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Philip Moore

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Balasubramanian Srilatha; Paulpandi Muthulakshmi; P Ganesan Adaikan; Philip K Moore
Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats.
Zhao Feng Peng; Françoise Russo-Marie; Guanghou Shui; Matthew Whiteman; Philip M Beart; Minghui Jessica Chen; Jayapal Manikandan; Alirio J Melendez; Philip K Moore; Nam Sang Cheung
Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades.
Shufen Huang; Jia Hui Chua; Wen Shan Yew; J Sivaraman; Philip K Moore; Choon-Hong Tan; Lih-Wen Deng
Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.

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All Publications

2012: Balasubramanian Srilatha; Paulpandi Muthulakshmi; P Ganesan Adaikan; Philip K Moore
Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats.
The aging male : the official journal of the International Society for the Study of the Aging Male 2012;15(3):153-8.
2012: Zhao Feng Peng; Françoise Russo-Marie; Guanghou Shui; Matthew Whiteman; Philip M Beart; Minghui Jessica Chen; Jayapal Manikandan; Alirio J Melendez; Philip K Moore; Nam Sang Cheung
Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades.
Journal of cellular and molecular medicine 2012;16(1):41-58.
2010: Shufen Huang; Jia Hui Chua; Wen Shan Yew; J Sivaraman; Philip K Moore; Choon-Hong Tan; Lih-Wen Deng
Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.
Journal of molecular biology 2010;396(3):708-18.
2009: Qingxiang Sun; Ruairi Collins; Shufen Huang; Lovisa Holmberg Schiavone; Ganesh S Anand; Choon-Hong Tan; Susanne van-den-Berg; Lih-Wen Deng; Philip K Moore; Tobias Karlberg; J Sivaraman
Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.
The Journal of biological chemistry 2009;284(5):3076-85.
2008: Rajamanickam Baskar; Philip K Moore
Nuclear accumulation and up-regulation of p53 and its associated proteins after H2S treatment in human lung fibroblasts.
Journal of cellular and molecular medicine 2008;12(6A):2297-300.
2008: Rajamanickam Baskar; Anna Sparatore; Piero Del Soldato; Philip K Moore
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation.
European journal of pharmacology 2008;594(1-3):1-8.
2008: Ling Li; Matthew Whiteman; Yan Yi Guan; Kay Li Neo; Yvonne Cheng; Shiau Wei Lee; Yujun Zhao; Rajamanickam Baskar; Choon-Hong Tan; Philip K Moore
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.
Circulation 2008;117(18):2351-60.
2008: Ramasamy Tamizhselvi; Philip K Moore; Madhav Bhatia
Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury.
Pancreas 2008;36(4):e24-31.
2008: Andy Thiam-Huat Lee; J Jitendrakumar Shah; Ling Li; Y Cheng; Philip K Moore; Sanjay Khanna
A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain.
Neuroscience 2008;152(1):89-96.
2008: Gavin Dawe; S P Han; Jin-Song Bian; Philip K Moore
Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats.
Neuroscience 2008;152(1):169-77.
2008: Zhao Feng Peng; Minghui Jessica Chen; Yann Wan Yap; Manikandan Jayapal; Alirio J Melendez; Meng Shyan Choy; Philip K Moore; Nam Sang Cheung
Proteasome inhibition: an early or late event in nitric oxide-induced neuronal death?
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;18(2):136-45.
2008: George D Webb; Lay Har Lim; Vernon M S Oh; Soh Bee Yeo; Yoke Ping Cheong; Muhammed Yusuf Ali; Reida El Oakley; Chuen Neng Lee; Poo-Sing Wong; Michael G Caleb; Manuel Salto-Tellez; Madhav Bhatia; Edwin S Y Chan; Elizabeth A Taylor; Philip K Moore
Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery.
The Journal of pharmacology and experimental therapeutics 2008;324(2):876-82.
2008: Yeshi Hu; Xin Chen; Ting-Ting Pan; Kay Li Neo; Shiau Wei Lee; Ester Sandar Win Khin; Philip K Moore; Jin-Song Bian
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
Pflügers Archiv : European journal of physiology 2008;455(4):607-16.
2008: Madhav Bhatia; Jenab Sidhapuriwala; Anna Sparatore; Philip K Moore
Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury.
Shock (Augusta, Ga.) 2008;29(1):84-8.
2007: Shin Chet Chuah; Philip K Moore; Yi-Zhun Zhu
S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H2693-701.
2007: Muhammed Yusuf Ali; Matthew Whiteman; Chian-Ming Low; Philip K Moore
Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway.
The Journal of endocrinology 2007;195(1):105-12.
2007: Wen-Jie Cai; Ming-Jie Wang; Philip K Moore; Hui-ming Jin; Tai Yao; Yi-Chun Zhu
The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation.
Cardiovascular research 2007;76(1):29-40.
2007: Ying-Xian Shi; Ying Chen; Yi-Zhun Zhu; Guo-ying Huang; Philip K Moore; Shan-Hong Huang; Tai Yao; Yi-Chun Zhu
Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2093-100.
2007: Huili Zhang; Liang Zhi; Shabbir M Moochhala; Philip K Moore; Madhav Bhatia
Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis.
Journal of leukocyte biology 2007;82(4):894-905.
2007: Nam Sang Cheung; Zhao Feng Peng; Minghui Jessica Chen; Philip K Moore; Matthew Whiteman
Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons.
Neuropharmacology 2007;53(4):505-14.
2007: Balasubramanian Srilatha; P Ganesan Adaikan; Ling Li; Philip K Moore
Hydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile function.
The journal of sexual medicine 2007;4(5):1304-11.
2007: Yilong Fu; Zhongjing Wang; Woei Lee Chen; Philip K Moore; Yi-Zhun Zhu
Cardioprotective effects of nitric oxide-aspirin in myocardial ischemia-reperfused rats.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1545-52.
2007: Jenab Sidhapuriwala; Ling Li; Anna Sparatore; Madhav Bhatia; Philip K Moore
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.
European journal of pharmacology 2007;569(1-2):149-54.
2007: Shiau Wei Lee; Yvonne Cheng; Philip K Moore; Jin-Song Bian
Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells.
Biochemical and biophysical research communications 2007;358(4):1142-7.
2007: Liang Zhi; Abel Damien Ang; Huili Zhang; Philip K Moore; Madhav Bhatia
Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway.
Journal of leukocyte biology 2007;81(5):1322-32.
2007: H C Liew; Hoon Eng Khoo; Philip K Moore; Madhav Bhatia; Jia Lu; Shabbir M Moochhala
Synergism between hydrogen sulfide (H(2)S) and nitric oxide (NO) in vasorelaxation induced by stonustoxin (SNTX), a lethal and hypotensive protein factor isolated from stonefish Synanceja horrida venom.
Life sciences 2007;80(18):1664-8.
2007: Huili Zhang; Liang Zhi; Shabbir M Moochhala; Philip K Moore; Madhav Bhatia
Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB.
American journal of physiology. Lung cellular and molecular physiology 2007;292(4):L960-71.
2007: Ramasamy Tamizhselvi; Philip K Moore; Madhav Bhatia
Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells.
Journal of cellular and molecular medicine 2007;11(2):315-26.
2007: Ling Li; Giuseppe Rossoni; Anna Sparatore; Lin Chiou Lee; Piero Del Soldato; Philip K Moore
Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative.
Free radical biology & medicine 2007;42(5):706-19.
2007: Li-Fang Hu; Peter T-H Wong; Philip K Moore; Jin-Song Bian
Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia.
Journal of neurochemistry 2007;100(4):1121-8.
2007: Rajamanickam Baskar; Ling Li; Philip K Moore
Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):247-55.
2007: Yi-Zhun Zhu; Zhong Jing Wang; Peiying Ho; Yoke Yun Loke; Yi Chun Zhu; Shan Hong Huang; Chee Sin Tan; Matthew Whiteman; Jia Lu; Philip K Moore
Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(1):261-8.
2006: Farhana Anuar; Matthew Whiteman; Madhav Bhatia; Philip K Moore
Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2006;55(11):498-503.
2006: George D Webb; Lay Har Lim; Vernon M S Oh; Reida El Oakley; Chuen Neng Lee; Poo-Sing Wong; W Maung Maung Aye; Edwin S Y Chan; Philip K Moore
Expression of neuronal nitric oxide synthase in the internal thoracic artery and saphenous vein.
The Journal of thoracic and cardiovascular surgery 2006;132(5):1131-6.
2006: Muhammed Yusuf Ali; C Y Ping; Y-Yp Mok; L Ling; Matthew Whiteman; Madhav Bhatia; Philip K Moore
Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?
British journal of pharmacology 2006;149(6):625-34.
2006: Madhav Bhatia; Liang Zhi; Huili Zhang; Siaw Wei Ng; Philip K Moore
Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice.
American journal of physiology. Lung cellular and molecular physiology 2006;291(5):L896-904.
2006: Yang Cao; Sharmila Adhikari; Abel Damien Ang; Philip K Moore; Madhav Bhatia
Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.
American journal of physiology. Cell physiology 2006;291(3):C503-10.
2006: Yi-Chun Zhu; Yi-Zhun Zhu; Philip K Moore
The role of urotensin II in cardiovascular and renal physiology and diseases.
British journal of pharmacology 2006;148(7):884-901.
2006: Shiau Wei Lee; Ye-Shi Hu; Li-Fang Hu; Qing Lu; Gavin Dawe; Philip K Moore; Peter T-H Wong; Jin-Song Bian
Hydrogen sulphide regulates calcium homeostasis in microglial cells.
Glia 2006;54(2):116-24.
2006: Huili Zhang; Liang Zhi; Philip K Moore; Madhav Bhatia
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.
American journal of physiology. Lung cellular and molecular physiology 2006;290(6):L1193-201.
2006: Matthew Whiteman; Ling Li; Iouri Kostetski; Siew Hwa Chu; Jia Ling Siau; Madhav Bhatia; Philip K Moore
Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide.
Biochemical and biophysical research communications 2006;343(1):303-10.
2006: Farhana Anuar; Matthew Whiteman; Jia Ling Siau; Shing Erl Kwong; Madhav Bhatia; Philip K Moore
Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat.
British journal of pharmacology 2006;147(8):966-74.
2006: Ling Li; Madhav Bhatia; Philip K Moore
Hydrogen sulphide--a novel mediator of inflammation?
Current opinion in pharmacology 2006;6(2):125-9.
2006: Balasubramanian Srilatha; P Ganesan Adaikan; Philip K Moore
Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study.
European journal of pharmacology 2006;535(1-3):280-2.
2006: Kun Qu; Christopher P L-H Chen; Barry Halliwell; Philip K Moore; Peter T-H Wong
Hydrogen sulfide is a mediator of cerebral ischemic damage.
Stroke; a journal of cerebral circulation 2006;37(3):889-93.
2006: Jin-Song Bian; Qian Chen Yong; Ting-Ting Pan; Zhan-Ning Feng; Muhammed Yusuf Ali; Shufeng Zhou; Philip K Moore
Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes.
The Journal of pharmacology and experimental therapeutics 2006;316(2):670-8.
2006: Yi-Zhun Zhu; Chew Lan Chong; Shin Chet Chuah; Shan Hong Huang; Huey Shan Nai; How Teng Tong; Matt Whiteman; Philip K Moore
Cardioprotective effects of nitroparacetamol and paracetamol in acute phase of myocardial infarction in experimental rats.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H517-24.
2006: Ting-Ting Pan; Zhan-Ning Feng; Shiau Wei Lee; Philip K Moore; Jin-Song Bian
Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes.
Journal of molecular and cellular cardiology 2006;40(1):119-30.
2005: Yeow Leng Chua; Dawei Zhang; Urs Boelsterli; Philip K Moore; Matthew Whiteman; Jeffrey S Armstrong
Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA.
Biochemical and biophysical research communications 2005;337(1):375-81.
2005: Marika Collin; Farhana Anuar; Oliver Murch; Madhav Bhatia; Philip K Moore; Christoph Thiemermann
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia.
British journal of pharmacology 2005;146(4):498-505.
2005: Muhammed Yusuf; Benny Tan Kwong Huat; A Hsu; Matthew Whiteman; Madhav Bhatia; Philip K Moore
Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis.
Biochemical and biophysical research communications 2005;333(4):1146-52.
2005: Jiali Huang; Shabbir M Moochhala; Philip K Moore; Madhav Bhatia
Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury.
Shock (Augusta, Ga.) 2005;24(2):182-7.
2005: Peter Rose; Philip K Moore; Shen-Han Ming; Ong-Choon Nam; Jeffrey S Armstrong; Matthew Whiteman
Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis.
World journal of gastroenterology : WJG 2005;11(26):3990-7.
2005: Ling Li; Madhav Bhatia; Yi-Zhun Zhu; Yi Chun Zhu; Raina Devi Ramnath; Zhong Jing Wang; Farhana Anuar; Matthew Whiteman; Manuel Salto-Tellez; Philip K Moore
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1196-8.
2005: Peter Rose; Matthew Whiteman; Philip K Moore; Yi-Zhun Zhu
Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.
Natural product reports 2005;22(3):351-68.
2005: Madhav Bhatia; Jenab Sidhapuriwala; Shabbir M Moochhala; Philip K Moore
Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat.
British journal of pharmacology 2005;145(2):141-4.
2005: Madhav Bhatia; Fei Ling Wong; Di Fu; Hon Yen Lau; Shabbir M Moochhala; Philip K Moore
Role of hydrogen sulfide in acute pancreatitis and associated lung injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(6):623-5.
2005: Matthew Whiteman; Nam Sang Cheung; Yi-Zhun Zhu; Siew Hwa Chu; Jia Ling Siau; Boon-Seng Wong; Jeffrey S Armstrong; Philip K Moore
Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?
Biochemical and biophysical research communications 2005;326(4):794-8.
2004: Ying-Yuan Pamela Mok; Mohammed Shirhan Bin Mohammed Atan; Cheong Yoke Ping; Wang Zhong Jing; Madhav Bhatia; Shabbir M Moochhala; Philip K Moore
Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis.
British journal of pharmacology 2004;143(7):881-9.
2004: Matthew Whiteman; Jeffrey S Armstrong; Siew Hwa Chu; Siau Jia-Ling; Boon-Seng Wong; Nam Sang Cheung; Barry Halliwell; Philip K Moore
The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?
Journal of neurochemistry 2004;90(3):765-8.
2003: Philip K Moore; Madhav Bhatia; Shabbir M Moochhala
Hydrogen sulfide: from the smell of the past to the mediator of the future?
Trends in pharmacological sciences 2003;24(12):609-11.