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Silvia Moreno

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TOP 3
Silvia N J Moreno; Roberto Docampo
Polyphosphate and its diverse functions in host cells and pathogens.
Guobin Cai; Lisheng Deng; Silvia N J Moreno; Boris Striepen; Jian Xue; Yongcheng Song
Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Marion Recher; Sergio H Szajnman; Alejandro P Barboza; Roberto Docampo; Mariana Ferrer-Casal; Melina Galizzi; Zhu-Hong Li; Silvia N J Moreno; Juan B Rodriguez
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.

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All Publications

2013: Silvia N J Moreno; Roberto Docampo
Polyphosphate and its diverse functions in host cells and pathogens.
PLoS pathogens 2013;9(5):e1003230.
2013: Guobin Cai; Lisheng Deng; Silvia N J Moreno; Boris Striepen; Jian Xue; Yongcheng Song
Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Bioorganic & medicinal chemistry letters 2013;23(7):2158-61.
2013: Marion Recher; Sergio H Szajnman; Alejandro P Barboza; Roberto Docampo; Mariana Ferrer-Casal; Melina Galizzi; Zhu-Hong Li; Silvia N J Moreno; Juan B Rodriguez
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.
European journal of medicinal chemistry 2013;60():431-40.
2013: Guozhong Huang; Silvia N J Moreno; Andrew P Thomas; Paula J Bartlett; Roberto Docampo
Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1887-92.
2012: Zhu-Hong Li; Roxana Cintrón; Noah A Koon; Silvia N J Moreno
The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase.
Biochemistry 2012;51(38):7533-40.
2012: Sergio H Szajnman; Valeria S Rosso; Alyssa Smith; Roberto Docampo; Leena Malayil; Silvia N J Moreno; Juan B Rodriguez
1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase.
Organic & biomolecular chemistry 2012;10(7):1424-33.
2011: Douglas A Pace; Roxana Cintron; Melissa D Docampo; Jianmin Fang; Silvia N J Moreno
Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of PP(i) in glycolysis for Toxoplasma gondii.
The Biochemical journal 2011;440(2):229-40.
2011: Roberto Docampo; Silvia N J Moreno
Acidocalcisomes.
Cell calcium 2011;50(2):113-9.
2011: Sethu C Nair; Yongcheng Song; Angelika Strurm; Sandeep Sundriyal; Angelika Sturm; Justin L Anglin; Carrie F Brooks; Christopher D Goodman; Geoffrey I McFadden; Silvia N J Moreno; Boris Striepen
Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii.
The Journal of experimental medicine 2011;208(7):1547-59.
2011: Maria E Francia; Sarah Wicher; Douglas A Pace; Jack Sullivan; Silvia N J Moreno; Gustavo Arrizabalaga
A Toxoplasma gondii protein with homology to intracellular type Na⁺/H⁺ exchangers is important for osmoregulation and invasion.
Experimental cell research 2011;317(10):1382-96.
2011: Valeria S Rosso; Sergio H Szajnman; Leena Malayil; Melina Galizzi; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Bioorganic & medicinal chemistry 2011;19(7):2211-7.
2011: Peggy J Rooney; Lawrence Ayong; Crystal M Tobin; Silvia N J Moreno; Laura J Knoll
TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii.
Molecular and biochemical parasitology 2011;176(2):121-6.
2011: Silvia N J Moreno; Lawrence Ayong; Douglas A Pace
Calcium storage and function in apicomplexan parasites.
Essays in biochemistry 2011;51():97-110.
2011: Roberto Docampo; Veronica Jimenez; Sharon King-Keller; Zhu-hong Li; Silvia N J Moreno
The role of acidocalcisomes in the stress response of Trypanosoma cruzi.
Advances in parasitology 2011;75():307-24.
2011: Peter Rohloff; Kildare Miranda; Juliany C F Rodrigues; Jianmin Fang; Melina Galizzi; Helmut Plattner; Joachim Hentschel; Silvia N J Moreno
Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii.
PloS one 2011;6(4):e18390.
2011: Paul N Ulrich; Veronica Jimenez; Miyoung Park; Vicente P Martins; James Atwood; Kristen Moles; Dalis Collins; Peter Rohloff; Rick L Tarleton; Silvia N J Moreno; Ronald C Orlando; Roberto Docampo
Identification of contractile vacuole proteins in Trypanosoma cruzi.
PloS one 2011;6(3):e18013.
2010: Vicente de Paulo Martins; Michael Okura; Danijela Maric; David M Engman; Mauricio Vieira; Roberto Docampo; Silvia N J Moreno
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes.
The Journal of biological chemistry 2010;285(40):30906-17.
2010: Vicente de Paulo Martins; Melina Galizzi; Maria Laura Salto; Roberto Docampo; Silvia N J Moreno
Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis.
Infection and immunity 2010;78(10):4206-12.
2010: Kildare Miranda; Douglas A Pace; Roxana Cintron; Juliany C F Rodrigues; Jianmin Fang; Alyssa Smith; Peter Rohloff; Elvis Coelho; Felix de Haas; Wanderley de Souza; Isabelle Coppens; L David Sibley; Silvia N J Moreno
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole.
Molecular microbiology 2010;76(6):1358-75.
2010: Roberto Docampo; Paul Ulrich; Silvia N J Moreno
Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2010;365(1541):775-84.
2009: Silvia N J Moreno; Roberto Docampo
The role of acidocalcisomes in parasitic protists.
The Journal of eukaryotic microbiology 2009;56(3):208-13.
2008: Sergio H Szajnman; Guadalupe E García Liñares; Zhu-Hong Li; Cuiying Jiang; Melina Galizzi; Esteban J Bontempi; Marcela Ferella; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Bioorganic & medicinal chemistry 2008;16(6):3283-90.
2008: Silvia N J Moreno; Zhu-Hong Li
Anti-infectives targeting the isoprenoid pathway of Toxoplasma gondii.
Expert opinion on therapeutic targets 2008;12(3):253-63.
2008: Kisaburo Nagamune; Silvia N J Moreno; Eduardo N Chini; L David Sibley
Calcium regulation and signaling in apicomplexan parasites.
Sub-cellular biochemistry 2008;47():70-81.
2008: Roberto Docampo; Silvia N J Moreno
The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites.
Current pharmaceutical design 2008;14(9):882-8.
2008: Kildare Miranda; Wanderley de Souza; Helmut Plattner; Joachim Hentschel; Urara Kawazoe; Jianmin Fang; Silvia N J Moreno
Acidocalcisomes in Apicomplexan parasites.
Experimental parasitology 2008;118(1):2-9.
2007: Kisaburo Nagamune; Silvia N J Moreno; L David Sibley
Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.
Antimicrobial agents and chemotherapy 2007;51(11):3816-23.
2007: Yan Ling; Zhu-Hong Li; Kildare Miranda; Eric Oldfield; Silvia N J Moreno
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.
The Journal of biological chemistry 2007;282(42):30804-16.
2007: Guadalupe García Liñares; Santiago Gismondi; Nicolás Osa Codesido; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation.
Bioorganic & medicinal chemistry letters 2007;17(18):5068-71.
2007: Silvia N J Moreno
Drugs Against Protozoan Parasites - a Keystone Symposium.
IDrugs : the investigational drugs journal 2007;10(4):240-2.
2006: Jill Harper; My-Hang Huynh; Isabelle Coppens; Fabiola Parussini; Silvia N J Moreno; Vernon Bruce Carruthers
A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex.
Molecular biology of the cell 2006;17(10):4551-63.
2006: Jianmin Fang; Norma Marchesini; Silvia N J Moreno
A Toxoplasma gondii phosphoinositide phospholipase C (TgPI-PLC) with high affinity for phosphatidylinositol.
The Biochemical journal 2006;394(Pt 2):417-25.
2005: Norma Marchesini; Mauricio Vieira; Shuhong Luo; Silvia N J Moreno; Roberto Docampo
A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte.
The Journal of biological chemistry 2005;280(44):36841-7.
2005: Yan Ling; Gurmukh Sahota; Sarah Odeh; Julian M W Chan; Fausto G Araujo; Silvia N J Moreno; Eric Oldfield
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
Journal of medicinal chemistry 2005;48(9):3130-40.
2005: Michael Okura; Jianmin Fang; Maria Laura Salto; Randall S Singer; Roberto Docampo; Silvia N J Moreno
A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi.
The Journal of biological chemistry 2005;280(16):16235-43.
2005: Roberto Docampo; Wanderley de Souza; Kildare Miranda; Peter Rohloff; Silvia N J Moreno
Acidocalcisomes - conserved from bacteria to man.
Nature reviews. Microbiology 2005;3(3):251-61.
2005: Shuhong Luo; Felix A Ruiz; Silvia N J Moreno
The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence.
Molecular microbiology 2005;55(4):1034-45.
2004: Dawn M Wetzel; Lea Ann Chen; Felix A Ruiz; Silvia N J Moreno; L David Sibley
Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii.
Journal of cell science 2004;117(Pt 24):5739-48.
2004: Felix A Ruiz; Shuhong Luo; Silvia N J Moreno; Roberto Docampo
Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2004;10(5):563-7.
2004: Gustavo Arrizabalaga; Felix Ruiz; Silvia N J Moreno; John C Boothroyd
Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation.
The Journal of cell biology 2004;165(5):653-62.
2004: Sergio A Uyemura; Shuhong Luo; Mauricio Vieira; Silvia N J Moreno; Roberto Docampo
Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ.
The Journal of biological chemistry 2004;279(1):385-93.
2003: Manfredo Seufferheld; Mauricio C F Vieira; Felix A Ruiz; Claudia Rodrigues; Silvia N J Moreno; Roberto Docampo
Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes.
The Journal of biological chemistry 2003;278(32):29971-8.
2003: Silvia N J Moreno; Roberto Docampo
Calcium regulation in protozoan parasites.
Current opinion in microbiology 2003;6(4):359-64.
2003: Maria Laura Salto; Laura E Bertello; Mauricio Vieira; Roberto Docampo; Silvia N J Moreno; Rosa M de Lederkremer
Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote.
Eukaryotic cell 2003;2(4):756-68.
2003: Roberto Docampo; Silvia N J Moreno
Current chemotherapy of human African trypanosomiasis.
Parasitology research 2003;90 Supp 1():S10-3.
2002: Claudia Rodrigues; Felix A Ruiz; Peter Rohloff; David A Scott; Silvia N J Moreno
Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolyzable polyphosphate.
The Journal of biological chemistry 2002;277(50):48650-6.
2002: Jennie L Lovett; Norma Marchesini; Silvia N J Moreno; L David Sibley
Toxoplasma gondii microneme secretion involves intracellular Ca(2+) release from inositol 1,4,5-triphosphate (IP(3))/ryanodine-sensitive stores.
The Journal of biological chemistry 2002;277(29):25870-6.
2002: Benjamin Moreno; Claudia Rodrigues; Brian N Bailey; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Eric Oldfield
Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible.
FEBS letters 2002;523(1-3):207-12.
2002: Vanessa Yardley; Anis A Khan; Michael B Martin; Teri Slifer; Fausto G Araujo; Silvia N J Moreno; Roberto Docampo; Simon L Croft; Eric Oldfield
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
Antimicrobial agents and chemotherapy 2002;46(3):929-31.
2002: Maria Laura Salto; Tetsuya Furuya; Silvia N J Moreno; Roberto Docampo; Rosa M de Lederkremer
The phosphatidylinositol-phospholipase C from Trypanosoma cruzi is active on inositolphosphoceramide.
Molecular and biochemical parasitology 2002;119(1):131-3.
2001: Benjamin Moreno; Brian N Bailey; Shuhong Luo; Michael B Martin; Mark S Kuhlenschmidt; Silvia N J Moreno; Roberto Docampo; Eric Oldfield
(31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth.
Biochemical and biophysical research communications 2001;284(3):632-7.
2001: Roberto Docampo; Silvia N J Moreno
Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites.
Current drug targets. Infectious disorders 2001;1(1):51-61.
2001: Roberto Docampo; Silvia N J Moreno
The acidocalcisome.
Molecular and biochemical parasitology 2001;114(2):151-9.
2001: Michael B Martin; Joshua S Grimley; Jared C Lewis; H T Heath; Brian N Bailey; Howard Kendrick; Vanessa Yardley; Aura Caldera; Renee Lira; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Simon L Croft; Eric Oldfield
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Journal of medicinal chemistry 2001;44(6):909-16.
2001: Shuhong Luo; Mauricio Vieira; J Graves; L Zhong; Silvia N J Moreno
A plasma membrane-type Ca(2+)-ATPase co-localizes with a vacuolar H(+)-pyrophosphatase to acidocalcisomes of Toxoplasma gondii.
The EMBO journal 2001;20(1-2):55-64.
2000: Claudia Rodrigues; David A Scott; Brian N Bailey; Wanderley de Souza; Marlene Benchimol; Benjamin Moreno; Julio A Urbina; Eric Oldfield; Silvia N J Moreno
Vacuolar proton pyrophosphatase activity and pyrophosphate (PPi) in Toxoplasma gondii as possible chemotherapeutic targets.
The Biochemical journal 2000;349 Pt 3():737-45.
2000: Norma Marchesini; Shuhong Luo; Claudia Rodrigues; Silvia N J Moreno; Roberto Docampo
Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites.
The Biochemical journal 2000;347 Pt 1():243-53.
2000: Sergio A Uyemura; Shuhong Luo; Silvia N J Moreno; Roberto Docampo
Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondria.
The Journal of biological chemistry 2000;275(13):9709-15.
2000: T Furuya; C Kashuba; Roberto Docampo; Silvia N J Moreno
A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.
The Journal of biological chemistry 2000;275(9):6428-38.
2000: M C Vieira; Silvia N J Moreno
Mobilization of intracellular calcium upon attachment of Toxoplasma gondii tachyzoites to human fibroblasts is required for invasion.
Molecular and biochemical parasitology 2000;106(1):157-62.
1999: Julio A Urbina; Benjamin Moreno; S Vierkotter; Eric Oldfield; gilberto payares; cristina sanoja; Brian N Bailey; W Yan; David A Scott; Silvia N J Moreno; Roberto Docampo
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs.
The Journal of biological chemistry 1999;274(47):33609-15.
1999: Roberto Docampo; Silvia N J Moreno
Acidocalcisome: A novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites.
Parasitology today (Personal ed.) 1999;15(11):443-8.
1999: Shuhong Luo; Norma Marchesini; Silvia N J Moreno; Roberto Docampo
A plant-like vacuolar H(+)-pyrophosphatase in Plasmodium falciparum.
FEBS letters 1999;460(2):217-20.
1999: Vernon Bruce Carruthers; Silvia N J Moreno; L David Sibley
Ethanol and acetaldehyde elevate intracellular [Ca2+] and stimulate microneme discharge in Toxoplasma gondii.
The Biochemical journal 1999;342 ( Pt 2)():379-86.
1998: Anibal E Vercesi; Claudia Rodrigues; Sergio A Uyemura; L Zhong; Silvia N J Moreno
Respiration and oxidative phosphorylation in the apicomplexan parasite Toxoplasma gondii.
The Journal of biological chemistry 1998;273(47):31040-7.
1998: W Yan; Silvia N J Moreno
A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.
Journal of immunological methods 1998;220(1-2):123-8.
1998: David A Scott; Wanderley de Souza; Marlene Benchimol; L Zhong; HG Lu; Silvia N J Moreno; Roberto Docampo
Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi.
The Journal of biological chemistry 1998;273(34):22151-8.
1998: Marlene Benchimol; Wanderley de Souza; N Vanderheyden; L Zhong; HG Lu; Silvia N J Moreno; Roberto Docampo
Functional expression of a vacuolar-type H+-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi.
The Biochemical journal 1998;332 ( Pt 3)():695-702.
1998: T Furuya; L Zhong; J R Meyer-Fernandes; HG Lu; Silvia N J Moreno; Roberto Docampo
Ecto-protein tyrosine phosphatase activity in Trypanosoma cruzi infective stages.
Molecular and biochemical parasitology 1998;92(2):339-48.
1998: L Zhong; HG Lu; Silvia N J Moreno; Roberto Docampo
Tyrosine phosphate hydrolysis of host proteins by Trypanosoma cruzi is linked to cell invasion.
FEMS microbiology letters 1998;161(1):15-20.
1998: HG Lu; L Zhong; Wanderley de Souza; Marlene Benchimol; Silvia N J Moreno; Roberto Docampo
Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi.
Molecular and cellular biology 1998;18(4):2309-23.
1998: Silvia N J Moreno; L Zhong; HG Lu; W D Souza; Marlene Benchimol
Vacuolar-type H+-ATPase regulates cytoplasmic pH in Toxoplasma gondii tachyzoites.
The Biochemical journal 1998;330 ( Pt 2)():853-60.
1996: Roberto Docampo; Silvia N J Moreno
The role of Ca2+ in the process of cell invasion by intracellular parasites.
Parasitology today (Personal ed.) 1996;12(2):61-5.
1996: Silvia N J Moreno
Pentamidine is an uncoupler of oxidative phosphorylation in rat liver mitochondria.
Archives of biochemistry and biophysics 1996;326(1):15-20.
1996: Silvia N J Moreno; L Zhong
Acidocalcisomes in Toxoplasma gondii tachyzoites.
The Biochemical journal 1996;313 ( Pt 2)():655-9.
1995: D A Scott; Silvia N J Moreno; Roberto Docampo
Ca2+ storage in Trypanosoma brucei: the influence of cytoplasmic pH and importance of vacuolar acidity.
The Biochemical journal 1995;310 ( Pt 3)():789-94.
1995: Roberto Docampo; D A Scott; Anibal E Vercesi; Silvia N J Moreno
Intracellular Ca2+ storage in acidocalcisomes of Trypanosoma cruzi.
The Biochemical journal 1995;310 ( Pt 3)():1005-12.
1995: M E Hoffmann; J Jang; Silvia N J Moreno; Roberto Docampo
Inhibition of protein synthesis and amino acid transport by crystal violet in Trypanosoma cruzi.
The Journal of eukaryotic microbiology 1995;42(3):293-7.
1995: Gustavo Benaim; Silvia N J Moreno; G Hutchinson; Vincenza Cervino; Tomas Hermoso; Pedro J Romero; F Ruiz; W de Souza; Roberto Docampo
Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi.
The Biochemical journal 1995;306 ( Pt 1)():299-303.
1994: Anibal E Vercesi; Silvia N J Moreno; Roberto Docampo
Ca2+/H+ exchange in acidic vacuoles of Trypanosoma brucei.
The Biochemical journal 1994;304 ( Pt 1)():227-33.
1994: Silvia N J Moreno; J Silva; Anibal E Vercesi; Roberto Docampo
Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion.
The Journal of experimental medicine 1994;180(4):1535-40.
1994: Silvia N J Moreno; E G Carnieri; Roberto Docampo
Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet.
Molecular and biochemical parasitology 1994;67(2):313-20.
1993: Gustavo Benaim; C Lopez-Estraño; Roberto Docampo; Silvia N J Moreno
A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine.
The Biochemical journal 1993;296 ( Pt 3)():759-63.
1993: E G Carnieri; Silvia N J Moreno; Roberto Docampo
Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages.
Molecular and biochemical parasitology 1993;61(1):79-86.
1993: Roberto Docampo; Silvia N J Moreno; Anibal E Vercesi
Effect of thapsigargin on calcium homeostasis in Trypanosoma cruzi trypomastigotes and epimastigotes.
Molecular and biochemical parasitology 1993;59(2):305-13.
1993: Roberto Docampo; F R Gadelha; Silvia N J Moreno; Gustavo Benaim; M E Hoffmann; Anibal E Vercesi
Disruption of Ca2+ homeostasis in Trypanosoma cruzi by crystal violet.
The Journal of eukaryotic microbiology 1993;40(3):311-6.
1993: Anibal E Vercesi; Silvia N J Moreno; C F Bernardes; AR Meinicke; E C Fernandes; Roberto Docampo
Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria.
The Journal of biological chemistry 1993;268(12):8564-8.
1992: Anibal E Vercesi; Roberto Docampo; Silvia N J Moreno
Energization-dependent Ca2+ accumulation in Trypanosoma brucei bloodstream and procyclic trypomastigotes mitochondria.
Molecular and biochemical parasitology 1992;56(2):251-7.
1992: Silvia N J Moreno; Anibal E Vercesi; O P Pignataro; Roberto Docampo
Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool.
Molecular and biochemical parasitology 1992;52(2):251-61.
1992: Silvia N J Moreno; Roberto Docampo; Anibal E Vercesi
Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release.
The Journal of biological chemistry 1992;267(9):6020-6.
1991: Silvia N J Moreno; H S Ip; George A M Cross
An mRNA-dependent in vitro translation system from Trypanosoma brucei.
Molecular and biochemical parasitology 1991;46(2):265-74.
1990: Roberto Docampo; Silvia N J Moreno
The metabolism and mode of action of gentian violet.
Drug metabolism reviews 1990;22(2-3):161-78.
1989: K Stolze; Silvia N J Moreno; Ronald P Mason
Free radical intermediates formed during the oxidation of cyanide by horseradish peroxidase/H2O2 as detected with nitroso spin traps.
Journal of inorganic biochemistry 1989;37(1):45-53.
1989: F R Gadelha; Silvia N J Moreno; Wanderley de Souza; F S Cruz; Roberto Docampo
The mitochondrion of Trypanosoma cruzi is a target of crystal violet toxicity.
Molecular and biochemical parasitology 1989;34(2):117-26.
1988: Roberto Docampo; Silvia N J Moreno; F R Gadelha; Wanderley de Souza; F S Cruz
Prevention of Chagas' disease resulting from blood transfusion by treatment of blood: toxicity and mode of action of gentian violet.
Biomedical and environmental sciences : BES 1988;1(4):406-13.
1988: Silvia N J Moreno
Metabolism and mode of action of gentian violet.
Memórias do Instituto Oswaldo Cruz 1988;83 Suppl 1():308-20.
1988: Silvia N J Moreno; F R Gadelha; Roberto Docampo
Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria.
The Journal of biological chemistry 1988;263(25):12493-9.
1988: Silvia N J Moreno; K Stolze; E G Janzen; Ronald P Mason
Oxidation of cyanide to the cyanyl radical by peroxidase/H2O2 systems as determined by spin trapping.
Archives of biochemistry and biophysics 1988;265(2):267-71.
1988: Roberto Docampo; Silvia N J Moreno; F S Cruz
Enhancement of the cytotoxicity of crystal violet against Trypanosoma cruzi in the blood by ascorbate.
Molecular and biochemical parasitology 1988;27(2-3):241-7.
1988: Silvia N J Moreno
The reductive metabolism of nifurtimox and benznidazole in Crithidia fasciculata is similar to that in Trypanosoma cruzi.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1988;91(2):321-5.
1988: Silvia N J Moreno; Roberto Docampo
Reduction of 5-nitroimidazoles, nitrofurazone, and 2,4-dinitrophenol to their free radical metabolites by Tritrichomonas foetus hydrogenosomes.
Basic life sciences 1988;49():759-64.
1988: Roberto Docampo; Silvia N J Moreno; Ronald P Mason
Generation of superoxide anion and hydrogen peroxide during redox cycling of 5-(4-nitrophenyl)-penta-2,4-dienal by mammalian microsomes and enzymes.
Chemico-biological interactions 1988;65(2):123-31.
1987: Roberto Docampo; Silvia N J Moreno; R P Mason
Free radical intermediates in the reaction of pyruvate:ferredoxin oxidoreductase in Tritrichomonas foetus hydrogenosomes.
The Journal of biological chemistry 1987;262(26):12417-20.
1987: K M Morehouse; Silvia N J Moreno; Ronald P Mason
The one-electron reduction of uroporphyrin I by rat hepatic microsomes.
Archives of biochemistry and biophysics 1987;257(2):276-84.
1986: Roberto Docampo; Silvia N J Moreno
Free radical metabolism of antiparasitic agents.
Federation proceedings 1986;45(10):2471-6.
1986: Silvia N J Moreno; J Schreiber; R P Mason
Nitrobenzyl radical metabolites from microsomal reduction of nitrobenzyl chlorides.
The Journal of biological chemistry 1986;261(17):7811-5.
1986: Silvia N J Moreno; Roberto Docampo
Reduction of the metallochromic indicators murexide and tetramethylmurexide to their free radical metabolites by cytoplasmic enzymes and reducing agents.
Chemico-biological interactions 1986;57(1):17-25.
1985: Silvia N J Moreno; Roberto Docampo
Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis.
Environmental health perspectives 1985;64():199-208.
1985: Silvia N J Moreno; R P Mason; Roberto Docampo
Reduction of the metallochromic indicators arsenazo III and antipyrylazo III to their free radical metabolites by cytoplasmic enzymes.
FEBS letters 1985;180(2):229-33.
1984: Silvia N J Moreno; R P Mason; Roberto Docampo
Ca2+ and Mg2+-enhanced reduction of arsenazo III to its anion free radical metabolite and generation of superoxide anion by an outer mitochondrial membrane azoreductase.
The Journal of biological chemistry 1984;259(23):14609-16.
1984: Silvia N J Moreno; R P Mason; Roberto Docampo
Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes.
The Journal of biological chemistry 1984;259(13):8252-9.
1984: F S Cruz; L A Lopes; W De Souza; Silvia N J Moreno; R P Mason; Roberto Docampo
The photodynamic action of rose bengal on Trypanosoma cruzi.
Acta tropica 1984;41(2):99-108.
1984: Silvia N J Moreno; R P Mason; Roberto Docampo
Reduction of nifurtimox and nitrofurantoin to free radical metabolites by rat liver mitochondria. Evidence of an outer membrane-located nitroreductase.
The Journal of biological chemistry 1984;259(10):6298-305.
1984: Roberto Docampo; Silvia N J Moreno
Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi.
Reviews of infectious diseases 1984;6(2):223-38.
1983: Roberto Docampo; Silvia N J Moreno; R P Mason
Generation of free radical metabolites and superoxide anion by the calcium indicators arsenazo III, antipyrylazo III, and murexide in rat liver microsomes.
The Journal of biological chemistry 1983;258(24):14920-5.
1983: Roberto Docampo; Silvia N J Moreno; R P Muniz; F S Cruz; R P Mason
Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet).
Science (New York, N.Y.) 1983;220(4603):1292-5.
1983: Roberto Docampo; A M Casellas; E D Madeira; R L Cardoni; Silvia N J Moreno; R P Mason
Oxygen-derived radicals from Trypanosoma cruzi-stimulated human neutrophils.
FEBS letters 1983;155(1):25-30.
1983: Silvia N J Moreno; R P Mason; R P Muniz; F S Cruz; Roberto Docampo
Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus.
The Journal of biological chemistry 1983;258(7):4051-4.
1983: M Dubin; Silvia N J Moreno; E E Martino; Roberto Docampo; A O Stoppani
Increased biliary secretion and loss of hepatic glutathione in rat liver after nifurtimox treatment.
Biochemical pharmacology 1983;32(3):483-7.
1983: Roberto Docampo; M Dubin; E E Martino; Silvia N J Moreno; A O Stoppani
[Influence of nifurtimox on the glutathione content of the liver and bile in rats].
Medicina 1983;43(1):33-40.
1983: Silvia N J Moreno; Roberto Docampo; A O Stoppani
[Undesirable effects of benznidazole and nifurtimox].
Medicina 1983;43(3):291-5.
1982: Silvia N J Moreno; Roberto Docampo; R P Mason; W Leon; A O Stoppani
Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations.
Archives of biochemistry and biophysics 1982;218(2):585-91.
1981: Roberto Docampo; Silvia N J Moreno; A O Stoppani; W Leon; F S Cruz; Fernando Villalta; R F Muniz
Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi.
Biochemical pharmacology 1981;30(14):1947-51.
1981: Roberto Docampo; Silvia N J Moreno; J F Turrens; Alejandro M Katzin; S M Gonzalez-Cappa; A O Stoppani
Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi.
Molecular and biochemical parasitology 1981;3(3):169-80.
1981: Roberto Docampo; Silvia N J Moreno; A O Stoppani
Nitrofuran enhancement of microsomal electron transport, superoxide anion production and lipid peroxidation.
Archives of biochemistry and biophysics 1981;207(2):316-24.
1980: Silvia N J Moreno; D J Palmero; K Eiguchi de Palmero; Roberto Docampo; A O Stoppani
[Stimulation of lipid peroxidation and ultrastructural changes induced by nifurtimox in mammalian tissue].
Medicina 1980;40(5):553-9.