;45(17):3809-12.
2002: Katrin Zahn; Niels Eckstein; Christian Tränkle; Wolfgang Sadée; Klaus Mohr
Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist.
The Journal of pharmacology and experimental therapeutics 2002;301(2):720-8.
2002: Stefan Buller; Darius P Zlotos; Klaus Mohr; John Ellis
Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands.
Molecular pharmacology 2002;61(1):160-8.
2001: Christian Tränkle; Evi Kostenis; Klaus Mohr
Muscarinic allosteric modulation: M2/M3 subtype selectivity of gallamine is independent of G-protein coupling specificity.
Naunyn-Schmiedeberg's archives of pharmacology 2001;364(2):172-8.
2001: R Li; Christian Tränkle; Klaus Mohr; U Holzgrabe
Hexamethonium-type allosteric modulators of the muscarinic receptors bearing lateral dibenzazepine moieties.
Archiv der Pharmazie 2001;334(4):121-4.
2000: A Schröter; Christian Tränkle; Klaus Mohr
Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(6):512-9.
2000: Darius P Zlotos; Stefan Buller; Christian Tränkle; Klaus Mohr
Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors.
Bioorganic & medicinal chemistry letters 2000;10(22):2529-32.
2000: H M Botero Cid; Christian Tränkle; Knut Baumann; R Pick; E Mies-Klomfass; Evi Kostenis; Klaus Mohr; Ulrike Holzgrabe
Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.
Journal of medicinal chemistry 2000;43(11):2155-64.
2000: Wiebke Bender; Markus Staudt; Christian Tränkle; Klaus Mohr; Ulrike Holzgrabe
Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors.
Life sciences 2000;66(18):1675-82.
2000: Ulrike Holzgrabe; Wiebke Bender; H M Cid; Markus Staudt; R Pick; C Pfletschinger; E Balatková; Christian Tränkle; Klaus Mohr
Ligands for the common allosteric site of acetylcholine M2-receptors: development and application.
Pharmaceutica acta Helvetiae 2000;74(2-3):149-55.
2000: Martin Pfaffendorf; HD Batink; Christian Tränkle; Klaus Mohr; Pieter A van Zwieten
Probing the selectivity of allosteric modulators of muscarinic receptors at other G-protein-coupled receptors.
Journal of autonomic pharmacology 2000;20(1):55-62.
2000: C Franken; Christian Tränkle; Klaus Mohr
Testing the specificity of allosteric modulators of muscarinic receptors in phylogenetically closely related histamine H1-receptors.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(2):107-12.
1999: Christian Tränkle; Oliver Weyand; A Schröter; Klaus Mohr
Using a radioalloster to test predictions of the cooperativity model for gallamine binding to the allosteric site of muscarinic acetylcholine M(2) receptors.
Molecular pharmacology 1999;56(5):962-5.
1999: Ursula Ohnmacht; Christian Tränkle; Klaus Mohr; Peter Gmeiner
[3H]Pramipexole: a selective radioligand for the high affinity dopamine D2 receptor in bovine striatal membranes.
Die Pharmazie 1999;54(4):294-7.
1999: Christoph Thomas; Ursula Ohnmacht; K Zahn; Klaus Mohr; Peter Gmeiner
Ex-chiral pool synthesis and pharmacological aspects of 3-pyrrolidinylisoxazoles.
Die Pharmazie 1999;54(4):248-50.
1999: T Nassif-Makki; Christian Tränkle; Darius P Zlotos; G Bejeuhr; A Cambareri; C Pfletschinger; Evi Kostenis; Klaus Mohr; Ulrike Holzgrabe
Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements.
Journal of medicinal chemistry 1999;42(5):849-58.
1998: Christian Tränkle; E Mies-Klomfass; M H Cid; Ulrike Holzgrabe; Klaus Mohr
Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.
Molecular pharmacology 1998;54(1):139-45.
1998: U Burgmer; U Schulz; Christian Tränkle; Klaus Mohr
Interaction of Mg2+ with the allosteric site of muscarinic M2 receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(4):363-70.
1998: Christian Tränkle; I Andresen; Günter Lambrecht; Klaus Mohr
M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site.
Molecular pharmacology 1998;53(2):304-12.
1998: Markus Staudt; Christian Tränkle; Klaus Mohr; Ulrike Holzgrabe
Contribution of lateral substituents in heptane-bisammonium derivatives to the allosteric stabilization of antagonist binding to M2-receptors.
Life sciences 1998;62(5):423-9.
1997: Christian Tränkle; Klaus Mohr
Divergent modes of action among cationic allosteric modulators of muscarinic M2 receptors.
Molecular pharmacology 1997;51(4):674-82.
1997: Christian Tränkle; K Elis; M Wiese; Klaus Mohr
Molecular rigidity and potency of bispyridinium type allosteric modulators at muscarinic M2-receptors.
Life sciences 1997;60(22):1995-2003.
1996: Christian Tränkle; E Kostenis; U Burgmer; Klaus Mohr
Search for lead structures to develop new allosteric modulators of muscarinic receptors.
The Journal of pharmacology and experimental therapeutics 1996;279(2):926-33.
1996: E Kostenis; H M Botero Cid; Y Holzgrabe; Klaus Mohr
Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors.
European journal of pharmacology 1996;314(3):385-92.
1996: E Kostenis; Klaus Mohr
Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation.
Trends in pharmacological sciences 1996;17(8):280-3.
1996: U Burgmer; Klaus Mohr
[Simvastatin].
Deutsche medizinische Wochenschrift (1946) 1996;121(23):769-70.
1996: A Maass; Klaus Mohr
Opposite effects of alcuronium on agonist and on antagonist binding to muscarinic receptors.
European journal of pharmacology 1996;305(1-3):231-4.
1995: Klaus Mohr
[Conjugated estrogens].
Deutsche medizinische Wochenschrift (1946) 1995;120(46):1595-6.
1995: Johann Gasteiger; Ulrike Holzgrabe; E Kostenis; Klaus Mohr; U Sürig; M Wagener
Variation of the oxime function of bispyridinium-type allosteric modulators of M2-cholinoceptors.
Die Pharmazie 1995;50(2):99-105.
1995: A Maass; E Kostenis; Klaus Mohr
Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria.
European journal of pharmacology 1995;272(1):103-6.
1995: B Pieper; Christian Tränkle; M Nieger; Klaus Mohr; J Lehmann
[Lactones. 28. EPC-synthesis, structure and pharmacology of "lactonized" and "lactamized" analogues of acetylcholine].
Die Pharmazie 1995;50(1):15-21.
1994: Klaus Mohr; Christian Tränkle
Allosteric effects of the alkane-bis-ammonium compound W84 and of tacrine on [3H]pirenzepine binding at M1-receptors in rat cerebral cortex.
Pharmacology & toxicology 1994;75(6):391-4.
1994: E Kostenis; Klaus Mohr
[Omeprazole].
Deutsche medizinische Wochenschrift (1946) 1994;119(34-35):1173-4.
1994: A Maass; Klaus Mohr
[Allopurinol].
Deutsche medizinische Wochenschrift (1946) 1994;119(30):1045-6.
1994: M H Botero Cid; Ulrike Holzgrabe; E Kostenis; Klaus Mohr; Christian Tränkle
Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors.
Journal of medicinal chemistry 1994;37(10):1439-45.
1994: G Bejeuhr; G Blaschke; Ulrike Holzgrabe; Klaus Mohr; U Sürig; G Terfloth
A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts.
The Journal of pharmacy and pharmacology 1994;46(2):108-12.