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Jeffery Molkentin

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Robert N Correll; Jeffery D Molkentin
CaMKII Does It Again: Even the Mitochondria Cannot Escape Its Influence.
John W Elrod; Jeffery D Molkentin
Physiologic functions of cyclophilin d and the mitochondrial permeability transition pore.
Chad K Nicholson; Junichi Sadoshima; Jonathan P Lambert; Jeffery D Molkentin; John W Calvert
Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.

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All Publications

2013: Robert N Correll; Jeffery D Molkentin
CaMKII Does It Again: Even the Mitochondria Cannot Escape Its Influence.
Circulation research 2013;112(9):1208-11.
2013: John W Elrod; Jeffery D Molkentin
Physiologic functions of cyclophilin d and the mitochondrial permeability transition pore.
Circulation journal : official journal of the Japanese Circulation Society 2013;77(5):1111-22.
2013: Chad K Nicholson; Junichi Sadoshima; Jonathan P Lambert; Jeffery D Molkentin; John W Calvert
Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):744-51.
2013: Hee Yun Suk; Teddy T C Yang; XiaoYong Yang; Raymond Y L Yu; Chen Zhou; Hong Zhu; Deborah Brancho; John W Calvert; Philippe G Frank; Alessandra Ghigo; Emilio Hirsch; Jianping Jin; Ja-Young Kim; David J Lefer; Michael P Lisanti; Jeffery D Molkentin; Opeyemi Olabisi; Philipp E Scherer; Chi-Wing Chow
Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
The Journal of biological chemistry 2013;288(5):3477-88.
2013: Kamaldeen Muili; Abrahim I Orabi; George Perides; Sheharyar Sarwar; Vijay P Singh; Dong Wang; John Williams; Tanveer A Javed; Shunqian Jin; Yuhuan Luo; Syeda M Mahmood; Jeffery D Molkentin; Meena Ananthanaravanan; John F Eisses; Sohail Z Husain
Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.
The Journal of biological chemistry 2013;288(1):570-80.
2013: Mannix Auger-Messier; Orlando F Bueno; Sanjeewa A Goonasekera; John N Lorenz; Jop H van Berlo; Robert N Willette; Federica Accornero; Jeffery D Molkentin
Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.
Circulation research 2013;112(1):48-56.
2013: Jop H van Berlo; Marjorie Maillet; Jeffery D Molkentin
Signaling effectors underlying pathologic growth and remodeling of the heart.
The Journal of clinical investigation 2013;123(1):37-45.
2013: Marjorie Maillet; Jop H van Berlo; Jeffery D Molkentin
Molecular basis of physiological heart growth: fundamental concepts and new players.
Nature reviews. Molecular cell biology 2013;14(1):38-48.
2012: Emily M Schulz; Hajer N Sheikh; R John Solaro; Richard N Correll; Patti L Engel; Marco S Lofrano-Alves; Jeffery D Molkentin; Gilbert Newman; Jo El J Schultz; Beata M Wolska; David F Wieczorek
Tropomyosin dephosphorylation results in compensated cardiac hypertrophy.
The Journal of biological chemistry 2012;287(53):44478-89.
2012: Faye M Drawnel; Chihiro Hisatsune; Ning Liu; Marjorie Maillet; Katsuhiko Mikoshiba; Jeffery D Molkentin; hanneke okkenhaug; Simon R Andrews; Jan Magnus Aronsen; Martin D Bootman; Daniele Catalucci; Ivar Sjaastad; Fredrik Swift; Dagmar Wachten; H Llewelyn Roderick
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.
The Journal of cell biology 2012;199(5):783-98.
2012: Hui Gao; Larry A Barr; Remus M Berretta; Hajime Kubo; Catherine A Makarewich; Jeffery D Molkentin; Fang Wang; Wei Wang; Hongyu Zhang; Steven R Houser
Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling.
Journal of molecular and cellular cardiology 2012;53(5):657-67.
2012: Jason Karch; Jeffery D Molkentin
Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis?
Circulation research 2012;111(10):1258-60.
2012: Yasuhiro Maejima; Jeffery D Molkentin; Junichi Sadoshima; Jonathan Galeotti; Peiyong Zhai
Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload.
American journal of physiology. Heart and circulatory physiology 2012;303(8):H979-88.
2012: Naresh C Bal; Sanjeewa A Goonasekera; Subash C Gupta; Santosh K Maurya; Jeffery D Molkentin; Meghna Pant; Leslie A Rowland; Sanjaya K Sahoo; Sana A Shaikh; Danesh H Sopariwala; Eric Bombardier; A Russell Tupling; Muthu Periasamy
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.
Nature medicine 2012;18(10):1575-9.
2012: Jennifer Davis; Marjorie Maillet; Joseph M Miano; Jeffery D Molkentin
Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research.
Circulation research 2012;111(6):761-77.
2012: Angela Lorts; Elizabeth M McNally; Troy A Baudino; Jennifer A Schwanekamp; Jeffery D Molkentin
Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-β pathway.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(27):10978-83.
2012: Steven R Houser; David A Kass; Walter Koch; Walter J Koch; Kenneth B Margulies; Jeffery D Molkentin; Anne M Murphy; Sumanth D Prabhu; Howard A Rockman; Francis G Spinale; Mark A Sussman; Gary S Francis
Animal models of heart failure: a scientific statement from the American Heart Association.
Circulation research 2012;111(1):131-50.
2012: Jeffrey M Lynch; Kaari A Lynch; Marjorie Maillet; Bruce J Aronow; N Scott Blair; Jack Lawler; John N Lorenz; Kazutoshi Mori; Tetsuya Okada; Hanna Osinska; Ron Prywes; Jeffrey Robbins; Michelle A Sargent; Aryn Schloemer; Davy Vanhoutte; Jeffery D Molkentin
A thrombospondin-dependent pathway for a protective ER stress response.
Cell 2012;149(6):1257-68.
2012: Kamaldeen Muili; Abrahim I Orabi; Ahsan U Shah; Mahwish Ahmad; Syeda M Mahmood; Jeffery D Molkentin; Sohail Z Husain
Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(8):G898-905.
2012: Qinghang Liu; Mannix Auger-Messier; Yi Chen; Jeffery D Molkentin
Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling.
Circulation research 2012;110(8):1077-86.
2012: Catherine A Makarewich; Jeffery D Molkentin; Victor Rizzo; Baohua Yang; Hongyu Zhang; Remus M Berretta; Robert N Correll; Hui Gao; Steven R Houser
A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility.
Circulation research 2012;110(5):669-74.
2012: Sanjeewa A Goonasekera; Jeffery D Molkentin
Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte.
Journal of molecular and cellular cardiology 2012;52(2):317-22.
2012: Craig Bolte; Tanya V Kalin; Jeffery D Molkentin; Jo El J Schultz; Allen York; Yufang Zhang; Vladimir V. Kalinichenko
Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling.
PloS one 2012;7(11):e48713.
2011: Federica Accornero; Jeffery D Molkentin
Placental growth factor as a protective paracrine effector in the heart.
Trends in cardiovascular medicine 2011;21(8):220-4.
2011: Qinghang Liu; Jeffery D Molkentin
Protein kinase Cα as a heart failure therapeutic target.
Journal of molecular and cellular cardiology 2011;51(4):474-8.
2011: Jennifer R Hom; Jeffery D Molkentin; Karen L de Mesy Bentley; David L Hoffman; Rodrigo A Quintanilla; Shey-Shing Sheu; George A Porter
The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation.
Developmental cell 2011;21(3):469-78.
2011: Jop H van Berlo; William T Pu; Bruce J Aronow; John Elrod; Jeffery D Molkentin
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(30):12331-6.
2011: Federica Accornero; Matthew J Benard; Peter Carmeliet; John N Lorenz; Jop H van Berlo; Jeffery D Molkentin
Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism.
Circulation research 2011;109(3):272-80.
2011: Sakthivel Sadayappan; Metin Avkiran; David Barefield; Donald M Bers; Joan Heller Brown; Friederike Cuello; James Gulick; Jeanne James; Valerie M Lasko; John N Lorenz; Marjorie Maillet; Jody L Martin; Jeffery D Molkentin; Hanna Osinska; Jeffrey Robbins
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.
Circulation research 2011;109(2):141-50.
2011: Li Qian; Christopher Semsarian; Deepak Srivastava; Ouarda Taghli-Lamallem; Jeffrey A Towbin; Georg Vogler; David Winlaw; Joshua D Wythe; Yi Zheng; Benoit G Bruneau; Jerome Cartry; Timothy Crawley; Sally Dunwoodie; Diane Fatkin; Richard P Harvey; Yu Huang; Isabelle N King; Jiandong Liu; Marjorie Maillet; Bhagyalaxmi Mohapatra; Jeffery D Molkentin; Karen Ocorr; Robyn T Otway; Rolf Bodmer
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
The Journal of cell biology 2011;193(7):1181-96.
2011: James A Stefater; Bart Williams; MARSHA WILLS-KARP; Terry Yamaguchi; Rieko Ajima; Adam R Burr; April C Carpenter; Jieqing Fan; Napoleone Ferrara; Holger Gerhardt; Ian Lewkowich; Giovanni Mariggi; Jeffery D Molkentin; Jeffrey W Pollard; Sujata Rao; Richard Lang
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.
Nature 2011;474(7352):511-5.
2011: Astrid Breitbart; Mannix Auger-Messier; Jeffery D Molkentin; Jörg Heineke
Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting.
American journal of physiology. Heart and circulatory physiology 2011;300(6):H1973-82.
2011: Naohiro Yamaguchi; Asima Chakraborty; Daniel A Pasek; Jeffery D Molkentin; Gerhard Meissner
Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.
American journal of physiology. Heart and circulatory physiology 2011;300(6):H2187-95.
2011: Marcel Meissner; Petra Weissgerber; Juan E Camacho Londoño; Jean Prenen; Sabine Link; Sandra Ruppenthal; Jeffery D Molkentin; Peter Lipp; Bernd Nilius; Marc Freichel; Veit Flockerzi
Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene.
The Journal of biological chemistry 2011;286(18):15875-82.
2011: Irene L Ch'en; Jennifer S Tsau; Jeffery D Molkentin; Masaaki Komatsu; Stephen M Hedrick
Mechanisms of necroptosis in T cells.
The Journal of experimental medicine 2011;208(4):633-41.
2011: Izhak Kehat; Federica Accornero; Bruce J Aronow; Jeffery D Molkentin
Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.
The Journal of cell biology 2011;193(1):21-9.
2011: Roberto Bolli; Adam B Stein; Yiru Guo; Ou-Li Wang; Gregg Rokosh; Buddhadeb Dawn; Jeffery D Molkentin; Santosh K Sanganalmath; Yanqing Zhu; Yu-Ting Xuan
A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning.
Journal of molecular and cellular cardiology 2011;50(4):589-97.
2011: Arunima Sengupta; Jeffery D Molkentin; Ji-Hye Paik; Ronald A DePinho; Katherine E Yutzey
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.
The Journal of biological chemistry 2011;286(9):7468-78.
2011: Sanjeewa A Goonasekera; Chi K Lam; Douglas P Millay; Michelle A Sargent; Roger J Hajjar; Evangelia G Kranias; Jeffery D Molkentin
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.
The Journal of clinical investigation 2011;121(3):1044-52.
2011: Xiongwen Chen; Hiroyuki Nakayama; Xiaoying Zhang; Xiaojie Ai; David M Harris; Mingxin Tang; Hongyu Zhang; Christopher Szeto; Kathryn Stockbower; Remus M Berretta; Andrea D Eckhart; Walter J Koch; Jeffery D Molkentin; Steven R Houser
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Journal of molecular and cellular cardiology 2011;50(3):460-70.
2011: Natali Froese; Badder Kattih; Astrid Breitbart; Andrea Grund; Robert Geffers; Jeffery D Molkentin; Andreas Kispert; Kai C Wollert; Helmut Drexler; Joerg Heineke
GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling.
The Journal of biological chemistry 2011;286(7):5680-90.
2011: Mortimer Korf-Klingebiel; Tibor Kempf; Klaus-Dieter Schlüter; Christian Willenbockel; Torben Brod; Jörg Heineke; Volker J Schmidt; Franziska Jantzen; Ralf P Brandes; Peter H Sugden; Helmut Drexler; Jeffery D Molkentin; Kai C Wollert
Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.
Circulation 2011;123(5):504-14.
2011: Jeffery D Molkentin
The transcription factor C/EBPbeta serves as a master regulator of physiologic cardiac hypertrophy.
Circulation research 2011;108(3):277-8.
2011: Peter H Sugden; Thomais Markou; Stephen J Fuller; El Li Tham; Jeffery D Molkentin; Hugh F Paterson; Angela Clerk
Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.
Cellular signalling 2011;23(2):468-77.
2011: Ramesh N Reddy; Brian R Roberts; Taylor L Knotts; Jeffery D Molkentin; S Russ Price; Jennifer L Gooch
Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney.
Journal of cellular and molecular medicine 2011;15(2):414-22.
2011: Petra Eder; Jeffery D Molkentin
TRPC channels as effectors of cardiac hypertrophy.
Circulation research 2011;108(2):265-72.
2011: Izhak Kehat; Jennifer Davis; Malte Tiburcy; Federica Accornero; Marc K Saba-El-Leil; Marjorie Maillet; Allen York; John N Lorenz; Wolfram H Zimmermann; Sylvain Meloche; Jeffery D Molkentin
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.
Circulation research 2011;108(2):176-83.
2011: Janaka P Wansapura; Douglas P Millay; R Scott Dunn; Jeffery D Molkentin; D Woodrow Benson
Magnetic resonance imaging assessment of cardiac dysfunction in δ-sarcoglycan null mice.
Neuromuscular disorders : NMD 2011;21(1):68-73.
2010: Izhak Kehat; Jeffery D Molkentin
Molecular pathways underlying cardiac remodeling during pathophysiological stimulation.
Circulation 2010;122(25):2727-35.
2010: Matthew Harper; Jeffery D Molkentin; Alastair W Poole
Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets.
Cell calcium 2010;48(6):333-40.
2010: Mingxin Tang; Jie Li; Wei Huang; Huabo Su; Qiangrong Liang; Zongwen Tian; Kathleen M Horak; Jeffery D Molkentin; Xuejun Wang
Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts.
Cardiovascular research 2010;88(3):424-33.
2010: Erin R Wissing; Douglas P Millay; Grégoire Vuagniaux; Jeffery D Molkentin
Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice.
Neuromuscular disorders : NMD 2010;20(11):753-60.
2010: Jop H van Berlo; John Elrod; Maarten M G van den Hoogenhof; Allen York; Bruce J Aronow; Stephen A Duncan; Jeffery D Molkentin
The transcription factor GATA-6 regulates pathological cardiac hypertrophy.
Circulation research 2010;107(8):1032-40.
2010: John Elrod; Renee Wong; Shikha Mishra; Ronald J Vagnozzi; Bhuvana Sakthievel; Sanjeewa A Goonasekera; Jason Karch; Scott Gabel; John Farber; Thomas Force; Joan Heller Brown; Elizabeth Murphy; Jeffery D Molkentin
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.
The Journal of clinical investigation 2010;120(10):3680-7.
2010: Hongyu Zhang; Xiongwen Chen; Erhe Gao; Scott M MacDonnell; Wei Wang; Mikhail Kolpakov; Hiroyuki Nakayama; Xiaoying Zhang; Naser Jaleel; David M Harris; Yingxin Li; Mingxin Tang; Remus M Berretta; Annarosa Leri; Jan Kajstura; Abdelkarim Sabri; Walter J Koch; Jeffery D Molkentin; Steven R Houser
Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction.
Circulation research 2010;107(6):800-9.
2010: Thomas Force; Robert O Bonow; Steven R Houser; R John Solaro; Ray E Hershberger; Bishow Adhikari; Mark E Anderson; Robin Boineau; Barry J Byrne; Thomas P Cappola; Raghu Kalluri; Martin M LeWinter; Martin S Maron; Jeffery D Molkentin; Steve R Ommen; Michael Regnier; W H Wilson Tang; Rong Tian; Marvin A Konstam; Barry J Maron; Christine E Seidman
Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.
Circulation 2010;122(11):1130-3.
2010: Hiroyuki Nakayama; Ilona Bodi; Marjorie Maillet; Jaime DeSantiago; Timothy L Domeier; Katsuhiko Mikoshiba; John N Lorenz; Lothar A Blatter; Donald M Bers; Jeffery D Molkentin
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.
Circulation research 2010;107(5):659-66.
2010: Tao Sun; Xin-Sheng Wu; Jianhua Xu; Benjamin D McNeil; Zhiping Pang; Wanjun Yang; Li Bai; Syed Qadri; Jeffery D Molkentin; David T Yue; Ling-Gang Wu
The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(35):11838-47.
2010: Jörg Heineke; Mannix Auger-Messier; Robert N Correll; Jian Xu; Matthew J Benard; Weiping Yuan; Helmut Drexler; Leslie V Parise; Jeffery D Molkentin
CIB1 is a regulator of pathological cardiac hypertrophy.
Nature medicine 2010;16(8):872-9.
2010: Mingxin Tang; Xiaoying Zhang; Yingxin Li; Yinzheng Guan; Xiaojie Ai; Christopher Szeto; Hiroyuki Nakayama; Hongyu Zhang; Shuping Ge; Jeffery D Molkentin; Steven R Houser; Xiongwen Chen
Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity.
American journal of physiology. Heart and circulatory physiology 2010;299(2):H519-28.
2010: Kristin B Andersson; Lisbeth H Winer; Halvor K Mørk; Jeffery D Molkentin; Frédéric Jaisser
Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts.
Transgenic research 2010;19(4):715-25.
2010: Karen Gilio; Matthew Harper; Judith M E M Cosemans; Olga Konopatskaya; Imke C A Munnix; Lenneke Prinzen; Michael Leitges; Qinghang Liu; Jeffery D Molkentin; Johan W M Heemskerk; Alastair W Poole
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.
The Journal of biological chemistry 2010;285(30):23410-9.
2010: Andreas Rinne; Nidhi Kapur; Jeffery D Molkentin; Steven M Pogwizd; Donald M Bers; Kathrin Banach; Lothar A Blatter
Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure.
American journal of physiology. Heart and circulatory physiology 2010;298(6):H2001-9.
2010: Melissa N Quinsay; Youngil Lee; Shivaji Rikka; M Richard Sayen; Jeffery D Molkentin; Roberta Anne Gottlieb; Asa B Gustafsson
Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism.
Journal of molecular and cellular cardiology 2010;48(6):1146-56.
2010: Joerg Heineke; Kai C Wollert; Hanna Osinska; Michelle A Sargent; Allen York; Jeffrey Robbins; Jeffery D Molkentin
Calcineurin protects the heart in a murine model of dilated cardiomyopathy.
Journal of molecular and cellular cardiology 2010;48(6):1080-7.
2010: Richard N Kitsis; Jeffery D Molkentin
Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9031-2.
2010: Richard Tsika; Lixin Ma; Izhak Kehat; Christine Schramm; Gretchen Simmer; Brandon Morgan; Deborah M Fine; Laurin M Hanft; Kerry S McDonald; Jeffery D Molkentin; Maike Krenz; Steve Yang; Juan Ji
TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.
The Journal of biological chemistry 2010;285(18):13721-35.
2010: Xu Wu; Petra Eder; Baojun Chang; Jeffery D Molkentin
TRPC channels are necessary mediators of pathologic cardiac hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):7000-5.
2010: Manuel F Navedo; Edward P Cheng; Can Yuan; Scott Votaw; Jeffery D Molkentin; John D Scott; Luis F Santana
Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome.
Circulation research 2010;106(4):748-56.
2010: Marjorie Maillet; Jennifer Davis; Mannix Auger-Messier; Allen York; Hanna Osinska; Jérôme Piquereau; John N Lorenz; Jeffrey Robbins; Renée Ventura-Clapier; Jeffery D Molkentin
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.
The Journal of biological chemistry 2010;285(9):6716-24.
2010: Izhak Kehat; Jeffery D Molkentin
Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy.
Annals of the New York Academy of Sciences 2010;1188():96-102.
2010: Manuel F Navedo; Yukari Takeda; Madeline Nieves-Cintrón; Jeffery D Molkentin; Luis F Santana
Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells.
American journal of physiology. Cell physiology 2010;298(2):C211-20.
2010: Jörg Heineke; Mannix Auger-Messier; Jian Xu; Michelle Sargent; Allen York; Stephen Welle; Jeffery D Molkentin
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure.
Circulation 2010;121(3):419-25.
2009: Victor J Dzau; Jeffery D Molkentin
Helmut Drexler, MD, 1951-2009.
Circulation 2009;120(23):2402-3.
2009: Jiang Qian; Xiaoping Ren; Xiaohong Wang; Pengyuan Zhang; W Keith Jones; Jeffery D Molkentin; Guo-Chang Fan; Evangelia G Kranias
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.
Circulation research 2009;105(12):1223-31.
2009: Hiroyuki Nakayama; Ilona Bodi; Robert N Correll; Xiongwen Chen; John Lorenz; Steven R Houser; Jeffrey Robbins; Arnold Schwartz; Jeffery D Molkentin
alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice.
The Journal of clinical investigation 2009;119(12):3787-96.
2009: Qinghang Liu; Michelle A Sargent; Allen J York; Jeffery D Molkentin
ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice.
Circulation research 2009;105(11):1110-7.
2009: Douglas P Millay; Sanjeewa A Goonasekera; Michelle A Sargent; Marjorie Maillet; Bruce Aronow; Jeffery D Molkentin
Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(45):19023-8.
2009: Tatiana V Tkatchenko; Ricardo A Moreno-Rodriguez; Simon J Conway; Jeffery D Molkentin; Roger R Markwald; Andrei V Tkatchenko
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
Physiological genomics 2009;39(3):160-8.
2009: Douglas P Millay; Marjorie Maillet; Joseph Roche; Michelle A Sargent; Elizabeth M McNally; Robert J Bloch; Jeffery D Molkentin
Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy.
The American journal of pathology 2009;175(5):1817-23.
2009: Ricardo J Gelpi; Shumin Gao; Peiyong Zhai; Lin Yan; Chull Hong; Lauren M A Danridge; Hui Ge; Yasahiro Maejima; Martin Donato; Mitsuhiro Yokota; Jeffery D Molkentin; Dorothy E Vatner; Stephen F Vatner; Junichi Sadoshima
Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.
American journal of physiology. Heart and circulatory physiology 2009;297(5):H1814-9.
2009: Arunima Sengupta; Jeffery D Molkentin; Katherine E Yutzey
FoxO transcription factors promote autophagy in cardiomyocytes.
The Journal of biological chemistry 2009;284(41):28319-31.
2009: Marjorie Maillet; Jeffrey M Lynch; Bastiano Sanna; Allen J York; Yi Zheng; Jeffery D Molkentin
Cdc42 is an antihypertrophic molecular switch in the mouse heart.
The Journal of clinical investigation 2009;119(10):3079-88.
2009: Scott M MacDonnell; Jutta Weisser-Thomas; Hajime Kubo; Marie Hanscome; Qinghang Liu; Naser Jaleel; Remus M Berretta; Xiongwen Chen; Joan H Brown; Abdel-Karim Sabri; Jeffery D Molkentin; Steven R Houser
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.
Circulation research 2009;105(4):316-25.
2009: Kristin B Andersson; Jon Arne Kro Birkeland; Alexandra Vanessa Finsen; William E Louch; Ivar Sjaastad; Yibin Wang; Ju Chen; Jeffery D Molkentin; Kenneth R Chien; Ole M Sejersted; Geir Christensen
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
Journal of molecular and cellular cardiology 2009;47(2):180-7.
2009: Lee J Martin; Barry Gertz; Yan Pan; Ann C Price; Jeffery D Molkentin; Qing Chang
The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice.
Experimental neurology 2009;218(2):333-46.
2009: Qinghang Liu; Xiongwen Chen; Scott M Macdonnell; Evangelia G Kranias; John N Lorenz; Michael Leitges; Steven R Houser; Jeffery D Molkentin
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Circulation research 2009;105(2):194-200.
2009: Christopher P Baines; Jeffery D Molkentin
Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax.
Journal of molecular and cellular cardiology 2009;46(6):969-77.
2009: Kaoru Ito; Hiroshi Akazawa; Masaji Tamagawa; Kensuke Furukawa; Wataru Ogawa; Noritaka Yasuda; Yoko Kudo; Chien-hui Liao; Rie Yamamoto; Toshiaki Sato; Jeffery D Molkentin; Masato Kasuga; Tetsuo Noda; Haruaki Nakaya; Issei Komuro
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8689-94.
2009: Xu Wu; Baojun Chang; N Scott Blair; Michelle Sargent; Allen J York; Jeffrey Robbins; Gary E Shull; Jeffery D Molkentin
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.
The Journal of clinical investigation 2009;119(4):976-85.
2009: Sakthivel Sadayappan; James Gulick; Raisa Klevitsky; John N Lorenz; Michelle Sargent; Jeffery D Molkentin; Jeffrey Robbins
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.
Circulation 2009;119(9):1253-62.
2009: Leticia A M Carneiro; Leonardo H Travassos; Fraser Soares; Ivan Tattoli; Joao G Magalhaes; Marcelo T Bozza; Maria C Plotkowski; Philippe J Sansonetti; Jeffery D Molkentin; Dana J Philpott; Stephen E Girardin
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells.
Cell host & microbe 2009;5(2):123-36.
2009: Olga Konopatskaya; Karen Gilio; Matthew Harper; Yan Zhao; Judith M E M Cosemans; Zubair A Karim; Sidney W Whiteheart; Jeffery D Molkentin; Paul Verkade; Steve P Watson; Johan W M Heemskerk; Alastair W Poole
PKCalpha regulates platelet granule secretion and thrombus formation in mice.
The Journal of clinical investigation 2009;119(2):399-407.
2009: Qinghang Liu; Jennifer Caldwell Busby; Jeffery D Molkentin
Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.
Nature cell biology 2009;11(2):154-61.
2009: Steven Hsu; Takahiro Nagayama; Norimichi Koitabashi; Manling Zhang; Liye Zhou; Djahida Bedja; Kathleen L Gabrielson; Jeffery D Molkentin; David A Kass; Eiki Takimoto
Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.
Cardiovascular research 2009;81(2):301-9.
2009: Jeffery D Molkentin; Jeffrey Robbins
With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure.
Journal of molecular and cellular cardiology 2009;46(2):130-6.
2009: Cam Donaldson; Sarah Eder; Corey Baker; Mark Aronovitz; Alexandra Dabreo Weiss; Monica Hall-Porter; Feng Wang; Adam Ackerman; Richard H Karas; Jeffery D Molkentin; Richard D Patten
Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.
Circulation research 2009;104(2):265-75, 11p following 275.
2009: Yong Jun Yang; Wei Chen; Alexander Edgar; Bo Li; Jeffery D Molkentin; Jason N Berman; Tong-Jun Lin
Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function.
The Journal of experimental medicine 2009;206(1):195-207.
2009: Angela Lorts; Jennifer A Schwanekamp; John Elrod; Michelle A Sargent; Jeffery D Molkentin
Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair.
Circulation research 2009;104(1):e1-7.
2009: Abhinav Diwan; Scot J Matkovich; Qunying Yuan; Wen Zhao; Atsuko Yatani; Joan Heller Brown; Jeffery D Molkentin; Evangelia G Kranias; Gerald W Dorn
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death.
The Journal of clinical investigation 2009;119(1):203-12.
2008: Maike Krenz; James Gulick; Hanna Osinska; Melissa C Colbert; Jeffery D Molkentin; Jeffrey Robbins
Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18930-5.
2008: Simon J Conway; Jeffery D Molkentin
Periostin as a heterofunctional regulator of cardiac development and disease.
Current genomics 2008;9(8):548-55.
2008: Naser Jaleel; Hiroyuki Nakayama; Xiongwen Chen; Hajime Kubo; Scott M MacDonnell; Hongyu Zhang; Remus M Berretta; Jeffrey Robbins; Leanne Cribbs; Jeffery D Molkentin; Steven R Houser
Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.
Circulation research 2008;103(10):1109-19.
2008: Marjorie Maillet; Nicole H Purcell; Michelle A Sargent; Allen J York; Orlando F Bueno; Jeffery D Molkentin
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility.
The Journal of biological chemistry 2008;283(45):31246-55.
2008: Madeline Nieves-Cintrón; Gregory C Amberg; Manuel F Navedo; Jeffery D Molkentin; Luis F Santana
The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15623-8.
2008: Paula A da Costa Martins; Meriem Bourajjaj; Monika Gladka; Mara Kortland; Ralph J van Oort; Yigal M Pinto; Jeffery D Molkentin; Leon J De Windt
Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling.
Circulation 2008;118(15):1567-76.
2008: Heng Du; Lan Guo; Fang Fang; Doris Chen; Alexander A Sosunov; Guy M McKhann; Yilin Yan; Chunyu Wang; Hong Zhang; Jeffery D Molkentin; Frank J Gunn-Moore; Jean-Paul Vonsattel; Ottavio Arancio; John Xi Chen; Shi Du Yan
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Nature medicine 2008;14(10):1097-105.
2008: Stephen J Fuller; Sampsa Pikkarainen; El Li Tham; Timothy E Cullingford; Jeffery D Molkentin; Hauke Cornils; Alexander Hergovich; Brian A Hemmings; Angela Clerk; Peter H Sugden
Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.
Cellular signalling 2008;20(8):1564-77.
2008: Tetsuro Ago; Tong Liu; Peiyong Zhai; Wei Chen; Hong Li; Jeffery D Molkentin; Stephen F Vatner; Junichi Sadoshima
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.
Cell 2008;133(6):978-93.
2008: Paige Snider; Robert B Hinton; Ricardo A Moreno-Rodriguez; Jian Wang; Rhonda Rogers; Andrew Lindsley; Fang Li; David A Ingram; Donald R Menick; Loren Field; Anthony B Firulli; Jeffery D Molkentin; Roger R Markwald; Simon J Conway
Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.
Circulation research 2008;102(7):752-60.
2008: Douglas P Millay; Michelle A Sargent; Hanna Osinska; Christopher P Baines; Elisabeth R Barton; Grégoire Vuagniaux; H Lee Sweeney; Jeffrey Robbins; Jeffery D Molkentin
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.
Nature medicine 2008;14(4):442-7.
2008: Bogachan Sahin; Ammar H Hawasli; Robert W Greene; Jeffery D Molkentin; James A Bibb
Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C.
European journal of pharmacology 2008;581(3):270-5.
2008: Ilka Pinz; Sanford E Ostroy; Kirsten Hoyer; Hanna Osinska; Jeffrey Robbins; Jeffery D Molkentin; Joanne S Ingwall
Calcineurin-induced energy wasting in a transgenic mouse model of heart failure.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1459-66.
2008: Shawn Jobe; Katina M Wilson; Lorie Leo; Alejandro Raimondi; Jeffery D Molkentin; Steven R Lentz; Jorge Di Paola
Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis.
Blood 2008;111(3):1257-65.
2008: Steven R Houser; Jeffery D Molkentin
Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?
Science signaling 2008;1(25):pe31.
2008: Beatriz Morancho; Jordi Minguillón; Jeffery D Molkentin; Cristina López-Rodríguez; Jose Aramburu
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.
BMC molecular biology 2008;9():13.
2008: santhakumar manicassamy; Sonal Gupta; Zhaofeng Huang; Jeffery D Molkentin; Weirong Shang; Zuoming Sun
Requirement of calcineurin a beta for the survival of naive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):106-12.
2008: Grzegorz T Gurda; Lili Guo; Sae-Hong Lee; Jeffery D Molkentin; John Williams
Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo.
Molecular biology of the cell 2008;19(1):198-206.
2007: Michael Hambleton; Allen York; Michelle A Sargent; Robert A Kaiser; John N Lorenz; Jeffrey Robbins; Jeffery D Molkentin
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3768-71.
2007: Jörg Heineke; Mannix Auger-Messier; Jian Xu; Toru Oka; Michelle A Sargent; Allen York; Raisa Klevitsky; Sachin Vaikunth; Stephen A Duncan; Bruce Aronow; Jeffrey Robbins; Timothy M Crombleholme; Timothy M Cromblehol; Jeffery D Molkentin
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.
The Journal of clinical investigation 2007;117(11):3198-210.
2007: Hiroyuki Nakayama; Xiongwen Chen; Christopher P Baines; Raisa Klevitsky; Xiaoying Zhang; Hongyu Zhang; Naser Jaleel; Balvin H L Chua; Timothy E Hewett; Jeffrey Robbins; Steven R Houser; Jeffery D Molkentin
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.
The Journal of clinical investigation 2007;117(9):2431-44.
2007: Nicole H Purcell; Benjamin J Wilkins; Allen York; Marc K Saba-El-Leil; Sylvain Meloche; Jeffrey Robbins; Jeffery D Molkentin
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14074-9.
2007: Toru Oka; Jian Xu; Robert A Kaiser; Jaime Melendez; Michael Hambleton; Michelle A Sargent; Angela Lorts; Eric W Brunskill; Gerald W Dorn; Simon J Conway; Bruce Aronow; Jeffrey Robbins; Jeffery D Molkentin
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.
Circulation research 2007;101(3):313-21.
2007: Patrick C H Hsieh; Vincent F M Segers; Michael E Davis; Catherine MacGillivray; Joseph Gannon; Jeffery D Molkentin; Jeffrey Robbins; Richard T Lee
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury.
Nature medicine 2007;13(8):970-4.
2007: Tomoki Nakamura; Melissa C Colbert; Maike Krenz; Jeffery D Molkentin; Harvey S Hahn; Gerald W Dorn; Jeffrey Robbins
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
The Journal of clinical investigation 2007;117(8):2123-32.
2007: Russell A Norris; Brook Damon; Vladimir Mironov; Vladimir Kasyanov; Anand Ramamurthi; Ricardo Moreno-Rodriguez; Thomas C Trusk; Jay D Potts; Richard L Goodwin; Jeff Davis; Stanley Hoffman; Xuejun Wen; Yukiko Sugi; Christine B Kern; Corey H Mjaatvedt; Debi K Turner; Toru Oka; Simon J Conway; Jeffery D Molkentin; gabor forgacs; Roger R Markwald
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues.
Journal of cellular biochemistry 2007;101(3):695-711.
2007: Christopher P Baines; Robert A Kaiser; Tatiana V Sheiko; William J Craigen; Jeffery D Molkentin
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.
Nature cell biology 2007;9(5):550-5.
2007: Abhinav Diwan; Andrew G Koesters; Amy Odley; Suvarnamala Pushkaran; Christopher P Baines; Benjamin T Spike; Diedre Daria; anil jegga; Hartmut Geiger; Bruce Aronow; Jeffery D Molkentin; Kay F Macleod; Theodosia A Kalfa; Gerald W Dorn
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6794-9.
2007: Stephanie Parsons; Douglas P Millay; Michelle A Sargent; Francisco J Naya; Elizabeth McNally; H Lee Sweeney; Jeffery D Molkentin
Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy.
The Journal of biological chemistry 2007;282(13):10068-78.
2007: Masanori Sano; Tohru Minamino; Haruhiro Toko; Hideyuki Miyauchi; Masayuki Orimo; Yingjie Qin; Hiroshi Akazawa; Kaoru Tateno; Yosuke Kayama; Mutsuo Harada; Ippei Shimizu; Takayuki Asahara; Hirofumi Hamada; Shuhei Tomita; Jeffery D Molkentin; Yunzeng Zou; Issei Komuro
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.
Nature 2007;446(7134):444-8.
2007: Lisa M Nilsson; Zheng-Wu Sun; Jenny Nilsson; Ina Nordström; Yung-Wu Chen; Jeffery D Molkentin; Dag Wide-Swensson; Per Hellstrand; Marie-Louise Lydrup; Maria F Gomez
Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation.
American journal of physiology. Cell physiology 2007;292(3):C1167-78.
2007: Gregory C Amberg; Manuel F Navedo; Madeline Nieves-Cintrón; Jeffery D Molkentin; Luis F Santana
Calcium sparklets regulate local and global calcium in murine arterial smooth muscle.
The Journal of physiology 2007;579(Pt 1):187-201.
2007: Jun Peng; Katy Raddatz; Jeffery D Molkentin; Yiming Wu; Siegfried Labeit; Henk Granzier; Michael Gotthardt
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Circulation 2007;115(6):743-51.
2007: Madeline Nieves-Cintrón; Gregory C Amberg; C Blake Nichols; Jeffery D Molkentin; Luis F Santana
Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension.
The Journal of biological chemistry 2007;282(5):3231-40.
2007: Toru Oka; Jian Xu; Jeffery D Molkentin
Re-employment of developmental transcription factors in adult heart disease.
Seminars in cell & developmental biology 2007;18(1):117-31.
2007: Dingding Xiong; Toshitaka Yajima; Byung-Kwan Lim; Antine Elaine Stenbit; Andrew Dublin; Nancy Dalton; Daphne Summers-Torres; Jeffery D Molkentin; Hervé Duplain; Rainer Wessely; Ju Chen; Kirk U Knowlton
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy.
Circulation 2007;115(1):94-102.
2006: Nanling Gong; Ilona Bodi; Carsten Zobel; Arnold Schwartz; Jeffery D Molkentin; Peter H Backx
Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits.
The Journal of biological chemistry 2006;281(50):38498-506.
2006: Sakthivel Sadayappan; Hanna Osinska; Raisa Klevitsky; John N Lorenz; Michelle A Sargent; Jeffery D Molkentin; Christine E Seidman; Jonathan G Seidman; Jeffrey Robbins
Cardiac myosin binding protein C phosphorylation is cardioprotective.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16918-23.
2006: Hye-Lim Noh; Kazue Okajima; Jeffery D Molkentin; Shunichi Homma; Sunichi Homma; Ira J Goldberg
Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction.
American journal of physiology. Endocrinology and metabolism 2006;291(4):E755-60.
2006: Kofo Obasanjo-Blackshire; Rui Mesquita; Rita I Jabr; Jeffery D Molkentin; Stephen L Hart; Michael S Marber; Yang Xia; Richard J Heads
Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase.
Cardiovascular research 2006;71(4):672-83.
2006: Bogachan Sahin; Hongjun Shu; Joseph Fernandez; Ali El-Armouche; Jeffery D Molkentin; Angus Nairn; James A Bibb
Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.
The Journal of biological chemistry 2006;281(34):24322-35.
2006: Michael Hambleton; Harvey Hahn; Sven T Pleger; Matthew C Kuhn; Raisa Klevitsky; Andrew N Carr; Thomas F Kimball; Timothy E Hewett; Gerald W Dorn; Walter J Koch; Jeffery D Molkentin
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Circulation 2006;114(6):574-82.
2006: Jörg Heineke; Jeffery D Molkentin
Regulation of cardiac hypertrophy by intracellular signalling pathways.
Nature reviews. Molecular cell biology 2006;7(8):589-600.
2006: Hiroyuki Nakayama; Benjamin J Wilkin; Ilona Bodi; Jeffery D Molkentin
Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1660-70.
2006: Mei Xin; Christopher A Davis; Jeffery D Molkentin; Ching-Ling Lien; Stephen A Duncan; James A Richardson; Eric N Olson
A threshold of GATA4 and GATA6 expression is required for cardiovascular development.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11189-94.
2006: Xin Chen; Sergei P Shevtsov; Eileen Hsich; Lei Cui; Syed Haq; Mark Aronovitz; Risto Kerkelä; Jeffery D Molkentin; Ronglih Liao; Robert N Salomon; Richard D Patten; Thomas Force
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.
Molecular and cellular biology 2006;26(12):4462-73.
2006: Stephanie Parsons; Douglas P Millay; Michelle A Sargent; Elizabeth McNally; Jeffery D Molkentin
Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy.
The American journal of pathology 2006;168(6):1975-85.
2006: Manuel F Navedo; Gregory C Amberg; Madeline Nieves; Jeffery D Molkentin; Luis F Santana
Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle.
The Journal of general physiology 2006;127(6):611-22.
2006: Bastiano Sanna; Eric B Brandt; Robert A Kaiser; Paul Pfluger; Sandra A Witt; Thomas R Kimball; Eva van Rooij; Leon J De Windt; Marc E Rothenberg; Matthias H Tschop; Stephen C Benoit; Jeffery D Molkentin
Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7327-32.
2006: Qinghang Liu; Benjamin J Wilkins; Yong J Lee; Hidenori Ichijo; Jeffery D Molkentin
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.
Molecular and cellular biology 2006;26(10):3785-97.
2006: Jian Xu; Nanling Gong; Ilona Bodi; Bruce Aronow; Peter H Backx; Jeffery D Molkentin
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice.
The Journal of biological chemistry 2006;281(14):9152-62.
2006: Jenny Nilsson; Lisa M Nilsson; Yung-Wu Chen; Jeffery D Molkentin; David Erlinge; Maria F Gomez
High glucose activates nuclear factor of activated T cells in native vascular smooth muscle.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):794-800.
2006: Toru Oka; Marjorie Maillet; Alistair J Watt; Robert J Schwartz; Bruce Aronow; Stephen A Duncan; Jeffery D Molkentin
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.
Circulation research 2006;98(6):837-45.
2006: Jeffery D Molkentin
Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling.
The Journal of clinical investigation 2006;116(3):623-6.
2006: Wen Zhao; Qunying Yuan; Jiang Qian; Jason R Waggoner; Anand Pathak; Guoxiang Chu; Bryan Mitton; Xiaoyin Sun; Jay Jin; Julian C Braz; Harvey S Hahn; Yehia Marreez; Faisal M Syed; Piero Pollesello; Arto Annila; Hong-Sheng Wang; Jo El J Schultz; Jeffery D Molkentin; Stephen B Liggett; Gerald W Dorn; Evangelia G Kranias
The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Circulation 2006;113(7):995-1004.
2006: Jian Xu; Thomas R Kimball; John N Lorenz; David A Brown; Asne R Bauskin; Raisa Klevitsky; Timothy E Hewett; Samuel N Breit; Jeffery D Molkentin
GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.
Circulation research 2006;98(3):342-50.
2006: Tibor Kempf; Matthias Eden; Jens Strelau; Marian Naguib; Christian Willenbockel; Jörn Tongers; Jörg Heineke; Daniel Kotlarz; Jian Xu; Jeffery D Molkentin; Hans W Niessen; Helmut Drexler; Kai C Wollert
The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury.
Circulation research 2006;98(3):351-60.
2005: Jeffery D Molkentin
Locating heart failure.
Nature medicine 2005;11(12):1284-5.
2005: Robert A Kaiser; Jefferson M Lyons; Jodie Y Duffy; Connie J Wagner; Kelly M McLean; Timothy P O'Neill; Jeffrey M Pearl; Jeffery D Molkentin
Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2747-51.
2005: Ara Parlakian; Claude Charvet; Brigitte Escoubet; Mathias Mericskay; Jeffery D Molkentin; Guillaume Gary-Bobo; Leon J De Windt; Marie-Aline Ludosky; D Paulin; Dominique Daegelen; David Tuil; Zhenlin Li
Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart.
Circulation 2005;112(19):2930-9.
2005: Yan-Shan Dai; Jian Xu; Jeffery D Molkentin
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.
Molecular and cellular biology 2005;25(22):9936-48.
2005: Robert A Kaiser; Qiangrong Liang; Orlando F Bueno; Yuan Huang; Troy Lackey; Raisa Klevitsky; Timothy E Hewett; Jeffery D Molkentin
Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo.
The Journal of biological chemistry 2005;280(38):32602-8.
2005: Jifen Li; Vickas V Patel; Igor Kostetskii; Yanming Xiong; Antony F Chu; Jason T Jacobson; Cindy Yu; Gregory E Morley; Jeffery D Molkentin; Glenn L Radice
Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis.
Circulation research 2005;97(5):474-81.
2005: Toru Oka; Yan-Shan Dai; Jeffery D Molkentin
Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo.
Molecular and cellular biology 2005;25(15):6649-59.
2005: Jeffrey Lynch; Lei Guo; Pascal Gelebart; Kaari A Chilibeck; Jian Xu; Jeffery D Molkentin; Luis B Agellon; Marek Michalak
Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade.
The Journal of cell biology 2005;170(1):37-47.
2005: Samuel M Pope; Patricia C Fulkerson; Carine Blanchard; Hiroko Saito Akei; Nikolaos M Nikolaidis; Nives Zimmermann; Jeffery D Molkentin; Marc E Rothenberg
Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation.
The Journal of biological chemistry 2005;280(14):13952-61.
2005: Christopher P Baines; Robert A Kaiser; Nicole H Purcell; N Scott Blair; Hanna Osinska; Michael Hambleton; Eric W Brunskill; M Richard Sayen; Roberta Anne Gottlieb; Gerald W Dorn; Jeffrey Robbins; Jeffery D Molkentin
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.
Nature 2005;434(7033):658-62.
2005: Igor Kostetskii; Jifen Li; Yanming Xiong; Rong Zhou; Victor A Ferrari; Vickas V Patel; Jeffery D Molkentin; Glenn L Radice
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure.
Circulation research 2005;96(3):346-54.
2005: Jörg Heineke; Hartmut Ruetten; Christian Willenbockel; Sandra C Gross; Marian Naguib; Arnd Schaefer; Tibor Kempf; Denise Hilfiker-Kleiner; Pico Caroni; Theresia Kraft; Robert A Kaiser; Jeffery D Molkentin; Helmut Drexler; Kai C Wollert
Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1655-60.
2005: Bastiano Sanna; Orlando F Bueno; Yan-Shan Dai; Benjamin J Wilkins; Jeffery D Molkentin
Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.
Molecular and cellular biology 2005;25(3):865-78.
2005: Osnat Bell; Elena Gaberman; Rachel Kilav; Ronen Levi; Keith B Cox; Jeffery D Molkentin; Justin Silver; Tally Naveh-Many
The protein phosphatase calcineurin determines basal parathyroid hormone gene expression.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):516-26.
2005: Christopher P Baines; Jeffery D Molkentin
STRESS signaling pathways that modulate cardiac myocyte apoptosis.
Journal of molecular and cellular cardiology 2005;38(1):47-62.
2005: Marianne Nimah; Bin Zhao; Alvin Denenberg; Orlando Bueno; Jeffery D Molkentin; Hector R Wong; Thomas P Shanley
Contribution of MKP-1 regulation of p38 to endotoxin tolerance.
Shock (Augusta, Ga.) 2005;23(1):80-7.
2005: Lin Zhang; Maoxian Deng; Ranjani Parthasarathy; Lei Wang; Maureen Mongan; Jeffery D Molkentin; Yi Zheng; Ying Xia
MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.
Molecular and cellular biology 2005;25(1):60-5.
2004: Yulia Moz; Ronen Levi; Vardit Lavi-Moshayoff; Keith B Cox; Jeffery D Molkentin; Justin Silver; Tally Naveh-Many
Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport.
Journal of the American Society of Nephrology : JASN 2004;15(12):2972-80.
2004: Katsuhisa Matsuura; Hiroshi Wada; Toshio Nagai; Yoshihiro Iijima; Tohru Minamino; Masanori Sano; Hiroshi Akazawa; Jeffery D Molkentin; Hiroshi Kasanuki; Issei Komuro
Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle.
The Journal of cell biology 2004;167(2):351-63.
2004: Benjamin J Wilkins; Jeffery D Molkentin
Calcium-calcineurin signaling in the regulation of cardiac hypertrophy.
Biochemical and biophysical research communications 2004;322(4):1178-91.
2004: Jeffery D Molkentin
Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs.
Cardiovascular research 2004;63(3):467-75.
2004: Stephanie Parsons; Douglas P Millay; Benjamin J Wilkins; Orlando F Bueno; Gretchen L Tsika; Joel R Neilson; Christine M Liberatore; Katherine E Yutzey; Gerald R Crabtree; Richard Tsika; Jeffery D Molkentin
Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.
The Journal of biological chemistry 2004;279(25):26192-200.
2004: Ashour Michael; Syed Haq; Xin Chen; Eileen Hsich; Lei Cui; Brian Walters; Zhili Shao; Kausik Bhattacharya; Heiko Kilter; Gordon S Huggins; Michele Andreucci; Muthu Periasamy; Robert N Solomon; Ronglih Liao; Richard D Patten; Jeffery D Molkentin; Thomas Force
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
The Journal of biological chemistry 2004;279(20):21383-93.
2004: Daniel J Lips; Orlando F Bueno; Benjamin J Wilkins; Nicole H Purcell; Robert A Kaiser; John N Lorenz; Laure Voisin; Marc K Saba-El-Leil; Sylvain Meloche; Jacques Pouysségur; Gilles Pagès; Leon J De Windt; Pieter A Doevendans; Jeffery D Molkentin
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.
Circulation 2004;109(16):1938-41.
2004: Parinaz Aliahmad; Emmett O'Flaherty; Peggy Han; Olivia D Goularte; Beverley Wilkinson; Masanobu Satake; Jeffery D Molkentin; Jonathan Kaye
TOX provides a link between calcineurin activation and CD8 lineage commitment.
The Journal of experimental medicine 2004;199(8):1089-99.
2004: Robert A Kaiser; Orlando F Bueno; Daniel J Lips; Pieter A Doevendans; Fred Jones; Thomas F Kimball; Jeffery D Molkentin
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.
The Journal of biological chemistry 2004;279(15):15524-30.
2004: Julian C Braz; Kimberly Gregory; Anand Pathak; Wen Zhao; Bogachan Sahin; Raisa Klevitsky; Thomas F Kimball; John N Lorenz; Angus Nairn; Stephen B Liggett; Ilona Bodi; Su Wang; Arnold Schwartz; Edward G Lakatta; Anna A DePaoli-Roach; Jeffrey Robbins; Timothy E Hewett; James A Bibb; Margaret V Westfall; Evangelia G Kranias; Jeffery D Molkentin
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2004: Alexander W Lange; Jeffery D Molkentin; Katherine E Yutzey
DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice.
Developmental biology 2004;266(2):346-60.
2004: Nicole H Purcell; Dina Darwis; Orlando F Bueno; Judith M Müller; Roland Schüle; Jeffery D Molkentin
Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.
Molecular and cellular biology 2004;24(3):1081-95.
2004: Gerald W Dorn; Jeffery D Molkentin
Manipulating cardiac contractility in heart failure: data from mice and men.
Circulation 2004;109(2):150-8.
2004: Benjamin J Wilkins; Yan-Shan Dai; Orlando F Bueno; Stephanie Parsons; Jian Xu; David M Plank; Fred Jones; Thomas R Kimball; Jeffery D Molkentin
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.
Circulation research 2004;94(1):110-8.
2004: Orlando F Bueno; Daniel J Lips; Robert A Kaiser; Benjamin J Wilkins; Yan-Shan Dai; Betty J Glascock; Raisa Klevitsky; Timothy E Hewett; Thomas R Kimball; Bruce Aronow; Pieter A Doevendans; Jeffery D Molkentin
Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction.
Circulation research 2004;94(1):91-9.
2003: Qiangrong Liang; Jeffery D Molkentin
Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models.
Journal of molecular and cellular cardiology 2003;35(12):1385-94.
2003: Qiangrong Liang; Orlando F Bueno; Benjamin J Wilkins; Chia-Yi Kuan; Ying Xia; Jeffery D Molkentin
c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.
The EMBO journal 2003;22(19):5079-89.
2003: Rethinasamy Prabhakar; Natalia N Petrashevskaya; Arnold Schwartz; Bruce Aronow; Gregory P Boivin; Jeffery D Molkentin; David F Wieczorek
A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation.
Molecular and cellular biochemistry 2003;251(1-2):33-42.
2003: Nicole H Purcell; Jeffery D Molkentin
Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?
Circulation 2003;108(6):638-40.
2003: Syed Haq; Heiko Kilter; Ashour Michael; Jingzang Tao; Eileen O'Leary; Xio Ming Sun; Brian Walters; Kausik Bhattacharya; Xin Chen; Lei Cui; Michele Andreucci; Anthony Rosenzweig; J Luis Guerrero; Richard D Patten; Ronglih Liao; Jeffery D Molkentin; Michael Picard; Joseph V Bonventre; Thomas Force
Deletion of cytosolic phospholipase A2 promotes striated muscle growth.
Nature medicine 2003;9(7):944-51.
2003: Paul B Bushdid; Hanna Osinska; Ronald R Waclaw; Jeffery D Molkentin; Katherine E Yutzey
NFATc3 and NFATc4 are required for cardiac development and mitochondrial function.
Circulation research 2003;92(12):1305-13.
2003: William Schubert; Xiao Yong Yang; Teddy T C Yang; Stephen M Factor; Michael P Lisanti; Jeffery D Molkentin; Mercedes Rincon; Chi-Wing Chow
Requirement of transcription factor NFAT in developing atrial myocardium.
The Journal of cell biology 2003;161(5):861-74.
2003: Stephanie Parsons; Benjamin J Wilkins; Orlando F Bueno; Jeffery D Molkentin
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.
Molecular and cellular biology 2003;23(12):4331-43.
2003: Yuichiro J Suzuki; Regina M Day; Chia Chi Tan; Tor H Sandven; Qiangrong Liang; Jeffery D Molkentin; Barry L Fanburg
Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells.
The Journal of biological chemistry 2003;278(19):17525-31.
2003: Julian C Braz; Orlando F Bueno; Qiangrong Liang; Benjamin J Wilkins; Yan-Shan Dai; Stephanie Parsons; Joseph Braunwart; Betty J Glascock; Raisa Klevitsky; Thomas F Kimball; Timothy E Hewett; Jeffery D Molkentin
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling.
The Journal of clinical investigation 2003;111(10):1475-86.
2003: Jeffery D Molkentin
A friend within the heart: natriuretic peptide receptor signaling.
The Journal of clinical investigation 2003;111(9):1275-7.
2003: Vitalyi O Rybin; Abdelkarim Sabri; Jacob Short; Julian C Braz; Jeffery D Molkentin; Susan F Steinberg
Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations.
The Journal of biological chemistry 2003;278(16):14555-64.
2003: Brian Petrich; Jeffery D Molkentin; Yibin Wang
Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):749-51.
2003: Kathleen Gajewski; Jianbo Wang; Jeffery D Molkentin; Elizabeth H Chen; Eric N Olson; Robert A Schulz
Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1040-5.
2003: Deli Dong; Yanjun Duan; Jiqing Guo; Daniel E Roach; Shauni L Swirp; Li Wang; James P Lees-Miller; Robert S Sheldon; Jeffery D Molkentin; Henry J Duff
Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels.
Cardiovascular research 2003;57(2):320-32.
2003: M Richard Sayen; Asa B Gustafsson; Mark A Sussman; Jeffery D Molkentin; Roberta Anne Gottlieb
Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production.
American journal of physiology. Cell physiology 2003;284(2):C562-70.
2003: Lisa M Semeniuk; David L Severson; Albert J Kryski; Shauni L Swirp; Jeffery D Molkentin; Henry J Duff
Time-dependent systolic and diastolic function in mice overexpressing calcineurin.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H425-30.
2002: Eva van Rooij; Pieter A Doevendans; Chiel C de Theije; Fawzi Babiker; Jeffery D Molkentin; Leon J De Windt
Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy.
The Journal of biological chemistry 2002;277(50):48617-26.
2002: Orlando F Bueno; Jeffery D Molkentin
Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death.
Circulation research 2002;91(9):776-81.
2002: Benjamin J Wilkins; Leon J De Windt; Orlando F Bueno; Julian C Braz; Betty J Glascock; Thomas F Kimball; Jeffery D Molkentin
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.
Molecular and cellular biology 2002;22(21):7603-13.
2002: Masuhiro Tomita; Martina I Reinhold; Jeffery D Molkentin; Michael Naski
Calcineurin and NFAT4 induce chondrogenesis.
The Journal of biological chemistry 2002;277(44):42214-8.
2002: Roy A Lynch; Lynne E Wagoner; Shunan Li; Li Sparks; Jeffery D Molkentin; Gerald W Dorn
Novel and nondetected human signaling protein polymorphisms.
Physiological genomics 2002;10(3):159-68.
2002: Asha Jacob; Jeffery D Molkentin; Albert Smolenski; Suzanne M Lohmann; Najma Begum
Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs.
American journal of physiology. Cell physiology 2002;283(3):C704-13.
2002: Beate Fiedler; Suzanne M Lohmann; Albert Smolenski; Stephan Linnemuller; Burkert Pieske; Frank Schroder; Jeffery D Molkentin; Helmut Drexler; Kai C Wollert
Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11363-8.
2002: Orlando F Bueno; Eric B Brandt; Marc E Rothenberg; Jeffery D Molkentin
Defective T cell development and function in calcineurin A beta -deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9398-403.
2002: Yan-Shan Dai; Peter Cserjesi; Bruce E Markham; Jeffery D Molkentin
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism.
The Journal of biological chemistry 2002;277(27):24390-8.
2002: Matthew J Donelan; Gerardo Morfini; Richard Julyan; Scott Sommers; Lori B Hays; Hiroshi Kajio; Isabelle Briaud; Richard Easom; Jeffery D Molkentin; Scott T Brady; Christopher J Rhodes
Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
The Journal of biological chemistry 2002;277(27):24232-42.
2002: Qiangrong Liang; Jeffery D Molkentin
Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression.
Journal of molecular and cellular cardiology 2002;34(6):611-6.
2002: Benjamin J Wilkins; Jeffery D Molkentin
Calcineurin and cardiac hypertrophy: where have we been? Where are we going?
The Journal of physiology 2002;541(Pt 1):1-8.
2002: Rajan Sah; Gavin Y Oudit; The-Tin T Nguyen; Hae W Lim; Alan D Wickenden; Gregory J Wilson; Jeffery D Molkentin; Peter H Backx
Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice.
Circulation 2002;105(15):1850-6.
2002: Orlando F Bueno; Benjamin J Wilkins; Kevin M Tymitz; Betty J Glascock; Thomas F Kimball; John N Lorenz; Jeffery D Molkentin
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4586-91.
2002: Natalia N Petrashevskaya; Ilona Bodi; Marta Rubio; Jeffery D Molkentin; Arnold Schwartz
Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse.
Cardiovascular research 2002;54(1):117-32.
2002: Guoxiang Chu; Andrew N Carr; Karen B Young; J William Lester; Atsuko Yatani; Atsushi Sanbe; Melissa C Colbert; Steven M Schwartz; Konrad Frank; Paul D Lampe; Jeffrey Robbins; Jeffery D Molkentin; Evangelia G Kranias
Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure.
Cardiovascular research 2002;54(1):105-16.
2002: Zamaneh Kassiri; Carsten Zobel; The-Tin T Nguyen; Jeffery D Molkentin; Peter H Backx
Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes.
Circulation research 2002;90(5):578-85.
2002: Julian C Braz; Orlando F Bueno; Leon J De Windt; Jeffery D Molkentin
PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2).
The Journal of cell biology 2002;156(5):905-19.
2002: Orlando F Bueno; Eva van Rooij; Jeffery D Molkentin; Pieter A Doevendans; Leon J De Windt
Calcineurin and hypertrophic heart disease: novel insights and remaining questions.
Cardiovascular research 2002;53(4):806-21.
2001: Qiangrong Liang; R J Wiese; Orlando F Bueno; Yan-Shan Dai; Bruce E Markham; Jeffery D Molkentin
The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.
Molecular and cellular biology 2001;21(21):7460-9.
2001: Qiangrong Liang; Leon J De Windt; SA Witt; T R Kimball; Bruce E Markham; Jeffery D Molkentin
The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.
The Journal of biological chemistry 2001;276(32):30245-53.
2001: D S Sohal; M Nghiem; M A Crackower; SA Witt; Thomas R Kimball; Kevin M Tymitz; J M Penninger; Jeffery D Molkentin
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein.
Circulation research 2001;89(1):20-5.
2001: HW Lim; L New; J Han; Jeffery D Molkentin
Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.
The Journal of biological chemistry 2001;276(19):15913-9.
2001: J Li; Jeffery D Molkentin; Melissa C Colbert
Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation.
Developmental biology 2001;232(2):351-61.
2001: Leon J De Windt; HW Lim; Orlando F Bueno; Qiangrong Liang; U Delling; Julian C Braz; Betty J Glascock; Thomas F Kimball; F del Monte; R J Hajjar; Jeffery D Molkentin
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3322-7.
2001: Syed Haq; G Choukroun; H Lim; K M Tymitz; Federica del Monte; Judith K Gwathmey; luanda grazette; Ashour Michael; Roger J Hajjar; Thomas Force; Jeffery D Molkentin
Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure.
Circulation 2001;103(5):670-7.
2001: Atsuko Yatani; R Honda; K M Tymitz; M Jane Lalli; Jeffery D Molkentin
Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway.
Journal of molecular and cellular cardiology 2001;33(2):249-59.
2001: Orlando F Bueno; Leon J De Windt; HW Lim; Kevin M Tymitz; SA Witt; Thomas R Kimball; Jeffery D Molkentin
The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo.
Circulation research 2001;88(1):88-96.
2000: Jeffery D Molkentin
The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.
The Journal of biological chemistry 2000;275(50):38949-52.
2000: Orlando F Bueno; Leon J De Windt; Kevin M Tymitz; SA Witt; Thomas R Kimball; Raisa Klevitsky; Timothy E Hewett; Steven P Jones; D J Lefer; Chang-Fu Peng; Richard N Kitsis; Jeffery D Molkentin
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.
The EMBO journal 2000;19(23):6341-50.
2000: Jeffery D Molkentin
Calcineurin and beyond: cardiac hypertrophic signaling.
Circulation research 2000;87(9):731-8.
2000: Syed Haq; G Choukroun; Z B Kang; Hardeep K Ranu; Takashi Matsui; Anthony Rosenzweig; Jeffery D Molkentin; Alessandro Alessandrini; James R Woodgett; Roger J Hajjar; Ashour Michael; Thomas Force
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy.
The Journal of cell biology 2000;151(1):117-30.
2000: U Delling; Jolana Tureckova; HW Lim; Leon J De Windt; Peter Rotwein; Jeffery D Molkentin
A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression.
Molecular and cellular biology 2000;20(17):6600-11.
2000: Jeffery D Molkentin; K M Tymitz; James A Richardson; Eric N Olson
Abnormalities of the genitourinary tract in female mice lacking GATA5.
Molecular and cellular biology 2000;20(14):5256-60.
2000: HW Lim; Leon J De Windt; L Steinberg; T Taigen; Sandra A Witt; T R Kimball; Jeffery D Molkentin
Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy.
Circulation 2000;101(20):2431-7.
2000: Leon J De Windt; HW Lim; S Haq; Thomas Force; Jeffery D Molkentin
Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways.
The Journal of biological chemistry 2000;275(18):13571-9.
2000: HW Lim; Leon J De Windt; J Mante; Thomas R Kimball; Sandra A Witt; Mark A Sussman; Jeffery D Molkentin
Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.
Journal of molecular and cellular cardiology 2000;32(4):697-709.
2000: Mark A Sussman; Sara Welch; A Walker; Raisa Klevitsky; TE Hewett; Sandra A Witt; T R Kimball; Robert L Price; HW Lim; Jeffery D Molkentin
Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice.
Cardiovascular research 2000;46(1):90-101.
2000: Leon J De Windt; HW Lim; T Taigen; Detlef Wencker; G Condorelli; Gerald W Dorn; Richard N Kitsis; Jeffery D Molkentin
Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure.
Circulation research 2000;86(3):255-63.
2000: T Taigen; Leon J De Windt; HW Lim; Jeffery D Molkentin
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1196-201.
2000: Jeffery D Molkentin; C Antos; B Mercer; T Taigen; J M Miano; E N Olson
Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart.
Developmental biology 2000;217(2):301-9.
2000: Jiahuai Han; Jeffery D Molkentin
Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology.
Trends in cardiovascular medicine 2000;10(1):19-22.
1999: Mark A Sussman; Sara Welch; Natalie Gude; P R Khoury; S R Daniels; D Kirkpatrick; R A Walsh; Robert L Price; HW Lim; Jeffery D Molkentin
Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice.
The American journal of pathology 1999;155(6):2101-13.
1999: Kathleen Gajewski; Nancy Fossett; Jeffery D Molkentin; Robert A Schulz
The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila.
Development (Cambridge, England) 1999;126(24):5679-88.
1999: Eric N Olson; Jeffery D Molkentin
Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?
Circulation research 1999;84(6):623-32.
1999: J Wilson-Rawls; Jeffery D Molkentin; Brian L Black; Eric N Olson
Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C.
Molecular and cellular biology 1999;19(4):2853-62.
1998: Mark A Sussman; HW Lim; Natalie Gude; T Taigen; E N Olson; Jeffrey Robbins; Melissa C Colbert; A Gualberto; D F Wieczorek; Jeffery D Molkentin
Prevention of cardiac hypertrophy in mice by calcineurin inhibition.
Science (New York, N.Y.) 1998;281(5383):1690-3.
1998: Jeffery D Molkentin; Jianhua Lu; Christopher L Antos; B Markham; J Richardson; J Robbins; S R Grant; Eric N Olson
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
Cell 1998;93(2):215-28.
1998: Y Katoh; Jeffery D Molkentin; Vrushank Dave; E N Olson; Muthu Periasamy
MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.
The Journal of biological chemistry 1998;273(3):1511-8.
1998: Brian L Black; Jeffery D Molkentin; Eric N Olson
Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2.
Molecular and cellular biology 1998;18(1):69-77.
1997: T C Herzig; SM Jobe; H Aoki; Jeffery D Molkentin; A W Cowley; Seigo Izumo; Bruce E Markham
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7543-8.
1997: Jeffery D Molkentin; Q Lin; S A Duncan; Eric N Olson
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Genes & development 1997;11(8):1061-72.
1996: Jeffery D Molkentin; E N Olson
Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9366-73.
1996: Jeffery D Molkentin; E N Olson
Defining the regulatory networks for muscle development.
Current opinion in genetics & development 1996;6(4):445-53.
1996: Jeffery D Molkentin; L Li; E N Olson
Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.
The Journal of biological chemistry 1996;271(29):17199-204.
1996: Jeffery D Molkentin; AB Firulli; Brian L Black; J F Martin; C M Hustad; N Copeland; N Jenkins; G Lyons; E N Olson
MEF2B is a potent transactivator expressed in early myogenic lineages.
Molecular and cellular biology 1996;16(7):3814-24.
1996: Jeffery D Molkentin; Brian L Black; J F Martin; E N Olson
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.
Molecular and cellular biology 1996;16(6):2627-36.
1995: Jeffery D Molkentin; Brian L Black; J F Martin; E N Olson
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins.
Cell 1995;83(7):1125-36.
1995: G Ranganayakulu; B Zhao; A Dokidis; Jeffery D Molkentin; E N Olson; Robert A Schulz
A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila.
Developmental biology 1995;171(1):169-81.