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Emmanuel Moreau

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Publications

TOP 3
Nicolas Masurier; Anthony Ollivier; Daté Tétégan; Jean-Claude Teulade; Mounir Andaloussi; Antoine Bussière; Damien Canitrot; Olivier Chavignon; Jean-Michel Chezal; Eric Debiton; Marie-Josèphe Galmier; René C Gaudreault; Alicia Jacquemet; Jacques Lacroix; Emmanuel Moreau
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity.
Sébastien Fortin; Marie-France Côté; Lakshmi P Kotra; Jacques Lacroix; Emmanuel Moreau; Eric Petitclerc; Lianhu Wei; René C Gaudreault
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
Sébastien Fortin; Lakshmi P Kotra; Jacques Lacroix; Emmanuel Moreau; Eric Petitclerc; Lianhu Wei; Marie-France Côté; René C-Gaudreault
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.

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All Publications

2012: Nicolas Masurier; Anthony Ollivier; Daté Tétégan; Jean-Claude Teulade; Mounir Andaloussi; Antoine Bussière; Damien Canitrot; Olivier Chavignon; Jean-Michel Chezal; Eric Debiton; Marie-Josèphe Galmier; René C Gaudreault; Alicia Jacquemet; Jacques Lacroix; Emmanuel Moreau
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity.
European journal of medicinal chemistry 2012;52():137-50.
2011: Sébastien Fortin; Marie-France Côté; Lakshmi P Kotra; Jacques Lacroix; Emmanuel Moreau; Eric Petitclerc; Lianhu Wei; René C Gaudreault
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
European journal of medicinal chemistry 2011;46(11):5327-42.
2011: Sébastien Fortin; Lakshmi P Kotra; Jacques Lacroix; Emmanuel Moreau; Eric Petitclerc; Lianhu Wei; Marie-France Côté; René C-Gaudreault
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Journal of medicinal chemistry 2011;54(13):4559-80.
2011: Anna Trzeciakiewicz; Sébastien Fortin; Emmanuel Moreau; René C-Gaudreault; Jacques Lacroix; Christophe Chambon; Yves Communal; Jean-Michel Chezal; Elisabeth Miot-Noirault; Bernadette Bouchon; Françoise Degoul
Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.
Biochemical pharmacology 2011;81(9):1116-23.
2011: Sébastien Fortin; Bernadette Bouchon; Christophe Chambon; Jacques Lacroix; Emmanuel Moreau; Jean-Michel Chezal; Françoise Degoul; René C-Gaudreault
Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.
The Journal of pharmacology and experimental therapeutics 2011;336(2):460-7.
2010: Sébastien Fortin; Emmanuel Moreau; Jacques Lacroix; Marie-France Côté; Eric Petitclerc; René C-Gaudreault
Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.
European journal of medicinal chemistry 2010;45(7):2928-37.
2010: Jean-Michel Chezal; Jan Paeshuyse; Vincent Gaumet; Damien Canitrot; Aurélie Maisonial; Claire Lartigue; Alain Gueiffier; Emmanuel Moreau; Jean-Claude Teulade; Olivier Chavignon; Johan Neyts
Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus.
European journal of medicinal chemistry 2010;45(5):2044-7.
2010: Sébastien Fortin; Jacques Lacroix; Marie-France Côté; Emmanuel Moreau; Eric Petitclerc; René C-Gaudreault
Quick and simple detection technique to assess the binding of antimicrotubule agents to the colchicine-binding site.
Biological procedures online 2010;12(1):113-7.
2009: Sébastien Fortin; Lianhu Wei; Emmanuel Moreau; Philippe Labrie; Eric Petitclerc; Lakshmi P Kotra; René C-Gaudreault
Mechanism of action of N-phenyl-N'-(2-chloroethyl)ureas in the colchicine-binding site at the interface between alpha- and beta-tubulin.
Bioorganic & medicinal chemistry 2009;17(10):3690-7.
2008: Sébastien Fortin; Philippe Labrie; Emmanuel Moreau; Lianhu Wei; Lakshmi P Kotra; René C-Gaudreault
A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N'-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents.
Bioorganic & medicinal chemistry 2008;16(4):1914-26.
2007: Sébastien Fortin; Emmanuel Moreau; Jacques Lacroix; Jean-Claude Teulade; Alexandre Patenaude; René C-Gaudreault
N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
Bioorganic & medicinal chemistry letters 2007;17(7):2000-4.
2007: Sébastien Fortin; Emmanuel Moreau; Alexandre Patenaude; Michel Desjardins; Jacques Lacroix; Jean L C Rousseau; René C-Gaudreault
N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.
Bioorganic & medicinal chemistry 2007;15(3):1430-8.
2005: Emmanuel Moreau; Sébastien Fortin; Michel Desjardins; Jean L C Rousseau; Eric Petitclerc; René C-Gaudreault
Optimized N-phenyl-N'-(2-chloroethyl)ureas as potential antineoplastic agents: synthesis and growth inhibition activity.
Bioorganic & medicinal chemistry 2005;13(24):6703-12.
2005: Guillaume Morissette; Emmanuel Moreau; René C-Gaudreault; Francois Marceau
N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping.
Molecular pharmacology 2005;68(6):1576-89.
2004: Guillaume Morissette; Emmanuel Moreau; René C-Gaudreault; Francois Marceau
Massive cell vacuolization induced by organic amines such as procainamide.
The Journal of pharmacology and experimental therapeutics 2004;310(1):395-406.
2001: Jean-Michel Chezal; Emmanuel Moreau; G Delmas; Alain Gueiffier; Yves Blache; G Grassy; C Lartigue; Olivier Chavignon; Jean-Claude Teulade
Heterocyclization of functionalized vinylic derivatives of imidazo.
The Journal of organic chemistry 2001;66(20):6576-84.