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Alessandro Moretta

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Roberta Castriconi; Maria Valeria Corrias; Alessandra Dondero; Franco Locatelli; Alessandro Moretta; Lorenzo Moretta; Francesca Bellora; Aurora Castellano; Cristina Bottino
Neuroblastoma-Derived TGF-β1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells.
Emanuela Marcenaro; Lorenzo Moretta; Silvia Pesce; Simona Sivori; Simona Carlomagno; Alessandro Moretta
KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2+ DCs or T-cell blasts.
Laure Farnault; Alain Fischer; Gérard Michel; Alessandro Moretta; Florence Orlanducci; Capucine Picard; Christophe Picard; Isabelle Thuret; Hervé Chambost; Geneviève de Saint Basile; Catherine Farnarier; Daniel Olive
Persistence of natural killer cells with expansion of a hypofunctional CD56-CD16+KIR+NKG2C+ subset in a patient with atypical Janus kinase 3-deficient severe combined immunodeficiency.

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All Publications

2013: Roberta Castriconi; Maria Valeria Corrias; Alessandra Dondero; Franco Locatelli; Alessandro Moretta; Lorenzo Moretta; Francesca Bellora; Aurora Castellano; Cristina Bottino
Neuroblastoma-Derived TGF-β1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):5321-8.
2013: Emanuela Marcenaro; Lorenzo Moretta; Silvia Pesce; Simona Sivori; Simona Carlomagno; Alessandro Moretta
KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2+ DCs or T-cell blasts.
Blood 2013;121(17):3396-401.
2013: Laure Farnault; Alain Fischer; Gérard Michel; Alessandro Moretta; Florence Orlanducci; Capucine Picard; Christophe Picard; Isabelle Thuret; Hervé Chambost; Geneviève de Saint Basile; Catherine Farnarier; Daniel Olive
Persistence of natural killer cells with expansion of a hypofunctional CD56-CD16+KIR+NKG2C+ subset in a patient with atypical Janus kinase 3-deficient severe combined immunodeficiency.
The Journal of allergy and clinical immunology 2013;131(4):1230-3, 1233.e1-2.
2012: Mirna Balsamo; Fabio Facchetti; Silvia Lonardi; Claudia Manzini; Maria Cristina Mingari; Alessandro Moretta; Lorenzo Moretta; Monica Parodi; Gabriella Pietra; Paola Queirolo; william vermi; Raffaella Augugliaro; Massimo Vitale
Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor.
European journal of immunology 2012;42(7):1833-42.
2012: Francesca Bellora; Claudia Cantoni; Roberta Castriconi; Andrea Doni; Alberto Mantovani; Alessandro Moretta; Lorenzo Moretta; Cristina Bottino
M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages.
European journal of immunology 2012;42(6):1618-26.
2012: Fredrik B Thorén; Mikael Alsterholm; Johan Bylund; Claudia Cantoni; Mariella Della Chiesa; Emanuela Marcenaro; Lorenzo Moretta; Jenny Ousbäck; Silvia Pesce; Carola Prato; Rebecca E Riise; Alessandro Moretta
Human NK Cells induce neutrophil apoptosis via an NKp46- and Fas-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(4):1668-74.
2012: Mariella Della Chiesa; Michela Falco; Francesco Frassoni; Franco Locatelli; Lorenzo Moretta; Marina Podestà; Alessandro Moretta
Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?
Blood 2012;119(2):399-410.
2012: Barbara Morandi; Alessandro Moretta; Lorenzo Moretta; Lorenzo Mortara; Roberto Accolla; Laura Chiossone; Maria Cristina Mingari; Guido Ferlazzo
Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response.
PloS one 2012;7(6):e39170.
2012: Emanuela Marcenaro; Alessandro Moretta; Silvia Pesce; Simona Carlomagno; Simona Sivori
NK/DC crosstalk in anti-viral response.
Advances in experimental medicine and biology 2012;946():295-308.
2011: Emanuela Marcenaro; Alessandro Moretta; Silvia Pesce; Simona Carlomagno; Mariella Della Chiesa; Simona Sivori
Role of alloreactive KIR2DS1(+) NK cells in haploidentical hematopoietic stem cell transplantation.
Journal of leukocyte biology 2011;90(4):661-7.
2011: Emanuela Marcenaro; Alessandro Moretta; Silvia Parolini; Silvia Pesce; Simona Carlomagno; Mariella Della Chiesa; Simona Sivori
NK cells and their receptors during viral infections.
Immunotherapy 2011;3(9):1075-86.
2011: Simona Sivori; Simona Carlomagno; Michela Falco; Elisa Romeo; Lorenzo Moretta; Alessandro Moretta
Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT.
Blood 2011;117(16):4284-92.
2011: Eric Vivier; David H Raulet; Alessandro Moretta; Michael A Caligiuri; Laurence Zitvogel; Lewis L Lanier; Wayne M Yokoyama; Sophie Ugolini
Innate or adaptive immunity? The example of natural killer cells.
Science (New York, N.Y.) 2011;331(6013):44-9.
2010: Francesca Bellora; Roberta Castriconi; Alessandra Dondero; G Reggiardo; Lorenzo Moretta; Alberto Mantovani; Alessandro Moretta; Cristina Bottino
The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21659-64.
2010: Simona Sivori; Michela Falco; Simona Carlomagno; Elisa Romeo; Cristiana Soldani; Armand Bensussan; Antonella Viola; Lorenzo Moretta; Alessandro Moretta
A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.
Blood 2010;116(10):1637-47.
2010: Simona Sivori; Michela Falco; Lorenzo Moretta; Alessandro Moretta
Extending killer Ig-like receptor function: from HLA class I recognition to sensors of microbial products.
Trends in immunology 2010;31(8):289-94.
2010: Mariella Della Chiesa; Michela Falco; Silvia Parolini; Francesca Bellora; Andrea Petretto; Elisa Romeo; Mirna Balsamo; Marco Gambarotti; Francesca Scordamaglia; Giovanna Tabellini; Fabio Facchetti; william vermi; Cristina Bottino; Alessandro Moretta; Massimo Vitale
GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues.
International immunology 2010;22(2):91-100.
2010: Enrico Brunetta; Manuela Fogli; STEFANIA VARCHETTA; Luisa Bozzo; Kelly L Hudspeth; Emanuela Marcenaro; Alessandro Moretta; Domenico Mavilio
Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection.
AIDS (London, England) 2010;24(1):27-34.
2009: Mirna Balsamo; Francesca Scordamaglia; Gabriella Pietra; Claudia Manzini; Claudia Cantoni; Monica Boitano; Paola Queirolo; william vermi; Fabio Facchetti; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari; Massimo Vitale
Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20847-52.
2009: Emanuela Marcenaro; Claudia Cantoni; Silvia Pesce; Carola Prato; Daniela Pende; Sophie Agaugué; Lorenzo Moretta; Alessandro Moretta
Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction.
Blood 2009;114(19):4108-16.
2009: Enrico Brunetta; Manuela Fogli; STEFANIA VARCHETTA; Luisa Bozzo; Kelly L Hudspeth; Emanuela Marcenaro; Alessandro Moretta; Domenico Mavilio
The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.
Blood 2009;114(18):3822-30.
2009: Mirna Balsamo; Renato Zambello; Antonella Teramo; Marco Pedrazzi; Bianca Sparatore; Francesca Scordamaglia; Daniela Pende; Maria Cristina Mingari; Lorenzo Moretta; Alessandro Moretta; Gianpietro Semenzato; Massimo Vitale
Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30.
Experimental hematology 2009;37(10):1167-75.
2009: Roberta Castriconi; Antonio Daga; Alessandra Dondero; Gianluigi Zona; Pietro Luigi Poliani; Alice Melotti; Fabrizio Griffero; Daniela Marubbi; Renato Spaziante; Francesca Bellora; Lorenzo Moretta; Alessandro Moretta; Giorgio Corte; Cristina Bottino
NK cells recognize and kill human glioblastoma cells with stem cell-like properties.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3530-9.
2009: Paolo Carrega; Gaetana Pezzino; Paola Queirolo; Irene Bonaccorsi; Michela Falco; Giuseppe Vita; Daniela Pende; Aldo Misefari; Alessandro Moretta; Maria Cristina Mingari; Lorenzo Moretta; Guido Ferlazzo
Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells.
PloS one 2009;4(12):e8132.
2009: Emanuela Marcenaro; Mariella Della Chiesa; Silvia Pesce; Sophie Agaugué; Alessandro Moretta
The NK/DC complot.
Advances in experimental medicine and biology 2009;633():7-16.
2009: Paola Costa; Simona Sivori; Federica Bozzano; Isabella Martini; Alessandro Moretta; Lorenzo Moretta; Andrea De Maria
IFN-alpha-mediated increase in cytolytic activity of maturing NK cell upon exposure to HSV-infected myelomonocytes.
European journal of immunology 2009;39(1):147-58.
2008: Lorenzo Moretta; F Locatelli; Alessandro Moretta
Alloreactive natural killer cells in targeting high-risk leukaemias.
Annals of the rheumatic diseases 2008;67 Suppl 3():iii39-43.
2008: Paola Vacca; Claudia Cantoni; Carola Prato; Ezio Fulcheri; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells.
International immunology 2008;20(11):1395-405.
2008: Emanuela Marcenaro; Bruna Ferranti; Michela Falco; Lorenzo Moretta; Alessandro Moretta
Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC.
International immunology 2008;20(9):1155-67.
2008: Sophie Agaugué; Emanuela Marcenaro; Bruna Ferranti; Lorenzo Moretta; Alessandro Moretta
Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells.
Blood 2008;112(5):1776-83.
2008: Alessandro Moretta; Franco Locatelli; Lorenzo Moretta
Human NK cells: from HLA class I-specific killer Ig-like receptors to the therapy of acute leukemias.
Immunological reviews 2008;224():58-69.
2008: Mariella Della Chiesa; Elisa Romeo; Michela Falco; Mirna Balsamo; Raffaella Augugliaro; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta; Massimo Vitale
Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.
European journal of immunology 2008;38(8):2284-9.
2008: Manuela Fogli; Domenico Mavilio; Enrico Brunetta; STEFANIA VARCHETTA; Khaled Ata; Gregg Roby; Colin Kovacs; dean follmann; Daniela Pende; Jeffrey Ward; Edward Barker; Emanuela Marcenaro; Alessandro Moretta; Anthony Fauci
Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals.
PLoS pathogens 2008;4(7):e1000101.
2008: Alessandro Moretta; Emanuela Marcenaro; Silvia Parolini; Guido Ferlazzo; Lorenzo Moretta
NK cells at the interface between innate and adaptive immunity.
Cell death and differentiation 2008;15(2):226-33.
2007: Simona Sivori; Michela Falco; Simona Carlomagno; Elisa Romeo; Lorenzo Moretta; Alessandro Moretta
Heterogeneity of TLR3 mRNA transcripts and responsiveness to poly (I:C) in human NK cells derived from different donors.
International immunology 2007;19(12):1341-8.
2007: Roberta Castriconi; Alessandra Dondero; Francesca Negri; Francesca Bellora; Paolo Nozza; Barbara Carnemolla; Alessandro Raso; Lorenzo Moretta; Alessandro Moretta; Cristina Bottino
Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity.
European journal of immunology 2007;37(11):3190-6.
2007: Roberta Castriconi; Alessandra Dondero; Michele Cilli; Emanuela Ognio; Annalisa Pezzolo; Barbara De Giovanni; Claudio Gambini; Vito Pistoia; Lorenzo Moretta; Alessandro Moretta; Maria Valeria Corrias
Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice.
Cancer immunology, immunotherapy : CII 2007;56(11):1733-42.
2007: Roberta Castriconi; Alessandra Dondero; Claudia Cantoni; Mariella Della Chiesa; Carola Prato; Marina Nanni; Maurilia Fiorini; Lucia Notarangelo; Silvia Parolini; Lorenzo Moretta; Luigi D Notarangelo; Alessandro Moretta; Cristina Bottino
Functional characterization of natural killer cells in type I leukocyte adhesion deficiency.
Blood 2007;109(11):4873-81.
2007: Silvia Parolini; Amerigo Santoro; Emanuela Marcenaro; Walter Luini; Luisa Massardi; Fabio Facchetti; David Communi; Marc Parmentier; Alessandra Majorana; Marina Sironi; Giovanna Tabellini; Alessandro Moretta; Silvano Sozzani
The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues.
Blood 2007;109(9):3625-32.
2007: Chiara Romagnani; Kerstin Juelke; Michela Falco; Barbara Morandi; Antonella D'Agostino; Roberta Costa; Giovanni B Ratto; Giuseppe Forte; Paolo Carrega; Gabrielle Lui; Romana Conte; Till Strowig; Alessandro Moretta; Christian Münz; Andreas Thiel; Lorenzo Moretta; Guido Ferlazzo
CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4947-55.
2007: Thierry Walzer; Mathieu Bléry; Julie Chaix; Nicolas Fuseri; Lionel Chasson; Scott H Robbins; Sébastien Jaeger; Pascale André; Laurent Gauthier; Laurent Daniel; Karine Chemin; Yannis Morel; Marc Dalod; Jean Imbert; Michel Pierres; Alessandro Moretta; François Romagné; Eric Vivier
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3384-9.
2007: Jacques Zimmer; Huguette Bausinger; Emmanuel Andrès; Lionel Donato; Daniel Hanau; François Hentges; Alessandro Moretta; Henri de la Salle
Phenotypic studies of natural killer cell subsets in human transporter associated with antigen processing deficiency.
PloS one 2007;2(10):e1033.
2007: Emanuela Marcenaro; Mariella Della Chiesa; Bruna Ferranti; Alessandro Moretta
In the thick of the fray: NK cells in inflamed tissues.
Advances in experimental medicine and biology 2007;598():12-9.
2007: Emanuela Marcenaro; Mariella Della Chiesa; Alessandra Dondero; Bruna Ferranti; Alessandro Moretta
It's only innate immunity but I like it.
Advances in experimental medicine and biology 2007;590():89-101.
2006: Paola Vacca; Gabriella Pietra; Michela Falco; Elisa Romeo; Cristina Bottino; Francesca Bellora; Federico Prefumo; Ezio Fulcheri; Pier Luigi Venturini; mauro costa; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function.
Blood 2006;108(13):4078-85.
2006: Mariella Della Chiesa; Simona Carlomagno; Guido Frumento; Mirna Balsamo; Claudia Cantoni; Romana Conte; Lorenzo Moretta; Alessandro Moretta; Massimo Vitale
The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function.
Blood 2006;108(13):4118-25.
2006: Emanuela Marcenaro; Alessandra Dondero; Alessandro Moretta
Multi-directional cross-regulation of NK cell function during innate immune responses.
Transplant immunology 2006;17(1):16-9.
2006: Mariella Della Chiesa; Chiara Romagnani; Andreas Thiel; Lorenzo Moretta; Alessandro Moretta
Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses.
Blood 2006;108(12):3851-8.
2006: Domenico Mavilio; Gabriella Lombardo; Audrey L Kinter; Manuela Fogli; Andrea la Sala; Saida Ortolano; Annahita Farschi; dean follmann; Roby Gregg; Colin Kovacs; Emanuela Marcenaro; Daniela Pende; Alessandro Moretta; Anthony Fauci
Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection.
The Journal of experimental medicine 2006;203(10):2339-50.
2006: Stefania Fontana; Silvia Parolini; William Vermi; Sarah Booth; Federico Gallo; Marta Donini; Marzia Benassi; Francesca Gentili; Daniela Ferrari; Luigi D Notarangelo; Patrizia Cavadini; Emanuela Marcenaro; Stefano Dusi; Marco A Cassatella; Fabio Facchetti; Gillian M Griffiths; Alessandro Moretta; Luigi D Notarangelo; Raffaele Badolato
Innate immunity defects in Hermansky-Pudlak type 2 syndrome.
Blood 2006;107(12):4857-64.
2006: Simona Sivori; Simona Carlomagno; Lorenzo Moretta; Alessandro Moretta
Comparison of different CpG oligodeoxynucleotide classes for their capability to stimulate human NK cells.
European journal of immunology 2006;36(4):961-7.
2006: Daniela Pende; Roberta Castriconi; Paola Romagnani; Grazia Maria Spaggiari; Stefania Marcenaro; Alessandra Dondero; Elena Lazzeri; Laura Lasagni; Stefania Martini; Paola Rivera; Andrea Capobianco; Lorenzo Moretta; Alessandro Moretta; Cristina Bottino
Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction.
Blood 2006;107(5):2030-6.
2005: Alessandro Moretta; Emanuela Marcenaro; Simona Sivori; Mariella Della Chiesa; Massimo Vitale; Lorenzo Moretta
Early liaisons between cells of the innate immune system in inflamed peripheral tissues.
Trends in immunology 2005;26(12):668-75.
2005: Emanuela Marcenaro; Bruna Ferranti; Alessandro Moretta
NK-DC interaction: on the usefulness of auto-aggression.
Autoimmunity reviews 2005;4(8):520-5.
2005: Barbara Morandi; Roberta Costa; Michela Falco; Silvia Parolini; Andrea De Maria; Giovanni B Ratto; Maria Cristina Mingari; Giovanni Melioli; Alessandro Moretta; Guido Ferlazzo
Distinctive lack of CD48 expression in subsets of human dendritic cells tunes NK cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3690-7.
2005: Cyril Fauriat; Alessandro Moretta; Daniel Olive; Régis T Costello
Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients.
Blood 2005;106(6):2186-8.
2005: Charles Stewart; Fanny Laugier-Anfossi; Frédéric Vély; Xavier Saulquin; Jenifer Riedmuller; Agnès Tisserant; Laurent Gauthier; François Romagné; Géraldine Ferracci; Fernando A. Arosa; Alessandro Moretta; Peter D Sun; Sophie Ugolini; Eric Vivier
Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13224-9.
2005: Domenico Mavilio; Janet Benjamin; Diana Kim; Gabriella Lombardo; Marybeth Daucher; Audrey L Kinter; Elizabeth Nies-Kraske; Emanuela Marcenaro; Alessandro Moretta; Anthony Fauci
Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys.
Blood 2005;106(5):1718-25.
2005: Lorenzo Moretta; Cristina Bottino; Daniela Pende; Massimo Vitale; Maria Cristina Mingari; Alessandro Moretta
Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis.
Immunology letters 2005;100(1):7-13.
2005: Chiara Romagnani; Mariella Della Chiesa; Siegfried Kohler; Beate Moewes; Andreas Radbruch; Lorenzo Moretta; Alessandro Moretta; Andreas Thiel
Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells.
European journal of immunology 2005;35(8):2452-8.
2005: Massimo Vitale; Mariella Della Chiesa; Simona Carlomagno; Daniela Pende; Maurizio Aricò; Lorenzo Moretta; Alessandro Moretta
NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor.
Blood 2005;106(2):566-71.
2005: Alessandro Moretta
The dialogue between human natural killer cells and dendritic cells.
Current opinion in immunology 2005;17(3):306-11.
2005: Roberto Biassoni; Manuela Fogli; Claudia Cantoni; Paola Costa; Romana Conte; Gerrit Koopman; Aurelio Aurelio Cafaro; Barbara Ensoli; Alessandro Moretta; Lorenzo Moretta; Andrea De Maria
Molecular and functional characterization of NKG2D, NKp80, and NKG2C triggering NK cell receptors in rhesus and cynomolgus macaques: monitoring of NK cell function during simian HIV infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5695-705.
2005: Emanuela Marcenaro; Mariella Della Chiesa; Francesca Bellora; Silvia Parolini; Romano Millo; Lorenzo Moretta; Alessandro Moretta
IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):3992-8.
2005: Mariella Della Chiesa; Simona Sivori; Roberta Castriconi; Emanuela Marcenaro; Alessandro Moretta
Pathogen-induced private conversations between natural killer and dendritic cells.
Trends in microbiology 2005;13(3):128-36.
2005: Daniela Pende; Grazia Maria Spaggiari; Stefania Marcenaro; Stefania Martini; Paola Rivera; Andrea Capobianco; Michela Falco; Edoardo Lanino; Ivana Pierri; Renato Zambello; Andrea Bacigalupo; Maria Cristina Mingari; Alessandro Moretta; Lorenzo Moretta
Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).
Blood 2005;105(5):2066-73.
2005: Domenico Mavilio; Gabriella Lombardo; Janet Benjamin; Diana Kim; dean follmann; Emanuela Marcenaro; M Angeline O'Shea; Audrey L Kinter; Colin Kovacs; Alessandro Moretta; Anthony Fauci
Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2886-91.
2005: Daniela Pende; Cristina Bottino; Roberta Castriconi; Claudia Cantoni; Stefania Marcenaro; Paola Rivera; Grazia Maria Spaggiari; Alessandra Dondero; Barbara Carnemolla; Nicolas Reymond; Maria Cristina Mingari; Marc Lopez; Lorenzo Moretta; Alessandro Moretta
PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.
Molecular immunology 2005;42(4):463-9.
2004: Roberta Castriconi; Alessandra Dondero; Maria Valeria Corrias; Edoardo Lanino; Daniela Pende; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta
Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.
Cancer research 2004;64(24):9180-4.
2004: Lorenzo Moretta; Cristina Bottino; Daniela Pende; Massimo Vitale; Maria Cristina Mingari; Alessandro Moretta
Different checkpoints in human NK-cell activation.
Trends in immunology 2004;25(12):670-6.
2004: Chittoor P Swaminathan; Neelowfar Wais; Vinay V Vyas; Carlos A Velikovsky; Alessandro Moretta; Lorenzo Moretta; Roberto Biassoni; Roy A Mariuzza; Nazzareno Dimasi
Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor.
Chembiochem : a European journal of chemical biology 2004;5(11):1571-5.
2004: Massimo Vitale; Simona Carlomagno; Michela Falco; Daniela Pende; Elisa Romeo; Paola Rivera; Mariella Della Chiesa; Domenico Mavilio; Alessandro Moretta
Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2.
International immunology 2004;16(10):1459-66.
2004: Roberta Castriconi; Alessandra Dondero; Raffaella Augugliaro; Claudia Cantoni; Barbara Carnemolla; Angela Rita Sementa; Francesca Negri; Romana Conte; Maria Valeria Corrias; Lorenzo Moretta; Alessandro Moretta; Cristina Bottino
Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12640-5.
2004: Manuela Fogli; Paola Costa; Giuseppe Murdaca; Maurizio Setti; Maria Cristina Mingari; Lorenzo Moretta; Alessandro Moretta; Andrea De Maria
Significant NK cell activation associated with decreased cytolytic function in peripheral blood of HIV-1-infected patients.
European journal of immunology 2004;34(8):2313-21.
2004: Alessandro Moretta; Cristina Bottino
Commentary: Regulated equilibrium between opposite signals: a general paradigm for T cell function?
European journal of immunology 2004;34(8):2084-8.
2004: Simona Sivori; Michela Falco; Mariella Della Chiesa; Simona Carlomagno; Massimo Vitale; Lorenzo Moretta; Alessandro Moretta
CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10116-21.
2004: Roberta Castriconi; Mariella Della Chiesa; Alessandro Moretta
Shaping of adaptive immunity by innate interactions.
Comptes rendus biologies 2004;327(6):533-7.
2004: Massimo Vitale; Mariella Della Chiesa; Simona Carlomagno; Chiara Romagnani; Andreas Thiel; Lorenzo Moretta; Alessandro Moretta
The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells.
European journal of immunology 2004;34(6):1715-22.
2004: Michela Falco; Emanuela Marcenaro; Elisa Romeo; Francesca Bellora; Daniele Marras; Frédéric Vély; Géraldine Ferracci; Lorenzo Moretta; Alessandro Moretta; Cristina Bottino
Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells.
European journal of immunology 2004;34(6):1663-72.
2004: Nicolas Reymond; Anne-Marie Imbert; Elisabeth Devilard; Stéphanie Fabre; Christian Chabannon; Luc Xerri; Catherine Farnarier; Claudia Cantoni; Cristina Bottino; Alessandro Moretta; Patrice Dubreuil; Marc Lopez
DNAM-1 and PVR regulate monocyte migration through endothelial junctions.
The Journal of experimental medicine 2004;199(10):1331-41.
2004: Pascale André; Roberta Castriconi; Marion Espéli; Nicolas Anfossi; Tiffany Juarez; Sophie Hue; Holli Conway; François Romagné; Alessandra Dondero; Marina Nanni; Sophie Caillat-Zucman; David H Raulet; Cristina Bottino; Eric Vivier; Alessandro Moretta; Pascale Paul
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors.
European journal of immunology 2004;34(4):961-71.
2004: Nazzareno Dimasi; Alessandro Moretta; Lorenzo Moretta; Roberto Biassoni; Roy A Mariuzza
Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):401-3.
2004: Guido Ferlazzo; Dolca Thomas; Shao-Lee Lin; Kiera Goodman; Barbara Morandi; William A Muller; Alessandro Moretta; Christian Münz
The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1455-62.
2003: Domenico Mavilio; Janet Benjamin; Marybeth Daucher; Gabriella Lombardo; Shyam Kottilil; Marie A Planta; Emanuela Marcenaro; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta; Anthony Fauci
Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15011-6.
2003: Marco Ponassi; Claudia Cantoni; Roberto Biassoni; Romana Conte; Andrea Spallarossa; Alessandro Moretta; Lorenzo Moretta; Martino Bolognesi; Domenico Bordo
Expression and crystallographic characterization of the extracellular domain of human natural killer cell triggering receptor NKp46.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2259-61.
2003: Simona Sivori; Claudia Cantoni; Silvia Parolini; Emanuela Marcenaro; Romana Conte; Lorenzo Moretta; Alessandro Moretta
IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors.
European journal of immunology 2003;33(12):3439-47.
2003: Emanuela Marcenaro; Raffaella Augugliaro; Michela Falco; Roberta Castriconi; Silvia Parolini; Simona Sivori; Elisa Romeo; Romano Millo; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta
CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity.
European journal of immunology 2003;33(12):3367-76.
2003: Cyril Fauriat; Emanuela Marcenaro; Simona Sivori; Jérôme Rey; Jean-Albert Gastaut; Alessandro Moretta; Daniel Olive; Régis T Costello
Natural killer cell-triggering receptors in patients with acute leukaemia.
Leukemia & lymphoma 2003;44(10):1683-9.
2003: Marco Ponassi; Claudia Cantoni; Roberto Biassoni; Romana Conte; Andrea Spallarossa; Alessandra Pesce; Alessandro Moretta; Lorenzo Moretta; Martino Bolognesi; Domenico Bordo
Structure of the human NK cell triggering receptor NKp46 ectodomain.
Biochemical and biophysical research communications 2003;309(2):317-23.
2003: Gabriella Pietra; Chiara Romagnani; Paola Mazzarino; Michela Falco; Enrico Millo; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10896-901.
2003: Andrea De Maria; Manuela Fogli; Paola Costa; Giuseppe Murdaca; Francesco Puppo; Domenico Mavilio; Alessandro Moretta; Lorenzo Moretta
The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44).
European journal of immunology 2003;33(9):2410-8.
2003: Renato Zambello; Michela Falco; Mariella Della Chiesa; Livio Trentin; Davide Carollo; Roberta Castriconi; Giovanna Cannas; Simona Carlomagno; Anna Cabrelle; Thierry Lamy; Carlo Agostini; Alessandro Moretta; Gianpietro Semenzato; Massimo Vitale
Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes.
Blood 2003;102(5):1797-805.
2003: Cristina Bottino; Roberta Castriconi; Daniela Pende; Paola Rivera; Marina Nanni; Barbara Carnemolla; Claudia Cantoni; Jessica Grassi; Stefania Marcenaro; Nicolas Reymond; Massimo Vitale; Lorenzo Moretta; Marc Lopez; Alessandro Moretta
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.
The Journal of experimental medicine 2003;198(4):557-67.
2003: Lorenzo Moretta; Maria Cristina Mingari; Cristina Bottino; Daniela Pende; Roberto Biassoni; Alessandro Moretta
Cellular and molecular basis of natural killer and natural killer-like activity.
Immunology letters 2003;88(2):89-93.
2003: Lorenzo Moretta; Guido Ferlazzo; Maria Cristina Mingari; Giovanni Melioli; Alessandro Moretta
Update on natural killer cells: cross-talk with dendritic cells and role in the cure of acute myeloid leukemias.
Cancer journal (Sudbury, Mass.) 2003;9(4):232-7.
2003: Claudia Cantoni; Marco Ponassi; Roberto Biassoni; Romana Conte; Andrea Spallarossa; Alessandro Moretta; Lorenzo Moretta; Martino Bolognesi; Domenico Bordo
The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.
Structure (London, England : 1993) 2003;11(6):725-34.
2003: Mariella Della Chiesa; Massimo Vitale; Simona Carlomagno; Guido Ferlazzo; Lorenzo Moretta; Alessandro Moretta
The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors.
European journal of immunology 2003;33(6):1657-66.
2003: Lorenzo Moretta; Guido Ferlazzo; Maria Cristina Mingari; Giovanni Melioli; Alessandro Moretta
Human natural killer cell function and their interactions with dendritic cells.
Vaccine 2003;21 Suppl 2():S38-42.
2003: Raffaella Augugliaro; Silvia Parolini; Roberta Castriconi; Emanuela Marcenaro; Claudia Cantoni; Marina Nanni; Lorenzo Moretta; Alessandro Moretta; Cristina Bottino
Selective cross-talk among natural cytotoxicity receptors in human natural killer cells.
European journal of immunology 2003;33(5):1235-41.
2003: Roberta Castriconi; Claudia Cantoni; Mariella Della Chiesa; Massimo Vitale; Emanuela Marcenaro; Romana Conte; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4120-5.
2003: Lorenzo Moretta; Chiara Romagnani; Gabriella Pietra; Alessandro Moretta; Maria Cristina Mingari
NK-CTLs, a novel HLA-E-restricted T-cell subset.
Trends in immunology 2003;24(3):136-43.
2003: Guido Ferlazzo; Barbara Morandi; Antonella D'Agostino; Raffaella Meazza; Giovanni Melioli; Alessandro Moretta; Lorenzo Moretta
The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells.
European journal of immunology 2003;33(2):306-13.
2002: Lorenzo Moretta; Roberto Biassoni; Cristina Bottino; Claudia Cantoni; Daniela Pende; Maria Cristina Mingari; Alessandro Moretta
Human NK cells and their receptors.
Microbes and infection / Institut Pasteur 2002;4(15):1539-44.
2002: Alessandro Moretta
Natural killer cells and dendritic cells: rendezvous in abused tissues.
Nature reviews. Immunology 2002;2(12):957-64.
2002: Daniela Pende; Paola Rivera; Stefania Marcenaro; Chien-Chung Chang; Roberto Biassoni; Romana Conte; Marek Kubin; David Cosman; Soldano Ferrone; Lorenzo Moretta; Alessandro Moretta
Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity.
Cancer research 2002;62(21):6178-86.
2002: Claudia Cantoni; Marco Ponassi; Roberto Biassoni; Romana Conte; Andrea Spallarossa; Alessandro Moretta; Lorenzo Moretta; Martino Bolognesi; Domenico Bordo
Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1843-5.
2002: Chiara Romagnani; Gabriella Pietra; Michela Falco; Enrico Millo; Paola Mazzarino; Roberto Biassoni; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11328-33.
2002: Régis T Costello; Simona Sivori; Emanuela Marcenaro; Marina Lafage-Pochitaloff; Marie-Joëlle Mozziconacci; Denis Reviron; Jean-Albert Gastaut; Daniela Pende; Daniel Olive; Alessandro Moretta
Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia.
Blood 2002;99(10):3661-7.
2002: Régis T Costello; Simona Sivori; Françoise Mallet; Danielle Sainty; Christine Arnoulet; Denis Reviron; Jean-Albert Gastaut; Alessandro Moretta; Daniel Olive
A novel mechanism of antitumor response involving the expansion of CD3+/CD56+ large granular lymphocytes triggered by a tumor-expressed activating ligand.
Leukemia 2002;16(5):855-60.
2002: Lorenzo Moretta; Cristina Bottino; Daniela Pende; Maria Cristina Mingari; Roberto Biassoni; Alessandro Moretta
Human natural killer cells: their origin, receptors and function.
European journal of immunology 2002;32(5):1205-11.
2002: Simona Sivori; Michela Falco; Emanuela Marcenaro; Silvia Parolini; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4526-31.
2002: Massimo Vitale; Jacques Zimmer; Roberta Castriconi; Daniel Hanau; Lionel Donato; Cristina Bottino; Lorenzo Moretta; Henri de la Salle; Alessandro Moretta
Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells.
Blood 2002;99(5):1723-9.
2002: Roberto Biassoni; Cristina Bottino; Claudia Cantoni; Alessandro Moretta
Human natural killer receptors and their ligands.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002;Chapter 14():Unit 14.10.
2002: Alessandro Moretta; Cristina Bottino; Maria Cristina Mingari; Roberto Biassoni; Lorenzo Moretta
What is a natural killer cell?
Nature immunology 2002;3(1):6-8.
2001: Alessandro Moretta; Cristina Bottino; Silvia Parolini; Lorenzo Moretta; Roberto Biassoni; Luigi D Notarangelo
Cellular and molecular pathogenesis of X-linked lymphoproliferative disease.
Current opinion in allergy and clinical immunology 2001;1(6):513-7.
2001: Andrea De Maria; Roberto Biassoni; Manuela Fogli; M Rizzi; Claudia Cantoni; Paola Costa; Romana Conte; Domenico Mavilio; Barbara Ensoli; Aurelio Aurelio Cafaro; Alessandro Moretta; Lorenzo Moretta
Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis NK cells.
European journal of immunology 2001;31(12):3546-56.
2001: Alessandro Moretta; Cristina Bottino; Simona Sivori; Emanuela Marcenaro; Roberta Castriconi; Mariella Della Chiesa; Simona Carlomagno; Raffaella Augugliaro; Marina Nanni; Massimo Vitale; Romano Millo
Natural killer lymphocytes: "null cells" no more.
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 2001;106(4):335-42.
2001: Cristina Bottino; Michela Falco; Silvia Parolini; Emanuela Marcenaro; Raffaella Augugliaro; Simona Sivori; E Landi; Roberto Biassoni; Luigi D Notarangelo; Lorenzo Moretta; Alessandro Moretta
NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease.
The Journal of experimental medicine 2001;194(3):235-46.
2001: Roberto Biassoni; Claudia Cantoni; Daniela Pende; Simona Sivori; Silvia Parolini; Massimo Vitale; Cristina Bottino; Alessandro Moretta
Human natural killer cell receptors and co-receptors.
Immunological reviews 2001;181():203-14.
2001: Daniela Pende; Claudia Cantoni; Paola Rivera; Massimo Vitale; Roberta Castriconi; Stefania Marcenaro; Marina Nanni; Roberto Biassoni; Cristina Bottino; Alessandro Moretta; Lorenzo Moretta
Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin.
European journal of immunology 2001;31(4):1076-86.
2001: F Vely; Marie-Alix Peyrat; Chrystelle Couedel; JF Morcet; Franck Halary; François Davodeau; F Romagne; Emmanuel Scotet; Xavier Saulquin; Elisabeth Houssaint; N Schleinitz; Alessandro Moretta; Eric Vivier; Marc Bonneville
Regulation of inhibitory and activating killer-cell Ig-like receptor expression occurs in T cells after termination of TCR rearrangements.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2487-94.
2001: Cristina Bottino; Silvia Parolini; Roberto Biassoni; Michela Falco; Luigi D Notarangelo; Alessandro Moretta
X-linked lymphoproliferative disease: the dark side of 2b4 function.
Advances in experimental medicine and biology 2001;495():63-7.
2001: Massimo Vitale; Michela Falco; Roberta Castriconi; Silvia Parolini; Renato Zambello; G Semenzato; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Identification of NKp80, a novel triggering molecule expressed by human NK cells.
European journal of immunology 2001;31(1):233-42.
2001: Alessandro Moretta; Cristina Bottino; Massimo Vitale; D Pende; C Cantoni; M C Mingari; Roberto Biassoni; Lorenzo Moretta
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
Annual review of immunology 2001;19():197-223.
2000: Roberto Biassoni; Claudia Cantoni; Michela Falco; Daniela Pende; Romano Millo; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta
Human natural killer cell activating receptors.
Molecular immunology 2000;37(17):1015-24.
2000: Cristina Bottino; Raffaella Augugliaro; Roberta Castriconi; Marina Nanni; Roberto Biassoni; Lorenzo Moretta; Alessandro Moretta
Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells.
European journal of immunology 2000;30(12):3718-22.
2000: Cristina Bottino; Michela Falco; Simona Sivori; Lorenzo Moretta; Alessandro Moretta; Roberto Biassoni
Identification and molecular characterization of a natural mutant of the p50.2/KIR2DS2 activating NK receptor that fails to mediate NK cell triggering.
European journal of immunology 2000;30(12):3569-74.
2000: Simona Sivori; Silvia Parolini; Emanuela Marcenaro; Romano Millo; Cristina Bottino; Alessandro Moretta
Triggering receptors involved in natural killer cell-mediated cytotoxicity against choriocarcinoma cell lines.
Human immunology 2000;61(11):1055-8.
2000: Lorenzo Moretta; Roberto Biassoni; Cristina Bottino; Maria Cristina Mingari; Alessandro Moretta
Human NK-cell receptors.
Immunology today 2000;21(9):420-2.
2000: Silvia Parolini; Cristina Bottino; Michela Falco; Raffaella Augugliaro; Silvia Giliani; R Franceschini; H D Ochs; H Wolf; J Y Bonnefoy; Roberto Biassoni; Lorenzo Moretta; Luigi D Notarangelo; Alessandro Moretta
X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells.
The Journal of experimental medicine 2000;192(3):337-46.
2000: Simona Sivori; Silvia Parolini; Emanuela Marcenaro; Roberta Castriconi; Daniela Pende; Romano Millo; Alessandro Moretta
Involvement of natural cytotoxicity receptors in human natural killer cell-mediated lysis of neuroblastoma and glioblastoma cell lines.
Journal of neuroimmunology 2000;107(2):220-5.
2000: Alessandro Moretta; Roberto Biassoni; Cristina Bottino; Maria Cristina Mingari; Lorenzo Moretta
Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis.
Immunology today 2000;21(5):228-34.
2000: Simona Sivori; Silvia Parolini; Michela Falco; Emanuela Marcenaro; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
2B4 functions as a co-receptor in human NK cell activation.
European journal of immunology 2000;30(3):787-93.
2000: Cristina Bottino; Roberto Biassoni; Romano Millo; Lorenzo Moretta; Alessandro Moretta
The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering.
Human immunology 2000;61(1):1-6.
1999: Chiara Vitale; Chiara Romagnani; Michela Falco; M Ponte; Massimo Vitale; Alessandro Moretta; Andrea Bacigalupo; Lorenzo Moretta; Maria Cristina Mingari
Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15091-6.
1999: Daniela Pende; Silvia Parolini; A Pessino; Simona Sivori; Raffaella Augugliaro; L Morelli; Emanuela Marcenaro; L Accame; A Malaspina; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.
The Journal of experimental medicine 1999;190(10):1505-16.
1999: Claudia Cantoni; Cristina Bottino; Raffaella Augugliaro; L Morelli; Emanuela Marcenaro; Roberta Castriconi; Massimo Vitale; Daniela Pende; Simona Sivori; Romano Millo; Roberto Biassoni; Lorenzo Moretta; Alessandro Moretta
Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.
European journal of immunology 1999;29(10):3148-59.
1999: Michela Falco; Roberto Biassoni; Cristina Bottino; Massimo Vitale; Simona Sivori; Raffaella Augugliaro; Lorenzo Moretta; Alessandro Moretta
Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.
The Journal of experimental medicine 1999;190(6):793-802.
1999: Claudia Cantoni; Michela Falco; A Pessino; Alessandro Moretta; Lorenzo Moretta; Roberto Biassoni
P49, a putative HLA-G1 specific inhibitory NK receptor belonging to the immunoglobulin Superfamily.
Journal of reproductive immunology 1999;43(2):157-65.
1999: Michela Falco; Claudia Cantoni; Cristina Bottino; Alessandro Moretta; Roberto Biassoni
Identification of the rat homologue of the human NKp46 triggering receptor.
Immunology letters 1999;68(2-3):411-4.
1999: M Ponte; Claudia Cantoni; Roberto Biassoni; Andrea Tradori Cappai; G Bentivoglio; Chiara Vitale; S Bertone; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5674-9.
1999: Simona Sivori; Daniela Pende; Cristina Bottino; Emanuela Marcenaro; A Pessino; Roberto Biassoni; Lorenzo Moretta; Alessandro Moretta
NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells.
European journal of immunology 1999;29(5):1656-66.
1999: Jacques Zimmer; Lionel Donato; Daniel Hanau; Jean-Pierre Cazenave; Alessandro Moretta; MM Tongio; Henri de la Salle
Inefficient protection of human TAP-deficient fibroblasts from autologous NK cell-mediated lysis by cytokines inducing HLA class I expression.
European journal of immunology 1999;29(4):1286-91.
1999: Roberto Biassoni; A Pessino; Cristina Bottino; Daniela Pende; Lorenzo Moretta; Alessandro Moretta
The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity.
European journal of immunology 1999;29(3):1014-20.
1999: Claudia Cantoni; Cristina Bottino; Massimo Vitale; A Pessino; Raffaella Augugliaro; A Malaspina; Silvia Parolini; Lorenzo Moretta; Alessandro Moretta; Roberto Biassoni
NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily.
The Journal of experimental medicine 1999;189(5):787-96.
1999: Roberto Biassoni; Cristina Bottino; Romano Millo; Lorenzo Moretta; Alessandro Moretta
Natural killer cell-mediated recognition of human trophoblast.
Seminars in cancer biology 1999;9(1):13-8.
1999: Alessandro Moretta; Cristina Bottino; Romano Millo; Roberto Biassoni
HLA-specific and non-HLA-specific human NK receptors.
Current topics in microbiology and immunology 1999;244():69-84.
1999: Massimo Vitale; Roberta Castriconi; Silvia Parolini; Daniela Pende; Mei-Ling Hsu; Lorenzo Moretta; David Cosman; Alessandro Moretta
The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LIR-1 + NK cell clones.
International immunology 1999;11(1):29-35.
1998: A Pessino; Simona Sivori; Cristina Bottino; A Malaspina; L Morelli; Lorenzo Moretta; Roberto Biassoni; Alessandro Moretta
Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity.
The Journal of experimental medicine 1998;188(5):953-60.
1998: Daniela Pende; L Accame; L Pareti; A Mazzocchi; Alessandro Moretta; G Parmiani; Lorenzo Moretta
The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of different HLA class I alleles.
European journal of immunology 1998;28(8):2384-94.
1998: Massimo Vitale; Cristina Bottino; Simona Sivori; L Sanseverino; Roberta Castriconi; Emanuela Marcenaro; Raffaella Augugliaro; Lorenzo Moretta; Alessandro Moretta
NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis.
The Journal of experimental medicine 1998;187(12):2065-72.
1998: Maria Cristina Mingari; Alessandro Moretta; Lorenzo Moretta
Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses.
Immunology today 1998;19(4):153-7.
1998: Maria Cristina Mingari; M Ponte; S Bertone; F Schiavetti; Chiara Vitale; R Bellomo; Alessandro Moretta; Lorenzo Moretta
HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1172-7.
1998: Jacques Zimmer; Lionel Donato; Daniel Hanau; Jean-Pierre Cazenave; MM Tongio; Alessandro Moretta; Henri de la Salle
Activity and phenotype of natural killer cells in peptide transporter (TAP)-deficient patients (type I bare lymphocyte syndrome).
The Journal of experimental medicine 1998;187(1):117-22.
1998: Alessandro Moretta; Simona Sivori; M Ponte; M C Mingari; Lorenzo Moretta
Stimulatory receptors in NK and T cells.
Current topics in microbiology and immunology 1998;230():15-23.
1998: Claudia Cantoni; Roberto Biassoni; Daniela Pende; Simona Sivori; L Accame; L Pareti; G Semenzato; Lorenzo Moretta; Alessandro Moretta; Cristina Bottino
The activating form of CD94 receptor complex: CD94 covalently associates with the Kp39 protein that represents the product of the NKG2-C gene.
European journal of immunology 1998;28(1):327-38.
1998: E Le Dréan; Frédéric Vély; L Olcese; A Cambiaggi; S Guia; G Krystal; Nadine Gervois; Alessandro Moretta; Francine Jotereau; Eric Vivier
Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.
European journal of immunology 1998;28(1):264-76.
1997: Alessandro Moretta; Silvia Parolini; Roberta Castriconi; Cristina Bottino; M Vitale; Simona Sivori; Romano Millo
Function and specificity of human natural killer cell receptors.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1997;24(6):455-68.
1997: Roberto Biassoni; A Pessino; A Malaspina; Claudia Cantoni; Cristina Bottino; Simona Sivori; Lorenzo Moretta; Alessandro Moretta
Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules.
European journal of immunology 1997;27(12):3095-9.
1997: Franck Halary; Marie-Alix Peyrat; Eric Champagne; M Lopez-Botet; Alessandro Moretta; L Moretta; Henri Vié; jean-jacques Fournie; Marc Bonneville
Control of self-reactive cytotoxic T lymphocytes expressing gamma delta T cell receptors by natural killer inhibitory receptors.
European journal of immunology 1997;27(11):2812-21.
1997: Simona Sivori; Massimo Vitale; L Morelli; L Sanseverino; Raffaella Augugliaro; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
p46, a novel natural killer cell-specific surface molecule that mediates cell activation.
The Journal of experimental medicine 1997;186(7):1129-36.
1997: Alessandro Moretta; Lorenzo Moretta
HLA class I specific inhibitory receptors.
Current opinion in immunology 1997;9(5):694-701.
1997: Frédéric Vély; S Olivero; L Olcese; Alessandro Moretta; J E Damen; L Liu; G Krystal; J C Cambier; Marc Daëron; Eric Vivier
Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs.
European journal of immunology 1997;27(8):1994-2000.
1997: Daniela Pende; Simona Sivori; L Accame; L Pareti; Michela Falco; D Geraghty; P Le Bouteiller; Lorenzo Moretta; Alessandro Moretta
HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex.
European journal of immunology 1997;27(8):1875-80.
1997: A Cambiaggi; Christophe Verthuy; Philippe Naquet; F Romagné; Pierre Ferrier; Roberto Biassoni; Alessandro Moretta; L Moretta; Eric Vivier
Natural killer cell acceptance of H-2 mismatch bone marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8088-92.
1997: Maria Cristina Mingari; Chiara Vitale; Claudia Cantoni; R Bellomo; M Ponte; F Schiavetti; S Bertone; Alessandro Moretta; Lorenzo Moretta
Interleukin-15-induced maturation of human natural killer cells from early thymic precursors: selective expression of CD94/NKG2-A as the only HLA class I-specific inhibitory receptor.
European journal of immunology 1997;27(6):1374-80.
1997: L Olcese; A Cambiaggi; G Semenzato; C Bottino; Alessandro Moretta; Eric Vivier
Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5083-6.
1997: M Bléry; Jérôme Delon; Alain Trautmann; A Cambiaggi; L Olcese; Roberto Biassoni; L Moretta; Philippe Chavrier; Alessandro Moretta; Marc Daëron; Eric Vivier
Reconstituted killer cell inhibitory receptors for major histocompatibility complex class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs.
The Journal of biological chemistry 1997;272(14):8989-96.
1997: Alessandro Moretta; Roberto Biassoni; Cristina Bottino; D Pende; Massimo Vitale; Alessandro Poggi; M C Mingari; Lorenzo Moretta
Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes.
Immunological reviews 1997;155():105-17.
1996: JJ Pérez-Villar; M Carretero; F Navarro; I Melero; A Rodríguez; C Bottino; Alessandro Moretta; Miguel López-Botet
Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5367-74.
1996: Simona Sivori; M Vitale; L Sanseverino; Silvia Parolini; M Barbaresi; Cristina Bottino; Alessandro Moretta
Inhibitory CD94 molecules identified by the Z199 monoclonal antibody recognize different HLA-class I molecules.
Transplantation proceedings 1996;28(6):3199-203.
1996: Simona Sivori; M Vitale; Cristina Bottino; Emanuela Marcenaro; L Sanseverino; Silvia Parolini; Lorenzo Moretta; Alessandro Moretta
CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies.
European journal of immunology 1996;26(10):2487-92.
1996: Cristina Bottino; Simona Sivori; M Vitale; Claudia Cantoni; Michela Falco; Daniela Pende; L Morelli; Raffaella Augugliaro; G Semenzato; Roberto Biassoni; Lorenzo Moretta; Alessandro Moretta
A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation.
European journal of immunology 1996;26(8):1816-24.
1996: Daniela Pende; Roberto Biassoni; Claudia Cantoni; S Verdiani; Michela Falco; C di Donato; L Accame; Cristina Bottino; Alessandro Moretta; Lorenzo Moretta
The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.
The Journal of experimental medicine 1996;184(2):505-18.
1996: L Olcese; P Lang; Frédéric Vély; A Cambiaggi; D Marguet; M Bléry; K L Hippen; Roberto Biassoni; Alessandro Moretta; Lorenzo Moretta; J C Cambier; Eric Vivier
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4531-4.
1996: Alessandro Poggi; Paola Costa; L Morelli; Claudia Cantoni; N Pella; F Spada; Roberto Biassoni; L Nanni; V Revello; E Tomasello; Maria Cristina Mingari; Alessandro Moretta; Lorenzo Moretta
Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity.
European journal of immunology 1996;26(6):1266-72.
1996: M Vitale; Simona Sivori; Daniela Pende; Raffaella Augugliaro; C Di Donato; A Amoroso; M Malnati; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Physical and functional independency of p70 and p58 natural killer (NK) cell receptors for HLA class I: their role in the definition of different groups of alloreactive NK cell clones.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1453-7.
1996: Roberto Biassoni; Claudia Cantoni; Michela Falco; S Verdiani; Cristina Bottino; M Vitale; R Conte; Alessandro Poggi; Alessandro Moretta; Lorenzo Moretta
The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.
The Journal of experimental medicine 1996;183(2):645-50.
1995: Alessandro Moretta; Simona Sivori; M Vitale; Daniela Pende; L Morelli; Raffaella Augugliaro; Cristina Bottino; Lorenzo Moretta
Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.
The Journal of experimental medicine 1995;182(3):875-84.
1995: JJ Pérez-Villar; I Melero; A Rodríguez; M Carretero; J Aramburu; Simona Sivori; Anna Maria Orengo; Alessandro Moretta; Miguel López-Botet
Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5779-88.
1995: Nicolai Wagtmann; Roberto Biassoni; C Cantoni; S Verdiani; M S Malnati; M Vitale; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta; Eric O Long
Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.
Immunity 1995;2(5):439-49.
1995: M Vitale; Simona Sivori; Daniela Pende; Lorenzo Moretta; Alessandro Moretta
Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3536-40.
1995: Ermanno Ciccone; Daniela Pende; L Nanni; C Di Donato; O Viale; A Beretta; M Vitale; Simona Sivori; Alessandro Moretta; Lorenzo Moretta
General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.
International immunology 1995;7(3):393-400.
1995: M S Malnati; M Peruzzi; K C Parker; W E Biddison; E Ciccone; Alessandro Moretta; Eric O Long
Peptide specificity in the recognition of MHC class I by natural killer cell clones.
Science (New York, N.Y.) 1995;267(5200):1016-8.
1995: Alessandro Poggi; N Pella; L Morelli; F Spada; V Revello; Simona Sivori; Raffaella Augugliaro; Lorenzo Moretta; Alessandro Moretta
p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans.
European journal of immunology 1995;25(2):369-76.
1994: Cristina Bottino; M Vitale; L Olcese; Simona Sivori; L Morelli; Raffaella Augugliaro; Ermanno Ciccone; Lorenzo Moretta; Alessandro Moretta
The human natural killer cell receptor for major histocompatibility complex class I molecules. Surface modulation of p58 molecules and their linkage to CD3 zeta chain, Fc epsilon RI gamma chain and the p56lck kinase.
European journal of immunology 1994;24(10):2527-34.
1994: Alessandro Moretta; M Vitale; Simona Sivori; Cristina Bottino; L Morelli; Raffaella Augugliaro; M Barbaresi; Daniela Pende; Ermanno Ciccone; M Lopez-Botet; Lorenzo Moretta
Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.
The Journal of experimental medicine 1994;180(2):545-55.
1994: Lorenzo Moretta; Ermanno Ciccone; Alessandro Poggi; M C Mingari; Alessandro Moretta
Ontogeny, specific functions and receptors of human natural killer cells.
Immunology letters 1994;40(2):83-8.
1994: Ermanno Ciccone; Daniela Pende; M Vitale; L Nanni; C Di Donato; Cristina Bottino; L Morelli; O Viale; A Amoroso; Alessandro Moretta
Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells.
European journal of immunology 1994;24(4):1003-6.
1994: M Vitale; Simona Sivori; L Sanseverino; M Barbaresi; L Morelli; L Olcese; R Agugliano; Cristina Bottino; Alessandro Moretta
Negative signalling via the P58/NKR for HLA.C alleles.
European journal of histochemistry : EJH 1994;38 Suppl 1():69-76.
1994: Lorenzo Moretta; Ermanno Ciccone; M C Mingari; Roberto Biassoni; Alessandro Moretta
Human natural killer cells: origin, clonality, specificity, and receptors.
Advances in immunology 1994;55():341-80.
1993: Alessandro Poggi; R Pardi; N Pella; L Morelli; Simona Sivori; M Vitale; V Revello; Alessandro Moretta; Lorenzo Moretta
CD45-mediated regulation of LFA1 function in human natural killer cells. Anti-CD45 monoclonal antibodies inhibit the calcium mobilization induced via LFA1 molecules.
European journal of immunology 1993;23(10):2454-63.
1993: M S Malnati; Paolo Lusso; E Ciccone; Alessandro Moretta; Lorenzo Moretta; Eric O Long
Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements.
The Journal of experimental medicine 1993;178(3):961-9.
1993: Alessandro Moretta; M Vitale; Cristina Bottino; Anna Maria Orengo; L Morelli; Raffaella Augugliaro; M Barbaresi; Ermanno Ciccone; Lorenzo Moretta
P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.
The Journal of experimental medicine 1993;178(2):597-604.
1993: R Galandrini; N Albi; G Tripodi; Daniela Zarcone; Adelmo Terenzi; Alessandro Moretta; Carlo E Grossi; Andrea Velardi
Antibodies to CD44 trigger effector functions of human T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4225-35.
1992: Ermanno Ciccone; Daniela Pende; O Viale; A Than; C Di Donato; Anna Maria Orengo; Roberto Biassoni; S Verdiani; A Amoroso; Alessandro Moretta
Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2).
The Journal of experimental medicine 1992;176(4):963-71.
1992: Lorenzo Moretta; Ermanno Ciccone; Daniela Pende; O Viale; C Di Donato; G Tripodi; Anna Maria Orengo; J Guardiola; Alessandro Moretta
Existence of a natural killer (NK) cell repertoire for (allo)antigen recognition: definition of five distinct NK-determined allospecificities in humans.
Pharmacological research : the official journal of the Italian Pharmacological Society 1992;26 Suppl 2():98-9.
1992: Daniela Zarcone; O Viale; G Cerruti; Claudya Tenca; Walter Malorni; Giuseppe Arancia; F Iosi; R Galandrini; Andrea Velardi; Alessandro Moretta
Antibodies to adhesion molecules inhibit the lytic function of MHC-unrestricted cytotoxic cells by preventing their activation.
Cellular immunology 1992;143(2):389-404.
1992: Ermanno Ciccone; Daniela Pende; O Viale; C Di Donato; G Tripodi; Anna Maria Orengo; J Guardiola; Alessandro Moretta; Lorenzo Moretta
Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans.
The Journal of experimental medicine 1992;175(3):709-18.
1992: Ermanno Ciccone; Alessandro Moretta; Lorenzo Moretta
Specific functions of human NK cells.
Immunology letters 1992;31(2):99-103.
1992: Lorenzo Moretta; Ermanno Ciccone; Daniela Pende; G Tripodi; Cristina Bottino; Alessandro Moretta
Human natural killer cells: clonally distributed specific functions and triggering surface molecules.
Laboratory investigation; a journal of technical methods and pathology 1992;66(2):138-42.
1992: Alessandro Moretta; Cristina Bottino; G Tripodi; M Vitale; Daniela Pende; L Morelli; Raffaella Augugliaro; M Barbaresi; Ermanno Ciccone; Romano Millo
Novel surface molecules involved in human NK cell activation and triggering of the lytic machinery.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1992;7():6-10.
1992: Carlo E Grossi; Ermanno Ciccone; J Zeromski; Alessandro Moretta; Lorenzo Moretta
Functional and morphologic characterization of human T lymphocytes expressing the TCR gamma/delta.
Biotherapy (Dordrecht, Netherlands) 1992;5(1):1-9.
1991: Alessandro Moretta; Alessandro Poggi; Daniela Pende; G Tripodi; Anna Maria Orengo; N Pella; Raffaella Augugliaro; Cristina Bottino; Ermanno Ciccone; Lorenzo Moretta
CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta.
The Journal of experimental medicine 1991;174(6):1393-8.
1991: Maria Cristina Mingari; Alessandro Poggi; Roberto Biassoni; R Bellomo; Ermanno Ciccone; N Pella; L Morelli; S Verdiani; Alessandro Moretta; Lorenzo Moretta
In vitro proliferation and cloning of CD3- CD16+ cells from human thymocyte precursors.
The Journal of experimental medicine 1991;174(1):21-6.
1991: Marta Fagioli; Alessandra Carè; E Ciccone; Lorenzo Moretta; Alessandro Moretta; ettore meccia; Ugo Testa; Brunangelo Falini; Francesco Grignani; Cesare Peschle
Molecular heterogeneity of the 1.0-kb T beta transcript in natural killer and gamma/delta lymphocytes.
European journal of immunology 1991;21(6):1529-34.
1991: Lorenzo Moretta; Ermanno Ciccone; Silvano Ferrini; P G Pelicci; Maria Cristina Mingari; J Zeromski; Cristina Bottino; Carlo E Grossi; Alessandro Moretta
Molecular and cellular analysis of human T lymphocytes expressing gamma delta T-cell receptor.
Immunological reviews 1991;120():117-35.
1991: Giuseppe Arancia; Walter Malorni; F Iosi; Daniela Zarcone; G Cerruti; A Favre; J Zeromski; Carlo E Grossi; Alessandro Moretta
Morphological features of cloned lymphocytes expressing gamma/delta T cell receptors.
European journal of immunology 1991;21(1):173-8.
1991: Giuseppe Arancia; Walter Malorni; F Iosi; Daniela Zarcone; G Cerruti; Alessandro Moretta; Carlo E Grossi
Growth features of T-cell receptor gamma/delta-positive cell clones.
Immunologic research 1991;10(3-4):331-3.
1991: Ermanno Ciccone; O Viale; Daniela Pende; M Malnati; Alessandro Moretta; Lorenzo Moretta
Specificity of human T lymphocytes expressing a gamma/delta T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a gamma/delta+ clone.
Current topics in microbiology and immunology 1991;173():223-7.
1990: Alessandro Moretta; Cristina Bottino; Daniela Pende; G Tripodi; G Tambussi; O Viale; Anna Maria Orengo; M Barbaresi; A Merli; Ermanno Ciccone
Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.
The Journal of experimental medicine 1990;172(6):1589-98.
1990: Ermanno Ciccone; Marco COLONna; O Viale; Daniela Pende; C Di Donato; D Reinharz; A Amoroso; M Jeannet; J Guardiola; Alessandro Moretta
Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9794-7.
1990: Alessandro Moretta; Cristina Bottino; Daniela Pende; G Tripodi; Anna Maria Orengo; Romano Millo; P G Pelicci; Ermanno Ciccone; Lorenzo Moretta
Human T lymphocytes expressing TCR gamma/delta.
Research in immunology 1990;141(7):630-5.
1990: Marta Fagioli; E Ciccone; C Bottino; Brunangelo Falini; Francesco Grignani; Alessandro Moretta; Lorenzo Moretta; Pier Giuseppe Pelicci
The C gamma 1-encoded disulphide-linked and the C gamma 2-encoded nondisulphide-linked forms of the gamma/delta heterodimer use different gamma and delta variable regions.
Blood 1990;76(2):279-84.
1990: Ermanno Ciccone; Daniela Pende; O Viale; G Tambussi; Silvano Ferrini; Roberto Biassoni; A Longo; J Guardiola; Alessandro Moretta; Lorenzo Moretta
Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells.
The Journal of experimental medicine 1990;172(1):47-52.
1990: Alessandra Carè; Pier Giuseppe Pelicci; ettore meccia; Marta Fagioli; Ugo Testa; E Ciccone; Alessandro Moretta; Lorenzo Moretta; Cesare Peschle
Natural killer cells carry the germ-line configuration of the T cell receptor delta chain gene and heterogeneously express six distinct delta transcripts.
European journal of immunology 1990;20(4):939-42.
1990: Alessandro Moretta; G Tambussi; Cristina Bottino; G Tripodi; A Merli; Ermanno Ciccone; G Pantaleo; Lorenzo Moretta
A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function.
The Journal of experimental medicine 1990;171(3):695-714.
1990: Ermanno Ciccone; Carlo E Grossi; W Malorni; G Arancia; Maria Cristina Mingari; Silvano Ferrini; Alessandro Moretta; Lorenzo Moretta
Human lymphocytes expressing a TCR gamma/delta.
Annali dell'Istituto superiore di sanità 1990;26(3-4):349-56.
1990: Marta Fagioli; Alessandra Carè; E Ciccone; Lorenzo Moretta; Alessandro Moretta; Ugo Testa; Brunangelo Falini; Francesco Grignani; Cesare Peschle; Pier Giuseppe Pelicci
Molecular studies on LAK cells.
Annali dell'Istituto superiore di sanità 1990;26(3-4):357-68.
1989: Alessandro Moretta; G Tambussi; Ermanno Ciccone; Daniela Pende; G Melioli; Lorenzo Moretta
CD16 surface molecules regulate the cytolytic function of CD3CD16+ human natural killer cells.
International journal of cancer. Journal international du cancer 1989;44(4):727-30.
1989: Alessandro Moretta; Ermanno Ciccone; G Pantaleo; G Tambussi; Cristina Bottino; G Melioli; M C Mingari; L Moretta
Surface molecules involved in the activation and regulation of T or natural killer lymphocytes in humans.
Immunological reviews 1989;111():145-75.
1989: Walter Malorni; Giuseppe Arancia; F Iosi; Gianfranco Donelli; Daniela Zarcone; Alessandro Moretta; Carlo E Grossi
A scanning electron microscopy analysis of human cytotoxic cell subsets and of their mode of conjugation with tumor cell targets.
Scanning microscopy 1989;3(3):919-26; discussion 926-7.
1989: Lorenzo Moretta; Ermanno Ciccone; Maria Cristina Mingari; J Zeromski; Cristina Bottino; Silvano Ferrini; G Tambussi; Giovanni Melioli; Carlo E Grossi; Alessandro Moretta
Phenotypic and functional characterization of human T lymphocytes expressing a gamma/delta T cell antigen receptor.
Clinical and experimental rheumatology 1989;7 Suppl 3():S9-14.
1989: Silvano Ferrini; I Prigione; Serafina Mammoliti; MI Colnaghi; S Ménard; Alessandro Moretta; Lorenzo Moretta
Re-targeting of human lymphocytes expressing the T-cell receptor gamma/delta to ovarian carcinoma cells by the use of bispecific monoclonal antibodies.
International journal of cancer. Journal international du cancer 1989;44(2):245-50.
1989: Ermanno Ciccone; O Viale; Daniela Pende; M Malnati; G Battista Ferrara; S Barocci; Alessandro Moretta; Lorenzo Moretta
Specificity of human T lymphocytes expressing a gamma/delta T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a gamma/delta clone.
European journal of immunology 1989;19(7):1267-71.
1989: Silvano Ferrini; Daniela Zarcone; Maurizio Viale; G Cerruti; R Millo; Alessandro Moretta; Carlo E Grossi
Morphologic and functional characterization of human peripheral blood T cells expressing the T cell receptor gamma/delta.
European journal of immunology 1989;19(7):1183-8.
1989: Silvano Ferrini; I Prigione; Cristina Bottino; Ermanno Ciccone; G Tambussi; Serafina Mammoliti; Lorenzo Moretta; Alessandro Moretta
Monoclonal antibodies which react with the T cell receptor gamma/delta recognize different subsets of CD3+WT31- T lymphocytes.
European journal of immunology 1989;19(1):57-61.
1989: Giovanni Melioli; Ermanno Ciccone; Maria Cristina Mingari; Daniela Pende; O Viale; G Tambussi; A Merli; Alessandro Moretta; Lorenzo Moretta
Specific recognition by CD3- NK cells: a limiting dilution analysis of the frequency of alloreactive CD3- lymphocyte precursors.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():56-7.
1989: Silvano Ferrini; I Prigione; Serafina Mammoliti; MI Colnaghi; S Menard; Alessandro Moretta; Lorenzo Moretta
Retargeting of T-cell-receptor gamma/delta+ lymphocytes against tumor cells by bispecific monoclonal antibodies. Induction of cytolytic activity and lymphokine production.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():53-5.
1989: Maria Cristina Mingari; G Tambussi; Cristina Bottino; P Varese; Alessandro Moretta
Partial inefficiency of T cell receptors gamma/delta composed of a heavy (55-kD) gamma chain to mediate cell activation upon binding to specific monoclonal antibodies.
La Ricerca in clinica e in laboratorio 1989;19(1):39-44.
1989: Lorenzo Moretta; Ermanno Ciccone; Maria Cristina Mingari; Cristina Bottino; Silvano Ferrini; G Tambussi; Giovanni Melioli; Carlo E Grossi; Alessandro Moretta
Human T lymphocytes expressing gamma/delta T cell antigen receptor.
Clinical immunology and immunopathology 1989;50(1 Pt 2):S117-23.
1989: Alessandro Moretta; Ermanno Ciccone; G Tambussi; Cristina Bottino; O Viale; Daniela Pende; A Santoni; Maria Cristina Mingari
Surface molecules involved in CD3-negative NK cell function. A novel molecule which regulates the activation of a subset of human NK cells.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():48-52.
1988: Alessandro Moretta; Cristina Bottino; Ermanno Ciccone; G Tambussi; Maria Cristina Mingari; Silvano Ferrini; Giulia Casorati; P Varese; O Viale; Nicola Migone
Human peripheral blood lymphocytes bearing T cell receptor gamma/delta. Expression of CD8 differentiation antigen correlates with the expression of the 55-kD, C gamma 2-encoded gamma chain.
The Journal of experimental medicine 1988;168(6):2349-54.
1988: Ermanno Ciccone; O Viale; Daniela Pende; M Malnati; Roberto Biassoni; Giovanni Melioli; Alessandro Moretta; Eric O Long; Lorenzo Moretta
Specific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture.
The Journal of experimental medicine 1988;168(6):2403-8.
1988: Maria Cristina Mingari; P Varese; Cristina Bottino; Giovanni Melioli; Alessandro Moretta; Lorenzo Moretta
Clonal analysis of CD4-CD8- human thymocytes expressing a T cell receptor gamma/delta chain. Direct evidence for the de novo expression of CD8 surface antigen and of cytolytic activity against tumor targets.
European journal of immunology 1988;18(11):1831-4.
1988: Cristina Bottino; G Tambussi; Silvano Ferrini; Ermanno Ciccone; P Varese; Maria Cristina Mingari; Lorenzo Moretta; Alessandro Moretta
Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor.
The Journal of experimental medicine 1988;168(2):491-505.
1988: G Pantaleo; M R Zocchi; Silvano Ferrini; A Poggi; G Tambussi; Cristina Bottino; L Moretta; Alessandro Moretta
Human cytolytic cell clones lacking surface expression of T cell receptor alpha/beta or gamma/delta. Evidence that surface structures other than CD3 or CD2 molecules are required for signal transduction.
The Journal of experimental medicine 1988;168(1):13-24.
1988: Ermanno Ciccone; Silvano Ferrini; Cristina Bottino; O Viale; I Prigione; G Pantaleo; G Tambussi; Alessandro Moretta; Lorenzo Moretta
A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s).
The Journal of experimental medicine 1988;168(1):1-11.
1988: Ermanno Ciccone; O Viale; Cristina Bottino; Daniela Pende; Nicola Migone; Giulia Casorati; G Tambussi; Alessandro Moretta; Lorenzo Moretta
Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture.
The Journal of experimental medicine 1988;167(4):1517-22.
1988: S Carrel; Alessandro Moretta; G Pantaleo; G Tambussi; P Isler; B Perussia; Jean-Charles Cerottini
Stimulation and proliferation of CD4+ peripheral blood T lymphocytes induced by an anti-CD4 monoclonal antibody.
European journal of immunology 1988;18(3):333-9.
1988: Roberto Biassoni; Silvano Ferrini; I Prigione; Alessandro Moretta; Eric O Long
CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1685-9.
1987: Andrea De Maria; M Malnati; Alessandro Moretta; Daniela Pende; Cristina Bottino; Giulia Casorati; F Cottafava; Giovanni Melioli; Maria Cristina Mingari; Nicola Migone
CD3+4-8-WT31-(T cell receptor gamma+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2-responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis.
European journal of immunology 1987;17(12):1815-9.
1987: G Pantaleo; Silvano Ferrini; M R Zocchi; Cristina Bottino; Roberto Biassoni; L Moretta; Alessandro Moretta
Analysis of signal transducing mechanisms in CD3+ CD4- CD8- cells expressing the putative T cell receptor gamma gene product.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(11):3580-4.
1987: Maria Cristina Mingari; Silvano Ferrini; Daniela Pende; Cristina Bottino; I Prigione; Alessandro Moretta; Lorenzo Moretta
Phenotypic and functional analysis of human CD3+ and CD3- clones with "lymphokine-activated killer" (LAK) activity. Frequent occurrence of CD3+ LAK clones which produce interleukin-2.
International journal of cancer. Journal international du cancer 1987;40(4):495-8.
1987: Lorenzo Moretta; Daniela Pende; Cristina Bottino; Nicola Migone; Ermanno Ciccone; Silvano Ferrini; Maria Cristina Mingari; Alessandro Moretta
Human CD3+4-8-WT31- T lymphocyte populations expressing the putative T cell receptor gamma-gene product. A limiting dilution and clonal analysis.
European journal of immunology 1987;17(9):1229-34.
1987: Cristina Bottino; Silvano Ferrini; Ermanno Ciccone; I Prigione; Daniela Pende; Maria Cristina Mingari; Lorenzo Moretta; Alessandro Moretta
Analysis of CD3-associated molecules in CD4- 8- human T cell clones lacking the typical alpha/beta T cell receptor.
La Ricerca in clinica e in laboratorio 1987;17(2):125-9.