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Edgardo Moreno

Research Profile

Living Beings

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Brucellosis

Chemicals & Drugs

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Virulence

Anatomy

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Costa Rica

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Publications

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Elías Barquero-Calvo; Jean-Pierre Gorvel; Hubert Lepidi; Bernard Malissen; Marie Malissen; Anna Martirosyan; Alejandro Alfaro-Alarcón; Vilma Arce-Gorvel; Diana Ordoñez-Rueda; Edgardo Moreno
Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus.
Caterina Guzman-Verri; Gabriela Hernández-Mora; Juan Alberto Morales; Elías Baquero-Calvo; Esteban Chaves-Olarte; Rocío González Barrientos; Edgardo Moreno
Brucella ceti and brucellosis in cetaceans.
Raquel Conde-Álvarez; Vilma Arce-Gorvel; Elías Barquero-Calvo; José A Bengoechea; Klaus Brandenburg; Carlos Chacón-Díaz; Esteban Chaves-Olarte; María Jesús Grilló; Maite Iriarte; Roman Jerala; Enrique Llobet; Mateja Manček-Keber; Anna Martirosyan; Edgardo Moreno; Ignacio Moriyón; Leyre Palacios-Chaves; Kristine von Bargen; Jean-Pierre Gorvel
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition.

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All Publications

2013: Elías Barquero-Calvo; Jean-Pierre Gorvel; Hubert Lepidi; Bernard Malissen; Marie Malissen; Anna Martirosyan; Alejandro Alfaro-Alarcón; Vilma Arce-Gorvel; Diana Ordoñez-Rueda; Edgardo Moreno
Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus.
PLoS pathogens 2013;9(2):e1003167.
2012: Caterina Guzman-Verri; Gabriela Hernández-Mora; Juan Alberto Morales; Elías Baquero-Calvo; Esteban Chaves-Olarte; Rocío González Barrientos; Edgardo Moreno
Brucella ceti and brucellosis in cetaceans.
Frontiers in cellular and infection microbiology 2012;2():3.
2012: Raquel Conde-Álvarez; Vilma Arce-Gorvel; Elías Barquero-Calvo; José A Bengoechea; Klaus Brandenburg; Carlos Chacón-Díaz; Esteban Chaves-Olarte; María Jesús Grilló; Maite Iriarte; Roman Jerala; Enrique Llobet; Mateja Manček-Keber; Anna Martirosyan; Edgardo Moreno; Ignacio Moriyón; Leyre Palacios-Chaves; Kristine von Bargen; Jean-Pierre Gorvel
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition.
PLoS pathogens 2012;8(5):e1002675.
2012: María Jesús Grilló; JOSE M BLASCO; Jean-Pierre Gorvel; Ignacio Moriyón; Edgardo Moreno
What have we learned from brucellosis in the mouse model?
Veterinary research 2012;43(1):29.
2011: Edgardo Moreno; José María Gutiérrez; Esteban Chaves-Olarte
The struggle of neglected scientific groups: ten years of NeTropica efforts to promote research in tropical diseases in Central America.
PLoS neglected tropical diseases 2011;5(7):e1055.
2011: Carlos Chacón-Díaz; Melissa Muñoz-Rodríguez; Elías Barquero-Calvo; Caterina Guzman-Verri; Esteban Chaves-Olarte; María Jesús Grilló; Edgardo Moreno
The use of green fluorescent protein as a marker for Brucella vaccines.
Vaccine 2011;29(3):577-82.
2011: Leyre Palacios-Chaves; Raquel Conde-Álvarez; Yolanda Gil-Ramírez; Amaia Zúñiga-Ripa; Elías Barquero-Calvo; Carlos Chacón-Díaz; Esteban Chaves-Olarte; Vilma Arce-Gorvel; Jean-Pierre Gorvel; Edgardo Moreno; María J de Miguel; María Jesús Grilló; Ignacio Moriyón; Maite Iriarte
Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern.
PloS one 2011;6(1):e16030.
2010: Carola Martínez-Núñez; Pamela Altamirano-Silva; Francisco Alvarado-Guillén; Edgardo Moreno; Caterina Guzman-Verri; Esteban Chaves-Olarte
The two-component system BvrR/BvrS regulates the expression of the type IV secretion system VirB in Brucella abortus.
Journal of bacteriology 2010;192(21):5603-8.
2010: Rocío González Barrientos; Juan Alberto Morales; G Hernández-Mora; E Barquero-Calvo; Caterina Guzman-Verri; Esteban Chaves-Olarte; Edgardo Moreno
Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti.
Journal of comparative pathology 2010;142(4):347-52.
2010: Bruno Lomonte; Yamileth Angulo; Edgardo Moreno
Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from viperidae snake venoms: biomimetic activities and potential applications.
Current pharmaceutical design 2010;16(28):3224-30.
2010: Julie Lamontagne; Maxime Béland; Anik Forest; Alexandra Côté-Martin; Najib Nassif; Fadi Tomaki; Ignacio Moriyón; Edgardo Moreno; Eustache Paramithiotis
Proteomics-based confirmation of protein expression and correction of annotation errors in the Brucella abortus genome.
BMC genomics 2010;11():300.
2009: Gabriela Hernández-Mora; Charles A Manire; Rocío González Barrientos; Elías Barquero-Calvo; Caterina Guzman-Verri; Lydia Staggs; Rachel Thompson; Esteban Chaves-Olarte; Edgardo Moreno
Serological diagnosis of Brucella infections in odontocetes.
Clinical and vaccine immunology : CVI 2009;16(6):906-15.
2009: Julie Lamontagne; Anik Forest; Elena Marazzo; François Denis; Heather Butler; Jean-François Michaud; Lyne Boucher; Ida Pedro; Annie Villeneuve; Dmitri Sitnikov; Karine Trudel; Najib Nassif; Djamila Boudjelti; Fadi Tomaki; Esteban Chaves-Olarte; Caterina Guzman-Verri; Sylvain Brunet; Alexandra Côté-Martin; Joanna Hunter; Edgardo Moreno; Eustache Paramithiotis
Intracellular adaptation of Brucella abortus.
Journal of proteome research 2009;8(3):1594-609.
2009: Elías Barquero-Calvo; Raquel Conde-Alvarez; Carlos Chacón-Díaz; Lucía Quesada-Lobo; Anna Martirosyan; Caterina Guzman-Verri; Maite Iriarte; Mateja Mancek-Keber; Roman Jerala; Jean-Pierre Gorvel; Ignacio Moriyón; Edgardo Moreno; Esteban Chaves-Olarte
The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens.
PloS one 2009;4(6):e5893.
2008: Gabriela Hernández-Mora; Rocío González Barrientos; Juan Alberto Morales; Esteban Chaves-Olarte; Caterina Guzman-Verri; Elías Barquero-Calvo; Elías Baquero-Calvo; María-Jesús De-Miguel; Clara-María Marín; JOSE M BLASCO; Edgardo Moreno
Neurobrucellosis in stranded dolphins, Costa Rica.
Emerging infectious diseases 2008;14(9):1430-3.
2008: Edgardo Moreno; José-María Gutiérrez
Ten simple rules for aspiring scientists in a low-income country.
PLoS computational biology 2008;4(4):e1000024.
2008: Edgardo Moreno; Bruno Lomonte; José-María Gutiérrez
Computational biology in Costa Rica: the role of a small country in the global context of bioinformatics.
PLoS computational biology 2008;4(3):e1000040.
2007: Lorea Manterola; Caterina Guzman-Verri; Esteban Chaves-Olarte; Elías Barquero-Calvo; María J de Miguel; Ignacio Moriyón; María Jesús Grilló; Ignacio Lopez-Goñi; Edgardo Moreno
BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence.
Infection and immunity 2007;75(10):4867-74.
2007: Julie Lamontagne; Heather Butler; Esteban Chaves-Olarte; Joanna Hunter; Michael Schirm; Caroline Paquet; Mei Tian; Paul Kearney; Lyes Hamaidi; Daniel Chelsky; Ignacio Moriyón; Edgardo Moreno; Eustache Paramithiotis
Extensive cell envelope modulation is associated with virulence in Brucella abortus.
Journal of proteome research 2007;6(4):1519-29.
2007: Elías Barquero-Calvo; Esteban Chaves-Olarte; David S Weiss; Caterina Guzman-Verri; Carlos Chacón-Díaz; Alexandra Rucavado; Ignacio Moriyón; Edgardo Moreno
Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection.
PloS one 2007;2(7):e631.
2006: Nicolas Lapaque; Frédérique Forquet; Chantal de Chastellier; Zohar Mishal; Gilles Jolly; Edgardo Moreno; Ignacio Moriyon; John Edward Heuser; Hai-Tao He; Jean-Pierre Gorvel
Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts.
Cellular microbiology 2006;8(2):197-206.
2005: Lorea Manterola; Ignacio Moriyón; Edgardo Moreno; Alberto Sola-Landa; David S Weiss; Michel H J Koch; Jörg Howe; Klaus Brandenburg; Ignacio Lopez-Goñi
The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides.
Journal of bacteriology 2005;187(16):5631-9.
2005: Carlos Santamaría; Silda Larios; Yamileth Angulo; Javier Pizarro-Cerda; Jean-Pierre Gorvel; Edgardo Moreno; Bruno Lomonte
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region.
Toxicon : official journal of the International Society on Toxinology 2005;45(7):807-15.
2005: Beatriz Arellano-Reynoso; Nicolas Lapaque; Suzana P Salcedo; Gabriel Briones; Andrés E Ciocchini; Rodolfo A Ugalde; Edgardo Moreno; Ignacio Moriyón; Jean-Pierre Gorvel
Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival.
Nature immunology 2005;6(6):618-25.
2005: Carlos Santamaría; Silda Larios; Steve Quirós; Javier Pizarro-Cerda; Jean-Pierre Gorvel; Bruno Lomonte; Edgardo Moreno
Bactericidal and antiendotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2.
Antimicrobial agents and chemotherapy 2005;49(4):1340-5.
2005: Nicolas Lapaque; Ignacio Moriyon; Edgardo Moreno; Jean-Pierre Gorvel
Brucella lipopolysaccharide acts as a virulence factor.
Current opinion in microbiology 2005;8(1):60-6.
2004: Ignacio Moriyón; María Jesús Grilló; Daniel Monreal; David González; Clara María Marín; Ignacio Lopez-Goñi; Raul Carlos Mainar-Jaime; Edgardo Moreno; José María Blasco
Rough vaccines in animal brucellosis: structural and genetic basis and present status.
Veterinary research 2004;35(1):1-38.
2003: Jean Celli; Chantal de Chastellier; Don-Marc Franchini; Javier Pizarro-Cerda; Edgardo Moreno; Jean-Pierre Gorvel
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum.
The Journal of experimental medicine 2003;198(4):545-56.
2003: Esteban Chaves-Olarte; Enrique Freer; Andrea Parra; Caterina Guzman-Verri; Edgardo Moreno; Monica Thelestam
R-Ras glucosylation and transient RhoA activation determine the cytopathic effect produced by toxin B variants from toxin A-negative strains of Clostridium difficile.
The Journal of biological chemistry 2003;278(10):7956-63.
2002: Ignacio Lopez-Goñi; Caterina Guzman-Verri; Lorea Manterola; Alberto Sola-Landa; Ignacio Moriyón; Edgardo Moreno
Regulation of Brucella virulence by the two-component system BvrR/BvrS.
Veterinary microbiology 2002;90(1-4):329-39.
2002: Jean-Pierre Gorvel; Edgardo Moreno
Brucella intracellular life: from invasion to intracellular replication.
Veterinary microbiology 2002;90(1-4):281-97.
2002: Edgardo Moreno; Axel Cloeckaert; Ignacio Moriyón
Brucella evolution and taxonomy.
Veterinary microbiology 2002;90(1-4):209-27.
2002: Edgardo Moreno
Brucellosis in Central America.
Veterinary microbiology 2002;90(1-4):31-8.
2002: Esteban Chaves-Olarte; Caterina Guzman-Verri; Stéphane Méresse; Michel Desjardins; Javier Pizarro-Cerdá; Jenny Badilla; Jean-Pierre Gorvel; Edgardo Moreno
Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking.
Cellular microbiology 2002;4(10):663-76.
2002: Caterina Guzman-Verri; Lorea Manterola; Alberto Sola-Landa; A Parra; A Cloeckaert; J Garin; Jean-Pierre Gorvel; Ignacio Moriyon; Edgardo Moreno; I Lopez-Goni
The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12375-80.
2002: Edgardo Moreno; Ignacio Moriyon
Brucella melitensis: a nasty bug with hidden credentials for virulence.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):1-3.
2001: Caterina Guzman-Verri; Esteban Chaves-Olarte; Christoph von Eichel-Streiber; Ignacio Lopez-Goñi; Monica Thelestam; Staffan Arvidson; Jean-Pierre Gorvel; Edgardo Moreno
GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42.
The Journal of biological chemistry 2001;276(48):44435-43.
2001: N Rojas; O Zamora; J Cascante; D Garita; Edgardo Moreno
Comparison of the antibody response in adult cattle against different epitopes of Brucella abortus lipopolysaccharide.
Journal of veterinary medicine. B, Infectious diseases and veterinary public health 2001;48(8):623-9.
2001: Caterina Guzman-Verri; Esteban Chaves-Olarte; F García; Staffan Arvidson; Edgardo Moreno
In vivo proteolytic degradation of the Escherichia coli acyltransferase HlyC.
The Journal of biological chemistry 2001;276(20):16660-6.
2000: C Forestier; F Deleuil; Nicolas Lapaque; Edgardo Moreno; Jean-Pierre Gorvel
Brucella abortus lipopolysaccharide in murine peritoneal macrophages acts as a down-regulator of T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5202-10.
2000: J Velasco; José Antonio Bengoechea; Klaus Brandenburg; B Lindner; U Seydel; David González; Ulrich Zähringer; Edgardo Moreno; Ignacio Moriyón
Brucella abortus and its closest phylogenetic relative, Ochrobactrum spp., differ in outer membrane permeability and cationic peptide resistance.
Infection and immunity 2000;68(6):3210-8.
1999: Bruno Lomonte; Javier Pizarro-Cerdá; Yamileth Angulo; Jean-Pierre Gorvel; Edgardo Moreno
Tyr-->Trp-substituted peptide 115-129 of a Lys49 phospholipase A(2) expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect.
Biochimica et biophysica acta 1999;1461(1):19-26.
1999: C Forestier; Edgardo Moreno; Stéphane Méresse; Armelle Phalipon; D Olive; Philippe Sansonetti; Jean-Pierre Gorvel
Interaction of Brucella abortus lipopolysaccharide with major histocompatibility complex class II molecules in B lymphocytes.
Infection and immunity 1999;67(8):4048-54.
1999: C Forestier; Edgardo Moreno; Javier Pizarro-Cerda; Jean-Pierre Gorvel
Lysosomal accumulation and recycling of lipopolysaccharide to the cell surface of murine macrophages, an in vitro and in vivo study.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6784-91.
1998: Javier Pizarro-Cerdá; Stéphane Méresse; Robert Parton; G van der Goot; Alberto Sola-Landa; I Lopez-Goñi; Edgardo Moreno; Jean-Pierre Gorvel
Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes.
Infection and immunity 1998;66(12):5711-24.
1998: Alberto Sola-Landa; Javier Pizarro-Cerdá; María Jesús Grilló; Edgardo Moreno; Ignacio Moriyón; José María Blasco; Jean-Pierre Gorvel; Ignacio Lopez-Goñi
A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence.
Molecular microbiology 1998;29(1):125-38.
1998: Javier Pizarro-Cerdá; Edgardo Moreno; V Sanguedolce; J L Mege; Jean-Pierre Gorvel
Virulent Brucella abortus prevents lysosome fusion and is distributed within autophagosome-like compartments.
Infection and immunity 1998;66(5):2387-92.
1998: L Páramo; Bruno Lomonte; Javier Pizarro-Cerdá; José Antonio Bengoechea; Jean-Pierre Gorvel; Edgardo Moreno
Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom--synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region.
European journal of biochemistry / FEBS 1998;253(2):452-61.
1997: Edgardo Moreno
In search of a bacterial species definition.
Revista de biología tropical 1997;45(2):753-71.
1996: Alexandra Rucavado; Edgardo Moreno; José María Gutiérrez
Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1996;29(10):1337-40.
1996: E Freer; Edgardo Moreno; Ignacio Moriyón; Javier Pizarro-Cerdá; A Weintraub; Jean-Pierre Gorvel
Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts.
Journal of bacteriology 1996;178(20):5867-76.
1996: V Aragón; R Díaz; Edgardo Moreno; Ignacio Moriyón
Characterization of Brucella abortus and Brucella melitensis native haptens as outer membrane O-type polysaccharides independent from the smooth lipopolysaccharide.
Journal of bacteriology 1996;178(4):1070-9.
1995: C Jiménez; J A Bonilla; Gaby Dolz; L R Rodriguez; L Herrero; E Bolaños; M R Cortéz; Edgardo Moreno
Bovine leukaemia-virus infection in Costa Rica.
Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B 1995;42(7):385-90.
1995: E Freer; N Rojas; A Weintraub; A A Lindberg; Edgardo Moreno
Heterogeneity of Brucella abortus lipopolysaccharides.
Research in microbiology 1995;146(7):569-78.
1995: G Martínez de Tejada; Javier Pizarro-Cerdá; Edgardo Moreno; Ignacio Moriyón
The outer membranes of Brucella spp. are resistant to bactericidal cationic peptides.
Infection and immunity 1995;63(8):3054-61.
1994: J M Escola; Edgardo Moreno; Philippe Chavrier; Jean-Pierre Gorvel
The O-chain of Brucella abortus lipopolysaccharide induces SDS-resistant MHC class II molecules in mouse B cells.
Biochemical and biophysical research communications 1994;203(2):1230-6.
1994: N Rojas; E Freer; A Weintraub; M Ramirez; S Lind; Edgardo Moreno
Immunochemical identification of Brucella abortus lipopolysaccharide epitopes.
Clinical and diagnostic laboratory immunology 1994;1(2):206-13.
1993: Efrén Díaz-Aparicio; V Aragón; Clara María Marín; B Alonso; M Font; Edgardo Moreno; S Pérez-Ortiz; José María Blasco; R Díaz; Ignacio Moriyón
Comparative analysis of Brucella serotype A and M and Yersinia enterocolitica O:9 polysaccharides for serological diagnosis of brucellosis in cattle, sheep, and goats.
Journal of clinical microbiology 1993;31(12):3136-41.
1992: C Valiente; Edgardo Moreno; A Sittenfeld; Bruno Lomonte; José María Gutiérrez
An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes.
Toxicon : official journal of the International Society on Toxinology 1992;30(8):815-23.
1990: Edgardo Moreno; Erko Stackebrandt; M Dorsch; J Wolters; M Busch; H Mayer
Brucella abortus 16S rRNA and lipid A reveal a phylogenetic relationship with members of the alpha-2 subdivision of the class Proteobacteria.
Journal of bacteriology 1990;172(7):3569-76.
1989: M Dorsch; Edgardo Moreno; Erko Stackebrandt
Nucleotide sequence of the 16S rRNA from Brucella abortus.
Nucleic acids research 1989;17(4):1765.
1988: A Sittenfeld; Edgardo Moreno
A sensitive blotting system for detection of alpha-fetoprotein variants with monoclonal and polyclonal antibodies.
Journal of immunological methods 1988;106(1):19-26.
1988: Edgardo Moreno; José María Gutiérrez
Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):403-9.
1988: Edgardo Moreno; A Alape; M Sánchez; José María Gutiérrez
A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):363-71.
1987: Edgardo Moreno; H Mayer; I Moriyon
Characterization of a native polysaccharide hapten from Brucella melitensis.
Infection and immunity 1987;55(11):2850-3.
1987: Bruno Lomonte; Edgardo Moreno; José María Gutiérrez
Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms.
Toxicon : official journal of the International Society on Toxinology 1987;25(9):947-55.