FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Darren Moore

Research Profile

Disorders

Parkinson's Disease

Chemicals & Drugs

Physiology

Anatomy

Co-author Network

Publications

TOP 3
Alice Biosa; Luigi Bubacco; Laura Civiero; Liliane Glauser; Elisa Greggio; Alzbeta Trancikova; Darren J Moore
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Elpida Tsika; Darren J Moore
Mechanisms of LRRK2-mediated neurodegeneration.
João Paulo L Daher; Ted M Dawson; Valina Dawson; Dagmar Galter; Sandra Gellhaar; Michael K Lee; Alessandra Musso; Olga Pletnikova; Juan C Troncoso; Saskia Biskup; Darren J Moore
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Darren Moore (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Alice Biosa; Luigi Bubacco; Laura Civiero; Liliane Glauser; Elisa Greggio; Alzbeta Trancikova; Darren J Moore
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Human molecular genetics 2013;22(6):1140-56.
2012: Elpida Tsika; Darren J Moore
Mechanisms of LRRK2-mediated neurodegeneration.
Current neurology and neuroscience reports 2012;12(3):251-60.
2012: João Paulo L Daher; Ted M Dawson; Valina Dawson; Dagmar Galter; Sandra Gellhaar; Michael K Lee; Alessandra Musso; Olga Pletnikova; Juan C Troncoso; Saskia Biskup; Darren J Moore
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Human molecular genetics 2012;21(11):2420-31.
2012: Bruno Fauvet; Patrick Aebischer; Mustafa T Ardah; Philippe Coune; Carole Desobry; Omar M A El-Agnaf; David Eliezer; Mohamed-Bilal Fares; Niels Lion; Eliezer Masliah; Martial K Mbefo; Sarah Michael; Darren J Moore; Michel Prudent; Bernard Schneider; Elpida Tsika; Hilal A Lashuel
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
The Journal of biological chemistry 2012;287(19):15345-64.
2012: Alzbeta Trancikova; Elpida Tsika; Darren J Moore
Mitochondrial dysfunction in genetic animal models of Parkinson's disease.
Antioxidants & redox signaling 2012;16(9):896-919.
2012: David Ramonet; Sarah Sonnay; Klodjan Stafa; Alzbeta Trancikova; Juan C Troncoso; Elpida Tsika; Liliane Glauser; Olga Pletnikova; Agata Podhajska; Darren J Moore
PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity.
Human molecular genetics 2012;21(8):1725-43.
2012: Alzbeta Trancikova; Elpida Tsika; Philip J Webber; Andrew B West; Rina Bandopadhyay; Liliane Glauser; Adamantios Mamais; Klodjan Stafa; Darren J Moore
Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
PloS one 2012;7(10):e47784.
2012: Agata Podhajska; Sarah Sonnay; Klodjan Stafa; Alzbeta Trancikova; Liliane Glauser; Roger Moser; Alessandra Musso; Darren J Moore
Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonism.
PloS one 2012;7(6):e39942.
2012: Klodjan Stafa; Alzbeta Trancikova; Philip J Webber; Andrew B West; Liliane Glauser; Darren J Moore
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.
PLoS genetics 2012;8(2):e1002526.
2011: Nada A Abumrad; Darren J Moore
Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36.
The Journal of clinical investigation 2011;121(9):3389-92.
2011: Liliane Glauser; Sarah Sonnay; Klodjan Stafa; Darren J Moore
Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.
Journal of neurochemistry 2011;118(4):636-45.
2011: Shinji Higashi; Darren J Moore; Michiko Minegishi; Koji Kasanuki; Hiroshige Fujishiro; Tomohiro Kabuta; Takashi Togo; Omi Katsuse; Hirotake Uchikado; Yoshiko Furukawa; Hiroaki Hino; Kenji Kosaka; Kiyoshi Sato; Heii Arai; Keiji Wada; Eizo Iseki
Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.
Journal of neuropathology and experimental neurology 2011;70(4):264-80.
2011: Julien Dusonchet; Olexiy Kochubey; Klodjan Stafa; Samuel M Young; Romain Zufferey; Darren J Moore; Bernard L Schneider; Patrick Aebischer
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(3):907-12.
2011: David Ramonet; João Paulo L Daher; Brian M Lin; Klodjan Stafa; Jaekwang Kim; Rebecca Banerjee; Marie Westerlund; Olga Pletnikova; Liliane Glauser; Lichuan Yang; Ying Liu; Deborah A Swing; M Flint Beal; Juan C Troncoso; J Michael McCaffery; Nancy A Jenkins; Neal G Copeland; Dagmar Galter; Bobby Thomas; Michael K Lee; Ted M Dawson; Valina Dawson; Darren J Moore
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
PloS one 2011;6(4):e18568.
2011: Alzbeta Trancikova; David Ramonet; Darren J Moore
Genetic mouse models of neurodegenerative diseases.
Progress in molecular biology and translational science 2011;100():419-82.
2010: Xiaojie Li; Darren J Moore; Yulan Xiong; Ted M Dawson; Valina Dawson
Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2.
The Journal of biological chemistry 2010;285(38):29569-76.
2010: Yulan Xiong; Candice E Coombes; Austin Kilaru; Xiaojie Li; Aaron D Gitler; William J Bowers; Valina Dawson; Ted M Dawson; Darren J Moore
GTPase activity plays a key role in the pathobiology of LRRK2.
PLoS genetics 2010;6(4):e1000902.
2010: Cristofol Vives-Bauza; Chun Zhou; Yong Huang; Mei Cui; Rosa L A de Vries; Jiho Kim; Jessica May; Maja Aleksandra Tocilescu; Wencheng Liu; Han Seok Ko; Jordi Magrané; Darren J Moore; Valina Dawson; Regis Grailhe; Ted M Dawson; Chenjian Li; Kim Tieu; Serge Przedborski
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):378-83.
2009: Shinji Higashi; Darren J Moore; Ryoko Yamamoto; Michiko Minegishi; Kiyoshi Sato; Takashi Togo; Omi Katsuse; Hirotake Uchikado; Yoshiko Furukawa; Hiroaki Hino; Kenji Kosaka; Piers C Emson; Keiji Wada; Valina Dawson; Ted M Dawson; Heii Arai; Eizo Iseki
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Journal of neuropathology and experimental neurology 2009;68(9):994-1005.
2009: Ted M Dawson; Darren J Moore; Andrew B West
Revelations and revolutions in the understanding of Parkinson's disease.
Biochimica et biophysica acta 2009;1792(7):585-6.
2009: Han Seok Ko; Rachel Bailey; Wanli Smith; Zhaohui Liu; Joo-Ho Shin; Yun-Il Lee; Yong-Jie Zhang; Haibing Jiang; Christopher A Ross; Darren J Moore; Winston Patterson; Leonard Petrucelli; Ted M Dawson; Valina Dawson
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2897-902.
2009: João Paulo L Daher; Mingyao Ying; Rebecca Banerjee; Rebecca S McDonald; Myriam Dumas Hahn; Lichuan Yang; M Flint Beal; Bobby Thomas; Valina Dawson; Ted M Dawson; Darren J Moore
Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons.
Molecular neurodegeneration 2009;4():34.
2008: Darren J Moore; Ted M Dawson
Value of genetic models in understanding the cause and mechanisms of Parkinson's disease.
Current neurology and neuroscience reports 2008;8(4):288-96.
2008: Darren J Moore; Andrew B West; Dustin A Dikeman; Valina Dawson; Ted M Dawson
Parkin mediates the degradation-independent ubiquitination of Hsp70.
Journal of neurochemistry 2008;105(5):1806-19.
2008: Lizhen Wang; Chengsong Xie; Elisa Greggio; Loukia Parisiadou; Hoon Shim; Lixin Sun; Jayanth Chandran; Xian Lin; Chen Lai; Wan-Jou Yang; Darren J Moore; Ted M Dawson; Valina Dawson; Gabriela Chiosis; Mark Cookson; Huaibin Cai
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(13):3384-91.
2008: Darren J Moore
The biology and pathobiology of LRRK2: implications for Parkinson's disease.
Parkinsonism & related disorders 2008;14 Suppl 2():S92-8.
2007: Shinji Higashi; Saskia Biskup; Andrew B West; Daniel Trinkaus; Valina Dawson; Richard L M Faull; Henry J Waldvogel; Heii Arai; Ted M Dawson; Darren J Moore; Piers C Emson
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.
Brain research 2007;1155():208-19.
2007: Andrew B West; Darren J Moore; Catherine Choi; Shaida A Andrabi; Xiaojie Li; Dustin Dikeman; Saskia Biskup; Zhenshui Zhang; Kah Leong Lim; Valina Dawson; Ted M Dawson
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.
Human molecular genetics 2007;16(2):223-32.
2007: Saskia Biskup; Darren J Moore; Alexis Rea; Bettina Lorenz-Deperieux; Candice E Coombes; Valina Dawson; Ted M Dawson; Andrew B West
Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
BMC neuroscience 2007;8():102.
2007: Shinji Higashi; Darren J Moore; Rebecca E Colebrooke; Saskia Biskup; Valina Dawson; Heii Arai; Ted M Dawson; Piers C Emson
Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.
Journal of neurochemistry 2007;100(2):368-81.
2006: Saskia Biskup; Darren J Moore; Fulvio Celsi; Shinji Higashi; Andrew B West; Shaida A Andrabi; Kaisa Kurkinen; Seong-Woon Yu; Joseph M Savitt; Henry J Waldvogel; Richard L M Faull; Piers C Emson; Reidun Torp; Ole Petter Ottersen; Ted M Dawson; Valina Dawson
Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Annals of neurology 2006;60(5):557-69.
2006: Darren J Moore
Parkin: a multifaceted ubiquitin ligase.
Biochemical Society transactions 2006;34(Pt 5):749-53.
2006: Saskia Biskup; Darren J Moore
Detrimental deletions: mitochondria, aging and Parkinson's disease.
BioEssays : news and reviews in molecular, cellular and developmental biology 2006;28(10):963-7.
2006: Darren J Moore; Valina Dawson; Ted M Dawson
Lessons from Drosophila models of DJ-1 deficiency.
Science of aging knowledge environment : SAGE KE 2006;2006(2):pe2.
2005: Wanli Smith; Zhong Pei; Haibing Jiang; Darren J Moore; Yideng Liang; Andrew B West; Valina Dawson; Ted M Dawson; Christopher A Ross
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18676-81.
2005: Andrew B West; Darren J Moore; Saskia Biskup; Artem Bugayenko; Wanli Smith; Christopher A Ross; Valina Dawson; Ted M Dawson
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16842-7.
2005: Li Zhang; Mika Shimoji; Bobby Thomas; Darren J Moore; Seong-Woon Yu; Neena I Marupudi; Reidun Torp; Ingeborg A Torgner; Ole Petter Ottersen; Ted M Dawson; Valina Dawson
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis.
Human molecular genetics 2005;14(14):2063-73.
2005: Darren J Moore; Andrew B West; Valina Dawson; Ted M Dawson
Molecular pathophysiology of Parkinson's disease.
Annual review of neuroscience 2005;28():57-87.
2005: Darren J Moore; Li Zhang; Juan C Troncoso; Michael K Lee; Nobutaka Hattori; Yoshikuni Mizuno; Ted M Dawson; Valina Dawson
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.
Human molecular genetics 2005;14(1):71-84.
2003: Darren J Moore; Li Zhang; Ted M Dawson; Valina Dawson
A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.
Journal of neurochemistry 2003;87(6):1558-67.
2003: Darren J Moore; Paul R Murdock; Jeannette M Watson; Richard L M Faull; Henry J Waldvogel; Philip G Szekeres; Shelagh Wilson; Katie B Freeman; Piers C Emson
GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.
Brain research. Molecular brain research 2003;118(1-2):10-23.
2003: Darren J Moore; Valina Dawson; Ted M Dawson
Genetics of Parkinson's disease: what do mutations in DJ-1 tell us?
Annals of neurology 2003;54(3):281-2.
2003: Darren J Moore; Valina Dawson; Ted M Dawson
Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses.
Neuromolecular medicine 2003;4(1-2):95-108.
2002: Darren J Moore; Jon K Chambers; Paul R Murdock; Piers C Emson
Human Ntera-2/D1 neuronal progenitor cells endogenously express a functional P2Y1 receptor.
Neuropharmacology 2002;43(6):966-78.
2001: K Freeman; Ping Tsui; Darren J Moore; P C Emson; L Vawter; S Naheed; P Lane; H Bawagan; Nicole C Herrity; K Murphy; Henry M Sarau; Robert S Ames; Shelagh Wilson; George P Livi; Jon K Chambers
Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Genomics 2001;78(3):124-8.
2001: Darren J Moore; Jon K Chambers; J P Wahlin; K B Tan; Gary B T Moore; O Jenkins; Piers C Emson; Paul R Murdock
Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.
Biochimica et biophysica acta 2001;1521(1-3):107-19.
2001: Alison I Muir; L Chamberlain; Nabil A Elshourbagy; David Michalovich; Darren J Moore; A Calamari; Philip G Szekeres; Henry M Sarau; Jon K Chambers; Paul R Murdock; Klaudia Steplewski; Usman Shabon; JE Miller; S E Middleton; J G Darker; C G Larminie; Shelagh Wilson; DJ Bergsma; Piers C Emson; R Faull; KL Philpott; David C Harrison
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.
The Journal of biological chemistry 2001;276(31):28969-75.
2000: Darren J Moore; Shuji Iritani; J Chambers; Piers C Emson
Immunohistochemical localization of the P2Y1 purinergic receptor in Alzheimer's disease.
Neuroreport 2000;11(17):3799-803.
2000: Darren J Moore; J Chambers; HJ Waldvogel; R Faull; Piers C Emson
Regional and cellular distribution of the P2Y(1) purinergic receptor in the human brain: striking neuronal localisation.
The Journal of comparative neurology 2000;421(3):374-84.