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Carlos Moraes

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TOP 3
Alicia M Pickrell; Milena Pinto; Carlos T Moraes
Mouse models of Parkinson's disease associated with mitochondrial dysfunction.
Sandra R Bacman; D Duan; Siôn L Williams; Carlos T Moraes
Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.
Michael G White; Ellen F Barrett; Carlos T Moraes; Doris Nonner; Osama Saleh; John N Barrett
Mitochondrial dysfunction induced by heat stress in cultured rat CNS neurons.

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All Publications

2013: Alicia M Pickrell; Milena Pinto; Carlos T Moraes
Mouse models of Parkinson's disease associated with mitochondrial dysfunction.
Molecular and cellular neurosciences 2013;55():87-94.
2012: Sandra R Bacman; D Duan; Siôn L Williams; Carlos T Moraes
Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.
Gene therapy 2012;19(11):1101-6.
2012: Michael G White; Ellen F Barrett; Carlos T Moraes; Doris Nonner; Osama Saleh; John N Barrett
Mitochondrial dysfunction induced by heat stress in cultured rat CNS neurons.
Journal of neurophysiology 2012;108(8):2203-14.
2012: Susana Peralta; Xiao Wang; Carlos T Moraes
Mitochondrial transcription: lessons from mouse models.
Biochimica et biophysica acta 2012;1819(9-10):961-9.
2012: Ursula Fünfschilling; Sandra Goebbels; Bernd Hamprecht; Celia M Kassmann; Don Mahad; Dies Meijer; Wiebke Möbius; Carlos T Moraes; Susann Boretius; Bastian G Brinkmann; Francisca Diaz; Julia Edgar; Jens Frahm; Aiman S Saab; Michael W Sereda; Lotti M Supplie; Ueli Suter; Iva D Tzvetanova; Klaus-Armin Nave
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Nature 2012;485(7399):517-21.
2012: Lloye M Dillon; Aline Hida; Joy Lincoln; Jacqueline D Peacock; Tomas A Prolla; Siôn L Williams; Carlos T Moraes
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse.
Human molecular genetics 2012;21(10):2288-97.
2012: milena pinto; Alicia M Pickrell; Carlos T Moraes
Regional susceptibilities to mitochondrial dysfunctions in the CNS.
Biological chemistry 2012;393(4):275-81.
2012: Lloye M Dillon; Adriana P Rebelo; Carlos T Moraes
The role of PGC-1 coactivators in aging skeletal muscle and heart.
IUBMB life 2012;64(3):231-41.
2012: Juliana Gamba; Luana T Gamba; Beatriz H Kiyomoto; Carlos T Moraes; Gabriela S Rodrigues; Célia H Tengan
Nitric Oxide Synthesis Is Increased in Cybrid Cells with m.3243A>G Mutation.
International journal of molecular sciences 2012;14(1):394-410.
2012: Lloye M Dillon; Sofia Garcia; Aline Hida; Tomas A Prolla; Carlos T Moraes
Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse.
PloS one 2012;7(9):e44335.
2012: Xiao Wang; Teresa Zimmers; Alicia M Pickrell; Carlos T Moraes
Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia.
PloS one 2012;7(3):e33426.
2012: Francisca Diaz; José Antonio Enríquez; Carlos T Moraes
Cells lacking Rieske iron-sulfur protein have a reactive oxygen species-associated decrease in respiratory complexes I and IV.
Molecular and cellular biology 2012;32(2):415-29.
2011: Alicia M Pickrell; milena pinto; Aline Hida; Carlos T Moraes
Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(48):17649-58.
2011: Tina Wenz; Xiao Wang; Matteo Marini; Carlos T Moraes
A metabolic shift induced by a PPAR panagonist markedly reduces the effects of pathogenic mitochondrial tRNA mutations.
Journal of cellular and molecular medicine 2011;15(11):2317-25.
2011: Xiao Wang; Carlos T Moraes
Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels.
Molecular oncology 2011;5(5):399-409.
2011: Francisca Diaz; Vineta Fellman; H Kotarsky; Carlos T Moraes
Mitochondrial disorders caused by mutations in respiratory chain assembly factors.
Seminars in fetal & neonatal medicine 2011;16(4):197-204.
2011: Adriana P Rebelo; Lloye M Dillon; Carlos T Moraes
Mitochondrial DNA transcription regulation and nucleoid organization.
Journal of inherited metabolic disease 2011;34(4):941-51.
2011: Alicia M Pickrell; milena pinto; Xiao Wang; Hirokazu Fukui; Carlos T Moraes
The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(27):9895-904.
2010: Siôn L Williams; Jia Huang; Yvonne Jemimah Edwards; Rick H Ulloa; Lloye M Dillon; Tomas A Prolla; Jeffery Vance; Carlos T Moraes; Stephan Zuchner
The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.
Cell metabolism 2010;12(6):675-82.
2010: Henna Tyynismaa; Christopher J Carroll; Nuno Raimundo; Sofia Ahola-Erkkilä; Tina Wenz; Heini Ruhanen; Kilian Guse; Akseli Hemminki; Katja E Peltola-Mjøsund; Valtteri Tulkki; Matej Oresic; Carlos T Moraes; Kirsi Pietiläinen; Iiris Hovatta; Anu Suomalainen
Mitochondrial myopathy induces a starvation-like response.
Human molecular genetics 2010;19(20):3948-58.
2010: Tina Wenz; Sion L Williams; Sandra R Bacman; Carlos T Moraes
Emerging therapeutic approaches to mitochondrial diseases.
Developmental disabilities research reviews 2010;16(2):219-29.
2010: Sandra R Bacman; S L Williams; S Garcia; Carlos T Moraes
Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.
Gene therapy 2010;17(6):713-20.
2010: Alicia Mae Pickrell; Carlos T Moraes
What role does mitochondrial stress play in neurodegenerative diseases?
Methods in molecular biology (Clifton, N.J.) 2010;648():63-78.
2009: Tina Wenz; Susana G Rossi; Richard L Rotundo; Bruce M Spiegelman; Carlos T Moraes
Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20405-10.
2009: Carlos T Moraes
Making the most of what you've got: optimizing residual OXPHOS function in mitochondrial diseases.
EMBO molecular medicine 2009;1(8-9):357-9.
2009: Adriana P Rebelo; Sion L Williams; Carlos T Moraes
In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions.
Nucleic acids research 2009;37(20):6701-15.
2009: Alicia M Pickrell; Hirokazu Fukui; Carlos T Moraes
The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation.
Journal of bioenergetics and biomembranes 2009;41(5):453-6.
2009: Sandra R Bacman; Sion L Williams; Carlos T Moraes
Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks.
Nucleic acids research 2009;37(13):4218-26.
2009: Tina Wenz; Corneliu Luca; Alessandra Torraco; Carlos T Moraes
mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription.
Cell metabolism 2009;9(6):499-511.
2009: Sarika Srivastava; Francisca Diaz; Luisa Iommarini; Karine Aure; Anne Lombes; Carlos T Moraes
PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.
Human molecular genetics 2009;18(10):1805-12.
2009: Tina Wenz; Francisca Diaz; Dayami Hernandez; Carlos T Moraes
Endurance exercise is protective for mice with mitochondrial myopathy.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(5):1712-9.
2009: Hirokazu Fukui; Carlos T Moraes
Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons.
Human molecular genetics 2009;18(6):1028-36.
2009: Uma Vempati; Xianlin Han; Carlos T Moraes
Lack of cytochrome c in mouse fibroblasts disrupts assembly/stability of respiratory complexes I and IV.
The Journal of biological chemistry 2009;284(7):4383-91.
2009: Alessandra Torraco; Francisca Diaz; Uma Vempati; Carlos T Moraes
Mouse models of oxidative phosphorylation defects: powerful tools to study the pathobiology of mitochondrial diseases.
Biochimica et biophysica acta 2009;1793(1):171-80.
2008: Uma Vempati; Alessandra Torraco; Carlos T Moraes
Mouse models of oxidative phosphorylation dysfunction and disease.
Methods (San Diego, Calif.) 2008;46(4):241-7.
2008: Tina Wenz; Francisca Diaz; Bruce M Spiegelman; Carlos T Moraes
Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype.
Cell metabolism 2008;8(3):249-56.
2008: Sofia Garcia; Francisca Diaz; Carlos T Moraes
A 3' UTR modification of the mitochondrial rieske iron sulfur protein in mice produces a specific skin pigmentation phenotype.
The Journal of investigative dermatology 2008;128(9):2343-5.
2008: Francisca Diaz; Carlos T Moraes
Mitochondrial biogenesis and turnover.
Cell calcium 2008;44(1):24-35.
2008: Hirokazu Fukui; Carlos T Moraes
The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?
Trends in neurosciences 2008;31(5):251-6.
2008: Mikhil Bamne; Michael E Talkowski; Carlos T Moraes; Stephen B Manuck; Robert E Ferrell; Kodavali V Chowdari; Vishwajit L Nimgaonkar
Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene.
Schizophrenia bulletin 2008;34(3):458-65.
2008: Francisca Diaz; S Garcia; Dayami Hernandez; A Regev; A Rebelo; Jose Oca-Cossio; Carlos T Moraes
Pathophysiology and fate of hepatocytes in a mouse model of mitochondrial hepatopathies.
Gut 2008;57(2):232-42.
2008: Corina van Waveren; Carlos T Moraes
Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system.
BMC genomics 2008;9():18.
2007: Sandra R Bacman; S L Williams; D Hernandez; Carlos T Moraes
Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.
Gene therapy 2007;14(18):1309-18.
2007: Hirokazu Fukui; Francisca Diaz; Sofia Garcia; Carlos T Moraes
Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14163-8.
2007: Eric L Bell; Tatyana A Klimova; James Eisenbart; Carlos T Moraes; Michael P Murphy; G R Scott Budinger; Navdeep S Chandel
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production.
The Journal of cell biology 2007;177(6):1029-36.
2007: Sarika Srivastava; John N Barrett; Carlos T Moraes
PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations.
Human molecular genetics 2007;16(8):993-1005.
2007: Hirokazu Fukui; Carlos T Moraes
Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates.
Human molecular genetics 2007;16(7):783-97.
2007: Uma Vempati; Francisca Diaz; Antoni Barrientos; Sonoko Narisawa; Abdul M Mian; José Luis Millán; Lawrence Boise; Carlos T Moraes
Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release.
Molecular and cellular biology 2007;27(5):1771-83.
2007: Joslyn K Brunelle; Emelyn H Shroff; Harris Perlman; Andreas Strasser; Carlos T Moraes; Richard A Flavell; Nika N Danial; Brian Keith; Craig Thompson; Navdeep S Chandel
Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death.
Molecular and cellular biology 2007;27(4):1222-35.
2007: Sandra R Bacman; Carlos T Moraes
Transmitochondrial technology in animal cells.
Methods in cell biology 2007;80():503-24.
2007: Sion L Williams; Carlos T Moraes
Microdissection and analytical PCR for the investigation of mtDNA lesions.
Methods in cell biology 2007;80():481-501.
2006: Danni L Meany; Bobby G Poe; Marian Navratil; Carlos T Moraes; Edgar A Arriaga
Superoxide released into the mitochondrial matrix.
Free radical biology & medicine 2006;41(6):950-9.
2006: Francisca Diaz; Hirokazu Fukui; Sofia Garcia; Carlos T Moraes
Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts.
Molecular and cellular biology 2006;26(13):4872-81.
2006: Sandra R Bacman; Walter G Bradley; Carlos T Moraes
Mitochondrial involvement in amyotrophic lateral sclerosis: trigger or target?
Molecular neurobiology 2006;33(2):113-31.
2006: Corina van Waveren; Yubo Sun; Herman S Cheung; Carlos T Moraes
Oxidative phosphorylation dysfunction modulates expression of extracellular matrix--remodeling genes and invasion.
Carcinogenesis 2006;27(3):409-18.
2005: Maria Pilar Bayona-Bafaluy; Bas Blits; Brendan J Battersby; Eric A Shoubridge; Carlos T Moraes
Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14392-7.
2005: Francisca Diaz; Christine K Thomas; Sofia Garcia; Dayami Hernandez; Carlos T Moraes
Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency.
Human molecular genetics 2005;14(18):2737-48.
2005: Sarika Srivastava; Carlos T Moraes
Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans.
Human molecular genetics 2005;14(7):893-902.
2005: Maria Pilar Bayona-Bafaluy; Stefan Müller; Carlos T Moraes
Fast adaptive coevolution of nuclear and mitochondrial subunits of ATP synthetase in orangutan.
Molecular biology and evolution 2005;22(3):716-24.
2005: Kunjan R Dave; Ami P Raval; Jesús Purroy; Ilias G Kirkinezos; Carlos T Moraes; Walter G Bradley; Miguel Perez
Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease.
Neurobiology of disease 2005;18(1):126-33.
2005: Ilias G Kirkinezos; Sandra R Bacman; Dayami Hernandez; Jose Oca-Cossio; Laura J Arias; Miguel Perez; Walter G Bradley; Carlos T Moraes
Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(1):164-72.
2004: Marilena D'Aurelio; Carl D Gajewski; Michael T Lin; William M Mauck; Leon Z Shao; Giorgio Lenaz; Carlos T Moraes; Giovanni Manfredi
Heterologous mitochondrial DNA recombination in human cells.
Human molecular genetics 2004;13(24):3171-9.
2004: Carlos T Moraes; Francisca Diaz; Antoni Barrientos
Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals.
Biochimica et biophysica acta 2004;1659(2-3):153-9.
2004: Corneliu C Luca; Byron Lam; Carlos T Moraes
Erythromycin as a potential precipitating agent in the onset of Leber's hereditary optic neuropathy.
Mitochondrion 2004;4(1):31-6.
2004: Rebeca Acín-Pérez; Maria Pilar Bayona-Bafaluy; Patricio Fernández-Silva; Raquel Moreno-Loshuertos; Acisclo Pérez-Martos; Claudio Bruno; Carlos T Moraes; José Antonio Enríquez
Respiratory complex III is required to maintain complex I in mammalian mitochondria.
Molecular cell 2004;13(6):805-15.
2004: Ilias G Kirkinezos; Dayami Hernandez; Walter G Bradley; Carlos T Moraes
An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment.
Journal of neurochemistry 2004;88(4):821-6.
2003: Carlos T Moraes; David P Atencio; Jose Oca-Cossio; Francisca Diaz
Techniques and pitfalls in the detection of pathogenic mitochondrial DNA mutations.
The Journal of molecular diagnostics : JMD 2003;5(4):197-208.
2003: Jose Oca-Cossio; Lesley Kenyon; Huiling Hao; Carlos T Moraes
Limitations of allotopic expression of mitochondrial genes in mammalian cells.
Genetics 2003;165(2):707-20.
2003: Maria Pilar Bayona-Bafaluy; Giovanni Manfredi; Carlos T Moraes
A chemical enucleation method for the transfer of mitochondrial DNA to rho(o) cells.
Nucleic acids research 2003;31(16):e98.
2003: Sandra R Bacman; David P Atencio; Carlos T Moraes
Decreased mitochondrial tRNALys steady-state levels and aminoacylation are associated with the pathogenic G8313A mitochondrial DNA mutation.
The Biochemical journal 2003;374(Pt 1):131-6.
2003: Ilias G Kirkinezos; Dayami Hernandez; Walter G Bradley; Carlos T Moraes
Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis.
Annals of neurology 2003;53(6):804-7.
2003: Giovanni Manfredi; Jennifer Q Kwong; José A Oca-Cossio; Markus Woischnik; Carl D Gajewski; Katherine Martushova; Marilena D'Aurelio; Avi Friedlich; Carlos T Moraes
BCL-2 improves oxidative phosphorylation and modulates adenine nucleotide translocation in mitochondria of cells harboring mutant mtDNA.
The Journal of biological chemistry 2003;278(8):5639-45.
2002: Francisca Diaz; Maria Pilar Bayona-Bafaluy; Michele Rana; Marialejandra Mora; Huiling Hao; Carlos T Moraes
Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control.
Nucleic acids research 2002;30(21):4626-33.
2002: Michelangelo Mancuso; Leonardo Salviati; Sabrina Sacconi; David Otaegui; Pilar Camaño; Alberto Marina; Sandra R Bacman; Carlos T Moraes; Jose R Carlo; M Garcia; M Garcia-Alvarez; L Monzon; Ali Naini; Michio Hirano; Eduardo Bonilla; A L Taratuto; Salvatore DiMauro; Tuan H Vu
Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA.
Neurology 2002;59(8):1197-202.
2002: Robert Lanza; Ho Yun Chung; James J Yoo; Peter J Wettstein; Catherine Blackwell; Nancy D Borson; Erik Hofmeister; Gunter Schuch; Shay Soker; Carlos T Moraes; Michael D West; Anthony Atala
Generation of histocompatible tissues using nuclear transplantation.
Nature biotechnology 2002;20(7):689-96.
2002: Markus Woischnik; Carlos T Moraes
Pattern of organization of human mitochondrial pseudogenes in the nuclear genome.
Genome research 2002;12(6):885-93.
2002: Carlos T Moraes
Studying mitochondria of animal cells.
Methods (San Diego, Calif.) 2002;26(4):291.
2002: Carlos T Moraes; Sarika Srivastava; Ilias G Kirkinezos; Jose Oca-Cossio; Corina van Waveren; Markus Woischnick; Francisca Diaz
Mitochondrial DNA structure and function.
International review of neurobiology 2002;53():3-23.
2001: S Srivastava; Carlos T Moraes
Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.
Human molecular genetics 2001;10(26):3093-9.
2001: Ilias G Kirkinezos; Carlos T Moraes
Reactive oxygen species and mitochondrial diseases.
Seminars in cell & developmental biology 2001;12(6):449-57.
2001: Carlos T Moraes
A helicase is born.
Nature genetics 2001;28(3):200-1.
2001: Carlos T Moraes
What regulates mitochondrial DNA copy number in animal cells?
Trends in genetics : TIG 2001;17(4):199-205.
2001: Guang-Ping Xu; Kunjan R Dave; Carlos T Moraes; Raul Busto; Thomas J Sick; Walter G Bradley; Miguel Perez
Dysfunctional mitochondrial respiration in the wobbler mouse brain.
Neuroscience letters 2001;300(3):141-4.
2001: Carlos T Moraes; R Dey; Antoni Barrientos
Transmitochondrial technology in animal cells.
Methods in cell biology 2001;65():397-412.
2000: Y Hu; Carlos T Moraes; Niramol Savaraj; Waldemar Priebe; Theodore J Lampidis
Rho(0) tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs.
Biochemical pharmacology 2000;60(12):1897-905.
2000: M Rana; I F M de Coo; Francisca Diaz; H J M Smeets; Carlos T Moraes
An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production.
Annals of neurology 2000;48(5):774-81.
2000: R Dey; Antoni Barrientos; Carlos T Moraes
Functional constraints of nuclear-mitochondrial DNA interactions in xenomitochondrial rodent cell lines.
The Journal of biological chemistry 2000;275(40):31520-7.
2000: Antoni Barrientos; S Müller; R Dey; J Wienberg; Carlos T Moraes
Cytochrome c oxidase assembly in primates is sensitive to small evolutionary variations in amino acid sequence.
Molecular biology and evolution 2000;17(10):1508-19.
2000: R Dey; Célia H Tengan; M P Morita; Beatriz H Kiyomoto; Carlos T Moraes
A novel myopathy-associated mitochondrial DNA mutation altering the conserved size of the tRNA(Gln) anticodon loop.
Neuromuscular disorders : NMD 2000;10(7):488-92.
2000: R Dey; Carlos T Moraes
Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells.
The Journal of biological chemistry 2000;275(10):7087-94.
2000: D Jarreta; Josefina Orús; Antoni Barrientos; Oscar Miró; Eulàlia Roig; Magda Heras; Carlos T Moraes; Francesc Cardellach; Jordi Casademont
Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy.
Cardiovascular research 2000;45(4):860-5.
2000: Robert Lanza; Jose B Cibelli; Francisca Diaz; Carlos T Moraes; Peter W Farin; Charlotte E Farin; C J Hammer; Michael D West; Philip Damiani
Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer.
Cloning 2000;2(2):79-90.
1999: L Chen; DM Segal; Carlos T Moraes; Deborah C Mash
Dopamine transporter mRNA in autopsy studies of chronic cocaine users.
Brain research. Molecular brain research 1999;73(1-2):181-5.
1999: Carlos T Moraes; Lesley Kenyon; Huiling Hao
Mechanisms of human mitochondrial DNA maintenance: the determining role of primary sequence and length over function.
Molecular biology of the cell 1999;10(10):3345-56.
1999: Antoni Barrientos; Carlos T Moraes
Titrating the effects of mitochondrial complex I impairment in the cell physiology.
The Journal of biological chemistry 1999;274(23):16188-97.
1999: Huiling Hao; L E Morrison; Carlos T Moraes
Suppression of a mitochondrial tRNA gene mutation phenotype associated with changes in the nuclear background.
Human molecular genetics 1999;8(6):1117-24.
1999: Alberto Pugliese; E Kawasaki; M Zeller; L Yu; S Babu; Michele Solimena; Carlos T Moraes; Massimo Pietropaolo; Robert P Friday; Massimo Trucco; Camillo Ricordi; M Allen; J A Noble; Henry A Erlich; George S Eisenbarth
Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism 1999;84(5):1722-8.
1998: M Zeviani; Carlos T Moraes; S DiMauro; H Nakase; E Bonilla; E A Schon; L P Rowland
Deletions of mitochondrial DNA in Kearns-Sayre syndrome. 1988.
Neurology 1998;51(6):1525 and 8 pages following.
1998: Antoni Barrientos; Carlos T Moraes
Simultaneous transfer of mitochondrial DNA and single chromosomes in somatic cells: a novel approach for the study of defects in nuclear-mitochondrial communication.
Human molecular genetics 1998;7(11):1801-8.
1998: E A Schon; E A Shoubridge; Carlos T Moraes
Cybrids in Alzheimer's disease: a cellular model of the disease?
Neurology 1998;51(1):326-7.
1998: Antoni Barrientos; Lesley Kenyon; Carlos T Moraes
Human xenomitochondrial cybrids. Cellular models of mitochondrial complex I deficiency.
The Journal of biological chemistry 1998;273(23):14210-7.
1998: Célia H Tengan; Carlos T Moraes
Duplication and triplication with staggered breakpoints in human mitochondrial DNA.
Biochimica et biophysica acta 1998;1406(1):73-80.
1998: Célia H Tengan; Beatriz H Kiyomoto; M S Rocha; V L Tavares; Alberto A Gabbai; Carlos T Moraes
Mitochondrial encephalomyopathy and hypoparathyroidism associated with a duplication and a deletion of mitochondrial deoxyribonucleic acid.
The Journal of clinical endocrinology and metabolism 1998;83(1):125-9.
1997: Huiling Hao; Carlos T Moraes
A disease-associated G5703A mutation in human mitochondrial DNA causes a conformational change and a marked decrease in steady-state levels of mitochondrial tRNA(Asn).
Molecular and cellular biology 1997;17(12):6831-7.
1997: Beatriz H Kiyomoto; Célia H Tengan; Carlos T Moraes; Acary S B Oliveira; Alberto A Gabbai
Mitochondrial DNA defects in Brazilian patients with chronic progressive external ophthalmoplegia.
Journal of the neurological sciences 1997;152(2):160-5.
1997: Ashok Verma; D A Piccoli; E Bonilla; G T Berry; S DiMauro; Carlos T Moraes
A novel mitochondrial G8313A mutation associated with prominent initial gastrointestinal symptoms and progressive encephaloneuropathy.
Pediatric research 1997;42(4):448-54.
1997: Célia H Tengan; Alberto A Gabbai; S Shanske; M Zeviani; Carlos T Moraes
Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle.
Mutation research 1997;379(1):1-11.
1997: Lesley Kenyon; Carlos T Moraes
Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9131-5.
1997: Huiling Hao; G Manfredi; Carlos T Moraes
Functional and structural features of a tandem duplication of the human mtDNA promoter region.
American journal of human genetics 1997;60(6):1363-72.
1997: DM Segal; Carlos T Moraes; Deborah C Mash
Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities.
Brain research. Molecular brain research 1997;45(2):335-9.
1996: Carlos T Moraes
Mitochondrial disorders.
Current opinion in neurology 1996;9(5):369-74.
1996: Célia H Tengan; Carlos T Moraes
Detection and analysis of mitochondrial DNA deletions by whole genome PCR.
Biochemical and molecular medicine 1996;58(1):130-4.
1996: Ashok Verma; Carlos T Moraes; Robert T Shebert; Walter G Bradley
A MERRF/PEO overlap syndrome associated with the mitochondrial DNA 3243 mutation.
Neurology 1996;46(5):1334-6.
1996: Huiling Hao; Carlos T Moraes
Functional and molecular mitochondrial abnormalities associated with a C --> T transition at position 3256 of the human mitochondrial genome. The effects of a pathogenic mitochondrial tRNA point mutation in organelle translation and RNA processing.
The Journal of biological chemistry 1996;271(4):2347-52.
1996: Carlos T Moraes; Eric A Schon
Detection and analysis of mitochondrial DNA and RNA in muscle by in situ hybridization and single-fiber PCR.
Methods in enzymology 1996;264():522-40.
1996: Giovanni Manfredi; Eric A Schon; Eduardo Bonilla; Carlos T Moraes; Sara Shanske; Salvatore DiMauro
Identification of a mutation in the mitochondrial tRNA(Cys) gene associated with mitochondrial encephalopathy.
Human mutation 1996;7(2):158-63.
1995: Giovanni Manfredi; Eric A Schon; Carlos T Moraes; Eduardo Bonilla; G T Berry; J T Sladky; Salvatore DiMauro
A new mutation associated with MELAS is located in a mitochondrial DNA polypeptide-coding gene.
Neuromuscular disorders : NMD 1995;5(5):391-8.
1995: Huiling Hao; Eduardo Bonilla; Giovanni Manfredi; Salvatore DiMauro; Carlos T Moraes
Segregation patterns of a novel mutation in the mitochondrial tRNA glutamic acid gene associated with myopathy and diabetes mellitus.
American journal of human genetics 1995;56(5):1017-25.
1995: Giovanni Manfredi; S Servidei; Eduardo Bonilla; Sara Shanske; Eric A Schon; Salvatore DiMauro; Carlos T Moraes
High levels of mitochondrial DNA with an unstable 260-bp duplication in a patient with a mitochondrial myopathy.
Neurology 1995;45(4):762-8.
1995: Carlos T Moraes; E Ricci; Eric A Schon; M Sciacco; Célia H Tengan; Eduardo Bonilla; H Hao; Salvatore DiMauro
Phenotype-genotype correlations in skeletal muscle of patients with mtDNA deletions.
Muscle & nerve. Supplement 1995;(3):S150-3.
1995: Carlos T Moraes; M Sciacco; E Ricci; Célia H Tengan; H Hao; Eduardo Bonilla; Eric A Schon; Salvatore DiMauro
Phenotype-genotype correlations in skeletal muscle of patients with mtDNA deletions.
Muscle & nerve. Supplement 1995;3():S150-3.
1994: V V Ionasescu; M Hart; S DiMauro; Carlos T Moraes
Clinical and morphologic features of a myopathy associated with a point mutation in the mitochondrial tRNA(Pro) gene.
Neurology 1994;44(5):975-7.
1994: V Petruzzella; Carlos T Moraes; Mary Sano; Eduardo Bonilla; Salvatore DiMauro; Eric A Schon
Extremely high levels of mutant mtDNAs co-localize with cytochrome c oxidase-negative ragged-red fibers in patients harboring a point mutation at nt 3243.
Human molecular genetics 1994;3(3):449-54.
1994: M Sciacco; Eduardo Bonilla; Eric A Schon; Salvatore DiMauro; Carlos T Moraes
Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy.
Human molecular genetics 1994;3(1):13-9.
1993: Carlos T Moraes; F Ciacci; Eduardo Bonilla; C Jansen; Michio Hirano; N Rao; R E Lovelace; Lewis P Rowland; Eric A Schon; Salvatore DiMauro
Two novel pathogenic mitochondrial DNA mutations affecting organelle number and protein synthesis. Is the tRNA(Leu(UUR)) gene an etiologic hot spot?
The Journal of clinical investigation 1993;92(6):2906-15.
1993: Salvatore DiMauro; Carlos T Moraes
Mitochondrial encephalomyopathies.
Archives of neurology 1993;50(11):1197-208.
1993: Carlos T Moraes; F Ciacci; Eduardo Bonilla; V Ionasescu; Eric A Schon; Salvatore DiMauro
A mitochondrial tRNA anticodon swap associated with a muscle disease.
Nature genetics 1993;4(3):284-8.
1993: Salvatore DiMauro; S Simonetti; X Chen; V Petruzzella; Michio Hirano; Sara Shanske; Carlos T Moraes; Eric A Schon
Mitochondrial dysfunction as a mechanism of CNS injury.
Research publications - Association for Research in Nervous and Mental Disease 1993;71():67-79.
1993: Carlos T Moraes; F Ciacci; G Silvestri; Sara Shanske; M Sciacco; Michio Hirano; Eric A Schon; Eduardo Bonilla; Salvatore DiMauro
Atypical clinical presentations associated with the MELAS mutation at position 3243 of human mitochondrial DNA.
Neuromuscular disorders : NMD 1993;3(1):43-50.
1992: G Silvestri; Carlos T Moraes; Sara Shanske; S J Oh; Salvatore DiMauro
A new mtDNA mutation in the tRNA(Lys) gene associated with myoclonic epilepsy and ragged-red fibers (MERRF).
American journal of human genetics 1992;51(6):1213-7.
1992: S Sancho; Carlos T Moraes; Kurenai Tanji; Armand F Miranda
Structural and functional mitochondrial abnormalities associated with high levels of partially deleted mitochondrial DNAs in somatic cell hybrids.
Somatic cell and molecular genetics 1992;18(5):431-42.
1992: Carlos T Moraes; E Ricci; V Petruzzella; Sara Shanske; Salvatore DiMauro; Eric A Schon; Eduardo Bonilla
Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions.
Nature genetics 1992;1(5):359-67.
1992: Eric A Schon; Y Koga; M Davidson; Carlos T Moraes; Michael P King
The mitochondrial tRNA(Leu)(UUR)) mutation in MELAS: a model for pathogenesis.
Biochimica et biophysica acta 1992;1101(2):206-9.
1992: Carlos T Moraes; E Ricci; Eduardo Bonilla; Salvatore DiMauro; Eric A Schon
The mitochondrial tRNA(Leu(UUR)) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): genetic, biochemical, and morphological correlations in skeletal muscle.
American journal of human genetics 1992;50(5):934-49.
1992: E Ciafaloni; E Ricci; Sara Shanske; Carlos T Moraes; G Silvestri; Michio Hirano; S Simonetti; Corrado Angelini; M A Donati; C Garcia
MELAS: clinical features, biochemistry, and molecular genetics.
Annals of neurology 1992;31(4):391-8.
1992: E Ricci; Carlos T Moraes; S Servidei; P Tonali; E Bonilla; S DiMauro
Disorders associated with depletion of mitochondrial DNA.
Brain pathology (Zurich, Switzerland) 1992;2(2):141-7.
1992: Eduardo Bonilla; M Sciacco; Kurenai Tanji; M Sparaco; V Petruzzella; Carlos T Moraes
New morphological approaches to the study of mitochondrial encephalomyopathies.
Brain pathology (Zurich, Switzerland) 1992;2(2):113-9.
1992: H J Tritschler; F Andreetta; Carlos T Moraes; Eduardo Bonilla; E Arnaudo; M J Danon; S Glass; Blas M. Zelaya; E Vamos; N Telerman-Toppet
Mitochondrial myopathy of childhood associated with depletion of mitochondrial DNA.
Neurology 1992;42(1):209-17.
1991: Carlos T Moraes; M Zeviani; Eric A Schon; R O Hickman; B W Vlcek; Salvatore DiMauro
Mitochondrial DNA deletion in a girl with manifestations of Kearns-Sayre and Lowe syndromes: an example of phenotypic mimicry?
American journal of medical genetics 1991;41(3):301-5.
1991: M L Zupanc; Carlos T Moraes; Sara Shanske; C B Langman; E Ciafaloni; Salvatore DiMauro
Deletion of mitochondrial DNA in patients with combined features of Kearns-Sayre and MELAS syndromes.
Annals of neurology 1991;29(6):680-3.
1991: E Arnaudo; M Dalakas; Sara Shanske; Carlos T Moraes; Salvatore DiMauro; Eric A Schon
Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy.
Lancet 1991;337(8740):508-10.
1991: Carlos T Moraes; Sara Shanske; H J Tritschler; June Aprille; F Andreetta; Eduardo Bonilla; Eric A Schon; Salvatore DiMauro
mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.
American journal of human genetics 1991;48(3):492-501.
1991: Carlos T Moraes; F Andreetta; Eduardo Bonilla; Sara Shanske; Salvatore DiMauro; Eric A Schon
Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region.
Molecular and cellular biology 1991;11(3):1631-7.
1991: Salvatore DiMauro; Carlos T Moraes; Sara Shanske; A Lombes; H Nakase; S Mita; H J Tritschler; Eduardo Bonilla; Armand F Miranda; Eric A Schon
Mitochondrial encephalomyopathies: biochemical approach.
Revue neurologique 1991;147(6-7):443-9.
1990: Salvatore DiMauro; Eduardo Bonilla; A Lombes; Sara Shanske; Carlo Minetti; Carlos T Moraes
Mitochondrial encephalomyopathies.
Neurologic clinics 1990;8(3):483-506.
1990: H Nakase; Carlos T Moraes; R Rizzuto; A Lombes; Salvatore DiMauro; Eric A Schon
Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis.
American journal of human genetics 1990;46(3):418-27.
1990: S Mita; R Rizzuto; Carlos T Moraes; Sara Shanske; E Arnaudo; G M Fabrizi; Y Koga; Salvatore DiMauro; Eric A Schon
Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA.
Nucleic acids research 1990;18(3):561-7.
1990: Sara Shanske; Carlos T Moraes; A Lombes; Armand F Miranda; Eduardo Bonilla; P Lewis; M A Whelan; C A Ellsworth; Salvatore DiMauro
Widespread tissue distribution of mitochondrial DNA deletions in Kearns-Sayre syndrome.
Neurology 1990;40(1):24-8.
1989: Carlos T Moraes; Salvatore DiMauro; M Zeviani; A Lombes; Sara Shanske; Armand F Miranda; H Nakase; Eduardo Bonilla; L C Werneck; S Servidei
Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome.
The New England journal of medicine 1989;320(20):1293-9.
1989: Carlos T Moraes; Eric A Schon; Salvatore DiMauro; Armand F Miranda
Heteroplasmy of mitochondrial genomes in clonal cultures from patients with Kearns-Sayre syndrome.
Biochemical and biophysical research communications 1989;160(2):765-71.
1989: Eric A Schon; R Rizzuto; Carlos T Moraes; H Nakase; M Zeviani; Salvatore DiMauro
A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA.
Science (New York, N.Y.) 1989;244(4902):346-9.
1989: Salvatore DiMauro; M Zeviani; Carlos T Moraes; H Nakase; R Rizzuto; A Lombes; Sara Shanske; Eric A Schon
Mitochondrial encephalomyopathies.
Progress in clinical and biological research 1989;306():117-28.
1988: M Zeviani; Carlos T Moraes; Salvatore DiMauro; H Nakase; Eduardo Bonilla; Eric A Schon; Lewis P Rowland
Deletions of mitochondrial DNA in Kearns-Sayre syndrome.
Neurology 1988;38(9):1339-46.
1988: Armand F Miranda; Eduardo Bonilla; G Martucci; Carlos T Moraes; Arthur P Hays; Salvatore DiMauro
Immunocytochemical study of dystrophin in muscle cultures from patients with Duchenne muscular dystrophy and unaffected control patients.
The American journal of pathology 1988;132(3):410-6.
1988: Eric A Schon; Eduardo Bonilla; A Lombes; Carlos T Moraes; H Nakase; R Rizzuto; M Zeviani; Salvatore DiMauro
Clinical and biochemical studies on cytochrome oxidase deficiencies.
Annals of the New York Academy of Sciences 1988;550():348-59.