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Lyle Moldawer
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49
Lowry, Stephen
33
Copeland, Edward
21
Clare-Salzler, Michael
21
MacKay, Sally
19
Tannahill, Cynthia
18
Oberholzer, Andreas
18
Abouhamze, Amer
18
Fong, Yuman
17
Efron, Philip
17
Oberholzer, Caroline
17
Scumpia, Philip
16
Bahjat, Frances
15
Baker, Henry
14
Seeger, James
13
Coyle, Susette
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All Publications
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2009: Bogner Viktoria; Baker Henry V; Kanz Karl-Georg; Moldawer L L; Mutschler Wolf; Biberthaler Peter
Hemorrhage and subsequent allogenic red blood cell transfusion are associated with characteristic monocyte messenger RNA expression patterns in patients after multiple injury-a genome wide view.
The Journal of trauma 2009;67(4):792-801.
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2009: Efron Philip A; Matsumoto Tadashi; McAuliffe Priscilla F; Scumpia Philip; Ungaro Ricardo; Fujita Shiro; Moldawer Lyle L; Foley David; Hemming Alan W
Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes.
Journal of clinical immunology 2009;29(5):568-81.
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2009: Warren H Shaw; Elson Constance M; Hayden Douglas L; Schoenfeld David A; Cobb J Perren; Maier Ronald V; Moldawer Lyle L; Moore Ernest E; Harbrecht Brian G; Pelak Kimberly; Cuschieri Joseph; Herndon David N; Jeschke Marc G; Finnerty Celeste C; Brownstein Bernard H; Hennessy Laura; Mason Philip H; Tompkins Ronald G;
A genomic score prognostic of outcome in trauma patients.
Molecular medicine (Cambridge, Mass.) 2009;15(7-8):220-7.
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2009: Delano Matthew J; Moldawer Lyle L
Magic bullets and surrogate biomarkers circa 2009.
Critical care medicine 2009;37(5):1796-8.
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2009: Pande Kalyan; Ueda Roanna; Machemer Todd; Sathe Manjiri; Tsai Van; Brin Elena; Delano Matthew J; Van Rooijen Nico; McClanahan Terrill K; Talmadge James E; Moldawer Lyle L; Phillips Joseph H; LaFace Drake M
Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(3):508-15.
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2009: Qian Wei-Jun; Liu Tao; Petyuk Vladislav A; Gritsenko Marina A; Petritis Brianne O; Polpitiya Ashoka D; Kaushal Amit; Xiao Wenzhong; Finnerty Celeste C; Jeschke Marc G; Jaitly Navdeep; Monroe Matthew E; Moore Ronald J; Moldawer Lyle L; Davis Ronald W; Tompkins Ronald G; Herndon David N; Camp David G; Smith Richard D;
Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample.
Journal of proteome research 2009;8(1):290-9.
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2009: Seok Junhee; Xiao Wenzhong; Moldawer Lyle L; Davis Ronald W; Covert Markus W
A dynamic network of transcription in LPS-treated human subjects.
BMC systems biology 2009;3():78.
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2008: Tschoeke S K; Oberholzer C; LaFace D; Hutchins B; Moldawer L L; Oberholzer A
Endogenous IL-10 regulates sepsis-induced thymic apoptosis and improves survival in septic IL-10 null mice.
Scandinavian journal of immunology 2008;68(6):565-71.
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2008: Winfield Robert D; Delano Matthew J; Pande Kalyan; Scumpia Philip O; Laface Drake; Moldawer Lyle L
Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation for an old problem.
JPEN. Journal of parenteral and enteral nutrition 2008;32(6):651-5.
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2008: Wynn James L; Scumpia Philip O; Winfield Robert D; Delano Matthew J; Kelly-Scumpia Kindra; Barker Tolga; Ungaro Ricardo; Levy Ofer; Moldawer Lyle L
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists.
Blood 2008;112(5):1750-8.
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2008: Russom Aman; Sethu Palaniappan; Irimia Daniel; Mindrinos Michael N; Calvano Steve E; Garcia Iris; Finnerty Celeste; Tannahill Cynthia; Abouhamze Amer; Wilhelmy Julie; López M Cecilia; Baker Henry V; Herndon David N; Lowry Stephen F; Maier Ronald V; Davis Ronald W; Moldawer Lyle L; Tompkins Ronald G; Toner Mehmet;
Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.
Clinical chemistry 2008;54(5):891-900.
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2008: Kim Jae-Sung; Nitta Takashi; Mohuczy Dagmara; O'Malley Kerri A; Moldawer Lyle L; Dunn William A; Behrns Kevin E
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes.
Hepatology (Baltimore, Md.) 2008;47(5):1725-36.
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2008: Warner Elizabeth A; Moldawer Lyle L
Using innate immunity to characterize the host response to microbial invasion in severe sepsis.
Future microbiology 2008;3():177-89.
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2008: Tsujimoto Hironori; Ono Satoshi; Efron Philip A; Scumpia Philip O; Moldawer Lyle L; Mochizuki Hidetaka
Role of Toll-like receptors in the development of sepsis.
Shock (Augusta, Ga.) 2008;29(3):315-21.
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2007: Scumpia Philip O; Delano Matthew J; Kelly-Scumpia Kindra M; Weinstein Jason S; Wynn James L; Winfield Robert D; Xia Changqing; Chung Chun Shiang; Ayala Alfred; Atkinson Mark A; Reeves Westley H; Clare-Salzler Michael J; Moldawer Lyle L
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood 2007;110(10):3673-81.
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2007: Kelly-Scumpia Kindra M; Nacionales Dina C; Scumpia Philip O; Weinstein Jason S; Narain Sonali; Moldawer Lyle L; Satoh Minoru; Reeves Westley H
In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen.
Arthritis and rheumatism 2007;56(10):3379-86.
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2007: Moldawer Lyle L
Opening the window on genome-wide expression analyses in sepsis.
American journal of respiratory and critical care medicine 2007;176(7):631-2.
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2007: Escobar Guillermo A; Cheng Aaron M; Moore Ernest E; Johnson Jeffrey L; Tannahill Cynthia; Baker Henry V; Moldawer Lyle L; Banerjee Anirban
Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes.
Annals of surgery 2007;246(1):129-34.
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2007: Delano Matthew J; Scumpia Philip O; Weinstein Jason S; Coco Dominique; Nagaraj Srinivas; Kelly-Scumpia Kindra M; O'Malley Kerri A; Wynn James L; Antonenko Svetlana; Al-Quran Samer Z; Swan Ryan; Chung Chun-Shiang; Atkinson Mark A; Ramphal Reuben; Gabrilovich Dmitry I; Reeves Wesley H; Ayala Alfred; Phillips Joseph; Laface Drake; Heyworth Paul G; Clare-Salzler Michael; Moldawer Lyle L
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.
The Journal of experimental medicine 2007;204(6):1463-74.
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2007: Nelson Peter R; O'Malley Kerri A; Feezor Robert J; Moldawer Lyle L; Seeger James M
Genomic and proteomic determinants of lower extremity revascularization failure: rationale and study design.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2007;45 Suppl A():A82-91.
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2007: Bogner V; Kirchhoff C; Baker H V; Stegmaier J C; Moldawer L L; Mutschler W; Biberthaler P
Gene expression profiles are influenced by ISS, MOF, and clinical outcome in multiple injured patients: a genome-wide comparative analysis.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2007;392(3):255-65.
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2007: Uchida Takefumi; Scumpia Philip O; Murasko Donna M; Seki Shuhji; Woulfe Susan; Clare-Salzler Michael J; Moldawer Lyle L
Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3886-92.
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2007: Opal Steven M; Lim Yow-Pin; Siryaporn Edward; Moldawer Lyle L; Pribble John P; Palardy John E; Souza Sonia
Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis.
Critical care medicine 2007;35(2):387-92.
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2006: Scumpia Philip O; Delano Matthew J; Kelly Kindra M; O'Malley Kerri A; Efron Philip A; McAuliffe Priscilla F; Brusko Todd; Ungaro Ricardo; Barker Tolga; Wynn James L; Atkinson Mark A; Reeves Westley H; Salzler Michael J Clare; Moldawer Lyle L
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7943-9.
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2006: Tsujimoto Hironori; Ono Satoshi; Matsumoto Atsushi; Kawabata Toshinobu; Kinoshita Manabu; Majima Takashi; Hiraki Shuichi; Seki Shuhji; Moldawer Lyle L; Mochizuki Hidetaka
A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells.
Journal of hepatology 2006;45(6):836-43.
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2006: Matsumoto Tadashi; O'Malley Kerri; Efron Philip A; Burger Colette; McAuliffe Priscilla F; Scumpia Philip O; Uchida Takefumi; Tschoeke Sven K; Fujita Shiro; Moldawer Lyle L; Hemming Alan W; Foley David P
Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.
Surgery 2006;140(5):793-802.
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2006: Tsujimoto Hironori; Efron Philip A; Matsumoto Tadashi; Ungaro Ricardo F; Abouhamze Amer; Ono Satoshi; Mochizuki Hidetaka; Moldawer Lyle L
Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA.
Immunology letters 2006;107(2):155-62.
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2006: Laudanski Krzysztof; Miller-Graziano Carol; Xiao Wenzhong; Mindrinos Michael N; Richards Daniel R; De Asit; Moldawer Lyle L; Maier Ronald V; Bankey Paul; Baker Henry V; Brownstein Bernard H; Cobb J Perren; Calvano Steve E; Davis Ronald W; Tompkins Ronald G
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15564-9.
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2006: O'Malley Kerri; Moldawer Lyle L
Interleukin-6: Still crazy after all these years.
Critical care medicine 2006;34(10):2690-1.
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2006: Liu Tao; Qian Wei-Jun; Gritsenko Marina A; Xiao Wenzhong; Moldawer Lyle L; Kaushal Amit; Monroe Matthew E; Varnum Susan M; Moore Ronald J; Purvine Samuel O; Maier Ronald V; Davis Ronald W; Tompkins Ronald G; Camp David G; Smith Richard D;
High dynamic range characterization of the trauma patient plasma proteome.
Molecular & cellular proteomics : MCP 2006;5(10):1899-913.
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2006: Edwards Carl K; Bendele Alison M; Reznikov Leonid I; Fantuzzi Giamila; Chlipala Elizabeth S; Li Li; Moldawer Lyle L; Mountz John D; Li Yi-Yang Yvonne; Dinarello Charles A
Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha.
Arthritis and rheumatism 2006;54(9):2872-85.
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2006: Sethu Palaniappan; Moldawer Lyle L; Mindrinos Michael N; Scumpia Philip O; Tannahill Cynthia L; Wilhelmy Julie; Efron Philip A; Brownstein Bernard H; Tompkins Ronald G; Toner Mehmet
Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.
Analytical chemistry 2006;78(15):5453-61.
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2006: Moldawer Lyle L
What's new in Shock, June 2006?
Shock (Augusta, Ga.) 2006;25(6):555-6.
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2006: Mathur Amit; Baz Maher; Staples E Denmark; Bonnell Mark; Speckman Jerry M; Hess Phillip J; Klodell Charles T; Knauf Daniel G; Moldawer Lyle L; Beaver Thomas M
Cytokine profile after lung transplantation: correlation with allograft injury.
The Annals of thoracic surgery 2006;81(5):1844-9; discussion 1849-50.
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2006: Tsujimoto Hironori; Ono Satoshi; Majima Takashi; Efron Philip A; Kinoshita Manabu; Hiraide Hoshio; Moldawer Lyle L; Mochizuki Hidetaka
Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress.
Clinical immunology (Orlando, Fla.) 2006;119(2):180-7.
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2006: Oberholzer Caroline; Tschoeke Sven K; Moldawer Lyle L; Oberholzer Andreas
Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice.
Journal of molecular medicine (Berlin, Germany) 2006;84(5):389-95.
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2006: Tschoeke Sven K; Oberholzer Andreas; Moldawer Lyle L
Interleukin-18: a novel prognostic cytokine in bacteria-induced sepsis.
Critical care medicine 2006;34(4):1225-33.
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2006: Delano Matthew J; Moldawer Lyle L
The origins of cachexia in acute and chronic inflammatory diseases.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2006;21(1):68-81.
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2006: McAuliffe P F; Murday M E; Efron P A; Scumpia P O; Ungaro R; Abouhamze Amer; Tannahill C L; Hutchins B; LaFace D; Moldawer L L
Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure.
Gene therapy 2006;13(3):276-82.
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2005: Marshall John C; Deitch Edwin; Moldawer Lyle L; Opal Steven; Redl Heinz; van der Poll Tom
Preclinical models of shock and sepsis: what can they tell us?
Shock (Augusta, Ga.) 2005;24 Suppl 1():1-6.
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2005: Scumpia Philip O; Moldawer Lyle L
Biology of interleukin-10 and its regulatory roles in sepsis syndromes.
Critical care medicine 2005;33(12 Suppl):S468-71.
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2005: McAuliffe Priscilla F; Efron Philip A; Scumpia Philip O; Uchida Takefumi; Mutschlecner Sarah C; Rout W Robert; Moldawer Lyle L; Cendan Juan C
Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery.
Obesity surgery 2005;15(10):1424-31.
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2005: Schreiber Jeffrey; Efron Philip A; Park Julie E; Moldawer Lyle L; Barbul Adrian
Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing.
Surgery 2005;138(5):940-6.
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2005: Feezor Robert J; Cheng Angela; Paddock Heather N; Baker Henry V; Moldawer Lyle L
Functional genomics and gene expression profiling in sepsis: beyond class prediction.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41 Suppl 7():S427-35.
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2005: De Asit K; Miller-Graziano Carol L; Calvano Steve E; Laudanski Krzysztof; Lowry Stephen F; Moldawer Lyle L; Remick Daniel G; Rajicic Natasa; Schoenfeld David; Tompkins Ronald G
Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6155-62.
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2005: Calvano Steve E; Xiao Wenzhong; Richards Daniel R; Felciano Ramon M; Baker Henry V; Cho Raymond J; Chen Richard O; Brownstein Bernard H; Cobb J Perren; Tschoeke S Kevin; Miller-Graziano Carol; Moldawer Lyle L; Mindrinos Michael N; Davis Ronald W; Tompkins Ronald G; Lowry Stephen F;
A network-based analysis of systemic inflammation in humans.
Nature 2005;437(7061):1032-7.
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2005: Tsujimoto Hironori; Uchida Takefumi; Efron Philip A; Scumpia Philip O; Verma Amrisha; Matsumoto Tadashi; Tschoeke Sven K; Ungaro Ricardo F; Ono Satoshi; Seki Shuhji; Clare-Salzler Michael J; Baker Henry V; Mochizuki Hidetaka; Ramphal Reuben; Moldawer Lyle L
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.
Journal of leukocyte biology 2005;78(4):888-97.
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2005: Scumpia Philip O; McAuliffe Priscilla F; O'Malley Kerri A; Ungaro Ricardo; Uchida Takefumi; Matsumoto Tadashi; Remick Daniel G; Clare-Salzler Michael J; Moldawer Lyle L; Efron Philip A
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3282-6.
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2005: Biberthaler Peter; Bogner Viktoria; Baker Henry V; López M Cecilia; Neth Peter; Kanz Karl-Georg; Mutschler Wolf; Jochum Marianne; Moldawer Lyle L
Genome-wide monocytic mRNA expression in polytrauma patients for identification of clinical outcome.
Shock (Augusta, Ga.) 2005;24(1):11-9.
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2005: Litherland S A; Xie T X; Grebe K M; Davoodi-Semiromi A; Elf J; Belkin N S; Moldawer L L; Clare-Salzler M J
Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages.
Journal of autoimmunity 2005;24(4):297-310.
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2005: Oberholzer Andreas; Oberholzer Caroline; Efron Philip A; Scumpia Philip O; Uchida Takefumi; Bahjat Keith; Ungaro Ricardo; Tannahill Cynthia L; Murday Michelle; Bahjat Frances R; Tsai Van; Hutchins Beth; Moldawer Lyle L; Laface Drake; Clare-Salzler Michael J
Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.
Shock (Augusta, Ga.) 2005;23(6):507-15.
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2005: Oberholzer Andreas; Souza Sonia M; Tschoeke Sven K; Oberholzer Caroline; Abouhamze Amer; Pribble John P; Moldawer Lyle L
Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis.
Shock (Augusta, Ga.) 2005;23(6):488-93.
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2005: Qian Wei-Jun; Monroe Matthew E; Liu Tao; Jacobs Jon M; Anderson Gordon A; Shen Yufeng; Moore Ronald J; Anderson David J; Zhang Rui; Calvano Steve E; Lowry Stephen F; Xiao Wenzhong; Moldawer Lyle L; Davis Ronald W; Tompkins Ronald G; Camp David G; Smith Richard D;
Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.
Molecular & cellular proteomics : MCP 2005;4(5):700-9.
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2005: Oberholzer C; Tschoeke S K; Bahjat K; LaFace D; Hutchins B; Clare-Salzler M J; Moldawer L L; Oberholzer A
In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases.
Scandinavian journal of immunology 2005;61(4):309-15.
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2005: Lainée Pierre; Efron Philip; Tschoeke Sven K; Elies Laetitia; De Winter Hilde; Lorré Katrien; Moldawer Lyle L
Delayed neutralization of interferon-gamma prevents lethality in primate Gram-negative bacteremic shock.
Critical care medicine 2005;33(4):797-805.
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2005: Qian Wei-Jun; Jacobs Jon M; Camp David G; Monroe Matthew E; Moore Ronald J; Gritsenko Marina A; Calvano Steve E; Lowry Stephen F; Xiao Wenzhong; Moldawer Lyle L; Davis Ronald W; Tompkins Ronald G; Smith Richard D
Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry.
Proteomics 2005;5(2):572-84.
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2005: Tschoeke Sven K; Moldawer Lyle L
Human leukocyte antigen expression in sepsis: what have we learned?
Critical care medicine 2005;33(1):236-7.
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2005: Tsujimoto Hironori; Ono Satoshi; Majima Takashi; Kawarabayashi Nobuaki; Takayama Eiji; Kinoshita Manabu; Seki Shuhji; Hiraide Hoshio; Moldawer Lyle L; Mochizuki Hidetaka
Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.
Shock (Augusta, Ga.) 2005;23(1):39-44.
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2005: Matsumoto Tadashi; Efron Philip A; Tsujimoto Hironori; Tschoeke Sven K; Ungaro Ricardo; Fujita Shiro; Foley David P; Hemming Alan; Moldawer Lyle L
Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia.
Laboratory investigation; a journal of technical methods and pathology 2005;85(1):90-8.
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2005: Chao Ta-Hsiang; Lam Thanh; Vong Binh G; Través Paqui G; Hortelano Sonsoles; Chowdhury Chinmay; Bahjat F Rena; Lloyd G Kenneth; Moldawer Lyle L; Boscá Lisardo; Palladino Michael A; Theodorakis Emmanuel A
A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.
Chembiochem : a European journal of chemical biology 2005;6(1):133-44.
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2005: Efron Philip A; Tsujimoto Hironori; Bahjat Frances R; Ungaro Ricardo; Debernardis Justin; Tannahill Cynthia; Baker Henry V; Edwards Carl K; Moldawer Lyle L
Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-alpha.
Journal of endotoxin research 2005;11(3):145-60.
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2004: Feezor Robert J; Baker Henry V; Mindrinos Michael; Hayden Doug; Tannahill Cynthia L; Brownstein Bernard H; Fay Adrian; MacMillan Sandra; Laramie Jason; Xiao Wenzhong; Moldawer Lyle L; Cobb J Perren; Laudanski Krzysztof; Miller-Graziano Carol L; Maier Ronald V; Schoenfeld David; Davis Ronald W; Tompkins Ronald G;
Whole blood and leukocyte RNA isolation for gene expression analyses.
Physiological genomics 2004;19(3):247-54.
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2004: Sethu Palaniappan; Anahtar Melis; Moldawer Lyle L; Tompkins Ronald G; Toner Mehmet
Continuous flow microfluidic device for rapid erythrocyte lysis.
Analytical chemistry 2004;76(21):6247-53.
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2004: Oldenburg H S A; Siroen M P C; Boelens P G; Sluijter B J R; Pruitt J H; Naseri A H; Rauwerda J A; Meijer S; Cuesta M A; van Leeuwen P A M; Moldawer L L
Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2004;36(5):266-73.
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2004: Efron Philip A; Martins Antonio; Minnich Douglas; Tinsley Kevin; Ungaro Ricardo; Bahjat Frances R; Hotchkiss Richard; Clare-Salzler Michael; Moldawer Lyle L
Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3035-43.
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2004: Minnich Douglas J; Moldawer Lyle L
Anti-cytokine and anti-inflammatory therapies for the treatment of severe sepsis: progress and pitfalls.
The Proceedings of the Nutrition Society 2004;63(3):437-41.
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2004: Camp E Ramsay; Li Jing; Minnich Douglas J; Brank Adam; Moldawer Lyle L; MacKay Sally L D; Hochwald Steven N
Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer.
Journal of the American College of Surgeons 2004;199(2):249-58.
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2004: Voboril Rene; Hochwald Steven N; Li Jing; Brank Adam; Weberova Jana; Wessels Frank; Moldawer Lyle L; Camp E Ramsay; MacKay Sally L D
Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer.
The Journal of surgical research 2004;120(2):178-88.
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2004: Efron Philip A; Tinsley Kevin; Minnich Douglas J; Monterroso Victor; Wagner J; Lainée Pierre; Lorré Katrien; Swanson Paul E; Hotchkiss Richard; Moldawer Lyle L
Increased lymphoid tissue apoptosis in baboons with bacteremic shock.
Shock (Augusta, Ga.) 2004;21(6):566-71.
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2004: Feezor Robert J; Baker Henry V; Xiao Wenzhong; Lee W Anthony; Huber Thomas S; Mindrinos Michael; Kim Raymond A; Ruiz-Taylor Laurence; Moldawer Lyle L; Davis Ronald W; Seeger James M
Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7103-9.
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2004: Reinhart Konrad; Glück Thomas; Ligtenberg Jack; Tschaikowsky Klaus; Bruining Albert; Bakker Jan; Opal Steven; Moldawer Lyle L; Axtelle Tim; Turner Terence; Souza Sonia; Pribble John
CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14).
Critical care medicine 2004;32(5):1100-8.
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2004: Litherland S A; Xie T X; Grebe K M; Li Y; Moldawer L L; Clare-Salzler M J
IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes.
Journal of autoimmunity 2004;22(3):227-33.
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2004: Schottelius Arndt J G; Moldawer Lyle L; Dinarello Charles A; Asadullah Khusru; Sterry Wolfram; Edwards Carl K
Biology of tumor necrosis factor-alpha- implications for psoriasis.
Experimental dermatology 2004;13(4):193-222.
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2004: Efron Philip A; Moldawer Lyle L
Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response.
The Journal of burn care & rehabilitation 2004;25(2):149-60.
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2004: Blenman Kim R M; Bahjat Frances R; Moldawer Lyle L; Morel Laurence
Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse.
Clinical immunology (Orlando, Fla.) 2004;110(2):124-33.
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2004: Feezor Robert J; Paddock Heather N; Baker Henry V; Varela Juan C; Barreda Joyce; Moldawer Lyle L; Schultz Gregory S; Mozingo David W
Temporal patterns of gene expression in murine cutaneous burn wound healing.
Physiological genomics 2004;16(3):341-8.
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2004: Oberholzer Caroline; Oberholzer Andreas; Tschoeke Sven K; Minter Rebecca M; Bahjat Frances R; LaFace Drake; Hutchins Beth; Moldawer Lyle L
Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression.
Journal of endotoxin research 2004;10(6):393-401.
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2003: Paddock Heather N; Schultz Gregory S; Baker Henry V; Varela Juan Carlos; Beierle Elizabeth A; Moldawer Lyle L; Mozingo David W
Analysis of gene expression patterns in human postburn hypertrophic scars.
The Journal of burn care & rehabilitation 2003;24(6):371-7.
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2003: Efron Philip; Moldawer Lyle L
Sepsis and the dendritic cell.
Shock (Augusta, Ga.) 2003;20(5):386-401.
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2003: Feezor Robert J; Oberholzer Caroline; Baker Henry V; Novick Daniela; Rubinstein Menachem; Moldawer Lyle L; Pribble John; Souza Sonia; Dinarello Charles A; Ertel Wolfgang; Oberholzer Andreas
Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria.
Infection and immunity 2003;71(10):5803-13.
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2003: Lam Thanh; Ling Taotao; Chowdhury Chinmay; Chao Ta-Hsiang; Bahjat F R; Lloyd G K; Moldawer Lyle L; Palladino Michael A; Theodorakis Emmanuel A
Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents.
Bioorganic & medicinal chemistry letters 2003;13(19):3217-21.
-
2003: Palladino Michael A; Bahjat Frances Rena; Theodorakis Emmanuel A; Moldawer Lyle L
Anti-TNF-alpha therapies: the next generation.
Nature reviews. Drug discovery 2003;2(9):736-46.
-
2003: Efron Philip A; Moldawer Lyle L
Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned.
Critical care medicine 2003;31(8):2241-2.
-
2003: Sarcia Paul J; Scumpia Philip O; Moldawer Lyle L; DeMarco Vincent G; Skimming Jeffrey W
Hypothermia induces interleukin-10 and attenuates injury in the lungs of endotoxemic rats.
Shock (Augusta, Ga.) 2003;20(1):41-5.
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2003: Welborn M Burress; Moldawer Lyle L; Seeger James M; Minter Rebecca M; Huber Thomas S
Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion.
Shock (Augusta, Ga.) 2003;20(1):35-40.
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2003: Li Jianhua; Kokkola Riikka; Tabibzadeh Siamak; Yang Runkuan; Ochani Mahendar; Qiang Xiaoling; Harris Helena E; Czura Christopher J; Wang Haichao; Ulloa Luis; Wang Hong; Warren H Shaw; Moldawer Lyle L; Fink Mitchell P; Andersson Ulf; Tracey Kevin J; Yang Huan
Structural basis for the proinflammatory cytokine activity of high mobility group box 1.
Molecular medicine (Cambridge, Mass.) 2003;9(1-2):37-45.
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2003: Hochwald Steven N; Lind D Scott; Malaty John; Copeland Edward M; Moldawer Lyle L; MacKay Sally L D
Antineoplastic therapy in colorectal cancer through proteasome inhibition.
The American surgeon 2003;69(1):15-23.
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2003: Feezor Robert J; Moldawer Lyle L
Genetic polymorphisms, functional genomics and the host inflammatory response to injury and inflammation.
Nestlé Nutrition workshop series. Clinical & performance programme 2003;8():15-32; discussion 32-7.
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2002: Schell Scott R; Wessels Frank J; Abouhamze Amer; Moldawer Lyle L; Copeland Edward M
Pro- and antiinflammatory cytokine production after radiofrequency ablation of unresectable hepatic tumors.
Journal of the American College of Surgeons 2002;195(6):774-81.
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2002: Hoefer Imo E; van Royen Niels; Rectenwald John E; Bray Elizabeth J; Abouhamze Zaher; Moldawer Lyle L; Voskuil Michiel; Piek Jan J; Buschmann Ivo R; Ozaki C Keith
Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis.
Circulation 2002;105(14):1639-41.
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2002: Oberholzer Andreas; Oberholzer Caroline; Bahjat Keith S; Ungaro Ricardo; Tannahill Cynthia L; Murday Michelle; Bahjat Frances R; Abouhamze Zaher; Tsai Van; LaFace Drake; Hutchins Beth; Moldawer Lyle L; Clare-Salzler Michael J
Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3412-8.
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2002: Barth Eberhard; Fischer Guenther; Schneider Elisabeth Marion; Moldawer Lyle L; Georgieff Michael; Weiss Manfred
Peaks of endogenous G-CSF serum concentrations are followed by an increase in respiratory burst activity of granulocytes in patients with septic shock.
Cytokine 2002;17(5):275-84.
-
2002: Rectenwald John E; Minter Rebecca M; Rosenberg Jason J; Gaines Gregory C; Lee Sean; Moldawer Lyle L
Bioglass attenuates a proinflammatory response in mouse peritoneal endotoxicosis.
Shock (Augusta, Ga.) 2002;17(2):135-8.
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2002: Rectenwald John E; Minter Rebecca M; Moldawer Lyle L; Abouhamze Zaher; La Face Drake; Hutchins Elizabeth; Huber Thomas S; Seeger James M; Ozaki C Keith
Interleukin-10 fails to modulate low shear stress-induced neointimal hyperplasia.
The Journal of surgical research 2002;102(2):110-8.
-
2002: Oberholzer Andreas; Oberholzer Caroline; Moldawer Lyle L
Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug.
Critical care medicine 2002;30(1 Suppl):S58-63.
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2001: Rosenberg J J; Martin S W; Seely J E; Kinstler O; Gaines G C; Fukuzuka K; Rose J; Kohno T; Boyle W J; Nelson A; Kieft G L; Marshall W S; Feige U; Gasser J; St Clair J; Frazier J; Abouhamze A; Moldawer L L; Edwards C K
Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(5):2213-23.
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2001: Oberholzer C; Oberholzer A; Bahjat F R; Minter R M; Tannahill C L; Abouhamze A; LaFace D; Hutchins B; Clare-Salzler M J; Moldawer L L
Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11503-8.
-
2001: Oberholzer A; Oberholzer C; Moldawer L L
Sepsis syndromes: understanding the role of innate and acquired immunity.
Shock (Augusta, Ga.) 2001;16(2):83-96.
-
2001: Lind D S; Hochwald S N; Malaty J; Rekkas S; Hebig P; Mishra G; Moldawer L L; Copeland E M; Mackay S
Nuclear factor-kappa B is upregulated in colorectal cancer.
Surgery 2001;130(2):363-9.
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2001: Minter R M; Ferry M A; Murday M E; Tannahill C L; Bahjat F R; Oberholzer C; Oberholzer A; LaFace D; Hutchins B; Wen S; Shinoda J; Copeland E M; Moldawer L L
Adenoviral delivery of human and viral IL-10 in murine sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):1053-9.
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2001: Dhillon H; Kalra S P; Prima V; Zolotukhin S; Scarpace P J; Moldawer L L; Muzyczka N; Kalra P S
Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study.
Regulatory peptides 2001;99(2-3):69-77.
-
2001: Oberholzer C; Oberholzer A; Clare-Salzler M; Moldawer L L
Apoptosis in sepsis: a new target for therapeutic exploration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):879-92.
-
2001: Oberholzer A; Oberholzer C; Minter R M; Moldawer L L
Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target?
Immunology letters 2001;75(3):221-4.
-
2001: Minter R M; Ferry M A; Rectenwald J E; Bahjat F R; Oberholzer A; Oberholzer C; La Face D; Tsai V; Ahmed C M; Hutchins B; Copeland E M; Ginsberg H S; Moldawer L L
Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):277-82.
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2001: Oberholzer A; Oberholzer C; Bahjat F R; Edwards C K; Moldawer L L
Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Journal of endotoxin research 2001;7(5):375-80.
-
2000: Bahjat F R; Dharnidharka V R; Fukuzuka K; Morel L; Crawford J M; Clare-Salzler M J; Moldawer L L
Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6559-67.
-
2000: Lee R H; Efron D T; Tantry U; Stuelten C; Moldawer L L; Abouhamze A; Barbul A
Inhibition of tumor necrosis factor-alpha attenuates wound breaking strength in rats.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2000;8(6):547-53.
-
2000: Fukuzuka K; Edwards C K; Clare-Salzer M; Copeland E M; Moldawer L L; Mozingo D W
Glucocorticoid and Fas ligand induced mucosal lymphocyte apoptosis after burn injury.
The Journal of trauma 2000;49(4):710-6.
-
2000: Whittaker D S; Bahjat K S; Moldawer L L; Clare-Salzler M J
Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4298-304.
-
2000: Rectenwald J E; Moldawer L L; Huber T S; Seeger J M; Ozaki C K
Direct evidence for cytokine involvement in neointimal hyperplasia.
Circulation 2000;102(14):1697-702.
-
2000: Welborn M B; Oldenburg H S; Hess P J; Huber T S; Martin T D; Rauwerda J A; Wesdorp R I; Espat N J; Copeland E M; Moldawer L L; Seeger J M
The relationship between visceral ischemia, proinflammatory cytokines, and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair.
Critical care medicine 2000;28(9):3191-7.
-
2000: Pu S; Dhillon H; Moldawer L L; Kalra P S; Kalra S P
Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor.
Journal of neuroendocrinology 2000;12(9):827-32.
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2000: Dhillon H; Ge Y; Minter R M; Prima V; Moldawer L L; Muzyczka N; Zolotukhin S; Kalra P S; Kalra S P
Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change.
Regulatory peptides 2000;92(1-3):97-105.
-
2000: Norman J; Denham W; Denham D; Yang J; Carter G; Abouhamze A; Tannahill C L; MacKay S L; Moldawer L L
Liposome-mediated, nonviral gene transfer induces a systemic inflammatory response which can exacerbate pre-existing inflammation.
Gene therapy 2000;7(16):1425-30.
-
2000: Back M R; Sarac T P; Moldawer L L; Welborn M B; Seeger J M; Huber T S
Laparotomy prevents lethal endotoxemia in a murine sequential insult model by an IL-10-dependent mechanism.
Shock (Augusta, Ga.) 2000;14(2):157-62.
-
2000: Oldenburg H S; Burress Welborn M; Pruitt J H; Boelens P G; Seeger J M; Martin T D; Wesdorp R I; Rauwerda J A; van Leeuwen P A; Moldawer L L
Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2000;20(2):169-72.
-
2000: Huber T S; Gaines G C; Welborn M B; Rosenberg J J; Seeger J M; Moldawer L L
Anticytokine therapies for acute inflammation and the systemic inflammatory response syndrome: IL-10 and ischemia/reperfusion injury as a new paradigm.
Shock (Augusta, Ga.) 2000;13(6):425-34.
-
2000: Nowak M; Gaines G C; Rosenberg J; Minter R; Bahjat F R; Rectenwald J; MacKay S L; Edwards C K; Moldawer L L
LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(5):R1202-9.
-
2000: Josephs M D; Bahjat F R; Fukuzuka K; Ksontini R; Solorzano C C; Edwards C K; Tannahill C L; MacKay S L; Copeland E M; Moldawer L L
Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(5):R1196-201.
-
2000: Schiffenbauer J; Streit W J; Butfiloski E; LaBow M; Edwards C; Moldawer L L
The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor.
Clinical immunology (Orlando, Fla.) 2000;95(2):117-23.
-
2000: Oberholzer A; Oberholzer C; Moldawer L L
Cytokine signaling--regulation of the immune response in normal and critically ill states.
Critical care medicine 2000;28(4 Suppl):N3-12.
-
2000: Fukuzuka K; Edwards C K; Clare-Salzler M; Copeland E M; Moldawer L L; Mozingo D W
Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(4):R1005-18.
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2000: Josephs M D; Solorzano C C; Taylor M; Rosenberg J J; Topping D; Abouhamze A; Mackay S L; Hirsch E; Hirsh D; Labow M; Moldawer L L
Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(4):R824-30.
-
2000: Minter R M; Rectenwald J E; Fukuzuka K; Tannahill C L; La Face D; Tsai V; Ahmed I; Hutchins E; Moyer R; Copeland E M; Moldawer L L
TNF-alpha receptor signaling and IL-10 gene therapy regulate the innate and humoral immune responses to recombinant adenovirus in the lung.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):443-51.
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1999: Josephs M D; Cheng G; Ksontini R; Moldawer L L; Hocking M P
Products of cyclooxygenase-2 catalysis regulate postoperative bowel motility.
The Journal of surgical research 1999;86(1):50-4.
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1999: Tannahill C L; Fukuzuka K; Marum T; Abouhamze Z; MacKay S L; Copeland E M; Moldawer L L
Discordant tumor necrosis factor-alpha superfamily gene expression in bacterial peritonitis and endotoxemic shock.
Surgery 1999;126(2):349-57.
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1999: Litherland S A; Xie X T; Hutson A D; Wasserfall C; Whittaker D S; She J X; Hofig A; Dennis M A; Fuller K; Cook R; Schatz D; Moldawer L L; Clare-Salzler M J
Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1999;104(4):515-23.
-
1999: Moldawer L L; Edwards P D; Josephs M; Minter R M; Copeland E M; MacKay S L
Application of gene therapy to acute inflammatory diseases.
Shock (Augusta, Ga.) 1999;12(2):83-101.
-
1999: MacKay S L; Tannahill C L; Auffenberg T; Ksontini R; Copeland E M; Moldawer L L
Characterization in vitro and in vivo of hammerhead ribozymes directed against murine tumor necrosis factoralpha.
Biochemical and biophysical research communications 1999;260(2):390-7.
-
1999: Fukuzuka K; Rosenberg J J; Gaines G C; Edwards C K; Clare-Salzler M; MacKay S L; Moldawer L L; Copeland E M; Mozingo D W
Caspase-3-dependent organ apoptosis early after burn injury.
Annals of surgery 1999;229(6):851-8; discussion 858-9.
-
1999: Gaines G C; Welborn M B; Moldawer L L; Huber T S; Harward T R; Seeger J M
Attenuation of skeletal muscle ischemia/reperfusion injury by inhibition of tumor necrosis factor.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 1999;29(2):370-6.
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1998: Hawkins D L; MacKay R J; MacKay S L; Moldawer L L
Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages.
Veterinary immunology and immunopathology 1998;66(1):1-10.
-
1998: Xu B; Kalra P S; Moldawer L L; Kalra S P
Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor.
Regulatory peptides 1998;75-76():391-5.
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1998: Witte M B; Thornton F J; Kiyama T; Efron D T; Schulz G S; Moldawer L L; Barbul A
Metalloproteinase inhibitors and wound healing: a novel enhancer of wound strength.
Surgery 1998;124(2):464-70.
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1998: Denham W; Denham D; Yang J; Carter G; MacKay S; Moldawer L L; Carey L C; Norman J
Transient human gene therapy: a novel cytokine regulatory strategy for experimental pancreatitis.
Annals of surgery 1998;227(6):812-20.
-
1998: MacKay S L; Auffenberg T; Tannahill C L; Ksontini R; Josephs M D; Nowak M; Moldawer L L; Copeland E M
Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype.
Annals of surgery 1998;227(6):781-9.
-
1998: Kaibara A; Espat N J; Auffenberg T; Abouhamze A S; Martin D; Kalra S; Moldawer L L
Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis.
Cytokine 1998;10(6):452-6.
-
1998: Kaibara A; Moshyedi A; Auffenberg T; Abouhamze A; Copeland E M; Kalra S; Moldawer L L
Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting.
The American journal of physiology 1998;274(6 Pt 2):R1518-25.
-
1998: Thornton F J; Schäffer M R; Witte M B; Moldawer L L; MacKay S L; Abouhamze A; Tannahill C L; Barbul A
Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds.
Biochemical and biophysical research communications 1998;246(3):654-9.
-
1998: Ksontini R; MacKay S L; Moldawer L L
Revisiting the role of tumor necrosis factor alpha and the response to surgical injury and inflammation.
Archives of surgery (Chicago, Ill. : 1960) 1998;133(5):558-67.
-
1998: Ksontini R; Colagiovanni D B; Josephs M D; Edwards C K; Tannahill C L; Solorzano C C; Norman J; Denham W; Clare-Salzler M; MacKay S L; Moldawer L L
Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):4082-9.
-
1998: Moshyedi A K; Josephs M D; Abdalla E K; Mackay S L; Edwards C K; Copeland E M; Moldawer L L
Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha.
Infection and immunity 1998;66(4):1800-2.
-
1998: Solorzano C C; Kaibara A; Hess P J; Edwards P D; Ksontini R; Abouhamze A; McDaniel S; Frazier J; Trujillo D; Kieft G; Seely J; Kohno T; Cosenza M E; Clare-Salzler M; MacKay S L; Martin S W; Moldawer L L; Edwards C K
Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;84(4):1119-30.
-
1998: Edwards P D; Moldawer L L
Role of cytokines in the metabolic response to stress.
Current opinion in clinical nutrition and metabolic care 1998;1(2):187-90.
-
1998: Moldawer L L; Sattler F R
Human immunodeficiency virus-associated wasting and mechanisms of cachexia associated with inflammation.
Seminars in oncology 1998;25(1 Suppl 1):73-81.
-
1998: Xu B; Dube M G; Kalra P S; Farmerie W G; Kaibara A; Moldawer L L; Martin D; Kalra S P
Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin.
Endocrinology 1998;139(2):466-73.
-
1998: Denham W; Yang J; MacKay S; Tannahill C; Carter G; Abouhamze A; Moldawer L L; Norman J
Cationic liposome-mediated gene transfer during acute pancreatitis: tissue specificity, duration, and effects of acute inflammation.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1998;2(1):95-101.
-
1998: Kalra S P; Xu B; Dube M G; Moldawer L L; Martin D; Kalra P S
Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y.
Neuroscience letters 1998;240(1):45-9.
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1997: Labow M; Shuster D; Zetterstrom M; Nunes P; Terry R; Cullinan E B; Bartfai T; Solorzano C; Moldawer L L; Chizzonite R; McIntyre K W
Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2452-61.
-
1997: Edwards P D; Topping D; Kontaridis M I; Moldawer L L; Copeland E M; Lind D S
Arginine-enhanced enteral nutrition augments the growth of a nitric oxide-producing tumor.
JPEN. Journal of parenteral and enteral nutrition 1997;21(4):215-9.
-
1997: Hess P J; Seeger J M; Huber T S; Welborn M B; Martin T D; Harward T R; Duschek S; Edwards P D; Solorzano C C; Copeland E M; Moldawer L L
Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor-dependent murine model of acute visceral ischemia.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 1997;26(1):113-8.
-
1997: Solorzano C C; Ksontini R; Pruitt J H; Auffenberg T; Tannahill C; Galardy R E; Schultz G P; MacKay S L; Copeland E M; Moldawer L L
A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality.
Shock (Augusta, Ga.) 1997;7(6):427-31.
-
1997: Engles R E; Huber T S; Zander D S; Hess P J; Welborn M B; Moldawer L L; Seeger J M
Exogenous human recombinant interleukin-10 attenuates hindlimb ischemia-reperfusion injury.
The Journal of surgical research 1997;69(2):425-8.
-
1997: Lind D S; Kontaridis M I; Edwards P D; Josephs M D; Moldawer L L; Copeland E M
Nitric oxide contributes to adriamycin's antitumor effect.
The Journal of surgical research 1997;69(2):283-7.
-
1997: Moldawer L L; Copeland E M
Proinflammatory cytokines, nutritional support, and the cachexia syndrome: interactions and therapeutic options.
Cancer 1997;79(9):1828-39.
-
1997: Solorzano C C; Ksontini R; Pruitt J H; Hess P J; Edwards P D; Kaibara A; Abouhamze A; Auffenberg T; Galardy R E; Vauthey J N; Copeland E M; Edwards C K; Lauwers G Y; Clare-Salzler M; MacKay S L; Moldawer L L; Lazarus D D
Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):414-9.
-
1996: van der Poll T; Coyle S M; Moldawer L L; Lowry S F
Changes in endotoxin-induced cytokine production by whole blood after in vivo exposure of normal humans to endotoxin.
The Journal of infectious diseases 1996;174(6):1356-60.
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1996: Welborn M B; Douglas W G; Abouhamze Z; Auffenburg T; Abouhamze A S; Baumhofer J; Seeger J M; Pruitt J H; Edwards P D; Chizzonite R; Martin D; Moldawer L L; Harward T R
Visceral ischemia-reperfusion injury promotes tumor necrosis factor (TNF) and interleukin-1 (IL-1) dependent organ injury in the mouse.
Shock (Augusta, Ga.) 1996;6(3):171-6.
-
1996: van der Poll T; Jansen P M; Van Zee K J; Welborn M B; de Jong I; Hack C E; Loetscher H; Lesslauer W; Lowry S F; Moldawer L L
Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor.
Blood 1996;88(3):922-7.
-
1996: Espat N J; Auffenberg T; Rosenberg J J; Rogy M; Martin D; Fang C H; Hasselgren P O; Copeland E M; Moldawer L L
Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response.
The American journal of physiology 1996;271(1 Pt 2):R185-90.
-
1996: Welborn M B; Van Zee K; Edwards P D; Pruitt J H; Kaibara A; Vauthey J N; Rogy M; Castleman W L; Lowry S F; Kenney J S; Stüber D; Ettlin U; Wipf B; Loetscher H; Copeland E M; Lesslauer W; Moldawer L L
A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon.
The Journal of experimental medicine 1996;184(1):165-71.
-
1996: Edwards P; Cendan J C; Topping D B; Moldawer L L; MacKay S; Copeland EMIII; Lind D S
Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo.
The Journal of surgical research 1996;63(1):49-52.
-
1996: Harward T R; Welborn M B; Martin T D; Flynn T C; Huber T S; Moldawer L L; Seeger J M
Visceral ischemia and organ dysfunction after thoracoabdominal aortic aneurysm repair. A clinical and cost analysis.
Annals of surgery 1996;223(6):729-34; discussion 734-6.
-
1996: Espat N J; Auffenberg T; Abouhamze A; Baumhofer J; Moldawer L L; Howard R J
A role for tumor necrosis factor-alpha in the increased mortality associated with Vibrio vulnificus infection in the presence of hepatic dysfunction.
Annals of surgery 1996;223(4):428-33.
-
1996: Calvano S E; van der Poll T; Coyle S M; Barie P S; Moldawer L L; Lowry S F
Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(4):434-7.
-
1996: Pruitt J H; Welborn M B; Edwards P D; Harward T R; Seeger J W; Martin T D; Smith C; Kenney J A; Wesdorp R I; Meijer S; Cuesta M A; Abouhanze A; Copeland E M; Giri J; Sims J E; Moldawer L L; Oldenburg H S
Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome.
Blood 1996;87(8):3282-8.
-
1996: Van Zee K J; Moldawer L L; Oldenburg H S; Thompson W A; Stackpole S A; Montegut W J; Rogy M A; Meschter C; Gallati H; Schiller C D; Richter W F; Loetscher H; Ashkenazi A; Chamow S M; Wurm F; Calvano S E; Lowry S F; Lesslauer W
Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(6):2221-30.
-
1996: Rogy M A; Oldenburg H S; Coyle S; Trousdale R; Moldawer L L; Lowry S F
Correlation between Acute Physiology and Chronic Health Evaluation (APACHE) III score and immunological parameters in critically ill patients with sepsis.
The British journal of surgery 1996;83(3):396-400.
-
1996: Beierle E A; Vauthey J N; Moldawer L L; Copeland E M
Hepatic tumor necrosis factor-alpha production and distant organ dysfunction in a murine model of obstructive jaundice.
American journal of surgery 1996;171(1):202-6.
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1995: van der Poll T; Marchant A; Buurman W A; Berman L; Keogh C V; Lazarus D D; Nguyen L; Goldman M; Moldawer L L; Lowry S F
Endogenous IL-10 protects mice from death during septic peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5397-401.
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1995: van der Poll T; Calvano S E; Kumar A; Braxton C C; Coyle S M; Barbosa K; Moldawer L L; Lowry S F
Endotoxin induces downregulation of tumor necrosis factor receptors on circulating monocytes and granulocytes in humans.
Blood 1995;86(7):2754-9.
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1995: Oldenburg H S; Pruitt J H; Lazarus D D; Rogy M A; Chizzonite R; Lowry S F; Moldawer L L
Interleukin 1 binding to its type I, but not type II receptor, modulates the in vivo acute phase response.
Cytokine 1995;7(6):510-6.
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1995: van der Poll T; Fischer E; Coyle S M; Van Zee K J; Pribble J P; Stiles D M; Barie P S; Buurman W A; Moldawer L L; Lowry S F
Interleukin-1 contributes to increased concentrations of soluble tumor necrosis factor receptor type I in sepsis.
The Journal of infectious diseases 1995;172(2):577-80.
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1995: Jansen P M; Boermeester M A; Fischer E; de Jong I W; van der Poll T; Moldawer L L; Hack C E; Lowry S F
Contribution of interleukin-1 to activation of coagulation and fibrinolysis, neutrophil degranulation, and the release of secretory-type phospholipase A2 in sepsis: studies in nonhuman primates after interleukin-1 alpha administration and during lethal bacteremia.
Blood 1995;86(3):1027-34.
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1995: Remick D; Manohar P; Bolgos G; Rodriguez J; Moldawer L; Wollenberg G
Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture.
Shock (Augusta, Ga.) 1995;4(2):89-95.
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1995: MacKay S L; Yaswen L R; Tarnuzzer R W; Moldawer L L; Bland K I; Copeland E M; Schultz G S
Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors.
Annals of surgery 1995;221(6):767-76; discussion 776-7.
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1995: Rogy M A; Auffenberg T; Espat N J; Philip R; Remick D; Wollenberg G K; Copeland E M; Moldawer L L
Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses.
The Journal of experimental medicine 1995;181(6):2289-93.
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1995: van der Poll T; Van Zee K J; Endert E; Coyle S M; Stiles D M; Pribble J P; Catalano M A; Moldawer L L; Lowry S F
Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man.
The Journal of clinical endocrinology and metabolism 1995;80(4):1341-6.
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1995: Espat N J; Moldawer L L; Copeland E M
Cytokine-mediated alterations in host metabolism prevent nutritional repletion in cachectic cancer patients.
Journal of surgical oncology 1995;58(2):77-82.
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1995: Van Zee K J; Coyle S M; Calvano S E; Oldenburg H S; Stiles D M; Pribble J; Catalano M; Moldawer L L; Lowry S F
Influence of IL-1 receptor blockade on the human response to endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(3):1499-507.
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1994: Cendan J C; Moldawer L L; Souba W W; Copeland E M; Lind D S
Endotoxin-induced nitric oxide production in pulmonary artery endothelial cells is regulated by cytokines.
Archives of surgery (Chicago, Ill. : 1960) 1994;129(12):1296-300.
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1994: Espat N J; Copeland E M; Moldawer L L
Tumor necrosis factor and cachexia: a current perspective.
Surgical oncology 1994;3(5):255-62.
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1994: Rogy M A; Moldawer L L; Oldenburg H S; Thompson W A; Montegut W J; Stackpole S A; Kumar A; Palladino M A; Marra M N; Lowry S F
Anti-endotoxin therapy in primate bacteremia with HA-1A and BPI.
Annals of surgery 1994;220(1):77-85.
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1994: Espat N J; Rogy M A; Copeland E M; Moldawer L L
CMNSG Guest Lecture. Interleukin-1, interleukin-1 receptor, and interleukin-1 receptor antagonist.
The Proceedings of the Nutrition Society 1994;53(2):393-400.
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1994: Rogy M A; Oldenburg H S; Calvano S E; Montegut W J; Stackpole S A; Van Zee K J; Marra M N; Scott R W; Seilhammer J J; Moldawer L L
The role of bactericidal/permeability-increasing protein in the treatment of primate bacteremia and septic shock.
Journal of clinical immunology 1994;14(2):120-33.
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1994: Rogy M A; Coyle S M; Oldenburg H S; Rock C S; Barie P S; Van Zee K J; Smith C G; Moldawer L L; Lowry S F
Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients.
Journal of the American College of Surgeons 1994;178(2):132-8.
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1994: Fong Y; Matthews D E; He W; Marano M A; Moldawer L L; Lowry S F
Whole body and splanchnic leucine, phenylalanine, and glucose kinetics during endotoxemia in humans.
The American journal of physiology 1994;266(2 Pt 2):R419-25.
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1994: Calvano S E; Thompson W A; Marra M N; Coyle S M; de Riesthal H F; Trousdale R K; Barie P S; Scott R W; Moldawer L L; Lowry S F
Changes in polymorphonuclear leukocyte surface and plasma bactericidal/permeability-increasing protein and plasma lipopolysaccharide binding protein during endotoxemia or sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1994;129(2):220-6.
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1994: Thompson W A; Coyle S; Van Zee K; Oldenburg H; Trousdale R; Rogy M; Felsen D; Moldawer L; Lowry S F
The metabolic effects of platelet-activating factor antagonism in endotoxemic man.
Archives of surgery (Chicago, Ill. : 1960) 1994;129(1):72-9.
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1993: Oldenburg H S; Rogy M A; Lazarus D D; Van Zee K J; Keeler B P; Chizzonite R A; Lowry S F; Moldawer L L
Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6.
European journal of immunology 1993;23(8):1889-94.
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1993: Lazarus D D; Moldawer L L; Lowry S F
Insulin-like growth factor-1 activity is inhibited by interleukin-1 alpha, tumor necrosis factor-alpha, and interleukin-6.
Lymphokine and cytokine research 1993;12(4):219-23.
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1993: Hawes A S; Fischer E; Marano M A; Van Zee K J; Rock C S; Lowry S F; Calvano S E; Moldawer L L
Comparison of peripheral blood leukocyte kinetics after live Escherichia coli, endotoxin, or interleukin-1 alpha administration. Studies using a novel interleukin-1 receptor antagonist.
Annals of surgery 1993;218(1):79-90.
-
1993: Lowry S F; Moldawer L L
Modulation of cytokine responses in sepsis.
Annals of the New York Academy of Sciences 1993;685():471-82.
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1993: Barber A E; Coyle S M; Marano M A; Fischer E; Calvano S E; Fong Y; Moldawer L L; Lowry S F
Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(5):1999-2006.
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1993: Moldawer L L
Interleukin-1, TNF alpha and their naturally occurring antagonists in sepsis.
Blood purification 1993;11(2):128-33.
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1992: Moldawer L L; Rogy M A; Lowry S F
The role of cytokines in cancer cachexia.
JPEN. Journal of parenteral and enteral nutrition 1992;16(6 Suppl):43S-49S.
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1992: Fong Y; Moldawer L L; Lowry S F
Experimental and clinical applications of molecular cell biology in nutrition and metabolism.
JPEN. Journal of parenteral and enteral nutrition 1992;16(5):477-86.
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1992: Rock C S; Coyle S M; Keogh C V; Lazarus D D; Hawes A S; Leskiw M; Moldawer L L; Stein T P; Lowry S F
Influence of hypercortisolemia on the acute-phase protein response to endotoxin in humans.
Surgery 1992;112(2):467-74.
-
1992: Van Zee K J; Kohno T; Fischer E; Rock C S; Moldawer L L; Lowry S F
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4845-9.
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1992: He W; Fong Y; Marano M A; Gershenwald J E; Yurt R W; Moldawer L L; Lowry S F
Tolerance to endotoxin prevents mortality in infected thermal injury: association with attenuated cytokine responses.
The Journal of infectious diseases 1992;165(5):859-64.
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1992: Fischer E; Van Zee K J; Marano M A; Rock C S; Kenney J S; Poutsiaka D D; Dinarello C A; Lowry S F; Moldawer L L
Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease.
Blood 1992;79(9):2196-200.
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1992: Van Zee K J; Fischer E; Hawes A S; Hébert C A; Terrell T G; Baker J B; Lowry S F; Moldawer L L
Effects of intravenous IL-8 administration in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1746-52.
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1992: Ng E H; Rock C S; Lazarus D D; Stiaino-Coico L; Moldawer L L; Lowry S F
Insulin-like growth factor I preserves host lean tissue mass in cancer cachexia.
The American journal of physiology 1992;262(3 Pt 2):R426-31.
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1991: Fong Y M; Minei J P; Marano M A; Moldawer L L; Wei H; Shires G T; Shires G T; Lowry S F
Skeletal muscle amino acid and myofibrillar protein mRNA response to thermal injury and infection.
The American journal of physiology 1991;261(3 Pt 2):R536-42.
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1991: Ng E H; Rock C S; Lazarus D; Staiano-Coico L; Fischer E; Moldawer L L; Lowry S F
Impact of exogenous growth hormone on host preservation and tumor cell-cycle distribution in a rat sarcoma model.
The Journal of surgical research 1991;51(2):99-105.
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1991: Van Zee K J; DeForge L E; Fischer E; Marano M A; Kenney J S; Remick D G; Lowry S F; Moldawer L L
IL-8 in septic shock, endotoxemia, and after IL-1 administration.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3478-82.
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1990: Barber A E; Jones W G; Minei J P; Fahey T J; Moldawer L L; Rayburn J L; Fischer E; Keogh C V; Shires G T; Lowry S F
Harry M. Vars award. Glutamine or fiber supplementation of a defined formula diet: impact on bacterial translocation, tissue composition, and response to endotoxin.
JPEN. Journal of parenteral and enteral nutrition 1990;14(4):335-43.
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1990: Gershenwald J E; Fong Y M; Fahey T J; Calvano S E; Chizzonite R; Kilian P L; Lowry S F; Moldawer L L
Interleukin 1 receptor blockade attenuates the host inflammatory response.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):4966-70.
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1990: Fong Y M; Marano M A; Moldawer L L; Wei H; Calvano S E; Kenney J S; Allison A C; Cerami A; Shires G T; Lowry S F
The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans.
The Journal of clinical investigation 1990;85(6):1896-904.
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1990: Fong Y; Moldawer L L; Shires G T; Lowry S F
The biologic characteristics of cytokines and their implication in surgical injury.
Surgery, gynecology & obstetrics 1990;170(4):363-78.
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1990: Marano M A; Fong Y; Moldawer L L; Wei H; Calvano S E; Tracey K J; Barie P S; Manogue K; Cerami A; Shires G T
Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality.
Surgery, gynecology & obstetrics 1990;170(1):32-8.
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1990: Keogh C; Fong Y; Marano M A; Seniuk S; He W; Barber A; Minei J P; Felsen D; Lowry S F; Moldawer L L
Identification of a novel tumor necrosis factor alpha/cachectin from the livers of burned and infected rats.
Archives of surgery (Chicago, Ill. : 1960) 1990;125(1):79-84; discussion 85.
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1989: Fong Y; Tracey K J; Moldawer L L; Hesse D G; Manogue K B; Kenney J S; Lee A T; Kuo G C; Allison A C; Lowry S F
Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.
The Journal of experimental medicine 1989;170(5):1627-33.
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1989: Fong Y M; Marano M A; Barber A; He W; Moldawer L L; Bushman E D; Coyle S M; Shires G T; Lowry S F
Total parenteral nutrition and bowel rest modify the metabolic response to endotoxin in humans.
Annals of surgery 1989;210(4):449-56; discussion 456-7.
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1989: Fong Y; Moldawer L L; Marano M A; Wei H; Barber A; Fischman D A; Lowry S F
Starvation leads to decreased levels of mRNA for myofibrillar proteins.
The Journal of surgical research 1989;46(5):457-61.
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1989: Fong Y; Moldawer L L; Marano M; Wei H; Tatter S B; Clarick R H; Santhanam U; Sherris D; May L T; Sehgal P B
Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2321-4.
-
1989: Minei J P; Fong Y; Marano M A; Moldawer L L; Jones W G; Wei H; Richardson R P; Yurt R W; Shires G T; Lowry S F
Hepatocellular membrane function during chronic burn injury.
The Journal of surgical research 1989;46(4):311-6.
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1989: Fong Y; Moldawer L L; Marano M; Wei H; Barber A; Manogue K; Tracey K J; Kuo G; Fischman D A; Cerami A
Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins.
The American journal of physiology 1989;256(3 Pt 2):R659-65.
-
1989: Moldawer L L; Marano M A; Wei H; Fong Y; Silen M L; Kuo G; Manogue K R; Vlassara H; Cohen H; Cerami A
Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(5):1637-43.
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1989: Silen M L; Hesse D G; Felsen D; Moldawer L L; Calvano S E; Seniuk S; Cerami A; Lowry S F
Cachectin/tumor necrosis factor production by fetal and newborn rat hepatic macrophages.
Journal of pediatric surgery 1989;24(1):34-8; Discussion 38.
-
1988: Marano M A; Moldawer L L; Fong Y; Wei H; Minei J; Yurt R; Cerami A; Lowry S F
Cachectin/TNF production in experimental burns and Pseudomonas infection.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(11):1383-8.
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