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Agnese Molinari

Research Profile

Chemicals & Drugs

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Luana Lugini; Gianfranco Macchia; Agnese Molinari; Luisa Paris; Franca Podo; Carlo Ramoni; Licia Rivoltini; Francesca Spadaro; Laura Abalsamo; Serena Cecchetti; Marisa Colone; Veronica Huber; Francesca Luciani; Stefano Fais
Immune surveillance properties of human NK cell-derived exosomes.
Laura Abalsamo; Giuseppina Bozzuto; Serena Cecchetti; Egidio Iorio; Luana Lugini; Agnese Molinari; Luisa Paris; Carlo Ramoni; Francesca Spadaro; Franca Podo
Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells.
Paolo Grieco; renato franco; Giuseppina Bozzuto; Laura Toccacieli; Alessandro Sgambato; Monica Marra; Silvia Zappavigna; Mario Migaldi; Giulio Rossi; Stefano Striano; Luigi Marra; Luigi Gallo; Achille Cittadini; Gerardo Botti; Ettore Novellino; Agnese Molinari; Alfredo Budillon; Michele Caraglia
Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells.

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All Publications

2012: Luana Lugini; Gianfranco Macchia; Agnese Molinari; Luisa Paris; Franca Podo; Carlo Ramoni; Licia Rivoltini; Francesca Spadaro; Laura Abalsamo; Serena Cecchetti; Marisa Colone; Veronica Huber; Francesca Luciani; Stefano Fais
Immune surveillance properties of human NK cell-derived exosomes.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):2833-42.
2012: Laura Abalsamo; Giuseppina Bozzuto; Serena Cecchetti; Egidio Iorio; Luana Lugini; Agnese Molinari; Luisa Paris; Carlo Ramoni; Francesca Spadaro; Franca Podo
Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells.
Breast cancer research : BCR 2012;14(2):R50.
2011: Paolo Grieco; renato franco; Giuseppina Bozzuto; Laura Toccacieli; Alessandro Sgambato; Monica Marra; Silvia Zappavigna; Mario Migaldi; Giulio Rossi; Stefano Striano; Luigi Marra; Luigi Gallo; Achille Cittadini; Gerardo Botti; Ettore Novellino; Agnese Molinari; Alfredo Budillon; Michele Caraglia
Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells.
Journal of cellular biochemistry 2011;112(1):341-53.
2011: Giuseppina Bozzuto; Marisa Colone; Laura Toccacieli; Annarita Stringaro; Agnese Molinari
Tea tree oil might combat melanoma.
Planta medica 2011;77(1):54-6.
2010: Marisa Colone; G Marelli; V Unfer; G Bozzuto; Agnese Molinari; Annarita Stringaro
Inositol activity in oligoasthenoteratospermia--an in vitro study.
European review for medical and pharmacological sciences 2010;14(10):891-6.
2010: Cecilia Bombelli; Annarita Stringaro; Stefano Borocci; Giuseppina Bozzuto; Marisa Colone; Luisa Giansanti; Rosa Sgambato; Laura Toccaceli; Giovanna Mancini; Agnese Molinari
Efficiency of liposomes in the delivery of a photosensitizer controlled by the stereochemistry of a gemini surfactant component.
Molecular pharmaceutics 2010;7(1):130-7.
2010: Francesca Carlini; Barbara Ridolfi; Agnese Molinari; Chiara Parisi; Giuseppina Bozzuto; Laura Toccacieli; Giuseppe Formisano; Daniela De Orsi; Silvia Paradisi; Olì Maria Victoria Grober; Maria Ravo; Alessandro Weisz; Romano Arcieri; Stefano Vella; Simona Gaudi
The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines.
PloS one 2010;5(12):e14221.
2010: Giuseppina Bozzuto; Paola Ruggieri; Agnese Molinari
Molecular aspects of tumor cell migration and invasion.
Annali dell'Istituto superiore di sanità 2010;46(1):66-80.
2009: Isabella Parolini; Cristina Federici; Carla Raggi; Luana Lugini; Simonetta Palleschi; Angelo De Milito; Carolina Coscia; Elisabetta Iessi; Mariantonia Logozzi; Agnese Molinari; Marisa Colone; Massimo Tatti; Massimo Sargiacomo; Stefano Fais
Microenvironmental pH is a key factor for exosome traffic in tumor cells.
The Journal of biological chemistry 2009;284(49):34211-22.
2009: Enzo Agostinelli; Maria Condello; Agnese Molinari; Giampiero Tempera; Nikenza Viceconte; Giuseppe Arancia
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.
International journal of oncology 2009;35(3):485-98.
2008: Marisa Colone; Annarica Calcabrini; Laura Toccacieli; Giuseppina Bozzuto; Annarita Stringaro; Massimo Gentile; Maurizio Cianfriglia; Alessandra Ciervo; Michele Caraglia; Alfredo Budillon; Giuseppina Meo; Giuseppe Arancia; Agnese Molinari
The multidrug transporter P-glycoprotein: a mediator of melanoma invasion?
The Journal of investigative dermatology 2008;128(4):957-71.
2008: Stefano Mannino; Agnese Molinari; Giovanni Sabatino; Silvia Anna Ciafrè; M Colone; Giulio Maira; C Anile; Giuseppe Arancia; Annunziato Mangiola
Intratumoral vs systemic administration of meta-tetrahydroxyphenylchlorin for photodynamic therapy of malignant gliomas: assessment of uptake and spatial distribution in C6 rat glioma model.
International journal of immunopathology and pharmacology 2008;21(1):227-31.
2007: Enrico P Spugnini; Giuseppe Arancia; Alessandro Porrello; Marisa Colone; Giuseppe Formisano; Annarita Stringaro; Gennaro Citro; Agnese Molinari
Ultrastructural modifications of cell membranes induced by "electroporation" on melanoma xenografts.
Microscopy research and technique 2007;70(12):1041-50.
2007: Agnese Molinari; Cecilia Bombelli; Stefano Mannino; Annarita Stringaro; Laura Toccacieli; Annarica Calcabrini; Marisa Colone; Annunziato Mangiola; Giulio Maira; Paola Luciani; Giovanna Mancini; Giuseppe Arancia
m-THPC-mediated photodynamic therapy of malignant gliomas: assessment of a new transfection strategy.
International journal of cancer. Journal international du cancer 2007;121(5):1149-55.
2007: Agnese Molinari; Marisa Colone; Annarica Calcabrini; Annarita Stringaro; Laura Toccacieli; Giuseppe Arancia; Stefano Mannino; Annunziato Mangiola; Giulio Maira; Cecilia Bombelli; Giovanna Mancini
Cationic liposomes, loaded with m-THPC, in photodynamic therapy for malignant glioma.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(2):230-4.
2007: Maurizio Cianfriglia; Maria Luisa Dupuis; Agnese Molinari; Antonio Verdoliva ; Roberta Costi; Clementina M Galluzzo; Mauro Andreotti; Andrea Cara; Roberto Di Santo; Lucia Palmisano
HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein.
Retrovirology 2007;4():17.
2006: Paola Turella; Giuseppe Filomeni; Maria Luisa Dupuis; Maria Rosa Ciriolo; Agnese Molinari; Francesca De Maria; Marina Tombesi; Maurizio Cianfriglia; Giorgio Federici; Giorgio Ricci; Anna Maria Caccuri
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.
The Journal of biological chemistry 2006;281(33):23725-32.
2006: Cristiano Giordani; Agnese Molinari; Laura Toccacieli; Annarica Calcabrini; Annarita Stringaro; Pietro Chistolini; Giuseppe Arancia; Marco Diociaiuti
Interaction of tea tree oil with model and cellular membranes.
Journal of medicinal chemistry 2006;49(15):4581-8.
2005: Cecilia Bombelli; Giulio Caracciolo; Pietro Di Profio; Marco Diociaiuti; Paola Luciani; Giovanna Mancini; Claudia Mazzuca; Manuela Marra; Agnese Molinari; Donato Monti; Laura Toccacieli; Mariano Venanzi
Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physicochemical and biological features of the complexes.
Journal of medicinal chemistry 2005;48(15):4882-91.
2005: Agnese Molinari; Annarita Stringaro; Massimo Gentile; Marisa Colone; Laura Toccacieli; Giuseppe Arancia
Invasive properties of multidrug resistant human melanoma cells.
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 2005;110(2 Suppl 1):135-41.
2004: Francesca Luciani; Massimo Spada; Angelo De Milito; Agnese Molinari; Licia Rivoltini; Annalisa Montinaro; Manuela Marra; Luana Lugini; Mariantonia Logozzi; Francesco Lozupone; Cristina Federici; Elisabetta Iessi; Giorgio Parmiani; Giuseppe Arancia; Filippo Belardelli; Stefano Fais
Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs.
Journal of the National Cancer Institute 2004;96(22):1702-13.
2004: Annarica Calcabrini; Annarita Stringaro; Laura Toccacieli; Stefania Meschini; Manuela Marra; Marisa Colone; Giuseppe Salvatore; Francesca Mondello; Giuseppe Arancia; Agnese Molinari
Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells.
The Journal of investigative dermatology 2004;122(2):349-60.
2003: Maria Luisa Dupuis; Michela Flego; Agnese Molinari; Maurizio Cianfriglia
Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells.
HIV medicine 2003;4(4):338-45.
2002: Agnese Molinari; Annarica Calcabrini; Stefania Meschini; Annarita Stringaro; Pasqualina Crateri; Laura Toccacieli; Manuela Marra; Marisa Colone; Maurizio Cianfriglia; Giuseppe Arancia
Subcellular detection and localization of the drug transporter P-glycoprotein in cultured tumor cells.
Current protein & peptide science 2002;3(6):653-70.
2002: Marco Diociaiuti; Federico Bordi; Annelisa Motta; Alessandra Carosi; Agnese Molinari; Giuseppe Arancia; Carlo Coluzza
Aggregation of gramicidin A in phospholipid Langmuir-Blodgett monolayers.
Biophysical journal 2002;82(6):3198-206.
2002: Giovanna Andreola; Licia Rivoltini; Chiara Castelli; Veronica Huber; Paola Perego; Paola Deho; Paola Squarcina; Paola Accornero; Francesco Lozupone; Luana Lugini; Annarita Stringaro; Agnese Molinari; Giuseppe Arancia; Massimo Gentile; Giorgio Parmiani; Stefano Fais
Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.
The Journal of experimental medicine 2002;195(10):1303-16.
2002: Agnese Molinari; Annarica Calcabrini; Stefania Meschini; Manuela Marra; Annarita Stringaro; Laura Toccacieli; Maurizio Cianfriglia; Giuseppe Arancia
What is the relationship between P-glycoprotein and adhesion molecule expression in melanoma cells?
Melanoma research 2002;12(2):109-14.
2002: Marco Diociaiuti; Agnese Molinari; Irene Ruspantini; Maria Cristina Gaudiano; Rodolfo Ippoliti; Eugenio Lendaro; Federico Bordi; Pietro Chistolini; Giuseppe Arancia
P-glycoprotein inserted in planar lipid bilayers formed by liposomes opened on amorphous carbon and Langmuir-Blodgett monolayer.
Biochimica et biophysica acta 2002;1559(1):21-31.
2002: Francesca Luciani; Agnese Molinari; Francesco Lozupone; Annarica Calcabrini; Luana Lugini; Annarita Stringaro; Patrizia Puddu; Giuseppe Arancia; Maurizio Cianfriglia; Stefano Fais
P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin.
Blood 2002;99(2):641-8.
2002: Annarita Stringaro; Agnese Molinari; Annarica Calcabrini; Giuseppe Arancia; Pier Giuseppe Ceddia; Maurizio Cianfriglia; Francesca Poloni; Francesca Mondello; Letizia Angiolella; Flavia De Bernardis; Antonio Cassone
Detection of human P-glycoprotein-like molecule in azole-resistant Candida albicans from HIV+ patients.
Microbial drug resistance (Larchmont, N.Y.) 2002;8(3):235-44.
2001: Irene Ruspantini; Marco Diociaiuti; Rodolfo Ippoliti; Eugenio Lendaro; Maria Cristina Gaudiano; Maurizio Cianfriglia; Pietro Chistolini; Giuseppe Arancia; Agnese Molinari
Immunogold localisation of P-glycoprotein in supported lipid bilayers by transmission electron microscopy and atomic force microscopy.
The Histochemical journal 2001;33(5):305-9.
2001: Massimo Di Vito; Luisa Lenti; Arno Knijn; Egidio Iorio; F d'Agostino; Agnese Molinari; Annarica Calcabrini; Annarita Stringaro; Stefania Meschini; Giuseppe Arancia; Argante Bozzi; Roberto Strom; Franca Podo
1H NMR-visible mobile lipid domains correlate with cytoplasmic lipid bodies in apoptotic T-lymphoblastoid cells.
Biochimica et biophysica acta 2001;1530(1):47-66.
2001: Giuseppe Arancia; Agnese Molinari; Annarica Calcabrini; Stefania Meschini; Maurizio Cianfriglia
Intracellular P-glycoprotein in multidrug resistant tumor cells.
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 2001;106(2 Suppl 1):59-68.
2000: Annarica Calcabrini; Stefania Meschini; Annarita Stringaro; Maurizio Cianfriglia; Giuseppe Arancia; Agnese Molinari
Detection of P-glycoprotein in the nuclear envelope of multidrug resistant cells.
The Histochemical journal 2000;32(10):599-606.
2000: Agnese Molinari; Laura Toccacieli; Annarica Calcabrini; Marco Diociaiuti; Maurizio Cianfriglia; Giuseppe Arancia
Induction of P-glycoprotein expression on the plasma membrane of human melanoma cells.
Anticancer research 2000;20(4):2691-6.
2000: Marina Cerquetti; Agnese Molinari; Annalisa Sebastianelli; Marco Diociaiuti; Raffaele Petruzzelli; C Capo; Paola Mastrantonio
Characterization of surface layer proteins from different Clostridium difficile clinical isolates.
Microbial pathogenesis 2000;28(6):363-72.
1999: Federico Bordi; Cesare Cametti; A Motta; Marco Diociaiuti; Agnese Molinari
Interactions of anthracyclines with zwitterionic phospholipid monolayers at the air-water interface.
Bioelectrochemistry and bioenergetics (Lausanne, Switzerland) 1999;49(1):51-6.
1999: Amalia Ferretti; Arno Knijn; Egidio Iorio; Simonetta Pulciani; M Giambenedetti; Agnese Molinari; Stefania Meschini; Annarita Stringaro; Annarica Calcabrini; I Freitas; Roberto Strom; Giuseppe Arancia; Franca Podo
Biophysical and structural characterization of 1H-NMR-detectable mobile lipid domains in NIH-3T3 fibroblasts.
Biochimica et biophysica acta 1999;1438(3):329-48.
1998: Agnese Molinari; Annarica Calcabrini; Stefania Meschini; Annarita Stringaro; D Del Bufalo; Maurizio Cianfriglia; Giuseppe Arancia
Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells.
International journal of cancer. Journal international du cancer 1998;75(6):885-93.
1997: Arno Knijn; Amalia Ferretti; P J Zhang; M Giambenedetti; Agnese Molinari; Stefania Meschini; Simonetta Pulciani; Franca Podo
Lower levels of 1H MRS-visible mobile lipids in H-ras transformed tumorigenic fibroblasts with respect to their untransformed parental cells.
Cellular and molecular biology (Noisy-le-Grand, France) 1997;43(5):691-701.
1997: Ersilia Dolfini; T Dasdia; Giuseppe Arancia; Agnese Molinari; Annarica Calcabrini; R J Scheper; M J Flens; Marzia B Gariboldi; Eugenio Monti
Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin.
British journal of cancer 1997;76(1):67-76.
1997: Annarica Calcabrini; Anna Maria Villa; Agnese Molinari; Silvia Maria Doglia; Giuseppe Arancia
Influence of N-methylformamide on the intracellular transport of doxorubicin.
European journal of cell biology 1997;72(1):61-9.
1996: Paolo Sarti; Patrizia Ginobbi; I D'Agostino; G Arancia; Eugenio Lendaro; Agnese Molinari; Rodolfo Ippoliti; Gennaro Citro
Liposomal targeting of leukaemia HL60 cells induced by transferrin-receptor endocytosis.
Biotechnology and applied biochemistry 1996;24 ( Pt 3)():269-76.
1995: Paolo Sarti; Agnese Molinari; G Arancia; Aurelia Meloni-Ehrig; Gennaro Citro
A modified spectroscopic method for the determination of the transbilayer distribution of phosphatidylethanolamine in soya-bean asolectin small unilamellar vesicles.
The Biochemical journal 1995;312 ( Pt 2)():643-8.
1995: Giuseppe Arancia; Federico Bordi; Annarica Calcabrini; Marco Diociaiuti; Agnese Molinari
Ultrastructural and spectroscopic methods in the study of anthracycline-membrane interaction.
Pharmacological research : the official journal of the Italian Pharmacological Society 1995;32(5):255-72.
1995: Gabriella Zupi; Agnese Molinari; Igea D'Agnano; Stefania Meschini; Donatella Del Bufalo; Paola Matarrese; A Candiloro; Annarica Calcabrini; Gennaro Citro; Giuseppe Arancia
Adriamycin resistance modulation induced by lonidamine in human breast cancer cells.
Anticancer research 1995;15(6B):2469-77.
1995: Giuseppe Arancia; Agnese Molinari; Pasqualina Crateri; Annarita Stringaro; Carlo Ramoni; Maria Luisa Dupuis; MJ Gomez; Antonella Torosantucci; Antonio Cassone
Noninhibitory binding of human interleukin-2-activated natural killer cells to the germ tube forms of Candida albicans.
Infection and immunity 1995;63(1):280-8.
1995: M Buscaglia; L Ghisoni; Maria Grazia Bellotti; Anna Maria Marconi; P Zamperini; L Stripparo; Agnese Molinari; M G Grimoldi; F Rossella
Genetic amniocentesis in biamniotic twin pregnancies by a single transabdominal insertion of the needle.
Prenatal diagnosis 1995;15(1):17-9.
1994: Agnese Molinari; Maurizio Cianfriglia; Stefania Meschini; Annarica Calcabrini; Giuseppe Arancia
P-glycoprotein expression in the Golgi apparatus of multidrug-resistant cells.
International journal of cancer. Journal international du cancer 1994;59(6):789-95.
1994: Stefania Meschini; Agnese Molinari; Annarica Calcabrini; Gennaro Citro; Giuseppe Arancia
Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study.
Journal of microscopy 1994;176(Pt 3):204-10.
1994: Silvia M Sirchia; C De Andreis; S Pariani; M G Grimoldi; Agnese Molinari; M Buscaglia; Giuseppe Simoni
Chromosome 14 maternal uniparental disomy in the euploid cell line of a fetus with mosaic 46,XX/47,XX,+14 karyotype.
Human genetics 1994;94(4):355-8.
1994: Paolo Sarti; Giovanni Antonini; Giuseppe Arancia; Thomas J J Blanck; Gennaro Citro; Aurelia Meloni-Ehrig; Agnese Molinari; Francesco Malatesta
Lonidamine-mediated respiratory changes in rat heart myocytes: a re-examination of the functional response of mitochondrial cytochrome c oxidase.
Biochemical pharmacology 1994;47(12):2221-5.
1994: Giuseppe Arancia; Agnese Molinari; Annarica Calcabrini; Gennaro Citro; Anna Maria Villa; Alessandra Verdina; Gabriella Zupi
Effects of sequential combinations of N-methylformamide with adriamycin on cultured melanoma cells (M14).
Experimental and molecular pathology 1994;60(1):12-26.
1994: Flavia De Bernardis; Agnese Molinari; Maria Boccanera; Annarita Stringaro; R Robert; J M Senet; Giuseppe Arancia; Antonio Cassone
Modulation of cell surface-associated mannoprotein antigen expression in experimental candidal vaginitis.
Infection and immunity 1994;62(2):509-19.
1993: Agnese Molinari; MJ Gomez; Pasqualina Crateri; Antonella Torosantucci; Antonio Cassone; Giuseppe Arancia
Differential cell surface expression of mannoprotein epitopes in yeast and mycelial forms of Candida albicans.
European journal of cell biology 1993;60(1):146-53.
1991: Marco Diociaiuti; Agnese Molinari; Annarica Calcabrini; Giuseppe Arancia
Electron energy-loss spectroscopy analysis of adriamycin-plasma membrane interaction.
Journal of microscopy 1991;164(Pt 2):95-106.
1991: Agnese Molinari; Annarica Calcabrini; Pasqualina Crateri; Giuseppe Arancia
Effects of daunomycin on the microtubular network: a cytochemical study on a human melanoma cell line.
European journal of cell biology 1991;54(2):291-8.
1990: Agnese Molinari; Annarica Calcabrini; Pasqualina Crateri; Giuseppe Arancia
Interaction of anthracyclinic antibiotics with cytoskeletal components of cultured carcinoma cells (CG5).
Experimental and molecular pathology 1990;53(1):11-33.
1989: S Stioui; M de Silvestris; Agnese Molinari; L Stripparo; L Ghisoni; Giuseppe Simoni
Trisomic 22 placenta in a case of severe intrauterine growth retardation.
Prenatal diagnosis 1989;9(9):673-6.
1988: Giuseppe Arancia; Agnese Molinari; Pasqualina Crateri; Annarica Calcabrini; L Silvestri; G Isacchi
Adriamycin-plasma membrane interaction in human erythrocytes.
European journal of cell biology 1988;47(2):379-87.
1988: Agnese Molinari; Graziella Orefici; Gianfranco Donelli; Christina von Hunolstein; Silvia Paradisi; Giuseppe Arancia
Preservation of capsular material of streptococcal cells by specific lectins determined by immunoelectron microscopy.
The Histochemical journal 1988;20(9):526-30.
1987: Agnese Molinari; Giuseppe Formisano; Walter Malorni
Modification of the cell surface expression of histocompatibility antigens induced by the neurotoxin 2,5 hexanedione.
Cell biology and toxicology 1987;3(4):417-30.
1987: Graziella Orefici; Agnese Molinari; Christina von Hunolstein; Gianfranco Donelli; Silvia Paradisi; Simona Recchia; Giuseppe Arancia
Pathogenic factors in group B streptococci types IV and V.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy 1987;6(2 Suppl):19-21.
1987: Walter Malorni; Giuseppe Formisano; Agnese Molinari
In vitro effects of 2,5 hexanedione on a melanoma cell line: a morphological study.
Toxicology 1987;43(3):269-82.
1984: Agnese Molinari; Giuseppe Arancia; G Donelli
[Immunologic localizations in electronic microscopy].
Annali dell'Istituto superiore di sanità 1984;20(2-3):171-91.