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Kathryn Moore

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Kim Wilkinson; Justin D Boyd; Marcie A Glicksman; Kathryn J Moore; Joseph B El-Khoury
A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.
W K Eddie Ip; Anna Sokolovska; Guillaume M Charriere; Laurent Boyer; Stephanie Dejardin; Michael P Cappillino; L Michael Yantosca; Kazue Takahashi; Kathryn J Moore; Adam Lacy-Hulbert; Lynda M Stuart
Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.
Cameron R Stewart; Lynda M Stuart; Kim Wilkinson; Janine M van Gils; Jiusheng Deng; Annett Halle; Katey J Rayner; Laurent Boyer; Ruiqin Zhong; William A Frazier; Adam Lacy-Hulbert; Joseph B El-Khoury; Douglas T Golenbock; Kathryn J Moore
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

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All Publications

2011: Kim Wilkinson; Justin D Boyd; Marcie A Glicksman; Kathryn J Moore; Joseph B El-Khoury
A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.
The Journal of biological chemistry 2011;286(40):34914-22.
2010: W K Eddie Ip; Anna Sokolovska; Guillaume M Charriere; Laurent Boyer; Stephanie Dejardin; Michael P Cappillino; L Michael Yantosca; Kazue Takahashi; Kathryn J Moore; Adam Lacy-Hulbert; Lynda M Stuart
Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(12):7071-81.
2010: Cameron R Stewart; Lynda M Stuart; Kim Wilkinson; Janine M van Gils; Jiusheng Deng; Annett Halle; Katey J Rayner; Laurent Boyer; Ruiqin Zhong; William A Frazier; Adam Lacy-Hulbert; Joseph B El-Khoury; Douglas T Golenbock; Kathryn J Moore
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Nature immunology 2010;11(2):155-61.
2009: Mai X Luong; Joshua Tam; Qingcong Lin; Jeroen Hagendoorn; Kathryn J Moore; Timothy P Padera; Brian Seed; Dai Fukumura; Raju Kucherlapati; Rakesh K Jain
Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
Journal of cellular physiology 2009;219(2):430-7.
2009: Terry K Means; Eleftherios Mylonakis; Emmanouil Tampakakis; Richard A Colvin; Edward Seung; Lindsay Puckett; Melissa F Tai; Cameron R Stewart; Read Pukkila-Worley; Suzanne E Hickman; Kathryn J Moore; Stephen B Calderwood; Nir Hacohen; Andrew D Luster; Joseph B El-Khoury
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.
The Journal of experimental medicine 2009;206(3):637-53.
2008: W K Eddie Ip; Kazue Takahashi; Kathryn J Moore; Lynda M Stuart; R Alan B Ezekowitz
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.
The Journal of experimental medicine 2008;205(1):169-81.
2007: Nancy R Webb; Kathryn J Moore
Macrophage-derived foam cells in atherosclerosis: lessons from murine models and implications for therapy.
Current drug targets 2007;8(12):1249-63.
2007: Cameron R Stewart; Antonio Haw; Roland Lopez; Thomas O McDonald; judy callaghan; Malcolm J McConville; Kathryn J Moore; Geoffrey J Howlett; Kevin D O'Brien
Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications.
Journal of lipid research 2007;48(10):2162-71.
2007: Lynda M Stuart; Susan A Bell; Cameron R Stewart; Jessica M Silver; James Richard; Julie L Goss; Anita A Tseng; Ailiang Zhang; Joseph B El-Khoury; Kathryn J Moore
CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.
The Journal of biological chemistry 2007;282(37):27392-401.
2006: Geoffrey J Howlett; Kathryn J Moore
Untangling the role of amyloid in atherosclerosis.
Current opinion in lipidology 2006;17(5):541-7.
2006: Kathryn J Moore; Mason W Freeman
Scavenger receptors in atherosclerosis: beyond lipid uptake.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1702-11.
2006: Eric A Heller; Emerson Liu; Andrew M Tager; Qian Yuan; Alexander Y Lin; Neil Ahluwalia; Krister Jones; Stephanie L Koehn; Vincent M Lok; Elena Aikawa; Kathryn J Moore; Andrew D Luster; Robert E Gerszten
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
Circulation 2006;113(19):2301-12.
2005: Ngoc P Ly; Katsumi Komatsuzaki; Iain P Fraser; Anita A Tseng; Parthak Prodhan; Kathryn J Moore; T Bernard Kinane
Netrin-1 inhibits leukocyte migration in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14729-34.
2005: Kathryn J Moore; Vidya V Kunjathoor; Stephanie L Koehn; Jennifer J Manning; Anita A Tseng; Jessica M Silver; Mary McKee; Mason W Freeman
Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice.
The Journal of clinical investigation 2005;115(8):2192-201.
2005: Lynda M Stuart; Jiusheng Deng; Jessica M Silver; Kazue Takahashi; Anita A Tseng; Elizabeth J Hennessy; R Alan B Ezekowitz; Kathryn J Moore
Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain.
The Journal of cell biology 2005;170(3):477-85.
2005: Eric A Heller; Emerson Liu; Andrew M Tager; Sumita Sinha; Jesse D Roberts; Stephanie L Koehn; Peter Libby; Elena Aikawa; Ji Qiu Chen; Paul Huang; Mason W Freeman; Kathryn J Moore; Andrew D Luster; Robert E Gerszten
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation 2005;112(4):578-86.
2005: Cameron R Stewart; Anita A Tseng; Yee-Foong Mok; Maree K Staples; Carl H Schiesser; Lynne J Lawrence; Jose N Varghese; Kathryn J Moore; Geoffrey J Howlett
Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages.
Biochemistry 2005;44(25):9108-16.
2005: Woojin Scott Kim; Michael L Fitzgerald; Kihwa Kang; Kei-ichiro Okuhira; Susan A Bell; Jennifer J Manning; Stephanie L Koehn; Naifang Lu; Kathryn J Moore; Mason W Freeman
Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.
The Journal of biological chemistry 2005;280(5):3989-95.
2005: Marc A Laberge; Kathryn J Moore; Mason W Freeman
Atherosclerosis and innate immune signaling.
Annals of medicine 2005;37(2):130-40.
2004: Harry Björkbacka; Vidya V Kunjathoor; Kathryn J Moore; Stephanie L Koehn; Christine M Ordija; Melinda A Lee; Terry K Means; Kristen Halmen; Andrew D Luster; Douglas T Golenbock; Mason W Freeman
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.
Nature medicine 2004;10(4):416-21.
2004: Lea A Medeiros; Tayeba Khan; Joseph B El-Khoury; Chi L L Pham; Danny M Hatters; Geoffrey J Howlett; Roland Lopez; Kevin D O'Brien; Kathryn J Moore
Fibrillar amyloid protein present in atheroma activates CD36 signal transduction.
The Journal of biological chemistry 2004;279(11):10643-8.
2003: Joseph B El-Khoury; Kathryn J Moore; Terry K Means; Josephine Leung; Kinya Terada; Michelle Toft; Mason W Freeman; Andrew D Luster
CD36 mediates the innate host response to beta-amyloid.
The Journal of experimental medicine 2003;197(12):1657-66.
2002: Vidya V Kunjathoor; Maria Febbraio; Eugene A Podrez; Kathryn J Moore; Lorna Andersson; Stephanie L Koehn; Jeongmi S Rhee; Roy L Silverstein; Henry F Hoff; Mason W Freeman
Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.
The Journal of biological chemistry 2002;277(51):49982-8.
2002: Kathryn J Moore; Joseph B El-Khoury; Lea A Medeiros; Kinya Terada; Changiz Geula; Andrew D Luster; Mason W Freeman
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.
The Journal of biological chemistry 2002;277(49):47373-9.
2002: Michael L Fitzgerald; Kathryn J Moore; Mason W Freeman
Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home.
Journal of molecular medicine (Berlin, Germany) 2002;80(5):271-81.
2001: Kathryn J Moore; Michael L Fitzgerald; Mason W Freeman
Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?
Current opinion in lipidology 2001;12(5):519-27.
2001: Michael L Fitzgerald; Armando J Mendez; Kathryn J Moore; Lorna P Andersson; H A Panjeton; Mason W Freeman
ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space.
The Journal of biological chemistry 2001;276(18):15137-45.
2001: Kathryn J Moore; Evan D Rosen; Michael L Fitzgerald; F Randow; Lorna P Andersson; D Altshuler; David S Milstone; richard mortensen; Bruce M Spiegelman; Mason W Freeman
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Nature medicine 2001;7(1):41-7.
2000: Kathryn J Moore; Lorna P Andersson; Robin R Ingalls; Brian G Monks; R Li; M Amin Arnaout; Douglas T Golenbock; Mason W Freeman
Divergent response to LPS and bacteria in CD14-deficient murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4272-80.
2000: Michael L Fitzgerald; Kathryn J Moore; Mason W Freeman; Guy L Reed
Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2692-700.
1998: Kathryn J Moore; R P Fabunmi; Lorna P Andersson; Mason W Freeman
In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1647-54.