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William Moore

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Peter V N Bodine; Barbara Stauffer; Helga Ponce-de-Leon; Ramesh A Bhat; Annamarie Mangine; Laura M Seestaller-Wehr; Robert A Moran; Julia Billiard; Shoichi Fukayama; Barry S Komm; Keith Pitts; Girija Krishnamurthy; Ariamala Gopalsamy; Mengxiao Shi; Jeffrey C Kern; Thomas J Commons; Richard P Woodworth; Matthew A Wilson; Gregory S Welmaker; Eugene J Trybulski; William J Moore
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
An T Vu; Stephen T Cohn; Eugene A Terefenko; William J Moore; Puwen Zhang; Paige E Mahaney; Eugene Trybulski; Igor Goljer; Rebecca Dooley; Jenifer A Bray; Grace H Johnston; Jennifer Leiter; Darlene C Deecher
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
Derek C Cole; Joseph R Stock; Anthony F Kreft; Madelene Antane; Suzan H Aschmies; Kevin P Atchison; David S Casebier; thomas Comery; George Diamantidis; John W Ellingboe; Boyd L Harrison; Yun Hu; Mei Jin; Dennis M Kubrak; Peimin Lu; Charles W Mann; Robert L Martone; William J Moore; Aram Oganesian; David Riddell; June Sonnenberg-Reines; Shaiu-Ching Sun; Erik Wagner; Zheng Wang; Kevin R Woller; Zheng Xu; Hua Zhou; J Steven Jacobsen
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.

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All Publications

2009: Peter V N Bodine; Barbara Stauffer; Helga Ponce-de-Leon; Ramesh A Bhat; Annamarie Mangine; Laura M Seestaller-Wehr; Robert A Moran; Julia Billiard; Shoichi Fukayama; Barry S Komm; Keith Pitts; Girija Krishnamurthy; Ariamala Gopalsamy; Mengxiao Shi; Jeffrey C Kern; Thomas J Commons; Richard P Woodworth; Matthew A Wilson; Gregory S Welmaker; Eugene J Trybulski; William J Moore
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
Bone 2009;44(6):1063-8.
2009: An T Vu; Stephen T Cohn; Eugene A Terefenko; William J Moore; Puwen Zhang; Paige E Mahaney; Eugene Trybulski; Igor Goljer; Rebecca Dooley; Jenifer A Bray; Grace H Johnston; Jennifer Leiter; Darlene C Deecher
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(9):2464-7.
2009: Derek C Cole; Joseph R Stock; Anthony F Kreft; Madelene Antane; Suzan H Aschmies; Kevin P Atchison; David S Casebier; thomas Comery; George Diamantidis; John W Ellingboe; Boyd L Harrison; Yun Hu; Mei Jin; Dennis M Kubrak; Peimin Lu; Charles W Mann; Robert L Martone; William J Moore; Aram Oganesian; David Riddell; June Sonnenberg-Reines; Shaiu-Ching Sun; Erik Wagner; Zheng Wang; Kevin R Woller; Zheng Xu; Hua Zhou; J Steven Jacobsen
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Bioorganic & medicinal chemistry letters 2009;19(3):926-9.
2009: William J Moore; Jeffrey C Kern; Ramesh Bhat; Thomas J Commons; Shoichi Fukayama; Igor Goljer; Girija Krishnamurthy; Ronald L Magolda; Lisa Nogle; Keith Pitts; Barb Stauffer; Eugene Trybulski; Gregory S Welmaker; Matthew Wilson; Peter V N Bodine
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
Journal of medicinal chemistry 2009;52(1):105-16.
2008: Derek C Cole; Joseph R Stock; Rajiv Chopra; Rebecca Cowling; John W Ellingboe; Kristi Y Fan; Boyd L Harrison; Yun Hu; Steve Jacobsen; Lee D Jennings; Guixian Jin; Peter A Lohse; Michael S Malamas; Eric S Manas; William J Moore; Mary-Margaret O'Donnell; Andrea M Olland; Albert J Robichaud; Kristine Svenson; JunJun Wu; Eric Wagner; Jonathan Bard
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Bioorganic & medicinal chemistry letters 2008;18(3):1063-6.
2008: Lee D Jennings; Derek C Cole; Joseph R Stock; Mohani N Sukhdeo; John W Ellingboe; Rebecca Cowling; Guixian Jin; Eric S Manas; Kristi Y Fan; Michael S Malamas; Boyd L Harrison; Steve Jacobsen; Rajiv Chopra; Peter A Lohse; William J Moore; Mary-Margaret O'Donnell; Yun Hu; Albert J Robichaud; M James Turner; Erik Wagner; Jonathan Bard
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Bioorganic & medicinal chemistry letters 2008;18(2):767-71.
2006: Joseph P Sabatucci; Mark A Ashwell; Eugene Trybulski; Mary-Margaret O'Donnell; William J Moore; Douglas C Harnish; Christopher C Chadwick
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.
Bioorganic & medicinal chemistry letters 2006;16(4):854-8.
2006: Robert J Steffan; Edward Matelan; Mark A Ashwell; William J Moore; William R Solvibile; Eugene Trybulski; Christopher C Chadwick; Susan Chippari; Thomas Kenney; Richard Winneker; Amy Eckert; Lisa Borges-Marcucci; Steven J Adelman; Zhang Xu; Lidia Mosyak; Douglas C Harnish
Control of chronic inflammation with pathway selective estrogen receptor ligands.
Current topics in medicinal chemistry 2006;6(2):103-11.
2005: Neelu Kaila; William S Somers; Bert Thomas; Paresh Thakker; Kristin Janz; Silvano DeBernardo; Steve Tam; William J Moore; Ruiyang Yang; Wojciech Wrona; Patricia W Bedard; Deidre Crommie; James Carl Keith; Desirée H H Tsao; Juan Alvarez; Heyu Ni; Erik Marchese; John T Patton; John L Magnani; Raymond T Camphausen
Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.
Journal of medicinal chemistry 2005;48(13):4346-57.
2004: Robert J Steffan; Edward Matelan; Mark A Ashwell; William J Moore; William R Solvibile; Eugene Trybulski; Christopher C Chadwick; Susan Chippari; Thomas Kenney; Amy Eckert; Lisa Borges-Marcucci; James Carl Keith; Zhang Xu; Lidia Mosyak; Douglas C Harnish
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.
Journal of medicinal chemistry 2004;47(26):6435-8.