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Alfredo Molinolo

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Panomwat Amornphimoltham; J Silvio Gutkind; Kantima Leelahavanichkul; Andrius Masedunskas; Alfredo A Molinolo; Vyomesh Patel; Kamil Rechache; Jamie Thompson; Roberto Weigert
Rab25 regulates invasion and metastasis in head and neck cancer.
Vyomesh Patel; James F Rusling; Bhuvanesh Singh; Uttam K Sinha; Timothy D Veenstra; Ruchika Malhotra; Christina A Marsh; Daniel Martin; Alfredo A Molinolo; Cherie-Ann Nathan; Colleen L Doçi; J Silvio Gutkind
DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.
Shashank J Patel; Silvio Gutkind; Alfredo A Molinolo; Nigel P S Crawford
Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma.

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All Publications

2013: Panomwat Amornphimoltham; J Silvio Gutkind; Kantima Leelahavanichkul; Andrius Masedunskas; Alfredo A Molinolo; Vyomesh Patel; Kamil Rechache; Jamie Thompson; Roberto Weigert
Rab25 regulates invasion and metastasis in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1375-88.
2013: Vyomesh Patel; James F Rusling; Bhuvanesh Singh; Uttam K Sinha; Timothy D Veenstra; Ruchika Malhotra; Christina A Marsh; Daniel Martin; Alfredo A Molinolo; Cherie-Ann Nathan; Colleen L Doçi; J Silvio Gutkind
DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.
Oral oncology 2013;49(2):93-101.
2013: Shashank J Patel; Silvio Gutkind; Alfredo A Molinolo; Nigel P S Crawford
Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma.
PloS one 2013;8(4):e61848.
2012: Norberto A Gandini; J Silvio Gutkind; Alfredo A Molinolo; Vyomesh Patel; Débora G Salomón; Jorge Blasco; María M Facchinetti; María E Fermento; Alejandro Curino
Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas.
Experimental and molecular pathology 2012;93(2):237-45.
2012: Ramiro Iglesias-Bartolome; Kantima Leelahavanichkul; James B Mitchell; Alfredo A Molinolo; Vyomesh Patel; Ana Cotrim; J Silvio Gutkind
mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.
Cell stem cell 2012;11(3):401-14.
2012: Trisha M Wise-Draper; Kathryn Ann Wikenheiser-Brokamp; David J Draper; J Silvio Gutkind; Alfredo A Molinolo; Susanne I Wells
Future directions and treatment strategies for head and neck squamous cell carcinomas.
Translational research : the journal of laboratory and clinical medicine 2012;160(3):167-77.
2012: P Kosa; Alfredo A Molinolo; Roman Szabo; Thomas H Bugge
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis.
Oncogene 2012;31(32):3679-95.
2012: Anna Tamburrino; Samuel A Wells; Liqiang Xi; Rebecca D Chernock; J Silvio Gutkind; Jeffrey F Moley; Alfredo A Molinolo; Mark Raffeld; Paolo Salerno; Massimo Santoro
Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(13):3532-40.
2012: Alison M Boyce; Christine E Chamberlain; Natasha Cherman; William H Chong; Michelle Ellsworth; Frances A Farley; Rachel I Gafni; Josephine Z Kasa-Vubu; Marilyn H Kelly; Alfredo A Molinolo; Jack Yao; Carol Bassim; Nisan Bhattacharyya; Michael T Collins
Denosumab treatment for fibrous dysplasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(7):1462-70.
2012: Diane E Peters; Roman Szabo; Yi Zhang; Thomas H Bugge; Stephen H Leppla; Sharmina Miller-Randolph; Alfredo A Molinolo; Shihui Liu
Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis.
Biochemical and biophysical research communications 2012;422(3):393-7.
2012: Claudia Lanari; Paola Rojas; Victoria Wargon; Alfredo A Molinolo
Antiprogestins in breast cancer treatment: are we ready?
Endocrine-related cancer 2012;19(3):R35-50.
2012: Juan Pablo Cerliani; Stephen M Hewitt; María C Bottino; Claudia Lanari; Rubén Martins; Alfredo A Molinolo; Myriam Nuñez; Cecilia Pérez Piñero; Ana Sahores; Silvia I Vanzulli; Romina Varchetta; Eduardo Zeitlin; Caroline A Lamb
Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer.
Breast cancer research and treatment 2012;133(3):997-1008.
2012: Alfredo A Molinolo; Vyomesh Patel; Tanguy Seiwert; Mohamed El Dinali; Nitin Gangane; Stephen Hewitt; Kaitlin Jennison; Christina Marsh; J Silvio Gutkind
mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(9):2558-68.
2012: Sebastián Giulianelli; J Silvio Gutkind; Luisa Helguero; Caroline A Lamb; Rubén Martins; Alfredo A Molinolo; Rocío Soldati; Silvia I Vanzulli; José P Vaqué; Victoria Wargon; Eduardo Zeitlin; Claudia Lanari
Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters.
Cancer research 2012;72(9):2416-27.
2012: Lynn Vitale-cross; Rania H Younis; Wanjun Chen; Daniel Martin; Takashi Maruyama; Alfredo A Molinolo; Vyomesh Patel; Abraham Schneider; J Silvio Gutkind
Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions.
Cancer prevention research (Philadelphia, Pa.) 2012;5(4):562-73.
2012: Sebastián Giulianelli; J Silvio Gutkind; Luisa Helguero; Caroline Lamb; Rubén Martins; Alfredo A Molinolo; Rocío Soldati; Silvia I Vanzulli; José P Vaqué; Victoria Wargon; Eduardo Zeitlin; Claudia Lanari
[The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins].
Medicina 2012;72(4):315-20.
2011: Vyomesh Patel; Bhuvanesh Singh; Roberto Weigert; Cherie Ann Nathan; Christina A Marsh; Andrius Masedunskas; Constantinos M Mikelis; Alfredo A Molinolo; Cherie-Ann Nathan; Panomwat Amornphimoltham; Robert T Dorsam; J Silvio Gutkind
Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer.
Cancer research 2011;71(22):7103-12.
2011: Hiroshi Yagi; Panomwat Amornphimoltham; Sylvain Armando; Michel Bouvier; Patricia Dillenburg-Pilla; Alfredo A Molinolo; May Simaan; Wenfu Tan; Roberto Weigert; J Silvio Gutkind
A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.
Science signaling 2011;4(191):ra60.
2011: Sebastián Giulianelli; J Silvio Gutkind; Jason I Herschkowitz; Caroline A Lamb; Alfredo A Molinolo; Vyomesh Patel; Charles M Perou; Claudia Lanari
MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements.
Breast cancer research and treatment 2011;129(1):49-67.
2011: Daniel Martin; Alfredo A Molinolo; Reinhard Wetzker; Rebeca Galisteo; Emilio Hirsch; J Silvio Gutkind
PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.
Cancer cell 2011;19(6):805-13.
2011: William H Chong; Clara C Chen; Alfredo A Molinolo; Michael T Collins
Tumor-induced osteomalacia.
Endocrine-related cancer 2011;18(3):R53-77.
2011: Roman Szabo; A L Rasmussen; A B Moyer; P Kosa; J M Schafer; Alfredo A Molinolo; J Silvio Gutkind; Thomas H Bugge
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase.
Oncogene 2011;30(17):2003-16.
2011: María Cecilia Bottino; Juan Pablo Cerliani; Paola Rojas; Sebastián Giulianelli; Rocío Soldati; Carolina Mondillo; María Alicia Gorostiaga; Omar P Pignataro; Juan Carlos Calvo; J Silvio Gutkind; Alfredo A Molinolo; Isabel A Lüthy; Claudia Lanari
Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects.
Breast cancer research and treatment 2011;126(3):621-36.
2011: Vyomesh Patel; Bradford Siegele; Ramiro Iglesias-Bartolome; Kantima Leelahavanichkul; Christina A Marsh; Alfredo A Molinolo; J Silvio Gutkind
Cellular systems for studying human oral squamous cell carcinomas.
Advances in experimental medicine and biology 2011;720():27-38.
2011: Katiuchia Uzzun Sales; Maham F Shah; Roman Szabo; Rebecca Wagenaar-Miller; Alexandra Bey; John P Hobson; Alfredo A Molinolo; Amber L Rasmussen; Thomas H Bugge
Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.
PloS one 2011;6(8):e23261.
2011: Jeffrey M Schafer; Stephen H Leppla; Shihui Liu; Alfredo A Molinolo; Thomas Morley; Diane E Peters; Thomas H Bugge
Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin.
PloS one 2011;6(5):e20532.
2010: Ashwin A Bhirde; Sachin Patel; Alioscka A Sousa; Vyomesh Patel; Alfredo A Molinolo; Youngmi Ji; Richard Leapman; J Silvio Gutkind; James F Rusling
Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice.
Nanomedicine (London, England) 2010;5(10):1535-46.
2010: Aline Correa Abrahao; Rogerio M Castilho; Cristiane H Squarize; Alfredo A Molinolo; Decio dos Santos-Pinto; J Silvio Gutkind
A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.
Oral oncology 2010;46(12):880-7.
2010: Rocío Soldati; Victoria Wargon; Juan Pablo Cerliani; Sebastián Giulianelli; Silvia Inés Vanzulli; María Alicia Gorostiaga; Julieta Bolado; Pablo do Campo; Alfredo A Molinolo; Günter Vollmer; Claudia Lanari
Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?
Breast cancer research and treatment 2010;123(3):709-24.
2010: Brian M Connolly; Eun Young Choi; Henrik Gårdsvoll; Alexandra L Bey; Brooke M Currie; Triantafyllos Chavakis; Shihui Liu; Alfredo A Molinolo; Michael Ploug; Stephen H Leppla; Thomas H Bugge
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation.
Blood 2010;116(9):1593-603.
2010: Tao Ma; Bruno C Jham; Jiadi Hu; Eitan R Friedman; John Basile; Alfredo A Molinolo; Akrit S Sodhi; Silvia Montaner
Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14363-8.
2010: Ruslan Novosyadlyy; Danielle E Lann; Archana Vijayakumar; Anne Rowzee; Deborah A Lazzarino; Yvonne Fierz; Joan M Carboni; Marco M Gottardis; Patricia A Pennisi; Alfredo A Molinolo; Naamit Kurshan; Wilson Mejia; Stefania Santopietro; Shoshana Yakar; Teresa L Wood; Derek LeRoith
Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes.
Cancer research 2010;70(2):741-51.
2010: Juan Pablo Cerliani; Sebastián Giulianelli; Ana Sahores; Victoria Wargon; Adrian Gongora; Alberto Baldi; Alfredo A Molinolo; Caroline E Lamb; Claudia Lanari
Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia.
Medicina 2010;70(6):529-32.
2010: Victoria T Fabris; Ana Sahores; Silvia I Vanzulli; Lucas Colombo; Alfredo A Molinolo; Claudia Lanari; Caroline A Lamb
Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth.
BMC cancer 2010;10():293.
2009: Monika Sramkova; Andrius Masedunskas; Laura Parente; Alfredo A Molinolo; Roberto Weigert
Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals.
American journal of physiology. Cell physiology 2009;297(6):C1347-57.
2009: Karin List; Peter Kosa; Roman Szabo; Alexandra L Bey; Chao Becky Wang; Alfredo A Molinolo; Thomas H Bugge
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.
The American journal of pathology 2009;175(4):1453-63.
2009: Victoria Wargon; Luisa Helguero; Julieta Bolado; Paola Rojas; Virginia Novaro; Alfredo A Molinolo; Claudia Lanari
Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas.
Breast cancer research and treatment 2009;116(3):449-60.
2009: Yansong Bian; Anita Terse; Juan Du; Bradford Hall; Alfredo A Molinolo; Pin Zhang; Wanjun Chen; Kathleen C Flanders; J Silvio Gutkind; Lalage M Wakefield; Ashok B Kulkarni
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.
Cancer research 2009;69(14):5918-26.
2009: Claudia Lanari; Caroline A Lamb; Victoria Fabris; Luisa Helguero; Rocío Soldati; María Cecilia Bottino; Sebastián Giulianelli; Juan Pablo Cerliani; Victoria Wargon; Alfredo A Molinolo
The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.
Endocrine-related cancer 2009;16(2):333-50.
2009: Ana R Raimondi; Alfredo A Molinolo; J Silvio Gutkind
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model.
Cancer research 2009;69(10):4159-66.
2009: Lynn Vitale-cross; Rakefet Czerninski; Panomwat Amornphimoltham; Vyomesh Patel; Alfredo A Molinolo; J Silvio Gutkind
Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer.
Cancer prevention research (Philadelphia, Pa.) 2009;2(5):419-22.
2009: Lavanya H Palavalli; Todd D Prickett; John R Wunderlich; Xiaomu Wei; Allison S Burrell; Patricia Porter-Gill; Sean Davis; Chenwei Wang; Julia C Cronin; Neena S Agrawal; Jimmy C Lin; Wendy Westbroek; Shelley Hoogstraten-Miller; Alfredo A Molinolo; Patricia Fetsch; Armando C Filie; Michael O'Connell; Carolyn E Banister; Jason D Howard; Phillip Buckhaults; Ashani T Weeraratna; Lawrence C Brody; STEVEN ROSENBERG; Yardena Samuels
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
Nature genetics 2009;41(5):518-20.
2009: Alfredo A Molinolo; Panomwat Amornphimoltham; Cristiane H Squarize; Rogerio M Castilho; Vyomesh Patel; J Silvio Gutkind
Dysregulated molecular networks in head and neck carcinogenesis.
Oral oncology 2009;45(4-5):324-34.
2009: Rakefet Czerninski; Panomwat Amornphimoltham; Vyomesh Patel; Alfredo A Molinolo; J Silvio Gutkind
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):27-36.
2008: Sebastián Giulianelli; Juan P Cerliani; Caroline A Lamb; Victoria T Fabris; María C Bottino; María A Gorostiaga; Virginia Novaro; Adrián Góngora; Alberto Baldi; Alfredo A Molinolo; Claudia Lanari
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.
International journal of cancer. Journal international du cancer 2008;123(11):2518-31.
2008: Roman Szabo; John P Hobson; Karin List; Alfredo A Molinolo; Chen-Yong Lin; Thomas H Bugge
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.
The Journal of biological chemistry 2008;283(43):29495-504.
2008: Justin Sausville; Alfredo A Molinolo; Xiangfei Cheng; Jon Frampton; Naoko Takebe; J Silvio Gutkind; Ricardo A Feldman
RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(12):3948-55.
2008: Brenda Saikkonen; Tej K Pareek; Nitin Agarwal; Alfredo A Molinolo; MF Kriete; Ashok Kulkarni
Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions.
Cell cycle (Georgetown, Tex.) 2008;7(6):750-3.
2008: Vyomesh Patel; Brian L Hood; Alfredo A Molinolo; Norman H Lee; Thomas P Conrads; John C Braisted; David B Krizman; Timothy D Veenstra; J Silvio Gutkind
Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):1002-14.
2008: Shihui Liu; Hailun Wang; Brooke M Currie; Alfredo A Molinolo; Howard J Leung; Mahtab Moayeri; John Basile; Randall W Alfano; J Silvio Gutkind; Arthur E Frankel; Thomas H Bugge; Stephen H Leppla
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature.
The Journal of biological chemistry 2008;283(1):529-40.
2007: Karin List; Brooke Currie; Tiffany C Scharschmidt; Roman Szabo; Jessica Shireman; Alfredo A Molinolo; Benjamin F Cravatt; Julia A Segre; Thomas H Bugge
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.
The Journal of biological chemistry 2007;282(50):36714-23.
2007: Karin List; John P Hobson; Alfredo A Molinolo; Thomas H Bugge
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
Journal of cellular physiology 2007;213(1):237-45.
2007: Alfredo A Molinolo; Stephen M Hewitt; Panomwat Amornphimoltham; Somboon Keelawat; Samreung Rangdaeng; Abelardo Meneses-García; Ana R Raimondi; Rafael Jufe; María Itoiz; Yan Gao; Dhananjaya Saranath; George S Kaleebi; George H Yoo; Lee Leak; Ernest M Myers; Satoru Shintani; David Wong; H Davis Massey; W Andrew Yeudall; Fulvio Lonardo; John F Ensley; J Silvio Gutkind
Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):4964-73.
2007: Rogerio M Castilho; Cristiane Helena Squarize; Vyomesh Patel; S E Millar; Yi Zheng; Alfredo A Molinolo; J Silvio Gutkind
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells.
Oncogene 2007;26(35):5078-85.
2007: Yasuyuki Honjo; Yansong Bian; Koji Kawakami; Alfredo A Molinolo; Glenn Longenecker; Ramanamurthy Boppana; Jonas Larsson; Stefan Karlsson; J Silvio Gutkind; Raj K Puri; Ashok Kulkarni
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma.
Cell cycle (Georgetown, Tex.) 2007;6(11):1360-6.
2007: Seshagiri R Nandula; Shoba Amarnath; Alfredo A Molinolo; Bidhan Bandyopadhyay; Bradford Hall; Corinne M Goldsmith; Changyu Zheng; Jonas Larsson; Taduru Sreenath; WanJun Chen; Indu S Ambudkar; Stefan Karlsson; Bruce J Baum; Ashok Kulkarni
Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands.
Arthritis and rheumatism 2007;56(6):1798-805.
2007: Jay Sulek; Rebecca Wagenaar-Miller; Jessica Shireman; Alfredo A Molinolo; Daniel H Madsen; Lars H Engelholm; Niels Behrendt; Thomas H Bugge
Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(4):347-53.
2007: Roman Szabo; Alfredo A Molinolo; Karin List; Thomas H Bugge
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development.
Oncogene 2007;26(11):1546-56.
2007: Guadalupe Montero Girard; Silvia I Vanzulli; Juan Pablo Cerliani; María Cecilia Bottino; Julieta Bolado; Jorge Vela; Damasia Becu-Villalobos; Fernando Benavides; J Silvio Gutkind; Vyomesh Patel; Alfredo A Molinolo; Claudia Lanari
Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment.
Breast cancer research : BCR 2007;9(2):R22.
2006: Akrit S Sodhi; Risa Chaisuparat; Jiadi Hu; Amanda K Ramsdell; Brendan D Manning; Edward A Sausville; Earl T Sawai; Alfredo A Molinolo; J Silvio Gutkind; Silvia Montaner
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
Cancer cell 2006;10(2):133-43.
2006: Indira Benakanakere; Cynthia Besch-Williford; Jennifer Schnell; Sandra Brandt; Mark R Ellersieck; Alfredo A Molinolo; Salman M Hyder
Natural and synthetic progestins accelerate 7,12-dimethylbenz[a]anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(13):4062-71.
2006: Ana R Raimondi; Lynn Vitale-cross; Panomwat Amornphimoltham; J Silvio Gutkind; Alfredo A Molinolo
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter.
The American journal of pathology 2006;168(5):1654-65.
2006: Karin List; Roman Szabo; Alfredo A Molinolo; Boye Nielsen; Thomas H Bugge
Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis.
The American journal of pathology 2006;168(5):1513-25.
2006: Ana R Raimondi; Alfredo A Molinolo; Maria E Itoiz
Fibroblast growth factor-2 expression during experimental oral carcinogenesis. Its possible role in the induction of pre-malignant fibrosis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2006;35(4):212-7.
2006: Masako Miura; Yasuo Miura; Hesed Padilla-Nash; Alfredo A Molinolo; BAOJIN FU; Vyomesh Patel; Byoung-Moo Seo; Wataru Sonoyama; Jenny J Zheng; Carl C Baker; Wanjun Chen; Thomas Ried; Songtao Shi
Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.
Stem cells (Dayton, Ohio) 2006;24(4):1095-103.
2006: Robert Cardiff; Miriam R Anver; Gregory P Boivin; Marcus W Bosenberg; Robert R Maronpot; Alfredo A Molinolo; Alexander Nikitin; Jerold E Rehg; George V Thomas; Robert G Russell; Jerrold M Ward
Precancer in mice: animal models used to understand, prevent, and treat human precancers.
Toxicologic pathology 2006;34(6):699-707.
2006: Marina Simian; Alfredo A Molinolo; Claudia Lanari
Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression.
The American journal of pathology 2006;168(1):270-9.
2005: Panomwat Amornphimoltham; Vyomesh Patel; Akrit S Sodhi; Nikolaos G Nikitakis; John J Sauk; Edward A Sausville; Alfredo A Molinolo; J Silvio Gutkind
Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
Cancer research 2005;65(21):9953-61.
2005: Karin List; Roman Szabo; Alfredo A Molinolo; Virote Sriuranpong; Vivien Redeye; Tricia Murdock; Beth Burke; Boye Nielsen; J Silvio Gutkind; Thomas H Bugge
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
Genes & development 2005;19(16):1934-50.
2005: Alejandro Curino; Lars H Engelholm; Susan S Yamada; Kenn Holmbeck; Leif R Lund; Alfredo A Molinolo; Niels Behrendt; Boye Nielsen; Thomas H Bugge
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.
The Journal of cell biology 2005;169(6):977-85.
2005: Cecilia J Proietti; Mariana Salatino; Cinthia Rosemblit; Romina Carnevale; Adali Pecci; Alberto R Kornblihtt; Alfredo A Molinolo; Isabel Frahm; Eduardo H Charreau; Roxana Schillaci; Patricia V Elizalde
Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
Molecular and cellular biology 2005;25(12):4826-40.
2005: Shihui Liu; Vivien Redeye; Jeffrey G Kuremsky; Marissa Kuhnen; Alfredo A Molinolo; Thomas H Bugge; Stephen H Leppla
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin.
Nature biotechnology 2005;23(6):725-30.
2005: Silvia I Vanzulli; Rocío Soldati; Roberto Meiss; Lucas Colombo; Alfredo A Molinolo; Claudia Lanari
Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression.
Carcinogenesis 2005;26(6):1055-63.
2005: Caroline A Lamb; Victoria Fabris; María Alicia Gorostiaga; Luisa Helguero; Alejo Efeyan; María Cecilia Bottino; Marina Simian; Rocío Soldati; Norberto Sanjuan; Alfredo A Molinolo; Claudia Lanari
Isolation of a stromal cell line from an early passage of a mouse mammary tumor line: a model for stromal parenchymal interactions.
Journal of cellular physiology 2005;202(3):672-82.
2005: Haven Baker; Vyomesh Patel; Alfredo A Molinolo; Edward J Shillitoe; John F Ensley; George H Yoo; Abelardo Meneses-García; Jeffrey N Myers; Adel K El-Naggar; J Silvio Gutkind; William S Hancock
Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.
Oral oncology 2005;41(2):183-99.
2005: Caroline A Lamb; Luisa Helguero; Sebastián Giulianelli; Rocío Soldati; Silvia I Vanzulli; Alfredo A Molinolo; Claudia Lanari
Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice.
Breast cancer research : BCR 2005;7(6):R1111-21.
2004: Lynn Vitale-cross; Panomwat Amornphimoltham; Galen Fisher; Alfredo A Molinolo; J Silvio Gutkind
Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.
Cancer research 2004;64(24):8804-7.
2004: Alejandro Curino; Vyomesh Patel; Boye Nielsen; Andrew Iskander; John F Ensley; George H Yoo; F Christopher Holsinger; Jeffrey N Myers; Adel El-Nagaar; Robert M Kellman; Edward J Shillitoe; Alfredo A Molinolo; J Silvio Gutkind; Thomas H Bugge
Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography.
Oral oncology 2004;40(10):1026-32.
2004: Virote Sriuranpong; Apiwat Mutirangura; John W Gillespie; Vyomesh Patel; Panomwat Amornphimoltham; Alfredo A Molinolo; Veerachai Kerekhanjanarong; Siripornchai Supanakorn; Pakpoom Supiyaphun; Samreung Rangdaeng; Narin Voravud; J Silvio Gutkind
Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):4944-58.
2004: Mariana Salatino; Roxana Schillaci; Cecilia J Proietti; Romina Carnevale; Isabel Frahm; Alfredo A Molinolo; Adolfo Iribarren; Eduardo H Charreau; Patricia V Elizalde
Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity.
Oncogene 2004;23(30):5161-74.
2004: Panomwat Amornphimoltham; Virote Sriuranpong; Vyomesh Patel; Fernando Benavides; Claudio J Conti; John J Sauk; Edward A Sausville; Alfredo A Molinolo; J Silvio Gutkind
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):4029-37.
2004: Alejo Efeyan; Victoria Fabris; Susana Merani; Claudia Lanari; Alfredo A Molinolo
Establishment of two hormone-responsive mouse mammary carcinoma cell lines derived from a metastatic mammary tumor.
Breast cancer research and treatment 2004;83(3):233-44.
2003: Luisa Helguero; Marcelo Viegas; Aroumougame Asaithamby; Gopalan Shyamala; Claudia Lanari; Alfredo A Molinolo
Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment.
Breast cancer research and treatment 2003;79(3):379-90.
2003: Caroline A Lamb; Luisa Helguero; Victoria Fabris; Colombo Lucas; Alfredo A Molinolo; Claudia Lanari
Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma.
Breast cancer research and treatment 2003;79(1):25-35.
2003: Luisa Helguero; Caroline Lamb; Alfredo A Molinolo; Claudia Lanari
Evidence for two progesterone receptor binding sites in murine mammary carcinomas.
The Journal of steroid biochemistry and molecular biology 2003;84(1):9-14.
2003: Silvia Montaner; Akrit S Sodhi; Alfredo A Molinolo; Thomas H Bugge; Earl T Sawai; Yunsheng He; Yi Li; Patricio E Ray; J Silvio Gutkind
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes.
Cancer cell 2003;3(1):23-36.
2002: Silvia I Vanzulli; Alejo Efeyan; Fernando Benavides; Luisa Helguero; Giselle Peters; Jianjun Shen; Claudio J Conti; Claudia Lanari; Alfredo A Molinolo
p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas.
Carcinogenesis 2002;23(5):749-58.
2002: Claudia Lanari; Alfredo A Molinolo
Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer.
Breast cancer research : BCR 2002;4(6):240-3.
2001: Mónica Vermeulen; Patricia Pazos; Claudia Lanari; Alfredo A Molinolo; Romina Gamberale; Jorge Geffner; M Giordano
Medroxyprogesterone acetate enhances in vivo and in vitro antibody production.
Immunology 2001;104(1):80-6.
2001: Patricia Pazos; Claudia Lanari; Alfredo A Molinolo
Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice.
Leukemia research 2001;25(2):165-7.
2001: Claudia Lanari; I Lüthy; Caroline A Lamb; Victoria Fabris; Eleonora Pagano; Luisa Helguero; N Sanjuan; Susana Merani; Alfredo A Molinolo
Five novel hormone-responsive cell lines derived from murine mammary ductal carcinomas: in vivo and in vitro effects of estrogens and progestins.
Cancer research 2001;61(1):293-302.
1999: Caroline Lamb; Marina Simian; Alfredo A Molinolo; Patricia Pazos; Claudia Lanari
Regulation of cell growth of a progestin-dependent murine mammary carcinoma in vitro: progesterone receptor involvement in serum or growth factor-induced cell proliferation.
The Journal of steroid biochemistry and molecular biology 1999;70(4-6):133-42.
1999: MF Montecchia; Alfredo A Molinolo; Claudia Lanari
Reversal of estrogen-resistance in murine mammary adenocarcinomas.
Breast cancer research and treatment 1999;54(2):93-9.
1999: MF Montecchia; Caroline Lamb; Alfredo A Molinolo; IA Luthy; Patricia Pazos; Eduardo H Charreau; Silvia I Vanzulli; Claudia Lanari
Progesterone receptor involvement in independent tumor growth in MPA-induced murine mammary adenocarcinomas.
The Journal of steroid biochemistry and molecular biology 1999;68(1-2):11-21.
1998: Patricia V Elizalde; Claudia Lanari; Alfredo A Molinolo; F K Guerra; Maria Balañá; Marina Simian; A M Iribarren; Eduardo H Charreau
Involvement of insulin-like growth factors-I and -II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas.
The Journal of steroid biochemistry and molecular biology 1998;67(4):305-17.
1998: Alfredo A Molinolo; Marina Simian; Silvia I Vanzulli; Patricia Pazos; Caroline Lamb; F Montecchia; Claudia Lanari
Involvement of EGF in medroxyprogesterone acetate (MPA)-induced mammary gland hyperplasia and its role in MPA-induced mammary tumors in BALB/c mice.
Cancer letters 1998;126(1):49-57.
1998: Patricia Pazos; Claudia Lanari; Patricia V Elizalde; F Montecchia; Eduardo H Charreau; Alfredo A Molinolo
Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice.
Carcinogenesis 1998;19(3):529-31.
1997: Claudia Lanari; MF Montecchia; Patricia Pazos; Marina Simian; Silvia I Vanzulli; Caroline Lamb; Alfredo A Molinolo
[Progestin-induced mammary adenocarcinomas in BALB/c mice. Progression from hormone-dependent to autonomous tumors].
Medicina 1997;57 Suppl 2():55-69.
1995: G Dran; I A Luthy; Alfredo A Molinolo; F Montecchia; Eduardo H Charreau; C D Pasqualini; Claudia Lanari
Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma.
Breast cancer research and treatment 1995;35(2):173-86.
1994: E C Kordon; F Guerra; Alfredo A Molinolo; Patricia V Elizalde; Eduardo H Charreau; C D Pasqualini; F Montecchia; Patricia Pazos; G Dran; Claudia Lanari
Effect of sialoadenectomy on medroxyprogesterone-acetate-induced mammary carcinogenesis in BALB/c mice. Correlation between histology and epidermal-growth-factor receptor content.
International journal of cancer. Journal international du cancer 1994;59(2):196-203.
1993: E C Kordon; Alfredo A Molinolo; C D Pasqualini; Eduardo H Charreau; Patricia Pazos; G Dran; Claudia Lanari
Progesterone induction of mammary carcinomas in BALB/c female mice. Correlation between progestin dependence and morphology.
Breast cancer research and treatment 1993;28(1):29-39.
1993: Claudia Lanari; Alfredo A Molinolo; C D Pasqualini
Re: Oral contraceptives and breast cancer.
Journal of the National Cancer Institute 1993;85(18):1525.
1993: Claudia Lanari; Alfredo A Molinolo; C Dosne Pasqualini
[Progesterone and breast cancer].
Medicina 1993;53(3):276-7.
1991: E Kordon; Claudia Lanari; Alfredo A Molinolo; Patricia V Elizalde; Eduardo H Charreau; C Dosne Pasqualini
Estrogen inhibition of MPA-induced mouse mammary tumor transplants.
International journal of cancer. Journal international du cancer 1991;49(6):900-5.
1990: Claudia Lanari; Alfredo A Molinolo; E Kordon; C D Pasualini; Eduardo H Charreau
Progesterone receptors in estrogen-induced fibromatosis of guinea pigs.
Cancer letters 1990;51(3):235-45.
1989: Claudia Lanari; E Kordon; Alfredo A Molinolo; C D Pasqualini; Eduardo H Charreau
Mammary adenocarcinomas induced by medroxyprogesterone acetate: hormone dependence and EGF receptors of BALB/c in vivo sublines.
International journal of cancer. Journal international du cancer 1989;43(5):845-50.
1987: Alfredo A Molinolo; Claudia Lanari; Eduardo H Charreau; N Sanjuan; C D Pasqualini
Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors.
Journal of the National Cancer Institute 1987;79(6):1341-50.
1986: Claudia Lanari; Alfredo A Molinolo; C D Pasqualini
Induction of mammary adenocarcinomas by medroxyprogesterone acetate in BALB/c female mice.
Cancer letters 1986;33(2):215-23.
1986: Claudia Lanari; Alfredo A Molinolo; C D Pasqualini
Inhibitory effect of medroxyprogesterone acetate on foreign body tumorigenesis in mice.
Journal of the National Cancer Institute 1986;77(1):157-64.