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James Moir

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Jonathan S Ward; Jason M Lynam; James W B Moir; Adrian P Mountford; David E Sanin; Ian J S Fairlamb
A therapeutically viable photo-activated manganese-based CO-releasing molecule (photo-CO-RM).
James Edwards; Diana Quinn; Karyn-Anne Rowbottom; Melanie Thomson; Jean L Whittingham; James W B Moir
Neisseria meningitidis and Neisseria gonorrhoeae are differently adapted in the regulation of denitrification: single nucleotide polymorphisms that enable species-specific tuning of the aerobic-anaerobic switch.
Robin J White; James W B Moir; Vitaly L Budarin; James H Clark
A sweet killer: mesoporous polysaccharide confined silver nanoparticles for antibacterial applications.

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All Publications

2012: Jonathan S Ward; Jason M Lynam; James W B Moir; Adrian P Mountford; David E Sanin; Ian J S Fairlamb
A therapeutically viable photo-activated manganese-based CO-releasing molecule (photo-CO-RM).
Dalton transactions (Cambridge, England : 2003) 2012;41(35):10514-7.
2012: James Edwards; Diana Quinn; Karyn-Anne Rowbottom; Melanie Thomson; Jean L Whittingham; James W B Moir
Neisseria meningitidis and Neisseria gonorrhoeae are differently adapted in the regulation of denitrification: single nucleotide polymorphisms that enable species-specific tuning of the aerobic-anaerobic switch.
The Biochemical journal 2012;445(1):69-79.
2011: Robin J White; James W B Moir; Vitaly L Budarin; James H Clark
A sweet killer: mesoporous polysaccharide confined silver nanoparticles for antibacterial applications.
International journal of molecular sciences 2011;12(9):5782-96.
2010: James Edwards; Lindsay J Cole; Jasper B Green; Melanie Thomson; A Jamie Wood; Jean L Whittingham; James W B Moir
Binding to DNA protects Neisseria meningitidis fumarate and nitrate reductase regulator (FNR) from oxygen.
The Journal of biological chemistry 2010;285(2):1105-12.
2010: Jay R Laver; Tânia M Stevanin; Sarah L Messenger; Amy Dehn Lunn; Margaret E Lee; James W B Moir; Robert K Poole; Robert C Read
Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(1):286-95.
2009: Zhenlian Ling; Michel D L Suits; Richard J Bingham; Neil C Bruce; Gideon J Davies; Antony J Fairbanks; James W B Moir; Edward J Taylor
The X-ray crystal structure of an Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase reveals a (beta/alpha)(8) catalytic domain, two ancillary domains and active site residues key for transglycosylation activity.
Journal of molecular biology 2009;389(1):1-9.
2008: Alan D Goddard; James W B Moir; David J Richardson; Stuart J Ferguson
Interdependence of two NarK domains in a fused nitrate/nitrite transporter.
Molecular microbiology 2008;70(3):667-81.
2008: Manu Deeudom; Michael Koomey; James W B Moir
Roles of c-type cytochromes in respiration in Neisseria meningitidis.
Microbiology (Reading, England) 2008;154(Pt 9):2857-64.
2008: Christoph D Heidecke; Zhenlian Ling; Neil C Bruce; James W B Moir; Thomas B Parsons; Antony J Fairbanks
Enhanced glycosylation with mutants of endohexosaminidase A (endo A).
Chembiochem : a European journal of chemical biology 2008;9(13):2045-51.
2008: Karin Heurlier; Melanie Thomson; Naveed Aziz; James W B Moir
The nitric oxide (NO)-sensing repressor NsrR of Neisseria meningitidis has a compact regulon of genes involved in NO synthesis and detoxification.
Journal of bacteriology 2008;190(7):2488-95.
2008: Thomas W D F Rising; Christoph D Heidecke; James W B Moir; Zhenlian Ling; Antony J Fairbanks
Endohexosaminidase-catalysed glycosylation with oxazoline donors: fine tuning of catalytic efficiency and reversibility.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(21):6444-64.
2008: Melanie Thomson; Tania M Stevanin; James W B Moir
Measuring nitric oxide metabolism in the pathogen Neisseria meningitidis.
Methods in enzymology 2008;437():539-60.
2008: Lindsay J Cole; Wilhelmina M Huston; James W B Moir
Delivery of nitric oxide for analysis of the function of cytochrome c'.
Methods in enzymology 2008;436():21-33.
2007: Tânia M Stevanin; Jay R Laver; Robert K Poole; James W B Moir; Robert C Read
Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophages.
Microbes and infection / Institut Pasteur 2007;9(8):981-7.
2007: Jonathan D Rock; Melanie Thomson; Robert C Read; James W B Moir
Regulation of denitrification genes in Neisseria meningitidis by nitric oxide and the repressor NsrR.
Journal of bacteriology 2007;189(3):1138-44.
2007: Wilhelmina M Huston; Harry R Harhangi; Andrew P Leech; Clive S Butler; Mike S.M. Jetten; Huub J M Op den Camp; James W B Moir
Expression and characterisation of a major c-type cytochrome encoded by gene kustc0563 from Kuenenia stuttgartiensis as a recombinant protein in Escherichia coli.
Protein expression and purification 2007;51(1):28-33.
2006: Thomas W D F Rising; Timothy D W Claridge; James W B Moir; Antony J Fairbanks
Endohexosaminidase M: exploring and exploiting enzyme substrate specificity.
Chembiochem : a European journal of chemical biology 2006;7(8):1177-80.
2006: Thomas W D F Rising; Timothy D W Claridge; Nicola Davies; David P Gamblin; James W B Moir; Antony J Fairbanks
Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation.
Carbohydrate research 2006;341(10):1574-96.
2006: Wilhelmina M Huston; Colin R Andrew; Amy E Servid; Alison L McKay; Andrew P Leech; Clive S Butler; James W B Moir
Heterologous overexpression and purification of cytochrome c' from Rhodobacter capsulatus and a mutant (K42E) in the dimerization region. Mutation does not alter oligomerization but impacts the heme iron spin state and nitric oxide binding properties.
Biochemistry 2006;45(14):4388-95.
2006: K Dyet; James W B Moir
Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.
Biochemical Society transactions 2006;34(Pt 1):197-9.
2006: M Deeudom; Jonathan D Rock; James W B Moir
Organization of the respiratory chain of Neisseria meningitidis.
Biochemical Society transactions 2006;34(Pt 1):139-42.
2006: Anne J Tunbridge; Tânia M Stevanin; Margaret Lee; Helen M Marriott; James W B Moir; Robert C Read; David H Dockrell
Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.
Infection and immunity 2006;74(1):729-33.
2005: Jonathan D Rock; M Reda Mahnane; Muna F Anjum; Jonathan G Shaw; Robert C Read; James W B Moir
The pathogen Neisseria meningitidis requires oxygen, but supplements growth by denitrification. Nitrite, nitric oxide and oxygen control respiratory flux at genetic and metabolic levels.
Molecular microbiology 2005;58(3):800-9.
2005: Colin R Andrew; Lenord J Kemper; Tammy L Busche; Arianne M Tiwari; Michael C Kecskes; James M Stafford; Lea C Croft; Shen Lu; Pierre Moanne-Loccoz; Wilhelmina M Huston; James W B Moir; Robert R Eady
Accessibility of the distal heme face, rather than Fe-His bond strength, determines the heme-nitrosyl coordination number of cytochromes c': evidence from spectroscopic studies.
Biochemistry 2005;44(24):8664-72.
2005: Tânia M Stevanin; James W B Moir; Robert C Read
Nitric oxide detoxification systems enhance survival of Neisseria meningitidis in human macrophages and in nasopharyngeal mucosa.
Infection and immunity 2005;73(6):3322-9.
2005: Sue M Turner; James W B Moir; Lesley Griffiths; Tim W Overton; Harry Smith; Jeffrey A Cole
Mutational and biochemical analysis of cytochrome c', a nitric oxide-binding lipoprotein important for adaptation of Neisseria gonorrhoeae to oxygen-limited growth.
The Biochemical journal 2005;388(Pt 2):545-53.
2005: Wilhelmina M Huston; E C Lowe; Clive S Butler; James W B Moir
Purification and characterization of cytochrome c' from Neisseria meningitidis.
Biochemical Society transactions 2005;33(Pt 1):187-9.
2005: Jonathan D Rock; James W B Moir
Microaerobic denitrification in Neisseria meningitidis.
Biochemical Society transactions 2005;33(Pt 1):134-6.
2002: Susannah R Poock; Emily R Leach; James W B Moir; Jeffrey A Cole; David J Richardson
Respiratory detoxification of nitric oxide by the cytochrome c nitrite reductase of Escherichia coli.
The Journal of biological chemistry 2002;277(26):23664-9.
2002: Muna F Anjum; Tânia M Stevanin; Robert C Read; James W B Moir
Nitric oxide metabolism in Neisseria meningitidis.
Journal of bacteriology 2002;184(11):2987-93.
2002: Nicholas J Wood; Tooba Alizadeh; David J Richardson; Stuart J Ferguson; James W B Moir
Two domains of a dual-function NarK protein are required for nitrate uptake, the first step of denitrification in Paracoccus pantotrophus.
Molecular microbiology 2002;44(1):157-70.
2001: Nicholas J Wood; Tooba Alizadeh; S Bennett; J Pearce; S J Ferguson; D J Richardson; James W B Moir
Maximal expression of membrane-bound nitrate reductase in Paracoccus is induced by nitrate via a third FNR-like regulator named NarR.
Journal of bacteriology 2001;183(12):3606-13.
2001: R Cross; D Lloyd; Robert K Poole; James W B Moir
Enzymatic removal of nitric oxide catalyzed by cytochrome c' in Rhodobacter capsulatus.
Journal of bacteriology 2001;183(10):3050-4.
2001: James W B Moir; Nicholas J Wood
Nitrate and nitrite transport in bacteria.
Cellular and molecular life sciences : CMLS 2001;58(2):215-24.
2000: R Cross; Joanne L Aish; S J Paston; Robert K Poole; James W B Moir
Cytochrome c' from Rhodobacter capsulatus confers increased resistance to nitric oxide.
Journal of bacteriology 2000;182(5):1442-7.
1999: Nicholas J Watmough; Gareth Butland; Myles R Cheesman; James W B Moir; David J Richardson; Stephen Spiro
Nitric oxide in bacteria: synthesis and consumption.
Biochimica et biophysica acta 1999;1411(2-3):456-74.
1999: James W B Moir
Cytochrome c' from Paracoccus denitrificans: spectroscopic studies consistent with a role for the protein in nitric oxide metabolism.
Biochimica et biophysica acta 1999;1430(1):65-72.
1999: D J Blyth; J W Aylott; James W B Moir; David J Richardson; David A Russell
Optical biosensing of nitric oxide using the metalloprotein cytochrome c'.
The Analyst 1999;124(2):129-34.
1998: Lisa Crossman; James W B Moir; Stephen Spiro; David J Richardson
Heterotrophic nitrification in Paracoccus denitrificans.
Biochemical Society transactions 1998;26(3):S208.
1998: David J Richardson; J M Wehrfritz; AM Keech; Lisa Crossman; M D Roldan; HJ Sears; Clive S Butler; Ann Reilly; James W B Moir; Ben C Berks; Stuart J Ferguson; Andrew J Thomson; Stephen Spiro
The diversity of redox proteins involved in bacterial heterotrophic nitrification and aerobic denitrification.
Biochemical Society transactions 1998;26(3):401-8.
1997: Myles R Cheesman; Stuart J Ferguson; James W B Moir; David J Richardson; Walter G Zumft; Andrew J Thomson
Two enzymes with a common function but different heme ligands in the forms as isolated. Optical and magnetic properties of the heme groups in the oxidized forms of nitrite reductase, cytochrome cd1, from Pseudomonas stutzeri and Thiosphaera pantotropha.
Biochemistry 1997;36(51):16267-76.
1997: Lisa Crossman; James W B Moir; J J Enticknap; David J Richardson; Stephen Spiro
Heterologous expression of heterotrophic nitrification genes.
Microbiology (Reading, England) 1997;143 ( Pt 12)():3775-83.
1996: James W B Moir; J M Wehrfritz; Stephen Spiro; David J Richardson
The biochemical characterization of a novel non-haem-iron hydroxylamine oxidase from Paracoccus denitrificans GB17.
The Biochemical journal 1996;319 ( Pt 3)():823-7.
1996: James W B Moir; Lisa Crossman; Stephen Spiro; David J Richardson
The purification of ammonia monooxygenase from Paracoccus denitrificans.
FEBS letters 1996;387(1):71-4.
1995: Ben C Berks; Stuart J Ferguson; James W B Moir; David J Richardson
Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions.
Biochimica et biophysica acta 1995;1232(3):97-173.
1995: P A Williams; Vilmos Fülöp; Y C Leung; C Chan; James W B Moir; G Howlett; Stuart J Ferguson; S E Radford; Janos Hajdu
Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c550 and cytochrome cd1 nitrite reductase.
Nature structural biology 1995;2(11):975-82.
1995: Vilmos Fülöp; James W B Moir; Stuart J Ferguson; Janos Hajdu
The anatomy of a bifunctional enzyme: structural basis for reduction of oxygen to water and synthesis of nitric oxide by cytochrome cd1.
Cell 1995;81(3):369-77.
1993: James W B Moir; Stuart J Ferguson
Spontaneous mutation of Thiosphaera pantotropha enabling growth on methanol correlates with synthesis of a 26 kDa c-type cytochrome.
FEMS microbiology letters 1993;113(3):321-6.
1993: Vilmos Fülöp; James W B Moir; Stuart J Ferguson; Janos Hajdu
Crystallization and preliminary crystallographic study of cytochrome cd1 nitrite reductase from Thiosphaera pantotropha.
Journal of molecular biology 1993;232(4):1211-2.
1993: James W B Moir; D Baratta; David J Richardson; Stuart J Ferguson
The purification of a cd1-type nitrite reductase from, and the absence of a copper-type nitrite reductase from, the aerobic denitrifier Thiosphaera pantotropha; the role of pseudoazurin as an electron donor.
European journal of biochemistry / FEBS 1993;212(2):377-85.