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Françoise Moreau-Gachelin

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Maya Ridinger-Saison; Pauline Rimmelé; Emmanuel Barillot; Valentina Boeva; Isabelle Gallais; Philippe Hupé; Ivan Kulakovskiy; Patricia Legoix-Né; Benjamin Levavasseur; Françoise Moreau-Gachelin; François Morlé; Alain Nicolas; Caroline Paccard; Christel Guillouf
Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia.
Dorothée Buet; Nicole Denis; Isabelle Dusanter-Fourt; Isabelle Gallais; francois guillonneau; Christel Guillouf; Olivier Kosmider; Evelyne Lauret; Damarys Loew; Bérangère Lombard; Patrick Mayeux; Françoise Moreau-Gachelin
Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia.
Dorothée Selimoglu-Buet; Nicole Denis; Isabelle Gallais; Christel Guillouf; Françoise Moreau-Gachelin
Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells.

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All Publications

2012: Maya Ridinger-Saison; Pauline Rimmelé; Emmanuel Barillot; Valentina Boeva; Isabelle Gallais; Philippe Hupé; Ivan Kulakovskiy; Patricia Legoix-Né; Benjamin Levavasseur; Françoise Moreau-Gachelin; François Morlé; Alain Nicolas; Caroline Paccard; Christel Guillouf
Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia.
Nucleic acids research 2012;40(18):8927-41.
2012: Dorothée Buet; Nicole Denis; Isabelle Dusanter-Fourt; Isabelle Gallais; francois guillonneau; Christel Guillouf; Olivier Kosmider; Evelyne Lauret; Damarys Loew; Bérangère Lombard; Patrick Mayeux; Françoise Moreau-Gachelin
Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia.
Blood 2012;119(18):4228-41.
2012: Dorothée Selimoglu-Buet; Nicole Denis; Isabelle Gallais; Christel Guillouf; Françoise Moreau-Gachelin
Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells.
PloS one 2012;7(11):e49052.
2010: Pauline Rimmelé; Jun Komatsu; Philippe Hupé; Christophe Roulin; Emmanuel Barillot; Marie Dutreix; Emmanuel Conseiller; Aaron Bensimon; Françoise Moreau-Gachelin; Christel Guillouf
Spi-1/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage.
Cancer research 2010;70(17):6757-66.
2009: Gaëtan Juban; Guillaume Giraud; Boris Guyot; Stephane Belin; Jean-Jacques Diaz; Joëlle Starck; Christel Guillouf; Françoise Moreau-Gachelin; François Morlé
Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.
Molecular and cellular biology 2009;29(10):2852-64.
2009: Olivier Kosmider; Dorothée Buet; Isabelle Gallais; Nicole Denis; Françoise Moreau-Gachelin
Erythropoietin down-regulates stem cell factor receptor (Kit) expression in the leukemic proerythroblast: role of Lyn kinase.
PloS one 2009;4(5):e5721.
2008: Richard Monni; Lamya Haddaoui; Alexandra Naba; Isabelle Gallais; Monique Arpin; Patrick Mayeux; Françoise Moreau-Gachelin
Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia.
Blood 2008;111(6):3163-72.
2008: Françoise Moreau-Gachelin
Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation.
Retrovirology 2008;5():99.
2007: Olivier Kosmider; Nicole Denis; P Dubreuil; Françoise Moreau-Gachelin
Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate.
Oncogene 2007;26(26):3904-8.
2007: Pauline Rimmelé; Olivier Kosmider; Patrick Mayeux; Françoise Moreau-Gachelin; Christel Guillouf
Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation.
Blood 2007;109(7):3007-14.
2006: Françoise Moreau-Gachelin
Lessons from models of murine erythroleukemia to acute myeloid leukemia (AML): proof-of-principle of co-operativity in AML.
Haematologica 2006;91(12):1644-52.
2006: Christel Guillouf; Isabelle Gallais; Françoise Moreau-Gachelin
Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner.
The Journal of biological chemistry 2006;281(28):19145-55.
2006: Stéphane Barnache; Erwan Le Scolan; Olivier Kosmider; Nicole Denis; Françoise Moreau-Gachelin
Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene.
Oncogene 2006;25(9):1420-3.
2006: Olivier Kosmider; Françoise Moreau-Gachelin
From mice to human: the "two-hit model" of leukemogenesis.
Cell cycle (Georgetown, Tex.) 2006;5(6):569-70.
2006: Mikaël Le Clech; Elias Chalhoub; Christiane Dohet; Virginie Roure; Serge Fichelson; Françoise Moreau-Gachelin; Danièle Mathieu
PU.1/Spi-1 binds to the human TAL-1 silencer to mediate its activity.
Journal of molecular biology 2006;355(1):9-19.
2005: Olivier Kosmider; Nicole Denis; Catherine Lacout; William Vainchenker; Patrice Dubreuil; Françoise Moreau-Gachelin
Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.
Cancer cell 2005;8(6):467-78.
2005: Erwan Le Scolan; Dimitri Pchejetski; Yoshiko Banno; Nicole Denis; Patrick Mayeux; William Vainchenker; Thierry Levade; Françoise Moreau-Gachelin
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
Blood 2005;106(5):1808-16.
2005: Agnès Belly; Françoise Moreau-Gachelin; Rémy Sadoul; Yves Goldberg
Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads.
Neuroscience letters 2005;379(3):152-7.
2005: Yutaka Okuno; Gang Huang; Frank Rosenbauer; Erica K. Evans; Hanna S Radomska; Hiromi Iwasaki; Koichi Akashi; Françoise Moreau-Gachelin; Youlin Li; Pu Zhang; Berthold Göttgens; Daniel G Tenen
Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.
Molecular and cellular biology 2005;25(7):2832-45.
2004: Laurent Delva; Isabelle Gallais; Christel Guillouf; Nicole Denis; Christophe Orvain; Françoise Moreau-Gachelin
Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells.
Oncogene 2004;23(25):4389-99.
2004: Orianne Théoleyre; Mireille Deguillien; Madeleine Morinière; Joëlle Starck; Françoise Moreau-Gachelin; François Morlé; Faouzi Baklouti
Spi-1/PU.1 but not Fli-1 inhibits erythroid-specific alternative splicing of 4.1R pre-mRNA in murine erythroleukemia cells.
Oncogene 2004;23(4):920-7.
2002: Stéphane Giraudier; Hédia Chagraoui; Emiko Komura; Stéphane Barnache; Benoit Blanchet; Jean Pierre LeCouedic; David Smith; Frédéric Larbret; Anne-Laure Taksin; Françoise Moreau-Gachelin; Nicole Casadevall; Micheline Tulliez; Anne Hulin; Najet Debili; William Vainchenker
Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors.
Blood 2002;100(8):2932-40.
2001: Stéphane Barnache; Patrick Mayeux; B Payrastre; Françoise Moreau-Gachelin
Alterations of the phosphoinositide 3-kinase and mitogen-activated protein kinase signaling pathways in the erythropoietin-independent Spi-1/PU.1 transgenic proerythroblasts.
Blood 2001;98(8):2372-81.
2001: E L Scolan; Françoise Wendling; Stéphane Barnache; Nicole Denis; Micheline Tulliez; William Vainchenker; Françoise Moreau-Gachelin
Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts.
Oncogene 2001;20(39):5484-92.
2001: A Lerga; M Hallier; L Delva; Christophe Orvain; Isabelle Gallais; J Marie; Françoise Moreau-Gachelin
Identification of an RNA binding specificity for the potential splicing factor TLS.
The Journal of biological chemistry 2001;276(9):6807-16.
1999: Dominique Ray-Gallet; Françoise Moreau-Gachelin
Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.
FEBS letters 1999;464(3):164-8.
1998: Stéphane Barnache; Françoise Wendling; C Lacombe; Nicole Denis; Monique Titeux; William Vainchenker; Françoise Moreau-Gachelin
Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.
Oncogene 1998;16(23):2989-95.
1998: M Hallier; A Lerga; Stéphane Barnache; A Tavitian; Françoise Moreau-Gachelin
The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS.
The Journal of biological chemistry 1998;273(9):4838-42.
1996: D Ray-Gallet; A Tavitian; Françoise Moreau-Gachelin
An alternatively spliced isoform of the Spi-B transcription factor.
Biochemical and biophysical research communications 1996;223(2):257-63.
1996: M Hallier; A Tavitian; Françoise Moreau-Gachelin
The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb.
The Journal of biological chemistry 1996;271(19):11177-81.
1996: Françoise Moreau-Gachelin; Françoise Wendling; Thierry Molina; N Denis; Monique Titeux; G Grimber; Pascale Briand; W Vainchenker; A Tavitian
Spi-1/PU.1 transgenic mice develop multistep erythroleukemias.
Molecular and cellular biology 1996;16(5):2453-63.
1996: C Mao; D Ray-Gallet; A Tavitian; Françoise Moreau-Gachelin
Differential phosphorylations of Spi-B and Spi-1 transcription factors.
Oncogene 1996;12(4):863-73.
1995: H Chen; D Ray-Gallet; P Zhang; Christopher J Hetherington; D A Gonzalez; Dong-Er Zhang; Françoise Moreau-Gachelin; Daniel G Tenen
PU.1 (Spi-1) autoregulates its expression in myeloid cells.
Oncogene 1995;11(8):1549-60.
1995: D Ray-Gallet; C Mao; A Tavitian; Françoise Moreau-Gachelin
DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter.
Oncogene 1995;11(2):303-13.
1994: C Perez; E Coeffier; Françoise Moreau-Gachelin; Juana Wietzerbin; P D Benech
Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.
Molecular and cellular biology 1994;14(8):5023-31.
1994: M Dolores Delgado; M Hallier; P Meneceur; A Tavitian; Françoise Moreau-Gachelin
Inhibition of Friend cells proliferation by spi-1 antisense oligodeoxynucleotides.
Oncogene 1994;9(6):1723-7.
1992: D Ray; Rémy Bosselut; Jacques Ghysdael; M G Mattei; A Tavitian; Françoise Moreau-Gachelin
Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.
Molecular and cellular biology 1992;12(10):4297-304.
1990: V C Nguyen; D Ray; M S Gross; M F de Tand; J Frézal; Françoise Moreau-Gachelin
Localization of the human oncogene SPI1 on chromosome 11, region p11.22.
Human genetics 1990;84(6):542-6.
1990: D Ray; S Culine; A Tavitain; Françoise Moreau-Gachelin
The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors.
Oncogene 1990;5(5):663-8.
1990: Françoise Moreau-Gachelin; D Ray; NJ de Both; M J van der Feltz; P Tambourin; A Tavitian
Spi-1 oncogene activation in Rauscher and Friend murine virus-induced acute erythroleukemias.
Leukemia 1990;4(1):20-3.
1989: Françoise Moreau-Gachelin; D Ray; M G Mattei; P Tambourin; A Tavitian
The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias.
Oncogene 1989;4(12):1449-56.
1988: J Robert-Lézénès; P Meneceur; D Ray; Françoise Moreau-Gachelin
Protooncogene expression in normal, preleukemic, and leukemic murine erythroid cells and its relationship to differentiation and proliferation.
Cancer research 1988;48(14):3972-6.
1988: Françoise Moreau-Gachelin; A Tavitian; P Tambourin
Spi-1 is a putative oncogene in virally induced murine erythroleukaemias.
Nature 1988;331(6153):277-80.
1986: Françoise Moreau-Gachelin; L D'Auriol; J Robert-Lezenes; F Galibert; P Tambourin; A Tavitian
Analysis of integrated proviral DNA sequences with an octadecanucleotide probe designed for specific identification of spleen focus-forming virus in the mouse genome.
Journal of virology 1986;57(1):349-52.
1986: J Robert-Lezenes; Françoise Moreau-Gachelin; P Meneceur; P Tambourin
Retroviral endogenous transcripts related to the envelope gene of Friend spleen focus-forming virus in normal mouse tissues.
Archives of virology 1986;90(1-2):15-28.
1985: Françoise Moreau-Gachelin; J Robert-Lezenes; Françoise Wendling; A Tavitian; P Tambourin
Integration of spleen focus-forming virus proviruses in Friend tumor cells.
Journal of virology 1985;53(1):292-5.
1984: J Robert-Lezenes; Françoise Moreau-Gachelin; Françoise Wendling; P Tambourin; A Tavitian
Expression of c-ras and c-myc oncogenes in murine erythroleukemias induced by Friend viruses.
Leukemia research 1984;8(6):975-84.
1983: D Barbieri-Weill; D Mathieu-Mahul; F Gay; J Robert-Lezenes; Françoise Moreau-Gachelin; Françoise Wendling; C Lacombe; N Casadevall; P Tambourin; C J Larsen
Genesis of a new spleen focus-forming virus: possible role of MCF viruses.
Virology 1983;128(1):234-9.
1983: Françoise Moreau-Gachelin; J Robert-Lezenes; D Mathieu-Mahul; S Gisselbrecht; C J Larsen
Isolation and characterization of a gp 70+ non producer Friend tumor cell clone.
Biochimie 1983;65(4-5):259-66.
1981: Françoise Wendling; Françoise Moreau-Gachelin; P Tambourin
Emergence of tumorigenic cells during the course of Friend virus leukemias.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(6):3614-8.
1981: Françoise Moreau-Gachelin; Françoise Wendling; P Bucau-Varlet; M Charon; P Tambourin
Detection of tumorigenic cells in Friend virus-infected mice: an in vivo methodological investigation.
Journal of the National Cancer Institute 1981;66(6):1121-7.
1981: P Tambourin; Françoise Wendling; Françoise Moreau-Gachelin
Friend leukemia as a multiple-step disease.
Blood cells 1981;7(1):133-44.