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Jeffery Molkentin

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Millay Douglas P; Goonasekera Sanjeewa A; Sargent Michelle A; Maillet Marjorie; Aronow Bruce J; Molkentin Jeffery D
Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.
Millay Douglas P; Maillet Marjorie; Roche Joseph A; Sargent Michelle A; McNally Elizabeth M; Bloch Robert J; Molkentin Jeffery D
Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy.
Tkatchenko Tatiana V; Moreno-Rodriguez Ricardo A; Conway Simon J; Molkentin Jeffery D; Markwald Roger R; Tkatchenko Andrei V
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.

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All Publications

2009: Millay Douglas P; Goonasekera Sanjeewa A; Sargent Michelle A; Maillet Marjorie; Aronow Bruce J; Molkentin Jeffery D
Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(45):19023-8.
2009: Millay Douglas P; Maillet Marjorie; Roche Joseph A; Sargent Michelle A; McNally Elizabeth M; Bloch Robert J; Molkentin Jeffery D
Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy.
The American journal of pathology 2009;175(5):1817-23.
2009: Tkatchenko Tatiana V; Moreno-Rodriguez Ricardo A; Conway Simon J; Molkentin Jeffery D; Markwald Roger R; Tkatchenko Andrei V
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
Physiological genomics 2009;39(3):160-8.
2009: Gelpi Ricardo J; Gao Shumin; Zhai Peiyong; Yan Lin; Hong Chull; Danridge Lauren M A; Ge Hui; Maejima Yasahiro; Donato Martin; Yokota Mitsuhiro; Molkentin Jeffery D; Vatner Dorothy E; Vatner Stephen F; Sadoshima Junichi
Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.
American journal of physiology. Heart and circulatory physiology 2009;297(5):H1814-9.
2009: Maillet Marjorie; Lynch Jeffrey M; Sanna Bastiano; York Allen J; Zheng Yi; Molkentin Jeffery D
Cdc42 is an antihypertrophic molecular switch in the mouse heart.
The Journal of clinical investigation 2009;119(10):3079-88.
2009: Sengupta Arunima; Molkentin Jeffery D; Yutzey Katherine E
FoxO transcription factors promote autophagy in cardiomyocytes.
The Journal of biological chemistry 2009;284(41):28319-31.
2009: MacDonnell Scott M; Weisser-Thomas Jutta; Kubo Hajime; Hanscome Marie; Liu Qinghang; Jaleel Naser; Berretta Remus; Chen Xiongwen; Brown Joan H; Sabri Abdel-Karim; Molkentin Jeffery D; Houser Steven R
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.
Circulation research 2009;105(4):316-25.
2009: Andersson Kristin Brevik; Birkeland Jon Arne Kro; Finsen Alexandra Vanessa; Louch William E; Sjaastad Ivar; Wang Yibin; Chen Ju; Molkentin Jeffery D; Chien Kenneth R; Sejersted Ole M; Christensen Geir
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
Journal of molecular and cellular cardiology 2009;47(2):180-7.
2009: Martin Lee J; Gertz Barry; Pan Yan; Price Ann C; Molkentin Jeffery D; Chang Qing
The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice.
Experimental neurology 2009;218(2):333-46.
2009: Liu Qinghang; Chen Xiongwen; Macdonnell Scott M; Kranias Evangelia G; Lorenz John N; Leitges Michael; Houser Steven R; Molkentin Jeffery D
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Circulation research 2009;105(2):194-200.
2009: Baines Christopher P; Molkentin Jeffery D
Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax.
Journal of molecular and cellular cardiology 2009;46(6):969-77.
2009: Ito Kaoru; Akazawa Hiroshi; Tamagawa Masaji; Furukawa Kensuke; Ogawa Wataru; Yasuda Noritaka; Kudo Yoko; Liao Chien-hui; Yamamoto Rie; Sato Toshiaki; Molkentin Jeffery D; Kasuga Masato; Noda Tetsuo; Nakaya Haruaki; Komuro Issei
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8689-94.
2009: Wu Xu; Chang Baojun; Blair N Scott; Sargent Michelle; York Allen J; Robbins Jeffrey; Shull Gary E; Molkentin Jeffery D
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.
The Journal of clinical investigation 2009;119(4):976-85.
2009: Sadayappan Sakthivel; Gulick James; Klevitsky Raisa; Lorenz John N; Sargent Michelle; Molkentin Jeffery D; Robbins Jeffrey
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.
Circulation 2009;119(9):1253-62.
2009: Carneiro Leticia A M; Travassos Leonardo H; Soares Fraser; Tattoli Ivan; Magalhaes Joao G; Bozza Marcelo T; Plotkowski Maria C; Sansonetti Philippe J; Molkentin Jeffery D; Philpott Dana J; Girardin Stephen E
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells.
Cell host & microbe 2009;5(2):123-36.
2009: Konopatskaya Olga; Gilio Karen; Harper Matthew T; Zhao Yan; Cosemans Judith M E M; Karim Zubair A; Whiteheart Sidney W; Molkentin Jeffery D; Verkade Paul; Watson Steve P; Heemskerk Johan W M; Poole Alastair W
PKCalpha regulates platelet granule secretion and thrombus formation in mice.
The Journal of clinical investigation 2009;119(2):399-407.
2009: Liu Qinghang; Busby Jennifer Caldwell; Molkentin Jeffery D
Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.
Nature cell biology 2009;11(2):154-61.
2009: Hsu Steven; Nagayama Takahiro; Koitabashi Norimichi; Zhang Manling; Zhou Liye; Bedja Djahida; Gabrielson Kathleen L; Molkentin Jeffery D; Kass David A; Takimoto Eiki
Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.
Cardiovascular research 2009;81(2):301-9.
2009: Molkentin Jeffery D; Robbins Jeffrey
With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure.
Journal of molecular and cellular cardiology 2009;46(2):130-6.
2009: Yang Yong Jun; Chen Wei; Edgar Alexander; Li Bo; Molkentin Jeffery D; Berman Jason N; Lin Tong-Jun
Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function.
The Journal of experimental medicine 2009;206(1):195-207.
2009: Donaldson Cameron; Eder Sarah; Baker Corey; Aronovitz Mark J; Weiss Alexandra Dabreo; Hall-Porter Monica; Wang Feng; Ackerman Adam; Karas Richard H; Molkentin Jeffery D; Patten Richard D
Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.
Circulation research 2009;104(2):265-75, 11p following 275.
2009: Diwan Abhinav; Matkovich Scot J; Yuan Qunying; Zhao Wen; Yatani Atsuko; Brown Joan Heller; Molkentin Jeffery D; Kranias Evangelia G; Dorn Gerald W
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death.
The Journal of clinical investigation 2009;119(1):203-12.
2009: Lorts Angela; Schwanekamp Jennifer A; Elrod John W; Sargent Michelle A; Molkentin Jeffery D
Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair.
Circulation research 2009;104(1):e1-7.
2008: Conway Simon J; Molkentin Jeffery D
Periostin as a heterofunctional regulator of cardiac development and disease.
Current genomics 2008;9(8):548-55.
2008: Krenz Maike; Gulick James; Osinska Hanna E; Colbert Melissa C; Molkentin Jeffery D; Robbins Jeffrey
Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18930-5.
2008: Jaleel Naser; Nakayama Hiroyuki; Chen Xiongwen; Kubo Hajime; MacDonnell Scott; Zhang Hongyu; Berretta Remus; Robbins Jeffrey; Cribbs Leanne; Molkentin Jeffery D; Houser Steven R
Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.
Circulation research 2008;103(10):1109-19.
2008: Maillet Marjorie; Purcell Nicole H; Sargent Michelle A; York Allen J; Bueno Orlando F; Molkentin Jeffery D
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility.
The Journal of biological chemistry 2008;283(45):31246-55.
2008: Nieves-Cintrón Madeline; Amberg Gregory C; Navedo Manuel F; Molkentin Jeffery D; Santana Luis F
The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15623-8.
2008: da Costa Martins Paula A; Bourajjaj Meriem; Gladka Monika; Kortland Mara; van Oort Ralph J; Pinto Yigal M; Molkentin Jeffery D; De Windt Leon J
Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling.
Circulation 2008;118(15):1567-76.
2008: Du Heng; Guo Lan; Fang Fang; Chen Doris; Sosunov Alexander A; McKhann Guy M; Yan Yilin; Wang Chunyu; Zhang Hong; Molkentin Jeffery D; Gunn-Moore Frank J; Vonsattel Jean Paul; Arancio Ottavio; Chen John Xi; Yan Shi Du
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Nature medicine 2008;14(10):1097-105.
2008: Fuller Stephen J; Pikkarainen Sampsa; Tham El Li; Cullingford Timothy E; Molkentin Jeffery D; Cornils Hauke; Hergovich Alexander; Hemmings Brian A; Clerk Angela; Sugden Peter H
Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.
Cellular signalling 2008;20(8):1564-77.
2008: Ago Tetsuro; Liu Tong; Zhai Peiyong; Chen Wei; Li Hong; Molkentin Jeffery D; Vatner Stephen F; Sadoshima Junichi
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.
Cell 2008;133(6):978-93.
2008: Millay Douglas P; Sargent Michelle A; Osinska Hanna; Baines Christopher P; Barton Elisabeth R; Vuagniaux Grégoire; Sweeney H Lee; Robbins Jeffrey; Molkentin Jeffery D
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.
Nature medicine 2008;14(4):442-7.
2008: Snider Paige; Hinton Robert B; Moreno-Rodriguez Ricardo A; Wang Jian; Rogers Rhonda; Lindsley Andrew; Li Fang; Ingram David A; Menick Donald; Field Loren; Firulli Anthony B; Molkentin Jeffery D; Markwald Roger; Conway Simon J
Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.
Circulation research 2008;102(7):752-60.
2008: Pinz Ilka; Ostroy Sanford E; Hoyer Kirsten; Osinska Hanna; Robbins Jeffrey; Molkentin Jeffery D; Ingwall Joanne S
Calcineurin-induced energy wasting in a transgenic mouse model of heart failure.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1459-66.
2008: Sahin Bogachan; Hawasli Ammar H; Greene Robert W; Molkentin Jeffery D; Bibb James A
Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C.
European journal of pharmacology 2008;581(3):270-5.
2008: Jobe Shawn M; Wilson Katina M; Leo Lorie; Raimondi Alejandro; Molkentin Jeffery D; Lentz Steven R; Di Paola Jorge
Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis.
Blood 2008;111(3):1257-65.
2008: Manicassamy Santhakumar; Gupta Sonal; Huang Zhaofeng; Molkentin Jeffery D; Shang Weirong; Sun Zuoming
Requirement of calcineurin a beta for the survival of naive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):106-12.
2008: Gurda Grzegorz T; Guo LiLi; Lee Sae-Hong; Molkentin Jeffery D; Williams John A
Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo.
Molecular biology of the cell 2008;19(1):198-206.
2008: Houser Steven R; Molkentin Jeffery D
Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?
Science signaling 2008;1(25):pe31.
2008: Morancho Beatriz; Minguillón Jordi; Molkentin Jeffery D; López-Rodríguez Cristina; Aramburu Jose
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.
BMC molecular biology 2008;9():13.
2007: Hambleton Michael; York Allen; Sargent Michelle A; Kaiser Robert A; Lorenz John N; Robbins Jeffrey; Molkentin Jeffery D
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3768-71.
2007: Heineke Joerg; Auger-Messier Mannix; Xu Jian; Oka Toru; Sargent Michelle A; York Allen; Klevitsky Raisa; Vaikunth Sachin; Duncan Stephen A; Aronow Bruce J; Robbins Jeffrey; Crombleholme Timothy M; Molkentin Jeffery D
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.
The Journal of clinical investigation 2007;117(11):3198-210.
2007: Nakayama Hiroyuki; Chen Xiongwen; Baines Christopher P; Klevitsky Raisa; Zhang Xiaoying; Zhang Hongyu; Jaleel Naser; Chua Balvin H L; Hewett Timothy E; Robbins Jeffrey; Houser Steven R; Molkentin Jeffery D
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.
The Journal of clinical investigation 2007;117(9):2431-44.
2007: Purcell Nicole H; Wilkins Benjamin J; York Allen; Saba-El-Leil Marc K; Meloche Sylvain; Robbins Jeffrey; Molkentin Jeffery D
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14074-9.
2007: Hsieh Patrick C H; Segers Vincent F M; Davis Michael E; MacGillivray Catherine; Gannon Joseph; Molkentin Jeffery D; Robbins Jeffrey; Lee Richard T
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury.
Nature medicine 2007;13(8):970-4.
2007: Nakamura Tomoki; Colbert Melissa; Krenz Maike; Molkentin Jeffery D; Hahn Harvey S; Dorn Gerald W; Robbins Jeffrey
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
The Journal of clinical investigation 2007;117(8):2123-32.
2007: Oka Toru; Xu Jian; Kaiser Robert A; Melendez Jaime; Hambleton Michael; Sargent Michelle A; Lorts Angela; Brunskill Eric W; Dorn Gerald W; Conway Simon J; Aronow Bruce J; Robbins Jeffrey; Molkentin Jeffery D
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.
Circulation research 2007;101(3):313-21.
2007: Norris Russell A; Damon Brook; Mironov Vladimir; Kasyanov Vladimir; Ramamurthi Anand; Moreno-Rodriguez Ricardo; Trusk Thomas; Potts Jay D; Goodwin Richard L; Davis Jeff; Hoffman Stanley; Wen Xuejun; Sugi Yukiko; Kern Christine B; Mjaatvedt Corey H; Turner Debi K; Oka Toru; Conway Simon J; Molkentin Jeffery D; Forgacs Gabor; Markwald Roger R
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues.
Journal of cellular biochemistry 2007;101(3):695-711.
2007: Baines Christopher P; Kaiser Robert A; Sheiko Tatiana; Craigen William J; Molkentin Jeffery D
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.
Nature cell biology 2007;9(5):550-5.
2007: Diwan Abhinav; Koesters Andrew G; Odley Amy M; Pushkaran Suvarnamala; Baines Christopher P; Spike Benjamin T; Daria Diedre; Jegga Anil G; Geiger Hartmut; Aronow Bruce J; Molkentin Jeffery D; Macleod Kay F; Kalfa Theodosia A; Dorn Gerald W
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6794-9.
2007: Sano Masanori; Minamino Tohru; Toko Haruhiro; Miyauchi Hideyuki; Orimo Masayuki; Qin Yingjie; Akazawa Hiroshi; Tateno Kaoru; Kayama Yosuke; Harada Mutsuo; Shimizu Ippei; Asahara Takayuki; Hamada Hirofumi; Tomita Shuhei; Molkentin Jeffrey D; Zou Yunzeng; Komuro Issei
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.
Nature 2007;446(7134):444-8.
2007: Parsons Stephanie A; Millay Douglas P; Sargent Michelle A; Naya Francisco J; McNally Elizabeth M; Sweeney H Lee; Molkentin Jeffery D
Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy.
The Journal of biological chemistry 2007;282(13):10068-78.
2007: Nilsson Lisa M; Sun Zheng-Wu; Nilsson Jenny; Nordström Ina; Chen Yung-Wu; Molkentin Jeffery D; Wide-Swensson Dag; Hellstrand Per; Lydrup Marie-Louise; Gomez Maria F
Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation.
American journal of physiology. Cell physiology 2007;292(3):C1167-78.
2007: Peng Jun; Raddatz Katy; Molkentin Jeffery D; Wu Yiming; Labeit Siegfried; Granzier Henk; Gotthardt Michael
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Circulation 2007;115(6):743-51.
2007: Oka Toru; Xu Jian; Molkentin Jeffery D
Re-employment of developmental transcription factors in adult heart disease.
Seminars in cell & developmental biology 2007;18(1):117-31.
2007: Amberg Gregory C; Navedo Manuel F; Nieves-Cintrón Madeline; Molkentin Jeffery D; Santana Luis F
Calcium sparklets regulate local and global calcium in murine arterial smooth muscle.
The Journal of physiology 2007;579(Pt 1):187-201.
2007: Nieves-Cintrón Madeline; Amberg Gregory C; Nichols C Blake; Molkentin Jeffery D; Santana Luis F
Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension.
The Journal of biological chemistry 2007;282(5):3231-40.
2007: Xiong Dingding; Yajima Toshitaka; Lim Byung-Kwan; Stenbit Antine; Dublin Andrew; Dalton Nancy D; Summers-Torres Daphne; Molkentin Jeffery D; Duplain Herve; Wessely Rainer; Chen Ju; Knowlton Kirk U
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy.
Circulation 2007;115(1):94-102.
2006: Gong Nanling; Bodi Ilona; Zobel Carsten; Schwartz Arnold; Molkentin Jeffery D; Backx Peter H
Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits.
The Journal of biological chemistry 2006;281(50):38498-506.
2006: Sadayappan Sakthivel; Osinska Hanna; Klevitsky Raisa; Lorenz John N; Sargent Michelle; Molkentin Jeffrey D; Seidman Christine E; Seidman Jonathan G; Robbins Jeffrey
Cardiac myosin binding protein C phosphorylation is cardioprotective.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16918-23.
2006: Noh Hye-Lim; Okajima Kazue; Molkentin Jeffery D; Homma Shunichi; Goldberg Ira J
Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction.
American journal of physiology. Endocrinology and metabolism 2006;291(4):E755-60.
2006: Obasanjo-Blackshire Kofo; Mesquita Rui; Jabr Rita I; Molkentin Jeffery D; Hart Stephen L; Marber Michael S; Xia Yang; Heads Richard J
Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase.
Cardiovascular research 2006;71(4):672-83.
2006: Heineke Joerg; Molkentin Jeffery D
Regulation of cardiac hypertrophy by intracellular signalling pathways.
Nature reviews. Molecular cell biology 2006;7(8):589-600.
2006: Hambleton Michael; Hahn Harvey; Pleger Sven T; Kuhn Matthew C; Klevitsky Raisa; Carr Andrew N; Kimball Thomas F; Hewett Timothy E; Dorn Gerald W; Koch Walter J; Molkentin Jeffery D
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Circulation 2006;114(6):574-82.
2006: Nakayama Hiroyuki; Wilkin Benjamin J; Bodi Ilona; Molkentin Jeffery D
Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1660-70.
2006: Sahin Bogachan; Shu Hongjun; Fernandez Joseph; El-Armouche Ali; Molkentin Jeffery D; Nairn Angus C; Bibb James A
Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.
The Journal of biological chemistry 2006;281(34):24322-35.
2006: Xin Mei; Davis Christopher A; Molkentin Jeffery D; Lien Ching-Ling; Duncan Stephen A; Richardson James A; Olson Eric N
A threshold of GATA4 and GATA6 expression is required for cardiovascular development.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11189-94.
2006: Chen Xin; Shevtsov Sergei P; Hsich Eileen; Cui Lei; Haq Syed; Aronovitz Mark; Kerkelä Risto; Molkentin Jeffery D; Liao Ronglih; Salomon Robert N; Patten Richard; Force Thomas
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.
Molecular and cellular biology 2006;26(12):4462-73.
2006: Parsons Stephanie A; Millay Douglas P; Sargent Michelle A; McNally Elizabeth M; Molkentin Jeffery D
Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy.
The American journal of pathology 2006;168(6):1975-85.
2006: Navedo Manuel F; Amberg Gregory C; Nieves Madeline; Molkentin Jeffery D; Santana Luis F
Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle.
The Journal of general physiology 2006;127(6):611-22.
2006: Liu Qinghang; Wilkins Benjamin J; Lee Yong J; Ichijo Hidenori; Molkentin Jeffery D
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.
Molecular and cellular biology 2006;26(10):3785-97.
2006: Sanna Bastiano; Brandt Eric B; Kaiser Robert A; Pfluger Paul; Witt Sandy A; Kimball Thomas R; van Rooij Eva; De Windt Leon J; Rothenberg Marc E; Tschop Matthias H; Benoit Stephen C; Molkentin Jeffery D
Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7327-32.
2006: Nilsson Jenny; Nilsson Lisa M; Chen Yung-Wu; Molkentin Jeffery D; Erlinge David; Gomez Maria F
High glucose activates nuclear factor of activated T cells in native vascular smooth muscle.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):794-800.
2006: Xu Jian; Gong Nanling L; Bodi Ilona; Aronow Bruce J; Backx Peter H; Molkentin Jeffery D
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice.
The Journal of biological chemistry 2006;281(14):9152-62.
2006: Oka Toru; Maillet Marjorie; Watt Alistair J; Schwartz Robert J; Aronow Bruce J; Duncan Stephen A; Molkentin Jeffery D
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.
Circulation research 2006;98(6):837-45.
2006: Molkentin Jeffery D
Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling.
The Journal of clinical investigation 2006;116(3):623-6.
2006: Zhao Wen; Yuan Qunying; Qian Jiang; Waggoner Jason R; Pathak Anand; Chu Guoxiang; Mitton Bryan; Sun Xiaoyin; Jin Jay; Braz Julian C; Hahn Harvey S; Marreez Yehia; Syed Faisal; Pollesello Piero; Annila Arto; Wang Hong-Sheng; Schultz Jo El J; Molkentin Jeffery D; Liggett Stephen B; Dorn Gerald W; Kranias Evangelia G
The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Circulation 2006;113(7):995-1004.
2006: Xu Jian; Kimball Thomas R; Lorenz John N; Brown David A; Bauskin Asne R; Klevitsky Raisa; Hewett Timothy E; Breit Samuel N; Molkentin Jeffery D
GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.
Circulation research 2006;98(3):342-50.
2006: Kempf Tibor; Eden Matthias; Strelau Jens; Naguib Marian; Willenbockel Christian; Tongers Jörn; Heineke Jörg; Kotlarz Daniel; Xu Jian; Molkentin Jeffery D; Niessen Hans W; Drexler Helmut; Wollert Kai C
The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury.
Circulation research 2006;98(3):351-60.
2005: Molkentin Jeffery D
Locating heart failure.
Nature medicine 2005;11(12):1284-5.
2005: Kaiser Robert A; Lyons Jefferson M; Duffy Jodie Y; Wagner Connie J; McLean Kelly M; O'Neill Timothy P; Pearl Jeffrey M; Molkentin Jeffery D
Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2747-51.
2005: Parlakian Ara; Charvet Claude; Escoubet Brigitte; Mericskay Mathias; Molkentin Jeffery D; Gary-Bobo Guillaume; De Windt Leon J; Ludosky Marie-Aline; Paulin Denise; Daegelen Dominique; Tuil David; Li Zhenlin
Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart.
Circulation 2005;112(19):2930-9.
2005: Dai Yan-Shan; Xu Jian; Molkentin Jeffery D
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.
Molecular and cellular biology 2005;25(22):9936-48.
2005: Li Jifen; Patel Vickas V; Kostetskii Igor; Xiong Yanming; Chu Antony F; Jacobson Jason T; Yu Cindy; Morley Gregory E; Molkentin Jeffery D; Radice Glenn L
Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis.
Circulation research 2005;97(5):474-81.
2005: Kaiser Robert A; Liang Qiangrong; Bueno Orlando; Huang Yuan; Lackey Troy; Klevitsky Raisa; Hewett Timothy E; Molkentin Jeffery D
Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo.
The Journal of biological chemistry 2005;280(38):32602-8.
2005: Oka Toru; Dai Yan-Shan; Molkentin Jeffery D
Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo.
Molecular and cellular biology 2005;25(15):6649-59.
2005: Lynch Jeffrey; Guo Lei; Gelebart Pascal; Chilibeck Kaari; Xu Jian; Molkentin Jeffery D; Agellon Luis B; Michalak Marek
Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade.
The Journal of cell biology 2005;170(1):37-47.
2005: Pope Samuel M; Fulkerson Patricia C; Blanchard Carine; Akei Hiroko Saito; Nikolaidis Nikolaos M; Zimmermann Nives; Molkentin Jeffery D; Rothenberg Marc E
Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation.
The Journal of biological chemistry 2005;280(14):13952-61.
2005: Baines Christopher P; Kaiser Robert A; Purcell Nicole H; Blair N Scott; Osinska Hanna; Hambleton Michael A; Brunskill Eric W; Sayen M Richard; Gottlieb Roberta A; Dorn Gerald W; Robbins Jeffrey; Molkentin Jeffery D
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.
Nature 2005;434(7033):658-62.
2005: Heineke Joerg; Ruetten Hartmut; Willenbockel Christian; Gross Sandra C; Naguib Marian; Schaefer Arnd; Kempf Tibor; Hilfiker-Kleiner Denise; Caroni Pico; Kraft Theresia; Kaiser Robert A; Molkentin Jeffery D; Drexler Helmut; Wollert Kai C
Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1655-60.
2005: Kostetskii Igor; Li Jifen; Xiong Yanming; Zhou Rong; Ferrari Victor A; Patel Vickas V; Molkentin Jeffery D; Radice Glenn L
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure.
Circulation research 2005;96(3):346-54.
2005: Sanna Bastiano; Bueno Orlando F; Dai Yan-Shan; Wilkins Benjamin J; Molkentin Jeffery D
Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.
Molecular and cellular biology 2005;25(3):865-78.
2005: Bell Osnat; Gaberman Elena; Kilav Rachel; Levi Ronen; Cox Keith B; Molkentin Jeffery D; Silver Justin; Naveh-Many Tally
The protein phosphatase calcineurin determines basal parathyroid hormone gene expression.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):516-26.
2005: Baines Christopher P; Molkentin Jeffery D
STRESS signaling pathways that modulate cardiac myocyte apoptosis.
Journal of molecular and cellular cardiology 2005;38(1):47-62.
2005: Nimah Marianne; Zhao Bin; Denenberg Alvin G; Bueno Orlando; Molkentin Jeffery; Wong Hector R; Shanley Thomas P
Contribution of MKP-1 regulation of p38 to endotoxin tolerance.
Shock (Augusta, Ga.) 2005;23(1):80-7.
2005: Zhang Lin; Deng Maoxian; Parthasarathy Ranjani; Wang Lei; Mongan Maureen; Molkentin Jeffery D; Zheng Yi; Xia Ying
MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.
Molecular and cellular biology 2005;25(1):60-5.
2004: Moz Yulia; Levi Ronen; Lavi-Moshayoff Vardit; Cox Keith B; Molkentin Jeffery D; Silver Justin; Naveh-Many Tally
Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport.
Journal of the American Society of Nephrology : JASN 2004;15(12):2972-80.
2004: Matsuura Katsuhisa; Wada Hiroshi; Nagai Toshio; Iijima Yoshihiro; Minamino Tohru; Sano Masanori; Akazawa Hiroshi; Molkentin Jeffery D; Kasanuki Hiroshi; Komuro Issei
Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle.
The Journal of cell biology 2004;167(2):351-63.
2004: Wilkins Benjamin J; Molkentin Jeffery D
Calcium-calcineurin signaling in the regulation of cardiac hypertrophy.
Biochemical and biophysical research communications 2004;322(4):1178-91.
2004: Molkentin Jeffery D
Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs.
Cardiovascular research 2004;63(3):467-75.
2004: Parsons Stephanie A; Millay Douglas P; Wilkins Benjamin J; Bueno Orlando F; Tsika Gretchen L; Neilson Joel R; Liberatore Christine M; Yutzey Katherine E; Crabtree Gerald R; Tsika Richard W; Molkentin Jeffery D
Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.
The Journal of biological chemistry 2004;279(25):26192-200.
2004: Michael Ashour; Haq Syed; Chen Xin; Hsich Eileen; Cui Lei; Walters Brian; Shao Zhili; Bhattacharya Kausik; Kilter Heiko; Huggins Gordon; Andreucci Michele; Periasamy Muthu; Solomon Robert N; Liao Ronglih; Patten Richard; Molkentin Jeffery D; Force Thomas
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
The Journal of biological chemistry 2004;279(20):21383-93.
2004: Lips Daniel J; Bueno Orlando F; Wilkins Benjamin J; Purcell Nicole H; Kaiser Robert A; Lorenz John N; Voisin Laure; Saba-El-Leil Marc K; Meloche Sylvain; Pouysségur Jacques; Pagès Gilles; De Windt Leon J; Doevendans Pieter A; Molkentin Jeffery D
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.
Circulation 2004;109(16):1938-41.
2004: Aliahmad Parinaz; O'Flaherty Emmett; Han Peggy; Goularte Olivia D; Wilkinson Beverley; Satake Masanobu; Molkentin Jeffery D; Kaye Jonathan
TOX provides a link between calcineurin activation and CD8 lineage commitment.
The Journal of experimental medicine 2004;199(8):1089-99.
2004: Kaiser Robert A; Bueno Orlando F; Lips Daniel J; Doevendans Pieter A; Jones Fred; Kimball Thomas F; Molkentin Jeffery D
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.
The Journal of biological chemistry 2004;279(15):15524-30.
2004: Braz Julian C; Gregory Kimberly; Pathak Anand; Zhao Wen; Sahin Bogachan; Klevitsky Raisa; Kimball Thomas F; Lorenz John N; Nairn Angus C; Liggett Stephen B; Bodi Ilona; Wang Su; Schwartz Arnold; Lakatta Edward G; DePaoli-Roach Anna A; Robbins Jeffrey; Hewett Timothy E; Bibb James A; Westfall Margaret V; Kranias Evangelia G; Molkentin Jeffery D
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2004: Lange Alexander W; Molkentin Jeffery D; Yutzey Katherine E
DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice.
Developmental biology 2004;266(2):346-60.
2004: Purcell Nicole H; Darwis Dina; Bueno Orlando F; Müller Judith M; Schüle Roland; Molkentin Jeffery D
Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.
Molecular and cellular biology 2004;24(3):1081-95.
2004: Dorn Gerald W; Molkentin Jeffery D
Manipulating cardiac contractility in heart failure: data from mice and men.
Circulation 2004;109(2):150-8.
2004: Wilkins Benjamin J; Dai Yan-Shan; Bueno Orlando F; Parsons Stephanie A; Xu Jian; Plank David M; Jones Fred; Kimball Thomas R; Molkentin Jeffery D
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.
Circulation research 2004;94(1):110-8.
2004: Bueno Orlando F; Lips Daniel J; Kaiser Robert A; Wilkins Benjamin J; Dai Yan-Shan; Glascock Betty J; Klevitsky Raisa; Hewett Timothy E; Kimball Thomas R; Aronow Bruce J; Doevendans Pieter A; Molkentin Jeffery D
Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction.
Circulation research 2004;94(1):91-9.
2003: Liang Qiangrong; Molkentin Jeffery D
Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models.
Journal of molecular and cellular cardiology 2003;35(12):1385-94.
2003: Liang Qiangrong; Bueno Orlando F; Wilkins Benjamin J; Kuan Chia-Yi; Xia Ying; Molkentin Jeffery D
c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.
The EMBO journal 2003;22(19):5079-89.
2003: Prabhakar Rethinasamy; Petrashevskaya Natalia; Schwartz Arnold; Aronow Bruce; Boivin Greg P; Molkentin Jeffery D; Wieczorek David F
A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation.
Molecular and cellular biochemistry 2003;251(1-2):33-42.
2003: Purcell Nicole H; Molkentin Jeffery D
Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?
Circulation 2003;108(6):638-40.
2003: Haq Syed; Kilter Heiko; Michael Ashour; Tao Jingzang; O'Leary Eileen; Sun Xio Ming; Walters Brian; Bhattacharya Kausik; Chen Xin; Cui Lei; Andreucci Michele; Rosenzweig Anthony; Guerrero J Luis; Patten Richard; Liao Ronglih; Molkentin Jeffery; Picard Michael; Bonventre Joseph V; Force Thomas
Deletion of cytosolic phospholipase A2 promotes striated muscle growth.
Nature medicine 2003;9(7):944-51.
2003: Schubert William; Yang Xiao Yong; Yang Teddy T C; Factor Stephen M; Lisanti Michael P; Molkentin Jeffery D; Rincon Mercedes; Chow Chi-Wing
Requirement of transcription factor NFAT in developing atrial myocardium.
The Journal of cell biology 2003;161(5):861-74.
2003: Parsons Stephanie A; Wilkins Benjamin J; Bueno Orlando F; Molkentin Jeffery D
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.
Molecular and cellular biology 2003;23(12):4331-43.
2003: Bushdid Paul B; Osinska Hanna; Waclaw Ronald R; Molkentin Jeffery D; Yutzey Katherine E
NFATc3 and NFATc4 are required for cardiac development and mitochondrial function.
Circulation research 2003;92(12):1305-13.
2003: Braz Julian C; Bueno Orlando F; Liang Qiangrong; Wilkins Benjamin J; Dai Yan-Shan; Parsons Stephanie; Braunwart Joseph; Glascock Betty J; Klevitsky Raisa; Kimball Thomas F; Hewett Timothy E; Molkentin Jeffery D
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling.
The Journal of clinical investigation 2003;111(10):1475-86.
2003: Molkentin Jeffery D
A friend within the heart: natriuretic peptide receptor signaling.
The Journal of clinical investigation 2003;111(9):1275-7.
2003: Suzuki Yuichiro J; Day Regina M; Tan Chia Chi; Sandven Tor H; Liang Qiangrong; Molkentin Jeffery D; Fanburg Barry L
Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells.
The Journal of biological chemistry 2003;278(19):17525-31.
2003: Petrich Brian G; Molkentin Jeffery D; Wang Yibin
Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):749-51.
2003: Rybin Vitalyi O; Sabri Abdelkarim; Short Jacob; Braz Julian C; Molkentin Jeffery D; Steinberg Susan F
Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations.
The Journal of biological chemistry 2003;278(16):14555-64.
2003: Dong Deli; Duan Yanjun; Guo Jiqing; Roach Dan E; Swirp Shauni L; Wang Li; Lees-Miller J P; Sheldon R S; Molkentin Jeffery D; Duff Henry J
Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels.
Cardiovascular research 2003;57(2):320-32.
2003: Gajewski Kathleen; Wang Jianbo; Molkentin Jeffery D; Chen Elizabeth H; Olson Eric N; Schulz Robert A
Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1040-5.
2003: Sayen M R; Gustafsson Asa B; Sussman Mark A; Molkentin Jeffery D; Gottlieb Roberta A
Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production.
American journal of physiology. Cell physiology 2003;284(2):C562-70.
2003: Semeniuk L M; Severson D L; Kryski A J; Swirp S L; Molkentin J D; Duff H J
Time-dependent systolic and diastolic function in mice overexpressing calcineurin.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H425-30.
2002: van Rooij Eva; Doevendans Pieter A; de Theije Chiel C; Babiker Fawzi A; Molkentin Jeffery D; de Windt Leon J
Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy.
The Journal of biological chemistry 2002;277(50):48617-26.
2002: Bueno Orlando F; Molkentin Jeffery D
Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death.
Circulation research 2002;91(9):776-81.
2002: Wilkins Benjamin J; De Windt Leon J; Bueno Orlando F; Braz Julian C; Glascock Betty J; Kimball Thomas F; Molkentin Jeffery D
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.
Molecular and cellular biology 2002;22(21):7603-13.
2002: Tomita Masuhiro; Reinhold Martina I; Molkentin Jeffery D; Naski Michael C
Calcineurin and NFAT4 induce chondrogenesis.
The Journal of biological chemistry 2002;277(44):42214-8.
2002: Lynch Roy A; Wagoner Lynne; Li Shunan; Sparks Li; Molkentin Jeffery; Dorn Gerald W
Novel and nondetected human signaling protein polymorphisms.
Physiological genomics 2002;10(3):159-68.
2002: Jacob Asha; Molkentin Jeffery D; Smolenski Albert; Lohmann Suzanne M; Begum Najma
Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs.
American journal of physiology. Cell physiology 2002;283(3):C704-13.
2002: Fiedler Beate; Lohmann Suzanne M; Smolenski Albert; Linnemuller Stephan; Pieske Burkert; Schroder Frank; Molkentin Jeffery D; Drexler Helmut; Wollert Kai C
Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11363-8.
2002: Bueno Orlando F; Brandt Eric B; Rothenberg Marc E; Molkentin Jeffery D
Defective T cell development and function in calcineurin A beta -deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9398-403.
2002: Dai Yan-Shan; Cserjesi Peter; Markham Bruce E; Molkentin Jeffery D
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism.
The Journal of biological chemistry 2002;277(27):24390-8.
2002: Donelan Matthew J; Morfini Gerardo; Julyan Richard; Sommers Scott; Hays Lori; Kajio Hiroshi; Briaud Isabelle; Easom Richard A; Molkentin Jeffery D; Brady Scott T; Rhodes Christopher J
Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
The Journal of biological chemistry 2002;277(27):24232-42.
2002: Liang Qiangrong; Molkentin Jeffery D
Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression.
Journal of molecular and cellular cardiology 2002;34(6):611-6.
2002: Wilkins Benjamin J; Molkentin Jeffery D
Calcineurin and cardiac hypertrophy: where have we been? Where are we going?
The Journal of physiology 2002;541(Pt 1):1-8.
2002: Petrashevskaya Natalia N; Bodi Ilona; Rubio Marta; Molkentin Jeffery D; Schwartz Arnold
Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse.
Cardiovascular research 2002;54(1):117-32.
2002: Chu Guoxiang; Carr Andrew N; Young Karen B; Lester J William; Yatani Atsuko; Sanbe Atsushi; Colbert Melissa C; Schwartz Steven M; Frank Konrad F; Lampe Paul D; Robbins Jeffrey; Molkentin Jeffery D; Kranias Evangelia G
Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure.
Cardiovascular research 2002;54(1):105-16.
2002: Sah Rajan; Oudit Gavin Y; Nguyen The-Tin T; Lim Hae W; Wickenden Alan D; Wilson Gregory J; Molkentin Jeffery D; Backx Peter H
Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice.
Circulation 2002;105(15):1850-6.
2002: Bueno Orlando F; Wilkins Benjamin J; Tymitz Kevin M; Glascock Betty J; Kimball Thomas F; Lorenz John N; Molkentin Jeffery D
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4586-91.
2002: Bueno Orlando F; van Rooij Eva; Molkentin Jeffery D; Doevendans Pieter A; De Windt Leon J
Calcineurin and hypertrophic heart disease: novel insights and remaining questions.
Cardiovascular research 2002;53(4):806-21.
2002: Kassiri Zamaneh; Zobel Carsten; Nguyen The-Tin T; Molkentin Jeffery D; Backx Peter H
Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes.
Circulation research 2002;90(5):578-85.
2002: Braz Julian C; Bueno Orlando F; De Windt Leon J; Molkentin Jeffery D
PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2).
The Journal of cell biology 2002;156(5):905-19.
2001: Liang Q; Wiese R J; Bueno O F; Dai Y S; Markham B E; Molkentin J D
The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.
Molecular and cellular biology 2001;21(21):7460-9.
2001: Liang Q; De Windt L J; Witt S A; Kimball T R; Markham B E; Molkentin J D
The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.
The Journal of biological chemistry 2001;276(32):30245-53.
2001: Sohal D S; Nghiem M; Crackower M A; Witt S A; Kimball T R; Tymitz K M; Penninger J M; Molkentin J D
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein.
Circulation research 2001;89(1):20-5.
2001: Lim H W; New L; Han J; Molkentin J D
Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.
The Journal of biological chemistry 2001;276(19):15913-9.
2001: Li J; Molkentin J D; Colbert M C
Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation.
Developmental biology 2001;232(2):351-61.
2001: De Windt L J; Lim H W; Bueno O F; Liang Q; Delling U; Braz J C; Glascock B J; Kimball T F; del Monte F; Hajjar R J; Molkentin J D
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3322-7.
2001: Yatani A; Honda R; Tymitz K M; Lalli M J; Molkentin J D
Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway.
Journal of molecular and cellular cardiology 2001;33(2):249-59.
2001: Haq S; Choukroun G; Lim H; Tymitz K M; del Monte F; Gwathmey J; Grazette L; Michael A; Hajjar R; Force T; Molkentin J D
Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure.
Circulation 2001;103(5):670-7.
2001: Bueno O F; De Windt L J; Lim H W; Tymitz K M; Witt S A; Kimball T R; Molkentin J D
The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo.
Circulation research 2001;88(1):88-96.
2000: Bueno O F; De Windt L J; Tymitz K M; Witt S A; Kimball T R; Klevitsky R; Hewett T E; Jones S P; Lefer D J; Peng C F; Kitsis R N; Molkentin J D
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.
The EMBO journal 2000;19(23):6341-50.
2000: Molkentin J D
The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.
The Journal of biological chemistry 2000;275(50):38949-52.
2000: Molkentin J D
Calcineurin and beyond: cardiac hypertrophic signaling.
Circulation research 2000;87(9):731-8.
2000: Haq S; Choukroun G; Kang Z B; Ranu H; Matsui T; Rosenzweig A; Molkentin J D; Alessandrini A; Woodgett J; Hajjar R; Michael A; Force T
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy.
The Journal of cell biology 2000;151(1):117-30.
2000: Delling U; Tureckova J; Lim H W; De Windt L J; Rotwein P; Molkentin J D
A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression.
Molecular and cellular biology 2000;20(17):6600-11.
2000: Molkentin J D; Tymitz K M; Richardson J A; Olson E N
Abnormalities of the genitourinary tract in female mice lacking GATA5.
Molecular and cellular biology 2000;20(14):5256-60.
2000: Lim H W; De Windt L J; Steinberg L; Taigen T; Witt S A; Kimball T R; Molkentin J D
Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy.
Circulation 2000;101(20):2431-7.
2000: De Windt L J; Lim H W; Haq S; Force T; Molkentin J D
Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways.
The Journal of biological chemistry 2000;275(18):13571-9.
2000: Lim H W; De Windt L J; Mante J; Kimball T R; Witt S A; Sussman M A; Molkentin J D
Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.
Journal of molecular and cellular cardiology 2000;32(4):697-709.
2000: Sussman M A; Welch S; Walker A; Klevitsky R; Hewett T E; Witt S A; Kimball T R; Price R; Lim H W; Molkentin J D
Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice.
Cardiovascular research 2000;46(1):90-101.
2000: De Windt L J; Lim H W; Taigen T; Wencker D; Condorelli G; Dorn G W; Kitsis R N; Molkentin J D
Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure.
Circulation research 2000;86(3):255-63.
2000: Taigen T; De Windt L J; Lim H W; Molkentin J D
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1196-201.
2000: Han J; Molkentin J D
Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology.
Trends in cardiovascular medicine 2000;10(1):19-22.
2000: Molkentin J D; Antos C; Mercer B; Taigen T; Miano J M; Olson E N
Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart.
Developmental biology 2000;217(2):301-9.
1999: Sussman M A; Welch S; Gude N; Khoury P R; Daniels S R; Kirkpatrick D; Walsh R A; Price R L; Lim H W; Molkentin J D
Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice.
The American journal of pathology 1999;155(6):2101-13.
1999: Gajewski K; Fossett N; Molkentin J D; Schulz R A
The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila.
Development (Cambridge, England) 1999;126(24):5679-88.
1999: Olson E N; Molkentin J D
Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?
Circulation research 1999;84(6):623-32.
1999: Wilson-Rawls J; Molkentin J D; Black B L; Olson E N
Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C.
Molecular and cellular biology 1999;19(4):2853-62.
1998: Sussman M A; Lim H W; Gude N; Taigen T; Olson E N; Robbins J; Colbert M C; Gualberto A; Wieczorek D F; Molkentin J D
Prevention of cardiac hypertrophy in mice by calcineurin inhibition.
Science (New York, N.Y.) 1998;281(5383):1690-3.
1998: Molkentin J D; Lu J R; Antos C L; Markham B; Richardson J; Robbins J; Grant S R; Olson E N
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
Cell 1998;93(2):215-28.
1998: Katoh Y; Molkentin J D; Dave V; Olson E N; Periasamy M
MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.
The Journal of biological chemistry 1998;273(3):1511-8.
1998: Black B L; Molkentin J D; Olson E N
Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2.
Molecular and cellular biology 1998;18(1):69-77.
1997: Herzig T C; Jobe S M; Aoki H; Molkentin J D; Cowley A W; Izumo S; Markham B E
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7543-8.
1997: Molkentin J D; Lin Q; Duncan S A; Olson E N
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Genes & development 1997;11(8):1061-72.
1996: Molkentin J D; Olson E N
Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9366-73.
1996: Molkentin J D; Olson E N
Defining the regulatory networks for muscle development.
Current opinion in genetics & development 1996;6(4):445-53.
1996: Molkentin J D; Firulli A B; Black B L; Martin J F; Hustad C M; Copeland N; Jenkins N; Lyons G; Olson E N
MEF2B is a potent transactivator expressed in early myogenic lineages.
Molecular and cellular biology 1996;16(7):3814-24.
1996: Molkentin J D; Li L; Olson E N
Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.
The Journal of biological chemistry 1996;271(29):17199-204.
1996: Molkentin J D; Black B L; Martin J F; Olson E N
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.
Molecular and cellular biology 1996;16(6):2627-36.
1995: Molkentin J D; Black B L; Martin J F; Olson E N
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins.
Cell 1995;83(7):1125-36.
1995: Ranganayakulu G; Zhao B; Dokidis A; Molkentin J D; Olson E N; Schulz R A
A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila.
Developmental biology 1995;171(1):169-81.

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Jeffery Molkentin

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