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Bhagavatula Moorthy

Research Profile

Chemicals & Drugs

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Hyperoxia

Physiology

Enzyme Induction

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TOP 3
Binoy Shivanna; Lihua Wang; Stephen E Welty; Wenyan Zhang; Xanthi I Couroucli; Weiwu Jiang; Bhagavatula Moorthy
Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.
Adarsh Gandhi; Tao Guo; Bhagavatula Moorthy; Pranav Shah; Romi Ghose
Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice.
Adarsh Gandhi; Bhagavatula Moorthy; Romi Ghose
Drug disposition in pathophysiological conditions.

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All Publications

2013: Binoy Shivanna; Lihua Wang; Stephen E Welty; Wenyan Zhang; Xanthi I Couroucli; Weiwu Jiang; Bhagavatula Moorthy
Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.
Toxicology and applied pharmacology 2013;267(3):209-17.
2013: Adarsh Gandhi; Tao Guo; Bhagavatula Moorthy; Pranav Shah; Romi Ghose
Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice.
Toxicology and applied pharmacology 2013;266(3):430-8.
2012: Adarsh Gandhi; Bhagavatula Moorthy; Romi Ghose
Drug disposition in pathophysiological conditions.
Current drug metabolism 2012;13(9):1327-44.
2012: Yang Lin; Senyan Liu; Bhagavatula Moorthy; Lihua Wang; Dongsheng Xiong; Yunyi Yao; Tao Cheng; Xinxin Ding; Jun Gu
Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice.
Toxicology letters 2012;212(2):97-105.
2011: Binoy Shivanna; Lihua Wang; Stephen E Welty; Chun Chu; Xanthi I Couroucli; Weiwu Jiang; Bhagavatula Moorthy
Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor.
Free radical biology & medicine 2011;51(10):1910-7.
2011: Xanthi I Couroucli; Weiwu Jiang; Yan-hong Wei Liang; Lihua Wang; Peiying Yang; Roberto Barrios; Bhagavatula Moorthy
Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants.
Toxicology and applied pharmacology 2011;256(2):83-94.
2011: Binoy Shivanna; Lihua Wang; Xanthi I Couroucli; Weiwu Jiang; Bhagavatula Moorthy
Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes.
The Journal of pharmacology and experimental therapeutics 2011;339(1):106-14.
2011: Weiwu Jiang; Xanthi I Couroucli; Lihua Wang; Roberto Barrios; Bhagavatula Moorthy
Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.
Biochemical and biophysical research communications 2011;407(1):79-85.
2011: Guo-Dong Zhou; Huiping Zhu; Brad A Amendt; Xanthi I Couroucli; Kirby C Donnelly; Tracie D Phillips; Fen Wang; Jianbo Wang; Shi-Zhou Wang; Bhagavatula Moorthy
Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.
PloS one 2011;6(10):e26589.
2010: Guo-Dong Zhou; Molly Richardson; Inayat S Fazili; Jianbo Wang; Kirby C Donnelly; Fen Wang; Brad Amendt; Bhagavatula Moorthy
Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: implications for cancer prevention.
Toxicology and applied pharmacology 2010;249(3):224-30.
2010: Weiwu Jiang; Lihua Wang; Sudha R Kondraganti; Inayat S Fazili; Xanthi I Couroucli; Edward A Felix; Bhagavatula Moorthy
Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.
The Journal of pharmacology and experimental therapeutics 2010;335(2):369-79.
2010: Inayat S Fazili; Weiwu Jiang; Lihua Wang; Edward A Felix; Tanvir Khatlani; Xavier COUMOUL; Robert Barouki; Bhagavatula Moorthy
Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.
The Journal of pharmacology and experimental therapeutics 2010;333(1):99-109.
2009: Weiwu Jiang; Lihua Wang; Weisheng Zhang; Richard Coffee; Inayat S Fazili; Bhagavatula Moorthy
Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters.
Biochemical and biophysical research communications 2009;390(4):1419-24.
2009: P V Sravani; N Kishore Babu; K V T Gopal; G Raghu Rama Rao; Athota Rama Rao; Bhagavatula Moorthy; T Raghava Rao
Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin.
Indian journal of dermatology, venereology and leprology 2009;75(3):268-71.
2008: Kushal Y Bhakta; Weiwu Jiang; Xanthi I Couroucli; Inayat S Fazili; Kathirvel Muthiah; Bhagavatula Moorthy
Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury.
Toxicology and applied pharmacology 2008;233(2):169-78.
2008: Sudha R Kondraganti; Weiwu Jiang; Anil K Jaiswal; Bhagavatula Moorthy
Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2008;102(2):337-44.
2007: Guo-Dong Zhou; Bhagavatula Moorthy; Jia Bi; Kirby C Donnelly; Kurt Randerath
DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human (HepG2) cells.
Environmental and molecular mutagenesis 2007;48(9):715-21.
2007: Reddy P Kommaddi; Cheri Marie Turman; Bhagavatula Moorthy; Lihua Wang; Henry W Strobel; Vijayalakshmi Ravindranath
An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites.
Journal of neurochemistry 2007;102(3):867-77.
2007: Bhagavatula Moorthy; Kathirvel Muthiah; Inayat S Fazili; Sudha R Kondraganti; Lihua Wang; Xanthi I Couroucli; Weiwu Jiang
3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells.
Biochemical and biophysical research communications 2007;354(4):1071-7.
2006: Xanthi I Couroucli; Yanhong W Liang; Weiwu Jiang; Roberto Barrios; Bhagavatula Moorthy
Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes.
The Journal of pharmacology and experimental therapeutics 2006;317(3):946-54.
2006: Amitava Das; Labanyamoy Kole; Lihua Wang; Roberto Barrios; Bhagavatula Moorthy; Anil K Jaiswal
BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2.
Free radical biology & medicine 2006;40(10):1843-56.
2006: Xanthi I Couroucli; Yan-Hong Wei; Weiwu Jiang; Kathirvel Muthiah; Lee W Evey; Roberto Barrios; Bhagavatula Moorthy
Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat: implications for lung injury.
Pediatric research 2006;59(3):401-6.
2005: Sudha R Kondraganti; Kathirvel Muthiah; Weiwu Jiang; Roberto Barrios; Bhagavatula Moorthy
Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses.
Chemical research in toxicology 2005;18(11):1634-41.
2005: Anuj Sinha; Kathirvel Muthiah; Weiwu Jiang; Xanthi I Couroucli; Roberto Barrios; Bhagavatula Moorthy
Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(1):204-12.
2005: Noé Galván; Doug E Teske; Guodong Zhou; Bhagavatula Moorthy; Peter S MacWilliams; Charles J Czuprynski; Colin R Jefcoate
Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity.
Toxicology and applied pharmacology 2005;202(3):244-57.
2005: Kenneth S Ramos; Bhagavatula Moorthy
Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis.
Drug metabolism reviews 2005;37(4):595-610.
2004: Weisheng Zhang; Bhagavatula Moorthy; Min Chen; Kathirvel Muthiah; Richard Coffee; Anthony F Purchio; David B West
A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(1):297-307.
2004: Weiwu Jiang; Stephen E Welty; Xanthi I Couroucli; Roberto Barrios; Sudha R Kondraganti; Kathirvel Muthiah; Ling Yu; Stephen E Avery; Bhagavatula Moorthy
Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
The Journal of pharmacology and experimental therapeutics 2004;310(2):512-9.
2003: Bhagavatula Moorthy; Kimberly P Miller; Weiwu Jiang; E Spencer Williams; Sudha R Kondraganti; Kenneth S Ramos
Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates.
The Journal of pharmacology and experimental therapeutics 2003;305(1):394-401.
2003: Sudha R Kondraganti; Pedro Fernandez-Salguero; Frank J Gonzalez; Kenneth S Ramos; Weiwu Jiang; Bhagavatula Moorthy
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.
International journal of cancer. Journal international du cancer 2003;103(1):5-11.
2002: Sudha R Kondraganti; Weiwu Jiang; Bhagavatula Moorthy
Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene.
The Journal of pharmacology and experimental therapeutics 2002;303(3):945-51.
2002: Bhagavatula Moorthy; Kimberly P Miller; Weiwu Jiang; Kenneth S Ramos
The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1.
Cardiovascular research 2002;53(4):1002-9.
2002: Xanthi I Couroucli; Stephen E Welty; Robert S Geske; Bhagavatula Moorthy
Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury.
Molecular pharmacology 2002;61(3):507-15.
2002: Bhagavatula Moorthy
3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene.
Redox report : communications in free radical research 2002;7(1):9-13.
2002: Donghui Li; Mian-Ying Wang; Pervez F Firozi; Ping Chang; Weiqing Zhang; Wanda Baer-Dubowska; Bhagavatula Moorthy; Suryanarayana V Vulimiri; Regine Goth-Goldstein; Eric H Weyand; John DiGiovanni
Characterization of a major aromatic DNA adduct detected in human breast tissues.
Environmental and molecular mutagenesis 2002;39(2-3):193-200.
2000: Bhagavatula Moorthy
Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues.
The Journal of pharmacology and experimental therapeutics 2000;294(1):313-22.
2000: Bhagavatula Moorthy; K M Parker; Charles V Smith; J R Bend; Stephen E Welty
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
The Journal of pharmacology and experimental therapeutics 2000;292(2):553-60.
1998: Kurt Randerath; P Sriram; Bhagavatula Moorthy; J P Aston; R A Baan; P T van den Berg; Ewan D Booth; William P Watson
Comparison of immunoaffinity chromatography enrichment and nuclease P1 procedures for 32P-postlabelling analysis of PAH-DNA adducts.
Chemico-biological interactions 1998;110(1-2):85-102.
1997: Lynette K Rogers; Bhagavatula Moorthy; Charles V Smith
Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses.
Chemical research in toxicology 1997;10(4):470-6.
1997: Bhagavatula Moorthy; P Sriram; E Randerath; Kurt Randerath
Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo.
Biochemical pharmacology 1997;53(5):663-9.
1997: Bhagavatula Moorthy; U T Nguyen; S Gupta; K D Stewart; Stephen E Welty; Charles V Smith
Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha.
Toxicology letters 1997;90(1):67-75.
1996: N Mabon; Bhagavatula Moorthy; E Randerath; Kurt Randerath
Monophosphate 32P-postlabeling assay of DNA adducts from 1,2:3,4-diepoxybutane, the most genotoxic metabolite of 1,3-butadiene: in vitro methodological studies and in vivo dosimetry.
Mutation research 1996;371(1-2):87-104.
1996: Bhagavatula Moorthy; Kurt Randerath
Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol.
Archives of toxicology 1996;70(11):696-703.
1996: Bhagavatula Moorthy; P Sriram; D N Pathak; William J Bodell; Kurt Randerath
Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo.
Cancer research 1996;56(1):53-7.
1995: Bhagavatula Moorthy; P Sriram; Kurt Randerath
Effects of a single dose of the cytochrome P450 inducer, beta-naphthoflavone, on hepatic and renal covalent DNA modifications (I-compounds).
Toxicology 1995;104(1-3):165-77.
1995: Bhagavatula Moorthy; JG Liehr; E Randerath; Kurt Randerath
Evidence from 32P-postlabeling and the use of pentachlorophenol for a novel metabolic activation pathway of diethylstilbestrol and its dimethyl ether in mouse live: likely alpha-hydroxylation of ethyl group(s) followed by sulfate conjugation.
Carcinogenesis 1995;16(11):2643-8.
1995: S V Vulimiri; S Gupta; Charles V Smith; Bhagavatula Moorthy; Kurt Randerath
Rapid decreases in indigenous covalent DNA modifications (I-compounds) of male Fischer-344 rat liver DNA by diquat treatment.
Chemico-biological interactions 1995;95(1-2):1-16.
1994: Kurt Randerath; Bhagavatula Moorthy; N Mabon; P Sriram
Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite.
Carcinogenesis 1994;15(10):2087-94.
1994: Kurt Randerath; J Bi; N Mabon; P Sriram; Bhagavatula Moorthy
Strong intensification of mouse hepatic tamoxifen DNA adduct formation by pretreatment with the sulfotransferase inhibitor and ubiquitous environmental pollutant pentachlorophenol.
Carcinogenesis 1994;15(5):797-800.
1994: Bhagavatula Moorthy; P Sriram; Kurt Randerath
Chemical structure- and time-dependent effects of polycyclic aromatic hydrocarbon-type inducers on rat liver cytochrome P450, DNA adducts, and I-compounds.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;22(4):549-60.
1993: Bhagavatula Moorthy; S Chen; Donghui Li; Kurt Randerath
3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: possible link between P450 turnover and formation of DNA adducts and I-compounds.
Carcinogenesis 1993;14(5):879-86.
1993: Kurt Randerath; Donghui Li; Bhagavatula Moorthy; E Randerath
I-compounds--endogenous DNA markers of nutritional status, ageing, tumour promotion and carcinogenesis.
IARC scientific publications 1993;(124):157-65.
1992: Donghui Li; Bhagavatula Moorthy; S Chen; Kurt Randerath
Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA.
Carcinogenesis 1992;13(7):1191-8.
1992: Bhagavatula Moorthy; K L van Golen; Kurt Randerath
Sex-specific modulation of hepatic covalent DNA modifications (I-compounds) by the cytochrome P450 inducer, pregnenolone-16 alpha-carbonitrile.
Toxicology and applied pharmacology 1992;113(2):218-26.