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William Montfort

Research Profile

Concepts & Ideas

Procedures

X Ray Crystallography

Chemicals & Drugs

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Escherichia coli

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Genes & Molecular Sequences

Amino Acid Sequences

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TOP 3
Yuquan Xu; Jia Zeng; Jixun Zhan; Wei Zhang; Tong Zhou; Zhengfu Zhou; Ming Chen; Min Lin; William R Montfort; Sue A Roberts; Shiyou Su; István Molnár
Rational reprogramming of fungal polyketide first-ring cyclization.
Bradley G. Fritz; Wenzhou Li; Aqeel Ahmed; Jacqueline L Brailey; Linda Breci; Sue A Roberts; Florence Tama; Andrzej Weichsel; Vicki H Wysocki; William R Montfort
Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking.
Satish K Singh; Andrzej Weichsel; Guenter F Wildner; Gregor B Grass; Sylvia F McDevitt; Christopher Rensing; Sue A Roberts; William R Montfort
Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence.

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2013: Yuquan Xu; Jia Zeng; Jixun Zhan; Wei Zhang; Tong Zhou; Zhengfu Zhou; Ming Chen; Min Lin; William R Montfort; Sue A Roberts; Shiyou Su; István Molnár
Rational reprogramming of fungal polyketide first-ring cyclization.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5398-403.
2013: Bradley G. Fritz; Wenzhou Li; Aqeel Ahmed; Jacqueline L Brailey; Linda Breci; Sue A Roberts; Florence Tama; Andrzej Weichsel; Vicki H Wysocki; William R Montfort
Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking.
Biochemistry 2013;52(9):1568-82.
2011: Satish K Singh; Andrzej Weichsel; Guenter F Wildner; Gregor B Grass; Sylvia F McDevitt; Christopher Rensing; Sue A Roberts; William R Montfort
Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence.
The Journal of biological chemistry 2011;286(43):37849-57.
2011: Saumya Ramanathan; Scott Boitano; Stacy Mazzalupo; William R Montfort
Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration.
Biochemistry 2011;50(36):7787-99.
2011: Bradley G. Fritz; Xiaohui Hu; Robert E Berry; Jacqueline L Brailey; F Ann Walker; William R Montfort
Oxidation and loss of heme in soluble guanylyl cyclase from Manduca sexta.
Biochemistry 2011;50(26):5813-5.
2010: Andrzej Weichsel; Michelle Kem; William R Montfort
Crystal structure of human thioredoxin revealing an unraveled helix and exposed S-nitrosation site.
Protein science : a publication of the Protein Society 2010;19(9):1801-6.
2010: Abdelkrim BENABBAS; Xiong Ye; Minoru Kubo; Zhenyu Zhang; Estelle M Maes; William R Montfort; Paul M Champion
Ultrafast dynamics of diatomic ligand binding to nitrophorin 4.
Journal of the American Chemical Society 2010;132(8):2811-20.
2009: Zachary T Campbell; Andrzej Weichsel; William R Montfort; Thomas O Baldwin
Crystal structure of the bacterial luciferase/flavin complex provides insight into the function of the beta subunit.
Biochemistry 2009;48(26):6085-94.
2009: Thomas S Dexheimer; Steven S Carey; Song Zuohe; Vijay Gokhale; Xiaohui Hu; Lauren B Murata; Estelle M Maes; Andrzej Weichsel; Daekyu Sun; Emmanuelle J Meuillet; William R Montfort; Laurence H Hurley
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).
Molecular cancer therapeutics 2009;8(5):1363-77.
2009: Robert E Berry; Maxim N Shokhirev; Arthur Y W Ho; Fei Yang; Tatjana K Shokhireva; Hongjun Zhang; Andrzej Weichsel; William R Montfort; F Ann Walker
Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes.
Journal of the American Chemical Society 2009;131(6):2313-27.
2008: Xiaohui Hu; Lauren B Murata; Andrzej Weichsel; Jacqueline L Brailey; Sue A Roberts; Alan Nighorn; William R Montfort
Allostery in recombinant soluble guanylyl cyclase from Manduca sexta.
The Journal of biological chemistry 2008;283(30):20968-77.
2008: Matthew S Dubrava; Wendy M Ingram; Sue A Roberts; Andrzej Weichsel; William R Montfort; Matthew H J Cordes
N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces.
Protein science : a publication of the Protein Society 2008;17(5):803-12.
2008: Christian G Roessler; Branwen Hall; William J Anderson; Wendy M Ingram; Sue A Roberts; William R Montfort; Matthew H J Cordes
Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2343-8.
2008: Shane D Morrison; Sue A Roberts; Abreeza M Zegeer; William R Montfort; Vahe Bandarian
A new use for a familiar fold: the X-ray crystal structure of GTP-bound GTP cyclohydrolase III from Methanocaldococcus jannaschii reveals a two metal ion catalytic mechanism.
Biochemistry 2008;47(1):230-42.
2007: Gabrielle D Malo; Lauren J Pouwels; Meitian Wang; Andrzej Weichsel; William R Montfort; Mark A Rizzo; David W Piston; Rebekka M Wachter
X-ray structure of Cerulean GFP: a tryptophan-based chromophore useful for fluorescence lifetime imaging.
Biochemistry 2007;46(35):9865-73.
2007: Angela M Amoia; William R Montfort
Apo-nitrophorin 4 at atomic resolution.
Protein science : a publication of the Protein Society 2007;16(9):2076-81.
2007: Dmitry A Kondrashov; William R Montfort
Nonequilibrium dynamics simulations of nitric oxide release: comparative study of nitrophorin and myoglobin.
The journal of physical chemistry. B 2007;111(31):9244-52.
2007: Eric Schreiter; María M Rodríguez; Andrzej Weichsel; William R Montfort; Joseph Bonaventura
S-nitrosylation-induced conformational change in blackfin tuna myoglobin.
The Journal of biological chemistry 2007;282(27):19773-80.
2007: Tatjana Kh Shokhireva; Andrzej Weichsel; Kevin M Smith; Robert E Berry; Nikolai V Shokhirev; Celia A Balfour; Hongjun Zhang; William R Montfort; F Ann Walker
Assignment of the ferriheme resonances of the low-spin complexes of nitrophorins 1 and 4 by (1)H and (13)C NMR spectroscopy: comparison to structural data obtained from X-ray crystallography.
Inorganic chemistry 2007;46(6):2041-56.
2007: Andrzej Weichsel; Jacqueline L Brailey; William R Montfort
Buried S-nitrosocysteine revealed in crystal structures of human thioredoxin.
Biochemistry 2007;46(5):1219-27.
2006: Sue A Roberts; David C Hyatt; Jerry E Honts; Liming Changchien; Gladys F Maley; Frank Maley; William R Montfort
Structure of the Y94F mutant of Escherichia coli thymidylate synthase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 9):840-3.
2006: Rogerio Sotelo-Mundo; Liming Changchien; Frank Maley; William R Montfort
Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
Journal of biochemical and molecular toxicology 2006;20(2):88-92.
2005: Estelle M Maes; Sue A Roberts; Andrzej Weichsel; William R Montfort
Ultrahigh resolution structures of nitrophorin 4: heme distortion in ferrous CO and NO complexes.
Biochemistry 2005;44(38):12690-9.
2005: Isabell R Loftin; Sylvia Franke; Sue A Roberts; Andrzej Weichsel; Annie Héroux; William R Montfort; Christopher Rensing; Megan M McEvoy
A novel copper-binding fold for the periplasmic copper resistance protein CusF.
Biochemistry 2005;44(31):10533-40.
2005: Andrzej Weichsel; Estelle M Maes; John F Andersen; Jesus G Valenzuela; Tatjana Kh Shokhireva; F Ann Walker; William R Montfort
Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):594-9.
2004: Dmitry A Kondrashov; Sue A Roberts; Andrzej Weichsel; William R Montfort
Protein functional cycle viewed at atomic resolution: conformational change and mobility in nitrophorin 4 as a function of pH and NO binding.
Biochemistry 2004;43(43):13637-47.
2004: Satish K Singh; Gregor Grass; Christopher Rensing; William R Montfort
Cuprous oxidase activity of CueO from Escherichia coli.
Journal of bacteriology 2004;186(22):7815-7.
2004: Karin Nienhaus; Estelle M Maes; Andrzej Weichsel; William R Montfort; G Ulrich Nienhaus
Structural dynamics controls nitric oxide affinity in nitrophorin 4.
The Journal of biological chemistry 2004;279(38):39401-7.
2004: Estelle M Maes; Andrzej Weichsel; John F Andersen; Donald Shepley; William R Montfort
Role of binding site loops in controlling nitric oxide release: structure and kinetics of mutant forms of nitrophorin 4.
Biochemistry 2004;43(21):6679-90.
2004: Robert E Berry; Xiao D Ding; Tatjana Kh Shokhireva; Andrzej Weichsel; William R Montfort; F Ann Walker
Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(2):135-44.
2003: Sue A Roberts; Günter F Wildner; Gregor Grass; Andrzej Weichsel; Attila Ambrus; Christopher Rensing; William R Montfort
A labile regulatory copper ion lies near the T1 copper site in the multicopper oxidase CueO.
The Journal of biological chemistry 2003;278(34):31958-63.
2002: Sue A Roberts; Andrzej Weichsel; Gregor Grass; Keshari Thakali; James T Hazzard; Gordon Tollin; Christopher Rensing; William R Montfort
Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2766-71.
2001: Estelle M Maes; F Ann Walker; William R Montfort; Roman S Czernuszewicz
Resonance Raman spectroscopic study of nitrophorin 1, a nitric oxide-binding heme protein from Rhodnius prolixus, and its nitrosyl and cyano adducts.
Journal of the American Chemical Society 2001;123(47):11664-72.
2001: Sue A Roberts; Andrzej Weichsel; Y Qiu; J A Shelnutt; F Ann Walker; William R Montfort
Ligand-induced heme ruffling and bent no geometry in ultra-high-resolution structures of nitrophorin 4.
Biochemistry 2001;40(38):11327-37.
2001: Garth Powis; William R Montfort
Properties and biological activities of thioredoxins.
Annual review of biophysics and biomolecular structure 2001;30():421-55.
2001: Garth Powis; William R Montfort
Properties and biological activities of thioredoxins.
Annual review of pharmacology and toxicology 2001;41():261-95.
2000: William R Montfort; Andrzej Weichsel; John F Andersen
Nitrophorins and related antihemostatic lipocalins from Rhodnius prolixus and other blood-sucking arthropods.
Biochimica et biophysica acta 2000;1482(1-2):110-8.
2000: John F Andersen; William R Montfort
The crystal structure of nitrophorin 2. A trifunctional antihemostatic protein from the saliva of Rhodnius prolixus.
The Journal of biological chemistry 2000;275(39):30496-503.
2000: John F Andersen; X D Ding; Celia A Balfour; Tatjana K Shokhireva; DE Champagne; F Ann Walker; William R Montfort
Kinetics and equilibria in ligand binding by nitrophorins 1-4: evidence for stabilization of a nitric oxide-ferriheme complex through a ligand-induced conformational trap.
Biochemistry 2000;39(33):10118-31.
2000: Andrzej Weichsel; John F Andersen; Sue A Roberts; William R Montfort
Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial.
Nature structural biology 2000;7(7):551-4.
2000: Zeina E Jouni; J Zamora; M Snyder; William R Montfort; Andrzej Weichsel; Michael A Wells
alpha-cyclodextrin extracts diacylglycerol from insect high density lipoproteins.
Journal of lipid research 2000;41(6):933-9.
1999: Rogerio Sotelo-Mundo; Joanna Ciesla; Jolanta M Dzik; Wojciech Rode; Frank Maley; Gladys F Maley; L W Hardy; William R Montfort
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Biochemistry 1999;38(3):1087-94.
1999: F Ann Walker; JM Ribeiro; William R Montfort
Novel nitric oxide-liberating heme proteins from the saliva of bloodsucking insects.
Metal ions in biological systems 1999;36():621-63.
1998: John F Andersen; Andrzej Weichsel; Celia A Balfour; DE Champagne; William R Montfort
The crystal structure of nitrophorin 4 at 1.5 A resolution: transport of nitric oxide by a lipocalin-based heme protein.
Structure (London, England : 1993) 1998;6(10):1315-27.
1998: Andrzej Weichsel; John F Andersen; DE Champagne; F Ann Walker; William R Montfort
Crystal structures of a nitric oxide transport protein from a blood-sucking insect.
Nature structural biology 1998;5(4):304-9.
1998: A P Lobo; M G Nair; Liming Changchien; Andrzej Weichsel; William R Montfort; Frank Maley
Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase.
Biochemistry 1998;37(13):4535-42.
1997: Pavel Strop; Liming Changchien; Frank Maley; William R Montfort
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Protein science : a publication of the Protein Society 1997;6(12):2504-11.
1997: John F Andersen; D A Sanders; JR Gasdaska; Andrzej Weichsel; Garth Powis; William R Montfort
Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant.
Biochemistry 1997;36(46):13979-88.
1997: William R Montfort; Andrzej Weichsel
Thymidylate synthase: structure, inhibition, and strained conformations during catalysis.
Pharmacology & therapeutics 1997;76(1-3):29-43.
1997: D C Hyatt; Frank Maley; William R Montfort
Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Biochemistry 1997;36(15):4585-94.
1997: John F Andersen; DE Champagne; Andrzej Weichsel; JM Ribeiro; Celia A Balfour; V Dress; William R Montfort
Nitric oxide binding and crystallization of recombinant nitrophorin I, a nitric oxide transport protein from the blood-sucking bug Rhodnius prolixus.
Biochemistry 1997;36(15):4423-8.
1996: JR Gasdaska; D Lynn Kirkpatrick; William R Montfort; M Kuperus; S R Hill; Margareta I Berggren; Garth Powis
Oxidative inactivation of thioredoxin as a cellular growth factor and protection by a Cys73-->Ser mutation.
Biochemical pharmacology 1996;52(11):1741-7.
1996: Andrzej Weichsel; JR Gasdaska; Garth Powis; William R Montfort
Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer.
Structure (London, England : 1993) 1996;4(6):735-51.
1995: Andrzej Weichsel; William R Montfort
Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89.
Nature structural biology 1995;2(12):1095-101.
1995: Andrzej Weichsel; William R Montfort; J Cieśla; Frank Maley
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3493-7.
1995: D M Voeller; Liming Changchien; Gladys F Maley; Frank Maley; T Takechi; R E Turner; William R Montfort; Carmen J Allegra; Edward Chu
Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.
Nucleic acids research 1995;23(5):869-75.
1994: Janet S Finer-Moore; Gladys F Maley; Frank Maley; William R Montfort; Robert M Stroud
Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.
Biochemistry 1994;33(51):15459-68.
1990: Janet S Finer-Moore; William R Montfort; Robert M Stroud
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase.
Biochemistry 1990;29(30):6977-86.
1990: William R Montfort; K M Perry; E B Fauman; Janet S Finer-Moore; Gladys F Maley; L Hardy; Frank Maley; Robert M Stroud
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Biochemistry 1990;29(30):6964-77.
1990: K M Perry; E B Fauman; Janet S Finer-Moore; William R Montfort; Gladys F Maley; Frank Maley; Robert M Stroud
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
Proteins 1990;8(4):315-33.
1987: L W Hardy; Janet S Finer-Moore; William R Montfort; M O Jones; Daniel V Santi; Robert M Stroud
Atomic structure of thymidylate synthase: target for rational drug design.
Science (New York, N.Y.) 1987;235(4787):448-55.