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Stephen Beebe

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Wei Ren; Nova M Sain; Stephen J Beebe
Nanosecond pulsed electric fields (nsPEFs) activate intrinsic caspase-dependent and caspase-independent cell death in Jurkat cells.
Stephen J Beebe; Yeong-Jer Chen; Nova M Sain; Karl H Schoenbach; Shu Xiao
Transient features in nanosecond pulsed electric fields differentially modulate mitochondria and viability.
Wei Ren; Stephen J Beebe
An apoptosis targeted stimulus with nanosecond pulsed electric fields (nsPEFs) in E4 squamous cell carcinoma.

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All Publications

2012: Wei Ren; Nova M Sain; Stephen J Beebe
Nanosecond pulsed electric fields (nsPEFs) activate intrinsic caspase-dependent and caspase-independent cell death in Jurkat cells.
Biochemical and biophysical research communications 2012;421(4):808-12.
2012: Stephen J Beebe; Yeong-Jer Chen; Nova M Sain; Karl H Schoenbach; Shu Xiao
Transient features in nanosecond pulsed electric fields differentially modulate mitochondria and viability.
PloS one 2012;7(12):e51349.
2011: Wei Ren; Stephen J Beebe
An apoptosis targeted stimulus with nanosecond pulsed electric fields (nsPEFs) in E4 squamous cell carcinoma.
Apoptosis : an international journal on programmed cell death 2011;16(4):382-93.
2010: Jiahui Song; Ravindra P Joshi; Stephen J Beebe
Cellular apoptosis by nanosecond, high-intensity electric pulses: model evaluation of the pulsing threshold and extrinsic pathway.
Bioelectrochemistry (Amsterdam, Netherlands) 2010;79(2):179-86.
2010: Xinhua Chen; Juergen F Kolb; R James Swanson; Karl H Schoenbach; Stephen J Beebe
Apoptosis initiation and angiogenesis inhibition: melanoma targets for nanosecond pulsed electric fields.
Pigment cell & melanoma research 2010;23(4):554-63.
2010: Wentia E Ford; Wei Ren; Peter F Blackmore; Karl H Schoenbach; Stephen J Beebe
Nanosecond pulsed electric fields stimulate apoptosis without release of pro-apoptotic factors from mitochondria in B16f10 melanoma.
Archives of biochemistry and biophysics 2010;497(1-2):82-9.
2009: Richard Nuccitelli; Xinhua Chen; Andrei G Pakhomov; Wallace H Baldwin; Saleh Sheikh; Jennifer L Pomicter; Wei Ren; Christopher Osgood; R James Swanson; Juergen F Kolb; Stephen J Beebe; Karl H Schoenbach
A new pulsed electric field therapy for melanoma disrupts the tumor's blood supply and causes complete remission without recurrence.
International journal of cancer. Journal international du cancer 2009;125(2):438-45.
2009: Stephen J Beebe; Wentia E Ford; Wei Ren; Xinhua Chen; Karl H Schoenbach
Non-ionizing radiation with nanosecond pulsed electric fields as a cancer treatment: in vitro studies.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2009;2009():6509-12.
2008: Jue Zhang; Peter F Blackmore; Barbara Y Hargrave; Shu Xiao; Stephen J Beebe; Karl H Schoenbach
Nanosecond pulse electric field (nanopulse): a novel non-ligand agonist for platelet activation.
Archives of biochemistry and biophysics 2008;471(2):240-8.
2007: Nianyong Chen; Allen L Garner; George Chen; Yu Jing; Yuping Deng; R James Swanson; Juergen F Kolb; Stephen J Beebe; Ravindra P Joshi; Karl H Schoenbach
Nanosecond electric pulses penetrate the nucleus and enhance speckle formation.
Biochemical and biophysical research communications 2007;364(2):220-5.
2007: Allen L Garner; George Chen; Nianyong Chen; Viswanadham Sridhara; Juergen F Kolb; R James Swanson; Stephen J Beebe; Ravindra P Joshi; Karl H Schoenbach
Ultrashort electric pulse induced changes in cellular dielectric properties.
Biochemical and biophysical research communications 2007;362(1):139-44.
2007: Emily H Hall; Karl H Schoenbach; Stephen J Beebe
Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells.
Apoptosis : an international journal on programmed cell death 2007;12(9):1721-31.
2007: Ravindra P Joshi; A Nguyen; Viswanadham Sridhara; Q Hu; Richard Nuccitelli; Stephen J Beebe; Juergen F Kolb; Karl H Schoenbach
Simulations of intracellular calcium release dynamics in response to a high-intensity, ultrashort electric pulse.
Physical review. E, Statistical, nonlinear, and soft matter physics 2007;75(4 Pt 1):041920.
2007: Emily H Hall; Karl H Schoenbach; Stephen J Beebe
Nanosecond pulsed electric fields have differential effects on cells in the S-phase.
DNA and cell biology 2007;26(3):160-71.
2006: W Frey; J A White; R O Price; Peter F Blackmore; Ravindra P Joshi; Richard Nuccitelli; Stephen J Beebe; Karl H Schoenbach; Juergen F Kolb
Plasma membrane voltage changes during nanosecond pulsed electric field exposure.
Biophysical journal 2006;90(10):3608-15.
2006: Richard Nuccitelli; Uwe Pliquett; Xinhua Chen; Wentia Ford; R James Swanson; Stephen J Beebe; Juergen F Kolb; Karl H Schoenbach
Nanosecond pulsed electric fields cause melanomas to self-destruct.
Biochemical and biophysical research communications 2006;343(2):351-60.
2005: Emily H Hall; Karl H Schoenbach; Stephen J Beebe
Nanosecond pulsed electric fields (nsPEF) induce direct electric field effects and biological effects on human colon carcinoma cells.
DNA and cell biology 2005;24(5):283-91.
2005: Q Hu; S Viswanadham; Ravindra P Joshi; Karl H Schoenbach; Stephen J Beebe; Peter F Blackmore
Simulations of transient membrane behavior in cells subjected to a high-intensity ultrashort electric pulse.
Physical review. E, Statistical, nonlinear, and soft matter physics 2005;71(3 Pt 1):031914.
2005: Stephen J Beebe; Karl H Schoenbach
Nanosecond pulsed electric fields: a new stimulus to activate intracellular signaling.
Journal of biomedicine & biotechnology 2005;2005(4):297-300.
2005: Frank A Lattanzio; David A Tiangco; Christopher J Osgood; Stephen J Beebe; Julie A Kerry; Barbara Y Hargrave
Cocaine increases intracellular calcium and reactive oxygen species, depolarizes mitochondria, and activates genes associated with heart failure and remodeling.
Cardiovascular toxicology 2005;5(4):377-90.
2005: David A Tiangco; Frank A Lattanzio; Christopher J Osgood; Stephen J Beebe; Julie A Kerry; Barbara Y Hargrave
3,4-Methylenedioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cells.
Cardiovascular toxicology 2005;5(3):301-10.
2004: S L Taylor; Shun-Long Weng; P Fox; E Hakan Duran; Mahmood Morshedi; Sergio Oehninger; Stephen J Beebe
Somatic cell apoptosis markers and pathways in human ejaculated sperm: potential utility as indicators of sperm quality.
Molecular human reproduction 2004;10(11):825-34.
2004: Stephen J Beebe; Peter F Blackmore; Jody White; Ravindra P Joshi; Karl H Schoenbach
Nanosecond pulsed electric fields modulate cell function through intracellular signal transduction mechanisms.
Physiological measurement 2004;25(4):1077-93.
2004: Jody A White; Peter F Blackmore; Karl H Schoenbach; Stephen J Beebe
Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields.
The Journal of biological chemistry 2004;279(22):22964-72.
2004: Ravindra P Joshi; Q Hu; Karl H Schoenbach; Stephen J Beebe
Energy-landscape-model analysis for irreversibility and its pulse-width dependence in cells subjected to a high-intensity ultrashort electric pulse.
Physical review. E, Statistical, nonlinear, and soft matter physics 2004;69(5 Pt 1):051901.
2004: Weiqing Zhang; Gary Z Morris; Stephen J Beebe
Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells.
Protein expression and purification 2004;35(1):156-69.
2004: Nianyong Chen; Karl H Schoenbach; Juergen F Kolb; R James Swanson; Allen L Garner; Jing Yang; Ravindra P Joshi; Stephen J Beebe
Leukemic cell intracellular responses to nanosecond electric fields.
Biochemical and biophysical research communications 2004;317(2):421-7.
2004: Karl H Schoenbach; Ravindra Joshi; Juergen F Kolb; Stephen Buescher; Stephen J Beebe
Subcellular effects of nanosecond electrical pulses.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2004;7():5447-50.
2003: Martin Stacey; J Stickley; P Fox; V Statler; Karl H Schoenbach; Stephen J Beebe; S Buescher
Differential effects in cells exposed to ultra-short, high intensity electric fields: cell survival, DNA damage, and cell cycle analysis.
Mutation research 2003;542(1-2):65-75.
2003: Stephen J Beebe; Jody White; Peter F Blackmore; Yuping Deng; Kenneth D Somers; Karl H Schoenbach
Diverse effects of nanosecond pulsed electric fields on cells and tissues.
DNA and cell biology 2003;22(12):785-96.
2003: Sergio Oehninger; Mahmood Morshedi; Shun-Long Weng; Steve Taylor; Hakan E Duran; Stephen J Beebe
Presence and significance of somatic cell apoptosis markers in human ejaculated spermatozoa.
Reproductive biomedicine online 2003;7(4):469-76.
2003: Stephen J Beebe; Paula M Fox; Laura J Rec; E Lauren K Willis; Karl H Schoenbach
Nanosecond, high-intensity pulsed electric fields induce apoptosis in human cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1493-5.
2003: Jingdong Deng; Karl H Schoenbach; E Stephen Buescher; Pamela S Hair; Paula M Fox; Stephen J Beebe
The effects of intense submicrosecond electrical pulses on cells.
Biophysical journal 2003;84(4):2709-14.
2003: Barbara Y Hargrave; David A Tiangco; Frank A Lattanzio; Stephen J Beebe
Cocaine, not morphine, causes the generation of reactive oxygen species and activation of NF-kappaB in transiently cotransfected heart cells.
Cardiovascular toxicology 2003;3(2):141-51.
2002: Shun-Long Weng; Steven L Taylor; Mahmood Morshedi; Alessandro Schuffner; E Hakan Duran; Stephen J Beebe; Sergio Oehninger
Caspase activity and apoptotic markers in ejaculated human sperm.
Molecular human reproduction 2002;8(11):984-91.
2002: Gary Z Morris; Roy L Williams; Mark S Elliott; Stephen J Beebe
Resveratrol induces apoptosis in LNCaP cells and requires hydroxyl groups to decrease viability in LNCaP and DU 145 cells.
The Prostate 2002;52(4):319-29.
2002: Rana C Morris; Gary Z Morris; Weiqing Zhang; Merica Gellerman; Stephen J Beebe
Differential transcriptional regulation by the alpha- and gamma-catalytic subunit isoforms of cAMP-dependent protein kinase.
Archives of biochemistry and biophysics 2002;403(2):219-28.
2001: Karl H Schoenbach; Stephen J Beebe; E Stephen Buescher
Intracellular effect of ultrashort electrical pulses.
Bioelectromagnetics 2001;22(6):440-8.
1998: L K Parvathenani; E Stephen Buescher; Enrique Chacon-Cruz; Stephen J Beebe
Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3.
The Journal of biological chemistry 1998;273(12):6736-43.
1995: Donna H Wang; Russell L Prewitt; Stephen J Beebe
Regulation of PDGF-A: a possible mechanism for angiotensin II-induced vascular growth.
The American journal of physiology 1995;269(1 Pt 2):H356-64.
1994: Stephen J Beebe
The cAMP-dependent protein kinases and cAMP signal transduction.
Seminars in cancer biology 1994;5(4):285-94.
1993: Stephen J Beebe; P Salomonsky; C Holroyd; D Becker
Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(12):1005-12.
1992: Stephen J Beebe; P Salomonsky; T Jahnsen; Y Li
The C gamma subunit is a unique isozyme of the cAMP-dependent protein kinase.
The Journal of biological chemistry 1992;267(35):25505-12.
1992: Stephen J Beebe; L Leyton; D Burks; M Ishikawa; Thomas R Fuerst; Jurrien Dean; Patricia Saling
Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction.
Developmental biology 1992;151(1):48-54.
1992: M Morsy; K Takeuchi; R Kaufmann; Lucinda Veeck; Gary Hodgen; Stephen J Beebe
Preclinical models for human pre-embryo biopsy and genetic diagnosis. II. Polymerase chain reaction amplification of deoxyribonucleic acid from single lymphoblasts and blastomeres with mutation detection.
Fertility and sterility 1992;57(2):431-8.
1992: K Takeuchi; B A Sandow; M Morsy; R A Kaufmann; Stephen J Beebe; Gary Hodgen
Preclinical models for human pre-embryo biopsy and genetic diagnosis. I. Efficiency and normalcy of mouse pre-embryo development after different biopsy techniques.
Fertility and sterility 1992;57(2):425-30.
1992: K B Foss; Jacques Simard; D Bérubé; Stephen J Beebe; M Sandberg; K H Grzeschik; R Gagné; V Hansson; Tore Jahnsen
Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13.
Cytogenetics and cell genetics 1992;60(1):22-5.
1992: M K Thomas; Sharron H Francis; Stephen J Beebe; T W Gettys; Jackie D Corbin
Partial mapping of cyclic nucleotide sites and studies of regulatory mechanisms of phosphodiesterases using cyclic nucleotide analogues.
Advances in second messenger and phosphoprotein research 1992;25():45-53.
1991: B F Landmark; B Fauske; Winnie Eskild; Bjørn S Skålhegg; S M Lohmann; V Hansson; Tore Jahnsen; Stephen J Beebe
Identification, characterization, and hormonal regulation of 3', 5'-cyclic adenosine monophosphate-dependent protein kinases in rat Sertoli cells.
Endocrinology 1991;129(5):2345-54.
1991: Peter F Blackmore; Joseph Neulen; F Lattanzio; Stephen J Beebe
Cell surface-binding sites for progesterone mediate calcium uptake in human sperm.
The Journal of biological chemistry 1991;266(28):18655-9.
1990: D Becker; Stephen J Beebe; M Herlyn
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Oncogene 1990;5(8):1133-9.
1990: Stephen J Beebe; O Oyen; M Sandberg; A Frøysa; V Hansson; Tore Jahnsen
Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.
Molecular endocrinology (Baltimore, Md.) 1990;4(3):465-75.
1990: Peter F Blackmore; Stephen J Beebe; D R Danforth; N Alexander
Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.
The Journal of biological chemistry 1990;265(3):1376-80.
1989: Stephen J Beebe; D L Segaloff; D Burks; A Beasley-Leach; L E Limbird; Jackie D Corbin
Evidence that cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation causes pig ovarian granulosa cell differentiation, including increases in two type II subclasses of this kinase.
Biology of reproduction 1989;41(2):295-307.
1988: O Oyen; Winnie Eskild; Stephen J Beebe; V Hansson; Tore Jahnsen
Biphasic response to 3',5'-cyclic adenosine monophosphate (cAMP) at the messenger ribonucleic acid level for a regulatory subunit of cAMP-dependent protein kinase.
Molecular endocrinology (Baltimore, Md.) 1988;2(11):1070-6.
1988: O Oyen; M Sandberg; Winnie Eskild; Finn Olav Levy; G Knutsen; Stephen J Beebe; V Hansson; Tore Jahnsen
Differential regulation of messenger ribonucleic acids for specific subunits of cyclic adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase by cAMP in rat Sertoli cells.
Endocrinology 1988;122(6):2658-66.
1988: Winnie Eskild; O Oyen; Stephen J Beebe; Tore Jahnsen; V Hansson
Regulation of mRNA levels for cellular retinol binding protein in rat Sertoli cells by cyclic AMP and retinol.
Biochemical and biophysical research communications 1988;152(3):1504-10.
1988: Jackie D Corbin; Charles E Cobb; Stephen J Beebe; Daryl K Granner; S R Koch; T W Gettys; Peter F Blackmore; Sharron H Francis; J N Wells
Mechanism and function of cAMP- and cGMP-dependent protein kinases.
Advances in second messenger and phosphoprotein research 1988;21():75-86.
1988: O Oyen; M Sandberg; Finn Olav Levy; Kjetil Taskén; Stephen J Beebe; V Hansson; Tore Jahnsen
Molecular cloning and cell-specific expression of newly discovered subunits of cAMP-dependent protein kinases. Implications for different cellular responses to cAMP.
APMIS. Supplementum 1988;2():238-50.
1988: Jackie D Corbin; T W Gettys; Peter F Blackmore; Stephen J Beebe; Sharron H Francis; D B Glass; J B Redmon; V S Sheorain; L R Landiss
Purification and assay of cAMP, cGMP, and cyclic nucleotide analogs in cells treated with cyclic nucleotide analogs.
Methods in enzymology 1988;159():74-82.
1988: Stephen J Beebe; A Beasley-Leach; Jackie D Corbin
cAMP analogs used to study low-Km, hormone-sensitive phosphodiesterase.
Methods in enzymology 1988;159():531-40.
1988: Stephen J Beebe; P F Blackmore; T D Chrisman; J D Corbin
Use of synergistic pairs of site-selective cAMP analogs in intact cells.
Methods in enzymology 1988;159():118-39.
1987: Stephen J Beebe; S R Koch; D T Chu; Jackie D Corbin; Daryl K Granner
Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.
Molecular endocrinology (Baltimore, Md.) 1987;1(9):639-47.
1987: T W Gettys; Peter F Blackmore; J B Redmon; Stephen J Beebe; Jackie D Corbin
Short-term feedback regulation of cAMP by accelerated degradation in rat tissues.
The Journal of biological chemistry 1987;262(1):333-9.
1985: Stephen J Beebe; J B Redmon; Peter F Blackmore; Jackie D Corbin
Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis.
The Journal of biological chemistry 1985;260(29):15781-8.
1985: J D Corbin; Stephen J Beebe; P F Blackmore
cAMP-dependent protein kinase activation lowers hepatocyte cAMP.
The Journal of biological chemistry 1985;260(15):8731-5.
1984: A M Robinson-Steiner; Stephen J Beebe; S R Rannels; J D Corbin
Microheterogeneity of type II cAMP-dependent protein kinase in various mammalian species and tissues.
The Journal of biological chemistry 1984;259(16):10596-605.
1984: Stephen J Beebe; J D Corbin
Rat adipose tissue cAMP-dependent protein kinase: a unique form of type II.
Molecular and cellular endocrinology 1984;36(1-2):67-78.
1984: Stephen J Beebe; R Holloway; S R Rannels; J D Corbin
Two classes of cAMP analogs which are selective for the two different cAMP-binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes.
The Journal of biological chemistry 1984;259(6):3539-47.
1984: Stephen J Beebe; E M Reimann; K K Schlender
Purification and characterization of a cAMP- and Ca2+-calmodulin-independent glycogen synthase kinase from porcine renal cortex.
The Journal of biological chemistry 1984;259(3):1415-22.
1980: K K Schlender; Stephen J Beebe; James Willey; S A Lutz; E M Reimann
Isolation and characterization of cyclic AMP-independent glycogen synthase kinase from rat skeletal muscle.
Biochimica et biophysica acta 1980;615(2):324-40.