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Brian Monks

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Erik C Hett; Tomohiko Kawate; Eicke Latz; Kevin G Mark; Brian G Monks; Louise H Slater; Andrea Stutz; Deborah T Hung
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Joseph Conlon; Numana Bhat; Dara L Burdette; Zhaozhao Jiang; Tengchuan Jin; Brian G Monks; Vijay A K Rathinam; Shruti Sharma; Mikayla Thompson; Russell E Vance; Stefanie N Vogel; T Sam Xiao; Katherine A Fitzgerald
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid.
Eva Bartok; Franz Bauernfeind; Katherine A Fitzgerald; Christopher Jakobs; Maria G Khaminets; Eicke Latz; Brian G Monks; Veit Hornung
iGLuc: a luciferase-based inflammasome and protease activity reporter.

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All Publications

2013: Erik C Hett; Tomohiko Kawate; Eicke Latz; Kevin G Mark; Brian G Monks; Louise H Slater; Andrea Stutz; Deborah T Hung
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Nature chemical biology 2013;9(6):398-405.
2013: Joseph Conlon; Numana Bhat; Dara L Burdette; Zhaozhao Jiang; Tengchuan Jin; Brian G Monks; Vijay A K Rathinam; Shruti Sharma; Mikayla Thompson; Russell E Vance; Stefanie N Vogel; T Sam Xiao; Katherine A Fitzgerald
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):5216-25.
2013: Eva Bartok; Franz Bauernfeind; Katherine A Fitzgerald; Christopher Jakobs; Maria G Khaminets; Eicke Latz; Brian G Monks; Veit Hornung
iGLuc: a luciferase-based inflammasome and protease activity reporter.
Nature methods 2013;10(2):147-54.
2011: Jutamas Shaughnessy; Connie Tran; Alberto Visintin; Arnab Bhattacharjee; Gabor Horvath; T. Sakari Jokiranta; Brian G Monks; Joana Pedrosa; Sanjay Ram; Peter A Rice
Molecular characterization of the interaction between sialylated Neisseria gonorrhoeae and factor H.
The Journal of biological chemistry 2011;286(25):22235-42.
2011: Kamalpreet Nagpal; Theo S Plantinga; Cherilyn M Sirois; Brian G Monks; Eicke Latz; Mihai G Netea; Douglas T Golenbock
Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.
The Journal of biological chemistry 2011;286(13):11875-82.
2010: Jianmin Meng; Joshua R Drolet; Brian G Monks; Douglas T Golenbock
MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.
The Journal of biological chemistry 2010;285(36):27935-43.
2010: Vijay A K Rathinam; Zhaozhao Jiang; Stephen N Waggoner; Shruti Sharma; Leah E Cole; Lisa Waggoner; Sivapriya Kailasan Vanaja; Brian G Monks; Sandhya Ganesan; Eicke Latz; Veit Hornung; Stefanie N Vogel; Eva Szomolanyi-Tsuda; Katherine A Fitzgerald
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Nature immunology 2010;11(5):395-402.
2010: Nadege Goutagny; Zhaozhao Jiang; Jane Tian; Peggy Parroche; Jeanne H Schickli; Brian G Monks; Nancy D Ulbrandt; Hong Ji; Peter Kiener; Anthony J Coyle; Katherine A Fitzgerald
Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1168-79.
2009: Kamalpreet Nagpal; Theo S Plantinga; Joyce Wong; Brian G Monks; nicholas gay; Mihai G Netea; Katherine A Fitzgerald; Douglas T Golenbock
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
The Journal of biological chemistry 2009;284(38):25742-8.
2009: Franz G Bauernfeind; Gabor Horvath; Andrea Stutz; Emad S Alnemri; Kelly MacDonald; David Speert; Teresa Fernandes-Alnemri; Jianghong Wu; Brian G Monks; Katherine A Fitzgerald; Veit Hornung; Eicke Latz
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):787-91.
2008: Annett Halle; Veit Hornung; Gabor C Petzold; Cameron R Stewart; Brian G Monks; Thomas Reinheckel; Katherine A Fitzgerald; Eicke Latz; Kathryn J Moore; Douglas T Golenbock
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Nature immunology 2008;9(8):857-65.
2008: Jutamas Ngampasutadol; Sanjay Ram; Sunita Gulati; Sarika Agarwal; Chongqing Li; Alberto Visintin; Brian G Monks; Guillermo Madico; Peter A Rice
Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasion.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3426-35.
2007: Eicke Latz; Anjali Verma; Alberto Visintin; Mei Gong; Cherilyn M Sirois; David C Klein; Brian G Monks; C James McKnight; Marc S Lamphier; W Paul Duprex; Terje Espevik; Douglas T Golenbock
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Nature immunology 2007;8(7):772-9.
2007: Peggy Parroche; Fanny N Lauw; Nadege Goutagny; Eicke Latz; Brian G Monks; Alberto Visintin; Kristen A Halmen; Marc S Lamphier; Martin Olivier; Daniella C Bartholomeu; Ricardo T Gazzinelli; Douglas T Golenbock
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1919-24.
2006: Alberto Visintin; Kristen A Halmen; Naseema Khan; Brian G Monks; Douglas T Golenbock; Egil Lien
MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).
Journal of leukocyte biology 2006;80(6):1584-92.
2006: Daniel Rowe; Anne F McGettrick; Eicke Latz; Brian G Monks; nicholas gay; Masahiro Yamamoto; Shizuo Akira; Luke A J O'Neill; Katherine A Fitzgerald; Douglas T Golenbock
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6299-304.
2006: Alberto Visintin; Dimitar B Iliev; Brian G Monks; Kristen A Halmen; Douglas T Golenbock
MD-2.
Immunobiology 2006;211(6-8):437-47.
2005: Alberto Visintin; Kristen A Halmen; Eicke Latz; Brian G Monks; Douglas T Golenbock
Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6465-72.
2005: Simon Rothenfusser; Nadege Goutagny; Gary DiPerna; Mei Gong; Brian G Monks; Annett Schoenemeyer; Masahiro Yamamoto; Shizuo Akira; Katherine A Fitzgerald
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5260-8.
2004: Eicke Latz; Annett Schoenemeyer; Alberto Visintin; Katherine A Fitzgerald; Brian G Monks; Cathrine F Knetter; Egil Lien; Nadra Nilsen; Terje Espevik; Douglas T Golenbock
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature immunology 2004;5(2):190-8.
2003: Alberto Visintin; Eicke Latz; Brian G Monks; Terje Espevik; Douglas T Golenbock
Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
The Journal of biological chemistry 2003;278(48):48313-20.
2003: Katherine A Fitzgerald; Daniel Rowe; Betsy J Barnes; Daniel R Caffrey; Alberto Visintin; Eicke Latz; Brian G Monks; PAULA PITHA-ROWE; Douglas T Golenbock
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
The Journal of experimental medicine 2003;198(7):1043-55.
2003: Terje Espevik; Eicke Latz; Egil Lien; Brian G Monks; Douglas T Golenbock
Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
Scandinavian journal of infectious diseases 2003;35(9):660-4.
2002: Eicke Latz; Alberto Visintin; Egil Lien; Katherine A Fitzgerald; Brian G Monks; Evelyn A Kurt-Jones; Douglas T Golenbock; Terje Espevik
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
The Journal of biological chemistry 2002;277(49):47834-43.
2002: Trude H Flo; Liv Ryan; Eicke Latz; Osamu Takeuchi; Brian G Monks; Egil Lien; Øyvind Halaas; Shizuo Akira; Gudmund Skjåk-Braek; Douglas T Golenbock; Terje Espevik
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
The Journal of biological chemistry 2002;277(38):35489-95.
2001: Andra B Schromm; Egil Lien; Philipp Henneke; J C Chow; A Yoshimura; Holger Heine; Eicke Latz; Brian G Monks; D A Schwartz; K Miyake; Douglas T Golenbock
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
The Journal of experimental medicine 2001;194(1):79-88.
2000: Kathryn J Moore; Lorna P Andersson; Robin R Ingalls; Brian G Monks; R Li; M Amin Arnaout; Douglas T Golenbock; Mason W Freeman
Divergent response to LPS and bacteria in CD14-deficient murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4272-80.
2000: Egil Lien; TK Means; Holger Heine; A Yoshimura; Shoichi Kusumoto; Koichi Fukase; Matthew J Fenton; Masato Oikawa; N Qureshi; Brian G Monks; R W Finberg; Robin R Ingalls; Douglas T Golenbock
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
The Journal of clinical investigation 2000;105(4):497-504.
1999: Holger Heine; RL Delude; Brian G Monks; Terje Espevik; Douglas T Golenbock
Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.
The Journal of biological chemistry 1999;274(30):21049-55.
1999: Holger Heine; C J Kirschning; Egil Lien; Brian G Monks; M Rothe; Douglas T Golenbock
Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):6971-5.
1999: Robin R Ingalls; Brian G Monks; Douglas T Golenbock
Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14.
The Journal of biological chemistry 1999;274(20):13993-8.
1998: Robin R Ingalls; Brian G Monks; R Savedra; W J Christ; RL Delude; Andrei E Medvedev; Terje Espevik; Douglas T Golenbock
CD11/CD18 and CD14 share a common lipid A signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5413-20.
1997: M M Wurfel; Brian G Monks; Robin R Ingalls; R L Dedrick; RL Delude; D Zhou; Norbert Lamping; Ralf R Schumann; Rolf Thieringer; Matthew J Fenton; Samuel D Wright; Douglas T Golenbock
Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.
The Journal of experimental medicine 1997;186(12):2051-6.
1994: J A Buras; Brian G Monks; Matthew J Fenton
The NF-beta A-binding element, not an overlapping NF-IL-6-binding element, is required for maximal IL-1 beta gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4444-54.
1994: Brian G Monks; B A Martell; J A Buras; Matthew J Fenton
An upstream protein interacts with a distinct protein that binds to the cap site of the human interleukin 1 beta gene.
Molecular immunology 1994;31(2):139-51.
1992: Gary W Hunninghake; Brian G Monks; LJ Geist; Martha M Monick; M. Alexandra Monroy; Mark F Stinski; A C Webb; J M Dayer; Philip E. auron; Matthew J Fenton
The functional importance of a cap site-proximal region of the human prointerleukin 1 beta gene is defined by viral protein trans-activation.
Molecular and cellular biology 1992;12(8):3439-48.