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Gerardo Morfini

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Physiology

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Yaping Chu; Yinzhen He; Lori B Langhamer; Gerardo Morfini; Scott T Brady; Jeffrey H Kordower
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Silke Brunholz; Carole Deyts; Stefan Kins; Alfredo Lorenzo; Sangram Sisodia; Gerardo Morfini
Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.
Nicholas M Kanaan; Nichole E LaPointe; Ellen Leitman; Gerardo Morfini; Gustavo Pigino; Yuyu Song; Athena Andreadis; Lester I Binder; Scott T Brady
Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

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All Publications

2012: Yaping Chu; Yinzhen He; Lori B Langhamer; Gerardo Morfini; Scott T Brady; Jeffrey H Kordower
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Brain : a journal of neurology 2012;135(Pt 7):2058-73.
2012: Silke Brunholz; Carole Deyts; Stefan Kins; Alfredo Lorenzo; Sangram Sisodia; Gerardo Morfini
Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2012;217(3-4):353-64.
2012: Nicholas M Kanaan; Nichole E LaPointe; Ellen Leitman; Gerardo Morfini; Gustavo Pigino; Yuyu Song; Athena Andreadis; Lester I Binder; Scott T Brady
Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.
Neurobiology of aging 2012;33(4):826.e15-30.
2011: Kristina R Patterson; Kellen Voss; Sarah M Ward; Scott T Brady; Benjamin Combs; T Chris Gamblin; Nicholas M Kanaan; Gerardo Morfini; Lester I Binder
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Biochemistry 2011;50(47):10300-10.
2011: Eduarda Dráberová; Jiří Janáček; Peter W Baas; Matthew R Burns; Jean-Pierre de Chadarévian; Pavel Dráber; Kandan Kulandaivel; Agustin Legido; Pei S Liu; Gerardo Morfini; Sverre J Mörk; Vladimíra Sládková; Joanna Solowska; Tetyana Sulimenko; Stanislav Vinopal; Christos D Katsetos
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation.
Journal of neuropathology and experimental neurology 2011;70(9):811-26.
2011: Nicholas M Kanaan; Nichole E LaPointe; Gerardo Morfini; Kristina R Patterson; Gustavo Pigino; Yuyu Song; Athena Andreadis; Scott T Brady; Yifan Fu; Lester I Binder
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(27):9858-68.
2010: Daryl A Bosco; Gerardo Morfini; N Murat Karabacak; Yuyu Song; Francois Gros-Louis; Piera Pasinelli; Holly Goolsby; Benjamin A Fontaine; Nathan Lemay; Diane McKenna-Yasek; Matthew P Frosch; Jeffrey N Agar; Jean-Pierre Julien; Scott T Brady; Robert H Brown
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.
Nature neuroscience 2010;13(11):1396-403.
2010: Scott T Brady; Gerardo Morfini
A perspective on neuronal cell death signaling and neurodegeneration.
Molecular neurobiology 2010;42(1):25-31.
2010: Ina Han; YiMei You; Jeffrey Kordower; Scott T Brady; Gerardo Morfini
Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.
Journal of neurochemistry 2010;113(5):1073-91.
2009: Anita Szodorai; Yung-Hui Kuan; Silke Hunzelmann; Ulrike Engel; Ayuko Sakane; Takuya Sasaki; Yoshimi Takai; Joachim Kirsch; Ulrike Müller; Konrad Beyreuther; Scott T Brady; Gerardo Morfini; Stefan Kins
APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(46):14534-44.
2009: Gerardo Morfini; Matthew Burns; Lester I Binder; Nicholas M Kanaan; Nichole LaPointe; Daryl A Bosco; Robert H Brown; Hannah Brown; Ashutosh Tiwari; Lawrence Hayward; Julia Edgar; Klaus-Armin Nave; James Garberrn; Yuka Atagi; Yuyu Song; Gustavo Pigino; Scott T Brady
Axonal transport defects in neurodegenerative diseases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12776-86.
2009: Gerardo Morfini; Yi-Mei You; Sarah L Pollema; Agnieszka Kaminska; Katherine Liu; Katsuji Yoshioka; Benny Björkblom; Eleanor T Coffey; Carolina Bagnato; David Han; Chun-Fang Huang; Gary Banker; Gustavo Pigino; Scott T Brady
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.
Nature neuroscience 2009;12(7):864-71.
2009: Gustavo Pigino; Gerardo Morfini; Y Atagi; A Deshpande; Chunjiang Yu; Lisa M Jungbauer; Mary Jo Ladu; Jorge Busciglio; Scott T Brady
Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5907-12.
2009: Nichole E LaPointe; Gerardo Morfini; Gustavo Pigino; Irina N Gaisina; Alan P Kozikowski; Lester I Binder; Scott T Brady
The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.
Journal of neuroscience research 2009;87(2):440-51.
2009: Sarah Hatch Berth; Philip L Leopold; Gerardo Morfini
Virus-induced neuronal dysfunction and degeneration.
Frontiers in bioscience : a journal and virtual library 2009;14():5239-59.
2008: Scott R DeBoer; YiMei You; Anita Szodorai; Agnieszka Kaminska; Gustavo Pigino; Evelyn Nwabuisi; Bin Wang; Tatiana Estrada-Hernandez; Stefan Kins; Scott T Brady; Gerardo Morfini
Conventional kinesin holoenzymes are composed of heavy and light chain homodimers.
Biochemistry 2008;47(15):4535-43.
2008: Joanna M Solowska; Gerardo Morfini; Aditi Falnikar; B Timothy Himes; Scott T Brady; Dongyang Huang; Peter W Baas
Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(9):2147-57.
2007: Gerardo Morfini; Gustavo Pigino; Naoko Mizuno; Masahide Kikkawa; Scott T Brady
Tau binding to microtubules does not directly affect microtubule-based vesicle motility.
Journal of neuroscience research 2007;85(12):2620-30.
2007: Orly Lazarov; Gerardo Morfini; Gustavo Pigino; Archana Gadadhar; Xiangjun Chen; John Robinson; Hanson Ho; Scott T Brady; Sangram S Sisodia
Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(26):7011-20.
2007: Yafell Serulle; Gerardo Morfini; Gustavo Pigino; Jorge E Moreira; Mutsuyuki Sugimori; Scott T Brady; Rodolfo R Llinás
1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2437-41.
2007: Gerardo Morfini; Gustavo Pigino; K Opalach; Yafell Serulle; Jorge E Moreira; Mutsuyuki Sugimori; Rodolfo R Llinás; Scott T Brady
1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2442-7.
2007: Gerardo Morfini; Gustavo Pigino; Scott T Brady
Approaches to kinesin-1 phosphorylation.
Methods in molecular biology (Clifton, N.J.) 2007;392():51-69.
2006: Gerardo Morfini; Gustavo Pigino; Györgyi Szebenyi; Yimei You; Sarah Pollema; Scott T Brady
JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport.
Nature neuroscience 2006;9(7):907-16.
2005: Orly Lazarov; Gerardo Morfini; Edward B Lee; Mohamed H Farah; Anita Szodorai; Scott R DeBoer; Vassilis E Koliatsos; Stefan Kins; Virginia M-Y Lee; Philip C Wong; Donald L Price; Scott T Brady; Sangram S Sisodia
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2386-95.
2005: Gerardo Morfini; Gustavo Pigino; Scott T Brady
Polyglutamine expansion diseases: failing to deliver.
Trends in molecular medicine 2005;11(2):64-70.
2004: Gerardo Morfini; Györgyi Szebenyi; Hannah Brown; Varsha Shukla; Gustavo Pigino; Scott DeBoer; Uwe Beffert; Scott T Brady
A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons.
The EMBO journal 2004;23(11):2235-45.
2004: Uwe Beffert; Edwin J Weeber; Gerardo Morfini; Jane Ko; Scott T Brady; Li-Huei Tsai; J David Sweatt; Joachim Herz
Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(8):1897-906.
2003: Györgyi Szebenyi; Gerardo Morfini; Alyssa Babcock; Milena Gould; Kimberly Selkoe; David L Stenoien; Maureen Young; Pieter W Faber; Marcy E MacDonald; Michael J McPhaul; Scott T Brady
Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport.
Neuron 2003;40(1):41-52.
2003: Gustavo Pigino; Gerardo Morfini; Alejandra Pelsman; Mark P Mattson; Scott T Brady; Jorge Busciglio
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4499-508.
2003: Karl H Pfenninger; Lisandro Laurino; Diego Peretti; Xiaoxin Wang; Silvana Rosso; Gerardo Morfini; Alfredo Cáceres; Santiago Quiroga
Regulation of membrane expansion at the nerve growth cone.
Journal of cell science 2003;116(Pt 7):1209-17.
2002: Uwe Beffert; Gerardo Morfini; Hans H Bock; Huichuan Reyna; Scott T Brady; Joachim Herz
Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta.
The Journal of biological chemistry 2002;277(51):49958-64.
2002: Matthew J Donelan; Gerardo Morfini; Richard Julyan; Scott Sommers; Lori B Hays; Hiroshi Kajio; Isabelle Briaud; Richard Easom; Jeffery D Molkentin; Scott T Brady; Christopher J Rhodes
Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
The Journal of biological chemistry 2002;277(27):24232-42.
2002: Györgyi Szebenyi; Gerardo Morfini; Scott T Brady
Pictures in cell biology. GSK-3 and regulation of kinesin function.
Trends in cell biology 2002;12(5):245.
2002: Gerardo Morfini; Györgyi Szebenyi; Ravi elluru; Nancy Ratner; Scott T Brady
Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility.
The EMBO journal 2002;21(3):281-93.
2002: Gerardo Morfini; Gustavo Pigino; Uwe Beffert; Jorge Busciglio; Scott T Brady
Fast axonal transport misregulation and Alzheimer's disease.
Neuromolecular medicine 2002;2(2):89-99.
2001: Gerardo Morfini; Györgyi Szebenyi; B Richards; Scott T Brady
Regulation of kinesin: implications for neuronal development.
Developmental neuroscience 2001;23(4-5):364-76.
2001: Gerardo Morfini; M Y Tsai; Györgyi Szebenyi; Scott T Brady
Approaches to study interactions between kinesin motors and membranes.
Methods in molecular biology (Clifton, N.J.) 2001;164():147-62.
2000: M Y Tsai; Gerardo Morfini; Györgyi Szebenyi; Scott T Brady
Release of kinesin from vesicles by hsc70 and regulation of fast axonal transport.
Molecular biology of the cell 2000;11(6):2161-73.
1998: Gabriela Paglini; Gustavo Pigino; P Kunda; Gerardo Morfini; Ricardo B Maccioni; Santiago Quiroga; Adriana Ferreira; Alfredo Cáceres
Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9858-69.
1997: Gerardo Morfini; Santiago Quiroga; A Rosa; Kenneth S Kosik; Alfredo Cáceres
Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension.
The Journal of cell biology 1997;138(3):657-69.
1994: Gerardo Morfini; M C DiTella; F Feiguin; N Carri; Alfredo Cáceres
Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons.
Journal of neuroscience research 1994;39(2):219-32.
1994: M DiTella; F Feiguin; Gerardo Morfini; Alfredo Cáceres
Microfilament-associated growth cone component depends upon Tau for its intracellular localization.
Cell motility and the cytoskeleton 1994;29(2):117-30.